raphe nuclei

Summary

Summary: Collections of small neurons centrally scattered among many fibers from the level of the trochlear nucleus in the midbrain to the hypoglossal area in the medulla oblongata.

Top Publications

  1. pmc Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus
    Kae Nakamura
    Laboratory of Sensorimotor Research, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 28:5331-43. 2008
  2. ncbi A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei
    Vera Kiyasova
    INSERM, UMR S 839, Universite Pierre et Marie Curie, and Institut du Fer à Moulin, 75005 Paris, France
    J Neurosci 31:2756-68. 2011
  3. ncbi Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain
    Wenyu Fu
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    J Comp Neurol 518:3464-94. 2010
  4. ncbi Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: Involvement of serotonin-1A, GABA(A), and glutamate receptors
    P Celada
    Department of Neurochemistry, , , 08036 Barcelona, Spain
    J Neurosci 21:9917-29. 2001
  5. pmc 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants
    Jesse W Richardson-Jones
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    Neuron 65:40-52. 2010
  6. ncbi Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor
    Steven F Maier
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Neurosci Biobehav Rev 29:829-41. 2005
  7. ncbi Prefrontal cortical projections to the rat dorsal raphe nucleus: ultrastructural features and associations with serotonin and gamma-aminobutyric acid neurons
    Michael P Jankowski
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260, USA
    J Comp Neurol 468:518-29. 2004
  8. ncbi Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events
    Sachin P Ranade
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    J Neurophysiol 102:3026-37. 2009
  9. pmc Pet-1 is required across different stages of life to regulate serotonergic function
    Chen Liu
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
    Nat Neurosci 13:1190-8. 2010
  10. ncbi Vesicular glutamate transporter 3-expressing nonserotonergic projection neurons constitute a subregion in the rat midbrain raphe nuclei
    Hiroyuki Hioki
    Department of Morphological Brain Science, Kyoto University, Japan
    J Comp Neurol 518:668-86. 2010

Detail Information

Publications289 found, 100 shown here

  1. pmc Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus
    Kae Nakamura
    Laboratory of Sensorimotor Research, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 28:5331-43. 2008
    ..These results suggest that the DRN, probably including serotonin neurons, signals the reward value associated with the current behavior...
  2. ncbi A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei
    Vera Kiyasova
    INSERM, UMR S 839, Universite Pierre et Marie Curie, and Institut du Fer à Moulin, 75005 Paris, France
    J Neurosci 31:2756-68. 2011
    ..factor Pet1 is required for the acquisition of serotonergic identity in a majority of neurons in the raphe nuclei. Nevertheless, a subset of 5-HT neurons differentiates in Pet1 knock-out mice...
  3. ncbi Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain
    Wenyu Fu
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    J Comp Neurol 518:3464-94. 2010
    ..Thus, extrapolation of DRN physiology, and possibly pathology, from rat to mouse, and even human, should be made with caution...
  4. ncbi Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: Involvement of serotonin-1A, GABA(A), and glutamate receptors
    P Celada
    Department of Neurochemistry, , , 08036 Barcelona, Spain
    J Neurosci 21:9917-29. 2001
    ..Afferents from the mPFC also inhibit 5-HT neurons through the activation of GABAergic interneurons. Ascending serotonergic pathways may control the activity of this descending pathway by acting on postsynaptic 5-HT(1A) receptors...
  5. pmc 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants
    Jesse W Richardson-Jones
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    Neuron 65:40-52. 2010
    ..Here we develop a new strategy to manipulate 5-HT(1A) autoreceptors in raphe nuclei without affecting 5-HT(1A) heteroreceptors, generating mice with higher (1A-High) or lower (1A-Low) ..
  6. ncbi Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor
    Steven F Maier
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Neurosci Biobehav Rev 29:829-41. 2005
    ..Finally, implications for the general role of corticotropin-releasing hormone in stress-related phenomena and for the learned helplessness paradigm as an animal model of either depression or anxiety are discussed...
  7. ncbi Prefrontal cortical projections to the rat dorsal raphe nucleus: ultrastructural features and associations with serotonin and gamma-aminobutyric acid neurons
    Michael P Jankowski
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260, USA
    J Comp Neurol 468:518-29. 2004
    ..These results provide potential anatomical substrates whereby the PFC can both directly and indirectly regulate the activity of serotonin neurons in the DRN and possibly contribute to the pathophysiology of depression...
  8. ncbi Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events
    Sachin P Ranade
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    J Neurophysiol 102:3026-37. 2009
    ....
  9. pmc Pet-1 is required across different stages of life to regulate serotonergic function
    Chen Liu
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
    Nat Neurosci 13:1190-8. 2010
    ..These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription...
  10. ncbi Vesicular glutamate transporter 3-expressing nonserotonergic projection neurons constitute a subregion in the rat midbrain raphe nuclei
    Hiroyuki Hioki
    Department of Morphological Brain Science, Kyoto University, Japan
    J Comp Neurol 518:668-86. 2010
    ..cells displayed immunoreactivity for serotonin, but the others were negative in the rat midbrain raphe nuclei, such as the dorsal (DR) and median raphe nuclei (MnR)...
  11. ncbi Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor
    R E Grahn
    Department of Psychology, Behavioral Neuroscience Program, University of Colorado, Boulder, CO 80309, USA
    Brain Res 826:35-43. 1999
    ..Inescapable tailshock led to greater serotonergic neural activity than did escapable tailshock, supporting the hypothesis that uncontrollable stressors preferentially activate serotonergic neurons in the DRN...
  12. ncbi Engrailed genes control developmental fate of serotonergic and noradrenergic neurons in mid- and hindbrain in a gene dose-dependent manner
    Horst H Simon
    Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, 69120 Heidelberg, Germany
    Mol Cell Neurosci 28:96-105. 2005
    ..An almost identical phenotype is found in mutant mice null for Wnt1, indicating that the engrailed genes provide essential positional information for the development of the two nuclei during early embryogenesis...
  13. pmc Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal raphe nucleus: electrophysiological and immunohistochemical studies
    L G Kirby
    Department of Pediatrics, Joseph Stokes Jr Research Institute, Abramson Research Center, 4th Floor North, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    Neuroscience 116:669-83. 2003
    ..In addition, these results present electrophysiological and anatomical evidence for the presence of 5-HT(1A) receptors on non-5-HT neurons in the dorsal raphe nucleus...
  14. ncbi [¹⁸F]FDOPA uptake in the raphe nuclei complex reflects serotonin transporter availability. A combined [¹⁸F]FDOPA and [¹¹C]DASB PET study in Parkinson's disease
    N Pavese
    Centre for Neuroscience, Department of Medicine, Imperial College, London, UK
    Neuroimage 59:1080-4. 2012
    ..18)F]FDOPA uptake in the median raphe nuclei complex of PD patients was significantly correlated with SERT availability in the same structure...
  15. ncbi Recovery of hindlimb motor functions after spinal cord transection is enhanced by grafts of the embryonic raphe nuclei
    U Sławińska
    Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw
    Exp Brain Res 132:27-38. 2000
    ..These results confirm that grafted embryonic raphe nuclei which contain serotoninergic cells are likely to increase the excitability of neuronal circuitry in the injured ..
  16. ncbi Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus
    J Amat
    Department of Psychology, Campus Box 345, University of Colorado, Boulder, Colorado 80903 0345, USA
    Nat Neurosci 8:365-71. 2005
    ..This suggests a new function for the mPFCv and implies that the presence of control inhibits stress-induced neural activity in brainstem nuclei, in contrast to the prevalent view that such activity is induced by a lack of control...
  17. pmc Glutamatergic drive of the dorsal raphe nucleus
    Mariano Soiza-Reilly
    Department of Anesthesiology, Perioperative and Pain Medicine, Children s Hospital, Boston, United States
    J Chem Neuroanat 41:247-55. 2011
    ..Understanding the intricacies of these local networks and their checks and balances, may help identify how potential imbalances could cause psychopathology and illuminate strategies for therapeutic manipulation...
  18. pmc Y-like retinal ganglion cells innervate the dorsal raphe nucleus in the Mongolian gerbil (Meriones unguiculatus)
    Liju Luan
    Department of Anatomy, School of Basic Medical Sciences, Peking University, Beijing, China
    PLoS ONE 6:e18938. 2011
    ..However little is known regarding the type of retinal ganglion cell (RGC) that innervates the DRN. We examined morphological characteristics and physiological properties of these DRN projecting ganglion cells...
  19. pmc Locally collateralizing glutamate neurons in the dorsal raphe nucleus responsive to substance P contain vesicular glutamate transporter 3 (VGLUT3)
    K G Commons
    Department of Anesthesiology, Perioperative, and Pain Medicine, Children s Hospital, Boston, MA, United States
    J Chem Neuroanat 38:273-81. 2009
    ..Taken together, these findings indicate locally collateralizing glutamate neurons responsive to substance P contain VGLUT3...
  20. pmc Forebrain GABAergic projections from the dorsal raphe nucleus identified by using GAD67-GFP knock-in mice
    Sun Jung Bang
    Department of Anesthesiology, Perioperative, and Pain Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Comp Neurol 520:4157-67. 2012
    ..J. Comp. Neurol. 520:4157-4167, 2012. © 2012 Wiley Periodicals, Inc...
  21. pmc Median and dorsal raphe neurons are not electrophysiologically identical
    Sheryl G Beck
    Department of Pediatrics, Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    J Neurophysiol 91:994-1005. 2004
    ....
  22. ncbi Inescapable shock activates serotonergic neurons in all raphe nuclei of rat
    Luiz F Takase
    Departmento de Anatomia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo SP, Brazil
    Behav Brain Res 153:233-9. 2004
    ..This stimulus exerted a consistent and strong activation of the entire midline brain stem system of serotonergic neurons. The implications of these findings for animal models of human psychopathology are discussed...
  23. pmc Activation of the central serotonergic system in response to delayed but not omitted rewards
    Kayoko W Miyazaki
    Neural Computation Unit, Okinawa Institute of Science and Technology, Onna, Okinawa, Japan
    Eur J Neurosci 33:153-60. 2011
    ..There was no reciprocal relationship between serotonin and dopamine. This is the first direct evidence that activation of the serotonergic system occurs specifically in relation to waiting for a delayed reward...
  24. ncbi Projections of the median raphe nucleus in the rat
    R P Vertes
    Center for Complex Systems, Florida Atlantic University, Boca Raton 33431, USA
    J Comp Neurol 407:555-82. 1999
    ..MR fibers distribute densely to the following brainstem/forebrain sites: caudal raphe nuclei, laterodorsal tegmental nucleus, dorsal raphe nucleus, interpeduncular nucleus, medial mammillary body, ..
  25. ncbi Anatomic and functional topography of the dorsal raphe nucleus
    Jolane K Abrams
    University Research Centre for Neuroendocrinology, University of Bristol, Marlborough Street, Bristol BS2 8HW, United Kingdom
    Ann N Y Acad Sci 1018:46-57. 2004
    ..several different subtypes of serotonergic neurons with unique behavioral correlates exist within the brainstem raphe nuclei, raising the possibility that topographically organized subpopulations of serotonergic neurons may have unique ..
  26. ncbi Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline)
    Ritchie E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Neurosci 22:8850-9. 2002
    ..43 and 1, respectively)...
  27. ncbi Differential projections of dorsal raphe nucleus neurons to the lateral septum and striatum
    Maria Waselus
    Department of Neurosurgery, Thomas Jefferson University, Farber Institute for Neurosciences, 900 Walnut Street, Philadelphia, PA 19107, USA
    J Chem Neuroanat 31:233-42. 2006
    ..Taken together with previous microdialysis studies, these results support the existence of distinct DRN-5-HT-forebrain projections that are differentially regulated by stress...
  28. ncbi Identification of the cannabinoid receptor type 1 in serotonergic cells of raphe nuclei in mice
    M Haring
    Department of Physiological Chemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
    Neuroscience 146:1212-9. 2007
    ..this study, we show by in situ hybridization that a low but significant fraction of serotonergic neurons in the raphe nuclei of mice contains CB1 mRNA as illustrated by the coexpression with the serotonergic marker gene tryptophane ..
  29. ncbi Activation of dorsal raphe serotonin neurons underlies waiting for delayed rewards
    Katsuhiko Miyazaki
    Neural Computation Unit, Okinawa Institute of Science and Technology, Okinawa 904 0412, Japan
    J Neurosci 31:469-79. 2011
    ..These results suggest that increased serotonin neuron firing facilitates a rat's waiting behavior in prospect of forthcoming rewards and that higher serotonin activation enables longer waiting...
  30. ncbi Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo
    K A Allers
    University Department of Pharmacology, Mansfield Road, Oxford, UK OX1 3QT
    Neuroscience 122:193-204. 2003
    ..The electrophysiological and morphological properties of these neurones suggest a novel function involving co-ordination between GABA and 5-HT neurones dispersed across DRN subregions...
  31. ncbi Serotonin and the regulation of mammalian circadian rhythmicity
    L P Morin
    Department of Psychiatry, Health Sciences Center, State University of New York, Stony Brook 11794, USA
    Ann Med 31:12-33. 1999
    ..The next decade is likely to see the gradual evolution of this framework as the role of serotonin in circadian rhythm regulation is further elucidated...
  32. ncbi Early life experience alters behavior during social defeat: focus on serotonergic systems
    K L Gardner
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    Neuroscience 136:181-91. 2005
    ....
  33. ncbi Modulation of the activity of pyramidal neurons in rat prefrontal cortex by raphe stimulation in vivo: involvement of serotonin and GABA
    M Victoria Puig
    Department of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona CSIC, IDIBAPS, 08036 Barcelona, Spain
    Cereb Cortex 15:1-14. 2005
    ..g. major depression, schizophrenia). We examined the effect of the stimulation of the dorsal and median raphe nuclei (DR and MnR, respectively) on the activity of PFC neurons...
  34. ncbi Influence of inhibitory and excitatory inputs on serotonin efflux differs in the dorsal and median raphe nuclei
    Rui Tao
    Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Brain Res 961:109-20. 2003
    The dorsal (DRN) and median raphe nuclei (MRN) are two major sources of serotonergic projections to forebrain that are involved in regulation of behavioral state and motor activity, and implicated in affective disorders such as depression ..
  35. ncbi Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex
    Mercè Amargós-Bosch
    Department of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona CSIC, IDIBAPS, Barcelona, Spain
    Cereb Cortex 14:281-99. 2004
    ..The electrical stimulation of the dorsal and median raphe nuclei elicited 5-HT1A-mediated inhibitions and 5-HT2A-mediated excitations in identified pyramidal neurons recorded ..
  36. ncbi Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide
    Sylvie Lemonde
    Ottawa Health Research Institute Neuroscience, University of Ottawa, Department of Medicine, Ottawa, Canada, K1H 8M5
    J Neurosci 23:8788-99. 2003
    ..receptors in serotonergic raphe cells, hippocampal and cortical neurons, and adult brain regions including raphe nuclei, indicating a role in regulating 5-HT1A autoreceptor expression...
  37. ncbi Morphological features and electrophysiological properties of serotonergic and non-serotonergic projection neurons in the dorsal raphe nucleus. An intracellular recording and labeling study in rat brain slices
    Y Q Li
    Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, 710032, People's Republic of, Xi'an, China
    Brain Res 900:110-8. 2001
    ..Some other differences in electrophysiological properties were also observed between the 5-HT-immunoreactive spiny projection neurons and the 5-HT-immunonegative aspiny projection neurons...
  38. ncbi Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress
    Sayamwong E Hammack
    Department of Psychiatry, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA 30322, USA
    Behav Brain Res 147:55-64. 2003
    ..In a separate experiment, the effective dose of CRH blocked the usual behavioral consequences of uncontrollable stress...
  39. ncbi State-dependent effects of orexins on the serotonergic dorsal raphe neurons in the rat
    Kazumi Takahashi
    Department of Physiology, Fukushima Medical University School of Medicine, 1 Hikari ga oka, Fukushima 960 1295, Japan
    Regul Pept 126:43-7. 2005
    ..These results suggest that orexinergic neurons exert excitatory influence on the serotonergic DR neurons to maintain tonic activity of them, thereby participating in regulation of sleep-wakefulness cycles and other functions...
  40. pmc Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs
    M F Wu
    Department Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Physiol 554:202-15. 2004
    ....
  41. ncbi Cellular basis for the effects of substance P in the periaqueductal gray and dorsal raphe nucleus
    Kathryn G Commons
    Children s Hospital of Philadelphia, Joseph Stokes Research Institute, 402 Abramson Research Center, Philadelphia, Pennsylvania 19104, USA
    J Comp Neurol 447:82-97. 2002
    ..This circuitry could contribute to, as well as coordinate, effects of SP on pain perception and mood...
  42. ncbi The role of corticotropin-releasing hormone in the dorsal raphe nucleus in mediating the behavioral consequences of uncontrollable stress
    Sayamwong E Hammack
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309 0345, USA
    J Neurosci 22:1020-6. 2002
    ..The potential role of the caudal DRN in states of anxiety is discussed...
  43. ncbi Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal firing of the midbrain raphe nuclei 5-HT neurons and a decrease of their response to 5-HT(1A) receptor stimulation in the rat
    S Wang
    Department of Physiology and Pathophysiology, School of Medicine, Xi an Jiaotong University, Xi an 710061, Shaanxi, China
    Neuroscience 159:850-61. 2009
    ..In the present study, we examined the changes in the firing rate and firing pattern of the dorsal and median raphe nuclei (DRN and MRN) 5-HT neurons, and the effect of the selective 5-HT(1A) receptor agonist (R)-(+)-8-hydroxy-2-(..
  44. ncbi Sleep-waking discharge profiles of dorsal raphe nucleus neurons in mice
    K Sakai
    INSERM U1028, CNRS UMR5292, Neuroscience Research Center, University Lyon 1, Integrative Physiology of Brain Arousal System, F 69373, Lyon, France
    Neuroscience 197:200-24. 2011
    ....
  45. ncbi Role of serotonin transporter inhibition in the regulation of tryptophan hydroxylase in brainstem raphe nuclei: time course and regional specificity
    L MacGillivray
    Department of Medicine Neurology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    Neuroscience 171:407-20. 2010
    ..We studied the time course of changes in tryptophan hydroxylase (TPH) in four raphe nuclei after initiation of two different SERT inhibitors, citalopram and fluoxetine...
  46. ncbi Functional topography of midbrain and pontine serotonergic systems: implications for synaptic regulation of serotonergic circuits
    Matthew W Hale
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Psychopharmacology (Berl) 213:243-64. 2011
    ..Recent studies suggest that there is anatomical and functional diversity among serotonergic systems innervating forebrain systems involved in the control of physiologic and behavioral responses, including the control of emotional states...
  47. ncbi Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF)
    T R Madhav
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res Mol Brain Res 93:56-63. 2001
    ..the high-affinity receptor for brain-derived neurotrophic factor (BDNF) amongst serotonergic cell bodies of the raphe nuclei and their ascending projections into the dorsal hippocampus in the rat brain...
  48. ncbi Distinct neurochemical and functional properties of GAD67-containing 5-HT neurons in the rat dorsal raphe nucleus
    Hiroki Shikanai
    Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 32:14415-26. 2012
    ..These findings indicate that 5-HT/GAD67 neurons constitute a unique neuronal population with distinctive neurochemical and electrophysiological properties and high responsiveness to innocuous stressor...
  49. ncbi Circadian clock resetting by behavioral arousal: neural correlates in the midbrain raphe nuclei and locus coeruleus
    I C Webb
    Department of Psychology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
    Neuroscience 166:739-51. 2010
    ..The dorsal and median raphe nuclei (DRN, MnR) have been implicated in clock resetting by arousal and, in rats and mice, exhibit strong regionally ..
  50. ncbi Differentiation of presumed serotonergic dorsal raphe neurons in relation to behavior and wake-sleep states
    K Sakai
    INSERM U480, Department of Experimental Medicine, Claude Bernard University, Lyon 1, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Neuroscience 104:1141-55. 2001
    ..From these data we suggest that presumed serotonergic dorsal raphe neurons play different roles in behavioral state control and that there is functional topographic organization in the dorsal raphe nucleus...
  51. ncbi Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs
    J K Abrams
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    Neuroscience 133:983-97. 2005
    ....
  52. ncbi Patterns of fos activation in rat raphe nuclei during feeding behavior
    Luiz Fernando Takase
    Laboratory of Neurosciences, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Brain Res 1200:10-8. 2008
    To analyze the differential recruitment of the raphe nuclei during different phases of feeding behavior, rats were subjected to a food restriction schedule (food for 2 h/day, during 15 days)...
  53. ncbi Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous
    Silvia Marinelli
    Pain Management Research Institute, Northern Clinical School, University of Sydney, New South Wales, 2006 Australia
    J Neurophysiol 92:3532-7. 2004
    ..The findings also suggest that the activity of the different populations of DRN neurons will display heterogeneous changes when the serotonergic tone in the DRN is altered by neurological disorders or by drug treatment...
  54. ncbi Evidence for serotonin synthesis-dependent regulation of in vitro neuronal firing rates in the midbrain raphe complex
    Andrew K Evans
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Bristol BS1 3NY, United Kingdom
    Eur J Pharmacol 590:136-49. 2008
    ..These studies support the hypothesis that tonic autoregulation of serotonergic neuronal firing rates is dependent on tryptophan availability and characterise conditions necessary to study this process in vitro...
  55. ncbi 5,7-DHT lesion of the dorsal raphe nuclei impairs object recognition but not affective behavior and corticosterone response to stressor in the rat
    Cindy K J Lieben
    Department of Psychiatry and Neuropsychology Basal Neuroscience, University of Maastricht, Maastricht, The Netherlands
    Behav Brain Res 168:197-207. 2006
    ..The 5,7-DHT treatment did not affect the corticosterone response to a stressful situation. Overall, these results corroborate studies with acute tryptophan depletion suggesting a role of 5-HT in object memory, but not affective behavior...
  56. ncbi Altered regulation of the 5-HT system in the brain of MAO-A knock-out mice
    A Evrard
    INSERM U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Eur J Neurosci 15:841-51. 2002
    ....
  57. ncbi Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims
    V Arango
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 25:892-903. 2001
    ..Less feedback inhibition of serotonin DRN firing via 5-HT(1A) autoreceptors and enhancement of serotonin action due to less uptake of serotonin, is consistent with compensatory changes in response to hypofunction in depressed suicides...
  58. ncbi Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1127-32. 2008
    ..The findings confirm the exclusive specificity of Tph2 in brain 5-HT synthesis and suggest that Tph2-synthesized 5-HT is not required for serotonergic neuron formation...
  59. ncbi More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides
    Maura Boldrini
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Brain Res 1041:19-28. 2005
    ..We sought to determine the amount of TPH immunoreactivity (TPH-IR) in the dorsal (DRN) and median (MRN) raphe nuclei in suicides and controls...
  60. ncbi Midbrain raphe modulation of nonphotic circadian clock resetting and 5-HT release in the mammalian suprachiasmatic nucleus
    J David Glass
    Department of Biological Sciences, Kent State University, Kent, Ohio 44242 0001, USA
    J Neurosci 23:7451-60. 2003
    ..These results indicate that 5-HT7 and GABAergic receptors of the DRN and MRN regulate behaviorally induced 5-HT release in the SCN, and that DRN output modulates nonphotic phase-resetting responses...
  61. ncbi Cellular mechanism for anti-analgesic action of agonists of the kappa-opioid receptor
    Z Z Pan
    Department of Neurology, University of California, San Francisco 94143, USA
    Nature 389:382-5. 1997
    ..Our findings suggest a new cellular mechanism for the potentially ubiquitous opposing interaction between mu- and kappa-opioid receptors and may help in the design of treatments for pain...
  62. ncbi Sensorimotor-related discharge of simultaneously recorded, single neurons in the dorsal raphe nucleus of the awake, unrestrained rat
    Barry D Waterhouse
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Brain Res 1000:183-91. 2004
    ....
  63. ncbi Phasic responses in dorsal raphe serotonin neurons to noxious stimuli
    J V Schweimer
    Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Neuroscience 171:1209-15. 2010
    ..These results suggest that discrete groups of serotonin neurons differentially code for aversive stimuli...
  64. ncbi Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635
    Z Bhagwagar
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Mol Psychiatry 9:386-92. 2004
    ..In contrast, 5-HT(1A) BP in the raphe nuclei did not distinguish depressed subjects from controls...
  65. ncbi Projections from the raphe nuclei to the suprachiasmatic nucleus of the rat
    Anders Hay-Schmidt
    Department of Medical Anatomy, The Panum Institute, 18 2, University of Copenhagen, Blegdamsvej 3, DK 2200 N, Copenhagen, Denmark
    J Chem Neuroanat 25:293-310. 2003
    ..was centred in the rat SCN, and a few retrograde labelled neurones were distributed in the dorsal and median raphe nuclei (MnR) and in the rostral part of the raphe magnus (RMg), but no neurones were found in the raphe pallidus or ..
  66. pmc Coding of task reward value in the dorsal raphe nucleus
    Ethan S Bromberg-Martin
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:6262-72. 2010
    ..A smaller component of neural activity reflected detection of reward delivery. Our data suggest that the dorsal raphe nucleus encodes participation in a behavioral task in terms of its future motivational outcomes...
  67. ncbi The dorsal raphe nucleus--from silver stainings to a role in depression
    Kimmo A Michelsen
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Brain Res Rev 55:329-42. 2007
    ..Starting with a historical perspective, this essay describes the morphology, ascending projections and multitransmitter nature of the DRN, and stresses its role as a key target for depression research...
  68. ncbi The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress
    J Amat
    Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
    Brain Res 917:118-26. 2001
    ..These results suggest that the habenula is necessary for the differential activation of the DRN and the escape deficits produced by IS...
  69. ncbi In vivo inhibition of neuronal activity in the rat ventromedial prefrontal cortex by midbrain-raphe nuclei: role of 5-HT1A receptors
    Mihaly Hajos
    Neurobiology, Pharmacia Corporation, 301 Henrietta Street, Kalamazoo, MI 49007, USA
    Neuropharmacology 45:72-81. 2003
    ..the electrophysiological response of ventral mPFC neurones to electrical stimulation of the dorsal and median raphe nuclei (DRN and MRN), which are the source of the 5-HT input...
  70. ncbi Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs)
    Nicolas Narboux-Nême
    INSERM, UMR S 839, Paris, France
    Neuropharmacology 55:994-1005. 2008
    ..The identification of targets of SSRIs and serotonin releasers during embryonic and early postnatal life helps understanding the very diverse physiological consequences of administration of these drugs during development...
  71. ncbi Serotonin-related enhancement of recovery of hind limb motor functions in spinal rats after grafting of embryonic raphe nuclei
    Henryk Majczynski
    Nencki Institute of Experimental Biology, Interinstitute Laboratory of Neuromuscular Plasticity, Polish Academy of Sciences, Warsaw, Poland
    J Neurotrauma 22:590-604. 2005
    Recently, we demonstrated improvements in hind limb locomotor-like movements following grafting of embryonic raphe nuclei cells into the spinal cord below the level of total transection in adult rats...
  72. ncbi Retinal afferents to the dorsal raphe nucleus in rats and Mongolian gerbils
    K V Fite
    Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Comp Neurol 414:469-84. 1999
    ..Major differences observed in the extent and configuration of the retinal-DRN pathway may be related to the diurnal/crepuscular vs. nocturnal habits of these two species...
  73. ncbi Topographic organization and neurochemical identity of dorsal raphe neurons that project to the trigeminal somatosensory pathway in the rat
    M L Kirifides
    Department of Neurobiology and Anatomy, MCP-Hahnemann University, Philadelphia, Pennsylvania 19129, USA
    J Comp Neurol 435:325-40. 2001
    ..Taken together, these findings provide further evidence of neurochemical specificity and functional anatomical organization within the DR efferent projection system...
  74. pmc Role of the medial prefrontal cortex in 5-HT1A receptor-induced inhibition of 5-HT neuronal activity in the rat
    M Hajos
    Oxford University Department of Clinical Pharmacology, Radcliffe Infirmary
    Br J Pharmacol 126:1741-50. 1999
    ....
  75. ncbi Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide
    Helene Bach-Mizrachi
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 31:814-24. 2006
    ..Higher TPH2 mRNA expression may explain more TPH protein observed in depressed suicides and reflect a homeostatic response to deficient brain serotonergic transmission...
  76. ncbi Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression
    Michelle Hendricksen
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Am J Psychiatry 161:1096-102. 2004
    ..hypothesized that greater neurofibrillary pathology and fewer serotonergic neurons would be found in the dorsal raphe nuclei in depressed elderly subjects, compared with nondepressed elderly subjects, and in Alzheimer's disease patients ..
  77. ncbi Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences
    Q Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health Clinical Center, Bethesda, Maryland 20892 1264, USA
    J Neurosci 20:7888-95. 2000
    ..Finally, alterations in G-protein coupling to 5-HT(1A) receptors are unlikely to be involved in the desensitization of 5-HT(1A) receptors in 5-HTT -/- mice...
  78. ncbi GAP-43 is critical for normal development of the serotonergic innervation in forebrain
    Stacy L Donovan
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Neurosci 22:3543-52. 2002
    Serotonergic (5-HT) axons from the raphe nuclei are among the earliest afferents to innervate the developing forebrain...
  79. pmc Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei
    N Donner
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80526, USA
    Neuroscience 163:705-18. 2009
    Dysfunctions of the brain 5-HT system are often associated with affective disorders, such as depression. The raphe nuclei target the limbic system and most forebrain areas and constitute the main source of 5-HT in the brain...
  80. ncbi Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition
    Enrica Audero
    Mouse Biology Unit, European Molecular Biology Laboratory EMBL, Via Ramarini 32, 00015 Monterotondo, Italy
    Science 321:130-3. 2008
    ..These findings show that excessive serotonin autoinhibition is a risk factor for catastrophic autonomic dysregulation and provide a mechanism for a role of altered serotonin homeostasis in sudden infant death syndrome...
  81. pmc Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides
    H Bach-Mizrachi
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA
    Mol Psychiatry 13:507-13, 465. 2008
    ..and computer-assisted image analysis were performed on tissue sections throughout the extent of the raphe nuclei at the level of silver grains per neuron to systematically quantify TPH2 neuronal expression...
  82. ncbi The circadian visual system, 2005
    L P Morin
    Department of Psychiatry and Graduate Program in Neuroscience, Stony Brook University, Stony Brook, NY 11794, USA
    Brain Res Rev 51:1-60. 2006
    ..The present discussion is an extension of the material covered by the 1994 review, "The Circadian Visual System."..
  83. ncbi Diurnal variation of c-Fos expression in subdivisions of the dorsal raphe nucleus of the Mongolian gerbil (Meriones unguiculatus)
    S Janusonis
    Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Comp Neurol 440:31-42. 2001
    ..These results suggest that DRN subdivisions may differ functionally with regard to the diurnal cycle, and that these differences may be reflected in the activity of nonserotonergic cells in the DRN...
  84. ncbi Prefrontal afferents to the dorsal raphe nucleus in the rat
    Luciano Gonçalves
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Sao Paulo, Brazil
    Brain Res Bull 78:240-7. 2009
    ..Overall, these results confirm the existence of robust prefrontal projections to DR, mainly derived from the ventral part of the medial PFC, and underscore a substantial contribution of the frontal polar cortex...
  85. ncbi Circumscribed numerical deficit of dorsal raphe neurons in mood disorders
    B Baumann
    Department of Psychiatry, University, of Magdeburg, Germany
    Psychol Med 32:93-103. 2002
    ..Although serotonergic systems appear to be involved in the pathology of mood disorders, there is uncertainty as to whether structural alterations in raphe nuclei exist alongside a functional dysregulation of the serotonergic system.
  86. ncbi The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep
    Jaime M Monti
    Department of Pharmacology and Therapeutics, School of Medicine Clinics Hospital, Montevideo, Uruguay
    Sleep Med Rev 14:319-27. 2010
    ..Presently, there are no data on the effect of local infusion into the DRN of noradrenergic, dopaminergic, histaminergic, orexinergic and cholinergic agonists on sleep variables in laboratory animals...
  87. pmc Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
    Proc Natl Acad Sci U S A 104:17087-92. 2007
    ..More generally, the powerful interaction between the STN and 5-HT system uncovered here offers insights into the high level of comorbidity of basal ganglia disease and mood disorder...
  88. ncbi Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test
    J A Clark
    Merck Research Laboratories, Rahway, NJ, USA
    Neuropharmacology 63:1051-63. 2012
    ....
  89. ncbi Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei
    Albert Adell
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Carrer Rosselló 161, 6th Floor, E 08036 Barcelona, Spain
    Brain Res Brain Res Rev 39:154-80. 2002
    ..of the extracellular compartment of the transmitter serotonin (5-hydroxytryptamine, 5-HT) in the midbrain raphe nuclei because it can control the activity of ascending serotonergic systems and the release of 5-HT in terminal areas ..
  90. ncbi Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons
    Benjamin N Greenwood
    Department of Kinesiology and Applied Physiology, Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    J Neurosci 23:2889-98. 2003
    ..An increase in 5-HT1A inhibitory autoreceptor expression may contribute to the attenuation of DRN 5-HT activity and the prevention of LH in physically active rats...
  91. ncbi Nitric oxide modulates N-methyl-D-aspartate-evoked serotonin release in the raphe nuclei and frontal cortex of the freely moving rat
    J C Smith
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, WC1N 1AX, London, UK
    Neurosci Lett 291:5-8. 2000
    ..NO) in N-methyl-D-aspartate (NMDA)-regulated release of 5-hydroxytryptamine (5-HT) in the frontal cortex and raphe nuclei of freely moving rats has been studied using microdialysis with dual probes, one in each region of the same ..
  92. ncbi Functional mapping of the cardiorespiratory effects of dorsal and median raphe nuclei in the rat
    R M Alvarenga
    Programa de Pós Graduação em Ciências Fisiológicas, Centro Biomedico, Universidade Federal do Espirito Santo, Vitoria, ES, Brazil
    Braz J Med Biol Res 38:1719-27. 2005
    The dorsal (DRN) and median (MRN) raphe nuclei are important sources of serotonergic innervation to the forebrain, projecting to sites involved in cardiovascular regulation...
  93. ncbi Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists
    Guillaume Lucas
    Departement de Psychiatrie, Universite McGill, Montreal, Quebec, Canada
    Biol Psychiatry 57:918-25. 2005
    ..In addition, the poor distribution of 5-HT4 receptors within the DRN raised the question of the neuroanatomical bases underlying this control...
  94. pmc Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice
    J A Clark
    Stroke and Neurodegeneration, Merck Research Laboratories, West Point, PA 19486, USA
    Mol Psychiatry 13:498-506. 2008
    ..TPH2 immunoreactivity (IR) was detected throughout the raphe nuclei, in lateral hypothalamic nuclei and in the pineal body of rodent and human brain...
  95. ncbi Wheel running alters serotonin (5-HT) transporter, 5-HT1A, 5-HT1B, and alpha 1b-adrenergic receptor mRNA in the rat raphe nuclei
    Benjamin N Greenwood
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309 0354, USA
    Biol Psychiatry 57:559-68. 2005
    ..In the current study, we investigated whether physical activity alters factors involved in the regulation of central 5-HT neural activity...
  96. ncbi The human raphe nuclei and the serotonergic system
    Jean Pierre Hornung
    Institut de Biologie Cellulaire et de Morphologie, University of Lausanne, Rue du Bugnon 9, 1005, Lausanne, Switzerland
    J Chem Neuroanat 26:331-43. 2003
    The raphe nuclei are distributed near the midline of the brainstem along its entire rostro-caudal extension...
  97. pmc Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression
    Katherine L Gardner
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    Brain Res 1305:47-63. 2009
    ..These data support the hypothesis that early life experience and major stressful life events contribute to dysregulation of serotonergic systems in stress-related neuropsychiatric disorders...
  98. pmc Transcriptional expression of serotonergic regulators in laser-captured microdissected dorsal raphe neurons of subjects with major depressive disorder: sex-specific differences
    Dharmendra B Goswami
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, USA
    J Neurochem 112:397-409. 2010
    ..This study reveals sex-specific alterations in gene expression of the pre-synaptic 5-HT1D autoreceptors and 5-HT-related transcription factors, NUDR and REST, in DR neurons of women with MDD...
  99. ncbi Fos-like immunoreactivity in rat dorsal raphe nuclei induced by alkaloid extract of Mitragyna speciosa
    Ekkasit Kumarnsit
    Department of Physiology, Faculty of Science, Prince of Songkla University, Songkhla Province 90112, Thailand
    Neurosci Lett 416:128-32. 2007
    ..Moreover, the dorsal raphe nucleus may be one of site of MS action in the central nervous system...
  100. pmc Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function
    Francine Cote
    Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs, CNRS, Unité Mixte de Recherche 7091 et Institut Fédératif de Recherche 70, Hopital de la Pitie Salpetriere, Paris, France
    Proc Natl Acad Sci U S A 100:13525-30. 2003
    ..with the beta-galactosidase gene, we establish that the neuronal tph2 is expressed in neurons of the raphe nuclei and of the myenteric plexus, whereas the nonneuronal tph1, as detected by beta-galactosidase expression, is in ..
  101. ncbi 5-ht5B receptor mRNA in the raphe nuclei: coexpression with serotonin transporter
    Jordi Serrats
    Department of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona IIBB CSIC IDIBAPS, Barcelona, Spain
    Synapse 51:102-11. 2004
    ..The degree of cellular colocalization of these mRNAs notably varied among the different regions of the raphe nuclei. In the DR, cell bodies showing 5-ht(5B) receptor mRNA expression were abundant in the medial portions of the ..

Research Grants62

  1. Hiv-1 Infection: Central Serotonergic Activity and its Health Implications
    Adarsh M Kumar; Fiscal Year: 2010
    ..to investigate the central serotonergic activity in the postmortem tissue samples from different brain regions {raphe nuclei, hypothalamus, hippocampus, basal ganglia (caudate nucleus, putamen, globus pallidus), substantia nigra, ..
  2. Anxiety development in 5-HT1A autoreceptor knockout mice, interaction with stress
    Rene Hen; Fiscal Year: 2010
    ..model, the 5-HT1A autoreceptor KO mouse, to determine the critical period for its influence on the serotonergic raphe nuclei in producing anxiety and the potential impact of environmental stress to amplify the genetic effect...
  3. Serotonin, Autism, and investigating cell types for CNS disorders.
    Joseph D Dougherty; Fiscal Year: 2010
    ..test the first approach, we have isolated the complete translational profile of the serotonergic neurons of the raphe nuclei. As dysregulation of the serotonergic system has long been suspected to be involved in autism3, we have tested ..
  4. Developmental defects in serotonin neurons and the response to O2 and CO2
    George B Richerson; Fiscal Year: 2011
    ..We have proposed that serotonin neurons of the raphe nuclei are sensors of arterial carbon dioxide that respond to hypercapnia by inducing arousal, an increase in ..
  5. Functionally Significant Polymorphisms in Serotonin Pathway Genes
    Beverly H Koller; Fiscal Year: 2010
    ..is produced by a two step enzymatic process from the amino acid tryptophan, primarily by neurons located in the raphe nuclei. These neurons project too many regions of the brain including the cortex, thalamus, hypothalamus, and amygdala...
  6. The Neurochemistry of Cognitive Therapy: Predicting Treatment Outcome with PET
    Jeffrey M Miller; Fiscal Year: 2013
    ..of the serotonin 1A (5-HT1A) receptor in two specific brain regions, the orbitofrontal cortex and raphe nuclei, may be predictive of outcome with CBT for depression...
  7. White Matter Lesions and Cortical Serotonergic Deafferentation in Older Adults
    Martijn L T M Muller; Fiscal Year: 2010
    ..Serotonin is widely distributed in the brain with most serotonin producing cell-bodies located in the raphe nuclei of the brainstem...
  8. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David W Carley; Fiscal Year: 2013
    ..Similar targeted manipulations will be conducted in the raphe nuclei, an important source of serotonergic inputs to PPT...
  9. Modulation of Glomerular Function
    MICHAEL THOMAS SHIPLEY; Fiscal Year: 2013
    ..specific neuromodulatory systems - cholinergic inputs from the diagonal band and serotonergic inputs from the raphe nuclei. Our working hypothesis is that ACh and 5HT differentially modulate glomerular processing to shape both pre- ..
  10. BRAINSTEM RESPIRATORY NEURON INTERACTIONS
    Bruce G Lindsey; Fiscal Year: 2010
    ..network that includes multifunctional neurons in the "pontine respiratory group" (PRG), the medullary raphe nuclei, and the locus ceruleus. The project has four specific aims: 1...
  11. Role of the 5-HT1A Receptors in Cocaine Dependence
    Sunmee Wee; Fiscal Year: 2010
    ..Specific Aim 2 investigates time-dependent changes in 5-HT1A receptors in the extended amygdala and raphe nuclei in rats with extended access using Western blot and immunofluorescence...
  12. Cell Lineage-Based Analysis of Connectivity and Modulation in Prefrontal Cortex
    Rodrigo Andrade; Fiscal Year: 2013
    ..the median prefrontal cortex, receives a dense serotonergic innervation originating from the Dorsal and Median Raphe nuclei of the brainstem...
  13. Monitoring Neural Activity in Freely Behaving Zebrafish Larvae with Bioluminescen
    Florian Engert; Fiscal Year: 2013
    ..be targeted to the hypocretin-positive neurons of the hypothalamus, the serotonergic neurons of the raphe nuclei and the dopaminergic neurons of the ventral hypothalamus...
  14. 5 HYDROXTRYPTAMINE MECHANISMS OF HALLUCINOGENIC DRUGS
    DAVID MOKLER; Fiscal Year: 1992
    ..effects of hallucinogenic drugs on 5-HT neurons activated by electrical stimulation of the dorsal and median raphe nuclei. Microdialysis probes will be implanted into medial prefrontal cortex, striatum, nucleus accumbens, hippocampus ..
  15. Time Course and Potentiation of Fluoxetin Action
    George Battaglia; Fiscal Year: 2004
    ..highly regulated by inhibitory 5-HT1A autoreceptors on the soma and dendrites of the serotonergic cells in the raphe nuclei and by inhibitory 5-HT1B/1D autoreceptors on the serotonergic nerve terminals in forebrain regions...
  16. BRAIN REGULATING GASTRIC ACID FUNCTION BY NEUROPEPTIDES
    YVETTE TACHE; Fiscal Year: 2000
    ..aims of this application are (1) to define the roles and regulation of TRH/5-HT projections from caudal raphe nuclei to the DMN in vagally-mediated stimulation of gastric function, particularly as it relates to the gastric ..
  17. Neuroprotective Effects of Estrogen in Serotonin Neurons
    Jessica Henderson; Fiscal Year: 2007
    ..serotonin neurons, determine the effect of estrogen treatment on KMO mRNA and protein expression in the dorsal raphe nuclei, and investigate the effect of estrogen treatment on kynurenic acid/ quinolinic acid ratios in serotonin ..
  18. CANNABINOIDS AND THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    Laura Murphy; Fiscal Year: 2002
    ..in the ability of cannabinoids to affect the HPA axis and by examining the hypothalamus, hippocampus, amygdala, raphe nuclei) as potential sites of cannabinoid action...
  19. Functionally Significant Polymorphisms in Serotonin Pathway Genes
    Beverly Koller; Fiscal Year: 2009
    ..is produced by a two step enzymatic process from the amino acid tryptophan, primarily by neurons located in the raphe nuclei. These neurons project too many regions of the brain including the cortex, thalamus, hypothalamus, and amygdala...
  20. PLASTICITY OF MAMMALIAN CIRCADIAN AXIS
    Gianluca Tosini; Fiscal Year: 2003
    ..Such cell bodies, which are normally found only in the raphe nuclei, appear in large numbers in the SCN of hamsters that have been held for 16-20 weeks in constant darkness...
  21. HYPOTHYROID AND AUTONOMIC CHANGES--ROLE OF MEDULLARY TRH
    Hong Yang; Fiscal Year: 1999
    ..Recent studies revealed that TRH and serotonin (5-HT), synthesized and co-existing in medullary raphe nuclei and innervating spinal sympathetic and medullary vagal preganglionic motoneurons, play important roles in ..
  22. MDMA NEUROTOXICITY IN PRIMATE: PERMANENT OR TRANSIENT?
    George Ricaurte; Fiscal Year: 1993
    ..MDMA-treated monkeys that have sustained severe serotonergic nerve fiber damage, but no cell body loss in the raphe nuclei. Pilot studies indicate that partial recovery of serotonin takes place in these animals over a ten week period...
  23. BRAINSTEM NEURAL NETWORKS AND AIRWAY DEFENSIVE REFLEXES
    Roger Shannon; Fiscal Year: 2002
    ..modulates the BOT/VRG generated cough motor pattern through divergent actions of specific neurons uon the and raphe nuclei. Hypothesis VI. The raphe neuronal network is modulated during cough by inputs from NTS, PRG, and BOT/VRG...
  24. IN VITRO INTERACTIONS BETWEEN CIRCADIAN CLOCK AFFERENTS
    Rebecca Prosser; Fiscal Year: 1999
    ..phase is modulated by afferents from the retina, intergeniculate leaflet of the lateral geniculate nucleus, and raphe nuclei. The primary neurotransmitters for these inputs are an excitatory amino acid (possibly glutamate), neuropeptide ..
  25. SLEEP MECHANISMS IN THE AGED CAT
    Michael Chase; Fiscal Year: 2003
    ..specifically the laterodorsal and pedunculo-pontine tegmental nuclei (LDT/PPT), the locus coeruleus, the dorsal raphe nuclei and the nucleus pontis oralis...
  26. Multiphoton Monoamine Imaging of Serotonin Neuron Function
    EDWIN LEVITAN; Fiscal Year: 2009
    Serotonin neurons of the raphe nuclei control mood and are sensitive to drugs of abuse such as the amphetamine MDMA (3,4-Methylenedioxymethamphetamine, Ecstasy) and cocaine...
  27. ABNORMAL MOVEMENTS AND PHARMACOLOGY OF THE FOREBRAIN
    S Snodgrass; Fiscal Year: 1980
    ..studies focus upon the serotonergic neurons of the forebrain, whose cell bodies lie in the dorsal and median raphe nuclei. Selective chemical lesions will be used to destroy portions of this ascending neuronal system...
  28. Raphe Nuclei Projections to Vestibular Nuclei
    ADAM HALBERSTADT; Fiscal Year: 2005
    The goal of this research project is to characterize the organization of projections from the raphe nuclei to the vestibular system...
  29. SEROTONIN AND HPA AXIS INTERACTIONS IN SUICIDE BRAINS
    Juan Lopez; Fiscal Year: 1999
    ..5HT receptor binding and mRNA levels in the limbic system, hypothalamus and raphe nuclei; 2. glucocorticoid (GR) and mineralocorticoid (MR) receptor mRNA levels in the same regions; 3...
  30. MATERNAL DRUG ABUSE: EFFECTS ON FETAL RAPHE DEVELOPMENT
    GENE JONAKAIT; Fiscal Year: 1992
    ..Since cells of the raphe nuclei in the medulla oblongata, long defined by their use of serotonin (5-hydroxytryptamine; 5-HT) as a ..
  31. NEUROBIOLOGICAL EFFECTS OF ALTERED MOTOR CONTROL IN REM
    LARRY SANFORD; Fiscal Year: 2001
    ..silencing of noradrenergic (NA) and serotonergic (5-HT) neurons in brainstem locus coeruleus (LC) and dorsal raphe nuclei (DRN) as an animal passes from wakefulness (W) to non-rapid-eye movement sleep (NREM) to rapid eye-movement ..
  32. 5-HT1A receptor and hallucinogens
    CHAD REISSIG; Fiscal Year: 2005
    ..by DOM, a phenethylamine hallucinogen, [b] the specific role of 5-HT1A receptors of the dorsal and medial raphe nuclei in DOM induced stimulus control, [c] the role of G protein activation in the interactions of 5-HTIA agonists ..
  33. IL-1 & D5-HT INTERACTIONS--INVOLVEMENT IN SLEEP REGULATI
    Mark Opp; Fiscal Year: 1999
    ..1) Does 5-HT mediate, in part, IL-1-induced alterations in non-rapid eye movement sleep (NREMS)? 2) Do raphe nuclei mediate this effect? 3) Does IL-1 mediate, in part, the enhancement of NREMS induced by the 5-HT precursor L-..
  34. HABENULAR-MESOLIMBIC NEUROCHEMICAL INTERACTIONS
    Samuel Speciale; Fiscal Year: 1980
    ..SP and oxotremorine (a cholinergic agonist) will be injected systemically or directly into VTA or dorsal raphe nuclei to further characterize their influence...
  35. VISCEROSOMATIC INTERACTIONS IN RETICULAR FORMATION
    Robert Blair; Fiscal Year: 1992
    ..Finally, different nuclear groups in the midline raphe nuclei will have functional connections with LRF neurons...
  36. A NEW ETS FACTOR IN THE SEROTONERGIC SYSTEM
    Evan Deneris; Fiscal Year: 1999
    ..Preliminary analysis indicates that Pet-1 is expressed in most or all raphe nuclei, including the laterally extending B9 cluster...
  37. Sleep, Circadian Rhythms and Dementing Illnesses
    David Harper; Fiscal Year: 2007
    ..in target tissue of perifonical area of the hypothalamus, locus coeruleus, midline thalamus and/or dorsal raphe nuclei compared to AD and controls...
  38. Computational Studies of the Respiratory Brainstem
    BRUCE LINDSEY; Fiscal Year: 2006
    ..central pattern generator (CPG), the pontine respiratory group, the nuclei of the solitary tract, and the raphe nuclei. 3...
  39. NEURAL CONTROL OF RESPIRATION
    David Russell; Fiscal Year: 1991
    ..study will be made of the serotonergic innervation of phrenic motorneurons from neurons in the medullary raphe nuclei. The in vitro rat preparation, in conjunction with the bath-application of specific pharmacological agents, ..
  40. MPTP INDUCED MODEL OF PARKINSON'S DISEASE
    Madhu Gupta; Fiscal Year: 1991
    ..morphometric analysis and cell counts in the substantia nigra, the ventral tegmental area, locus coeruleus, and raphe nuclei. Finally, we will pretreat mice with monoamine oxidase inhibitor, deprenil, prior to MPTP treatment to see if ..
  41. EXERCISE PRESSOR RESPONSES AND THE BRAINSTEM
    Gary Iwamoto; Fiscal Year: 1991
    ..medulla including the areas analogous to the C1 area in the rat, and (d) medial medulla including the raphe nuclei, the "dorsomedial pressor region", the nucleus of the tractus solitarius and the inferior olive...
  42. STUDIES OF A MODIFIED SEROTONGERIC PROJECTION
    JOHN HARING; Fiscal Year: 1990
    The widespread efferent projections of serotonergic (5HT) neurons of the brain stem raphe nuclei suggest that this nuclear complex is capable of influencing the activity of extensive regions of the central nervous system (CNS)...
  43. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
  44. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  45. Serotonin Receptor Subtypes: Regulation and Interaction
    JULIE HENSLER; Fiscal Year: 2008
    ..Studies of the regulation of 5-HT1A receptor function may have important implications for our understanding the role of this receptor in the therapeutic action of drugs used to treat mental illness [unreadable] [unreadable]..
  46. 5HT transporter & 1A receptor function in BDNF mice
    JULIE HENSLER; Fiscal Year: 2007
    ..Region-specific and age-dependent changes in BDNF protein levels will be determined in selected brain regions of wild-type and BDNF () mice (Aim #3). [unreadable] [unreadable] [unreadable]..
  47. Dopamine Mechanisms and Receptors in Raphe 5-HT Neurons
    Samir Haj Dahmane; Fiscal Year: 2004
    ....
  48. Neuroanatomical adaptation at synaptic level to chronic
    Feng Zhou; Fiscal Year: 2003
    ..The setting of this threshold might be derailed when alcohol is cyclically deprived. Current and future study along this line will provide information enabling us to better understanding excess drinking behavior. ..
  49. Epigenetics of fetal alcohol syndrome
    Feng Zhou; Fiscal Year: 2009
    ..The effect of these epigenetic key genes will be confirmed in the in vivo model exposed to alcohol vapor chamber with alcohol exposure pattern and paradigms similar to the whole embryonic culture. ..
  50. ALCOHOL & BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESIS
    Feng Zhou; Fiscal Year: 2003
    ....
  51. Emotion, Pain and Pain Control Circuits
    KATHRYN COMMONS; Fiscal Year: 2003
    ..The results of these studies will-yield insight into how distinct modes of stressful stimuli impact SP neurotransmission within neural circuits that coordinate defensive coping strategies. ..
  52. BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSION
    David Wirtshafter; Fiscal Year: 2003
    ..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..
  53. Mechanisms of Stress-Induced Changes in Behavior
    Matthew Cooper; Fiscal Year: 2006
    ..The experiments in the current proposal will provide valuable information on the neurobiological mechanisms underlying stress-related disorders. [unreadable] [unreadable]..
  54. Lateral Hypothalamus, Dopamine and Ingestive Behavior
    David Wirtshafter; Fiscal Year: 2007
    ..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
  55. CIRCUITRY CONTROLLING THE HIPPOCAMPAL THETA RHYTHM
    ROBERT VERTES; Fiscal Year: 2002
    ..This work may have important implications for conditions such as Alzheimer's that involve a loss of cholinergic neurons of the MS/DBv. ..
  56. Brainstem-Diencephalic Modulation of the Hippocampus
    ROBERT VERTES; Fiscal Year: 2006
    ..This work may have important implications for disorders of memory including Korsakoff's syndrome, diencephalic amnesia and Alzheimer's disease. ..
  57. Combining Antidepressants to Hasten Remission from Depression
    Pierre Blier; Fiscal Year: 2010
    ....
  58. Regulation of Serotonin Circuits in Opiate Addiction and Relapse
    Lynn G Kirby; Fiscal Year: 2010
    ..This approach may identify novel targets for the treatment of opiate addiction and the prevention of relapse. ..
  59. Subcortical Estrogen Effect on The Hippocampus
    Csaba Leranth; Fiscal Year: 2005
    ..cholinergic and GABAergic septo-hippocampal neurons involved in mediating estrogenic effect to the hippocampus? and (d) Do SUM neurons mediate estrogenic effect to the hippocampus directly or indirectly, via the MSDB? ..
  60. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..