Genomes and Genes
Summary: The part of the brain that connects the cerebral hemispheres with the spinal cord. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
Publications351 found, 100 shown here
- Astrocytes control breathing through pH-dependent release of ATPAlexander V Gourine
Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, UK
Science 329:571-5. 2010..This demonstrates a potentially crucial role for brain glial cells in mediating a fundamental physiological reflex...
- Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging modelAnn E Kingsbury
Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London, United Kingdom
Mov Disord 25:2508-15. 2010The lower brain stem of 25 pathologically-confirmed Parkinson's disease (PD) cases was examined by alpha synuclein immunohistochemistry to characterize pathological accumulation of alpha synuclein (Lewy-type α-synucleinopathy, LTS) in ..
- Comparative brain stem lesions on MRI of acute disseminated encephalomyelitis, neuromyelitis optica, and multiple sclerosisZhengqi Lu
Department of Neurology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
PLoS ONE 6:e22766. 2011b>Brain stem lesions are common in patients with acute disseminated encephalomyelitis (ADEM), neuromyelitis optica (NMO), and multiple sclerosis (MS).
- Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndromeL Medrihan
Center for Physiology and Pathophysiology, Georg August University of Gottingen, Gottingen, Germany
J Neurophysiol 99:112-21. 2008..data indicate that in the MeCP2 -/y mice specific synaptic molecules and signaling pathways are impaired in the brain stem during early postnatal development...
- Long-term meditation is associated with increased gray matter density in the brain stemPeter Vestergaard-Poulsen
Center for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Neuroreport 20:170-4. 2009..Using magnetic resonance imaging, we observed higher gray matter density in lower brain stem regions of experienced meditators compared with age-matched nonmeditators...
- Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal sizeJames E Blevins
VA Puget Sound Health Care System, Research Service 151 1660 S Columbian Wy, Seattle, WA 98108, USA
Am J Physiol Regul Integr Comp Physiol 287:R87-96. 2004....
- Musical experience shapes human brainstem encoding of linguistic pitch patternsPatrick C M Wong
The Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, Illinois 60208 3540, USA
Nat Neurosci 10:420-2. 2007....
- Descending control of nociception: Specificity, recruitment and plasticityM M Heinricher
Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA
Brain Res Rev 60:214-25. 2009....
- Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellumVincent Y Wang
Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Neuron 48:31-43. 2005....
- Persistent inflammation alters the function of the endogenous brain stem cell compartmentStefano Pluchino
Neuroimmunology Unit, DIBIT, San Raffaele Scientific Institute, Milano, Italy
Brain 131:2564-78. 2008..g. ischaemic stroke), the plasticity of the endogenous brain stem cell compartment in chronic CNS inflammatory disorders remains poorly characterized...
- Brain stem is a direct target for leptin's action in the central nervous systemToru Hosoi
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
Endocrinology 143:3498-504. 2002..that peripherally applied leptin increased STAT3 phosphorylation not only in the hypothalamus but also in the brain stem as assessed by Western blotting...
- Cytokine immunopathogenesis of enterovirus 71 brain stem encephalitisShih Min Wang
Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan
Clin Dev Immunol 2012:876241. 2012..It can also cause severe complications of the central nervous system (CNS). Brain stem encephalitis with pulmonary edema is the severe complication that can lead to death...
- Brain stem mechanisms underlying acupuncture modality-related modulation of cardiovascular responses in ratsWei Yi Syuu Zhou
Department of Medicine, College of Medicine, Univ of California, Irvine, CA 92697 4075, USA
J Appl Physiol (1985) 99:851-60. 2005The present study was designed to investigate brain stem responses to manual acupuncture (MA) and electroacupuncture (EA) at different frequencies at pericardial P (5-6) acupoints located over the median nerve...
- Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neuronsPing Song
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nat Neurosci 8:1335-42. 2005..1 current, facilitating high-frequency spiking. Our results indicate that the intrinsic electrical properties of auditory neurons are rapidly modified to adjust to the ambient acoustic environment...
- Plasticity in the adult human auditory brainstem following short-term linguistic trainingJudy H Song
Northwestern University, Evanston, IL, USA
J Cogn Neurosci 20:1892-902. 2008....
- Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severityS M Wang
Department of Emergency Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan
Clin Microbiol Infect 13:677-82. 2007..quantitative relationship between specific cytokines in the cerebrospinal fluid (CSF) and the severity of EV71 brain stem encephalitis (BE), and investigated whether the CSF cytokine response differed from that to uncomplicated ..
- Effect of the long-term feeding of dietary lipids on the learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in adult mice: a comparison of sardine oil diet with palm oil dietH Suzuki
National Food Research Institute, Tsukuba, Ibaraki, Japan
Mech Ageing Dev 101:119-28. 1998..of 12 month feeding of 5% palm oil or sardine oil diet on the maze-learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in mice was studied...
- Enzymatic degradation of prion protein in brain stem from infected cattle and sheepJan P M Langeveld
Division of Infectious Diseases and Food Chain Quality, Institute for Animal Science and Health, Lelystad, The Netherlands
J Infect Dis 188:1782-9. 2003..This enzymatic process could lead to the development of a method for the decontamination of medical and laboratory equipment. The ultimate effectiveness of this method of prion inactivation has to be tested in mouse bioassays...
- Stimulation of the parapyramidal region of the neonatal rat brain stem produces locomotor-like activity involving spinal 5-HT7 and 5-HT2A receptorsJun Liu
Department of Physiology, Spinal Cord Research Centre, University of Manitoba Winnipeg, Winnipeg, Canada
J Neurophysiol 94:1392-404. 2005..Here we show for the first time that activation of a discrete population of 5-HT neurons in the rodent brain stem produces locomotion and that the evoked locomotion requires 5-HT7 and 5-HT2A receptors...
- The thalamus and brainstem act as key hubs in alterations of human brain network connectivity induced by mild propofol sedationTommaso Gili
Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, CF10 3AT, United Kingdom
J Neurosci 33:4024-31. 2013....
- MRI of Wolfram syndrome (DIDMOAD)P Galluzzi
Department of Neuroradiology, Policlinico Le Scotte, Azienda Ospedaliera Senese, Viale M Bracci, 1, 53100 Siena, Italy
Neuroradiology 41:729-31. 1999..lobe of the pituitary, shrinkage of optic nerves, chiasm and tracts, atrophy of the hypothalamic region, brain stem, cerebellum, and cerebral cortex...
- Selective attention affects human brain stem frequency-following responseGary C Galbraith
Department of Psychiatry and Biobehavioral Sciences, Mental Retardation Research Center, University of California at Los Angeles, Research Group at Lanterman Developmental Center, P O Box 100 R, Pomona, CA 91769, USA
Neuroreport 14:735-8. 2003..However, there is controversy concerning the effects of selective attention on short-latency brain stem evoked potentials...
- A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imagingPaul Dunckley
Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
J Neurosci 25:7333-41. 2005..05, Pearson's r, two-tailed) but not somatic stimulation. We propose that the differences in NCF and right PAG activation observed may represent a greater nocifensive response and greater emotive salience of visceral over somatic pain...
- Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neuronsAngel Nunez
Departamento de Morfologia, Facultad de Medicina, Universidad, Autonoma de Madrid, 28029, Spain
J Neurophysiol 89:3008-17. 2003..factor I (IGF-I) elicits a prolonged increase in the excitability of dorsal column nuclei (DCN) cells in the brain stem as well as other target neurons within the brain...
- Spinal and supraspinal postural networksT G Deliagina
Department of Neuroscience, Karolinska Institute, SE 17177, Stockholm, Sweden
Brain Res Rev 57:212-21. 2008..The postural capacity of spinal networks was evaluated in animals with lesions to the spinal cord. Relative contribution of spinal and supraspinal mechanisms to the stabilization of trunk orientation is discussed...
- Brain stem and cortical mechanisms underlying the binaural masking level difference in humans: an auditory steady-state response studyWinnie Y S Wong
School of Audiology and Speech Sciences, University of British Columbia, Vancouver, B C, Canada
Ear Hear 25:57-67. 2004The behavioral binaural masking level difference (BMLD) is believed to reflect brain stem processing...
- From brainstem to cortex: computational models of saccade generation circuitryB Girard
Laboratoire de Physiologie de la Perception et de l Action, UMR 7152, CNRS College de France, Paris, France
Prog Neurobiol 77:215-51. 2005..Moreover, beyond the multiple research topics remaining to be solved locally, questions regarding the operation of the whole structure can now be addressed by building on the existing models...
- Quantitative analysis of calcium-dependent vesicle recruitment and its functional role at the calyx of Held synapseNobutake Hosoi
Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
J Neurosci 27:14286-98. 2007..We could also demonstrate an approximate sixfold increase in release probability (facilitation) during the initial 5-15 AP-like stimuli of such trains in our experimental condition, regardless of EPSC depression...
- A low-affinity antagonist reveals saturation and desensitization in mature synapses in the auditory brain stemSoham Chanda
Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
J Neurophysiol 103:1915-26. 2010..Dynamic-clamp experiments indicated that desensitization can reduce BC spike probability and increase latency and jitter. Thus desensitization may affect sound processing in the mature auditory system...
- Transsynaptic EphB/Ephrin-B signaling regulates growth of presynaptic boutons required for classical conditioningWei Li
Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion, South Dakota 57069, USA
J Neurosci 31:8441-9. 2011..They also reveal a functional interaction between BDNF/TrkB and the Eph/ephrin signaling systems in the coordination of presynaptic and postsynaptic modifications during conditioning...
- Engrailed genes control developmental fate of serotonergic and noradrenergic neurons in mid- and hindbrain in a gene dose-dependent mannerHorst H Simon
Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, 69120 Heidelberg, Germany
Mol Cell Neurosci 28:96-105. 2005..An almost identical phenotype is found in mutant mice null for Wnt1, indicating that the engrailed genes provide essential positional information for the development of the two nuclei during early embryogenesis...
- Sumoylation of hypoxia-inducible factor-1α ameliorates failure of brain stem cardiovascular regulation in experimental brain deathJulie Y H Chan
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
PLoS ONE 6:e17375. 2011..It follows that sumoylation of HIF-1α in RVLM in response to hypoxia may play a modulatory role on brain stem cardiovascular regulation during experimental brain death.
- Fatal breathing dysfunction in a mouse model of Leigh syndromeAlbert Quintana
Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA, USA
J Clin Invest 122:2359-68. 2012..Magnetic resonance imaging revealed hyperintense bilateral lesions in the dorsal brain stem vestibular nucleus (VN) and cerebellum of severely affected mice...
- Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: a role for superoxide and nitric oxideAnuradha Guggilam
Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, 1909 Skip Bertman Drive, Baton Rouge, LA 70803, USA
Basic Res Cardiol 106:273-86. 2011..These results indicate that elevated TNF in these autonomic regulatory regions of the brain alter the production of superoxide and nitric oxide, contributing to fluid imbalance and sympathoexcitation in CHF...
- Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neuronsCarolyn M Macica
Department of Pharmacology, Yale University, New Haven, Connecticut 06520, USA
J Neurosci 23:1133-41. 2003..Our results suggest that modulation of Kv3.1 by phosphorylation allows auditory neurons to tune their responses to different patterns of sensory stimulation...
- Mapping the face in the somatosensory brainstemReha S Erzurumlu
Department of Anatomy and Neurobiology, University of Maryland, School of Medicine, Baltimore, 21201 Maryland, USA
Nat Rev Neurosci 11:252-63. 2010..Such position-dependent information is fundamental in transforming the early spatial layout of sensory receptors into a topographic connectivity map that is conferred to higher brain levels...
- Effects of CXCR3 signaling on development of fatal encephalitis and corneal and periocular skin disease in HSV-infected mice are mouse-strain dependentPatric Lundberg
Division of Virology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
Invest Ophthalmol Vis Sci 48:4162-70. 2007..The role of CXCR3 chemokine signaling in HSV-induced central nervous system (CNS) inflammation and corneal disease was evaluated, and responses in genetically susceptible and resistant strains of mice were contrasted...
- The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitisPatric Lundberg
Division of Virology, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
J Virol 82:7078-88. 2008..Susceptible 129S6 (129) but not resistant C57BL/6 (B6) mice developed intense focal inflammatory brain stem lesions of primarily F4/80(+) macrophages and Gr-1(+) neutrophils detectable by magnetic resonance imaging as ..
- Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanismsJ C Smith
Cellular and Systems Neurobiology Section, Porter Neuroscience Research Center, NINDS, NIH, Bethesda, MD 20892, USA
J Neurophysiol 98:3370-87. 2007..Network architectures that enable these features are not well understood. Here we studied organization of the brain stem respiratory CPG...
- Task2 potassium channels set central respiratory CO2 and O2 sensitivityChristian Gestreau
Department of Neurovegetative Physiology, Centre National de la Recherche Scientifique, Universite Paul Cezanne, 13397 Marseille, France
Proc Natl Acad Sci U S A 107:2325-30. 2010..These data identify Task2 as a determinant of central O(2) chemoreception and demonstrate that this phenomenon is due to the activity of a small number of neurons located at the ventral medullary surface...
- Neural pathways underlying vocal controlUwe Jürgens
German Primate Centre, Kellnerweg 4, 37077 Gottingen, Germany
Neurosci Biobehav Rev 26:235-58. 2002..And it needs an input from the supplementary and pre-supplementary motor area which give rise to the motor commands executed by the motor cortex...
- Short-term plasticity at the calyx of HeldHenrique von Gersdorff
The Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
Nat Rev Neurosci 3:53-64. 2002..The calyx of Held has also provided fresh insights into the strategies used by synapses to extend their dynamic range of operation and preserve the timing of sensory stimuli...
- Regional brain stem atrophy in idiopathic Parkinson's disease detected by anatomical MRIThomas Jubault
Unité de Neuroimagerie Fonctionelle, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
PLoS ONE 4:e8247. 2009..However, if such a regular neurodegenerative pattern were to exist, consistent damages would be found in the brain stem, even at early stages of the disease...
- The changing balance of brainstem-spinal cord modulation of pain processing over the first weeks of rat postnatal lifeG J Hathway
Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
J Physiol 587:2927-35. 2009..These data demonstrate, for the first time, the changing postnatal influence of the RVM in spinal nociception and highlight the central role of descending brainstem control in the maturation of pain processing...
- Identifying brain activity specifically related to the maintenance and perceptual consequence of central sensitization in humansMichael C Lee
Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, United Kingdom
J Neurosci 28:11642-9. 2008....
- Projections of the paratrigeminal nucleus to the ambiguus, rostroventrolateral and lateral reticular nuclei, and the solitary tractH de Sousa Buck
Department of Biophysics, Escola Paulista de Medicina, , Brazil
Auton Neurosci 87:187-200. 2001....
- Modules in the brain stem and spinal cord underlying motor behaviorsJinsook Roh
McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
J Neurophysiol 106:1363-78. 2011..We address whether the brain stem and spinal cord are involved in expressing muscle synergies used for executing a range of natural movements...
- Muscimol infusions in the brain stem reticular formation reversibly block ingestion in the awake ratZ Chen
College of Dentistry, Section of Oral Biology, Ohio State University, 305 W. at 12th Ave, Columbus, OH 43218, USA
Am J Physiol Regul Integr Comp Physiol 280:R1085-94. 2001..In contrast, midline infusions of muscimol did not affect licking or rejection responses. We postulate that the lateral medullary RF is an essential final common path for ingestive consummatory responses...
- Upper airway dysfunction of Tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nucleiMathias Dutschmann
Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
J Neurosci 30:1810-21. 2010..Because patients with tauopathy suffer from upper airway dysfunction, the Tau-P301L mice can serve as an experimental model to study disease-specific synaptic dysfunction in well defined functional neural circuits...
- Bickerstaff's brainstem encephalitis: clinical features of 62 cases and a subgroup associated with Guillain-Barré syndromeMasaaki Odaka
Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
Brain 126:2279-90. 2003..A considerable number of BBE patients have associated axonal Guillain-Barré syndrome, indicative that the two disorders are closely related and form a continuous spectrum...
- Encoding of pitch in the human brainstem is sensitive to language experienceAnanthanarayan Krishnan
Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN 47907 2038, USA
Brain Res Cogn Brain Res 25:161-8. 2005..Rather, these results support the possibility of neural plasticity at the brainstem level that is induced by language experience that may be enhancing or priming linguistically relevant features of the speech input...
- A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrateS K Afridi
Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Brain 128:932-9. 2005..Consistent with previous work, the activation persisted after pain was controlled by sumatriptan. These results suggest that lateralization of pain in migraine is due to lateralized brain dysfunction...
- Plasticity of the auditory brainstem: effects of cochlear ablation on GAP-43 immunoreactivity in the ratR B Illing
Department of Otorhinolaryngology, University of Freiburg, Germany
J Comp Neurol 382:116-38. 1997..Given the functional significance attributed to GAP-43, we conclude that the sudden loss of spiral ganglion cells leads to a reactive synaptogenesis in complex patterns across several auditory brainstem nuclei...
- Differential intrinsic response dynamics determine synaptic signal processing in frog vestibular neuronsMathieu Beraneck
Laboratoire de Neurobiologie des Reseaux Sensorimoteurs, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7060, Universite Paris Descartes, 75270 Paris Cedex 06, France
J Neurosci 27:4283-96. 2007....
- The role of timing in the brain stem auditory nuclei of vertebratesD Oertel
Department of Physiology, University of Wisconsin, Madison 53706, USA
Annu Rev Physiol 61:497-519. 1999..The monaural nuclei of the lateral lemniscus, whose roles are not understood (although they are ubiquitous in higher vertebrates), receive input from multiple pathways that encode timing with precision, some through calyceal endings...
- Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstemA J Todd
Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ UK
Eur J Neurosci 12:689-700. 2000..These results demonstrate that dorsal horn neurons which express the neurokinin 1 receptor contribute to several ascending pathways that are thought to be important in pain mechanisms...
- Optimizing synaptic architecture and efficiency for high-frequency transmissionHolger Taschenberger
The Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
Neuron 36:1127-43. 2002..A greater multiplicity of small AZs with few docked vesicles, a larger pool of releasable vesicles, and a higher efficiency of release thus promote prolonged high-frequency firing in mature synapses...
- Staggered development of GABAergic and glycinergic transmission in the MNTBGautam B Awatramani
Oregon Hearing Research Center Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
J Neurophysiol 93:819-28. 2005Maturation of some brain stem and spinal inhibitory systems is characterized by a shift from GABAergic to glycinergic transmission...
- Differential expression of apoptosis-related genes in the cochlea of noise-exposed ratsB H Hu
Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, NY 14214, USA
Neuroscience 161:915-25. 2009..These constitutively expressed genes, together with the inducible genes, may participate in the induction of cochlear apoptotic activity...
- Development of spontaneous mouth/tongue movement and related neural activity, and their repression in fetal mice lacking glutamate decarboxylase 67Naoko Tsunekawa
Obata Research Unit, RIKEN Brain Science Institute, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
Eur J Neurosci 21:173-8. 2005....
- Context-dependent encoding in the human auditory brainstem relates to hearing speech in noise: implications for developmental dyslexiaBharath Chandrasekaran
Roxelyn and Richard Pepper Department of Communication Sciences, Northwestern University, Evanston, IL 60208, USA
Neuron 64:311-9. 2009..The disruption of this mechanism contributes to a critical deficit in noise-exclusion, a hallmark symptom in developmental dyslexia...
- Neural bases of goal-directed locomotion in vertebrates--an overviewSten Grillner
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
Brain Res Rev 57:2-12. 2008....
- Brain stem circuits mediating prepulse inhibition of the startle reflexM Fendt
Tierphysiologie, Universitat Tubingen, Germany
Psychopharmacology (Berl) 156:216-24. 2001..Prepulse inhibition (PPI) of the startle reflex occurs when brief, non-startling tactile, acoustic or visual stimuli are presented 20-500 ms before the startling stimulus...
- Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophyK Wakabayashi
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
Neurosci Lett 249:180-2. 1998..These findings indicate that alpha-synuclein is also a major component of GCIs and NCIs in MSA and strongly suggest that alpha-synuclein aggregation is a common process in certain neurodegenerative diseases, including PD and MSA...
- Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channelsWeiqi Zhang
Center for Physiology and Pathophysiology, Georg August University, D 37073 Gottingen, Germany
J Neurosci 25:4330-42. 2005....
- A working heart-brainstem preparation of the mouseJ F Paton
Department of Physiology, School of Medical Sciences, University of Bristol, UK
J Neurosci Methods 65:63-8. 1996..The WH-BP may provide an advantaged environment for analysis of both synaptic and cellular mechanisms within the medulla that regulate cardio-respiratory activity...
- The calyx of HeldRalf Schneggenburger
Laboratory of Synaptic Mechanisms, Ecole Polytechnique Federale de Lausanne EPFL, Brain Mind Institute, Bâtiment AAB, Station 15, CH 1015 Lausanne, Switzerland
Cell Tissue Res 326:311-37. 2006..Together, these studies convey the panopoly of presynaptic regulatory processes underlying the regulation of transmitter release, its modulatory control and short-term plasticity within one identified synaptic terminal...
- Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptorsWenjun Zhang
Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA
Brain 132:778-87. 2009..These data support our hypothesis and identify CCK2-MOR co-expressing neurons in the RVM as potential therapeutic targets for neuropathic pain...
- Magnetic resonance imaging reveals neuronal degeneration in the brainstem of the superoxide dismutase 1 transgenic mouse model of amyotrophic lateral sclerosisDa Wei Zang
Howard Florey Institute, The University of Melbourne, Parkville, Victoria 3010, Australia
Eur J Neurosci 20:1745-51. 2004..This atrophy was confirmed by fresh brain weight data. The extensive global degeneration involving multiple structures suggests a multisystem disease that is similar to human ALS...
- Fenestration of the calyx of Held occurs sequentially along the tonotopic axis, is influenced by afferent activity, and facilitates glutamate clearanceMarc C Ford
Division of Neurobiology, Ludwig Maximilians University Munich, Martinsried, Germany
J Comp Neurol 514:92-106. 2009....
- Auditory efferent feedback system deficits precede age-related hearing loss: contralateral suppression of otoacoustic emissions in miceXiaoxia Zhu
Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 8629, USA
J Comp Neurol 503:593-604. 2007..In conclusion, the C57 mouse has MOC function at 6 weeks, but it declines quickly, preceding the progression of peripheral age-related sensitivity deficits and hearing loss in this mouse strain...
- Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogenH Braak
Institute for Clinical Neuroanatomy, University of Frankfurt, Frankfurt Main, Germany
J Neural Transm 110:517-36. 2003..In the lower brain stem, the process begins in the dorsal motor nucleus of the vagus nerve and advances from there essentially upwards ..
- Differences in transductional tropism of adenoviral and lentiviral vectors in the rat brainstemHanad Duale
Department of Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Exp Physiol 90:71-8. 2005..Thus, the present study provides compelling evidence that VSVG-coated LVVs significantly shift transgene expression towards neurones while transduction with AVVs favours glia...
- Comparison of c-fos-like immunoreactivity in the brainstem following intraoral and intragastric infusions of chemical solutions in ratsT Yamamoto
Department of Behavioral Physiology, Faculty of Human Sciences, Osaka University, 1 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
Brain Res 866:144-51. 2000..These results indicate that c-fos induction in brainstem neurons during ingestion reflects gustatory inputs and postingestional factors depending on the kind of food ingested...
- Neural correlates of consonance, dissonance, and the hierarchy of musical pitch in the human brainstemGavin M Bidelman
Department of Speech Language, Hearing Sciences, Purdue University, West Lafayette, Indiana 47907 2038, USA
J Neurosci 29:13165-71. 2009....
- Mapping of neural activity produced by thermal pain in the healthy human spinal cord and brain stem: a functional magnetic resonance imaging studyCatherine M Cahill
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada K7L 3N6
Magn Reson Imaging 29:342-52. 2011..Activity was greater in the spinal cord and brain stem in earlier experiments, compared with repeated experiments after the more noxious (46 °C) stimulus had been ..
- Brain stem and cerebellar findings in Joubert syndromeIbrahim A Alorainy
Department of Radiology and Medical Imaging, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
J Comput Assist Tomogr 30:116-21. 2006..The purpose of this paper is to illustrate the brain stem and cerebellar imaging findings in Joubert syndrome...
- Far field potentials from brain stem after transcutaneous vagus nerve stimulation: optimization of stimulation and recording parametersThomas Polak
Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University, 97080 Wurzburg, Germany
J Neural Transm (Vienna) 116:1237-42. 2009The method of vagus somatosensory evoked potentials (VSEP) was introduced to easily measure the activity of vagus brain stem nuclei...
- Transcription factors and the genetic organization of brain stem respiratory neuronsPaul A Gray
Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110 1093, USA
J Appl Physiol (1985) 104:1513-21. 2008Breathing is a genetically determined behavior generated by neurons in the brain stem. Transcription factors, in part, determine the basic developmental identity of neurons, but the relationships between these genes and the neural ..
- Motor cortex electrical stimulation promotes axon outgrowth to brain stem and spinal targets that control the forelimb impaired by unilateral corticospinal injuryJason B Carmel
Departments of Neurology and Neuroscience and Pediatrics, Weill Cornell Medical College, New York, NY 10021, USA
Eur J Neurosci 37:1090-102. 2013..Here, we tested: (i) if M1 stimulation only increases spinal axon length or if it also promotes connections to brain stem forelimb control centers, especially magnocellular red nucleus; and (ii) if stimulation-induced increase in axon ..
- Anatomy and regulation of the central melanocortin systemRoger D Cone
Vollum Institute and the Center for the Study of Weight Regulation, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
Nat Neurosci 8:571-8. 2005....
- Evidence for increased nitric oxide production in the auditory brain stem of the aged dwarf hamster (Phodopus sungorus): an NADPH-diaphorase histochemical studyS Reuss
Department of Anatomy, School of Medicine, Johannes Gutenberg University, Mainz, Germany
Mech Ageing Dev 112:125-34. 2000..The superior olivary complex (SOC), a group of interrelated brain stem nuclei, projects to a variety of neuronal structures including the cochlea and the inferior colliculus (IC)...
- Post-tetanic potentiation in the rat calyx of Held synapseRon L P Habets
Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
J Physiol 564:173-87. 2005..Although part of the PTP can be explained by a direct activation of the calcium sensor for phasic release, other mechanisms are likely to contribute as well...
- Anticipatory brainstem activity predicts neural processing of pain in humansMerle Fairhurst
Department of Physiology, Anatomy and Genetics, Department of Clinical Neurology, University of Oxford, Oxford OX1 3QX, United Kingdom
Pain 128:101-10. 2007..Together, the results suggest a possible role of brainstem areas in anticipatory mechanisms involved in the maintenance of chronic pain...
- Implanted embryonic sensory neurons project axons toward adult auditory brainstem neurons in roller drum and Stoppini co-culturesCharoensri Thonabulsombat
Department of Anatomy, Faculty of Science, Bangkok 10400 and Institute of Science and Technology for Research and Development, Mahidol University, Salaya, Phutthamonthon, Nakorn Pathom 73170, Thailand
Brain Res 1170:48-58. 2007....
- Altered glycinergic synaptic activities in guinea pig brain stem auditory nuclei after unilateral cochlear ablationS J Potashner
Department of Anatomy, University of Connecticut Health Center, Farmington, CT 06030, USA
Hear Res 147:125-36. 2000..Third, several tissues exhibited various transient changes in activity. These types of post-lesion change might contribute to altered auditory functions, which often accompany hearing loss...
- Relative maturation of peripheral and central regions of the human brainstem from preterm to term and the influence of preterm birthZe D Jiang
Children s Hospital, Fudan University, Shanghai, China
Pediatr Res 65:657-62. 2009..Preterm birth slightly delays early maturation of central brainstem regions...
- Assessment of MRI abnormalities of the brainstem from patients with migraine and multiple sclerosisPaola Tortorella
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
J Neurol Sci 244:137-41. 2006..In patients with migraine, functional changes have been described in the red nucleus (RN), substantia nigra (SN) and periaqueductal gray matter (PAG)...
- Timing of impulses from the central amygdala and bed nucleus of the stria terminalis to the brain stemFrank Z Nagy
Center for Molecular and Behavioral Neuroscience, The State University of New Jersey, Newark, NJ 07102, USA
J Neurophysiol 100:3429-36. 2008..connections, we compared the antidromic response latencies of BNST and central amygdala (CE) neurons to brain stem stimulation...
- Vacuolization correlates with spin-spin relaxation time in motor brainstem nuclei and behavioural tests in the transgenic G93A-SOD1 mouse model of ALSSelina Bucher
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
Eur J Neurosci 26:1895-901. 2007..Finally, our data suggest that MRI does not only resemble the findings of behavioural tests, but is potentially superior to behavioural studies...
- Comparison of 3D FLAIR, 2D FLAIR, and 2D T2-weighted MR imaging of brain stem anatomyM Kitajima
Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan 860 8556
AJNR Am J Neuroradiol 33:922-7. 2012Although 3D FLAIR imaging visualizes detailed structures of the brain stem, it has not been used to evaluate its normal anatomy...
- Evidence for a widespread brain stem escape network in larval zebrafishEthan Gahtan
Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA
J Neurophysiol 87:608-14. 2002..We therefore recorded the activity of other descending neurons in the brain stem using confocal imaging of cells retrogradely labeled with fluorescent calcium indicators...
- Learning to encode timing: mechanisms of plasticity in the auditory brainstemThanos Tzounopoulos
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuron 62:463-9. 2009..However, recent groundbreaking results from animal models and human studies have revealed remarkable evidence for cellular and behavioral mechanisms for learning and memory in the auditory brainstem...
- IL-6 deficiency leads to reduced metallothionein-I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatmentM Penkowa
Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
Exp Neurol 163:72-84. 2000..of a niacin antagonist, 6-aminonicotinamide (6-AN), which causes both astroglial degeneration/cell death in brain stem gray matter areas and BM toxicity...
- The role of arousal related brainstem reflexes in causing recovery from upper airway occlusion in infantsHenning Wulbrand
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
Sleep 31:833-40. 2008..Lung inflation is not a prerequisite for the reflex to occur...
- Failed heart rate recovery at a critical age in 5-HT-deficient mice exposed to episodic anoxia: implications for SIDSKevin J Cummings
Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
J Appl Physiol (1985) 111:825-33. 2011..They may apply to the sudden infant death syndrome, which occurs at a critical age and is associated with 5-HT deficiency...
- EphB signaling regulates target innervation in the developing and deafferented auditory brainstemPaul A Nakamura
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
Dev Neurobiol 72:1243-55. 2012..We have also found that ephrin-B reverse signaling repels induced projections to the ipsilateral MNTB after unilateral deafferentation, suggesting that similar mechanisms regulate these two processes...
- MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholicsRosemarie Kryger
Department of Biochemistry, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia
Alcohol 46:629-34. 2012..transcripts was detected in cerebellum of human alcoholics and increases were also noted in hippocampus and brain stem, while no significant increase of MALAT-1 expression was noted in frontal or motor cortices...
- Xenografted fetal dorsal root ganglion, embryonic stem cell and adult neural stem cell survival following implantation into the adult vestibulocochlear nerveC Regala
Department of Clinical Neuroscience, Section of Otorhinolaryngology, Karolinska Institutet, Karolinska Hospital, PO Box SE 171 76 Stockholm, Sweden
Exp Neurol 193:326-33. 2005..at the site of injection in the vestibulocochlear nerve of the host rats and guinea pigs but also within the brain stem. Thy 1.2 profiles were seen among the EGFP ES cells within the 8th cranial nerve...
- Pathology of post traumatic brainstem and hypothalamic injuriesD Shukla
Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India
Clin Neuropathol 26:197-209. 2007..We studied brains of 47 patients who succumbed to head injury, with special attention to topographical distribution of brainstem and hypothalamic injuries...
- The conformation of the brain plays an important role in the distribution of diffuse axonal injury in fatal road traffic accidentJosé Eymard Homem Pittella
Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Arq Neuropsiquiatr 62:406-12. 2004..A study was made of the brain lesions in 120 random victims of fatal road traffic accidents to determine the frequency and topographic distribution of diffuse axonal damage (DAI) in relation to the midline brain structures...
- Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical IllnessEva Szigethy; Fiscal Year: 2009..abstract_text> ..
- NIH Director's Pioneer AwardERICH JARVIS; Fiscal Year: 2009..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
- Exercise training and blood pressure in hypertension: integrated mechanismsNoreen F Rossi; Fiscal Year: 2012....
- ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYSPatrice G Guyenet; Fiscal Year: 2013..This research focuses on specific neuronal networks located in the lower part of the brain called the medulla oblongata and its ultimate goal is to uncover novel treatments for OSA and other sleep-related respiratory disorders. ..
- Chronic nicotine and synaptic transmission in brainstem respiratory neuronsRALPH FRANK FREGOSI; Fiscal Year: 2013..It is therefore crucial to begin establishing the mechanisms that lead to abnormal development of the brainstem neurons that regulate these critical homeostatic functions. ..
- Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 ReceptorsMark W Chapleau; Fiscal Year: 2013..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
- Steroid Responsive Mechanisms in the EarDENNIS ROYAL TRUNE; Fiscal Year: 2012..Of particular interest are immune suppression of inflammatory cytokines and related transcription factors compared to the regulation of ion transport pathways that control fluid homeostasis. ..
- The Neuroimmunology of Viral InfectionDANIEL J CARR; Fiscal Year: 2013..Preliminary, unpublished data suggest the resident cells residing in the brain stem with an intact type I IFN system are critical to control viral infection whereas in the peripheral nervous ..
- Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growthMarlan R Hansen; Fiscal Year: 2013..The results of these studies will provide insights into the fundamental mechanisms contributing to VS cell growth and radiosensitivity and will likely contribute to the development of novel therapies for VSs. ..
- GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic MouseRobert L Nussbaum; Fiscal Year: 2012..enteric nervous system (ENS), while PD pathology in the CNS appeared at older ages, affecting predominantly the brain stem, as well as in the ENS...
- Amelioration of cisplatin ototoxicity by transplatinDebashree Mukherjea; Fiscal Year: 2010..Otoprotection will be assessed by auditory brain stem responses (ABRs) and by assessing the morphology of cochlear inner and outer hair cells, using scanning electron ..
- Persisting Grand Mal and Myoclonic Seizures in JME including VeteransAntonio V Delgado-Escueta; Fiscal Year: 2013..Understanding JME disease mechanisms brings an era of targeted and designer medicine, and positively impacts the mission of the VA healthcare system and the health of Veterans. ..
- Role of Dendritic Ca2+ Transients in Respiratory Rhythm GenerationJack L Feldman; Fiscal Year: 2010..The proposed studies will significantly advance our understanding of the neural mechanisms generating respiratory rhythm and shed light on human disorders of breathing. ..
- Mechanisms of Cochlear Oxidative Stress Injury and Strategies to Protect HearingMichael J Brenner; Fiscal Year: 2013..The long-term goal of this research is to develop safe and effective strategies to prevent hearing loss related to aminoglycoside antibiotic therapy. ..
- The Role of the Terminal Complement Pathway in ALSScott R Barnum; Fiscal Year: 2013..These studies will provide new information regarding the role of complement in ALS and potentially new therapeutic directions. ..
- Hiv-1 Infection: Central Serotonergic Activity and its Health ImplicationsAdarsh M Kumar; Fiscal Year: 2010..We will determine the levels of 5-HT and its metabolite, 5-HIAA in the brain stem raphe nuclei, where the cell bodies of serotonergic neurons are located and 5-HT is synthesized, as well as in ..
- BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROMEHANNAH CHASE KINNEY; Fiscal Year: 2013..Our goal is to determine the fundamental basis of this deficiency by state-of-the-art techniques in human brainstem analysis. Such knowledge is essential to the future development of a means to identify and treat living infants at risk. ..
- HYPOXIA AND CONTROL OF FETAL BREATHING MOVEMENTSBrian J Koos; Fiscal Year: 2010..Thus, the proposed studies are directly applicable to the morbidity and mortality of heart and breathing disorders in infants, children, and adults, including prolonged sleep apnea, brain injury, and sudden death. ..
- Effects of nerve demyelination on auditory synaptic functionsJun Hee Kim; Fiscal Year: 2012....
- TRANSCRIPTION FACTORS IN CONTROL OF BRAIN DEVELOPMENTEric E Turner; Fiscal Year: 2010....
- BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROMEHannah C Kinney; Fiscal Year: 2010..abstract_text> ..
- Plasticity of nTS output neurons in acute and chronic hypoxiaDAVID DOUGLAS KLINE; Fiscal Year: 2013..This will be done in a model of OSA with the expectation of understanding potential therapeutic interventions. ..
- Brain Nicotine Receptor Density &Response to Nicotine PatchArthur Brody; Fiscal Year: 2013..Additionally, we will explore whether the combination of information from the PET images and rating scales can be used to identify even more robustly who will quit smoking with nicotine patch treatment. ..
- CONTROL OF GONADOTROPIN SECRETION DURING LACTATIONKevin L Grove; Fiscal Year: 2013..These studies will identify new pathways that regulate kisspeptin neurons that in turn control GnRH neurons and could lead to new treatments for restoring fertility or for new contraceptive agents that inhibit fertility. ..
- Neurochemistry/physiology of proopiomelanocortin neuronsMALCOLM JAMES LOW; Fiscal Year: 2013....
- Modulation of subcortical visual information processingCHARLES LEROY COX; Fiscal Year: 2012....
- Role of Oleylethanolamine in the Regulation of the HPT AxisCsaba Fekete; Fiscal Year: 2010....
- Basal Forebrain Cellular Mechanisms of Cortical ActivationRobert W McCarley; Fiscal Year: 2013..We thereby lay the groundwork for targeted therapies to improve alertness, attention, and executive function in conditions that affect the Veteran population such as schizophrenia, Alzheimer's disease and sleep disorders. ..
- Integration of sleep/wake network models across multiple temporal and spatial scaANDREW JOHN PHILLIPS; Fiscal Year: 2013..The proposed project will grant Dr. Phillips the necessary protected time to conduct research, achieve the necessary experience, and learn the requisite skills to achieve these long-term goals. ..
- How do Amine Neurons Work?Edward A Kravitz; Fiscal Year: 2013..Studies at these levels of detail are not possible in other species at the present time. ..
- NEUROPHYSIOLOGY OF PARASYMPATHETIC CARDIAC NEURONSDavid Mendelowitz; Fiscal Year: 2013....
- Presynaptic NMDAR Regulation of Substance P Release in the RVM After InjuryUCHECHUKWU PATRICK MADUKA; Fiscal Year: 2013....
- Sepsis Outcomes and Aging: Role of Sleep Disruption and the Blood Brain BarrierMark R Opp; Fiscal Year: 2013..use this approach to quantify cytokine profiles in plasma and discrete brain regions (hypothalamus, hippocampus, brain stem) from the same animal...
- Determinants of developing efferent synapses in the mammalian cochleaISABELLE CATHERINA ROUX; Fiscal Year: 2013..transiently and the outer hair cells (OHCs) permanently receive efferent innervation originating in the auditory brain stem. This cholinergic input is mediated by a9/a10nicotinic acetylcholine receptors (nAChRs) and is inhibitory due to ..
- Mechanism and functional role of AKAP79/150 in M current controlMark S Shapiro; Fiscal Year: 2012....
- Neural basis of learned food aversion and nauseaCHARLES HORN; Fiscal Year: 2009..Effective treatment of nausea may substantially improve the quality of life for patients with chronic disease. ..
- Nicotine Modulation of Parasympathetic Cardiac NeuronsDavid Mendelowitz; Fiscal Year: 2013....
- Control of Breathing and Pompe DiseaseDavid D Fuller; Fiscal Year: 2013..This renewal application targets optimization of adeno-associated virus (AAV) based therapies to treat respiratory neurons in Pompe disease. ..
- Hypocretin and Locus Ceruleus Interactions in Zebrafish Development and BehaviorGrigorios Oikonomou; Fiscal Year: 2012..This proposal aims to investigate the physical connections between these two centers, how these connections are formed during development and how these systems interact with each other to regulate sleep/wake behaviors. ! ..
- Translational refinement of adaptive communication system for locked-in patientsMelanie Fried-Oken; Fiscal Year: 2013..The proposed project stresses the translation of basic computer science into clinical care, supporting the proposed NIH Roadmap and public health initiatives. ..
- INTERACTIONS OF LEPTIN AND CENTRAL SEROTONIN SYSTEMSJoel K Elmquist; Fiscal Year: 2013..Results from these studies will advance our understanding of the serotoninergic circuits necessary to permit the design of effective treatment strategies for obesity and diabetes. ..
- Novel Approaches for Prevention and Treatment of Noise Induced Hearing lossDebashree Mukherjea; Fiscal Year: 2013..A successful outcome of this approach in the animal studies is expected to have direct translational application for the treatment of NIHL in human. ..
- CNS Mechanisms of Acute Hypoglycemia-Associate Autonomic FailureDIANNE FIGLEWICZ LATTEMANN; Fiscal Year: 2012....
- GENETIC ORGANIZATION OF RESPIRATORY CIRCUITS IN MOUSE BRAINSTEMPaul Gray; Fiscal Year: 2013..Understanding the genetic organization of the brainstem neurons that generate breathing is essential for the diagnosis and treatment of breathing disorders. ..
- The baroreflex in pregnancy: effects of adrenal and placental steroidsMaureen Keller-Wood; Fiscal Year: 2012....
- Transcutaneous vagus nerve stimulation in cerebral ischemiaIlknur Ay; Fiscal Year: 2013..If successful, the findings of these exploratory studies will be used in near future translational studies designed to optimize tVNS treatment for acute ischemic stroke in humans. ..
- Antisense oligonucleotides for the treatment of spinocerebellar ataxia type 2Daniel R Scoles; Fiscal Year: 2013..The proposed work will break new ground for treatment of neurodegenerative diseases by demonstrating feasibility of targeting dominant-acting mutated polyQ genes with antisense oligonucleotides. ..
- Bilateral cochlear implants: Physiology and psychophysicsBertrand Delgutte; Fiscal Year: 2012..These studies will likely lead to new electronic sound processors for bilateral implants that work better in noise and are better adapted to specific types of deafness histories. ..
- CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUSLarry W Swanson; Fiscal Year: 2012..The proposed research is designed to clarify very poorly understood neural circuits that mediate normal ingestive, defensive, reproductive, and sleep/wake behaviors;understanding their pathology will follow. ..
- Genetic and Functional Profiles of Serotonergic Neuron SubtypesRachael D Brust; Fiscal Year: 2013..g. channels, receptors) associated with CO2 chemosensitivity (Aim 3) that may potentially underlie this vital function. ..
- Functional Anatomy of REM Sleep: Brainstem-ControlGerald A Marks; Fiscal Year: 2013..This research proposal hopes to contribute to our knowledge on the role of REM sleep mechanisms in the etiology and reinforcement of these disorders. ..
- BMP7 and the regulation of central and peripheral energy balanceKristy Townsend; Fiscal Year: 2012..Therefore, the research outlined in this proposal could provide important new findings for the field of obesity research, and potentially lead to development of new obesity therapeutics. ..
- P450 Epoxygenase Mechanisms of Opioid AnalgesiaLINDSAY HOUGH; Fiscal Year: 2013..Despite substantial information on mu signaling, the mechanisms by which morphine activates brain stem analgesic circuits remain unknown...
- Hybrid atomic force-optical imaging system to investigate prenatal nicotineJeffrey Potts; Fiscal Year: 2009..It is also of clinical significance since nicotine replacement therapy for pregnant women is often regarded as a safe alternative in smoking cessation programs. ..
- Intestinal satiation in Roux-en-Y gastric bypass rats: brain mechanisms and sex dThomas Alexander Lutz; Fiscal Year: 2013....
- The effects of glucose on central vagal brainstem circuitsKIRSTEEN NAIRN BROWNING; Fiscal Year: 2013..abstract_text> ..
- Modulation of subcortical visual information processingCharles Cox; Fiscal Year: 2009..abstract_text> ..
- Coordination of orofacial and respiratory movementsDetlef H Heck; Fiscal Year: 2012..to the fastigial nucleus (FN) represent multiple orofacial movements and that FN neurons project to multiple brain stem pattern generators...
- Regulation of Brain Signaling After Bariatric SurgeryJonathan Q Purnell; Fiscal Year: 2010..food intake and energy expenditure through mechanisms that include direct binding to receptors in the brain stem and brain, and by altering afferent vagal signaling...
- CYTOLOGICAL STUDIES OF DEVELOPING AND MATURE NEURONSMary Bartlett Bunge; Fiscal Year: 2013..Discovery of translational methods to improve exiting of regenerated brainstem axons from the SC bridge into the cord will have an important impact on fostering spinal cord repair, particularly for the use of SCs to mend human SCIs. ..
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMICHAEL L CAMILLERI; Fiscal Year: 2010..Cannabinoid receptors (CBR) are on cholinergic neurons in the brain stem, stomach and colon...
- Risk factors for encephalopathy in newborns with severe hyperbilirubinemiaRICHARD PARTRIDGE WENNBERG; Fiscal Year: 2010....
- NEUROCHEMICALS IN HYPOTHALAMIC SIGNALING AFTER COITUSK Y Pau; Fiscal Year: 2000..Aim 3b will determine if electrical lesions of the nPGi and/or nPH prevent either the postcoital expression of LC cFos protein, TH/NET mRNAs or the LH surge. These studies may provide information on neurologically related infertility. ..
- TRIGEMINOHYPOTHALAMIC TRACTRami Burstein; Fiscal Year: 1999..One option to test such an hypothesis will be to lesion the pathway selectively and determine changes in the activity of the target neurons and/or in the behavior of the animal. ..
- RESPIRATORY SYSTEM INTEGRATION BY THE BRAINSTEMALBERT BERGER; Fiscal Year: 2002..We hypothesize that ethanol increases the affinity of glycine-Rs for glycine and thereby potentiates inhibitory synaptic events. This may be an important mechanism whereby alcohol consumption exacerbates obstructive sleep apnea. ..
- GENOTYPE AND PHENOTYPE OF BRAINSTEM INJURY IN AUTISMPatricia Rodier; Fiscal Year: 2007..studies, and studies of comorbid conditions suggest that one cause of autism is early maldevelopment of the brain stem. Evidence for several new candidate genes for ASD susceptibility has been published in the last year, and all ..
- Mu Opioid Receptor Regulation in Neonatal BrainstemGEORGE OLSEN; Fiscal Year: 2006..These studies will provide developmental information on guinea pig NTS MOR following chronic in utero opioid exposure. ..
- GENOTYPE AND PHENOTYPE OF BRAINSTEM INJURY IN AUTISMPatricia Rodier; Fiscal Year: 2002..when injury can cause autism has led to the insight that the disorder is initiated by changes in the developing brain stem. The shortening of the hindbrain and loss of cranial nerve neurons in an animal model of the insult and a human ..
- AUTOSOMAL DOMINANT ATAXIAChristopher Gomez; Fiscal Year: 2001..These studies will test the hypothesis that sensitive measures of eye movements and balance can be used to detect and quantify ataxia from its earliest stages. ..
- Trigeminal Autonomic InteractionsPaul McCulloch; Fiscal Year: 2002..Having a better understanding of brainstem cardiorespiratory integration might provide a neurological basis for the etiology of SIDS. ..