red nucleus

Summary

Summary: A pinkish-yellow portion of the midbrain situated in the rostral mesencephalic tegmentum. It receives a large projection from the contralateral half of the CEREBELLUM via the superior cerebellar peduncle and a projection from the ipsilateral MOTOR CORTEX.

Top Publications

  1. ncbi Functional connectivity of the human red nucleus in the brain resting state at 3T
    C Nioche
    Service de Radiologie, Hopital du Val de Grace, Paris, France
    AJNR Am J Neuroradiol 30:396-403. 2009
  2. pmc Do spinocerebellar neurones forward information on spinal actions of neurones in the feline red nucleus?
    E Jankowska
    Department Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Goteborg, Sweden
    J Physiol 589:5727-39. 2011
  3. ncbi A three-dimensional histological atlas of the human basal ganglia. II. Atlas deformation strategy and evaluation in deep brain stimulation for Parkinson disease
    Eric Bardinet
    Centre National de la Recherche Scientifique, Unité Propre de Recherche 640, Laboratoire de Neuroscience et Imagerie Cognitive, Paris, France
    J Neurosurg 110:208-19. 2009
  4. pmc Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain
    Nilima Prakash
    Helmholtz Centre Munich, German Research Centre for Environmental Health GmbH and Technical University Munich, Institute of Developmental Genetics, Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Munich Neuherberg, Germany
    Development 136:2545-55. 2009
  5. ncbi Shh dependent and independent maintenance of basal midbrain
    Ariadna Perez-Balaguer
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Mech Dev 126:301-13. 2009
  6. ncbi Amygdala, deep cerebellar nuclei and red nucleus contribute to delay eyeblink conditioning in C57BL /6 mice
    Toshiro Sakamoto
    Laboratory of Behavioral Neuroendocrinology, Graduate School of Comprehensive Human Science, University of Tsukuba, Japan
    Eur J Neurosci 32:1537-51. 2010
  7. ncbi The mammalian red nucleus and its role in motor systems, including the emergence of bipedalism and language
    T Philip Hicks
    Department of Biology and Faculty of Graduate Studies, Lakehead University, Canada
    Prog Neurobiol 96:165-75. 2012
  8. ncbi Interleukin-10 of red nucleus plays anti-allodynia effect in neuropathic pain rats with spared nerve injury
    Zhi Hong Wang
    Department of Immunology and Pathogenic Biology, Xi an Jiaotong University College of Medicine, Xi an, 710061 Shaanxi, People s Republic of China
    Neurochem Res 37:1811-9. 2012
  9. ncbi Changes in red nucleus after pyramidal tract injury in patients with cerebral infarct
    Sang Seok Yeo
    Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Republic of Korea
    NeuroRehabilitation 27:373-7. 2010
  10. ncbi Red nucleus neurons actively contribute to the acquisition of classically conditioned eyelid responses in rabbits
    Renny Pacheco-Calderón
    Division of Neurosciences, Pablo de Olavide University, Seville 41013, Spain
    J Neurosci 32:12129-43. 2012

Research Grants

Detail Information

Publications198 found, 100 shown here

  1. ncbi Functional connectivity of the human red nucleus in the brain resting state at 3T
    C Nioche
    Service de Radiologie, Hopital du Val de Grace, Paris, France
    AJNR Am J Neuroradiol 30:396-403. 2009
    ..with diffusion tensor imaging axonal tracking have demonstrated possible in vivo connections between the human red nucleus (RN) and the sensorimotor and associative cortical areas...
  2. pmc Do spinocerebellar neurones forward information on spinal actions of neurones in the feline red nucleus?
    E Jankowska
    Department Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Goteborg, Sweden
    J Physiol 589:5727-39. 2011
    ..The aim of the present study was to examine whether VSCT neurones likewise monitor descending commands from the red nucleus (RN)...
  3. ncbi A three-dimensional histological atlas of the human basal ganglia. II. Atlas deformation strategy and evaluation in deep brain stimulation for Parkinson disease
    Eric Bardinet
    Centre National de la Recherche Scientifique, Unité Propre de Recherche 640, Laboratoire de Neuroscience et Imagerie Cognitive, Paris, France
    J Neurosurg 110:208-19. 2009
    ..The aim of this study was to develop an automated method of adapting an atlas of the human basal ganglia to the brains of individual patients...
  4. pmc Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain
    Nilima Prakash
    Helmholtz Centre Munich, German Research Centre for Environmental Health GmbH and Technical University Munich, Institute of Developmental Genetics, Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Munich Neuherberg, Germany
    Development 136:2545-55. 2009
    ..We show that Otx2 provides the crucial anterior-posterior positional information for the generation of red nucleus neurons in the murine midbrain...
  5. ncbi Shh dependent and independent maintenance of basal midbrain
    Ariadna Perez-Balaguer
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Mech Dev 126:301-13. 2009
    ..We report that the oculomotor complex is lost, the dopaminergic populations are strongly affected but the red nucleus is maintained...
  6. ncbi Amygdala, deep cerebellar nuclei and red nucleus contribute to delay eyeblink conditioning in C57BL /6 mice
    Toshiro Sakamoto
    Laboratory of Behavioral Neuroendocrinology, Graduate School of Comprehensive Human Science, University of Tsukuba, Japan
    Eur J Neurosci 32:1537-51. 2010
    ..eyeblink conditioning in mice, we examined the roles of the deep cerebellar nuclei (DCN), the amygdala and the red nucleus (RN) through the use of electrolytic lesions and reversible inactivation...
  7. ncbi The mammalian red nucleus and its role in motor systems, including the emergence of bipedalism and language
    T Philip Hicks
    Department of Biology and Faculty of Graduate Studies, Lakehead University, Canada
    Prog Neurobiol 96:165-75. 2012
    The human red nucleus consists of the well-developed parvicellular red nucleus (pNr) and the rudimentary magnocellular red nucleus (mNr)...
  8. ncbi Interleukin-10 of red nucleus plays anti-allodynia effect in neuropathic pain rats with spared nerve injury
    Zhi Hong Wang
    Department of Immunology and Pathogenic Biology, Xi an Jiaotong University College of Medicine, Xi an, 710061 Shaanxi, People s Republic of China
    Neurochem Res 37:1811-9. 2012
    ..shown that pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β) in red nucleus (RN) are involved in the development of neuropathic pain and play facilitated roles on the mechanical allodynia ..
  9. ncbi Changes in red nucleus after pyramidal tract injury in patients with cerebral infarct
    Sang Seok Yeo
    Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Republic of Korea
    NeuroRehabilitation 27:373-7. 2010
    We investigated red nucleus (RN) changes in patients with a cerebral infarct, using diffusion tensor imaging (DTI). Forty-nine consecutive stroke patients with pyramidal tract(PT) injury (mean age, 62...
  10. ncbi Red nucleus neurons actively contribute to the acquisition of classically conditioned eyelid responses in rabbits
    Renny Pacheco-Calderón
    Division of Neurosciences, Pablo de Olavide University, Seville 41013, Spain
    J Neurosci 32:12129-43. 2012
    The red nucleus (RN) is a midbrain premotor center that has been suggested as being involved in the acquisition and/or performance of classically conditioned nictitating membrane/eyelid responses...
  11. pmc Higher iron in the red nucleus marks Parkinson's dyskinesia
    Mechelle M Lewis
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA 17033 0850, USA
    Neurobiol Aging 34:1497-503. 2013
    ..Because the red nucleus (RN) mediates cerebellar circuitry, we hypothesized that RN iron changes might reflect cerebellum-related ..
  12. ncbi The red nucleus and the rubrospinal projection in the mouse
    Huazheng Liang
    Neuroscience Research Australia, Sydney, NSW, 2031, Australia
    Brain Struct Funct 217:221-32. 2012
    We studied the organization and spinal projection of the mouse red nucleus with a range of techniques (Nissl stain, immunofluorescence, retrograde tracer injections into the spinal cord, anterograde tracer injections into the red nucleus,..
  13. ncbi Reliability of atlas-derived coordinates in deep brain stimulation
    J Schlaier
    Department of Neurosurgery, University of Regensburg, Germany
    Acta Neurochir (Wien) 147:1175-80; discussion 1180. 2005
    ..The objective of our study was to investigate the reliability of atlas derived data by comparing them with direct targeting on MR images...
  14. ncbi Cytoarchitecture, morphology, and lumbosacral spinal cord projections of the red nucleus in cattle
    Roberto Chiocchetti
    Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, 40064 Ozzano dell Emilia, Bologna, Italy
    Am J Vet Res 67:1662-9. 2006
    To analyze the morphology, cytoarchitecture, and lumbosacral spinal cord projections of the red nucleus (RN) in cattle.
  15. ncbi Magnetic resonance imaging-based morphometry and landmark correlation of basal ganglia nuclei
    X L Zhu
    Department Neurosurgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, PR China
    Acta Neurochir (Wien) 144:959-69; discussion 968-9. 2002
    ..of 35 patients served for retrospective morphometric analysis of different basal ganglia nuclei (STN, GP, red nucleus, and substantia nigra) and several anatomical landmarks (anterior and posterior commissure, maximum width of ..
  16. ncbi Subthalamic and red nucleus volumes in patients with Parkinson's disease: do they change with disease progression?
    Mustafa Efkan Colpan
    Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
    Parkinsonism Relat Disord 16:398-403. 2010
    To examine a possible correlation between disease progression and the volumes of the subthalamic nucleus (STN) and red nucleus (RN) in patients with Parkinson disease (PD).
  17. ncbi Adeno-associated viral vector (AAV)-mediated gene transfer in the red nucleus of the adult rat brain: comparative analysis of the transduction properties of seven AAV serotypes and lentiviral vectors
    Bas Blits
    Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47 1105 BA Amsterdam, The Netherlands
    J Neurosci Methods 185:257-63. 2010
    ..seven AAV serotypes in young adult rats following a single injection in a major nucleus of the mid brain, the red nucleus, which is the origin of the rubrospinal tract...
  18. ncbi Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration
    C A Tobias
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Exp Neurol 184:97-113. 2003
    ..grafts, but not the control grafts, significantly reduced retrograde degeneration and atrophy in the injured red nucleus. Grafts of BDNF + NT-3 expressing fibroblasts delayed 6 weeks after injury therefore elicit growth from intact ..
  19. pmc Carbocyanine dye usage in demarcating boundaries of the aged human red nucleus
    Satoru Onodera
    Department of Anatomy, School of Medicine, Iwate Medical University, Morioka, Japan
    PLoS ONE 5:e14430. 2010
    Though the adult human magnocellular Red nucleus (mNr) is essentially vestigial and its boundaries with neighbouring structures have never been well demarcated, human studies in utero have shown a well developed semilunar mNr wrapping ..
  20. ncbi Paw and limb use in skilled and spontaneous reaching after pyramidal tract, red nucleus and combined lesions in the rat: behavioral and anatomical dissociations
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Behav Brain Res 93:167-83. 1998
    The pyramidal tract and red nucleus send prominent projections to the spinal cord and are thought to co-operate in producing skilled movements...
  21. ncbi Distinct temporal activity patterns in the rat M1 and red nucleus during skilled versus unskilled limb movement
    L Hermer-Vazquez
    Department of Physiology and Pharmacology, SUNY Health Science Center, Room 5 5, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Behav Brain Res 150:93-107. 2004
    ..We obtained simultaneous multi-single neuron recordings from the forelimb motor cortex and magnocellular red nucleus as rats performed two contextually different, but kinematically similar, forelimb reach-like tasks: highly ..
  22. ncbi Red nucleus lesions impair overground locomotion in rats: a kinetic analysis
    G D Muir
    Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Eur J Neurosci 12:1113-22. 2000
    The red nucleus is a prominent brainstem nucleus in mammals which is thought to be involved in production of skilled limb movements...
  23. ncbi Nerve growth factor of red nucleus involvement in pain induced by spared nerve injury of the rat sciatic nerve
    Yuan Yuan Jing
    Department of Immunology and Pathogenic Biology, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi, PR China
    Neurochem Res 34:1612-8. 2009
    ..The results showed that the level of NGF in the Red nucleus (RN) of SNI rats was apparently higher than that of sham-operated rats...
  24. ncbi Tumor necrosis factor-α of Red nucleus involved in the development of neuropathic allodynia
    Xiaoli Li
    Department of Immunology and Pathogenic Biology, Xi an Jiaotong University School of Medicine, Xi an 710061, Shaanxi, People s Republic of China
    Brain Res Bull 77:233-6. 2008
    ..Two weeks following SNI, the immunohistochemical results identified that the expression level of TNF-α in the Red nucleus (RN) of SNI rats was apparently higher than that of sham-operated rats...
  25. ncbi An allele of the mouse mutant dystonia musculorum exhibits lesions in red nucleus and striatum
    A Messer
    Neuroscience 5:543-9. 1980
  26. ncbi Interleukin-1 beta of Red nucleus involved in the development of allodynia in spared nerve injury rats
    Zhihong Wang
    Department of Immunology and Pathogenic Biology, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi, 710061, People s Republic of China
    Exp Brain Res 188:379-84. 2008
    ..The results showed that immunoreactive-like IL-1 beta protein was significantly elevated in the Red nucleus (RN) 2 weeks after SNI...
  27. ncbi Differential expression of calcium-binding proteins in the red nucleus of the developing and adult human brain
    N Ulfig
    Department of Anatomy, University of Rostock, Germany
    Anat Embryol (Berl) 203:95-108. 2001
    The adult human red nucleus consists of two parts: (1) the parvocellular part, which is clearly separated from (2) the magnocellular part. The latter and its rubrospinal projection is known to be rudimentary in the adult human brain...
  28. ncbi Discharge characteristics of neurons in the red nucleus during voluntary gait modifications: a comparison with the motor cortex
    Sylvain Lavoie
    Department of Physiology, University of Montreal, Montreal, Quebec H3C 3J7, Canada
    J Neurophysiol 88:1791-814. 2002
    We have examined the contribution of the red nucleus to the control of locomotion in the cat...
  29. ncbi Development of the human magnocellular red nucleus: a morphological study
    Katsuyuki Yamaguchi
    Department of Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    Brain Dev 28:431-5. 2006
    The development of the human magnocellular red nucleus (RNm) was studied in 20 fetuses at 12-39 weeks of gestation (WG). With microscopic observation on serial sections of the brain, we measured the profile area of a neuronal cell body...
  30. ncbi Cerebellar input to magnocellular neurons in the red nucleus of the mouse: synaptic analysis in horizontal brain slices incorporating cerebello-rubral pathways
    M C Jiang
    Neuroscience 110:105-21. 2002
    ..studied the synaptic input from the nucleus interpositus of the cerebellum to the magnocellular division of the red nucleus (RNm) in the mouse using combined electrophysiological and neuroanatomical methods...
  31. ncbi Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus
    N Ulfig
    Department of Anatomy, Neuroembryonic Research Laboratory, University of Rostock, Germany
    Neurosignals 11:95-102. 2002
    ..study showed that in the human fetal and neonatal brain, the magnocellular and parvocellular parts of the red nucleus can be well delineated by calcium-binding proteins...
  32. ncbi Undesired effects of a combinatorial treatment for spinal cord injury--transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus
    Frederic Bretzner
    ICORD International Collaboration on Repair Discoveries, Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Eur J Neurosci 28:1795-807. 2008
    ..Hence, some combinatorial treatments, such as OECs with BDNF, may have undesired effects in the injured spinal cord...
  33. ncbi Discharge of primate magnocellular red nucleus neurons during reaching to grasp in different spatial locations
    Peter L E van Kan
    Department of Kinesiology, Room 3195, Medical Sciences Center, University of Wisconsin, Madison, 1300 University Avenue, Madison, WI 53706 1532, USA
    Exp Brain Res 142:151-7. 2002
    ..An important source of origin of the rubrospinal tract is the magnocellular red nucleus (RNm). Forelimb RNm neurons discharge vigorously during reach-to-grasp movements...
  34. ncbi Class A plexin expression in axotomized rubrospinal and facial motoneurons
    E D Spinelli
    International Collaboration on Repair Discoveries, 6270 University Boulevard, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Neuroscience 144:1266-77. 2007
    ..Hence, there are distinct expression patterns of the individual plexin-A family members suggesting that regenerating rubrospinal and facial motoneurons have a differential ability to transduce semaphorin signals...
  35. ncbi Extinction of a classically conditioned response: red nucleus and interpositus
    Karla Robleto
    University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 28:2651-8. 2008
    ..In this study, we looked at the involvement of the interpositus and the red nucleus in extinction...
  36. ncbi Integrin messenger RNAs in the red nucleus after axotomy and neurotrophic administration
    Stefan Plantman
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Neuroreport 16:709-13. 2005
    ..We have investigated the expression of integrin messenger RNAs in red nucleus neurons of adult rats after axotomy and administration of neurotrophic factors...
  37. ncbi Cortical projections to the human red nucleus: a diffusion tensor tractography study with a 1.5-T MRI machine
    Christophe Habas
    Service de NeuroImagerie, Centre Hospitalier National d Optalmologie des Quinze Vingts, Universite Pierre et Marie Curie Paris 6, Paris, France
    Neuroradiology 48:755-62. 2006
    Previous studies in apes and monkeys have shown that the red nucleus receives projections from the sensorimotor and premotor cortices, whereas other experiments carried out with injured human brains have found corticorubral projections ..
  38. ncbi Facilitation of the jaw reflexes by stimulation of the red nucleus in the rat
    Yoshihide Satoh
    Department of Physiology, School of Dentistry at Niigata, The Nippon Dental University, 1 8 Hamaura cho, Niigata 951 8580, Japan
    Brain Res 978:51-8. 2003
    The effects of the red nucleus (RN) stimulation on the jaw-opening reflex (JOR) and the masseteric monosynaptic reflex (MMR) were studied in anesthetized rats. The JOR was evoked by electrical stimulation of the inferior alveolar nerve...
  39. ncbi An investigation into the potential for activity-dependent regeneration of the rubrospinal tract after spinal cord injury
    Philip J Harvey
    Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Eur J Neurosci 22:3025-35. 2005
    ..In summary, direct stimulation of the injured RST axons for the periods tested does not increase expression of GAP-43 and BDNF, and ultimately does not promote regeneration of these central nervous system axons...
  40. ncbi Contribution of primate magnocellular red nucleus to timing of hand preshaping during reaching to grasp
    Peter L E van Kan
    Department of Kinesiology, Medical Sciences Center Rm 3195, University of Wisconsin, 1300 University Avenue, Madison, WI 53706 1532, USA
    J Neurophysiol 87:1473-87. 2002
    Magnocellular red nucleus (RNm) is involved in controlling goal-directed limb movements such as reaching to grasp. We tested two hypotheses related to RNm's role in controlling reach-to-grasp movements...
  41. ncbi Close axonal injury of rubrospinal neurons induced transient perineuronal astrocytic and microglial reaction that coincided with their massive degeneration
    Pei Hsin Liu
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Exp Neurol 179:111-26. 2003
    ..In effect, this might in part determine neuronal fate following axonal injury...
  42. pmc A comparative neuroanatomical study of the red nucleus of the cat, macaque and human
    Satoru Onodera
    Department of Anatomy, School of Medicine, Iwate Medical University, Morioka, Japan
    PLoS ONE 4:e6623. 2009
    The human red nucleus (Nr) is comparatively less well-studied than that of cats or monkeys...
  43. ncbi Functional specialization within the cat red nucleus
    K M Horn
    Division of Neurobiology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurophysiol 87:469-77. 2002
    Magnocellular (RNm) and parvicellular (RNp) divisions of the cat red nucleus (RN) project to the cervical spinal cord. RNp projects more heavily to upper cervical levels and RNm projects more heavily to lower levels...
  44. ncbi Role of primate magnocellular red nucleus neurons in controlling hand preshaping during reaching to grasp
    P L van Kan
    Department of Kinesiology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
    J Neurophysiol 85:1461-78. 2001
    ..We aimed to clarify the role of cerebellar output via the magnocellular red nucleus (RNm) to the control of reaching to grasp...
  45. ncbi Neuronal activity of the red nucleus in Parkinson's disease
    Maria C Rodriguez-Oroz
    Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, Neuroscience Division, CIMA, University of Navarra, Pamplona, Spain
    Mov Disord 23:908-11. 2008
    ..of the electrodes during surgery in 2 patients with PD, we have characterized the neuronal firing in the red nucleus (RN) and observed the effects of stimulation of this nucleus...
  46. ncbi Development of the human parvocellular red nucleus. A morphological study
    Katsuyuki Yamaguchi
    Department of Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    Dev Neurosci 30:325-30. 2008
    Morphology of the human parvocellular red nucleus (RNp) was investigated in 14 fetuses aged from 12 to 39 weeks of gestation (WG). The brains were processed into celloidin-embedded serial sections...
  47. ncbi Spinal projections of the cat parvicellular red nucleus
    Milton Pong
    Division of Neurobiology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurophysiol 87:453-68. 2002
    Traditionally, the red nucleus of the cat is divided into two parts: a large-celled, magnocellular, division (RNm) and a small-celled, parvicellular, division (RNp)...
  48. pmc Survival and regeneration of rubrospinal neurons 1 year after spinal cord injury
    Brian K Kwon
    CORD Collaboration On Repair Discoveries, University of British Columbia, Room 2469, Biosciences Building, 6270 University Boulevard, Vancouver, BC, Canada V6T 1Z4
    Proc Natl Acad Sci U S A 99:3246-51. 2002
    ..This outcome is a demonstration of the regenerative capacity of spinal cord projection neurons a full year after axotomy...
  49. ncbi Injury-induced class 3 semaphorin expression in the rat spinal cord
    F De Winter
    Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, Amsterdam, 1105 AZ, The Netherlands
    Exp Neurol 175:61-75. 2002
    ..Future studies will focus on the neutralization of class 3 semaphorins, in order to reveal whether this creates a more permissive environment for regeneration of injured spinal cord axons...
  50. ncbi Red nucleus projections to distinct motor neuron pools in the rat spinal cord
    Martin Küchler
    Brain Research Institute, University and ETH Zurich, Zurich 8057, Switzerland
    J Comp Neurol 448:349-59. 2002
    ..Microstimulation of the red nucleus resulted in electromyographic responses with shorter latency in the distal forelimb muscles than in proximal ..
  51. pmc Cessation of activity in red nucleus neurons during stimulation of the medial medulla in decerebrate rats
    Boris Y Mileykovskiy
    Veterans Administration, Greater Los Angeles Health System, Sepulveda, California, USA
    J Physiol 545:997-1006. 2002
    ..stimulation of Gi and DPGi inhibitory sites on the activity of neurons located in the magnocellular part of the red nucleus (RMC), a cell group that participates in both the tonic and phasic regulation of motor output...
  52. ncbi Apparent diffusion coefficients in spinal cord transplants and surrounding white matter correlate with degree of axonal dieback after injury in rats
    Eric D Schwartz
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia 191047, USA
    AJNR Am J Neuroradiol 26:7-18. 2005
    ..We proposed that ADC values would correlate with quantitative axonal tracing in the transected rubrospinal tract (RST)...
  53. ncbi Glutathione monoethyl ester improves functional recovery, enhances neuron survival, and stabilizes spinal cord blood flow after spinal cord injury in rats
    G Guizar-Sahagun
    Research Unit for Neurological Diseases, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    Neuroscience 130:639-49. 2005
    ..These results support further investigation of reduced glutathione supplementation after acute SC injury for future clinical application...
  54. ncbi Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice
    Yona Goldshmit
    Center for Neuroscience and School of Physiotherapy, University of Melbourne, Melbourne, Victoria 3010, Australia
    J Neurosci 24:10064-73. 2004
    ..Thus, EphA4 regulates two important features of spinal cord injury, axonal inhibition, and astrocytic gliosis...
  55. ncbi Galectin-1 expression correlates with the regenerative potential of rubrospinal and spinal motoneurons
    J McGraw
    International Collaboration on Repair Discoveries, 6270 University Boulevard, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Neuroscience 128:713-9. 2004
    ..Thus, the expression of galectin-1 in neurons correlates with the regenerative propensity...
  56. ncbi Rubrospinal neurons fail to respond to brain-derived neurotrophic factor applied to the spinal cord injury site 2 months after cervical axotomy
    Brian K Kwon
    International Collaboration on Repair Discoveries ICORD, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4
    Exp Neurol 189:45-57. 2004
    ..The red nucleus was examined for reversal of neuronal atrophy, GAP43 and Talpha1 tubulin mRNA expression, and trkB receptor ..
  57. ncbi The proximity of the lesion to cell bodies determines the free radical risk induced in rat rubrospinal neurons subjected to axonal injury
    P H Liu
    Department of Anatomy, College of Medicine, Tzu Chi University, No 701, Section 3, Chung Yan Road, 970, Hualien, Taiwan, Republic of China
    Anat Embryol (Berl) 207:439-51. 2004
    ..Based on these, we proposed that besides the NO-overproduction-induced toxicity, superoxide-loading-induced mitochondrial damage also added to hampering the survival of the closely axotomized neurons...
  58. ncbi Spinal axonal injury transiently elevates the level of metabotropic glutamate receptor 5, but not 1, in cord-projection central neurons
    Yueh Jan Wang
    Department of Anatomy, College of Medicine, Tzu Chi University, Taiwan
    J Neurotrauma 21:479-89. 2004
    ..Their decrease following rubrospinal axotomy suggests that axonal injury may also compromise the presynaptic regulation of afferent activities onto injured cord-projection central neurons...
  59. ncbi Protective effects of adenoviral cardiotrophin-1 gene transfer on rubrospinal neurons after spinal cord injury in adult rats
    Zhang Feng Zhang
    Department of Neurotrauma, Research Institute of Surgery, Third Military Medical University, Chongqing 400042, P R China
    Neurotox Res 5:539-48. 2003
    ..Behavioral testing revealed a significant functional recovery in limb usage. This observation indicated that adenoviral CT-1 gene transfer into the injured cord promoted survival and regeneration of rubrospinal neurons in adult rats...
  60. pmc Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions
    Sebastian Breuer
    Department of Neurology, University Medical School, Pauwelsstr 30, D 52074 Aachen, Germany
    BMC Neurosci 5:15. 2004
    ..This enzyme is needed for the conversion of stearate into oleate. Beside its role in membrane synthesis, oleate could act as a neurotrophic factor, involved in signal transduction pathways via activation of protein kinases C...
  61. ncbi Electrophysiological actions of the rubrospinal tract in the anaesthetised rat
    Sarah Al-Izki
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Exp Neurol 212:118-31. 2008
    ..In anaesthetised rats with neuromuscular blockade, a tungsten microelectrode was located in the region of the red nucleus (RN) by combining stereotaxis with recording of antidromic potentials evoked from the contralateral spinal cord...
  62. ncbi Fate of rubrospinal neurons after unilateral section of the cervical spinal cord in adult macaque monkeys: effects of an antibody treatment neutralizing Nogo-A
    P Wannier-Morino
    Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Chemin du Musee 5, Fribourg, Switzerland
    Brain Res 1217:96-109. 2008
    ..the effects of a spinal cord injury on the number and size of the neurons in the magnocellular part of the red nucleus (RNm), the origin of the rubrospinal tract, and evaluates whether a neutralization of Nogo-A reduces the ..
  63. ncbi Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury
    Marc J Ruitenberg
    Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam ZO, The Netherlands
    Neurobiol Dis 15:394-406. 2004
    ..the first time that AAV vectors can be used for the persistent transduction of highly atrophic neurons in the red nucleus (RN) for up to 18 months after injury...
  64. ncbi Glial fibrillary acidic protein expression in the hamster red nucleus: effects of axotomy and testosterone treatment
    Paul D Storer
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Maywood, IL 60153, USA
    Exp Neurol 184:939-46. 2003
    ..the potential influences of steroid hormones on centrally projecting motoneurons, the astrocyte reaction in the red nucleus was examined...
  65. ncbi BYHWD rescues axotomized neurons and promotes functional recovery after spinal cord injury in rats
    An Chen
    Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, China
    J Ethnopharmacol 117:451-6. 2008
    ..Buyang Huanwu Decoction (BYHWD), a Chinese prescription that has been used for hundreds of years to treat paralysis, has gained attention recently due to its significant neuroprotective properties...
  66. ncbi Spinal axonal injury induces brief downregulation of ionotropic glutamate receptors and no stripping of synapses in cord-projection central neurons
    Yueh Jan Wang
    Department of Anatomy, College of Medicine, Tzu Chi University, Hualien, Taiwan
    J Neurotrauma 21:1624-39. 2004
    ..Although this may support neurons by providing trophic influences, it nevertheless may subject them to excitotoxicity and ultimately lead to their degenerative fate...
  67. ncbi Effect of orofacial motor cortex stimulation on neuronal activity in the red nucleus
    Yoshihide Satoh
    Department of Physiology, The Nippon Dental University School of Life Dentistry at Niigata, 1 8 Hamaura cho, Niigata 951 8580, Japan
    Brain Res 1123:119-24. 2006
    We studied modulation of the activities of the red nucleus (RN) neurons under to electrical stimulation of the orofacial motor cortex (OfM) in urethane-anesthetized rats...
  68. ncbi Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip
    Andrew J Fink
    Department of Pathology Neuropathology, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 26:3066-76. 2006
    ....
  69. ncbi Human adult olfactory neural progenitors promote axotomized rubrospinal tract axonal reinnervation and locomotor recovery
    Ming Xiao
    Department of Human Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, 210029 China
    Neurobiol Dis 26:363-74. 2007
    ..These results highlight the unique potential of human olfactory neuroepithelial-derived progenitors as an autologous cell source for spinal cord repair...
  70. ncbi Profound differences in spontaneous long-term functional recovery after defined spinal tract lesions in the rat
    William T J Hendriks
    Department of Neuroregeneration, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    J Neurotrauma 23:18-35. 2006
    ..This is important for studies that employ pharmacological, cell-, and/or gene therapy- based interventions to improve axonal regeneration and functional recovery after spinal cord injury...
  71. ncbi Expression of Semaphorin3C in axotomized rodent facial and rubrospinal neurons
    Loren W Oschipok
    ICORD International Collaboration on Repair Discoveries, 6270 University Boulevard, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Neurosci Lett 434:113-8. 2008
    ..This demonstrates that increased Sema3C mRNA levels in axotomized rubrospinal neurons is common to both mouse and rat injury models...
  72. ncbi Delayed transplantation with exogenous neurotrophin administration enhances plasticity of corticofugal projections after spinal cord injury
    Dmitri E Iarikov
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurotrauma 24:690-702. 2007
    ..transplants and neurotrophins (BDNF or NT-3) increased the extent of the traced fibers crossing to the right red nucleus (RN), of which the axons are spared by a right cervical overhemisection lesion...
  73. ncbi Neuroimmunophilin ligands improve functional recovery and increase axonal growth after spinal cord hemisection in rats
    Jan Voda
    Center for Research on Occupational and Environmental Toxicology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    J Neurotrauma 22:1150-61. 2005
    ..and FK1706-treated rats demonstrate a significantly greater number of retrogradely labeled neurons in the red nucleus. The results implicate a nonimmunosuppressant mechanism in FK506's action and suggest that FK506 or a ..
  74. ncbi Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury
    Brian K Kwon
    International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 32:1164-73. 2007
    ..Experimental animal study...
  75. ncbi Distinct roles of oxidative stress and antioxidants in the nucleus dorsalis and red nucleus following spinal cord hemisection
    Mei Xu
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Brain Res 1055:137-42. 2005
    ..dorsalis (ND) that normally lacks expression of neuronal NO synthase (nNOS) in opposition to those in the red nucleus (RN) that constitutively expresses nNOS...
  76. ncbi Human adult olfactory neural progenitors rescue axotomized rodent rubrospinal neurons and promote functional recovery
    Ming Xiao
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Exp Neurol 194:12-30. 2005
    ..These results emphasize the unique potential of human olfactory neuroepithelial-derived progenitors as an autologous source of stem cells for spinal cord repair...
  77. ncbi Computation of inverse functions in a model of cerebellar and reflex pathways allows to control a mobile mechanical segment
    M Ebadzadeh
    Ecole Nationale Superieure des Telecommunications, CNRS URA 820, Département de Traitement des Signaux et des Images, 46 rue Barrault 75634 Paris 13, France
    Neuroscience 133:29-49. 2005
    ..These properties of these pathways allow to perform approximate inverse calculations after learning of direct functions, and insure also the coordination of voluntary and reflex motor orders...
  78. ncbi Control of fine movements mediated by propriospinal neurons
    E D Blagoveshchenskii
    Sensorimotor System Physiology Laboratory, A A Ukhtomskii Science Research Institute of Physiology, St Petersburg State University, 7 9 Universitetskaya Bank, 199034 St Petersburg, Russia
    Neurosci Behav Physiol 35:299-304. 2005
    ..In addition, the propriospinal system demonstrated a significant level of plasticity and was able to provide complete control of a number of fine voluntary movements...
  79. pmc The development of descending projections from the brainstem to the spinal cord in the fetal sheep
    Elaine M Stockx
    Ritchie Centre for Baby Health Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    BMC Neurosci 8:40. 2007
    ....
  80. pmc Nogo-66 receptor antagonist peptide (NEP1-40) administration promotes functional recovery and axonal growth after lateral funiculus injury in the adult rat
    Y Cao
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neurorehabil Neural Repair 22:262-78. 2008
    ..The authors used a similar design to examine recovery and repair after a lesion that interrupts the rubrospinal tract (RST)...
  81. ncbi Functional connectivity between the red nucleus and the hippocampus supports the role of hippocampal formation in sensorimotor integration
    Audny T Dypvik
    Dept of Psychology, Behavioral Neuroscience Research Group, Univ of Calgary, 2500 University Dr, NW, Calgary, Alberta T2N 1N4, Canada
    J Neurophysiol 92:2040-50. 2004
    Experiments were carried out in urethane-anesthetized rats to evaluate the hypothesis that the red nucleus has functional connections with the hippocampal formation...
  82. ncbi Treatment of chronically injured spinal cord with neurotrophic factors stimulates betaII-tubulin and GAP-43 expression in rubrospinal tract neurons
    Paul D Storer
    Department of Anatomy and Neurobiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Neurosci Res 74:502-11. 2003
    ..It is not clear from the present study how exogenous BDNF stimulates regrowth of injured axons...
  83. ncbi The organisation of spinal projecting brainstem neurons in an animal model of muscular dystrophy. A retrograde tracing study on mdx mutant mice
    D Carretta
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, I 50134, Florence, Italy
    Brain Res 895:213-22. 2001
    ..Our data further unveil the selective nature of mdx brain damage indicating a marked and selective involvement of the highest centers for motor control...
  84. ncbi Parvalbumin-containing neurons mediate the feedforward inhibition of rat rubrospinal neurons
    Chuen Lan Liu
    Department of Anatomy, Chung Shan Medical University, No 110, Section 1, Chien Kuo N Road, Taichung, Taiwan 402
    Anat Embryol (Berl) 205:245-54. 2002
    ..A group of cells with small to medium-sized cell bodies that reacted positively to both were found in the red nucleus and its immediate vicinity...
  85. ncbi Descending systems contributing to locomotor recovery after mild or moderate spinal cord injury in rats: experimental evidence and a review of literature
    D Michele Basso
    Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus 43210, USA
    Restor Neurol Neurosci 20:189-218. 2002
    ..Greater axonal sparing is associated with more extensive recovery. Therefore, we identified the source and relative proportion of spared axons associated with extensive or limited locomotor recovery after SCI...
  86. ncbi Reorganization of descending motor tracts in the rat spinal cord
    Olivier Raineteau
    Brain Research Institute, University and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Eur J Neurosci 16:1761-71. 2002
    ..b>Red nucleus microstimulation experiments confirmed the reorganization of the RST system...
  87. ncbi Distinctive patterns of connectivity between the zona incerta and the red nucleus of rats
    John Mitrofanis
    Institute for Biomedical Research, Department of Anatomy and Histology F13, University of Sydney, Sydney 2006, Australia
    Anat Embryol (Berl) 205:283-9. 2002
    ..of the zona incerta of the thalamus, this study has examined the organisation of its connections with the red nucleus of the midbrain...
  88. ncbi Combination of gonadal steroid treatment and peripheral nerve grafting results in a peripheral motoneuron-like pattern of beta II-tubulin mRNA expression in axotomized hamster rubrospinal motoneurons
    Paul D Storer
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Maywood, IL 60153, USA
    J Comp Neurol 449:364-73. 2002
    ..rubrospinal system is essentially crossed and that injured RSMN concentrate in the ventrolateral region of the red nucleus. In the second experimental series, adult gonadectomized male hamsters were subjected to a right T1 hemisection,..
  89. ncbi The role of the ventrolateral nucleus of the thalamus in the switching of descending influences to motor activity in the rat
    V V Fanardzhyan
    Laboratory for Central Nervous System Physiology, L A Orbeli Institute of Physiology, Armenian National Academy of Sciences, Erevan
    Neurosci Behav Physiol 32:53-9. 2002
    ..of the rubrospinal tract on recovery of motor activity and operant reflexes disrupted by lesioning of the red nucleus was more apparent when lesioning was chemical than when lesioning was electrolytic...
  90. ncbi Function of the hypothalamo-pituitary-adrenocortical system during ontogenesis in rats with inherited stress-induced arterial hypertension
    V V Bulygina
    Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk
    Neurosci Behav Physiol 32:49-51. 2002
    ..Decreased reactions of the HPAS to emotional stress in adult HSIAH rats is not associated with loss of adrenal ACTH sensitivity...
  91. ncbi Functional recovery and regeneration of descending tracts in rats after spinal cord transection in infancy
    Y Wakabayashi
    Department of Frontier Surgical Therapeutics, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Spine (Phila Pa 1976) 26:1215-22. 2001
    ....
  92. ncbi Mesencephalic projections to the first cervical segment in the cat
    T Satoda
    Hiroshima University, School of Dentistry, Kasumi 1 2 3, Minami Ku, Hiroshima 734, Japan
    Exp Brain Res 144:397-413. 2002
    ..The majority of cells were found contralaterally in the superior colliculus and red nucleus, and ipsilaterally in and around the interstitial nucleus of Cajal (INC), in the cuneiform region, and in the ..
  93. pmc Identification of regeneration-associated genes after central and peripheral nerve injury in the adult rat
    Andreas B Schmitt
    Department of Neurology, Aachen University Medical School, Pauwelsstrasse 30, 52057 Aachen, Germany
    BMC Neurosci 4:8. 2003
    ..The underlying molecular programs initiated by axotomized peripheral and central nervous system neurons are not yet fully understood...
  94. ncbi Histamine elicits neuronal excitatory response of red nucleus in the rat via H2 receptors in vitro
    Kun Chen
    Department of Biological Science and Technology, Nanjing University, 22 Hankou Road, Nanjing 210093, China
    Neurosci Lett 351:25-8. 2003
    ..These results indicate that histamine excites red nucleus neurons through H2 receptors and suggest that the histaminergic afferent fibers may play an important ..
  95. ncbi betaII-tubulin and GAP 43 mRNA expression in chronically injured neurons of the red nucleus after a second spinal cord injury
    Paul D Storer
    Department of Anatomy and Neurobiology, University of Arkansas for Medical Sciences, Slot 510, 4301 W Markham St, Little Rock, AR 72205, USA
    Exp Neurol 183:537-47. 2003
    ..Using radioactive cDNA probes and in situ hybridization, RST neurons in the contralateral red nucleus were examined for changes in mRNA levels of betaII-tubulin and GAP 43 in an acute injury period (6 h-3 days), a ..
  96. ncbi Responses of the red nucleus neurons to limb stimulation after cerebellar lesions
    Remigiusz Tarnecki
    Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
    Cerebellum 2:96-100. 2003
    ..concerning the effects induced by unilateral cerebellar lesions on background activity and responses of red nucleus neurons contralateral to lesion sites are reported in this short review...
  97. ncbi Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: effects on rubrospinal tract regeneration, lesion size, and functional recovery after implantation in the injured rat spinal cord
    Marc J Ruitenberg
    Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ, Amsterdam, The Netherlands
    J Neurosci 23:7045-58. 2003
    ..Thus, our results demonstrate that genetic engineering of OEG not only resulted in a cell that was more effective in promoting axonal outgrowth but could also lead to enhanced recovery after injury, possibly by sparing of spinal tissue...
  98. ncbi Regional (14C) 2-deoxyglucose uptake during forelimb movements evoked by rat motor cortex stimulation: cortex, diencephalon, midbrain
    F R Sharp
    Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    J Comp Neurol 224:259-85. 1984
    ..Activated midbrain regions included ventromedial magnocellular red nucleus (RNm), posterior deep layers of the superior colliculus (SCsgp), lateral deep mesencephalic nucleus (DMN), ..
  99. ncbi Supplementary eye field as defined by intracortical microstimulation: connections in macaques
    M F Huerta
    Department of BioStructure and Function, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Comp Neurol 293:299-330. 1990
    ..nucleus, rostral interstitial nucleus of the medial longitudinal fasciculus, parvocellular part of the red nucleus, intermediate and deep layers of the superior colliculus, central gray, cuneiform nucleus, mesencephalic ..
  100. ncbi Multiplex in-cell reverse transcription-polymerase chain reaction for the simultaneous detection of p210 and p190 BCR-ABL mRNAs in chronic myeloid leukemia and Philadelphia-positive acute lymphoblastic leukemia cell lines
    S P Suh
    Department of Clinical Pathology, Chonnam National University Medical School, Kwangju, Korea
    Clin Chem Lab Med 38:939-44. 2000
    ..counterstaining showed that the positive K562 cells exhibited a yellow-green fluorescent cytoplasm around a red nucleus, and that the positive SUP B-15 cells exhibited an orange cytoplasm around a blue nucleus...
  101. ncbi Anatomical location of effective deep brain stimulation electrodes in chronic cluster headache
    Denys Fontaine
    Centre Hospitalier Universitaire de Nice Neurosurgery, Nice, France
    Brain 133:1214-23. 2010
    ..located <2 mm from the centres of effective contacts were: the mesencephalic grey substance (5/5), the red nucleus (4/5), the fascicle retroflexus (4/5), the fascicle longitudinal dorsal (3/5), the nucleus of ansa lenticularis ..

Research Grants39

  1. Characterization of the mechanisms underlying rubrospinal control of movement
    NALINI ANNE COLACO; Fiscal Year: 2011
    ..the molecular identity and anatomical organization of functionally distinct populations of neurons within the red nucleus. Molecular markers of the rubrospinal tract will be used to create genetic tools with which to visualize ..
  2. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian-Smith; Fiscal Year: 2012
    ..cortical fibers form new functional synapses (within the dorsal and ventral horn, cuneate nucleus and red nucleus), in response to a dorsal root lesion? EM analysis will be used to answer this question...
  3. Injury and adaptation in the developing rat corticospinal and rubrospinal tracts
    JASON BRANT CARMEL; Fiscal Year: 2013
    ..the CST through its sparse ipsilateral projections, and 2) a bypass circuit on the injured side from cortex to red nucleus to spinal cord...
  4. ACTIVITY REFINES CORTICOSPINAL TERMINATIONS
    John H Martin; Fiscal Year: 2011
    ..interneurons by the developing CST stimulated us to ask if there is co-development between the CST and the red nucleus, a target of the motor cortex...
  5. STUDIES OF THE CEREBELLAR DEEP NUCLEI
    Alvin Beitz; Fiscal Year: 1990
    ..with cerebellar afferent fibers that synapse on deep cerebellar nuclear neurons projecting to the thalamus, red nucleus or inferior olivary nucleus; 2) To determine whether the neurotransmitter associated with cerebellar climbing ..
  6. Influence of the Basal Ganglia on Cerebellar Action
    Alan Gibson; Fiscal Year: 2007
    ..We have discovered that disrupting activity in the cat red nucleus, which connects cerebellar output to the spinal cord, can produce motor symptoms that are strikingly similar to ..
  7. Spinal cord injury: plasticity and recovery of function
    Barbara S Bregman; Fiscal Year: 2010
    ..eorganization that occurs within representative supraspinal and spinal regions: sensorimotor cortex and red nucleus (supraspinal pathways associated with skilled movement), in raphespinal neurons (a pathway associated with ..
  8. TRANSPLANTATION OF HUMAN BONE MARROW STROMAL CELLS
    Itzhak Fischer; Fiscal Year: 2004
    ..to their survival, migration and phenotype as well as their ability to rescue axotomized neurons (in the Red Nucleus), promote axon regeneration (of corticospinal and rubrospinal tracts) and restore function (using cylinder, ..
  9. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2006
    ..As models we will examine reorganization in cortical and cerebellar afferents to the red nucleus, descending and segmental input to propriospinal neurons and sensory afferents to the dorsal column nuclei and ..
  10. NEURAL CONTROL OF TRAINED MOVEMENT
    WILLIAM THACH; Fiscal Year: 2007
    ..Project # 2 asks how the cerebellar cortex, inferior olive, and parvocellular red nucleus are involved in adapting and learning to touch a visual target that has shifted in mid-reach...
  11. Integrated Image Analysis System for Epilepsy
    Hamid Soltanian Zadeh; Fiscal Year: 2007
    ..distribution, texture, shape, surface area, and volume of) brain structures such as hippocampus, amygdala, red nucleus, substantia nigra, globus pallidus, putamen, corpus callosum, and thalamus from MRI...
  12. STRUCTURE AND CONNECTIONS OF RED NUCLEUS
    Philip Kennedy; Fiscal Year: 1991
    The aim of this proposal is to understand the structure and connectivity of rat red nucleus. This study will form the basis of a functional study to follow later...
  13. CHEMOKINE RECEPTOR EXPRESSION IN THE CNS
    Jeffrey Harrison; Fiscal Year: 2003
    ..2. evaluate the microglial response and extent of neuronal regeneration in the adult FMN and red nucleus, after nerve transection (facial nerve axotomy or rubrospinal tractotomy, respectively), in mice deficient in ..
  14. SENSORIMOTOR INTEGRATION IN RED NUCLEUS NEURONS
    JAMES HOUK; Fiscal Year: 2000
    ..the proposed studies is to understand the cellular neural events that underlie sensorimotor integration in the red nucleus. Extracellular recordings from red nucleus cells in intact animals have revealed distinct sensory and motor ..
  15. PATTERN FORMATION IN CHICK MIDBRAIN DEVELOPMENT
    CLIFTON RAGSDALE; Fiscal Year: 2005
    ..we established that the most medial arc gives rise to two nuclear structures, the oculomotor complex and the red nucleus. We also demonstrated that a complete set of midbrain arcs could be elicited by an ectopic source of the ..
  16. Global spinal cord trophic factor delivery using intracerebral rAAV in ALS rats
    Ronald Mandel; Fiscal Year: 2007
    ..hypothesis of the present proposal is that either the pyramidal cells of the motor cortex or the neurons in the red nucleus can be permanently transduced by recombinant adeno-associated viral vectors (rAAV) to produce GDNF and IGF1 and ..
  17. Function of Magnocellular Red Nucleus in Reach-to-grasp
    PETER VAN KAN; Fiscal Year: 2006
    ..The focus of the current proposal concerns the functional role of the primate magnocellular red nucleus (RNm) in sensorimotor integration...
  18. NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR
    Joyce Keifer; Fiscal Year: 2009
    ..For research focused on the changes to neural function induced by chronic social stress during adolescence, and to direct pharmacotherapy of associated psychiatric disorders. ..
  19. Susceptibility Weighted Imaging (SWI)
    EWART MARK HAACKE; Fiscal Year: 2010
    ..Recently, SWI has also become available to the clinical world for every day use and therefore its continued technical development is of paramount importance for the proper diagnosis of these diseases in patients. ..
  20. Evaluation of New Imaging Methodologies at 7T
    EWART HAACKE; Fiscal Year: 2007
    ..Many of the approaches developed and applied on this animal system are expected to have important clinical impact. All of these projects will substantially benefit from the proposed acquisition. [unreadable] [unreadable] [unreadable]..
  21. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2003
    ....
  22. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2001
    ....
  23. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2002
    ....
  24. Microinfusion Pump For Animal Functional Brain Mapping
    DANIEL HOLSCHNEIDER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  25. PET Behavioral Brain Mapping In Freely Moving Animals
    DANIEL HOLSCHNEIDER; Fiscal Year: 2006
    ..Such knowledge may provide the basis of an improved integration of a functional brain anatomy in the context of mental disorders. ..
  26. PALLIDAL PHYSIOLOGY IN HUMAN AND PRIMATE DYSTONIA
    PHILIP STARR; Fiscal Year: 2005
    ..Development of an animal model in a large nonhuman primate will open the possibility for further detailed investigations of basal ganglia physiology in dystonia, beyond those which are possible during human surgery. ..
  27. fMRI Activity During the Visual Control of Force
    DAVID VAILLANCOURT; Fiscal Year: 2004
    ..These findings will have further implications for better understanding the visuomotor control deficits associated with aging, and diseased persons with Parkinson's disease, ataxia, and cerebellar deficits. ..
  28. RECOVERY OF FUNCTION AFTER SPINAL CORD DAMAGE
    Marion Murray; Fiscal Year: 2005
    ..One Project investigates functional changes in sensorimotor cortex and red nucleus after spinal injury, and after application of transplantation strategies developed in two Projects and ..
  29. Neural Mechanisms of Inhibitory Classical Conditioning
    John Freeman; Fiscal Year: 2007
    ..The results of these studies may also lead to a better understanding of the functional pathology associated with various psychiatric disorders that involve deficits in behavioral inhibition. ..
  30. Imaging of Serotonin Transporters in Depression
    RAMIN PARSEY; Fiscal Year: 2005
    ..These goals will be met by a combination of didactic I course work and supervision. ..
  31. Biological Predictors of Response to Antidepressants
    Ramin V Parsey; Fiscal Year: 2010
    ..Our overall goal is to reduce the trial and error associated with finding an effective antidepressant by using data from pre-treatment quantification of 5-HT1A receptors and 5-HTT to guide antidepressant treatment selection. ..
  32. Acupuncture and Low Back Pain during Pregnancy
    Shu Ming Wang; Fiscal Year: 2007
    ..abstract_text> ..
  33. BRAINS Morphology and Image Analysis
    Vincent Magnotta; Fiscal Year: 2009
    ....
  34. SPARING AND EXERCISE TRAINING PROMOTE RECOVERY IN SCI
    Michele Basso; Fiscal Year: 2006
    ..abstract_text> ..
  35. Use Dependent Plasticity of Spinal Inhibition
    NIRANJALA TILLAKARATNE; Fiscal Year: 2006
    ..This work will lead to better ways of testing the effectiveness of alternative training strategies and associated pharmacological interventions. ..