superior colliculus

Summary

Top Publications

  1. ncbi Target selection and the superior colliculus: goals, choices and hypotheses
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Vision Res 44:1445-51. 2004
  2. ncbi Nociceptive responses of midbrain dopaminergic neurones are modulated by the superior colliculus in the rat
    V Coizet
    Department of Psychology, University of Sheffield, UK
    Neuroscience 139:1479-93. 2006
  3. pmc Superior sensation: superior colliculus participation in rat vibrissa system
    Marie E Hemelt
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Neurosci 8:12. 2007
  4. pmc Dual diffusion model for single-cell recording data from the superior colliculus in a brightness-discrimination task
    Roger Ratcliff
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    J Neurophysiol 97:1756-74. 2007
  5. ncbi The growth factor response in ischemic rat retina and superior colliculus after brimonidine pre-treatment
    Ulrika Lönngren
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Brain Res Bull 71:208-18. 2006
  6. ncbi Organization of the intermediate gray layer of the superior colliculus. I. Intrinsic vertical connections
    Matthew C Helms
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 91:1706-15. 2004
  7. ncbi Population coding strategies and involvement of the superior colliculus in the tactile orienting behavior of naked mole-rats
    S D Crish
    Laboratory of Integrative Neuroscience, and Department of Biological Sciences, University of Illinois at Chicago, 60607, USA
    Neuroscience 139:1461-6. 2006
  8. ncbi Role of the superior colliculus and the intercollicular nucleus in the brainstem seizure circuitry of the genetically epilepsy-prone rat
    Michelle A Merrill
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    Epilepsia 44:305-14. 2003
  9. ncbi The impact of a corticotectal impulse on the awake superior colliculus
    Yulia Bereshpolova
    Department of Psychology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Neurosci 26:2250-9. 2006
  10. ncbi Development of GABAergic neurons from the ventricular zone in the superior colliculus of the mouse
    Naoko Tsunekawa
    Laboratory of Neurochemistry, National Institute for Physiological Sciences and Graduate University for Advanced Studies, Okazaki 444 8585, Japan
    Neurosci Res 51:243-51. 2005

Research Grants

  1. Axonopathy in Glaucoma
    Samuel D Crish; Fiscal Year: 2013
  2. Effects of environmental thyroid hormone disrupting compounds on CNS development
    CHRISTOPHER KIRK THOMPSON; Fiscal Year: 2013
  3. ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLE
    MICHAEL NMN DAVIS; Fiscal Year: 2010
  4. MIDBRAIN CIRCUITRY FOR NEURONAL CONTROL OF GAZE
    Paul J May; Fiscal Year: 2012
  5. RETINAL GANGLION CELL PLASTICITY IN GLAUCOMA
    Vittorio Porciatti; Fiscal Year: 2013
  6. Structure &Function of Ganglion-Cell Photoreceptors Contributing to Form Vision
    MAUREEN ESTRELLITA ESTEVEZ; Fiscal Year: 2013
  7. MOLECULAR REMEDY OF MITOCHONDRIAL DEFECTS
    Takao Yagi; Fiscal Year: 2013
  8. Limbic-Basal Ganglia Circuitry in PTSD
    Ludise Malkova; Fiscal Year: 2013
  9. DEVELOPMENTAL REGULATION OF GLUTAMATE RECEPTOR FUNCTION
    MARTHA NA CONSTANTINE-PATON; Fiscal Year: 2012
  10. ACTIVITY DEPENDENT CONTROL OF VISUAL SYSTEM DEVELOPMENT
    Hollis T Cline; Fiscal Year: 2013

Detail Information

Publications256 found, 100 shown here

  1. ncbi Target selection and the superior colliculus: goals, choices and hypotheses
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Vision Res 44:1445-51. 2004
    The intermediate and deep layers of the superior colliculus (SC) compose a retinotopically organized motor map and are known to be important for the control of saccadic eye movements...
  2. ncbi Nociceptive responses of midbrain dopaminergic neurones are modulated by the superior colliculus in the rat
    V Coizet
    Department of Psychology, University of Sheffield, UK
    Neuroscience 139:1479-93. 2006
    ..In the rat, the superior colliculus is critical for relaying short-latency visual information to dopaminergic neurones...
  3. pmc Superior sensation: superior colliculus participation in rat vibrissa system
    Marie E Hemelt
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Neurosci 8:12. 2007
    The superior colliculus, usually considered a visuomotor structure, is anatomically positioned to perform sensorimotor transformations in other modalities...
  4. pmc Dual diffusion model for single-cell recording data from the superior colliculus in a brightness-discrimination task
    Roger Ratcliff
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    J Neurophysiol 97:1756-74. 2007
    ..Thus the dual diffusion model provides a quantitative account for both the behavior in a simple decision-making task as well as the patterns of activity in competing populations of neurons...
  5. ncbi The growth factor response in ischemic rat retina and superior colliculus after brimonidine pre-treatment
    Ulrika Lönngren
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Brain Res Bull 71:208-18. 2006
    ..Tissue samples of retina and superior colliculus were collected at time points between 6h and 14 days of retinal reperfusion...
  6. ncbi Organization of the intermediate gray layer of the superior colliculus. I. Intrinsic vertical connections
    Matthew C Helms
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 91:1706-15. 2004
    A pathway from the superficial visual layers to the intermediate premotor layers of the superior colliculus has been proposed to mediate visually guided orienting movements...
  7. ncbi Population coding strategies and involvement of the superior colliculus in the tactile orienting behavior of naked mole-rats
    S D Crish
    Laboratory of Integrative Neuroscience, and Department of Biological Sciences, University of Illinois at Chicago, 60607, USA
    Neuroscience 139:1461-6. 2006
    ..In this study we demonstrate that the superior colliculus, a component of the vertebrate midbrain most often thought of as a visual structure, is an essential ..
  8. ncbi Role of the superior colliculus and the intercollicular nucleus in the brainstem seizure circuitry of the genetically epilepsy-prone rat
    Michelle A Merrill
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    Epilepsia 44:305-14. 2003
    ..believed to include the inferior colliculus and other brainstem structures such as the deep layers of the superior colliculus (DLSC), periaqueductal gray, and pontine reticular formation...
  9. ncbi The impact of a corticotectal impulse on the awake superior colliculus
    Yulia Bereshpolova
    Department of Psychology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Neurosci 26:2250-9. 2006
    ..visual cortex, but virtually nothing is known about the synaptic influence of single CTect impulses on the superior colliculus (SC)...
  10. ncbi Development of GABAergic neurons from the ventricular zone in the superior colliculus of the mouse
    Naoko Tsunekawa
    Laboratory of Neurochemistry, National Institute for Physiological Sciences and Graduate University for Advanced Studies, Okazaki 444 8585, Japan
    Neurosci Res 51:243-51. 2005
    The superior colliculus (SC) is a layered structure in the midbrain and is particularly rich in gamma-aminobutyric acid (GABA)...
  11. ncbi Functional topography of converging visual and auditory inputs to neurons in the rat superior colliculus
    Irini Skaliora
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, UK
    J Neurophysiol 92:2933-46. 2004
    ..the infant rat midbrain to examine converging inputs onto neurons in the deeper multisensory layers of the superior colliculus (dSC)...
  12. ncbi Deficits in saccade target selection after inactivation of superior colliculus
    Robert M McPeek
    The Smith Kettlewell Eye Research Institute, 2318 Fillmore Street, San Francisco, California 94115, USA
    Nat Neurosci 7:757-63. 2004
    ..correlated with saccade target selection has been identified in several brain regions, including the superior colliculus (SC), but it is not known whether the SC is directly involved in target selection, or whether the SC merely ..
  13. ncbi Postsynaptic action of BDNF on GABAergic synaptic transmission in the superficial layers of the mouse superior colliculus
    Christian Henneberger
    Developmental Physiology, Johannes Muller Institute of Physiology, Charite, D 10117 Berlin, Germany
    J Neurophysiol 88:595-603. 2002
    ..driven spontaneous network activity and GABAergic inhibition in the superficial layers of the mouse superior colliculus. In this structure neuron survival is unaffected by the absence of BDNF...
  14. ncbi Megane/Heslike is required for normal GABAergic differentiation in the mouse superior colliculus
    Jordi Guimera
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, 35 8006, Ingolstädter Landstrasse, 1, Neuherberg, Germany
    Development 133:3847-57. 2006
    ..and the fifth postnatal week of age, and show a complete depletion of Gad65 and Gad67 expression in the superior colliculus and a reduction in the inferior colliculus...
  15. ncbi Synaptic organization of the rat parafascicular nucleus, with special reference to its afferents from the superior colliculus and the pedunculopontine tegmental nucleus
    Shigeo Kobayashi
    Section of Neuroanatomy, Graduate School of Medical and Dental Research, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Brain Res 980:80-91. 2003
    ..axon terminals, biotinylated dextran amine (BDA) was injected into the main afferent sources of the Pf, the superior colliculus (SC) and the pedunculopontine tegmental nucleus (PPN)...
  16. ncbi Local excitatory network and NMDA receptor activation generate a synchronous and bursting command from the superior colliculus
    Yasuhiko Saito
    Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    J Neurosci 23:5854-64. 2003
    The generation of bursting spike activity in the deeper layers of the superior colliculus (SC) is a critical determinant of decision making in the initiation of orienting behaviors, such as saccades...
  17. ncbi Lack of 5-HT(1B) receptor and of serotonin transporter have different effects on the segregation of retinal axons in the lateral geniculate nucleus compared to the superior colliculus
    A L Upton
    INSERM U106, Hopital de la Pitie Salpetriere, Paris, France
    Neuroscience 111:597-610. 2002
    ..retinal ganglion cell axons from segregating into eye-specific regions in their principal targets: the superior colliculus and the dorsal lateral geniculate nucleus...
  18. ncbi Development of the human superior colliculus and the retinocollicular projection
    Jia Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, 82 Xueyuan Road, Wenzhou, Zhejiang 325003, China
    Exp Eye Res 82:300-10. 2006
    We have used carbocyanine dye tracing from the brachium of the superior colliculus in conjunction with Nissl staining and immunohistochemistry to GAP-43 and calretinin to study the development of retinal projections to the superior ..
  19. ncbi Suppression of absence seizures by electrical and pharmacological activation of the caudal superior colliculus in a genetic model of absence epilepsy in the rat
    K Nail-Boucherie
    Neurobiologie et Neuropharmacologie des Epilepsies Généralisées, INSERM U 398, Faculte de Medecine, Strasbourg, France
    Exp Neurol 177:503-14. 2002
    Activation of the superior colliculus has been shown to reproduce the antiepileptic effect of the inhibition of the substantia nigra reticulata...
  20. ncbi Chemoarchitecture of GABAergic neurons in the ferret superior colliculus
    Mary Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706 1102, USA
    J Comp Neurol 452:334-59. 2002
    ..both in visual processing and in the complex sensory-motor transformations that take place in the mammalian superior colliculus. To understand the organization of GABAergic neurons in the ferret superior colliculus, we applied antisera ..
  21. ncbi Reduced influence of the ipsilateral ear on spatial tuning of auditory neurons in the albino superior colliculus: a knock-on effect of anomalies of the acoustic chiasm?
    Simon Grant
    Division of Neurophysiology, National Institute for Medical Research, Mill Hill, NW7 1AA, London, UK
    Exp Brain Res 151:478-88. 2003
    ..and normally pigmented guinea pigs to the spatial tuning of auditory neurons in the deep layers of the superior colliculus (SC)...
  22. ncbi Neck muscle responses to stimulation of monkey superior colliculus. I. Topography and manipulation of stimulation parameters
    Brian D Corneil
    Canadian Institutes of Health Research Group in Sensory Motor Systems, Centre for Neuroscience Studies, Department of Physiology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Neurophysiol 88:1980-99. 2002
    The role of the primate superior colliculus (SC) in orienting head movements was studied by recording electromyographic (EMG) activity from multiple neck muscles following electrical stimulation of the SC...
  23. ncbi Postnatal innervation of the rat superior colliculus by axons of late-born retinal ganglion cells
    Elizabeth J Dallimore
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Eur J Neurosci 16:1295-304. 2002
    ..Retinal axons first reach the superior colliculus at E16/16.5 but the time of arrival of axons from late-born RGCs is unknown...
  24. ncbi Orienting responses and vocalizations produced by microstimulation in the superior colliculus of the echolocating bat, Eptesicus fuscus
    Doreen E Valentine
    Harvard University, Department of Psychology, Program in Neuroscience, Cambridge, MA 02138, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 188:89-108. 2002
    ..The superior colliculus may function in the coordination of these orienting components of the bat's echolocation system...
  25. ncbi Evidence that the superior colliculus participates in the feedback control of saccadic eye movements
    Robijanto Soetedjo
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    J Neurophysiol 87:679-95. 2002
    ..Although the superior colliculus (SC) is thought to provide the desired saccadic amplitude signal, it is unclear whether the SC resides in ..
  26. pmc Evidence for a role of the parafascicular nucleus of the thalamus in the control of epileptic seizures by the superior colliculus
    Karine Nail-Boucherie
    Neurobiologie et Neuropharmacologie des Epilepsies Généralisées, INSERM U 398, France
    Epilepsia 46:141-5. 2005
    ..nucleus parafascicularis (Pf) of the thalamus could be a relay of the control of epileptic seizures by the superior colliculus (SC)...
  27. ncbi Laminar expression of neurofilament protein in the superior colliculus of the marmoset monkey (Callithrix jacchus)
    James A Bourne
    Department of Physiology, School of Biomedical Sciences, P O Box 13F, Monash University, Clayton, Victoria 3800, Australia
    Brain Res 973:142-5. 2003
    The expression profile of the monoclonal antibody SMI-32 was examined in the superior colliculus of adult marmosets...
  28. ncbi Electrophysiological and morphological properties of identified crossed tecto-reticular neurons in the rat superior colliculus
    Thongchai Sooksawate
    Department of Developmental Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    Neurosci Res 52:174-84. 2005
    Previously we classified randomly sampled neurons in the intermediate layer (SI) of the rat superior colliculus (SC) into six subclasses according to their firing responses to depolarizing current pulses and five subclasses based on ..
  29. ncbi Neuroanatomical approaches of the tectum-reticular pathways and immunohistochemical evidence for serotonin-positive perikarya on neuronal substrates of the superior colliculus and periaqueductal gray matter involved in the elaboration of the defensive beh
    N C Coimbra
    Laboratório de Neuroanatomia e Neuropsicobiologia, Departamento de Morfologia, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo FMRP USP, Ribeirao Preto SP, Avenida dos Bandeirantes, 3900, 14049 900, Brazil
    Exp Neurol 197:93-112. 2006
    Deep layers of the superior colliculus, the dorsal periaqueductal gray matter and the inferior colliculus are midbrain structures involved in the generation of defensive behavior and fear-induced anti-nociception...
  30. ncbi Functional connectivity between the superficial and deeper layers of the superior colliculus: an anatomical substrate for sensorimotor integration
    Timothy P Doubell
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 23:6596-607. 2003
    The superior colliculus (SC) transforms both visual and nonvisual sensory signals into motor commands that control orienting behavior...
  31. ncbi Evidence against a moving hill in the superior colliculus during saccadic eye movements in the monkey
    Robijanto Soetedjo
    Department of Bioengineering and Physiology, University of Washington, Seattle, Washington 98195, USA
    J Neurophysiol 87:2778-89. 2002
    ..and directions are represented in an orderly topographic map across the intermediate and deep layers of the superior colliculus (SC), where large saccades are encoded caudally and small saccades rostrally...
  32. ncbi Synergistic effects of brain-derived neurotrophic factor and chondroitinase ABC on retinal fiber sprouting after denervation of the superior colliculus in adult rats
    Daniela Tropea
    Istituto di Neuroscienze del Consiglio Nazionale delle Ricerche, and Scuola Normale Superiore, 56100 Pisa, Italy
    J Neurosci 23:7034-44. 2003
    ..we characterize treatments that promote the sprouting of undamaged retinal afferents into the denervated superior colliculus (SC) after a partial retinal lesion in the adult rat...
  33. pmc Modulation of GABAergic inhibition in the rat superior colliculus by a presynaptic group II metabotropic glutamate receptor
    S A Neale
    Department of Visual Science, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    J Physiol 577:659-69. 2006
    Previous work has indicated that metabotropic glutamate receptors (mGluRs) modulate visual responses of superior colliculus (SC) neurones in vivo in a variety of ways, in a manner that can be dependent upon visual stimulus properties...
  34. ncbi A direct projection from superior colliculus to substantia nigra for detecting salient visual events
    Eliane Comoli
    Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
    Nat Neurosci 6:974-80. 2003
    ..Here we describe, in the rat, a direct projection from a primary visual structure, the midbrain superior colliculus (SC), to the substantia nigra pars compacta (SNc) where direct synaptic contacts are made with both ..
  35. ncbi Efferent connections of the parabigeminal nucleus to the amygdala and the superior colliculus in the rat: a double-labeling fluorescent retrograde tracing study
    Kamen G Usunoff
    Department of Anatomy and Histology, Faculty of Medicine, Medical University, Sofia 1431, Bulgaria
    Brain Res 1133:87-91. 2007
    The parabigeminal nucleus (Pbg) is a subcortical visual center that besides reciprocal connections with the superior colliculus (SC), also projects to the amygdala (Am)...
  36. ncbi Organization of interlaminar interactions in the rat superior colliculus
    Yasuhiko Saito
    Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    J Neurophysiol 93:2898-907. 2005
    Our previous studies have shown that when slices of the rat superior colliculus (SC) are exposed to a solution containing 10 microM bicuculline and a low concentration of Mg2+ (0...
  37. ncbi Contribution of the primate superior colliculus to inhibition of return
    Michael C Dorris
    Queen s University, Ontario, Canada
    J Cogn Neurosci 14:1256-63. 2002
    ..delineated, and based on indirect but converging evidence, the widely held consensus is that the midbrain superior colliculus (SC) is involved in the generation of IOR...
  38. ncbi Covariant maturation of nocifensive oral behaviour and c-fos expression in rat superior colliculus
    J G McHaffie
    Department of Psychology, University of Sheffield S10 2TP, UK
    Neuroscience 109:597-607. 2002
    ..Previous work has shown this response is dependent on the integrity of the midbrain superior colliculus. The present experiments were initiated to examine the ontogeny of this oral nocifensive reaction and to ..
  39. ncbi Characterisation of rat superficial superior colliculus neurones: firing properties and sensitivity to GABA
    M D Edwards
    Department of Biomedical Sciences, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    Neuroscience 110:93-104. 2002
    Physiological, pharmacological and morphological properties of superficial superior colliculus neurones (n=93) were characterised using whole-cell patch-clamp recordings in rat brain slices...
  40. ncbi Bilateral impact of unilateral visual cortex lesions on the superior colliculus
    R Jarrett Rushmore
    Department of Anatomy and Neurobiology, W 702, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA
    Exp Brain Res 151:542-7. 2003
    We examined the functional impact of a long-standing, unilateral primary visual cortex lesion on the superior colliculus (SC) using radiolabeled 2-deoxyglucose (2DG) as a marker of neural activity...
  41. ncbi Somatosensation in the superior colliculus of the star-nosed mole
    Samuel D Crish
    Laboratory of Integrative Neuroscience, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Comp Neurol 464:415-25. 2003
    The superior colliculus (or optic tectum in nonmammals) plays a critical role in the visual system and is essential for integrating sensory inputs to guide eye and head movements...
  42. ncbi Visual experience is necessary for maintenance but not development of receptive fields in superior colliculus
    M M Carrasco
    Graduate Program in Neurobiology and Behavior, Department of Biology, Georgia State University, 24 Peachtree Center Ave, Atlanta, Georgia 30303, USA
    J Neurophysiol 94:1962-70. 2005
    ..We reported previously that N-methyl-D-aspartate (NMDA) receptor blockade in the superior colliculus of the Syrian hamster prevents refinement of receptive fields (RFs) in normal or compressed retinotopic ..
  43. pmc Direct evidence for the contribution of the superior colliculus in the control of visually guided reaching movements in the cat
    Jean Hubert Courjon
    Espace et Action, Unité 534, INSERM Université Claude Bernard Lyon, IFR19 Institut Fédératif des Neurosciences de Lyon, Bron, France
    J Physiol 556:675-81. 2004
    ..Based on indirect experimental evidence, it has been suggested that the superior colliculus, a subcortical centre known for its key role in controlling rapid orienting gaze shifts, also belongs to ..
  44. ncbi Accommodation and convergence palsy caused by lesions in the bilateral rostral superior colliculus
    Kenji Ohtsuka
    Department of Ophthalmology, Sapporo Medical University, School of Medicine, Hokkaido, Japan
    Am J Ophthalmol 133:425-7. 2002
    To report a patient who developed accommodation and convergence palsy caused by lesions in the bilateral rostral superior colliculus.
  45. ncbi Single trial-based prediction of a go/no-go decision in monkey superior colliculus
    Ryohei P Hasegawa
    Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Neural Netw 19:1223-32. 2006
    ..We performed binary regressions on the activity of single neurons in the superior colliculus (SC), with the go/no-go decision as a predictor variable, and constructed a virtual decision function (VDF) ..
  46. ncbi Anesthetics change the excitation/inhibition balance that governs sensory processing in the cat superior colliculus
    Luis C Populin
    Department of Anatomy and Neuroscience Training Program, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurosci 25:5903-14. 2005
    The superior colliculus (SC) is a midbrain structure that plays a central role in the integration of information from different sensory modalities and the generation of orienting responses...
  47. ncbi EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping
    Robert Hindges
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, 92037, La Jolla, CA 92037, USA
    Neuron 35:475-87. 2002
    ..required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of the superior colliculus (SC)...
  48. ncbi Neuroanatomical and psychopharmacological evidence for interaction between opioid and GABAergic neural pathways in the modulation of fear and defense elicited by electrical and chemical stimulation of the deep layers of the superior colliculus and dorsal
    G C D Eichenberger
    Faculdade de Medicina de Ribeirao Preto, Departamento de Farmacologia, Universidade de Sao Paulo, Lab de Neuroanatomia e Neuropsicobiologia, Avenida dos Bandeirantes 3900, 14049 900, Ribeirao Preto, Brazil
    Neuropharmacology 42:48-59. 2002
    ..of aversive behavioral responses induced by microinjections of bicuculline in the deep layers of the superior colliculus (DLSC) and in dorsal aspects of the periaqueductal gray matter (DPAG), as compared with controls...
  49. ncbi EEG wavelet analyses of the striatum-substantia nigra pars reticulata-superior colliculus circuitry: audiogenic seizures and anticonvulsant drug administration in Wistar audiogenic rats (War strain)
    Franco Rossetti
    Physiology Department, Ribeirao Preto School of Medicine, University of Sao Paulo, Avenida Bandeirantes 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Epilepsy Res 72:192-208. 2006
    ..However, the striato-nigro-tectal circuitry in WARs, a genetically developed strain, seems to have different functional mechanisms when compared with normal rats...
  50. pmc Neural mechanisms of stimulus velocity tuning in the superior colliculus
    Khaleel A Razak
    Department of Biology, Georgia State University, 24 Peachtree Center Ave, Atlanta, GA 30303, USA
    J Neurophysiol 94:3573-89. 2005
    b>Superior colliculus (SC)-mediated control of visuomotor behavior depends on neuronal selectivity for stimulus velocity. However, the mechanism responsible for velocity tuning in SC neurons is unclear...
  51. ncbi Amplitude and direction of saccadic eye movements depend on the synchronicity of collicular population activity
    Michael Brecht
    Max Planck Institut fur medizinische Forschung, Jahnstr 29, 69120 Heidelberg, Germany
    J Neurophysiol 92:424-32. 2004
    ..whether the motion vectors of saccadic eye movements evoked by electrical multisite stimulation of the cat superior colliculus (SC) are influenced by varying the degree of synchrony between the stimulus trains...
  52. ncbi Long-term potentiation in the juvenile superior colliculus requires simultaneous activation of NMDA receptors and L-type Ca2+ channels and reflects addition of newly functional synapses
    Jian Ping Zhao
    The McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 26:12647-55. 2006
    The visual layers of the rodent superficial superior colliculus (sSC) have been the focus of many development studies of the molecular bases of retinotopic map formation, the role of early retinal waves in this process, and the ..
  53. ncbi Decreased metabolic response to visual stimulation in the superior colliculus of mice lacking the glial glutamate transporter GLT-1
    Anne Sophie Herard
    CEA CNRS URA 2210, Service Hospitalier Frederic Joliot, 4, place du General Leclerc, 91401 Orsay Cedex, France
    Eur J Neurosci 22:1807-11. 2005
    ..e. enhancement of glucose uptake) is decreased in the superior colliculus during visual stimulation in young adult mice deficient in the glial glutamate transporter GLT-1...
  54. ncbi Neurofilament proteins are preferentially expressed in descending output neurons of the cat the superior colliculus: a study using SMI-32
    V Fuentes-Santamaria
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Neuroscience 138:55-68. 2006
    ..e. intermediate and deep) laminae of the cat superior colliculus receive converging information from widespread regions of the neuraxis, integrate this information, and ..
  55. ncbi Effects of local nicotinic activation of the superior colliculus on saccades in monkeys
    Masayuki Watanabe
    Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444 8585, Japan
    J Neurophysiol 93:519-34. 2005
    To examine the role of competitive and cooperative neural interactions within the intermediate layer of superior colliculus (SC), we elevated the basal SC neuronal activity by locally injecting a cholinergic agonist nicotine and analyzed ..
  56. ncbi Light-dependent retinal innervation of the rat superior colliculus
    J Roxanne Prichard
    Behavioral Neuroscience Program, University of St Thomas, St Paul, Minnesota 55105, USA
    Anat Rec (Hoboken) 290:341-8. 2007
    ..with a reduction in the distribution of retinal fibers in the stratum opticum of the contralateral superior colliculus. In contrast to the plasticity of the retinocollicular projection, retinal input to sleep, circadian, and ..
  57. ncbi Saccade-related activity in the primate superior colliculus depends on the presence of local landmarks at the saccade endpoint
    Jay A Edelman
    Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, Maryland 20892, USA
    J Neurophysiol 90:1728-36. 2003
    Saccade-related discharge in the superior colliculus is greater for saccades made to a spot of light than for saccades in complete darkness...
  58. ncbi A comparison of macaque behavior and superior colliculus neuronal activity to predictions from models of two-choice decisions
    Roger Ratcliff
    Departments of Psychology and Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurophysiol 90:1392-407. 2003
    ..In the experiment presented here, neural recordings were obtained from superior colliculus prelude/buildup cells in two monkeys while they performed a two-choice task that has been used in humans ..
  59. ncbi Dynamic ensemble coding of saccades in the monkey superior colliculus
    H H L M Goossens
    Department of Medical Physics and Biophysics, Institute for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Neurophysiol 95:2326-41. 2006
    The deeper layers of the midbrain superior colliculus (SC) contain a topographic motor map in which a localized population of cells is recruited for each saccade, but how the brain stem decodes the dynamic SC output is unclear...
  60. ncbi Reward-dependent gain and bias of visual responses in primate superior colliculus
    Takuro Ikeda
    Department of Physiology, School of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Neuron 39:693-700. 2003
    ....
  61. ncbi Altered map of visual space in the superior colliculus of mice lacking early retinal waves
    Thomas D Mrsic-Flogel
    Max Planck Institut fur Neurobiologie, D 82152 Martinsried, Germany
    J Neurosci 25:6921-8. 2005
    ..We used optical imaging of intrinsic signals to visualize the complete retinotopic map in the superior colliculus (SC) of mice lacking early retinal waves, caused by the deletion of the beta2 subunit of the nicotinic ..
  62. ncbi Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system
    Tahira Rashid
    MRC Centre for Developmental Neurobiology, King s College London, New Hunt s House, Guy s Hospital Campus, London SE1 1UL, United Kingdom
    Neuron 47:57-69. 2005
    ..projection in mouse, retinal axons initially overshoot their future termination zones (TZs) in the superior colliculus (SC). The formation of TZs is initiated by interstitial branching at topographically appropriate positions...
  63. ncbi Controlled movement processing: superior colliculus activity associated with countermanded saccades
    Martin Paré
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Neurosci 23:6480-9. 2003
    We investigated whether the monkey superior colliculus (SC), an important midbrain structure for the regulation of saccadic eye movements, contains neurons with activity patterns sufficient to control both the cancellation and the ..
  64. ncbi Distribution across cortical areas of neurons projecting to the superior colliculus in new world monkeys
    Christine E Collins
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, USA
    Anat Rec A Discov Mol Cell Evol Biol 285:619-27. 2005
    ..little is known about the proportions of projections of different areas and regions of neocortex to the superior colliculus in primates...
  65. ncbi Engagement of visual fixation suppresses sensory responsiveness and multisensory integration in the primate superior colliculus
    A H Bell
    Centre for Neuroscience Studies, Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3 N6
    Eur J Neurosci 18:2867-73. 2003
    Neurons in the intermediate and deep layers of the superior colliculus (SC) often exhibit sensory-related activity in addition to discharging for saccadic eye movements...
  66. ncbi Functional circuits mediating sensorimotor integration: quantitative comparisons of projections from rodent barrel cortex to primary motor cortex, neostriatum, superior colliculus, and the pons
    Zachary S Hoffer
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, 17033 2255, USA
    J Comp Neurol 488:82-100. 2005
    ..density and spatial extent of the labeled projections to the primary motor (MI) cortex, neostriatum, superior colliculus, and basal pons...
  67. pmc Microstimulation of the superior colliculus focuses attention without moving the eyes
    JAMES R MULLER
    Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, and Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:524-9. 2005
    The superior colliculus (SC) is part of a network of brain areas that directs saccadic eye movements, overtly shifting both gaze and attention from position to position, in space...
  68. ncbi Phasic activation of substantia nigra and the ventral tegmental area by chemical stimulation of the superior colliculus: an electrophysiological investigation in the rat
    Veronique Coizet
    Department of Psychology, University of Sheffield, Sheffield, S10 2TP, UK
    Eur J Neurosci 17:28-40. 2003
    ..of short-latency visual input to midbrain dopaminergic (DA) neurons is not currently known; however, the superior colliculus (SC) is a subcortical visual structure which has response latencies consistently shorter than those ..
  69. ncbi Representation of an abstract perceptual decision in macaque superior colliculus
    Gregory D Horwitz
    Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurophysiol 91:2281-96. 2004
    We recorded from neurons in the intermediate and deep layers of the superior colliculus (SC) while monkeys performed a novel direction discrimination task...
  70. ncbi Competitive integration of visual and preparatory signals in the superior colliculus during saccadic programming
    Michael C Dorris
    Department of Physiology, Canadian Institutes of Health Research Group in Sensory Motor Systems, Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada K7L3N6
    J Neurosci 27:5053-62. 2007
    ..Motor preparation and visual signals converge in the intermediate and deep layers of the superior colliculus (SC) to influence saccade planning and execution; however, the mechanism by which these sometimes ..
  71. ncbi Effects of eye position upon activity of neurons in macaque superior colliculus
    Michael Campos
    Department of Neurobiology and Physiology, Northwestern University, 2153 N Campus Dr, Evanston, IL 60208 3520, USA
    J Neurophysiol 95:505-26. 2006
    We examined the activity of neurons in the deep layers of the superior colliculus of awake behaving rhesus monkeys during the performance of standard oculomotor tasks as well as during self-guided eye movements made while viewing natural ..
  72. pmc Neonatal cortical ablation disrupts multisensory development in superior colliculus
    Wan Jiang
    Dept of Neurobiology and Anatomy, Wake Forest Univ School of Medicine, Winston Salem, NC 27157 1010, USA
    J Neurophysiol 95:1380-96. 2006
    The ability of cat superior colliculus (SC) neurons to synthesize information from different senses depends on influences from two areas of the cortex: the anterior ectosylvian sulcus (AES) and the rostral lateral suprasylvian sulcus (..
  73. ncbi Spatio-temporal receptive field properties of cells in the rat superior colliculus
    François Prévost
    Centre de Recherche en Neuropsychologie et Cognition, Departement de Psychologie, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Brain Res 1142:80-91. 2007
    ..research, the spatio-temporal receptive field properties of neurons in superficial layers of the superior colliculus are relatively unknown. Extracellular recordings were carried out in anesthetized Long Evans rats...
  74. ncbi Superior colliculus activity related to concurrent processing of saccade goals in a visual search task
    Robert M McPeek
    The Smith Kettlewell Eye Research Institute, San Francisco, California 94115, USA
    J Neurophysiol 87:1805-15. 2002
    ..We recorded single neurons in the superior colliculus (SC) during rapid saccade sequences made by rhesus monkeys performing a search task...
  75. ncbi Manipulating intent: evidence for a causal role of the superior colliculus in target selection
    Christopher D Carello
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, University of California, San Diego, La Jolla, California 92037, USA
    Neuron 43:575-83. 2004
    The superior colliculus (SC) is well known for its role in the motor control of saccades...
  76. ncbi Nicotinic acetylcholine receptor subtypes involved in facilitation of GABAergic inhibition in mouse superficial superior colliculus
    Toshiaki Endo
    Department of Developmental Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
    J Neurophysiol 94:3893-902. 2005
    The superficial superior colliculus (sSC) is a key station in the sensory processing related to visual salience...
  77. ncbi Bimodal interactions in the superior colliculus of the behaving cat
    Luis C Populin
    Department of Anatomy, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurosci 22:2826-34. 2002
    ..responses from two sensory modalities, has been demonstrated in the intermediate layers of the superior colliculus (SCi) and is thought to be a manifestation of a neural mechanism underlying behavioral facilitation to such ..
  78. ncbi Eph/ephrin expression in the adult rat visual system following localized retinal lesions: localized and transneuronal up-regulation in the retina and superior colliculus
    J Rodger
    School of Animal Biology Zoology, The University of Western Australia, 35 Stirling Highway, Crawley 6009, Western Australia
    Eur J Neurosci 22:1840-52. 2005
    ..section in adult PVG hooded rat, the axon guidance cue ephrin-A2 is up-regulated in caudal but not rostral superior colliculus (SC) and the EphA5 receptor is down-regulated in axotomised retinal ganglion cells (RGCs)...
  79. pmc Time-matched pre- and postsynaptic changes of GABAergic synaptic transmission in the developing mouse superior colliculus
    Sergei Kirischuk
    Developmental Physiology, Johannes Muller Institute of Physiology, Humboldt University Medical School Charité, 10117 Berlin, Germany
    J Physiol 563:795-807. 2005
    ..We addressed this question by analysing evoked IPSCs (eIPSCs) in mouse superior colliculus slices between postnatal day (P) 1 and 22...
  80. ncbi Superior colliculus lesions preferentially disrupt multisensory orientation
    L R Burnett
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuroscience 124:535-47. 2004
    The general involvement of the superior colliculus (SC) in orientation behavior and the striking parallels between the multisensory responses of SC neurons and overt orientation behaviors have led to assumptions that these neural and ..
  81. ncbi Commissural excitation and inhibition by the superior colliculus in tectoreticular neurons projecting to omnipause neuron and inhibitory burst neuron regions
    M Takahashi
    Department of Systems Neurophysiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Neurophysiol 94:1707-26. 2005
    ..of tectoreticular neurons (TRNs) in the "fixation " and "saccade " zones of the superior colliculus (SC)...
  82. ncbi Projections from the superior colliculus to the trigeminal system and facial nucleus in the rat
    Céline Dauvergne
    Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, 75251 Paris Cedex 05, France
    J Comp Neurol 478:233-47. 2004
    To determine the influence of the superior colliculus (SC) in orienting behaviors, we examined SC projections to the sensory trigeminal complex, the juxtatrigeminal region, and the facial motor nucleus in rats...
  83. ncbi Cellular dispersion patterns and phenotypes in the developing mouse superior colliculus
    Seong Seng Tan
    Brain Development Group, Howard Florey Institute, Parkville, Victoria, Australia
    Dev Biol 241:117-31. 2002
    The mammalian superior colliculus is structurally and functionally divided into two entities: superficial visual and deep multimodal motor...
  84. ncbi Visual FMRI responses in human superior colliculus show a temporal-nasal asymmetry that is absent in lateral geniculate and visual cortex
    Richard Sylvester
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 17 Queen Square, London WC1N 3AR, UK
    J Neurophysiol 97:1495-502. 2007
    ..been tentatively proposed to reflect possible temporal-nasal differences in the retinotectal pathway to the superior colliculus, rather than in the retinogeniculate pathway or visual cortex...
  85. ncbi Neuronal activity in the rostral superior colliculus related to the initiation of pursuit and saccadic eye movements
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:4333-44. 2003
    ..The superior colliculus (SC) plays a prominent role in the gap effect for saccades, and recent data indicate that this structure ..
  86. pmc Evaluating the operations underlying multisensory integration in the cat superior colliculus
    Terrence R Stanford
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 25:6499-508. 2005
    It is well established that superior colliculus (SC) multisensory neurons integrate cues from different senses; however, the mechanisms responsible for producing multisensory responses are poorly understood...
  87. ncbi Increased c-fos-like immunoreactivity in the superior colliculus and lateral geniculate nucleus of the rd mouse
    Bin Lu
    Department of Ophthalmology and Visual Science, Moran Eye Center, University of Utah Health Science Center, 75 N Medical Drive, Salt Lake City, UT 84132, USA
    Brain Res 1025:220-5. 2004
    ..defect, numbers of FLI-positive cells, identified immunohistochemically, are anomalously elevated in the superior colliculus (SC) and lateral geniculate nucleus (LGN). Eye removal largely prevents the elevated counts...
  88. ncbi Saccade-related spread of activity across superior colliculus may arise from asymmetry of internal connections
    Hiroyuki Nakahara
    Laboratory for Mathematical Neuroscience and for Integrated Theoretical Neuroscience, RIKEN Brain Science Institute, Saitama, Japan
    J Neurophysiol 96:765-74. 2006
    The superior colliculus (SC) receives a retinotopic projection of the contralateral visual field in which the representation of the central field is expanded with respect to the peripheral field...
  89. ncbi Competitive stimulus interactions within single response fields of superior colliculus neurons
    Xiaobing Li
    Department of Physiology, University of Wisconsin Madison Medical School, Madison, Wisconsin 53706, USA
    J Neurosci 25:11357-73. 2005
    In addition to its role in saccade generation, the superior colliculus (SC) is involved in target selection, saccade selection, and shifting the focus of spatial attention...
  90. ncbi Discharge of saccade-related superior colliculus neurons during saccades accompanied by vergence
    Mark M G Walton
    Department of Psychology, University of Alabama, Birmingham 35294, USA
    J Neurophysiol 90:1124-39. 2003
    It has long been believed that the superior colliculus (SC) is involved in the production of saccades but plays no role in the generation of vergence eye movements...
  91. ncbi Stimulus intensity modifies saccadic reaction time and visual response latency in the superior colliculus
    A H Bell
    Centre for Neuroscience Studies, CIHR Group in Sensory Motor Systems, Department of Physiology, Queen s University, Kingston, ON, Canada, K7L 3N6
    Exp Brain Res 174:53-9. 2006
    ..We evaluated this hypothesis by measuring the onset of neural activity in the intermediate layers of the superior colliculus while monkeys generated saccades to high or low-intensity visual stimuli...
  92. ncbi Convergence eye movements evoked by microstimulation of the rostral superior colliculus in the cat
    Shunichi Suzuki
    Department of Ophthalmology, School of Medicine, Sapporo Medical University, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Neurosci Res 49:39-45. 2004
    Results of our previous studies suggest that the circumscribed area in the rostral superior colliculus (SC) of the cat is involved in the control of accommodation. Accommodation is closely linked with vergence eye movements...
  93. ncbi Interaural timing cues do not contribute to the map of space in the ferret superior colliculus: a virtual acoustic space study
    Robert A A Campbell
    University Laboratory of Physiology, University of Oxford, Oxford, Parks Road, Oxford OX1 3PT, UK
    J Neurophysiol 95:242-54. 2006
    ..virtual acoustic space (VAS) stimuli to investigate the representation of auditory space in the superior colliculus (SC) of anesthetized ferrets...
  94. ncbi Ionotropic glutamate receptor GluR2/3-immunoreactive neurons in the cat, rabbit, and hamster superficial superior colliculus
    Won Mee Park
    Department of Biology, College of Natural Sciences, Kyungpook National University, 1370 Sankyuk Dong, Daegu 702 701, South Korea
    Neurosci Res 49:139-55. 2004
    ..of AMPA glutamate receptor subtype GluR2/3 in the superficial layers of cat, rabbit, and hamster superior colliculus (SC) with antibody immunocytochemistry and the effect of enucleation on this distribution...
  95. pmc Kinematics and eye-head coordination of gaze shifts evoked from different sites in the superior colliculus of the cat
    Alain Guillaume
    UMR CNRS 6152 Mouvement et Perception, Faculte des Sciences du Sport, Universite de la Mediterranee, CP 910, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France
    J Physiol 577:779-94. 2006
    Shifting gaze requires precise coordination of eye and head movements. It is clear that the superior colliculus (SC) is involved with saccadic gaze shifts...
  96. pmc Simulations of saccade curvature by models that place superior colliculus upstream from the local feedback loop
    Mark M G Walton
    Deptartment Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurophysiol 93:2354-8. 2005
    ..dual electrode recordings to show that this phenomenon is associated with activity at more than one site in superior colliculus (SC)...
  97. ncbi Cortex controls multisensory depression in superior colliculus
    Wan Jiang
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurophysiol 90:2123-35. 2003
    Multisensory depression is a fundamental index of multisensory integration in superior colliculus (SC) neurons...
  98. ncbi Loss-of-function analysis of EphA receptors in retinotectal mapping
    David A Feldheim
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:2542-50. 2004
    ....
  99. ncbi Evidence for gaze feedback to the cat superior colliculus: discharges reflect gaze trajectory perturbations
    Satoshi Matsuo
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, H3A2B4
    J Neurosci 24:2760-73. 2004
    ..A critical structure in the gaze control circuitry is the superior colliculus (SC) of the midbrain, which drives gaze saccades by relaying cortical commands to brainstem eye and head ..
  100. ncbi Visual detection deficits following inactivation of the superior colliculus in the cat
    Marnie C Fitzmaurice
    Department of Neuroscience, University of Pennsylvania, Philadelphia 19104 6074, USA
    Vis Neurosci 20:687-701. 2003
    Lesion or inactivation of the superior colliculus (SC) of the cat results in an animal that fails to orient toward peripheral visual stimuli which normally evoke a brisk, reflexive orienting response...
  101. ncbi Neuron-specific contribution of the superior colliculus to overt and covert shifts of attention
    Alla Ignashchenkova
    Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
    Nat Neurosci 7:56-64. 2004
    ..Using single-unit recording from the brains of trained rhesus monkeys, we investigated whether the superior colliculus, the major subcortical center for the control of saccades, is part of this shared network for attention and ..

Research Grants65

  1. Axonopathy in Glaucoma
    Samuel D Crish; Fiscal Year: 2013
    ..Retinas, optic nerves, the superior colliculus (SC), and cerebellum (as a control structure) will be harvested and immunoblots will be performed to ..
  2. Effects of environmental thyroid hormone disrupting compounds on CNS development
    CHRISTOPHER KIRK THOMPSON; Fiscal Year: 2013
    ..The goal of this project is to determine how these compounds affect brain development using Xenopus laevis tadpoles as a model species. ..
  3. ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLE
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..evaluate the role of the mesencephalic reticular formation, near the border of the deep white layers of the superior colliculus (deep SC/Me), in fear potentiated startle...
  4. MIDBRAIN CIRCUITRY FOR NEURONAL CONTROL OF GAZE
    Paul J May; Fiscal Year: 2012
    ..the fastigial nucleus, which is believed to modulate near triad responses in an adaptive manner, and the superior colliculus, which has a well known role in saccadic eye movements, but might play a role in the near response, as well...
  5. RETINAL GANGLION CELL PLASTICITY IN GLAUCOMA
    Vittorio Porciatti; Fiscal Year: 2013
    ..We will perform unilateral lesions of the superior colliculus (SC) in C57BL/6J and DBA/2J mice and will quantify changes of the PERG and OCT signal in each eye...
  6. Structure &Function of Ganglion-Cell Photoreceptors Contributing to Form Vision
    MAUREEN ESTRELLITA ESTEVEZ; Fiscal Year: 2013
    ..visual centers of the brain - the dorsal lateral geniculate nucleus of the thalamus (dLGN) and the superior colliculus (SC)...
  7. MOLECULAR REMEDY OF MITOCHONDRIAL DEFECTS
    Takao Yagi; Fiscal Year: 2013
    ..A new animal model has been developed that involves infusion of rotenone-biobeads into the superior colliculus of the rat brain...
  8. Limbic-Basal Ganglia Circuitry in PTSD
    Ludise Malkova; Fiscal Year: 2013
    ..Further, we have discovered that the activation of the intermediate and deep layers of the superior colliculus (DLSC;a midbrain structure) by focal infusions of GABAA antagonist bicuculline, has a profound impact on ..
  9. DEVELOPMENTAL REGULATION OF GLUTAMATE RECEPTOR FUNCTION
    MARTHA NA CONSTANTINE-PATON; Fiscal Year: 2012
    ..Whole-cell patch-clamping in slices from the visual layers of the superior colliculus will determine the effect of these manipulations on synaptic current changes and on electrically evoked LTP ..
  10. ACTIVITY DEPENDENT CONTROL OF VISUAL SYSTEM DEVELOPMENT
    Hollis T Cline; Fiscal Year: 2013
    ..The experiments proposed here should illuminate activity-dependent mechanisms of GABAergic circuit development in vivo. ..
  11. Visual Target Selection for Saccadic Eye Movements
    Michele A Basso; Fiscal Year: 2013
    The overall goal of my research program is to understand the role of the basal ganglia (BG) and superior colliculus (SC) in target selection for saccadic eye movements...
  12. Effects of Hydrogen Peroxide on Substantia Nigra GABAergic Neuron Excitability
    Christian R Lee; Fiscal Year: 2010
    ..of the SNr convey the output of the entire basal ganglia network to target nuclei in the thalamus and superior colliculus. In addition to mediating the physiological role of the basal ganglia in the control of normal movement, it ..
  13. Advances in Oculomotor and Vestibular Systems
    Neeraj J Gandhi; Fiscal Year: 2010
    ..First, we will re-evaluate the actions of the superior colliculus. We will examine whether sensory signals are color-dependent (traditionally, they are assumed not to be) ..
  14. Roles of Ryk and EphB Signaling in Branch Morphogenesis and Topographic Mapping
    ALISHA RICHMAN; Fiscal Year: 2010
    ..This information could then also be used to generate drugs to improve the accurate rewiring of the brain after stroke or other injury, as well as to encourage accurate new circuit formation in patients with neural grafts. ..
  15. The Role of the Activity-Regulated GTPase Rem2 in Dendrite Development
    AMY ELIZABETH GHIRETTI; Fiscal Year: 2013
    ..Ultimately, Rem2 may represent a key molecule through which external stimuli mediate direct effects on those signaling pathways that regulate the structure of individual neurons and the central nervous system as a whole. ..
  16. Behavioral and physiological studies of sound localization
    Tom C T Yin; Fiscal Year: 2013
    ..inferior and superior colliculi with outputs to motor circuits in the brainstem from the deep layers of the superior colliculus. The other circuit involves projections from the inferior colliculus to the medial geniculate and primary ..
  17. Motor learning and memory in health and disease
    Reza Shadmehr; Fiscal Year: 2010
    ..for both reaching and saccades) than the mechanism that initiates the movement (motor cortex for reaching, superior colliculus for saccades)...
  18. Signal Transfer in the Tectothalamic Pathway
    Martha E Bickford; Fiscal Year: 2011
    ..Parallel visual pathways from the retina to the cortex, via the lateral geniculate nucleus (LGN) or via the superior colliculus (SC) and pulvinar nucleus, likely serve distinct functions in the coding of form, movement, and spatial ..
  19. Neural basis of active avoidance behavior
    Manuel A Castro-Alamancos; Fiscal Year: 2013
    ..In these animals, the superior colliculus processes the CS and mediates active avoidance...
  20. EXPERIMENTS ON THE DEVELOPMENT OF NEURAL PATHWAYS
    Martha Constantine Paton; Fiscal Year: 2010
    ..EO) in rodents to synchronize synaptic maturation and plasticity in the superficial visual layers of the superior colliculus (sSC) and in the visual cortex (VC) neurons projecting to the sSC, the corticotectal projection (CTP)...
  21. Dynamic Basal Ganglia Saccade Networks
    Ann M Graybiel; Fiscal Year: 2010
    ..itself projects to the substantia nigra pars reticulata which in turn projects to, and inhibits the superior colliculus and inhibits saccades thereby...
  22. Regulation of nuclei-specific retinogeniculate targeting
    Michael A Fox; Fiscal Year: 2013
    ..targets, and the topographic mapping of RGC axons within the lateral geniculate nucleus (LGN) and superior colliculus (SC)...
  23. Synaptic choices in the retinotectal system
    Joshua R Sanes; Fiscal Year: 2012
    ..and use a novel multicolor transgenic strategy to document laminar patterns of RGC axonal arbors in mouse superior colliculus. Using these strategies we hope to elucidate mechanisms that promote lamina-specific synapse formation and, ..
  24. Genetic approach to the assembly of parallel circuits in the visual system
    Herwig Baier; Fiscal Year: 2010
    ..This study proposes to identify the molecules that are important for this process during development and growth of the vertebrate organism, thus. ..
  25. An in vitro model of saccadic eye movement choice
    Michele A Basso; Fiscal Year: 2013
    ..applicant): The overall goal of this research plan is to understand the role of the basal ganglia (BG) and superior colliculus (SC) in saccadic eye movement choice and decision-making...
  26. Enegetics of neuronal populations by fMRI
    DEWAN SYED FAHMEED HYDER; Fiscal Year: 2013
    ..The thalamus and the superior colliculus are vital for integration of different senses leading to activation of dispersed cortical regions...
  27. A neuronal process of the error signal that drives saccade adaptation
    Yoshiko Kojima; Fiscal Year: 2013
    ..Complex spikes in the OMV originate in a part of the inferior olive that receives a projection from the superior colliculus (SC)...
  28. Cellular basis of visually-guided behavior during development
    Carlos D Aizenman; Fiscal Year: 2012
    ..The tectum, and its mammalian homologue the superior colliculus, receives direct input from the retina as well as from other sensory modalities...
  29. Sensory pathways for stimulus detection during behavior
    Manuel A Castro-Alamancos; Fiscal Year: 2013
    ..to the neocortex in the forebrain (trigeminothalamic), and the other innervates the deep layers of the superior colliculus in the midbrain tectum (trigeminotectal)...
  30. CRCNS: Computational Models of Multisensory Processing
    M Alex Meredith; Fiscal Year: 2010
    ..Although numerous studies have affirmed the role of bimodal integration (especially in the superior colliculus) in detection and orientation behaviors, it is unclear how these dramatic response changes might influence ..
  31. Synaptic choices in the retinotectal system
    Joshua R Sanes; Fiscal Year: 2013
    ..laminar specificity: axons of distinct RGC subsets synapse in specific retinorecipient sublaminae of the superior colliculus, and their dendrites arborize in specific sublaminae of the inner plexiform layer (IPL), where they receive ..
  32. The Zebrafish Connectome
    Florian Engert; Fiscal Year: 2010
    ..We will combine functional imaging using calcium indicators with serial electron microscopy-assisted reconstruction of the zebrafish brain. ..
  33. An optogenetic investigation of cholinergic mechanisms modulating midbrain motor
    ELIZABETH ANN STUBBLEFIELD; Fiscal Year: 2013
    ..brainstem pedunculopontine tegmental nucleus (PPT) to a midbrain area, the intermediate gray layer of the superior colliculus (SC) in the mouse...
  34. INTERNAL SIGNALS IN THE PARIETAL VISUAL PATHWAY
    JOHN ASSAD; Fiscal Year: 2013
    ..Aim 1 also investigates the potential role of the rostral superior colliculus, an area involved in microsaccade generation, in the suppression...
  35. Optogenetic tools to selectively activate projection neurons in awake primate
    John H Reynolds; Fiscal Year: 2012
    ..Our proposal focuses on projections from primary visual cortex (V1) to the superficial layers of the superior colliculus and V1 neurons projecting to the secondary visual area (V2), taking advantage of the well- defined ..
  36. Cholinergic Modulation of Motor Preparation in the Midbrain
    GIDON S FELSEN; Fiscal Year: 2013
    ..input from the brainstem pedunculopontine tegmental nucleus (PPT) to the intermediate gray layer of the superior colliculus (SC) in the mouse...
  37. Involvement of Dopamine in Associative Learning
    ERIC DANIEL HUDGINS; Fiscal Year: 2011
    ..salience of stimuli (independent of their reward value) and that this signal likely derives from the superior colliculus (SC), a subcortical structure lacking the capacity for fine feature discrimination, but specialized for ..
  38. Endocannabinoid-mediated long-term depression in the avian inferior colliculus
    MARIO A PENZO; Fiscal Year: 2010
    ..we intend to elucidate the role of feedback from the Optic Tectum (OT, equivalent to the mammalian superior colliculus) in modulating synaptic strength in the inferior colliculus...
  39. Neural Basis of Saccade Preparation
    Neeraj J Gandhi; Fiscal Year: 2013
    ..The focus is specifically on the superior colliculus, whose rostral pole is involved in preserving fixation and caudal region is essential fo generating ..
  40. Cortical and subcortical control of visual attention
    Robert M McPeek; Fiscal Year: 2011
    ..This project investigates the roles of the superior colliculus (SC) and frontal eye field (FEF) in reflexive and top-down attention shifts...
  41. ipRGC participation and modulation of retinal wave activity
    JORDAN MICHAEL RENNA; Fiscal Year: 2012
    ..to participate in the development of retinotopic maps and the segregation of binocular inputs to the superior colliculus and lateral geniculate nucleus...
  42. Cholinergic mechanisms regulating neuronal responsiveness in the optic tectum
    Carson A Goddard; Fiscal Year: 2010
    ..with spatial attention and under the influence of cholinergic modulation is the optic tectum (called the superior colliculus in mammalian species)...
  43. Neurophysiology of Saccade Adaptation
    Robijanto Soetedjo; Fiscal Year: 2013
    ..Finally, we will activate the putative error signal pathway that drives adaptation by stimulating the superior colliculus, which is the likely source of the error-related climbing fiber activity to the OMV...
  44. Brainstem control of visual orienting
    Edward G Freedman; Fiscal Year: 2010
    ..their role in generation of head movements, and we will record activity simultaneously from cells in the superior colliculus (SC) and cells downstreamfrom the SC in an effort to reveal the underlying mechanisms that transform SC ..
  45. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS D O'LEARY; Fiscal Year: 2013
    ..mechanisms that control the development of the retinotopic map within the projection of RGCs to the superior colliculus (SC), a primary target of RGCs, and the predominant model system for determining mechanisms that control ..
  46. Intertectal input shapes visual circuit development and post injury remodeling
    Abigail Gambrill; Fiscal Year: 2013
    ..The optic tectum is homologous to the mammalian superior colliculus and is critical for processing sensory information from multiple modalities...
  47. In Vivo Properties of Spontaneous Waves in the Retina and Developing Visual Syste
    MICHAEL CRAIR; Fiscal Year: 2013
    ..waves are thought to play a key role in activity-dependent refinement of topographic neural maps in the superior colliculus (SC), lateral geniculate nucleus (LGN), and visual cortex (VCtx)...
  48. Visuomotor functions of ascending pathways to frontal cortex
    Marc A Sommer; Fiscal Year: 2010
    ..Yet the FEF also receives ascending input from pathways originating in subcortical structures including the superior colliculus (SC), the substantia nigra pars reticulata (SNr), and the dentate nucleus (DN)...
  49. Eye Movement Maps in Mouse Superior Colliculus
    Mark A Segraves; Fiscal Year: 2013
    Project Summary/Abstract The mammalian superior colliculus (SC) is a subcortical structure that integrates visual and other sensory information to initiate orienting movements of the eyes and head...
  50. CRCNS: Integrative Information Processing
    Jennifer M Groh; Fiscal Year: 2013
    ..will investigate how information about sound location is encoded in the spike trains of neurons in primate superior colliculus (SC), in comparison to structures that provide inputs to or receive an output from the SC, such as auditory ..
  51. Neural Mechanisms of Visual and Auditory Stimulus Selection
    ERIC KNUDSEN; Fiscal Year: 2013
    ..An understanding of the cellular mechanisms of stimulus selection and the function of cholinergic circuits is crucial for developing treatments that can mitigate or remediate the devastating effects of these conditions. ..
  52. Cortical-Subcortical mechanisms in Orientation Behavior
    JOHN GEORGE MCHAFFIE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The midbrain superior colliculus (SC) requires influence from visual cortex to play its critical role in subserving contralateral visual orientation: unilateral visual cortex lesions eliminate this ..
  53. ANATOMY OF IDENTIFIED CELL POPULATIONS IN VISUAL CORTEX
    BARBARA MC GUIRE; Fiscal Year: 1991
    ..is probably a heterogeneous one, with some cells projecting to area MT and some projecting to the superior colliculus. Layer 4B also contains a heterogeneous group of neurons, with certain cells projecting to area MT and ..
  54. Development of retinofugal parallel pathways
    Andrew D Huberman; Fiscal Year: 2013
    ..3) test the hypothesis that lamina specific targeting of axons from direction selective RGCs to the superior colliculus is mediated by the adhesion molecule cadherin-7...
  55. OROFACIAL PAIN PATHWAYS
    BARRY GRUNWERG; Fiscal Year: 1993
    ..Older anatomical and behavioral studies suggested an involvement of the superior colliculus in central pain mechanisms and some recent neurophysiological results support this claim...
  56. Neuronal basis for sensorimotor control during zebrafish prey capture behavior
    TOD ROGERS THIELE; Fiscal Year: 2010
    ..Given the high degree of conservation across vertebrates, circuit mapping coupled with the vast pool of genetic data and tools in zebrafish should provide a powerful combination for gaining insights into human neurological diseases. ..
  57. Functional Characterization of Spatial Neglect in Parkinson's Disease
    DANIEL JAMES NORTON; Fiscal Year: 2013
    ..structures that are pathological in PD, such as parietal lobes and areas basal ganglia circuits modulating superior colliculus activity, it is hypothesized that attention, rather than spatial compression, accounts for the hemineglect ..
  58. The Control of Nonhuman Primate Motor and Emotional Behavior
    Angela Holmes; Fiscal Year: 2009
    ..substantial nigra pars reticulata (SNpr), and one of its principle target regions, the deep layers of the superior colliculus (DSC)...
  59. Mechanisms of Visual Map Development in the Superior Colliculus
    MICHAEL CRAIR; Fiscal Year: 2012
    ..Prominent examples are the maps of eye-preference and retinotopy in the lateral geniculate nucleus, superior colliculus and visual cortex...
  60. Eye Movement Control-Role of Brain Stem Neurons
    John Maunsell; Fiscal Year: 2005
    ..More specifically, the proposed experiments study the role of the primate superior colliculus (SC) and the pontomedullary reticular formation in the control of orienting movements of the eyes and head...
  61. MOLECULAR MECHANISMS OF NEURONAL CELL MIGRATION
    Richard Cameron; Fiscal Year: 2000
    ....
  62. CORTICAL CONTRIBUTIONS TO THE CONTROL OF EYE MOVEMENTS
    Mark Segraves; Fiscal Year: 2004
    ..The FEF contains neurons whose firing is related to the generation of saccades, and projects to the superior colliculus as well as to other oculomotor regions of the brainstem...
  63. Frontal Cortex Control of Gaze Shifts
    LONGTANG CHEN; Fiscal Year: 2003
    ..e., coordinated movements of the eyes and head), as in the superior colliculus and other brainstem sites...
  64. Development of Multisensory Integration
    Barry E Stein; Fiscal Year: 2013
    ..Indeed, the superior colliculus (SC) model from which most of the data were collected also showed that the nature of early cross-modal ..
  65. NEURAL CONTROL OF GOAL DIRECTED HEAD MOVEMENT
    ERIC KNUDSEN; Fiscal Year: 1992
    ..The owl's optic nerve tectum (superior colliculus) issues commands that redirect the head to stimulus sources; the site activity in the tectum represents the ..