- Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
Jong Hoon Kim
Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 418:50-6. 2002
..The dopamine neurons generated by these stem cells show electrophysiological and behavioural properties expected of neurons from the midbrain. Our results encourage the use of ES cells in cell-replacement therapy for Parkinson's disease...
- The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
Laboratory of Molecular Neuroendocrinology, Zentrum fur Molekulare Biologie, University of Heidelberg, Germany
J Neurosci 12:1040-62. 1992
..Based on significant mismatches between alpha 4/delta and gamma mRNAs, we suggest that in vivo, the alpha 4 subunit contributes to GABAA receptors that lack BZ modulation...
- Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
J Clin Invest 116:3229-39. 2006
..Taken together, these data suggest that the mesolimbic reward circuitry is targeted by peripheral ghrelin to influence physiological mechanisms related to feeding...
- Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat
R G Nair-Roberts
Department of Zoology, University of Oxford, South Parks Rd, Oxford, OX1 3PS, UK Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3US, UK
Neuroscience 152:1024-31. 2008
- Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
Department of Cell Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 95:4013-8. 1998
..Taken together, these data indicate that Nurr1 is essential for both survival and final differentiation of ventral mesencephalic late dopaminergic precursor neurons into a complete dopaminergic phenotype...
- Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Pharmacol Exp Ther 293:607-17. 2000
- Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, NY 10016, USA
Development 133:1799-809. 2006
..Thus, the precise spatial and temporal regulation of Gli2A and Gli3R by Shh is instrumental in coordinating mid/hindbrain development in three dimensions...
- Genetic networks controlling the development of midbrain dopaminergic neurons
GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstr 1, D 85764 Munich Neuherberg, Germany
J Physiol 575:403-10. 2006
..We will summarize these new findings in the overall context of midbrain dopaminergic neuron development in this review...
- The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
Candace L Chi
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
Development 130:2633-44. 2003
..and cerebellum develop from a region of the early neural tube comprising two distinct territories known as the mesencephalon (mes) and rostral metencephalon (met; rhombomere 1), respectively...
- Neural plate patterning: upstream and downstream of the isthmic organizer
Institute of Mammalian Genetics, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
Nat Rev Neurosci 2:99-108. 2001
..Here we review our current knowledge on the identity, localization and maintenance of the isthmic organizer, as well as on the molecular cascades that underlie the activity of this organizing centre...
- Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon
Queensland Brain Institute, University of Queensland, QLD 4072, Australia
Neurosci Lett 486:220-3. 2010
..to examine the expression of genes important for dopaminergic development and maturation within the embryonic mesencephalon using an epidemiologically-informed animal model of schizophrenia, the developmental vitamin D (DVD) deficient ..
- Derivation of midbrain dopamine neurons from human embryonic stem cells
Anselme L Perrier
Laboratory of Stem Cell and Tumor Biology, Division of Neurosurgery and Developmental Biology Program, and Cell Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
Proc Natl Acad Sci U S A 101:12543-8. 2004
..This experimental system also provides a powerful tool to probe the molecular mechanisms that control the development and function of human midbrain DA neurons...
- Reward-related FMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation
Bianca C Wittmann
Department of Neurology II and, Centre for Advanced Imaging, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
Neuron 45:459-67. 2005
..These data are consistent with the hypothesis that activation of dopaminergic midbrain regions enhances hippocampus-dependent memory formation, possibly by enhancing consolidation...
- Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
K R Thomas
Howard Hughes Medical Institute, Department of Biology and Human Genetics, Salt Lake City, Utah 84112
Nature 346:847-50. 1990
..int-1-/int-1- mice at several stages of embryogenesis revealed severe abnormalities in the development of the mesencephalon and metencephalon indicating a prominent role for the int-1 protein is in the induction of the mesencephalon ..
- Regionally specified human neural progenitor cells derived from the mesencephalon and forebrain undergo increased neurogenesis following overexpression of ASCL1
Hyun Jung Kim
Department of Anatomy, University of Wisconsin Madison, Madison, Wisconsin, USA
Stem Cells 27:390-8. 2009
..Although this restores neuronal production with a region-specific phenotype, it does not restore full neurochemical maturation, which may require additional factors...
- Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice
Clare L Parish
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
J Clin Invest 118:149-60. 2008
- Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Development 128:1253-64. 2001
..Our results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development...
- Roles of subthreshold calcium current and sodium current in spontaneous firing of mouse midbrain dopamine neurons
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 27:645-56. 2007
..The results also show a significant contribution of subthreshold TTX-sensitive sodium current...
- Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
FASEB J 19:533-42. 2005
..Finally, NADPH oxidase could be an ideal target for potential pharmaceutical intervention, given that it plays a critical role in alpha-synuclein-mediated microglial activation and associated neurotoxicity...
- Dopaminergic transplantation for Parkinson's disease: current status and future prospects
C Warren Olanow
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
Ann Neurol 66:591-6. 2009
..have failed to meet their primary endpoints, and transplantation of dopamine cells derived from the fetal mesencephalon is associated with a potentially disabling form of dyskinesia that persists even after withdrawal of levodopa (..
- Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon
CEINGE Biotecnologie Avanzate, Via Comunale Margherita 482, 80145 Naples, Italy
Development 135:3459-70. 2008
..Otx2 is required for the establishment of the mesencephalic field and molecular code of the entire ventral mesencephalon (VM)...
- GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
L F Lin
Synergen, Inc, Boulder, CO 80301
Science 260:1130-2. 1993
..GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons...
- Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Neurosci 30:9280-91. 2010
..Persistent activation of beta-catenin in early progenitors perturbs their cell cycle progression and antagonizes Shh expression, whereas activation of beta-catenin in midline progenitors promotes the generation of dopamine neurons...
- Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
Laboratory of Molecular Neurobiology, Medical Biochemistry, and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 100:12747-52. 2003
..These findings indicate that Wnts are key regulators of proliferation and differentiation of DA precursors during VM neurogenesis and that different Wnts have specific and unique activity profiles...
- Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis
Northwestern University Feinberg Medical School, Department of Neurology and Center for Genetic Medicine, 7 113 Lurie Bldg, 303 E Superior Street, Chicago, Illinois 60611, USA
Nat Neurosci 12:125-31. 2009
..These findings demonstrate how the dynamic interplay of canonical Wnt/beta-catenin signaling and Shh may orchestrate floor plate neurogenesis or a lack thereof...
- Modulation power and phase spectrum of natural sounds enhance neural encoding performed by single auditory neurons
Neuroscience Institute and Department of Physics, University of California, Berkeley, Berkeley, California 94720 1650, USA
J Neurosci 24:9201-11. 2004
..We found that rate distribution and bandwidth but not reliability were responsible for the higher average information rates found for song-like sounds...
- Development of dopaminergic neurons in the mammalian brain
GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstr 1, 85764 Munich Neuherberg, Germany
Cell Mol Life Sci 63:187-206. 2006
..In the present review, we provide an overview of the mechanisms and factors involved in the development of dopaminergic neurons in the mammalian brain, with a special emphasis on the midbrain dopaminergic population...
- Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway
Department of Psychiatry and Program in Neuroscience, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
Cell Stem Cell 5:646-58. 2009
..Together with previous works, this study shows that two regulatory loops (Wnt1-Lmx1a and SHH-FoxA2) critically link extrinsic signals to cell-intrinsic factors and cooperatively regulate mDA neuron development...
- Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons
Ludwig Institute for Cancer Research, Stockholm Branch, SE 171 77 Stockholm, Sweden
J Neurosci 29:15923-32. 2009
- Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells
Ludwig Institute for Cancer Research, Stockholm Branch, P O Box 240, S 171 77 Stockholm, Sweden
Exp Cell Res 288:324-34. 2003
..Together, the results provide evidence indicating an instructive role for Nurr1 in controlling DA synthesis and storage...
- Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Neural Dev 6:29. 2011
..Given these dynamic gene expression patterns, Shh and Gli1 expression could delineate different progenitor populations at distinct embryonic time points...
- Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner
Anna L M Ferri
Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 134:2761-9. 2007
..Altogether, our results demonstrate that Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner...
- Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells
The Ludwig Institute for Cancer Research, Karolinska Institutet, 17177 Stockholm, Sweden
Proc Natl Acad Sci U S A 106:7613-8. 2009
..Thus, the enriched generation of functional mesDA neurons by forced expression of Lmx1a may be of future importance in cell replacement therapy of Parkinson disease...
- Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region
Institute of Developmental Genetics, GSF Research Center for Environment and Health, 85764 Neuherberg, Germany
Mol Cell Neurosci 26:101-11. 2004
..We suggest that Wnt1 acts as a regulator of proliferation of specific precursor populations in the developing mid-/hindbrain region and is only secondarily involved in maintenance of the mid-/hindbrain organizer...
- The dual dopamine-glutamate phenotype of growing mesencephalic neurons regresses in mature rat brain
Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
J Comp Neurol 517:873-91. 2009
..These results suggest a regression of the VGLUT2 phenotype of dopamine neurons with age, following normal development, lesion, or sprouting after injury, and a role for glutamate in the establishment of synapses by these neurons...
- Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals
Jeremy J Clark
Department of Psychiatry and Behavioral Sciences and Department of Pharmacology, University of Washington, Seattle, Washington, USA
Nat Methods 7:126-9. 2010
..Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice...
- Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation
International Institute of Genetics and Biophysics CNR, Naples, Italy
Development 121:3279-90. 1995
- Dissecting the diversity of midbrain dopamine neurons
Institute of Neurophysiology, Neuroscience Center, Goethe University, Frankfurt, Germany
Trends Neurosci 36:336-42. 2013
- Transcranial sonography in movement disorders
Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
Lancet Neurol 7:1044-55. 2008
..Thus, this neuroimaging method could be recommended for general application in the diagnosis and differential diagnosis of PD...
- Specification of the meso-isthmo-cerebellar region: the Otx2/Gbx2 boundary
INSERM U106, Hopital de la Salpetriere, Pavillon Enfants et Adolescents, 75651 Paris Cedex 13, France
Brain Res Brain Res Rev 49:134-49. 2005
..Otx2 and Gbx2 co-regulation could determine the precise location of the MH boundary and involved in the inductive events characteristic of the isthmic organizer center...
- Morphology and connections of nucleus isthmi pars magnocellularis in chicks (Gallus gallus)
Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
J Comp Neurol 469:275-97. 2004
..The laminar and columnar pattern of isthmotectal terminals also suggests a means of interacting with multiple tectofugal pathways, including the stratified subpopulations of tectorotundal neurons participating in motion detection...
- Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures
Institute of Chemistry and Biochemistry, Department for Biomedical Sciences, University for Veterinary Medicine, Veterinaerplatz 1, A 1210 Vienna, Austria
Phytomedicine 19:819-24. 2012
..Even though no significant preservation or recovery of neurite outgrowth to control values could be observed, our data show that cannabinoids THC and THCA protect dopaminergic neurons against MPP(+) induced cell death...
- A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging
Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
J Neurosci 25:7333-41. 2005
..05, Pearson's r, two-tailed) but not somatic stimulation. We propose that the differences in NCF and right PAG activation observed may represent a greater nocifensive response and greater emotive salience of visceral over somatic pain...
- Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon
KAN Research Institute Inc, Kobe MI R and D Center, 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
Dev Biol 339:101-13. 2010
..We also found that, in the mesencephalon, FP cell fate is primarily determined by Foxa2 with a supportive action of Lmx1a/b through repressing Nkx6...
- Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity
Yannis E Mavromatakis
Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Mech Dev 128:90-103. 2011
..Altogether, these data indicate that Foxa1 and Foxa2 contribute to the specification of ventral midbrain progenitor identity by regulating Shh signalling in a positive and negative manner...
- Effect of GDNF on differentiation of cultured ventral mesencephalic dopaminergic and non-dopaminergic calretinin-expressing neurons
Department of Neurosurgery, University of Bern, CH 3010 Bern, Switzerland
Brain Res 1036:163-72. 2005
..These cells were identified as GABA-expressing neurons. In conclusion, our findings recognize GDNF as a potent differentiation factor for the development of VM dopaminergic and non-dopaminergic CR-expressing neurons...
- Reciprocal inhibition of inhibition: a circuit motif for flexible categorization in stimulus selection
Shreesh P Mysore
Department of Neurobiology, Stanford University, 299 W Campus Drive, Stanford, CA 94305, USA
Neuron 73:193-205. 2012
..The results demonstrate the extraordinary power of a remarkably simple, neurally grounded circuit motif in producing flexible categorization, a computation fundamental to attention, perception, and decision making...
- Specification of dorsoventral polarity in the embryonic chick mesencephalon and its presumptive role in midbrain morphogenesis
JRG Developmental Neurobiology, Biocentre, University of Wuerzburg, Wuerzburg, Germany
Dev Dyn 233:907-20. 2005
- Characterizing the mesencephalon using susceptibility-weighted imaging
E S Manova
Department of Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA
AJNR Am J Neuroradiol 30:569-74. 2009
The mesencephalon is involved in a number of human neurodegenerative disorders and has been typically imaged with T1-, T2- and T2*-weighted methods...
- Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson's disease
E M Torres
Department of Biosciences, Biomedical Sciences Building, Museum Avenue, Cardiff University, PO Box 911 Cardiff South Glamorgan, UK
Neuroscience 154:631-40. 2008
- Dopamine neuron agenesis in Nurr1-deficient mice
R H Zetterström
Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
Science 276:248-50. 1997
..These results suggest that putative Nurr1 ligands may be useful for treatment of Parkinson's disease and other disorders of midbrain dopamine circuitry...
- Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells
MRC Clinical Sciences Centre, Imperial College London, UK
Mol Brain 1:8. 2008
..involved in the development of mDA neurons, including the induction of mDA neuron progenitors in the ventral mesencephalon, the specification of the mDA neuronal fate and the maintenance of postmitotic mDA neurons...
- Establishment of an immortalized GABAergic neuronal progenitor cell line from embryonic ventral mesencephalon in the rat
Beijing Institute for Neuroscience, Capital Medical University, Beijing Center of Neural Regeneration and Repair, Key Laboratory of Neurodegenerative diseases of Ministry of Education of China, Beijing 100069, China
Brain Res 1210:63-75. 2008
..controlled immortalized GABAergic neuronal progenitor cell line (RMNE6) was established from E13 rat ventral mesencephalon cells immortalized using the temperature-sensitive mutant of SV40 large T antigen (ts-TAg)...
- The dopaminergic mesencephalic projections to the hippocampal formation in the rat
Department of Sciences and Biomedical Technologies, University of L Aquila, Italy
Prog Neuropsychopharmacol Biol Psychiatry 21:1-22. 1997
..The functional significance of the mesohippocampal dopaminergic system is largely unknown, although it was suggested that this projection could have a role in methamphetamine-produced hypermotility and in modulation of memory processes...
- Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
Hui Ming Gao
Neuropharmacology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Neurosci 22:782-90. 2002
..Using primary neuron-enriched and neuron/glia cultures from the rat mesencephalon, we discovered an extraordinary feature for rotenone-induced degeneration of cultured dopaminergic neurons...
- Anesthetic state modulates excitability but not spectral tuning or neural discrimination in single auditory midbrain neurons
Joseph W Schumacher
Doctoral Program in Neurobiology and Behavior, Columbia University, New York, NY 10027, USA
J Neurophysiol 106:500-14. 2011
- Improved survival of young donor age dopamine grafts in a rat model of Parkinson's disease
E M Torres
Department of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff CF10 3US, UK
Neuroscience 146:1606-17. 2007
..We consider the in vivo conditions which allow this differentiation to occur, and the implications for the future of clinical trials based on dopamine cell replacement therapy...
- Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect
Institute of Developmental Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, and Technical University Munich, Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Munich Neuherberg, Germany
Dev Dyn 239:246-60. 2010
..Fzd3 and Fzd6 thus control proper midbrain morphogenesis by a yet unknown mechanism in the mouse...
- Migration of dopaminergic neurons in the embryonic mesencephalon of mice
Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan
Brain Res Dev Brain Res 86:101-13. 1995
..Migration of dopamine (DA)-containing neurons and its guiding cues were histologically examined in the embryonic mesencephalon of normal mice...
- Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
Research Institute of Molecular Pathology, Vienna, Austria
Cell 79:901-12. 1994
..These data define a key role for Pax5 in early B lymphopoiesis and midbrain patterning...
- Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons
Dong Youn Hwang
Molecular Neurobiology Laboratory, McLean Hospital and Harvard Medical School, Belmont, MA, USA
J Neurochem 111:1202-12. 2009
- Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+ sensitivity of SK channels
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Eur J Neurosci 29:1883-95. 2009
- A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo
Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 129:4807-19. 2002
- Towards stem cell replacement therapies for Parkinson's disease
Laboratory of Molecular Neurobiology, MBB, Center for Developmental Biology and Regenerative Medicine, Scheelevagen 1, 17177 Stockholm, Sweden
Biochem Biophys Res Commun 396:152-6. 2010
- Transient high-frequency firing in a coupled-oscillator model of the mesencephalic dopaminergic neuron
Alexey S Kuznetsov
Center for BioDynamics and Mathematics Department, Boston University, Boston, Massachusetts, USA
J Neurophysiol 95:932-47. 2006
- Semaphorins 3A, 3C, and 3F in mesencephalic dopaminergic axon pathfinding
Hebert L Hernandez-Montiel
Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico
J Comp Neurol 506:387-97. 2008
..These results suggest that semaphorins may help to establish the dopaminergic projection from the midbrain to the striatum during embryonic development...
- Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors
Carol H Yan
Department of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
J Neurosci 31:12413-25. 2011
..Together, our results demonstrate that Lmx1a and Lmx1b function cooperatively to regulate proliferation, specification, and differentiation of mDA progenitors, including their floor plate-like properties...
- Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain
Daniel A Berg
Karolinska Institute, Department for Cell and Molecular Biology, Stockholm 17177, Sweden
Development 137:4127-34. 2010
..This strategy identified hedgehog signalling as a key component of adult dopamine neuron regeneration. These data show that brain regeneration can occur by activation of neurogenesis in quiescent brain regions...
- Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain
MRC Centre for Developmental Neurobiology, New Hunt s House, 4th Floor, King s College London, Guy s Campus, London Bridge, London SE1 1UL, UK
Development 131:2037-48. 2004
- Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
Marten P Smidt
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Development 131:1145-55. 2004
..However, an overall lower activity was observed. The results suggest that Pitx3 is specifically required for the formation of the SNc subfield at the onset of dopaminergic neuron differentiation...
- Functional groups in the avian auditory system
Sarah M N Woolley
Department of Psychology, Columbia University, New York, New York 10027, USA
J Neurosci 29:2780-93. 2009
..Comparing STRFs in midbrain and forebrain neurons suggested that both inheritance and emergence of tuning properties occur as information ascends the auditory processing stream...
- Particular subpopulations of midbrain and hypothalamic dopamine neurons express vesicular glutamate transporter 2 in the rat brain
Laboratory of Neuroendocrinology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
J Comp Neurol 498:581-92. 2006
..These results indicate that VGLUT2 is expressed in subsets of A10 and A11 dopamine neurons, which might release dopamine and glutamate separately from different varicosities in the majority of their single axons...
- Discrete coding of reward probability and uncertainty by dopamine neurons
Christopher D Fiorillo
Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
Science 299:1898-902. 2003
..The coding of uncertainty suggests a possible role for dopamine signals in attention-based learning and risk-taking behavior...
- Vitamin D(3) attenuates 6-hydroxydopamine-induced neurotoxicity in rats
J Y Wang
Department of Physiology, National Defense Medical Center, Taipei, Taiwan
Brain Res 904:67-75. 2001
..Since both H(2)O(2) and 6-OHDA may injure cells via free radical and reactive oxygen species, the neuroprotection seen here may operate via a reversal of such a toxic mechanism...
- Oxidative inactivation of mitochondrial aconitase results in iron and H2O2-mediated neurotoxicity in rat primary mesencephalic cultures
Neuroscience Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
PLoS ONE 4:e7095. 2009
..The goal of this study was to determine if oxidative inactivation of mitochondrial aconitase (m-aconitase) resulted in the release of redox-active iron (Fe2+) and hydrogen peroxide (H2O2) and whether this contributes to cell death...
- Nonlinear spectrotemporal sound analysis by neurons in the auditory midbrain
Monty A Escabi
W M Keck Center for Integrative Neuroscience and University of California San Francisco University of California Berkeley Joint Bioengineering Graduate Group, University of California, San Francisco, California 94143, USA
J Neurosci 22:4114-31. 2002
..Our findings delineate rules for spectrotemporal integration in the ICC that cannot be accounted for by conventional linear-energy integration models...
- FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F
Laboratory of Neuroscience, Graduate School of Frontier Biosciences, Osaka University, Suita 565 0871, Japan
J Neurosci 29:4044-55. 2009
..These results indicate that the MHB signaling center regulates the growth polarity of mDAN axons along the RC axis by inducing sema3F...
- Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
Department of Anatomy, Howard Hughes Medical Institute, CA, USA
Neuron 33:233-48. 2002
- Predictive neural coding of reward preference involves dissociable responses in human ventral midbrain and ventral striatum
JOHN P O'DOHERTY
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
Neuron 49:157-66. 2006
..These results provide insight into the neural mechanisms underlying human preference behavior...
- Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro
Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02178, USA
Stem Cells 24:1583-93. 2006
Neural precursors (NPs) derived from ventral mesencephalon (VM) normally generate dopaminergic (DA) neurons in vivo but lose their potential to differentiate into DA neurons during mitogenic expansion in vitro, hampering their efficient ..
- Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity
Department of Medical Embryology and Neurobiology, Institute for Frontier Medical Sciences, Kyoto University, Japan
Neuron 28:31-40. 2000
..Neural induction by SDIA provides a new powerful tool for both basic neuroscience research and therapeutic applications...
- The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease
Wallenberg Neuroscience Centre, Lund University, Lund, Sweden
Brain 133:482-95. 2010
Grafts of foetal ventral mesencephalon, used in cell replacement therapy for Parkinson's disease, are known to contain a mix of dopamine neuronal subtypes including the A9 neurons of the substantia nigra and the A10 neurons of the ..
- Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
Glia 55:1178-88. 2007
..These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein...
- Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals
James P Dugan
Department of Biology, University of Nevada, Reno, NV 89557, USA
Mol Cell Neurosci 46:347-56. 2011
Dopaminergic neurons from the ventral mesencephalon/diencephalon (mesodiencephalon) form vital pathways constituting the majority of the brain's dopamine systems...
- Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells
Parkinson s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011 1250, USA
Neurotoxicology 28:988-97. 2007
..This study supports a critical role of NADPH oxidase in the oxidative damage in PD; targeting this enzyme may lead to novel therapies for PD...
- Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells
KAN Research Institute Inc, KobeMI R and D Center 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
Development 134:3213-25. 2007
..Our data provide insights into the mechanisms of specification and generation of mesDA neurons, and illustrate a useful cell replacement approach for Parkinson's disease...
- Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools
Northwestern University Feinberg School of Medicine, Department of Neurology and Center for Genetic Medicine, 7 113 Lurie Building, 303 East Superior Street, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 106:19185-90. 2009
..This refined ontogenetic definition will expand understanding of dopamine neuron biology and selective susceptibility, and will impact stem cell-derived therapies and models for PD...
- Anatomical distribution and cellular basis for high levels of aromatase activity in the brain of teleost fish: aromatase enzyme and mRNA expression identify glia as source
P M Forlano
Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
J Neurosci 21:8943-55. 2001
- Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism
Department of Psychiatry, Wayne State University School of Medicine, Detroit, USA
J Neurochem 76:1565-72. 2001
..Additional experiments using a nurr1 mutant construct suggest that nurr1 activates hDAT transcription via a novel NBRE-independent mechanism...
- Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain
Laboratory of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 1, A1 2, 171 77 Stockholm, Sweden
Exp Cell Res 312:1626-36. 2006
..Thus, our results show that Fzs are developmentally regulated and differentially expressed in VM precursors, DA neurons, and glia. These findings suggest that Fz expression contributes to provide specificity to Wnt-mediated effects...
- Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons
VA Medical Center and Department of Pathology, University of California San Francisco, San Francisco, CA 94121, USA
Development 136:2027-38. 2009
..They also suggest that beta-catenin-mediated signaling pathways can be targeted to promote and expand DA neurons in cell-based therapeutic strategies...
- Pedunculopontine tegmental nucleus controls conditioned responses of midbrain dopamine neurons in behaving rats
Wei Xing Pan
Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9001, New Zealand
J Neurosci 25:4725-32. 2005
..We propose that the PPTg relays information about the precise timing of attended sensory events, which is integrated with information about reward context by DA neurons...
- A developmental and genetic classification for midbrain-hindbrain malformations
A James Barkovich
Neuroradiology Room L371, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
Brain 132:3199-230. 2009
..Importantly, both the classification and its framework remain flexible enough to be easily modified when new embryologic processes are described or new malformations discovered...
- Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease
Todd B Sherer
Center for Neurodegenerative Disease, Rollins School of Public Health, Atlanta, Georgia 15213, USA
J Neurochem 100:1469-79. 2007
- Short-latency visual input to the subthalamic nucleus is provided by the midbrain superior colliculus
Department of Psychology, University of Sheffield, Sheffield S10 2TP, United Kingdom
J Neurosci 29:5701-9. 2009
- Transplantation of embryonic dopamine neurons for severe Parkinson's disease
C R Freed
Division of Clinical Pharmacology, University of Colorado School of Medicine, Denver 80262, USA
N Engl J Med 344:710-9. 2001
..CONCLUSIONS: Human embryonic dopamine-neuron transplants survive in patients with severe Parkinson's disease and result in some clinical benefit in younger but not in older patients...
- Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice
Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, S 171 77, Sweden
Exp Cell Res 253:737-46. 1999
..We conclude that NURR1 plays a critical role in the maturation, migration, striatal target area innervation, and survival of differentiating mesencephalic DA cells...
- Identification of intrinsic determinants of midbrain dopamine neurons
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
Cell 124:393-405. 2006
..These data establish that Lmx1a and Msx1 are critical intrinsic dopamine-neuron determinants in vivo and suggest that they may be essential tools in cell replacement strategies in Parkinson's disease...
- Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
Int J Neuropsychopharmacol 11:1123-34. 2008
..This study indicates that astrocytes may be a critical neuroprotective mechanism of HDAC inhibitors, revealing a novel target for the treatment of psychiatric and neurodegenerative diseases...
- Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons
Susan L Ingram
Vollum Institute and Howard Hughes Medical Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA
Nat Neurosci 5:971-8. 2002
..Thus, in addition to clearing extracellular DA, our results suggest that the currents associated with DAT modulate excitability and may regulate release of neurotransmitter from midbrain DA neurons...
- FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region
Institute of Biotechnology, Viikki Biocenter, P O Box 56, 00014 University of Helsinki, Finland
Dev Biol 297:141-57. 2006
..Our results also show altered neurogenesis in the midbrain and R1 of the Fgfr1 mutants. Interestingly, the neuronal progenitors in midbrain and R1 show different responses to the loss of signaling through FGFR1...