mesencephalon

Summary

Top Publications

  1. ncbi Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
    Jong Hoon Kim
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 418:50-6. 2002
  2. ncbi The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
    W Wisden
    Laboratory of Molecular Neuroendocrinology, Zentrum fur Molekulare Biologie, University of Heidelberg, Germany
    J Neurosci 12:1040-62. 1992
  3. pmc Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    Alfonso Abizaid
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
    J Clin Invest 116:3229-39. 2006
  4. pmc Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat
    R G Nair-Roberts
    Department of Zoology, University of Oxford, South Parks Rd, Oxford, OX1 3PS, UK Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3US, UK
    Neuroscience 152:1024-31. 2008
  5. pmc Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
    O Saucedo-Cardenas
    Department of Cell Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 95:4013-8. 1998
  6. ncbi Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 293:607-17. 2000
  7. ncbi Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
    Sandra Blaess
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 133:1799-809. 2006
  8. pmc Genetic networks controlling the development of midbrain dopaminergic neurons
    Nilima Prakash
    GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstr 1, D 85764 Munich Neuherberg, Germany
    J Physiol 575:403-10. 2006
  9. ncbi The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
    Candace L Chi
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Development 130:2633-44. 2003
  10. ncbi Neural plate patterning: upstream and downstream of the isthmic organizer
    W Wurst
    Institute of Mammalian Genetics, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Nat Rev Neurosci 2:99-108. 2001

Research Grants

  1. TNF Signaling in Neurodegeneration
    MARIALOURDES G TANSEY; Fiscal Year: 2010
  2. Activation of GPR37 and GPR37L1 by prosaptide, a neuroprotective peptide
    Randy A Hall; Fiscal Year: 2013
  3. Nigrostriatal Tract Reconstruction
    JOHN RICHARD SLADEK; Fiscal Year: 2010
  4. The Synaptic Origin of Reward Prediction Error Signal in Dopaminergic Neurons
    CARLOS ANTONIO PALADINI; Fiscal Year: 2013
  5. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2005
  6. EYELID SENSORIMOTOR NETWORKS
    Mark leDoux; Fiscal Year: 2003
  7. PRE & POSTSYNAPTIC NICOTINIC ACHRS--STRUCTURE & FUNCTION
    Peter Sargent; Fiscal Year: 1999
  8. Roles of neurotrophic factors in dental pulp innervation
    Christopher Nosrat; Fiscal Year: 2003
  9. GENETIC CONTROL OF MID-HIND BRAIN PATTERNING
    Alexandra Joyner; Fiscal Year: 1999
  10. DOPAMINERGIC NEUROTROPHIC FACTORS AND TOURETTE SYNDROME
    MEG PALMATIER; Fiscal Year: 1999

Detail Information

Publications281 found, 100 shown here

  1. ncbi Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
    Jong Hoon Kim
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 418:50-6. 2002
    ..The dopamine neurons generated by these stem cells show electrophysiological and behavioural properties expected of neurons from the midbrain. Our results encourage the use of ES cells in cell-replacement therapy for Parkinson's disease...
  2. ncbi The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
    W Wisden
    Laboratory of Molecular Neuroendocrinology, Zentrum fur Molekulare Biologie, University of Heidelberg, Germany
    J Neurosci 12:1040-62. 1992
    ..Based on significant mismatches between alpha 4/delta and gamma mRNAs, we suggest that in vivo, the alpha 4 subunit contributes to GABAA receptors that lack BZ modulation...
  3. pmc Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    Alfonso Abizaid
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
    J Clin Invest 116:3229-39. 2006
    ..Taken together, these data suggest that the mesolimbic reward circuitry is targeted by peripheral ghrelin to influence physiological mechanisms related to feeding...
  4. pmc Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat
    R G Nair-Roberts
    Department of Zoology, University of Oxford, South Parks Rd, Oxford, OX1 3PS, UK Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3US, UK
    Neuroscience 152:1024-31. 2008
    ....
  5. pmc Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
    O Saucedo-Cardenas
    Department of Cell Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 95:4013-8. 1998
    ..Taken together, these data indicate that Nurr1 is essential for both survival and final differentiation of ventral mesencephalic late dopaminergic precursor neurons into a complete dopaminergic phenotype...
  6. ncbi Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 293:607-17. 2000
    ....
  7. ncbi Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
    Sandra Blaess
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 133:1799-809. 2006
    ..Thus, the precise spatial and temporal regulation of Gli2A and Gli3R by Shh is instrumental in coordinating mid/hindbrain development in three dimensions...
  8. pmc Genetic networks controlling the development of midbrain dopaminergic neurons
    Nilima Prakash
    GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstr 1, D 85764 Munich Neuherberg, Germany
    J Physiol 575:403-10. 2006
    ..We will summarize these new findings in the overall context of midbrain dopaminergic neuron development in this review...
  9. ncbi The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
    Candace L Chi
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Development 130:2633-44. 2003
    ..and cerebellum develop from a region of the early neural tube comprising two distinct territories known as the mesencephalon (mes) and rostral metencephalon (met; rhombomere 1), respectively...
  10. ncbi Neural plate patterning: upstream and downstream of the isthmic organizer
    W Wurst
    Institute of Mammalian Genetics, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Nat Rev Neurosci 2:99-108. 2001
    ..Here we review our current knowledge on the identity, localization and maintenance of the isthmic organizer, as well as on the molecular cascades that underlie the activity of this organizing centre...
  11. ncbi Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon
    Xiaoying Cui
    Queensland Brain Institute, University of Queensland, QLD 4072, Australia
    Neurosci Lett 486:220-3. 2010
    ..to examine the expression of genes important for dopaminergic development and maturation within the embryonic mesencephalon using an epidemiologically-informed animal model of schizophrenia, the developmental vitamin D (DVD) deficient ..
  12. pmc Derivation of midbrain dopamine neurons from human embryonic stem cells
    Anselme L Perrier
    Laboratory of Stem Cell and Tumor Biology, Division of Neurosurgery and Developmental Biology Program, and Cell Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:12543-8. 2004
    ..This experimental system also provides a powerful tool to probe the molecular mechanisms that control the development and function of human midbrain DA neurons...
  13. ncbi Reward-related FMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation
    Bianca C Wittmann
    Department of Neurology II and, Centre for Advanced Imaging, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Neuron 45:459-67. 2005
    ..These data are consistent with the hypothesis that activation of dopaminergic midbrain regions enhances hippocampus-dependent memory formation, possibly by enhancing consolidation...
  14. ncbi Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
    K R Thomas
    Howard Hughes Medical Institute, Department of Biology and Human Genetics, Salt Lake City, Utah 84112
    Nature 346:847-50. 1990
    ..int-1-/int-1- mice at several stages of embryogenesis revealed severe abnormalities in the development of the mesencephalon and metencephalon indicating a prominent role for the int-1 protein is in the induction of the mesencephalon ..
  15. ncbi Regionally specified human neural progenitor cells derived from the mesencephalon and forebrain undergo increased neurogenesis following overexpression of ASCL1
    Hyun Jung Kim
    Department of Anatomy, University of Wisconsin Madison, Madison, Wisconsin, USA
    Stem Cells 27:390-8. 2009
    ..Although this restores neuronal production with a region-specific phenotype, it does not restore full neurochemical maturation, which may require additional factors...
  16. pmc Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice
    Clare L Parish
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    J Clin Invest 118:149-60. 2008
    ....
  17. ncbi Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    V Brault
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:1253-64. 2001
    ..Our results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development...
  18. ncbi Roles of subthreshold calcium current and sodium current in spontaneous firing of mouse midbrain dopamine neurons
    Michelino Puopolo
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 27:645-56. 2007
    ..The results also show a significant contribution of subthreshold TTX-sensitive sodium current...
  19. ncbi Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 19:533-42. 2005
    ..Finally, NADPH oxidase could be an ideal target for potential pharmaceutical intervention, given that it plays a critical role in alpha-synuclein-mediated microglial activation and associated neurotoxicity...
  20. ncbi Dopaminergic transplantation for Parkinson's disease: current status and future prospects
    C Warren Olanow
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 66:591-6. 2009
    ..have failed to meet their primary endpoints, and transplantation of dopamine cells derived from the fetal mesencephalon is associated with a potentially disabling form of dyskinesia that persists even after withdrawal of levodopa (..
  21. ncbi Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon
    Daniela Omodei
    CEINGE Biotecnologie Avanzate, Via Comunale Margherita 482, 80145 Naples, Italy
    Development 135:3459-70. 2008
    ..Otx2 is required for the establishment of the mesencephalic field and molecular code of the entire ventral mesencephalon (VM)...
  22. ncbi GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    L F Lin
    Synergen, Inc, Boulder, CO 80301
    Science 260:1130-2. 1993
    ..GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons...
  23. pmc Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
    Mianzhi Tang
    Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 30:9280-91. 2010
    ..Persistent activation of beta-catenin in early progenitors perturbs their cell cycle progression and antagonizes Shh expression, whereas activation of beta-catenin in midline progenitors promotes the generation of dopamine neurons...
  24. pmc Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry, and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:12747-52. 2003
    ..These findings indicate that Wnts are key regulators of proliferation and differentiation of DA precursors during VM neurogenesis and that different Wnts have specific and unique activity profiles...
  25. ncbi Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis
    Milan Joksimovic
    Northwestern University Feinberg Medical School, Department of Neurology and Center for Genetic Medicine, 7 113 Lurie Bldg, 303 E Superior Street, Chicago, Illinois 60611, USA
    Nat Neurosci 12:125-31. 2009
    ..These findings demonstrate how the dynamic interplay of canonical Wnt/beta-catenin signaling and Shh may orchestrate floor plate neurogenesis or a lack thereof...
  26. ncbi Modulation power and phase spectrum of natural sounds enhance neural encoding performed by single auditory neurons
    Anne Hsu
    Neuroscience Institute and Department of Physics, University of California, Berkeley, Berkeley, California 94720 1650, USA
    J Neurosci 24:9201-11. 2004
    ..We found that rate distribution and bandwidth but not reliability were responsible for the higher average information rates found for song-like sounds...
  27. ncbi Development of dopaminergic neurons in the mammalian brain
    N Prakash
    GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstr 1, 85764 Munich Neuherberg, Germany
    Cell Mol Life Sci 63:187-206. 2006
    ..In the present review, we provide an overview of the mechanisms and factors involved in the development of dopaminergic neurons in the mammalian brain, with a special emphasis on the midbrain dopaminergic population...
  28. pmc Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway
    Sangmi Chung
    Department of Psychiatry and Program in Neuroscience, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Cell Stem Cell 5:646-58. 2009
    ..Together with previous works, this study shows that two regulatory loops (Wnt1-Lmx1a and SHH-FoxA2) critically link extrinsic signals to cell-intrinsic factors and cooperatively regulate mDA neuron development...
  29. ncbi Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons
    Banafsheh Kadkhodaei
    Ludwig Institute for Cancer Research, Stockholm Branch, SE 171 77 Stockholm, Sweden
    J Neurosci 29:15923-32. 2009
    ....
  30. ncbi Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells
    Elisabet Hermanson
    Ludwig Institute for Cancer Research, Stockholm Branch, P O Box 240, S 171 77 Stockholm, Sweden
    Exp Cell Res 288:324-34. 2003
    ..Together, the results provide evidence indicating an instructive role for Nurr1 in controlling DA synthesis and storage...
  31. pmc Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei
    Sandra Blaess
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Neural Dev 6:29. 2011
    ..Given these dynamic gene expression patterns, Shh and Gli1 expression could delineate different progenitor populations at distinct embryonic time points...
  32. ncbi Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner
    Anna L M Ferri
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:2761-9. 2007
    ..Altogether, our results demonstrate that Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner...
  33. pmc Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells
    Stina Friling
    The Ludwig Institute for Cancer Research, Karolinska Institutet, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:7613-8. 2009
    ..Thus, the enriched generation of functional mesDA neurons by forced expression of Lmx1a may be of future importance in cell replacement therapy of Parkinson disease...
  34. ncbi Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region
    Markus Panhuysen
    Institute of Developmental Genetics, GSF Research Center for Environment and Health, 85764 Neuherberg, Germany
    Mol Cell Neurosci 26:101-11. 2004
    ..We suggest that Wnt1 acts as a regulator of proliferation of specific precursor populations in the developing mid-/hindbrain region and is only secondarily involved in maintenance of the mid-/hindbrain organizer...
  35. ncbi The dual dopamine-glutamate phenotype of growing mesencephalic neurons regresses in mature rat brain
    Noémie Bérubé-Carrière
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Comp Neurol 517:873-91. 2009
    ..These results suggest a regression of the VGLUT2 phenotype of dopamine neurons with age, following normal development, lesion, or sprouting after injury, and a role for glutamate in the establishment of synapses by these neurons...
  36. pmc Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals
    Jeremy J Clark
    Department of Psychiatry and Behavioral Sciences and Department of Pharmacology, University of Washington, Seattle, Washington, USA
    Nat Methods 7:126-9. 2010
    ..Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice...
  37. ncbi Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation
    D Acampora
    International Institute of Genetics and Biophysics CNR, Naples, Italy
    Development 121:3279-90. 1995
    ....
  38. ncbi Dissecting the diversity of midbrain dopamine neurons
    Jochen Roeper
    Institute of Neurophysiology, Neuroscience Center, Goethe University, Frankfurt, Germany
    Trends Neurosci 36:336-42. 2013
    ....
  39. ncbi Transcranial sonography in movement disorders
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Lancet Neurol 7:1044-55. 2008
    ..Thus, this neuroimaging method could be recommended for general application in the diagnosis and differential diagnosis of PD...
  40. ncbi Specification of the meso-isthmo-cerebellar region: the Otx2/Gbx2 boundary
    Matias Hidalgo-Sanchez
    INSERM U106, Hopital de la Salpetriere, Pavillon Enfants et Adolescents, 75651 Paris Cedex 13, France
    Brain Res Brain Res Rev 49:134-49. 2005
    ..Otx2 and Gbx2 co-regulation could determine the precise location of the MH boundary and involved in the inductive events characteristic of the isthmic organizer center...
  41. ncbi Morphology and connections of nucleus isthmi pars magnocellularis in chicks (Gallus gallus)
    Yuan Wang
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    J Comp Neurol 469:275-97. 2004
    ..The laminar and columnar pattern of isthmotectal terminals also suggests a means of interacting with multiple tectofugal pathways, including the stratified subpopulations of tectorotundal neurons participating in motion detection...
  42. ncbi Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures
    Rudolf Moldzio
    Institute of Chemistry and Biochemistry, Department for Biomedical Sciences, University for Veterinary Medicine, Veterinaerplatz 1, A 1210 Vienna, Austria
    Phytomedicine 19:819-24. 2012
    ..Even though no significant preservation or recovery of neurite outgrowth to control values could be observed, our data show that cannabinoids THC and THCA protect dopaminergic neurons against MPP(+) induced cell death...
  43. ncbi A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging
    Paul Dunckley
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    J Neurosci 25:7333-41. 2005
    ..05, Pearson's r, two-tailed) but not somatic stimulation. We propose that the differences in NCF and right PAG activation observed may represent a greater nocifensive response and greater emotive salience of visceral over somatic pain...
  44. ncbi Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon
    Tomoya Nakatani
    KAN Research Institute Inc, Kobe MI R and D Center, 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Dev Biol 339:101-13. 2010
    ..We also found that, in the mesencephalon, FP cell fate is primarily determined by Foxa2 with a supportive action of Lmx1a/b through repressing Nkx6...
  45. ncbi Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity
    Yannis E Mavromatakis
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Mech Dev 128:90-103. 2011
    ..Altogether, these data indicate that Foxa1 and Foxa2 contribute to the specification of ventral midbrain progenitor identity by regulating Shh signalling in a positive and negative manner...
  46. ncbi Effect of GDNF on differentiation of cultured ventral mesencephalic dopaminergic and non-dopaminergic calretinin-expressing neurons
    Benoit Schaller
    Department of Neurosurgery, University of Bern, CH 3010 Bern, Switzerland
    Brain Res 1036:163-72. 2005
    ..These cells were identified as GABA-expressing neurons. In conclusion, our findings recognize GDNF as a potent differentiation factor for the development of VM dopaminergic and non-dopaminergic CR-expressing neurons...
  47. pmc Reciprocal inhibition of inhibition: a circuit motif for flexible categorization in stimulus selection
    Shreesh P Mysore
    Department of Neurobiology, Stanford University, 299 W Campus Drive, Stanford, CA 94305, USA
    Neuron 73:193-205. 2012
    ..The results demonstrate the extraordinary power of a remarkably simple, neurally grounded circuit motif in producing flexible categorization, a computation fundamental to attention, perception, and decision making...
  48. ncbi Specification of dorsoventral polarity in the embryonic chick mesencephalon and its presumptive role in midbrain morphogenesis
    Naixin Li
    JRG Developmental Neurobiology, Biocentre, University of Wuerzburg, Wuerzburg, Germany
    Dev Dyn 233:907-20. 2005
    ....
  49. pmc Characterizing the mesencephalon using susceptibility-weighted imaging
    E S Manova
    Department of Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA
    AJNR Am J Neuroradiol 30:569-74. 2009
    The mesencephalon is involved in a number of human neurodegenerative disorders and has been typically imaged with T1-, T2- and T2*-weighted methods...
  50. ncbi Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson's disease
    E M Torres
    Department of Biosciences, Biomedical Sciences Building, Museum Avenue, Cardiff University, PO Box 911 Cardiff South Glamorgan, UK
    Neuroscience 154:631-40. 2008
    ....
  51. ncbi Dopamine neuron agenesis in Nurr1-deficient mice
    R H Zetterström
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Science 276:248-50. 1997
    ..These results suggest that putative Nurr1 ligands may be useful for treatment of Parkinson's disease and other disorders of midbrain dopamine circuitry...
  52. pmc Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells
    Emily Gale
    MRC Clinical Sciences Centre, Imperial College London, UK
    Mol Brain 1:8. 2008
    ..involved in the development of mDA neurons, including the induction of mDA neuron progenitors in the ventral mesencephalon, the specification of the mDA neuronal fate and the maintenance of postmitotic mDA neurons...
  53. ncbi Establishment of an immortalized GABAergic neuronal progenitor cell line from embryonic ventral mesencephalon in the rat
    Beibei Wang
    Beijing Institute for Neuroscience, Capital Medical University, Beijing Center of Neural Regeneration and Repair, Key Laboratory of Neurodegenerative diseases of Ministry of Education of China, Beijing 100069, China
    Brain Res 1210:63-75. 2008
    ..controlled immortalized GABAergic neuronal progenitor cell line (RMNE6) was established from E13 rat ventral mesencephalon cells immortalized using the temperature-sensitive mutant of SV40 large T antigen (ts-TAg)...
  54. ncbi The dopaminergic mesencephalic projections to the hippocampal formation in the rat
    A Gasbarri
    Department of Sciences and Biomedical Technologies, University of L Aquila, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 21:1-22. 1997
    ..The functional significance of the mesohippocampal dopaminergic system is largely unknown, although it was suggested that this projection could have a role in methamphetamine-produced hypermotility and in modulation of memory processes...
  55. ncbi Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    Hui Ming Gao
    Neuropharmacology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 22:782-90. 2002
    ..Using primary neuron-enriched and neuron/glia cultures from the rat mesencephalon, we discovered an extraordinary feature for rotenone-induced degeneration of cultured dopaminergic neurons...
  56. pmc Anesthetic state modulates excitability but not spectral tuning or neural discrimination in single auditory midbrain neurons
    Joseph W Schumacher
    Doctoral Program in Neurobiology and Behavior, Columbia University, New York, NY 10027, USA
    J Neurophysiol 106:500-14. 2011
    ....
  57. ncbi Improved survival of young donor age dopamine grafts in a rat model of Parkinson's disease
    E M Torres
    Department of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff CF10 3US, UK
    Neuroscience 146:1606-17. 2007
    ..We consider the in vivo conditions which allow this differentiation to occur, and the implications for the future of clinical trials based on dopamine cell replacement therapy...
  58. ncbi Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect
    Sebastian Stuebner
    Institute of Developmental Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, and Technical University Munich, Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Munich Neuherberg, Germany
    Dev Dyn 239:246-60. 2010
    ..Fzd3 and Fzd6 thus control proper midbrain morphogenesis by a yet unknown mechanism in the mouse...
  59. ncbi Migration of dopaminergic neurons in the embryonic mesencephalon of mice
    H Kawano
    Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan
    Brain Res Dev Brain Res 86:101-13. 1995
    ..Migration of dopamine (DA)-containing neurons and its guiding cues were histologically examined in the embryonic mesencephalon of normal mice...
  60. ncbi Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
    P Urbanek
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 79:901-12. 1994
    ..These data define a key role for Pax5 in early B lymphopoiesis and midbrain patterning...
  61. ncbi Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons
    Dong Youn Hwang
    Molecular Neurobiology Laboratory, McLean Hospital and Harvard Medical School, Belmont, MA, USA
    J Neurochem 111:1202-12. 2009
    ....
  62. ncbi Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+ sensitivity of SK channels
    Huifang Ji
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Eur J Neurosci 29:1883-95. 2009
    ....
  63. ncbi A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo
    Makoto Ishibashi
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 129:4807-19. 2002
    ....
  64. ncbi Towards stem cell replacement therapies for Parkinson's disease
    Ernest Arenas
    Laboratory of Molecular Neurobiology, MBB, Center for Developmental Biology and Regenerative Medicine, Scheelevagen 1, 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 396:152-6. 2010
    ....
  65. ncbi Transient high-frequency firing in a coupled-oscillator model of the mesencephalic dopaminergic neuron
    Alexey S Kuznetsov
    Center for BioDynamics and Mathematics Department, Boston University, Boston, Massachusetts, USA
    J Neurophysiol 95:932-47. 2006
    ....
  66. ncbi Semaphorins 3A, 3C, and 3F in mesencephalic dopaminergic axon pathfinding
    Hebert L Hernandez-Montiel
    Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico
    J Comp Neurol 506:387-97. 2008
    ..These results suggest that semaphorins may help to establish the dopaminergic projection from the midbrain to the striatum during embryonic development...
  67. ncbi Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors
    Carol H Yan
    Department of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Neurosci 31:12413-25. 2011
    ..Together, our results demonstrate that Lmx1a and Lmx1b function cooperatively to regulate proliferation, specification, and differentiation of mDA progenitors, including their floor plate-like properties...
  68. ncbi Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain
    Daniel A Berg
    Karolinska Institute, Department for Cell and Molecular Biology, Stockholm 17177, Sweden
    Development 137:4127-34. 2010
    ..This strategy identified hedgehog signalling as a key component of adult dopamine neuron regeneration. These data show that brain regeneration can occur by activation of neurogenesis in quiescent brain regions...
  69. ncbi Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain
    Eduardo Puelles
    MRC Centre for Developmental Neurobiology, New Hunt s House, 4th Floor, King s College London, Guy s Campus, London Bridge, London SE1 1UL, UK
    Development 131:2037-48. 2004
    ....
  70. ncbi Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
    Marten P Smidt
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 131:1145-55. 2004
    ..However, an overall lower activity was observed. The results suggest that Pitx3 is specifically required for the formation of the SNc subfield at the onset of dopaminergic neuron differentiation...
  71. pmc Functional groups in the avian auditory system
    Sarah M N Woolley
    Department of Psychology, Columbia University, New York, New York 10027, USA
    J Neurosci 29:2780-93. 2009
    ..Comparing STRFs in midbrain and forebrain neurons suggested that both inheritance and emergence of tuning properties occur as information ascends the auditory processing stream...
  72. ncbi Particular subpopulations of midbrain and hypothalamic dopamine neurons express vesicular glutamate transporter 2 in the rat brain
    Michihiro Kawano
    Laboratory of Neuroendocrinology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    J Comp Neurol 498:581-92. 2006
    ..These results indicate that VGLUT2 is expressed in subsets of A10 and A11 dopamine neurons, which might release dopamine and glutamate separately from different varicosities in the majority of their single axons...
  73. ncbi Discrete coding of reward probability and uncertainty by dopamine neurons
    Christopher D Fiorillo
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 299:1898-902. 2003
    ..The coding of uncertainty suggests a possible role for dopamine signals in attention-based learning and risk-taking behavior...
  74. ncbi Vitamin D(3) attenuates 6-hydroxydopamine-induced neurotoxicity in rats
    J Y Wang
    Department of Physiology, National Defense Medical Center, Taipei, Taiwan
    Brain Res 904:67-75. 2001
    ..Since both H(2)O(2) and 6-OHDA may injure cells via free radical and reactive oxygen species, the neuroprotection seen here may operate via a reversal of such a toxic mechanism...
  75. pmc Oxidative inactivation of mitochondrial aconitase results in iron and H2O2-mediated neurotoxicity in rat primary mesencephalic cultures
    David Cantu
    Neuroscience Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    PLoS ONE 4:e7095. 2009
    ..The goal of this study was to determine if oxidative inactivation of mitochondrial aconitase (m-aconitase) resulted in the release of redox-active iron (Fe2+) and hydrogen peroxide (H2O2) and whether this contributes to cell death...
  76. ncbi Nonlinear spectrotemporal sound analysis by neurons in the auditory midbrain
    Monty A Escabi
    W M Keck Center for Integrative Neuroscience and University of California San Francisco University of California Berkeley Joint Bioengineering Graduate Group, University of California, San Francisco, California 94143, USA
    J Neurosci 22:4114-31. 2002
    ..Our findings delineate rules for spectrotemporal integration in the ICC that cannot be accounted for by conventional linear-energy integration models...
  77. ncbi FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F
    Kenta Yamauchi
    Laboratory of Neuroscience, Graduate School of Frontier Biosciences, Osaka University, Suita 565 0871, Japan
    J Neurosci 29:4044-55. 2009
    ..These results indicate that the MHB signaling center regulates the growth polarity of mDAN axons along the RC axis by inducing sema3F...
  78. ncbi Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
    Anil Bagri
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:233-48. 2002
    ....
  79. ncbi Predictive neural coding of reward preference involves dissociable responses in human ventral midbrain and ventral striatum
    JOHN P O'DOHERTY
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuron 49:157-66. 2006
    ..These results provide insight into the neural mechanisms underlying human preference behavior...
  80. pmc Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro
    Sangmi Chung
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02178, USA
    Stem Cells 24:1583-93. 2006
    Neural precursors (NPs) derived from ventral mesencephalon (VM) normally generate dopaminergic (DA) neurons in vivo but lose their potential to differentiate into DA neurons during mitogenic expansion in vitro, hampering their efficient ..
  81. ncbi Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity
    H Kawasaki
    Department of Medical Embryology and Neurobiology, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Neuron 28:31-40. 2000
    ..Neural induction by SDIA provides a new powerful tool for both basic neuroscience research and therapeutic applications...
  82. pmc The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease
    Shane Grealish
    Wallenberg Neuroscience Centre, Lund University, Lund, Sweden
    Brain 133:482-95. 2010
    Grafts of foetal ventral mesencephalon, used in cell replacement therapy for Parkinson's disease, are known to contain a mix of dopamine neuronal subtypes including the A9 neurons of the substantia nigra and the A10 neurons of the ..
  83. ncbi Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    Glia 55:1178-88. 2007
    ..These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein...
  84. pmc Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals
    James P Dugan
    Department of Biology, University of Nevada, Reno, NV 89557, USA
    Mol Cell Neurosci 46:347-56. 2011
    Dopaminergic neurons from the ventral mesencephalon/diencephalon (mesodiencephalon) form vital pathways constituting the majority of the brain's dopamine systems...
  85. pmc Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells
    Vellareddy Anantharam
    Parkinson s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011 1250, USA
    Neurotoxicology 28:988-97. 2007
    ..This study supports a critical role of NADPH oxidase in the oxidative damage in PD; targeting this enzyme may lead to novel therapies for PD...
  86. ncbi Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells
    Yuichi Ono
    KAN Research Institute Inc, KobeMI R and D Center 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Development 134:3213-25. 2007
    ..Our data provide insights into the mechanisms of specification and generation of mesDA neurons, and illustrate a useful cell replacement approach for Parkinson's disease...
  87. pmc Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools
    Milan Joksimovic
    Northwestern University Feinberg School of Medicine, Department of Neurology and Center for Genetic Medicine, 7 113 Lurie Building, 303 East Superior Street, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:19185-90. 2009
    ..This refined ontogenetic definition will expand understanding of dopamine neuron biology and selective susceptibility, and will impact stem cell-derived therapies and models for PD...
  88. ncbi Anatomical distribution and cellular basis for high levels of aromatase activity in the brain of teleost fish: aromatase enzyme and mRNA expression identify glia as source
    P M Forlano
    Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
    J Neurosci 21:8943-55. 2001
    ....
  89. ncbi Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism
    P Sacchetti
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, USA
    J Neurochem 76:1565-72. 2001
    ..Additional experiments using a nurr1 mutant construct suggest that nurr1 activates hDAT transcription via a novel NBRE-independent mechanism...
  90. ncbi Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain
    Nina Rawal
    Laboratory of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 1, A1 2, 171 77 Stockholm, Sweden
    Exp Cell Res 312:1626-36. 2006
    ..Thus, our results show that Fzs are developmentally regulated and differentially expressed in VM precursors, DA neurons, and glia. These findings suggest that Fz expression contributes to provide specificity to Wnt-mediated effects...
  91. pmc Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons
    Mianzhi Tang
    VA Medical Center and Department of Pathology, University of California San Francisco, San Francisco, CA 94121, USA
    Development 136:2027-38. 2009
    ..They also suggest that beta-catenin-mediated signaling pathways can be targeted to promote and expand DA neurons in cell-based therapeutic strategies...
  92. ncbi Pedunculopontine tegmental nucleus controls conditioned responses of midbrain dopamine neurons in behaving rats
    Wei Xing Pan
    Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9001, New Zealand
    J Neurosci 25:4725-32. 2005
    ..We propose that the PPTg relays information about the precise timing of attended sensory events, which is integrated with information about reward context by DA neurons...
  93. pmc A developmental and genetic classification for midbrain-hindbrain malformations
    A James Barkovich
    Neuroradiology Room L371, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
    Brain 132:3199-230. 2009
    ..Importantly, both the classification and its framework remain flexible enough to be easily modified when new embryologic processes are described or new malformations discovered...
  94. ncbi Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease
    Todd B Sherer
    Center for Neurodegenerative Disease, Rollins School of Public Health, Atlanta, Georgia 15213, USA
    J Neurochem 100:1469-79. 2007
    ....
  95. pmc Short-latency visual input to the subthalamic nucleus is provided by the midbrain superior colliculus
    Veronique Coizet
    Department of Psychology, University of Sheffield, Sheffield S10 2TP, United Kingdom
    J Neurosci 29:5701-9. 2009
    ....
  96. ncbi Transplantation of embryonic dopamine neurons for severe Parkinson's disease
    C R Freed
    Division of Clinical Pharmacology, University of Colorado School of Medicine, Denver 80262, USA
    N Engl J Med 344:710-9. 2001
    ..CONCLUSIONS: Human embryonic dopamine-neuron transplants survive in patients with severe Parkinson's disease and result in some clinical benefit in younger but not in older patients...
  97. ncbi Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice
    A Wallen
    Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, S 171 77, Sweden
    Exp Cell Res 253:737-46. 1999
    ..We conclude that NURR1 plays a critical role in the maturation, migration, striatal target area innervation, and survival of differentiating mesencephalic DA cells...
  98. ncbi Identification of intrinsic determinants of midbrain dopamine neurons
    Elisabet Andersson
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    Cell 124:393-405. 2006
    ..These data establish that Lmx1a and Msx1 are critical intrinsic dopamine-neuron determinants in vivo and suggest that they may be essential tools in cell replacement strategies in Parkinson's disease...
  99. pmc Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons
    Xuefei Wu
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Int J Neuropsychopharmacol 11:1123-34. 2008
    ..This study indicates that astrocytes may be a critical neuroprotective mechanism of HDAC inhibitors, revealing a novel target for the treatment of psychiatric and neurodegenerative diseases...
  100. ncbi Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons
    Susan L Ingram
    Vollum Institute and Howard Hughes Medical Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA
    Nat Neurosci 5:971-8. 2002
    ..Thus, in addition to clearing extracellular DA, our results suggest that the currents associated with DAT modulate excitability and may regulate release of neurotransmitter from midbrain DA neurons...
  101. ncbi FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region
    Tomi Jukkola
    Institute of Biotechnology, Viikki Biocenter, P O Box 56, 00014 University of Helsinki, Finland
    Dev Biol 297:141-57. 2006
    ..Our results also show altered neurogenesis in the midbrain and R1 of the Fgfr1 mutants. Interestingly, the neuronal progenitors in midbrain and R1 show different responses to the loss of signaling through FGFR1...

Research Grants62

  1. TNF Signaling in Neurodegeneration
    MARIALOURDES G TANSEY; Fiscal Year: 2010
    ..mechanisms required for degeneration of DA neurons in rodent primary neuronal cultures of embryonic ventral mesencephalon (EVMCs)...
  2. Activation of GPR37 and GPR37L1 by prosaptide, a neuroprotective peptide
    Randy A Hall; Fiscal Year: 2013
    ..The signaling studies will focus on primary cultures of dopaminergic neurons from the ventral mesencephalon and cortical neurons, which preferentially express GPR37 vs. GPR37L1, respectively...
  3. Nigrostriatal Tract Reconstruction
    JOHN RICHARD SLADEK; Fiscal Year: 2010
    ..tested the ability of "helper" grafts to stimulate and guide the extension of neurites from grafts of ventral mesencephalon that contained dopaminergic neurons...
  4. The Synaptic Origin of Reward Prediction Error Signal in Dopaminergic Neurons
    CARLOS ANTONIO PALADINI; Fiscal Year: 2013
    ..neurons of the ventral tegmental area and substantia nigra pars compacta, located within the ventral mesencephalon, encode perhaps one of the most important signals for reinforcement learning in the brain: reward prediction ..
  5. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2005
    ..The factors being tested are expressed in the developing mesencephalon, diencephalon and telencephalon and are involved in GABAergic development...
  6. EYELID SENSORIMOTOR NETWORKS
    Mark leDoux; Fiscal Year: 2003
    ..been associated with structural lesions of the central nervous system, particularly the rostral brainstem and mesencephalon. Light sensitivity (photophobia) is a symptom with most patients...
  7. PRE & POSTSYNAPTIC NICOTINIC ACHRS--STRUCTURE & FUNCTION
    Peter Sargent; Fiscal Year: 1999
    ..of the nicotinic receptor gene products are available: the lateral spiriform nucleus (SpL), located in the mesencephalon, and the ciliary ganglion, located in the orbit...
  8. Roles of neurotrophic factors in dental pulp innervation
    Christopher Nosrat; Fiscal Year: 2003
    ..support for many different types of neurons in vitro including the dopaminergic neurons of the ventral mesencephalon. These neurons are lost in Parkinson's disease...
  9. GENETIC CONTROL OF MID-HIND BRAIN PATTERNING
    Alexandra Joyner; Fiscal Year: 1999
    ..goal of this project is to elucidate genetic pathways regulating early determination and development of the mesencephalon (midbrain) and metencephalon (cerebellum)...
  10. DOPAMINERGIC NEUROTROPHIC FACTORS AND TOURETTE SYNDROME
    MEG PALMATIER; Fiscal Year: 1999
    ..3. Further define the dopaminergic neurotrophic effects of ANPF on central nervous system ventral mesencephalon dopaminergic neurons. 4. If linkage is shown, pursue appropriate studies to clone and identify the gene for TS...
  11. Lineage & Development of the Midbrain & Hindbrain
    Mark Zervas; Fiscal Year: 2005
    ..The mesencephalon (mes) and metencephalon (met) are opposed to each other and are clearly distinct morphological structures...
  12. CATECHOLAMINERGIC NEURON PLASTICITY IN AGED BRAIN
    Carol Phelps; Fiscal Year: 1990
    ..severed, either near their point of termination at the SON, or near their cells of origin in the ventral mesencephalon. The lesion sites and the target nucleus, SON, will be examined for new fiber growth and CA reinnervation, ..
  13. Dendritic Role in Dopamine Neuron Firing
    Joseph Callaway; Fiscal Year: 2004
    Destruction or dysfunction of the dopaminergic neurons of the mesencephalon is believed to underlie a variety of disorders of movement, motivation and mentation, including Parkinson's disease, and schizophrenia...
  14. Fas (CD95)-induced regeneration of dopaminergic neurons
    Julie Desbarats; Fiscal Year: 2003
    ..use three models: tyrosine hydroxylase-positive (TH+) cell lines; in vitro cultures of embryonic mouse ventral mesencephalon cells enriched for TH+ neurons by flow cytometric sorting; and MPTP- induced nigrostriatal degeneration in the ..
  15. Cell Grafts for Parkinson's Disease
    Timothy Collier; Fiscal Year: 2004
    ..In an effort to accomplish this, single cells isolated from ventral mesencephalon were clonally expanded and exposed to hematopoeitic cytokines and neurotrophic molecules...
  16. SENSORIMOTOR INTEGRATION IN RED NUCLEUS NEURONS
    JAMES HOUK; Fiscal Year: 2000
    ..Most of the experiments will utilize horizontal slices through the mesencephalon of the turtle; this orientation preserves both ascending sensory and cerebellar afferents to the red nucleus...
  17. NEUREGULINS AND NIGROSTRIATAL SYSTEM FUNCTION
    Kim Seroogy; Fiscal Year: 2003
    ..1 will determine the extent to which neuregulin receptors are expressed by dopaminergic cells in the ventral mesencephalon of normal and neurotoxin-lesioned rat and monkey using single- and double-labeling in situ hybridization and ..
  18. Role of Gbx2 and Otx2 in the mes-met organizer function
    James Li; Fiscal Year: 2003
    The long-term goal of this proposal is to elucidate the molecular basis of patterning of the mesencephalon (midbrain) and metencephalon (cerebellum), jointly called mes-met...
  19. GENETIC BASIS OF MESENCEPHALIC/METENCEPHALIC PATTERNING
    Daniel Kessler; Fiscal Year: 2004
    ..Abstract): The long-term goal of this research is to understand the genetic basis of development in the mesencephalon (midbrain) and metencephalon (anterior hindbrain) region (MMR) of the brain...
  20. BRAIN MIDLINE MALFORMATION IN SCHIZOPHRENIA
    Curtis Deutsch; Fiscal Year: 2003
    ..junctural region implicated in schizophrenia corresponds to the interface of the diencephalon and mesencephalon. Based on our craniofacial findings, we predicted that brain maldevelopment in schizophrenia might arise at ..
  21. DENDRITIC CALCIUM AND TRANSMITTER RELEASE
    Joseph Callaway; Fiscal Year: 1999
    DESCRIPTION (from applicant's abstract) Destruction or dysfunction of the dopaminergic neurons of the mesencephalon is believed to underly a variety of disorders of movement, motivation and mentation, including Parkinson's disease, and ..
  22. MOLECULAR MECHANISMS OF COCAINE SENSITIZATION
    BARBARA SORG; Fiscal Year: 1993
    ..This system consists of dopamine cell bodies located in the A10 region of the ventromedial mesencephalon and their projections to the nucleus accumbens...
  23. Analysis of nurr1 isoforms in rat ventral midbrain
    SHARON MICHELHAUGH; Fiscal Year: 2006
    ..In Aim 1 of this proposal, the nurr1 isoform expression profile will be defined in rat ventral mesencephalon (substantia nigra and ventral tegmentum) and all identified forms will be cloned...
  24. CNS GRAFTING FOR PARKINSONISM
    Roy Bakay; Fiscal Year: 1999
    ..of dopaminergc neurons, but also the fate of GABAergic neurons which also are concentrated in the ventral mesencephalon. Using a technique we are developing, all grafted cells can be identified...
  25. BIOMEDICAL RESEARCH SUPPORT
    LEON HOYER; Fiscal Year: 1991
    ..tyrosine hydroxylase levels and intracellular Ca++ in cultured dopaminergic neurons from embryonic rat mesencephalon. (4) Dr...
  26. CATECHOLAMINE UNIT ACTIVITY AND POSITIVE REINFORCERS
    DWIGHT GERMAN; Fiscal Year: 1980
    ..Single unit activity is recorded from the DA cells in the ventral mesencephalon, and the NE cells of the locus coeruleus, and correlated with operant responding for a natural reward (i.e...
  27. Prenatal LPS-induced changes in gene expression
    Paul Carvey; Fiscal Year: 2005
    ..ELISA) content for TNF-a, interleukin (IL) -113, IL-6, transforming growth factor (TGFbeta), and IL-6 in the mesencephalon, striatum, and cerebellum (control region) to determine if prenatal LPS alters transcriptional and ..
  28. NEUROETHOLOGY OF VOCAL COMMUNICATION
    Andrea Simmons; Fiscal Year: 2006
    ..abstract_text> ..
  29. ENERGY METABOLISM, DOPAMINE NEURONS AND NEUROTOXICITY
    Gail Zeevalk; Fiscal Year: 2008
    ..The studies will have relevance to neurodegenerative conditions or pathophysiological situations in which metabolism is compromised. ..
  30. RESULT OF MODALITY CONVERGENCE IN THE BRAIN
    Barry Stein; Fiscal Year: 2005
    ....
  31. TRAINING PROGRAM IN HEARING AND MULTISENSORY INTEGRATION
    Barry Stein; Fiscal Year: 2007
    ..A major focus for the training program continues to be the recruitment of under represented minorities. [unreadable] [unreadable]..
  32. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
  33. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  34. LPH to VTA Neurotensin: Actions and Cocaine Effects
    DANIEL ZAHM; Fiscal Year: 2004
    ..The data may lead to better, more selective therapeutic approaches to prevention of psychostimulant sensitization, which is thought play a significant role in destructive drug seeking behaviors. ..
  35. Form/function of Extended Amygdala/Accumbens Shell:CRF
    DANIEL ZAHM; Fiscal Year: 2005
    ....
  36. ENCODING OF VOCAL SIGNALS IN THE AUDITORY SYSTEM
    Andrew H Bass; Fiscal Year: 2011
    ..with auditory; neuropathy/dys-synchrony.. '-.'...... ..
  37. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. [unreadable] [unreadable] [unreadable]..
  38. Lateral Hypothalamus, Dopamine and Ingestive Behavior
    David Wirtshafter; Fiscal Year: 2007
    ..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
  39. Northeast Under/Grad Research Organization for Neuroscience
    Cheryl Frye; Fiscal Year: 2008
    ..Both of these outcomes are congruous with the Public Health Service's mission to ensure that there is a resource of well-trained scientists and health-care providers in the United States. [unreadable] [unreadable] [unreadable]..
  40. Perioculomotor area and alcohol
    Andrey E Ryabinin; Fiscal Year: 2010
    ..These studies will provide novel important information indicating how these recently identified neurons robustly regulate alcohol intake. ..
  41. Stem Cell Adaptability in Parkinson' Disease
    DAVID YUREK; Fiscal Year: 2009
    ..The variable of host age on ESC-derived dopamine neuron adaptability will be studied. ..
  42. GDNF Delivery to MPTP Monkeys by EIAV lentivirus and AAV
    DONALD REDMOND; Fiscal Year: 2008
    ..These studies aim to provide the necessary data to initiate successful clinical trials in Parkinson's patients at the earliest possible time. ..
  43. Pitx2 Function in Developing Mouse Brain Neurons
    Donna M Martin; Fiscal Year: 2010
    ..These results will help guide future experiments aimed at directing neural stem cell differentiation toward specific neuronal cell subtypes. ..
  44. NEUROPROTECTIVE STRATEGIES AGAINST OXIDATIVE DAMAGE
    Anumantha Kanthasamy; Fiscal Year: 2009
    ....
  45. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2009
    ....
  46. Improving neural graft function in parkinsonian monkeys.
    DONALD REDMOND; Fiscal Year: 2007
    ..abstract_text> ..
  47. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  48. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
    ..abstract_text> ..
  49. SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESS
    MICHAEL KENNEY; Fiscal Year: 2004
    ..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
  50. Acoustic Interference on Attention in HIV Patients
    Dardo Tomasi; Fiscal Year: 2003
    ..More generally, this study will also improve the understanding of the neural effects of acoustic noise interference during fMRI studies in healthy populations. ..
  51. EX VIVO ANGIOGENIC GENE TRANSFER IN NEURAL TRANSPLANTS
    Diana Casper; Fiscal Year: 2002
    ..from the specific degeneration of dopaminergic neurons in the pars compacta of the substantia nigra of the mesencephalon. The relatively new strategy of neuronal transplantation has provided encouraging results for Parkinson's ..
  52. PERIAQUEDUCTAL GRAY MODULATION OF SYMPATHETIC DRIVE
    Linda Hayward; Fiscal Year: 2002
    ..In the long term it is hoped that the results of these studies will stimulate new investigations into the role of the dlPAG, A5 and the PBN in normal and pathophysiological cardiovascular regulation. ..
  53. NEUROTROPHIN CONTROL OF REM SLEEP
    Jack Yamuy; Fiscal Year: 2004
    ..This concerted set of experiments will be critical in elucidating the role that neurotrophins play in the control of REM sleep. ..
  54. Gene Therapy, Neural Grafts & Parkinson's Disease
    DAVID YUREK; Fiscal Year: 2005
    ..These studies will also determine if combinations of viral vectors expressing different neurotrophic factors can be used to improve the therapeutic effects of dopamine grafts. ..
  55. Sympathetic-Immune Interface: Central Sites & Function
    MICHAEL KENNEY; Fiscal Year: 2005
    ..Ultimately, these findings may allow for the design of intervention strategies in immune regulation fostering robust and appropriate communication between the immune and nervous systems. ..
  56. NEUROANATOMICAL SUBSTRATES OF ALCOHOL-INDUCED AMNESIA
    Andrey Ryabinin; Fiscal Year: 2001
    ..Taken together, these studies will provide valuable insight at several levels of analysis of alcohol~s action on cognitive functions and eventually allow to start understanding of the mechanisms involved in alcohol-induced amnesia. ..
  57. Role of Pitx2 in the Mammalian Central Nervous System
    Donna Martin; Fiscal Year: 2005
    ..in the developing neuroepithelial ventricular zone, in radially migrating cells, and in the mature cortex, mesencephalon, and diencephalon [72, 101]...
  58. PREOPTIC AREA AND PHARMACOLOGIC SLEEP INDUCTION
    Paul Vezina; Fiscal Year: 2001
    ....
  59. CASPASES, MITOCHONDRIAL FUNCTION AND PARKINSON'S DISEASE
    Anumantha Kanthasamy; Fiscal Year: 2006
    ..abstract_text> ..
  60. Pulsed magnetic fields, neurons, and blood vessels
    Diana Casper; Fiscal Year: 2006
    ..Results could have applications not only in therapeutic strategies for Parkinson's disease, but in the treatment of other chronic and acute vascular and neurodegenerative diseases. ..
  61. Supramedullary control of respiration
    Linda Hayward; Fiscal Year: 2007
    ..Furthermore, the results of this study will provide new insights into understanding of the role of supramedullary structures in modulating respiratory timing. [unreadable] [unreadable]..
  62. BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSION
    David Wirtshafter; Fiscal Year: 2003
    ..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..