pons

Summary

Summary: The part of the central nervous system lying between the medulla oblongata and the mesencephalon, ventral to the cerebellum, and consisting of a pars dorsalis and a pars ventralis.

Top Publications

  1. pmc Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms
    J C Smith
    Cellular and Systems Neurobiology Section, Porter Neuroscience Research Center, NINDS, NIH, Bethesda, MD 20892, USA
    J Neurophysiol 98:3370-87. 2007
  2. ncbi Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons
    J E Lim
    Department of Pharmacology, The Ohio State University, Columbus, OH 43210, USA
    Mol Psychiatry 12:491-501. 2007
  3. ncbi Single cell activity patterns of pedunculopontine tegmentum neurons across the sleep-wake cycle in the freely moving rats
    Subimal Datta
    Sleep Research Laboratory, Program in Behavioral Neuroscience and Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci Res 70:611-21. 2002
  4. ncbi Afferent projections of the superior olivary complex
    A M Thompson
    Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Microsc Res Tech 51:330-54. 2000
  5. ncbi Modeling the ponto-medullary respiratory network
    I A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Respir Physiol Neurobiol 143:307-19. 2004
  6. ncbi GABA(A) receptor activation in the lateral parabrachial nucleus induces water and hypertonic NaCl intake
    J C Callera
    Department of Basic Science, School of Dentistry, Paulista State University, UNESP, Aracatuba, SP, Brazil
    Neuroscience 134:725-35. 2005
  7. pmc Retrograde viral vector-mediated inhibition of pontospinal noradrenergic neurons causes hyperalgesia in rats
    Patrick W Howorth
    Department of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 29:12855-64. 2009
  8. pmc Medial auditory thalamic input to the lateral pontine nuclei is necessary for auditory eyeblink conditioning
    Hunter E Halverson
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Neurobiol Learn Mem 93:92-8. 2010
  9. ncbi Fulminant hepatic failure in rats induces oxidative stress differentially in cerebral cortex, cerebellum and pons medulla
    K V Sathyasaikumar
    Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, Andhra Pradesh, India
    Neurochem Res 32:517-24. 2007
  10. ncbi Changes in tactile stimuli-induced behavior and c-Fos expression in the superficial dorsal horn and in parabrachial nuclei after sciatic nerve crush
    H Bester
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Comp Neurol 428:45-61. 2000

Research Grants

Detail Information

Publications319 found, 100 shown here

  1. pmc Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms
    J C Smith
    Cellular and Systems Neurobiology Section, Porter Neuroscience Research Center, NINDS, NIH, Bethesda, MD 20892, USA
    J Neurophysiol 98:3370-87. 2007
    ..Expression of the three-phase rhythm required the presence of the pons, generation of the two-phase rhythm depended on the integrity of Bötzinger and pre-Bötzinger complexes and ..
  2. ncbi Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons
    J E Lim
    Department of Pharmacology, The Ohio State University, Columbus, OH 43210, USA
    Mol Psychiatry 12:491-501. 2007
    ..polymorphisms within the TPH2 gene locus, we measured allele-specific expression of TPH2 mRNA in sections of human pons containing the dorsal and median raphe nuclei...
  3. ncbi Single cell activity patterns of pedunculopontine tegmentum neurons across the sleep-wake cycle in the freely moving rats
    Subimal Datta
    Sleep Research Laboratory, Program in Behavioral Neuroscience and Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci Res 70:611-21. 2002
    ..Additionally, these neurons may be an integral part of the brainstem wakefulness and REM sleep-generating mechanisms in the rat...
  4. ncbi Afferent projections of the superior olivary complex
    A M Thompson
    Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Microsc Res Tech 51:330-54. 2000
    ....
  5. ncbi Modeling the ponto-medullary respiratory network
    I A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Respir Physiol Neurobiol 143:307-19. 2004
    ..performed in the lower brainstem and involve neuronal interactions within the medulla and between the medulla and pons. A computational model of the ponto-medullary respiratory network has been developed by incorporating existing ..
  6. ncbi GABA(A) receptor activation in the lateral parabrachial nucleus induces water and hypertonic NaCl intake
    J C Callera
    Department of Basic Science, School of Dentistry, Paulista State University, UNESP, Aracatuba, SP, Brazil
    Neuroscience 134:725-35. 2005
    ..Therefore the activation of GABA(A) receptors in the lateral parabrachial nucleus induces strong NaCl intake, a small ingestion of water and pressor responses, without changes on food intake...
  7. pmc Retrograde viral vector-mediated inhibition of pontospinal noradrenergic neurons causes hyperalgesia in rats
    Patrick W Howorth
    Department of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 29:12855-64. 2009
    ....
  8. pmc Medial auditory thalamic input to the lateral pontine nuclei is necessary for auditory eyeblink conditioning
    Hunter E Halverson
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Neurobiol Learn Mem 93:92-8. 2010
    ..The results provide evidence that the auditory CS pathway necessary for delay eyeblink conditioning includes the MATN-LPN projection and the visual CS pathway includes the MPN...
  9. ncbi Fulminant hepatic failure in rats induces oxidative stress differentially in cerebral cortex, cerebellum and pons medulla
    K V Sathyasaikumar
    Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, Andhra Pradesh, India
    Neurochem Res 32:517-24. 2007
    ..study was aimed to assess the oxidative stress in different regions of brain-cerebral cortex, cerebellum and pons medulla during acute HE...
  10. ncbi Changes in tactile stimuli-induced behavior and c-Fos expression in the superficial dorsal horn and in parabrachial nuclei after sciatic nerve crush
    H Bester
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Comp Neurol 428:45-61. 2000
    ....
  11. ncbi Sodium intake by hyperosmotic rats treated with a GABA(A) receptor agonist into the lateral parabrachial nucleus
    Everton Heidi Kimura
    Department of Basic Science, School of Dentistry, Sao Paulo State University, UNESP, Rua José Bonifácio 1193, 16015 050, Aracatuba, SP, Brazil
    Brain Res 1190:86-93. 2008
    ..3 M NaCl by hyperosmotic cell-dehydrated rats, suggesting that plasma levels of renin or osmolarity do not affect sodium intake after the blockade of LPBN inhibitory mechanisms with muscimol...
  12. ncbi Role in the inspiratory off-switch of vagal inputs to rostral pontine inspiratory-modulated neurons
    Morton I Cohen
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Respir Physiol Neurobiol 143:127-40. 2004
    ..Thus the pontine and the V influences on the IOS can operate in a complementary manner dependent on state...
  13. ncbi Volumetric analysis of the pons, cerebellum and hippocampi in patients with Alzheimer's disease
    Jana Mrzílková
    Institute of Anatomy, Third Faculty of Medicine, Charles University, Prague, Czech Republic
    Dement Geriatr Cogn Disord 34:224-34. 2012
    ..in Alzheimer's disease measured via magnetic resonance imaging is accompanied by a similar volume decrease in the pons and cerebellum...
  14. pmc Temporal coding of taste in the parabrachial nucleus of the pons of the rat
    Andrew M Rosen
    Department of Psychology, Binghamton University, Binghamton, NY 13902 6000, USA
    J Neurophysiol 105:1889-96. 2011
    ..coding mechanism is also used at the next synapse in the central taste pathway, the parabrachial nucleus of the pons (PbN)...
  15. ncbi A combination of CSF tau ratio and midsaggital midbrain-to-pons atrophy for the early diagnosis of progressive supranuclear palsy
    Barbara Borroni
    The Centre for Aging Brain and Dementia, Department of Neurology, University of Brescia, Brescia, Italy
    J Alzheimers Dis 22:195-203. 2010
    Cerebrospinal fluid (CSF) tau ratio decrease (33kDa/55kDa forms) and mid-saggital midbrain-to-pons (MP) atrophy have been suggested as diagnostic markers for progressive supranuclear palsy (PSP)...
  16. ncbi Brain serotonin blockade and paradoxical salt intake in rats
    L A De Luca
    Departamento Fisiologia e Patologia, Faculdade de Odontologia, Universidade Estadual Paulista, Rua Humaita 1680, 14801 903 Araraquara, Sao Paulo, Brazil
    Neuroscience 121:1055-61. 2003
    ..The ingestion of hypertonic NaCl by rats with serotonergic blockade in the LPBN suggests that the circuits subserving sodium appetite are activated, but at the same time strongly inhibited through the LPBN, during cell dehydration...
  17. ncbi Aromatic L-amino acid decarboxylase-immunoreactive structures in human midbrain, pons, and medulla
    Kunio Kitahama
    Laboratoire de Physiologie Integrative, Cellulaire et Moléculaire, UMR5123 Centre National de la Recherche Scientifique, Bât Raphaël Dubois, Campus La Doua, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
    J Chem Neuroanat 38:130-40. 2009
    ..L-DOPA) to dopamine (DA) and 5-hydroxytryptophan (5-HTP) to serotonin (5-hydroxytryptamine: 5-HT) in the midbrain, pons, and medulla oblongata of the adult human brain...
  18. pmc Reticulospinal neurons in the pontomedullary reticular formation of the monkey (Macaca fascicularis)
    S T Sakai
    Department of Psychology and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Neuroscience 163:1158-70. 2009
    ..The present results define the origins of the reticulospinal system in the monkey and provide an important foundation for future investigations of the anatomy and physiology of this system in primates...
  19. ncbi Functional circuits mediating sensorimotor integration: quantitative comparisons of projections from rodent barrel cortex to primary motor cortex, neostriatum, superior colliculus, and the pons
    Zachary S Hoffer
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, 17033 2255, USA
    J Comp Neurol 488:82-100. 2005
    ..extent of the labeled projections to the primary motor (MI) cortex, neostriatum, superior colliculus, and basal pons. Quantitative analysis revealed that these projections terminated most extensively in the neostriatum, to a lesser ..
  20. ncbi Diffuse intrinsic pontine gliomas: a systematic update on clinical trials and biology
    M H A Jansen
    Department of Pediatrics, Division of Pediatric Oncology Hematology, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Treat Rev 38:27-35. 2012
    ..Translation of this knowledge into clinical trials in combination with improved drug distribution methods may eventually lead to more effective treatment of this devastating disease...
  21. ncbi Localization of pontine PGO wave generation sites and their anatomical projections in the rat
    S Datta
    Center for Behavioral Development and Mental Retardation, Department of Psychiatry, Boston University School of Medicine, Massachusetts 02118, USA
    Synapse 30:409-23. 1998
    ..Those microinjections elicited PGO waves only when made in the dorsal part of the nucleus subcoeruleus of the pons. In six rats, the anterograde tracer biotinylated dextran amine (BDA) was microinjected into the physiologically ..
  22. pmc Effects of orexin gene transfer in the dorsolateral pons in orexin knockout mice
    Carlos Blanco-Centurion
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    Sleep 36:31-40. 2013
    ..The dorsolateral pons was chosen because it plays a critical role in regulating muscle tone and thus it is conceivable to be involved in ..
  23. ncbi Pedunculopontine tegmental stimulation evokes striatal dopamine efflux by activation of acetylcholine and glutamate receptors in the midbrain and pons of the rat
    Gina L Forster
    Department of Psychology, Macquarie University, Sydney, NSW 2109, Australia
    Eur J Neurosci 17:751-62. 2003
    ....
  24. ncbi Antioxidant responses to chronic hypoxia in the rat cerebellum and pons
    Lalini Ramanathan
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, California, USA
    J Neurochem 93:47-52. 2005
    ..and intermittent hypoxia induces antioxidant responses, an indicator of oxidative stress, in the rat cerebellum and pons. Increased glutathione reductase (GR) activity and thiobarbituric acid reactive substance (TBARS) levels were ..
  25. ncbi The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study
    Romuald Boissard
    CNRS FRE 2469, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Eur J Neurosci 16:1959-73. 2002
    ..Furthermore, they suggest that GABAergic disinhibition and glutamate excitation of these neurons might also play a crucial role in the onset of PS...
  26. ncbi Independent and convergent signals from the pontomedullary reticular formation contribute to the control of posture and movement during reaching in the cat
    Benedicte Schepens
    Unité de Physiologie et Biomécanique de la Locomotion, Département d Education Physique et de Réadaptation, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    J Neurophysiol 92:2217-38. 2004
    ..Together our results suggest the existence of neurons that signal posture and movement independently and others that encode a convergent signal that contributes to the control of both posture and movement...
  27. ncbi Monoamines and sleep: microdialysis findings in pons and amygdala
    M N Shouse
    Department of Veterans Affairs, Greater Los Angeles Health Care System, 151A3 Sepulveda, CA, USA
    Brain Res 860:181-9. 2000
    ..Concentrations of DA did not change at either collection site across the sleep-wake cycle. We conclude that release of NE and 5-HT release modulates physiologic components related to the sleep-wake cycle, but DA does not...
  28. ncbi Sodium deprivation and salt intake activate separate neuronal subpopulations in the nucleus of the solitary tract and the parabrachial complex
    Joel C Geerling
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 504:379-403. 2007
    ..These findings offer new perspectives on the roles of sensory information from the brainstem in the regulation of sodium appetite...
  29. pmc Pontine respiratory-modulated activity before and after vagotomy in decerebrate cats
    Thomas E Dick
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4941, USA
    J Physiol 586:4265-82. 2008
    The dorsolateral (DL) pons modulates the respiratory pattern...
  30. ncbi Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study
    H J Waldvogel
    Department of Anatomy with Radiology, Faculty of Medical and Health Science, University of Auckland, Auckland, New Zealand
    J Comp Neurol 518:305-28. 2010
    ..the major GABA(A)R and GlyR subunits in the human light microscopically in the rostral and caudal one-thirds of the pons, in the middle and caudal one-thirds of the medulla oblongata, and in the first cervical segment of the spinal cord...
  31. ncbi Trace of diffusion tensor differentiates the Parkinson variant of multiple system atrophy and Parkinson's disease
    Michael F H Schocke
    Department of Radiology, University of Innsbruck, Austria
    Neuroimage 21:1443-51. 2004
    ..determined in selected brain regions including the basal ganglia, gray matter, white matter, substantia nigra, and pons. MSA-P patients had significantly higher putaminal and pallidal rTrace(D) values as well as rADCs in y- and z-..
  32. ncbi Pontocerebellar hypoplasia type 6: A British case with PEHO-like features
    Julia Rankin
    Peninsula Clinical Genetics Service, Exeter, UK
    Am J Med Genet A 152:2079-84. 2010
    ..Cranial MRI at age 14 months showed generalized cerebral atrophy, thinning of the pons and gross atrophy and flattening of the cerebellar hemispheres...
  33. ncbi Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:110-4. 2009
    ..This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110-114...
  34. ncbi Apneusis follows disruption of NMDA-type glutamate receptors in vagotomized ground squirrels
    Michael B Harris
    Department of Physiology, Dartmouth Hitchcock Medical Center, Dartmouth College, Borwell Building Hinman box, 7700, One Medical Center Drive, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 134:191-207. 2003
    ..MK-801 was administered by either bilateral pressure micro-injection into a region of the rostral dorsolateral pons, containing the medial and lateral Parabrachial and Kölliker-Fuse nuclei (the Parabrachial complex, PbC), or by ..
  35. ncbi Ganglioside patterns mature at different rates in functionally related subregions of the rat pons
    Donna M Byers
    Departmentof Biological Sciences, University of Texas at El Paso, El Paso, Tex 79968, USA
    Dev Neurosci 24:478-84. 2002
    ..the locus coeruleus, dorsal raphe, laterodorsal tegmentum, pedunculopontine tegmentum and the general region of the pons containing these nuclei in young adult (3 months), adult (12 months), and aged (24 months) rats...
  36. ncbi Activation of the parabrachio-amygdaloid pathway by immune challenge or spinal nociceptive input: a quantitative study in the rat using Fos immunohistochemistry and retrograde tract tracing
    Sabine Richard
    Station de Recherches Avicoles, Institut National de la Recherche Agronomique, 37 380 Nouzilly, France
    J Comp Neurol 481:210-9. 2005
    ....
  37. ncbi Feeding-related immune responsive brain stem neurons: association with CGRP
    J Paues
    Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, , , Sweden
    Neuroreport 12:2399-403. 2001
    ..Taken together with previous hodological and behavioral studies, these data suggest that CGRPergic parabrachial neurons may mediate lipopolysaccharide-induced anorexia by means of their projection to central nucleus of the amygdala...
  38. ncbi The projections of the midbrain periaqueductal grey to the pons and medulla oblongata in rats
    F Odeh
    Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, H-4012 Hungary
    Eur J Neurosci 14:1275-86. 2001
    ..nuclei in the rat, we labelled axons that project from the ventrolateral PAG to various regions of the pons and medulla oblongata using the anterograde tracing substance, Phaseolus vulgaris leucoagglutinin...
  39. ncbi Expression of melanocortin-4 receptor by rat parabrachial neurons responsive to immune and aversive stimuli
    J Paues
    Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Neuroscience 141:287-97. 2006
    ..These observations may thus help explain how melanocortins can reduce feeding and influence conditioned taste aversion during inflammation and other disease conditions...
  40. ncbi MRI measurements of the pons and cerebellum in children born preterm; associations with the severity of periventricular leukomalacia and perinatal risk factors
    M I Argyropoulou
    Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina, Greece
    Neuroradiology 45:730-4. 2003
    Our purpose was to measure the size of the pons and cerebellum in preterm babies with periventricular leukomalacia (PVL), and to study their relationship with the severity of PVL and with perinatal risk factors...
  41. ncbi Synaptic mechanisms of inspiratory off-switching evoked by pontine pneumotaxic stimulation in cats
    Mari Okazaki
    Department of Pharmacology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Neurosci Res 44:101-10. 2002
    ..The present results suggest that pneumotaxic and vagal inputs converge on the common IOS circuit, and the effectiveness of both inputs is modulated by NMDA receptors...
  42. ncbi Can target-to-pons ratio be used as a reliable method for the analysis of [11C]PIB brain scans?
    P Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Hammersmith Hospital, Imperial College, London, UK
    Neuroimage 60:1716-23. 2012
    ..Therefore, we investigated whether the pons could be used as an alternative reference region for the analysis of [(11)C]PIB binding in AD...
  43. ncbi Brainstem neurons projecting to the rostral ventral respiratory group (VRG) in the medulla oblongata of the rat revealed by co-application of NMDA and biocytin
    Y Zheng
    Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, C N R S, Gif sur Yvette, France
    Brain Res 782:113-25. 1998
    Groups of neurons in the medulla and pons are essential for the rhythm generation, pattern formation and modulation of respiration. The rostral Ventral Respiratory Group (rVRG) is thought to be a crucial area for rhythm generation...
  44. pmc Pontine respiratory activity involved in inspiratory/expiratory phase transition
    Michael Mörschel
    Department of Neuro and Sensory Physiology, University Medicine Gottingen, Georg August University, Humboldtallee 23, 37073 Gottingen, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2517-26. 2009
    ..Thus, habituation reduces sensory feedback, so the role of the pons, and specifically the KF, for IE phase transition may increase dramatically...
  45. pmc Functional connectivity in the pontomedullary respiratory network
    Lauren S Segers
    Department of Molecular Pharmacology and Physiology, School of Biomedical Sciences, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612 4799, USA
    J Neurophysiol 100:1749-69. 2008
    ..Correlation linkage maps generated for the data support our four motivating hypotheses and suggest network mechanisms for proposed modulatory functions of the PRG...
  46. pmc The midbrain to pons ratio: a simple and specific MRI sign of progressive supranuclear palsy
    Luke A Massey
    Sara Koe PSP Research Centre, Rita Lila Weston Institute for Neurology Studies and Queen Square Brain Bank, Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK
    Neurology 80:1856-61. 2013
    ..We aimed to develop in histologically proven disease a simple measure of the midbrain and pons on sagittal MRI to identify PSP.
  47. ncbi Removal of a chopstick out of the cavernous sinus, pons, and cerebellar vermis through the superior orbital fissure
    Delphine Mitilian
    Department of Paediatric Neurosurgery, Necker Enfants Malades Hospital, 156 rue de Vaugirard, 75015 Paris, France
    Acta Neurochir (Wien) 151:1295-7. 2009
    ..The foreign body was successfully pulled out in one piece surgically...
  48. ncbi Pontine hypoplasia in 5p-syndrome: A key MRI finding for a diagnosis
    Takeshi Ninchoji
    Department of Pediatrics, Kameda Medical Center, Kamogawa shi, Chiba 296 8602, Japan
    Brain Dev 32:571-3. 2010
    ..Older patients with brainstem hypoplasia should be asked about a history of a high-pitched cry in infancy so as not to miss this syndrome...
  49. ncbi Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)
    Sean J Pittock
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Brain 133:2626-34. 2010
    ..All patients had symmetric curvilinear gadolinium enhancement peppering the pons and extending variably into the medulla, brachium pontis, cerebellum, midbrain and occasionally spinal cord...
  50. ncbi Three cases of CLIPPERS: a serial clinical, laboratory and MRI follow-up study
    O Kastrup
    Department of Neurology, University Duisburg Essen, Hufelandstr 55, 45122, Essen, Germany
    J Neurol 258:2140-6. 2011
    ..imaging (MRI) disclosed patchy spot-like gadolinium enhancement in a "salt-and-pepper like appearance" in the pons, midbrain and cerebellum, in two cases with thalamic and in the other with spinal involvement...
  51. pmc Treatment of paediatric pontine glioma with oral trophosphamide and etoposide
    J E A Wolff
    St Hedwigs Klinik, Hämato Onkologie, Steinmetzstr 1 3, 93049 Regensburg, Germany
    Br J Cancer 87:945-9. 2002
    ..pontine glioma on MRI or histologically proven anaplastic astrocytoma/glioblastoma multiforme located in the pons, were eligible...
  52. pmc Identification of cholinergic and non-cholinergic neurons in the pons expressing phosphorylated cyclic adenosine monophosphate response element-binding protein as a function of rapid eye movement sleep
    S Datta
    Laboratory of Sleep and Cognitive Neuroscience, Boston University School of Medicine, 85 East Newton Street, Suite M 902, Boston, MA 02118, USA
    Neuroscience 163:397-414. 2009
    ..Moreover the results indicate that during REM sleep, PPT intracellular PKA activation and a transcriptional cascade involving pCREB occur exclusively in the cholinergic neurons...
  53. ncbi Hypertensive brain stem encephalopathy: clinically silent massive edema of the pons
    F Morello
    Division of Neurology, Civil Hospital, Arzignano (VI, Italy
    Neurol Sci 22:317-20. 2001
    ..T2-weighted magnetic resonance images showed hyperintensity and edema of the pons without any parietooccipital lesions, but with hyperintense lesions at the level of the basal nuclei, insula and ..
  54. ncbi The rhombencephalon and breathing: a view from the pons
    Donald R McCrimmon
    Department of Physiology and Institute for Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Respir Physiol Neurobiol 143:103-4. 2004
  55. ncbi Globosa neurons: a distinct subgroup of noradrenergic neurons in the caudal pons of rats
    Paul F McCulloch
    Department of Physiology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Brain Res 964:164-7. 2003
    ..They have prominent dendritic processes that are oriented transversely and extend into the lateral lemniscus. These neurons are activated during underwater diving in rats, but at present their function is unknown...
  56. ncbi Modulation of Hering-Breuer reflex by ventrolateral pons
    Hui Wang
    Shandong University, Laboratory of Respiratory Neurobiology, Institute of Physiology, School of Medicine, Jinan 250012, PR China
    Adv Exp Med Biol 605:387-92. 2008
    ..Hering-Breuer reflex (HBR) is known to be modulated by the classic pneumotaxic center in the dorsolateral pons. In this work, we investigated whether the HBR was also modulated by the ventrolateral pons (vl-pons)...
  57. ncbi Natriorexigenic effect of baclofen is reduced by AT₁ receptor blockade in the lateral parabrachial nucleus
    Camila Zambone Cardoso Da Silva
    Department of Basic Science, School of Dentistry, UNESP, Univ Estadual Paulista, Rodovia Marechal Rondom, km 527, 16018 805, Aracatuba, Sao Paulo, Brazil
    Brain Res Bull 86:348-54. 2011
    ....
  58. ncbi Pontocerebellar hypoplasia type 1: new leads for an earlier diagnosis
    Michael S Salman
    Department of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Child Neurol 18:220-5. 2003
    ..Our cases provide clinical and previously unreported electroretinographic evidence for neurodegeneration in pontocerebellar hypoplasia type 1 and call for the expansion of the disease phenotype...
  59. pmc Saccade-related, long-lead burst neurons in the monkey rostral pons
    Chris R S Kaneko
    Department of Physiology and Biophysics, Box 357290, and Washington National Primate Research Center, University of Washington, Seattle, WA 98195 7290, USA
    J Neurophysiol 95:979-94. 2006
    ..To address this issue, I mapped and recorded LLBNs in the rostral pons to measure their discharge characteristics and correlate those characteristics with the metrics of the concurrent ..
  60. ncbi Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: advancing basic and translational research and cooperation in DIPG
    Ute Bartels
    Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada
    J Neurooncol 105:119-25. 2011
    ..The advancement of basic and translational research and cooperation was the objective of the Toronto Think Tank, as new approaches are urgently needed...
  61. ncbi Inactivation of the pons blocks medullary-induced muscle tone suppression in the decerebrate cat
    J Kohyama
    Dept. of Psychiatry, UCLA School of Medicine, Sepulveda VAMC, North Hills, Calif 91343, USA
    Sleep 21:695-9. 1998
    ..A two-way interaction between the medulla and pons is hypothesized to play a crucial role in the control of muscle tone.
  62. ncbi Autopsy case of later-onset pontocerebellar hypoplasia type 1: pontine atrophy and pyramidal tract involvement
    Masafumi Sanefuji
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Child Neurol 25:1429-34. 2010
    ..We present a child who exhibited neurological deterioration and progressive atrophy of the cerebellum and pons, with onset of symptoms at 20 months and death at 15 years of age...
  63. ncbi Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride and sucrose intake in rats
    L B de Oliveira
    Department of Physiology and Pathology, School of Dentistry, Sao Paulo State University, UNESP, Araraquara, Sao Paulo, Brazil
    Neuroscience 183:160-70. 2011
    ..The natriorexigenic effect is not secondary to alterations in blood pressure or sodium urinary excretion. In addition, baclofen injected into the LPBN also induces 0.06 M sucrose intake...
  64. ncbi Multi-segmental innervation of single pontine reticulospinal axons in the cervico-thoracic region of the cat: anterograde PHA-L tracing study
    K Matsuyama
    National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
    J Comp Neurol 377:234-50. 1997
    ..Both ipsilateral and bilateral projections terminated mainly in laminae VII or VIII although the branching patterns varied from axon to axon. Individual stem axons, in general, showed similar termination patterns at each level...
  65. ncbi Central nervous system medulloepithelioma: a series of eight cases including two arising in the pons
    P T Molloy
    Department of Pathology, The Children s Hospital of Philadelphia, Department of Pathology, The Children s Hospital of Philadelphia Pennsylvania, USA
    J Neurosurg 84:430-6. 1996
    ..Medulloepithelioma, often confused with less aggressive PNETs, can mimic intrinsic brainstem glioma, responds poorly to treatment, and is prone to CNS dissemination at the time of tumor progression...
  66. ncbi Hypotonia, weakness, and pontocerebellar hypoplasia in siblings
    Chang Yong Tsao
    Department of Pediatrics and Neurology, The Ohio State University, Nationwide Children s Hospital, Columbus, OH 43205, USA
    Semin Pediatr Neurol 15:151-3. 2008
    ..We herein briefly review familial spinal muscular atrophy with type 1 pontocerebellar hypoplasia in children...
  67. pmc Cluster headache attacks and multiple sclerosis
    Salvatore Gentile
    Neurology II Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15, I 10126, Torino, Italy
    J Headache Pain 8:245-7. 2007
    ..The association between cluster headache and MS has been rarely described before. This case suggests that in patients with cluster headache neuroimaging is often useful in order to exclude structural lesions...
  68. ncbi Lesions of the pedunculopontine tegmental nucleus reduce paradoxical sleep (PS) propensity: evidence from a short-term PS deprivation study in rats
    S Deurveilher
    Laboratoire de Neurobiologie de l'Apprentissage, , UMR CNRS 8620, , 91405 Orsay Cedex, France
    Eur J Neurosci 13:1963-76. 2001
    ..In summary, although spontaneous PS was found to be unaltered, the PS deprivation procedure used in this study demonstrated the dysfunctioning of PS caused by PPT lesions...
  69. ncbi Ultrastructural and permeability features of microvessels in the hippocampus, cerebellum and pons of senescence-accelerated mice (SAM)
    M Ueno
    Second Department of Pathology, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, 761 0793, Kagawa, Japan
    Neurobiol Aging 22:469-78. 2001
    ..peroxidase (HRP) and ultrastructural features of microvessels were examined in the hippocampus, cerebellum and pons of SAMP8 and SAMR1 (control) mice...
  70. ncbi Infantile onset progressive cerebellar atrophy and anterior horn cell degeneration--a late onset variant of PCH-1?
    Dorit Lev
    Metabolic Neurogenetic Service, Wolfson Medical Center, Holon, Affiliated to Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Paediatr Neurol 12:97-101. 2008
    ..The term pontocerebellar hypoplasia is used when there is a structural defect, originating in utero of both pons and cerebellar hemispheres...
  71. ncbi Expression of alpha-7 and alpha-4 nicotinic acetylcholine receptors by GABAergic neurons of rostral ventral medulla and caudal pons
    Ozra Dehkordi
    Department of Surgery, Howard University Hospital Washington, DC 20060, USA
    Brain Res 1185:95-102. 2007
    ..isoform (GAD67) and parvalbumin (PV) as anatomical markers to identify the GABAergic neurons of the RVM and caudal pons and performed double labeling to evaluate the expression of alpha-7 and alpha-4 nAChRs by GAD67 and PV-..
  72. ncbi [Pontocerebellar hypoplasia type I and mitochondrial pathology]
    C Gomez-Lado
    Rev Neurol 45:639-40. 2007
  73. ncbi Morphology of single pontine reticulospinal axons in the lumbar enlargement of the cat: a study using the anterograde tracer PHA-L
    K Matsuyama
    Department of Biological Control System, National Institute for Physiological Sciences, Okazaki, Japan
    J Comp Neurol 410:413-30. 1999
    ..These results suggest that the long descending pontine reticulospinal pathway is composed of different types of axons that may innervate the cervical and lumbar enlargements in continuity in a similar manner...
  74. ncbi Adaptation to hypobaric hypoxia involves GABA A receptors in the pons
    Yee Hsee Hsieh
    Department of Pharmacology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
    Am J Physiol Regul Integr Comp Physiol 294:R549-57. 2008
    ..binding sites, characteristic of GABA(A) receptors containing alpha4 and alpha6 subunits, increase in the pons. Immunohistochemistry revealed that CHH-induced GABA(A) receptor subunit expression is localized in regions of ..
  75. ncbi Ventrolateral pons mediates short-term depression of respiratory frequency after brief hypoxia
    T E Dick
    Division of Pulmonary and Critical Care Medicine, Departments of Medicine and of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4941, USA
    Respir Physiol 121:87-100. 2000
    ..We have identified a potential neural mechanism that depends on the integrity of the ventrolateral (vl) pons. Our studies show that: (a) blockade of activity in the vl pons prevents the short-term decrease in fR after ..
  76. ncbi Reduced midbrain-pons serotonin transporter binding in patients with obsessive-compulsive disorder
    S G Hasselbalch
    Neurobiology Research Unit, The Neuroscience Center, Rigshospitalet, Copenhagen, Denmark
    Acta Psychiatr Scand 115:388-94. 2007
    ..To evaluate current hypothesis regarding the pathophysiology of obsessive-compulsive disorder (OCD) by studying the serotonin receptor binding in patients with OCD using single photon emission computerized tomography (SPECT)...
  77. ncbi Retrograde degeneration of the corticospinal tract associated with pontine infarction
    Shunsuke Kobayashi
    Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Neurol Sci 236:91-3. 2005
    ..An autopsy confirmed the existence of retrograde degeneration extending from the pons to the internal capsule, evidence that retrograde degeneration in the corticospinal tract occurs above the pontine ..
  78. ncbi Age and sex differences in the cerebellum and the ventral pons: a prospective MR study of healthy adults
    N Raz
    Department of Psychology, The University of Memphis, Memphis, TN 38152-3230, USA
    AJNR Am J Neuroradiol 22:1161-7. 2001
    ..purpose of this study was to examine whether age differences in the volume of cerebellar regions and the ventral pons are differential or generalized, whether the age-related shrinkage is linear or exponential, and whether there are ..
  79. ncbi Distribution and medullary projection of respiratory neurons in the dorsolateral pons of the rat
    K Ezure
    Department of Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Neuroscience 141:1011-23. 2006
    The dorsolateral pons around the parabrachial nucleus including the Kölliker-Fuse nucleus is closely linked with the medullary respiratory center and plays an important role in respiratory control...
  80. ncbi Somatotopic location of corticospinal tract at pons in human brain: a diffusion tensor tractography study
    Ji Heon Hong
    Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, 317 1 Daemyungdong, Namku, Taegu 705 717, Republic of Korea
    Neuroimage 51:952-5. 2010
    ..tractography (DTT) study has yet investigated the somatotopic location of the corticospinal tract (CST) at the pons. In the current study, we used DTT to investigate the somatotopic location of the CST at the pons in the human ..
  81. ncbi Pontomedullary distribution of 5-HT2A receptor-like protein in the rat
    R Fay
    Center for Sleep and Respiratory Neurobiology and Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6046, USA
    J Comp Neurol 418:323-45. 2000
    ....
  82. ncbi Corpus callosum, pons, and cortical white matter in alcoholic women
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Alcohol Clin Exp Res 26:400-6. 2002
    ..To measure the effect of alcohol abuse on white matter brain macrostructure in women with alcoholism and to determine whether observed abnormalities interact with age...
  83. ncbi MR imaging of middle cerebellar peduncle width: differentiation of multiple system atrophy from Parkinson disease
    Giuseppe Nicoletti
    Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    Radiology 239:825-30. 2006
    ..To prospectively assess if middle cerebellar peduncle (MCP) atrophy, evaluated at magnetic resonance (MR) imaging, can help differentiate multiple system atrophy (MSA) from Parkinson disease (PD)...
  84. ncbi Up-regulation of the isoenzymes MAO-A and MAO-B in the human basal ganglia and pons in Huntington's disease revealed by quantitative enzyme radioautography
    Grayson Richards
    Preclinical Neuroscience Research, F Hoffmann La Roche Ltd, CH 4070 Basel, Switzerland
    Brain Res 1370:204-14. 2011
    ..50%; p<0.01) in the putamen and substantia nigra pars compacta of the basal ganglia and in the pons. Higher increases in MAO-B (75%-200%; p<0...
  85. ncbi Somatotopic organization of the corticospinal tract in the human brainstem: a MRI-based mapping analysis
    Juergen J Marx
    Department of Neurology, Johannes Gutenberg University Mainz, Mainz, Germany
    Ann Neurol 57:824-31. 2005
    ..Infarction affected the pons in 85% of cases...
  86. ncbi Neurons in the pontomedullary reticular formation signal posture and movement both as an integrated behavior and independently
    Benedicte Schepens
    Unité de Physiologie et Biomécanique de la Locomotion, Département d Education Physique et de Réadaptation, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    J Neurophysiol 100:2235-53. 2008
    ..Another population of neurons contributes to the control of postural support independently of the nature of the activity in the reaching limb...
  87. ncbi Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR
    J E Lim
    Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, 43210, USA
    Mol Psychiatry 11:649-62. 2006
    ..AEI) of SERT mRNA to assess quantitatively the contribution of SERTLPR to mRNA expression in human post-mortem pons tissue sections containing serotonergic neurons of the dorsal and median raphe nuclei...
  88. ncbi Measurement of the midbrain diameter on routine magnetic resonance imaging: a simple and accurate method of differentiating between Parkinson disease and progressive supranuclear palsy
    M Warmuth-Metz
    Department of Neuroradiology, University of Wurzburg, Germany
    Arch Neurol 58:1076-9. 2001
    Anteroposterior diameters of the suprapontine midbrain, the pons, and the collicular plate were measured in 50 patients with various parkinsonian syndromes (Parkinson disease [PD] [n = 20], progressive supranuclear palsy [PSP] [n = 16], ..
  89. ncbi Hypocretin-1 causes G protein activation and increases ACh release in rat pons
    Rene Bernard
    Departments of Pharmacology and Anaesthesiology, University of Michigan, 7433 Medical Sciences Building I, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Eur J Neurosci 18:1775-85. 2003
    ..002) increased (87%) ACh release. This finding is consistent with the interpretation that one mechanism by which hypocretin promotes arousal is by enhancing cholinergic neurotransmission in the pontine reticular formation...
  90. ncbi RNA synthesis in pons necessary for maintenance of bladder overactivity after cerebral infarction in rat
    Osamu Yokoyama
    Department of Urology, Fukui Medical University, Matsuoka, Fukui, Japan
    J Urol 169:1878-84. 2003
    ..Therefore, we examined the influence of the RNA synthesis inhibitor actinomycin D (Banyu Pharmaceutical Co., Ltd., Tokyo, Japan) on bladder overactivity induced by left middle cerebral artery occlusion...
  91. ncbi The human basis pontis: motor syndromes and topographic organization
    Jeremy D Schmahmann
    Department of Neurology VBK 915, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    Brain 127:1269-91. 2004
    Clinical-anatomic correlations were performed in 25 patients with focal infarcts in the basilar pons to determine whether pontine lacunar syndromes conform to discrete clinical entities, and whether there is topographic organization of ..
  92. pmc The effects of lesions in the dorsolateral pons on the coordination of swallowing and breathing in awake goats
    J M Bonis
    Medical College of Wisconsin, Department of Physiology, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States
    Respir Physiol Neurobiol 175:272-82. 2011
    The purpose of this retrospective study was to gain insight into the contribution of the dorsolateral pons to the coordination of swallowing and breathing in awake goats...
  93. ncbi Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammal
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Appl Physiol 100:2096-7; discussion 2097-8, 2103-8. 2006
  94. ncbi Early fatal pontocerebellar hypoplasia in premature twin sisters
    V Chaves-Vischer
    Hopital des Enfants, Hopitaux Universitaires, Geneva, Switzerland
    Eur J Paediatr Neurol 4:171-6. 2000
    ..They presented with hypertonia, jitteriness, spontaneous and provoked myoclonic jerks (hyperekplexia), apnoeic episodes, and progressive microcephaly. They died at 7 weeks of age from respiratory failure...
  95. ncbi Spectrum of malformations of the hindbrain (cerebellum, pons, and medulla) in a cohort of children with high rate of parental consanguinity
    Laszlo Sztriha
    Department of Paediatrics, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Am J Med Genet A 135:134-41. 2005
    We review 25 patients with a spectrum of hindbrain (cerebellum, pons, and medulla) malformations from a cohort of children with high parental consanguinity rate. Twenty-three of the 25 patients were born to consanguineous parents...
  96. pmc Effects of hypocretin2-saporin and antidopamine-beta-hydroxylase-saporin neurotoxic lesions of the dorsolateral pons on sleep and muscle tone
    Carlos Blanco-Centurion
    West Roxbury VA Medical Center and Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    Eur J Neurosci 19:2741-52. 2004
    ..It is not known how the hypocretin innervation of the pons regulates sleep-wake states as pontine lesions have never been shown to increase sleep...
  97. ncbi Effects of alcohol dependence comorbidity and antipsychotic medication on volumes of the thalamus and pons in schizophrenia
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Am J Psychiatry 160:1110-6. 2003
    Postmortem and in vivo brain imaging studies have identified abnormalities in the thalamus and the pons in both schizophrenia and alcoholism...
  98. pmc Hypertensive encephalopathy: isolated pons involvement mimicking central pontine myelinolysis
    S Gamanagatti
    Korean J Radiol 7:218-9. 2006
  99. ncbi Role of the dorsolateral pontine nucleus in short-term adaptation of the horizontal vestibuloocular reflex
    Seiji Ono
    Division of Visual Science, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30022, USA
    J Neurophysiol 89:2879-85. 2003
    ..Our results suggest that visual error signals for short-term adaptation of the VOR are derived from sources other than the DLPN perhaps including other basilar pontine nuclei and the accessory optic system...
  100. ncbi Effects of electrical stimulation of the posterior part of the hypothalamus on the spike activity of neurons in the oral nucleus of the pons
    O Yu Dergacheva
    A B Kogan Science Research Institute of Neurocybernetics, Rostov State University, 194 1 Stachka Prospekt, 344090, Rostov on Don, Russia
    Neurosci Behav Physiol 35:865-70. 2005
    Chronic experiments were performed on four cats to study evoked spike activity in neurons in the oral nucleus of the pons to electrical stimulation of the posterior hypothalamus in the waking, slow-wave sleep, and paradoxical sleep states...
  101. ncbi The oculomotor role of the pontine nuclei and the nucleus reticularis tegmenti pontis
    Peter Thier
    Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Prog Brain Res 151:293-320. 2006
    ..This review focuses on the two major nuclei of this group taking a precerebellar position, the pontine nuclei and the nucleus reticularis tegmenti pontis, both intimately involved in the visual guidance of eye movements...

Research Grants65

  1. Persisting Grand Mal and Myoclonic Seizures in JME including Veterans
    Antonio V Delgado-Escueta; Fiscal Year: 2013
    ..caudate, putamen, globus pallidus, thalamus substantia nigra and brainstem especially superior coliculus and dorsal pons varolii of Myoclonin1/efhc1 KO mice with myoclonias only versus Myoclonin1/efhc1 KO mice with grand mal seizures...
  2. CNS AUTONOMIC PATHWAYS: CENTRAL CARDIOVASCULAR CONTROL
    Arthur D Loewy; Fiscal Year: 2012
    ..one of the objectives is to map the efferent connections of one of its major relay sites in the dorsolateral pons called the pre-locus coeruleus nucleus...
  3. Neurobiological Mechanisms of Sympathetic Regulation in Sleep Apnea
    Anne M Fink; Fiscal Year: 2013
    ..My research is focused on the pedunculopontine tegmental nucleus (PPT), a cluster of neurons in the rostral pons. The PPT has a well-established role in controlling rapid eye movement (REM) sleep, a state associated with ..
  4. Precursor cell-niche interactions and the genesis of brainstem gliomas
    MICHELLE MONJE-DEISSEROTH; Fiscal Year: 2012
    ..The majority of these are diffusely infiltrative gliomas of the ventral pons, a devastating cancer that occurs in school age children (peak at age 7) and almost invariably results in death...
  5. The unfolded protein response and neurodegenerative tauopathies
    Lauren D Stutzbach; Fiscal Year: 2013
    ..NFTs) and glial tangles comprised of hyperphosphorylated protein tau (htau) in the brainstem, particularly in the pons and medulla...
  6. Pontine Control of REM Atonia
    Elda Arrigoni; Fiscal Year: 2013
    ..disease, and it often appears in early stages when the disease involves the lower brainstem including the pons. Considerable evidence demonstrates that neurons of the sublaterodorsal (SLD) nucleus of the pons, also known as ..
  7. Pulse Oximeter for Newborn Screening
    ROBERT A LIEBERMAN; Fiscal Year: 2013
    ..The goal of this project is to develop a pulse oximeter for newborn screening (PONS) that has many advantages: 1) simple to use thus reducing training time and cost;2) much shorter procedure time;3) ..
  8. Temporal Coding in the Gustatory System of the Brain
    Patricia M Di Lorenzo; Fiscal Year: 2013
    ..is focused on temporal coding in the nucleus of the solitary tract (NTS) and the parabrachial nucleus of the pons (PbN), respectively the first and second central relays in the rat taste system...
  9. Cytoarchitecture of Central Respiratory Afferents Processing
    Gang Song; Fiscal Year: 2013
    ..In this project, we will target specific respiratory neurons in rat pneumotaxic nuclei in the dorsolateral pons that have recently been implicated in co-mediating the Hering- Breuer reflex and hypoxic chemoreflex...
  10. Envronment-Sensitive genes in motoneuron degeneration
    Teepu Siddique; Fiscal Year: 2010
    ..b>PONs are antioxidant and detoxify pesticides, while CYP7B1 is inhibited by agricultural fungicides...
  11. Tracing neuronal lineage and understanding cell fate decisions in the pons
    Kamal Sharma; Fiscal Year: 2013
    ..Successful completion of these studies will demonstrate that embryonic V2a neurons originating from r1 are recruited to distinct neural circuits that regulate appetitive Pavlovian learning and sleep. ..
  12. Non-Invasive Quantitation of Cellular and Biochemical Changes in Hereditary Ataxi
    GULIN OZ; Fiscal Year: 2009
    ..indicators of gliosis (myo-inositol and glutamine) will be quantified by high field (4 tesla) MRS in cerebella and pons of patients with spinocerebellar ataxias SCA2 and SCA6 in comparison to healthy controls...
  13. Characterization of germinal niches in the developing human brainstem
    MATTHEW CHRISTOPHER TATE; Fiscal Year: 2010
    ..studies from our laboratory have identified proliferating populations of neural progenitors in the developing pons. However, little is known regarding the contribution of such progenitor populations to brainstem histogenesis and ..
  14. Forebrain-Cerebellar Interaction During Learning
    John F Disterhoft; Fiscal Year: 2012
    The aims of this research program are to use the whisker barrel cortex and pons as "anchor points" to examine information processing loops within the forebrain during whisker signaled trace eyeblink conditioning (EBC)...
  15. Astroglial Orexin in Sleep Disorders
    Priyattam J Shiromani; Fiscal Year: 2013
    ..GFAP promoter driven) in three specific brain regions, two of which are implicated in network sleep models (TMN, pons) and the third, striatum, will serve as control...
  16. Neural Basis of Saccade Preparation
    Neeraj J Gandhi; Fiscal Year: 2013
    ..Blinks have been shown to compromise the integrity of the saccadic inhibition network at the level of the pons, and if the blink is triggered after presentation of the saccade target (and permission to initiate the movement), ..
  17. CRCNS: State dependent neural mechanisms for respiratory pattern generation
    Ilya A Rybak; Fiscal Year: 2010
    ..We also suggest that the pons controls the state of the pre-Botzinger complex (and hence the rhythmogenic mechanism) directly and/or through ..
  18. CHANGES IN BRAIN AMINES BY DENTAL LOCAL ANESTHETICS
    ALFRED CIARLONE; Fiscal Year: 1980
    ..Brain regions to be analyzed consist of the cerebral cortex, striatum, midbrain, hypothalamus, cerebellum, and pons-medulla oblongata...
  19. Neuronal Mechanisms for Working Memory in Prefrontal Cortex
    Michael D Mauk; Fiscal Year: 2013
    ..has demonstrated that TEC requires persistent activity of an interconnected pathway from medial (m) PFC to lateral pons (and then to cerebellum) that is required for TEC...
  20. CNS MEDIATION OF CONDITIONED BRADYCARDIA
    PHILIP MC CABE; Fiscal Year: 1990
    ..ACE), which courses through the lateral hypothalamus, lateral zona incerta (LZI), and parabrachial nucleus of the pons, before terminating at the cells of origin of the vagus nerve in the medulla...
  21. ADENOSINE RECEPTORS AND THE PATHOPHYSIOLOGY OF SIDS
    H Zielke; Fiscal Year: 1990
    ..We propose that adenosine receptors located in the medulla and pons, two recognized centers of CNS respiratory control, are involved in this control, and that abnormalities in ..
  22. HYPOTHALAMUS & NARCOTIC EFFECTS
    HEMENDRA BHARGAVA; Fiscal Year: 1992
    ..delta) and 3 H-U 69593 (k) to CNS regions (spinal cord, amygdala, hippocampus, hypothalamus, corpus striatum, pons and medulla, midbrain and cerebral cortex) will be determined...
  23. Ventral Mesopontine Junction and Motor Activity
    Yuan Yang Lai; Fiscal Year: 2006
    ..We hypothesize that the ventral mesopontine junction (VMPJ), including the rostroventral pons and the caudal part of the dopaminergic retrorubral nucleus and ventral tegmental area, plays a crucial role in the ..
  24. Taste Coding by Neural Circuitry in the Brain Stem
    PATRICIA DI LORENZO; Fiscal Year: 2005
    ..recorded in NTS cells, as well as evoked responses from electrical stimulation of the parabrachial nucleus of the pons (PbN), the second synapse in the ascending gustatory pathway...
  25. GABA-A receptor plasticity: regulation by hypoxia
    RUTH SIEGEL; Fiscal Year: 2009
    ..triggers de novo ?6 subunit mRNA and protein expression and increases ?4 and ? subunit mRNA levels in the pons, a brainstem region involved in maintaining homeostasis...
  26. Intertrigeminal region control of apnea
    Miodrag Radulovacki; Fiscal Year: 2007
    ..anatomical pathway recently has been demonstrated in which the intertrigeminal region (ITR) of the lateral pons is posited as a key regulatory site for apneic reflexes...
  27. NEURAL SIGNALLING OF SALT INTAKE
    ALEX BAERTSCHI; Fiscal Year: 1993
    ..sublocus coeruleus, locus coeruleus, caudal periaqueductal gray, lateral parabrachial nuclei, medial dorsal pons, nucleus tractus solitarius, or median preoptic nucleus...
  28. Tangle Formation in P301L Transgenic Mice
    Michael Hutton; Fiscal Year: 2005
    ..cDNA generated from midbrain, pons and spinal cord regions from the P301 L tau mice will be subjected to microarray analysis to identify and profile ..
  29. HINDBRAIN AND NEUROPEPTIDE Y--CONTROL OF FOOD INTAKE
    ERIC CORP; Fiscal Year: 2002
    ..where NPY acts to stimulate feeding? Based on preliminary results, we hypothesize a locus exists in the dorsal pons central gray area...
  30. NEURAL SYSTEMS OF TASTE AND INGESTIVE BEHAVIOR
    Ralph Norgren; Fiscal Year: 1990
    ..The caudal brainstem, the medulla, pons, and midbrain, contains the first central synapses for both gustatory and vagal visceral afferent axons, the ..
  31. Parabrachial and precoeruleus glutamatergic neurons in sleep-wake homeostasis
    ELIZABETH HUR; Fiscal Year: 2009
    ..The long term objective of the proposed studies is to establish two specific nuclei in the pons as a crucial part of the brainstem reticular formation...
  32. SUPRAPONTINE CONTROL OF MICTURITION
    James Roppolo; Fiscal Year: 1990
    ..controlled from several levels of the central nervous system (CNS) including the lumbosacral spinal cord, rostral pons, hypothalamus, subcortical nuclei, and the cerebral cortex...
  33. COCAINE EFFECTS ON CNS-RELATED CARDIORESPIRATORY CONTROL
    Ronald Harper; Fiscal Year: 1990
    ..These structures include the central nucleus of the amygdala, the nucleus parabrachialis medialis of the pons, the nucleus of the solitary tract, and the hypoglossal nucleus...
  34. INFLAMMATORY NOCICEPTION EFFECT ON MEDULLARY NEURONS
    Donna Hammond; Fiscal Year: 2000
    ..in particular, about the effects of inflammatory nociception on the pain modulatory pathways that originate in the pons or medulla...
  35. INTERACTIONS OF CANNABIS AND OTHER DRUGS
    ARTHUR CHAN; Fiscal Year: 1980
    ..between these phenomena and changes in protein synthesis in vivo in the cerebral cortex, midbrain, cerebellum and pons-medulla of the rat brain...
  36. STUDY OF OCULOMOTOR CONTROL SYSTEM
    David Robinson; Fiscal Year: 1993
    ..Pursuit, saccadic and vestibular commands are distributed over the vestibulaR-oculomotor regions of the caudal pons. Action directions of second-order anal afferents are distributed over all directions as are the action directions ..
  37. Radiotherapy planning via autosegmented brain structures
    DARRYL KAURIN; Fiscal Year: 2002
    ..study include the eyes, optic nerves, optic chiasm, pituitary gland, and brainstem (spinal cord, medulla oblongota, pons, and mid brain)...
  38. THE DEVELOPMENTAL NEUROCHEMISTRY OF COCAINE
    Susan Robinson; Fiscal Year: 1992
    ..Brain areas to be analyzed are frontal cortex, parietal cortex, hippocampus, striatum, hypothalamus, and medulla-pons. Behavioral testing will consist of measuring weight gain, simple reflexes, locomotor activity and habituation...
  39. BRAINSTEM MECHANISMS OF ALERTING
    ADRIAN MORRISON; Fiscal Year: 2002
    ..of the activity of nerve cells in the amygdala of the forebrain of rats and their interactions with those in the pons of the hindbrain that have long been studied and heavily implicated in the control of REM...
  40. INPUT/OUTPUT RELATIONSHIPS IN VISUAL CORTEX
    Gillian Einstein; Fiscal Year: 1993
    ..from three regions known to play different roles in the processing of visual information, the superior colliculus, pons, and ipsilateral striate cortex...
  41. DEVELOPMENTAL EXPRESSION OF GABA-A RECEPTOR MRNAS
    RUTH SIEGEL; Fiscal Year: 2003
    ..Studies will be performed on cerebellar slices grown in the presence or absence of pons explants, a source of excitatory mossy fiber input found in vivo...
  42. STRUCTURE/FUNCTION OF A NOVEL ACTIN BINDING PROTEIN
    Anne Hitt; Fiscal Year: 2002
    ..of the proposed research are: (1) To construct and express a genetically engineered synthetic ponticulin gene, ponS; (2) To identify the F-actin binding site in ponticulin by site- directed mutagenesis of ponsS, coupled with ..
  43. Mechanisms Underlying the Cognitive Function of Sleep
    Subimal Datta; Fiscal Year: 2009
    ....
  44. Molecular Control of Reticulospinal Neuron Development
    Samuel Pfaff; Fiscal Year: 2003
    ..Two large groups of reticulospinal neurons have been described in the mammalian brainstem, one in the pons and the other in the medulla...
  45. TRIGGERING & INHIBITION OF THE STARTLE RESPONSE
    Jerome Siegel; Fiscal Year: 1990
    ..We will similarly investigate a second group of cells, localized to the dorsolateral pons and medial medulla...
  46. CHEMORECEPTOR INPUT TO NON-RESPIRATORY CELLS IN NTS
    STEVEN MIFFLIN; Fiscal Year: 2007
    ..Abolition of PHFD, which depends upon neurons in the ventro-lateral pons overlapping the A5 noradrenergic cell group, and reduced GABA inhibition of NTS neurons, could contribute to the ..
  47. THE CONTROL OF DESYNCHRONIZED SLEEP
    CARL KING; Fiscal Year: 1980
    It has been proposed that the sleep cycle is actively generated by two interrelated cell aggregations in the rostral pons: the locus coeruleus and the nearby giant cells of the pontine tegmentum...
  48. FMRI DEMONSTRATION OF OPIATE/NORADRENERGIC INTERACTIONS
    Randy Gollub; Fiscal Year: 1999
    ..Concerted effort will be made to directly demonstrate fMRI signal intensity change in the region of dorsal pons containing the majority of noradrenergic neurons...
  49. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2008
    ..abstract_text> ..
  50. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  51. GUSTATORY THALAMUS AND TASTE GUIDED BEHAVIOR
    STEPHEN REILLY; Fiscal Year: 2004
    ..The results of the research proposed in this application will significantly enhance our understanding of the information processing role(s) of the thalamic taste area of the rat. ..
  52. NEUROTROPHIN CONTROL OF REM SLEEP
    Jack Yamuy; Fiscal Year: 2004
    ..This concerted set of experiments will be critical in elucidating the role that neurotrophins play in the control of REM sleep. ..
  53. PERIAQUEDUCTAL GRAY MODULATION OF SYMPATHETIC DRIVE
    Linda Hayward; Fiscal Year: 2002
    ..preganglionic neurons and produces rapid increases sympathetic outflow via interconnections with the ventrolateral pons (A5 region)...
  54. Neural Mechanisms of Inhibitory Classical Conditioning
    John Freeman; Fiscal Year: 2007
    ..The results of these studies may also lead to a better understanding of the functional pathology associated with various psychiatric disorders that involve deficits in behavioral inhibition. ..
  55. Supramedullary control of respiration
    Linda Hayward; Fiscal Year: 2007
    ..The central hypothesis to be tested by this proposal is that neurons in dorsal pons (the lateral parabrachial nucleus; LPBN) play a critical role in relaying respiratory responses evoked from the ..
  56. Integrative Models of Neural Adaptive Control
    Chi Sang Poon; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  57. THE CPA: SOMATIC AND AUTONOMIC SYSTEMS
    W Panneton; Fiscal Year: 2004
    ..Understanding the brainstem mechanisms governing he vascular constriction after either of these somatic stimuli may provide a neurological explanation for this. Such knowledge may lead to an understanding of essential hypertension. ..
  58. FMR Imaging of Eye Stabilization Processes
    CLAUDIO BUSETTINI; Fiscal Year: 2004
    ..abstract_text> ..
  59. Neuromorphic Electronic Model of Synaptic Plasticity
    Chi Sang Poon; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  60. Xth Oxford Conference on Modeling and Control of Breathing
    Chi Sang Poon; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  61. DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS
    Patricia Sue Grigson; Fiscal Year: 2010
    ..e., cocaine and heroin);and (c) Reveal that the nucleus accumbens depends upon an intact thalamocoritical loop to track cocaine's devaluation of a sweet. ..
  62. Nonlinear Analysis of Heart Rate Variability
    Chi Sang Poon; Fiscal Year: 2009
    ..These clinical and modeling studies in turn will showcase the proposed analytical techniques thereby paving the way for their application to other complex biomedical modeling and analysis problems in general. ..
  63. Opiate Addiction and HIV-1 Induced Release of Cytokines
    William Banks; Fiscal Year: 2006
    ....
  64. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2008
    ..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apnea" or the "sudden infant death syndrome." [unreadable] [unreadable] [unreadable]..
  65. Neural organization of eye movements in depth
    CLAUDIO BUSETTINI; Fiscal Year: 2009
    ....