nervous system

Summary

Summary: The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)

Top Publications

  1. ncbi The basis of anisotropic water diffusion in the nervous system - a technical review
    Christian Beaulieu
    Department of Biomedical Engineering, Faculty of Medicine, University of Alberta, Edmonton, Canada
    NMR Biomed 15:435-55. 2002
  2. pmc Brain tumor microvesicles: insights into intercellular communication in the nervous system
    Kristan E van der Vos
    Department of Neurology, Boston, MA, USA
    Cell Mol Neurobiol 31:949-59. 2011
  3. ncbi Retinoic acid in the development, regeneration and maintenance of the nervous system
    Malcolm Maden
    MRC Centre for Developmental Neurobiology, fourth floor New Hunt s House, Guy s Campus, King s College London, London, SE1 1UL, UK
    Nat Rev Neurosci 8:755-65. 2007
  4. doi Purinergic signalling in the nervous system: an overview
    Maria P Abbracchio
    Department of Pharmacological Sciences, Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Via Balzaretti 9, University of Milan, 20133 Milan, Italy
    Trends Neurosci 32:19-29. 2009
  5. doi Histamine in the nervous system
    Helmut L Haas
    Institute of Neurophysiology, Heinrich Heine University, Duesseldorf, Germany
    Physiol Rev 88:1183-241. 2008
  6. doi Notch in the vertebrate nervous system: an old dog with new tricks
    Tarran Pierfelice
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 69:840-55. 2011
  7. doi Regulation of caspases in the nervous system implications for functions in health and disease
    Carol M Troy
    Department of Pathology and Cell Biology, Taub Center for the Study of Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, USA
    Prog Mol Biol Transl Sci 99:265-305. 2011
  8. pmc Neuropathic pain: a maladaptive response of the nervous system to damage
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Annu Rev Neurosci 32:1-32. 2009
  9. ncbi Ambra1 regulates autophagy and development of the nervous system
    Gian Maria Fimia
    National Institute for Infectious Diseases, IRCCS L Spallanzani, 00149 Rome, Italy
    Nature 447:1121-5. 2007
  10. doi Regulation of terminal differentiation programs in the nervous system
    Oliver Hobert
    Howard Hughes Medical Institute, New York, NY 10032, USA
    Annu Rev Cell Dev Biol 27:681-96. 2011

Detail Information

Publications382 found, 100 shown here

  1. ncbi The basis of anisotropic water diffusion in the nervous system - a technical review
    Christian Beaulieu
    Department of Biomedical Engineering, Faculty of Medicine, University of Alberta, Edmonton, Canada
    NMR Biomed 15:435-55. 2002
    ..Pertinent pathological models, developmental studies and theoretical analyses provide further insight into the basis of anisotropic diffusion and its potential utility in the nervous system.
  2. pmc Brain tumor microvesicles: insights into intercellular communication in the nervous system
    Kristan E van der Vos
    Department of Neurology, Boston, MA, USA
    Cell Mol Neurobiol 31:949-59. 2011
    ..This commentary explores the recent advances in this novel intercellular communication route and discusses the potential physiological role of microvesicles in brain tumorigenesis...
  3. ncbi Retinoic acid in the development, regeneration and maintenance of the nervous system
    Malcolm Maden
    MRC Centre for Developmental Neurobiology, fourth floor New Hunt s House, Guy s Campus, King s College London, London, SE1 1UL, UK
    Nat Rev Neurosci 8:755-65. 2007
    ..The data described here strongly suggest that RA could be used as a therapeutic molecule for the induction of axon regeneration and the treatment of neurodegeneration...
  4. doi Purinergic signalling in the nervous system: an overview
    Maria P Abbracchio
    Department of Pharmacological Sciences, Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Via Balzaretti 9, University of Milan, 20133 Milan, Italy
    Trends Neurosci 32:19-29. 2009
    ....
  5. doi Histamine in the nervous system
    Helmut L Haas
    Institute of Neurophysiology, Heinrich Heine University, Duesseldorf, Germany
    Physiol Rev 88:1183-241. 2008
    Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the skin, and the immune system...
  6. doi Notch in the vertebrate nervous system: an old dog with new tricks
    Tarran Pierfelice
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 69:840-55. 2011
    ..Here, focusing primarily on vertebrates, we review the current literature on Notch signaling in the nervous system, and highlight numerous recent studies that have generated interesting and unexpected advances.
  7. doi Regulation of caspases in the nervous system implications for functions in health and disease
    Carol M Troy
    Department of Pathology and Cell Biology, Taub Center for the Study of Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, USA
    Prog Mol Biol Transl Sci 99:265-305. 2011
    ..After development, caspases are downregulated in the nervous system, but continue to perform important nonapoptotic functions relevant for neurogenesis and synaptic plasticity...
  8. pmc Neuropathic pain: a maladaptive response of the nervous system to damage
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Annu Rev Neurosci 32:1-32. 2009
    Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its structure and function so that pain occurs spontaneously and responses to noxious and innocuous stimuli are pathologically amplified...
  9. ncbi Ambra1 regulates autophagy and development of the nervous system
    Gian Maria Fimia
    National Institute for Infectious Diseases, IRCCS L Spallanzani, 00149 Rome, Italy
    Nature 447:1121-5. 2007
    ....
  10. doi Regulation of terminal differentiation programs in the nervous system
    Oliver Hobert
    Howard Hughes Medical Institute, New York, NY 10032, USA
    Annu Rev Cell Dev Biol 27:681-96. 2011
    The generation of individual neuron types in the nervous system is a multistep process whose endpoint is the expression of neuron type-specific batteries of terminal differentiation genes that determine the functional properties of a ..
  11. pmc Prenatal exposure to PBDEs and neurodevelopment
    Julie B Herbstman
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, Columbia Center for Children s Environmental Health, New York, New York 10032, USA
    Environ Health Perspect 118:712-9. 2010
    ..Animal studies suggest that prenatal PBDE exposure may result in adverse neurodevelopmental effects...
  12. doi Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
    Antoine Taly
    Laboratoire de Chimie Biophysique, Institut de Science et d Ingenierie Supramoleculaires, UMR 7006 CNRS Université de Strasbourg, 8 allee Gaspard Monge, 67000 Strasbourg, France
    Nat Rev Drug Discov 8:733-50. 2009
    ....
  13. ncbi The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans
    E M Hedgecock
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110
    Neuron 4:61-85. 1990
    ..These genes probably identify molecular cues on the basal lamina that guide mesodermal migrations. The same basal lamina cues, or perhaps related molecules on the epidermal cell surfaces, guide pioneer neurons...
  14. ncbi Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
    L Luo
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco 94143
    Genes Dev 8:1787-802. 1994
    ..They share 70% amino acid sequence identity with each other, and both are highly expressed in the nervous system and mesoderm during neuronal and muscle differentiation, respectively...
  15. pmc UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles
    M L Nonet
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Biol Cell 10:2343-60. 1999
    ..The UNC-11 protein is expressed at high levels in the nervous system and at lower levels in other tissues...
  16. ncbi Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system
    Jean Livet
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 450:56-62. 2007
    ..The ability of the Brainbow system to label uniquely many individual cells within a population may facilitate the analysis of neuronal circuitry on a large scale...
  17. ncbi Apoptosis in the nervous system
    J Yuan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 407:802-9. 2000
    ..Elucidation of the cell death machinery in neurons promises to provide multiple points of therapeutic intervention in neurodegenerative diseases...
  18. pmc Herpesvirus transport to the nervous system and back again
    Gregory Smith
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Annu Rev Microbiol 66:153-76. 2012
    ..These viruses efficiently invade the peripheral nervous system and establish lifelong latency in neurons resident in peripheral ganglia...
  19. doi The single dendritic branch as a fundamental functional unit in the nervous system
    Tiago Branco
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Curr Opin Neurobiol 20:494-502. 2010
    ..the notion that the single dendritic branch may represent a fundamental unit of signalling in the mammalian nervous system. This view proposes that the dendritic branch is a basic organizational unit for integrating synaptic input, ..
  20. pmc Exosomal transfer of proteins and RNAs at synapses in the nervous system
    Neil R Smalheiser
    University of Illinois Chicago, UIC Psychiatric Institute MC912, 1601 W, Taylor Street, Chicago, IL 60612, USA
    Biol Direct 2:35. 2007
    ..Exosomes express cell recognition molecules on their surface that facilitate their selective targeting and uptake into recipient cells...
  21. ncbi Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development
    Katsunori Nakata
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064, USA
    Cell 120:407-20. 2005
    ..DLK-1 protein levels are elevated in rpm-1 mutants. The RPM-1 RING finger can stimulate ubiquitination of DLK-1. Our data reveal a presynaptic role of a previously unknown p38 MAP kinase cascade...
  22. ncbi Polysialic acid in the plasticity of the developing and adult vertebrate nervous system
    Urs Rutishauser
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Neurosci 9:26-35. 2008
    ..regulation has direct effects on several cellular mechanisms that underlie the formation of the vertebrate nervous system, most conspicuously in the migration and differentiation of progenitor cells and the growth and targeting of ..
  23. ncbi Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice
    L Aigner
    Friedrich Miescher Institute, Basel, Switzerland
    Cell 83:269-78. 1995
    ..A mutant GAP-43 that cannot be phosphorylated by PKC had reduced sprout-promoting activity. The results establish GAP-43 as an intrinsic presynaptic determinant for neurite outgrowth and plasticity...
  24. doi Anatomy and development of the nervous system of Nematostella vectensis, an anthozoan cnidarian
    Heather Q Marlow
    Kewalo Marine Laboratory, Pacific Biomedical Research Center, University of Hawaii, Honolulu, Hawaii 96813, USA
    Dev Neurobiol 69:235-54. 2009
    ..N. vectensis' nervous system is a diffuse nerve net with both ectodermal sensory and effector cells and endodermal multipolar ganglion ..
  25. pmc Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system
    M Maduro
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Genetics 141:977-88. 1995
    ..Expression of an unc-119/lacZ fusion in transgenic animals is seen in many neurons, suggesting that the unc-119 mutant phenotype is due to a defect in the nervous system.
  26. ncbi Neural induction: old problem, new findings, yet more questions
    Claudio D Stern
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 132:2007-21. 2005
    ..This review summarizes neural induction events in different species and highlights some unanswered questions about this important developmental process...
  27. pmc Aquaporin water channels in the nervous system
    Marios C Papadopoulos
    Academic Neurosurgery Unit, St George s, University of London, Tooting, London, SW17 0RE, UK ac uk
    Nat Rev Neurosci 14:265-77. 2013
    ....
  28. doi Matrix metalloproteinase-2 and -9 as promising benefactors in development, plasticity and repair of the nervous system
    Mieke Verslegers
    Laboratory of Neural Circuit Development and Regeneration, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Leuven, Belgium
    Prog Neurobiol 105:60-78. 2013
    ..most prominently in the field of cancer metastasis, and more recent investigations also focus on the nervous system, with a striking emphasis on the gelatinases, MMP-2 and MMP-9...
  29. pmc Alphavirus-induced encephalomyelitis: antibody-secreting cells and viral clearance from the nervous system
    Talibah U Metcalf
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Virol 85:11490-501. 2011
    Sindbis virus (SINV) infection of the central nervous system (CNS) provides a model for understanding the role of the immune response in recovery from alphavirus infection of neurons...
  30. doi MicroRNA function in the nervous system
    Roberto Fiore
    Interdisziplinäres Zentrum für Neurowissenschaften, SFB488 Junior Group, Universitat Heidelberg, and Institut für Neuroanatomie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 345, Heidelberg, Germany
    Prog Mol Biol Transl Sci 102:47-100. 2011
    ..In this chapter, we summarize our current knowledge of miRNA functions during neuronal development, physiology, and dysfunction...
  31. pmc Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system
    Marton Lorant Toth
    Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 32:8778-90. 2012
    ..In the aging nematode nervous system, neuronal death and/or detectable loss of processes are not readily apparent, but because dendrite ..
  32. doi Role and therapeutic potential of VEGF in the nervous system
    Carmen Ruiz de Almodovar
    The Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium
    Physiol Rev 89:607-48. 2009
    ..described as a key angiogenic factor, it is now well established that VEGF also plays a crucial role in the nervous system. We describe the molecular properties of VEGF and its receptors and review the current knowledge of its ..
  33. ncbi Development of the enteropneust Ptychodera flava: ciliary bands and nervous system
    Claus Nielsen
    Zoological Museum, The Natural History Museum of Denmark, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    J Morphol 268:551-70. 2007
    ..Ciliary band development was examined by scanning electron microscopy, and the development of the serotonergic nervous system was followed by means of immunostaining...
  34. ncbi Identification of neurogenin, a vertebrate neuronal determination gene
    Q Ma
    Division of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
    Cell 87:43-52. 1996
    ..The properties of X-NGNR-1 are thus analogous to those of the Drosophila proneural genes, suggesting that it functions as a vertebrate neuronal determination factor...
  35. doi Diverse roles for VEGF-A in the nervous system
    Francesca Mackenzie
    UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London, UK
    Development 139:1371-80. 2012
    ....
  36. pmc Geminin regulates neuronal differentiation by antagonizing Brg1 activity
    Seongjin Seo
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genes Dev 19:1723-34. 2005
    ....
  37. ncbi Mechanisms of action of docosahexaenoic acid in the nervous system
    N Salem
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
    Lipids 36:945-59. 2001
    This review describes (from both the animal and human literature) the biological consequences of losses in nervous system docosahexaenoate (DHA)...
  38. ncbi Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein
    J E Lee
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Science 268:836-44. 1995
    ..The data suggest that neuroD may participate in the terminal differentiation step during vertebrate neuronal development...
  39. doi Functions of Nogo proteins and their receptors in the nervous system
    Martin E Schwab
    University of Zurich and ETH, Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Neurosci 11:799-811. 2010
    ..of Nogo proteins and their receptors--in precursor migration, neurite growth and branching in the developing nervous system--as well as a growth-restricting function during CNS maturation...
  40. ncbi UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues
    S S Chan
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Cell 87:187-95. 1996
    ..Together with the recent report that DCC is a netrin receptor in vertebrates, our results suggest that UNC-40 is a component of UNC-6 receptors on motile cells...
  41. ncbi Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans
    W G Wadsworth
    Department of Pathology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Neuron 16:35-46. 1996
    ..UNC-6 is expressed in 12 types of neuroglia and neurons, creating a hierarchy of netrin cues in the developing nervous system. Comparing gene expression pattern with in vivo phenotypes, we suggest how multiple netrin cues, each with a ..
  42. ncbi Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system
    M Schaefer
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Cell 107:183-94. 2001
    ..Thus, asymmetric activation of heterotrimeric G proteins by a receptor-independent mechanism may orient asymmetric cell divisions in different cell types...
  43. ncbi Disruption of the mouse L1 gene leads to malformations of the nervous system
    M Dahme
    Department of Neurobiology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Nat Genet 17:346-9. 1997
    ..gene are associated with a variable phenotype, including mental retardation and anomalous development of the nervous system, referred to as 'CRASH' (corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraplegia, and ..
  44. pmc NF-kappaB in the nervous system
    Barbara Kaltschmidt
    Molecular Neurobiology, University of Bielefeld, Universitatsstr 25, D 33501 Bielefeld
    Cold Spring Harb Perspect Biol 1:a001271. 2009
    The transcription factor NF-kappaB has diverse functions in the nervous system, depending on the cellular context. NF-kappaB is constitutively activated in glutamatergic neurons...
  45. ncbi EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins
    M R Koelle
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 84:115-25. 1996
    ..Two previously known and 13 newly identified mammalian genes have similarity to egl-10 and SST2, and we propose that members of this family regulate many G protein signaling pathways...
  46. doi Post-translational modifications of tubulin in the nervous system
    Nobuyuki Fukushima
    Department of Life Science, Kinki University, Higashiosaka, Japan
    J Neurochem 109:683-93. 2009
    ..Here we review current exciting topics that are expected to advance MT research in the nervous system.
  47. ncbi Alternative RNA splicing in the nervous system
    P J Grabowski
    Department of Biological Sciences, Howard Hughes Medical Institute, A507LH, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA
    Prog Neurobiol 65:289-308. 2001
    ..profoundly effects animal physiology, development and disease, and this is nowhere more evident than in the nervous system. Alternative splicing is a versatile form of genetic control whereby a common pre-mRNA is processed into ..
  48. ncbi Function and regulation of CREB family transcription factors in the nervous system
    Bonnie E Lonze
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 35:605-23. 2002
    ..In this review, we focus on the current level of understanding of where, when, and how CREB family members function in the nervous system.
  49. pmc mTOR: on target for novel therapeutic strategies in the nervous system
    Kenneth Maiese
    Laboratory of Cellular and Molecular Signaling, Cancer Center, New Jersey Health Sciences University, Newark, NJ 07101, USA
    Trends Mol Med 19:51-60. 2013
    ..Targeting mTOR in the nervous system can offer exciting new avenues of drug discovery, but crucial to this premise is elucidating the complexity of ..
  50. pmc A novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous system
    Fouad El-Shehabi
    Institute of Parasitology, McGill University, Sainte Anne de Bellevue, Quebec, Canada
    PLoS Negl Trop Dis 6:e1523. 2012
    Schistosomes have a well developed nervous system that coordinates virtually every activity of the parasite and therefore is considered to be a promising target for chemotherapeutic intervention...
  51. doi The mechanical control of nervous system development
    Kristian Franze
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
    Development 140:3069-77. 2013
    The development of the nervous system has so far, to a large extent, been considered in the context of biochemistry, molecular biology and genetics...
  52. doi A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system
    Leonora Buzanska
    NeuroRepair Department, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Stem Cells 27:2591-601. 2009
    ..Although not exhaustive, this work shows that the HUCB-NSC model fulfils these criteria and may serve as a human in vitro model for DNT priority setting...
  53. pmc Noise in the nervous system
    A Aldo Faisal
    Computational and Biological Learning Lab, Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ, UK
    Nat Rev Neurosci 9:292-303. 2008
    ..However, the nature, amount and impact of noise in the nervous system have only recently been addressed in a quantitative manner...
  54. ncbi Multicolor "DiOlistic" labeling of the nervous system using lipophilic dye combinations
    W B Gan
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 27:219-25. 2000
    We describe a technique for rapid labeling of a large number of cells in the nervous system with many different colors...
  55. ncbi Differential sulfations and epimerization define heparan sulfate specificity in nervous system development
    Hannes E Bülow
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032 USA
    Neuron 41:723-36. 2004
    ..Our results demonstrate that the molecular diversity in HS encodes information that is crucial for different aspects of neuronal development...
  56. doi Neuroanatomy of Halobiotus crispae (Eutardigrada: Hypsibiidae): Tardigrade brain structure supports the clade Panarthropoda
    Dennis K Persson
    Invertebrate Department, Natural History Museum of Denmark, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen Ø, Denmark
    J Morphol 273:1227-45. 2012
    ..In this article, we present a detailed description of the nervous system of the eutardigrade Halobiotus crispae, using immunostainings, confocal laser scanning microscopy, and ..
  57. doi Agarose hydrogel microcompartments for imaging sleep- and wake-like behavior and nervous system development in Caenorhabditis elegans larvae
    Henrik Bringmann
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    J Neurosci Methods 201:78-88. 2011
    ..We show that worms cultured inside hydrogel microcompartments develop into normal adults. Thus, hydrogel microcompartments appear useful for long-term observation of larval behavior and development...
  58. pmc Guidance receptor degradation is required for neuronal connectivity in the Drosophila nervous system
    W Ryan Williamson
    Department of Physiology and Green Center for Systems Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Biol 8:e1000553. 2010
    ..In contrast, receptor missorting occurs sufficiently early in neurons of the adult central nervous system to cause connectivity defects...
  59. ncbi Vitamin B12, folic acid, and the nervous system
    Edward Reynolds
    Institute of Epileptology, King s College, Denmark Hill Campus, Cutcombe Road, London, SE5 6PJ, UK
    Lancet Neurol 5:949-60. 2006
    ..Folic acid and vitamin B12 may have roles in the prevention of disorders of CNS development, mood disorders, and dementias, including Alzheimer's disease and vascular dementia in elderly people...
  60. doi Programmed cell death during postnatal development of the rodent nervous system
    Woon Ryoung Kim
    Department of Anatomy, Korea University College of Medicine, Brain Korea 21, Anam Dong, Sungbuk Gu, Seoul 136 705, Korea
    Dev Growth Differ 53:225-35. 2011
    ..of excess cells through programmed cell death (PCD) is essential for the establishment and maintenance of the nervous system. In many brain regions, development and major histogenesis continue beyond postnatal stages, and therefore, ..
  61. pmc Foundational model of structural connectivity in the nervous system with a schema for wiring diagrams, connectome, and basic plan architecture
    Larry W Swanson
    Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 107:20610-7. 2010
    The nervous system is a biological computer integrating the body's reflex and voluntary environmental interactions (behavior) with a relatively constant internal state (homeostasis)-- promoting survival of the individual and species...
  62. pmc Developmental regulation of axon branching in the vertebrate nervous system
    Daniel A Gibson
    Zilkha Neurogenetic Institute, Department of Cell and Neurobiology, Keck School of Medicine, Neuroscience Graduate Program, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089, USA
    Development 138:183-95. 2011
    During nervous system development, axons generate branches to connect with multiple synaptic targets...
  63. doi Conditional inactivation of androgen receptor gene in the nervous system: effects on male behavioral and neuroendocrine responses
    Kalina Raskin
    Centre National de la Recherche Scientifique CNRS Unité Mixte de Recherche UMR 7148, Génétique Moléculaire Neurophysiologie et Comportement, and Institut de Biologie, College de France, Paris, France
    J Neurosci 29:4461-70. 2009
    ..this question, we generated, by using Cre-loxP technology, mice selectively lacking AR expression in the nervous system. The mutant male urogenital tract was normally developed, and mice were able to produce offspring...
  64. ncbi Steroid hormones and neurosteroids in normal and pathological aging of the nervous system
    M Schumacher
    INSERM U488, 80 rue du General Leclerc, Kremlin Bicêtre 94276, France
    Prog Neurobiol 71:3-29. 2003
    ..therapeutical opportunities for promoting successful aging because of their pleiotropic effects in the nervous system: they regulate main neurotransmitter systems, promote the viability of neurons, play an important role in ..
  65. ncbi Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination
    Michael Schumacher
    INSERM U488, 80 rue du General Leclerc, 94276 Kremlin Bicêtre, France
    Growth Horm IGF Res 14:S18-33. 2004
    ..local de novo synthesis as cytochrome P450scc, which converts cholesterol to pregnenolone, is expressed in the nervous system. Pregnenolone is converted to PROG by 3beta-hydroxysteroid dehydrogenase (3beta-HSD)...
  66. ncbi Autoregulation and multiple enhancers control Math1 expression in the developing nervous system
    A W Helms
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Development 127:1185-96. 2000
    Development of the vertebrate nervous system requires the actions of transcription factors that establish regional domains of gene expression, which results in the generation of diverse neuronal cell types...
  67. ncbi The role of BETA2/NeuroD1 in the development of the nervous system
    Jang Hyeon Cho
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Neurobiol 30:35-47. 2004
    ..bHLH) transcription factor family, which has been shown to play a major role in development of the nervous system and formation of the endocrine system...
  68. doi Functional versatility of transcription factors in the nervous system: the SRF paradigm
    Bernd Knöll
    Neuronal Gene Expression Laboratory, Eberhard Karls University Tubingen, Interfaculty Institute for Cell Biology, Department of Molecular Biology, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Trends Neurosci 32:432-42. 2009
    ..gene, encoding the transcription factor serum response factor (SRF), revealed numerous SRF functions in the nervous system. First, SRF controls immediate early gene (IEG) activation associated with perception of synaptic activity, ..
  69. ncbi Homeostatic plasticity in the developing nervous system
    Gina G Turrigiano
    Department of Biology and Volen National Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Neurosci 5:97-107. 2004
  70. pmc XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
    Claudio Hetz
    Institute of Biomedical Sciences, The FONDAP Center for Molecular Studies of the Cell CEMC and the Millennium Nucleus for Neural Morphogenesis NEMO, University of Chile, Santiago, Chile
    Genes Dev 23:2294-306. 2009
    ..these observations in vivo, we generated mutant SOD1 transgenic mice with specific deletion of XBP-1 in the nervous system. XBP-1-deficient mice were more resistant to developing disease, correlating with increased levels of ..
  71. ncbi Role of mTOR in physiology and pathology of the nervous system
    Lukasz Swiech
    Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland
    Biochim Biophys Acta 1784:116-32. 2008
    ..Recent studies reveal that mTOR activity is modified in various pathologic states of the nervous system, including brain tumors, tuberous sclerosis, cortical displasia and neurodegenerative disorders such as ..
  72. doi Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mec
    Alejandro M S Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Comp Biochem Physiol C Toxicol Pharmacol 153:191-222. 2011
    ....
  73. pmc Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer
    J Price
    Proc Natl Acad Sci U S A 84:156-60. 1987
    We describe a cell-lineage marking system applicable to the vertebrate nervous system. The basis of the technique is gene transfer using the retroviral vector system...
  74. ncbi Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis
    S Krauss
    Department of Microbiology, University of Tromsø, Norway
    Development 113:1193-206. 1991
    ..The characteristic expression pattern of pax[zf-b] in the neural tube suggests an involvement of this gene in the regionalization of the midbrain as well as in the specification of neuronal cell fates at early embryonic stages...
  75. ncbi New insights into the diversity and function of neuronal immunoglobulin superfamily molecules
    Genevieve Rougon
    Laboratoire NMDA CNRS UMR 6156, Universite de la Mediterranee, Institut de Biologie du Developpement IBDM, Marseille Cedex 9, 13288 France
    Annu Rev Neurosci 26:207-38. 2003
    ..of recent findings on the diversity and the role of transmembrane and secreted members of IgSF proteins in the nervous system. We illustrate that the complexity of IgSF protein function results from various different levels of ..
  76. ncbi Adaptive roles of programmed cell death during nervous system development
    Robert R Buss
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Annu Rev Neurosci 29:1-35. 2006
    ..the putative adaptive functions of PCD in the animal kingdom with a major focus on PCD in the developing nervous system. Considerable evidence is consistent with the role of PCD in events ranging from neurulation and ..
  77. pmc Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues
    Thomas D Goldman
    Section of Molecular and Computational Biology, Department of Biological Sciences, University of Southern California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 3:e216. 2007
    ..of reproductive behaviors and physiology, we identified genes expressed in the adult head and central nervous system that are regulated downstream of sex-specific transcription factors encoded by doublesex (dsx) and fruitless (..
  78. ncbi Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system
    Jens Husemann
    Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
    Glia 40:195-205. 2002
    ....
  79. pmc Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system
    Michael Jensen
    Department of Biology, University of Utah, Salt Lake City, UT 84112 0840, USA
    Cell 149:173-87. 2012
    The adult nervous system is plastic, allowing us to learn, remember, and forget. Experience-dependent plasticity occurs at synapses--the specialized points of contact between neurons where signaling occurs...
  80. ncbi A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system
    Juha Lauren
    Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, P O Box 56 Viikinkaari 9, FIN 00014 Helsinki, Finland
    Genomics 81:411-21. 2003
    ..proteins are involved in protein-protein interactions and they regulate numerous cellular events during nervous system development and disease...
  81. pmc Neural stem cell transcriptional networks highlight genes essential for nervous system development
    Tony D Southall
    The Gurdon Institute and The Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    EMBO J 28:3799-807. 2009
    ..We also show that multiply bound loci are enriched for genes previously linked to nervous system phenotypes, thereby providing a shortcut to identifying genes important for nervous system development.
  82. pmc The evolution of nervous system patterning: insights from sea urchin development
    Lynne M Angerer
    National Institute for Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Development 138:3613-23. 2011
    Recent studies of the sea urchin embryo have elucidated the mechanisms that localize and pattern its nervous system. These studies have revealed the presence of two overlapping regions of neurogenic potential at the beginning of ..
  83. ncbi Rac function and regulation during Drosophila development
    Satoko Hakeda-Suzuki
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 416:438-42. 2002
    ..Different Rac activators thus act in different developmental processes. The specific cellular response to Rac activation may be determined more by the upstream activator than the specific Rac protein involved...
  84. ncbi Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase
    Kerstin Piechotta
    Department of Anesthesiology and Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 278:52848-56. 2003
    ..These findings suggest that cation-chloride cotransporters might act as "sensors" for cellular stress, and SPAK, by interacting with the cotransporter, serves as an intermediate in the response to cellular stress...
  85. pmc Neurotoxicity of brominated flame retardants: (in)direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system
    Milou M L Dingemans
    Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 119:900-7. 2011
    ..Because this raises concern about adverse effects on the developing brain, we reviewed the scientific literature on these mechanisms...
  86. ncbi Identification of self-replicating multipotent progenitors in the embryonic nervous system by high Notch activity and Hes5 expression
    Onur Basak
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, 79108 Freiburg, Germany
    Eur J Neurosci 25:1006-22. 2007
    ..mammalian neurogenesis are central to understanding the complex mechanisms that govern development of the nervous system. Notch signalling plays a pivotal role in the development of the mammalian nervous system by maintaining ..
  87. doi EdU, a new thymidine analogue for labelling proliferating cells in the nervous system
    Fatemah Chehrehasa
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cellular and Molecular Therapies, Griffith University, Brisbane, QLD 4111, Australia
    J Neurosci Methods 177:122-30. 2009
    ..It is quick and easy and compatible with multiple probes for fluorescence immunochemistry, facilitating the characterisation of proliferating cells at high resolution...
  88. ncbi Responding to DNA double strand breaks in the nervous system
    Y Lee
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 323 North Lauderdale, Memphis, TN 38105, USA
    Neuroscience 145:1365-74. 2007
    Within the nervous system appropriate responses to DNA damage are required to maintain homeostasis and prevent disease...
  89. pmc Regulation of non-coding RNA networks in the nervous system--what's the REST of the story?
    Irfan A Qureshi
    Rosyln and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurosci Lett 466:73-80. 2009
    ..and non-coding RNAs (ncRNAs) are emerging as key regulators that seem to orchestrate almost every aspect of nervous system development, homeostasis, and plasticity...
  90. ncbi Bone morphogenetic protein signalling and vertebrate nervous system development
    Aimin Liu
    Department of Pediatrics, Section of Developmental Biology, University of Colorado at Denver and Health Sciences Center, 12800 East 19th Avenue, Mailstop 8322, P O Box 6511, Aurora, Colorado 80045, USA
    Nat Rev Neurosci 6:945-54. 2005
    ..highlight the interactions between different developmental signals that are necessary to form a functional nervous system. The challenges ahead will be to uncover functions of TGFbeta signalling in later stages of CNS development, ..
  91. ncbi Neural induction by the secreted polypeptide noggin
    T M Lamb
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Science 262:713-8. 1993
    ..Noggin induces cement glands and anterior brain markers, but not hindbrain or spinal cord markers. Thus, noggin has the expression pattern and activity expected of an endogenous neural inducer...
  92. ncbi Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery
    N D Mazarakis
    Oxford BioMedica UK Ltd, Medawar Centre, The Oxford Science Park, Oxford OX4 4GA, UK
    Hum Mol Genet 10:2109-21. 2001
    ..Long-term expression was observed after gene transfer in the nervous system and a minimal immune response which, together with the possibility of non-invasive administration, greatly ..
  93. ncbi The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans
    Kang Shen
    Department of Anatomy, Howard Hughes Medical Institute, Box 0452, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 112:619-30. 2003
    During nervous system development, neurons form reproducible synapses onto specific targets. Here, we analyze the development of stereotyped synapses of the C. elegans HSNL neuron in vivo...
  94. ncbi Histone deacetylases: focus on the nervous system
    B E Morrison
    Department of Molecular and Cell Biology, University of Texas at Dallas, 2601 N Floyd Rd, Richardson, TX 75080, USA
    Cell Mol Life Sci 64:2258-69. 2007
    ..The purpose of this review is to detail work involving the use of HDAC inhibitors within the context of neurodegeneration and examine the roles of individual HDAC members in the nervous system with specific focus on neuronal cell death.
  95. ncbi Epigenetic mechanisms and gene networks in the nervous system
    Christine M Colvis
    Division of Basic Neurosciences and Behavioral Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 25:10379-89. 2005
  96. ncbi Transferrin receptor is necessary for development of erythrocytes and the nervous system
    J E Levy
    Children s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 21:396-9. 1999
    ..Mice lacking Trfr have a more severe phenotype than hpx mice, affecting both erythropoiesis and neurologic development. Furthermore, haploinsufficiency for Trfr results in impaired erythroid development and abnormal iron homeostasis...
  97. ncbi Hydrogen sulfide and nervous system regulation
    Cheng Fang Zhou
    Department of Physiology, Institute of Cognition and Nervous Systems Disease, Medical College, University of South China, Hengyang, Hunan 421001, China
    Chin Med J (Engl) 124:3576-82. 2011
    ....
  98. pmc Co-ordination of cell cycle and differentiation in the developing nervous system
    Christopher Hindley
    Department of Oncology, University of Cambridge, Hutchison Medical Research Council MRC Research Centre, Cambridge CB2 0XZ, U K
    Biochem J 444:375-82. 2012
    ..The present review will summarise our current understanding of the mechanisms co-ordinating the cell cycle and differentiation in the developing nervous system, where these links have been, perhaps, most extensively studied.
  99. pmc Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells
    L Zhou
    Biology Department, University of Massachusetts at Amherst, Amherst, MA 01003, USA
    Proc Natl Acad Sci U S A 94:5131-6. 1997
    ..understand how cells are killed by these genes, we have utilized a well defined set of embryonic central nervous system midline cells that normally exhibit a specific pattern of glial cell death...
  100. doi Caspase-3 in the central nervous system: beyond apoptosis
    Marcello D'Amelio
    Istituto di Ricovero e Cura a Carattere Scientifico, S Lucia Foundation, Via del Fosso di Fiorano 65, 00143 Rome, Italy
    Trends Neurosci 35:700-9. 2012
    ..This protease plays a central role in the developing nervous system and its activation is observed early in neural tube formation and persists during postnatal differentiation of ..
  101. doi Subtypes of glial cells in the Drosophila embryonic ventral nerve cord as related to lineage and gene expression
    Ruth M Beckervordersandforth
    Institute of Genetics, University of Mainz, Saarstrasse 21, D 55122 Mainz, Germany
    Mech Dev 125:542-57. 2008
    ..We demonstrate this by the analysis of a castor loss of function mutation, which affects the number and migration of specific glial cells...

Research Grants114 found, 100 shown here

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..eye, mucous membranes, and other body organs such as the joints, intestinal tract, blood vessels, and central nervous system. Objectives: The purpose of this study is to see how genes affect Beh et's disease and if there are ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..eye, mucous membranes, and other body organs such as the joints, intestinal tract, blood vessels, and central nervous system. Objectives: The purpose of this study is to see how genes affect Beh et's disease and if there are ..
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  5. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  6. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..mechanisms, ususally initiated by trauma or inflammation, "take on a life of their own" as diseases of the nervous system, uncoupled from ongoing tissue injury...
  7. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..a congenital defect that affects 1 out of 5,000 live births and is characterized by a failure to form enteric nervous system (ENS) in a variable length of the hindgut ADDIN EN...
  8. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..felt to underlie the association between OSA and adverse cardiovascular sequellae is heightened sympathetic nervous system activity stemming from repetitive apneic events, although falls in cardiac output that accompany large ..
  9. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    ..EAE is an inflammatory demyelinating disease of the central nervous system with a critical genetic component...
  10. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..Pathophysiologic mechanisms that could explain these associations such as autonomic nervous system dysfunction, endothelial dysfunction, inflammation, and insulin resistance have been identified in the setting ..
  11. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..Our basic research seeks to understand the central nervous system mechanisms implicated in the effects of asphyxia on the cardiovascular and respiratory systems during sleep...
  12. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..Agrin-dependent regulation of the a3 pump modulates excitability of central nervous system neurons, as well as the levels of cytoplasmic calcium and other second messengers implicated in regulating ..
  13. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..women smoke, and their offspring have a higher than normal incidence of impaired cardiac function, autonomic nervous system disorders, sleep disorders, delayed speech and central and obstructive apneas...
  14. MOLECULAR BASIS OF INSULIN RESISTANCE
    Maureen J Charron; Fiscal Year: 2010
    ..of whole body glucose homeostasis as it integrates signals from the gut, peripheral tissue and central nervous system. This process is disrupted in diseases such as TD2M and the Metabolic Syndrome...
  15. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..While the role of vascular CGRP receptors is well recognized, the role of nervous system CGRP receptors in blood pressure regulation remains unclear...
  16. MOLECULAR BASIS OF REOVIRUS PATHOGENESIS
    Terence S Dermody; Fiscal Year: 2013
    ..intestinal mucosa, disseminates via hematogenous or neural routes, and targets the heart, liver, and central nervous system (CNS) to cause disease...
  17. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..in animals and humans suggest that sleep deprivation leads to changes in hormones and increased sympathetic nervous system (SNS) function amongst other effects...
  18. Neuroprotection and Myelin Repair Mechanisms in Multiple Sclerosis
    Inderjit Singh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multiple sclerosis (MS) is central nervous system (CNS) inflammatory, demyelinating disease that affects individuals in their most productive ages...
  19. Systemic Inflammation and Central Nervous System Dysfunction
    Laura L Dugan; Fiscal Year: 2013
    ..abstract_text> ..
  20. A unique approach to identify markers for congenital syphilis and neurosyphilis
    Nikhat Parveen; Fiscal Year: 2010
    ..Invasion of the placenta, which may lead to congenital transmission and of the central nervous system will be detectable in mice by an in vivo imaging system (IVIS 200)...
  21. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..Omega-3 fatty acids (docosahexaenoic acid-DHA particularly), are uniquely concentrated in the central nervous system and are involved in neuroprotection, cognition, and other brain and retinal functions...
  22. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..Far from being neutral glue of the nervous system, glia are heterogeneous, active players in axonal pathfinding, synapse formation and signal transmission ..
  23. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..Recently, we have begun to explore the relationship between virus infection in the nervous system (peripheral and central) and the role of the type I IFN system in local host resistance and the ensuing ..
  24. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..Current therapy for hypertension and heart failure, in large part, target the sympathetic nervous system and the renin- angiotensin II system (RAS)...
  25. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..Synapses are initially formed during development of the nervous system, and formation of appropriate synapses is crucial for establishment of neuronal circuits that underlie ..
  26. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
    ..specific Challenge Topics: 15-NS-101* Manipulating the blood-brain-barrier to deliver CNS therapies for Mental/Nervous System Disorders;06-GM-102* Chemist/biologist collaborations facilitating tool development;05-AG-103* Imaging and ..
  27. Chemical modulators of Tet-family proteins
    Anjana Rao; Fiscal Year: 2010
    ..In cancer, DNA methylation has been linked to aberrant silencing of tumor suppressor genes;in the central nervous system (CNS), it has been implicated, among other things, in learning, memory and synaptic plasticity...
  28. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
    ..Because increases in the sympathetic nervous system (SNS) activity are necessary to increase BAT thermogenesis and WAT lipolysis, I will test how centrally-acting ..
  29. Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic Acids
    TIMOTHY L SITA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system malignancy...
  30. The Role of Interleukin-10 During Fatal Alphavirus Encephalomyelitis
    KIRSTEN KULCSAR; Fiscal Year: 2013
    ..The proposed research is aimed at determining the role IL-10 has in the central nervous system during fatal viral encephalitis...
  31. Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
    Michelle A Williams; Fiscal Year: 2013
    ..Furthermore, evidence suggests that transient activation of the sympathetic nervous system might trigger AP...
  32. Genetics of the Neuromuscular Junction: Mechanisms and Disease Models
    Robert W Burgess; Fiscal Year: 2013
    ..is to understand how dominant mutations in tRNA synthetase genes cause axonal degeneration in the peripheral nervous system. Mutations in glycyl tRNA synthetase (GARS) and tyrosyl tRNA synthetase (YARS) cause Charcot-Marie-Tooth type ..
  33. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..BZs can cause depressing (agonist) or stimulating (inverse agonist) effects on the central nervous system by modulating the GABAA receptor, the most prevalent inhibitory receptor within the brain...
  34. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..NTs): growth factors including brain-derived neurotrophic factor (BDNF) known for their diverse roles in the nervous system. NTs and their receptors have now been found in different lung components including airway smooth muscle (ASM),..
  35. Characterization of epsilon-sarcoglycan interacting proteins in mouse brain
    Yuqing Li; Fiscal Year: 2012
    ..Dystonia is generally believed to be a disorder of the central nervous system. Inherited myoclonus- dystonia (M-D), previously referred to as hereditary essential myoclonus or hereditary (..
  36. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..e. a change in system performance based on prior experience) of the respiratory and autonomic nervous system. One adaptation that has been shown to manifest itself in animals following exposure to IH is long-term ..
  37. Mechanisms of virus-induced injury in the brain and spinal cord
    Kenneth L Tyler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Viruses induce disease in the central nervous system (CNS) by either killing or disrupting essential functions of neurons within the brain and spinal cord...
  38. Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
    David E Clapham; Fiscal Year: 2013
    ..ion channel subunits comprise 7 distinct gene products (TRPC1-7), most of which are expressed in the central nervous system. Three subfamily members of this class (TRPC1, TRPC4, and TRPC5) are highly expressed in the hippocampus...
  39. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..Although the genes mutated in CMT are also expressed in the central nervous system, the disorder almost never affects brain function...
  40. Dynamics of Kinesins, Dyneins, and Myosins
    Paul R Selvin; Fiscal Year: 2010
    ..as a function of insertion length of the cargo-binding domain of myosin VI (with L. Sweeney, UPenn.). d) Technological developments: Optics/microscopy needs to be achieved to fulfill the above goals. ..
  41. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    ..The current concept is that sympathetic nervous system overactivity and vascular endothelial dysfunction play important roles...
  42. Regulation of Astrocyte TIMP-1 in HIV-Associated Dementia
    JEREL ADAM FIELDS; Fiscal Year: 2011
    ..The disease is characterized by an accumulation of activated and infected macrophages/microglia in the central nervous system, which secrete cytokines, infectious virions and viral proteins that activate surrounding astrocytes leading ..
  43. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2013
    ..are important for an anti-viral immune response, the lasting expression of IFN? in the HIV-1 exposed central nervous system (CNS) has been connected to cognitive impairment and inflammatory neuropathology...
  44. Hormonal regulation of a Ca2+/AMPK signaling pathway
    Anthony R Means; Fiscal Year: 2013
    ..At least part of the protection is mediated via the central nervous system as CaMKK2 functions in neurons of the hypothalamic arcuate nucleus to control production of neuropeptide Y...
  45. Hypothalamic SIRT1 and Energy Balance
    Eduardo A Nillni; Fiscal Year: 2013
    ..At the central level, the hypothalamus is the primary component of the nervous system in interpreting adiposity or nutrient related inputs;it delivers hormonal and behavioral responses with the ..
  46. Mechanisms of Bone Loss from Administration of the Second-Generation Antipsychoti
    KATHERINE JEAN MOTYL; Fiscal Year: 2013
    ..My results will also add to the increasing evidence for a key role of the nervous system in regulating skeletal homeostasis.
  47. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2012
    ..and genetic association studies in Parkinson disease (PD) support the view that PD is a complex systemic nervous system disorder caused by one or more environmental agents acting on genetically vulnerable individuals...
  48. Combined BAC Transgenic and Knock-Out Mouse Model of Lowe Syndrome Nephropathy
    Robert L Nussbaum; Fiscal Year: 2013
    ..Finally, after completing a 10-generation backcross onto C57Bl/6, we will examine the mice for abnormalities in central nervous system by testing motor function, anxiety, learning, memory and by examining the brains neuropathologically.
  49. Study of zidovudine addition in HIV-associated neurocognitive disorders
    Albert Anderson; Fiscal Year: 2013
    ..aims to become a leader in human immunodeficiency virus (HIV) clinical research with a focus on the central nervous system (CNS) involvement of HIV...
  50. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2011
    ..e. its effect on cholesterol homeostasis in the central nervous system. While too much cholesterol may be deleterious, as in case of atherosclerosis and Alzheimer's disease, ..
  51. The function of ATM protein in the biology of the adult neuron CNS:
    Karl Herrup; Fiscal Year: 2013
    ..The core hypothesis of this application is that there is a nervous system-specific form of ATM that is cytoplasmic...
  52. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..neurotrophin, Brain Derived Neurotrophic Factor (BDNF), in the physiology and pathophysiology of the enteric nervous system (ENS) with regard to the regulation of the peristaltic reflex...
  53. Role of Sex Chromosome Complement in the CNS during Autoimmune Disease
    Sienmi Du; Fiscal Year: 2013
    ..Multiple sclerosis (MS) is a putative autoimmune demyelinating disease of the central nervous system (CNS) characterized in the initial stages by inflammation, in the later stages by neurodegeneration, and has a ..
  54. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..NHE-1 over expression;and 3) assess the contribution of NHE-1 to oxidative-nitrosative stress in peripheral nervous system of diabetic rats and high glucose-exposed cultured HSC and co-cultured rat SC and DRG neurons...
  55. Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL Mice
    MELISSA ANN BROWN; Fiscal Year: 2013
    ..provided by applicant): Multiple sclerosis (MS), the most common inflammatory disease of the central nervous system (CNS), affects more than 2.5 million people worldwide...
  56. Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase Deficiency
    Robert H Eckel; Fiscal Year: 2013
    ..LPL is also present throughout the nervous system including neurons in the hippocampus, hypothalamus, and other brain regions...
  57. Neuropeptide modulation of biogenic amine function and aggression in a crustacean
    Maria A Sosa; Fiscal Year: 2013
    ..male morphotypes and aggressive behaviors induced by injection of 5-HT and OA;(2) Characterize the central nervous system (CNS) distribution of these neuropeptides in the prawn morphotypes and determine how it relates with those of ..
  58. 14th International Workshop on Ataxia-Telangiectasia and ATM
    Richard A Gatti; Fiscal Year: 2010
    ..importance of chromatin and genomic instability in the activation of ATM, the role of ATM in the developing nervous system and in neurodegeneration, animal models of A-T, ATM mutations in breast and other human cancers, the ..
  59. Misty: a model for central regulation of bone remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..The central nervous system (CNS) modulates adipose tissue function and bone turnover through efferent pathways from the SNS...
  60. Brain Delivery of Nanoformulated Superoxide Dismutase
    Erin G Rosenbaugh; Fiscal Year: 2013
    ..to increase brain delivery and neuronal uptake of antioxidant proteins may be applicable to other central nervous system disorders associated with elevated levels of reactive oxygen species, including Alzheimer's disease, ..
  61. Parental age at birth and risk of adult-onset cancer in female offspring
    Yani Lu; Fiscal Year: 2013
    ..at birth is associated with childhood and adolescent disorders such as schizophrenia, childhood leukemias and nervous system tumors...
  62. Role of Dendritic Ca2+ Transients in Respiratory Rhythm Generation
    Jack L Feldman; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: In humans, continuous breathing from birth is essential to life and requires that the nervous system generate a reliable and robust rhythm that drives inspiratory and expiratory muscles...
  63. MECHANISMS OF DENDRITE MORPHOGENESIS BY THE ANAPHASE-PROMOTING COMPLEX
    ALBERT HONG JAE KIM; Fiscal Year: 2013
    ..Jeff Milbrandt, whose laboratory focuses on elucidating mechanisms of gene regulation during nervous system development...
  64. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..Chromaffin cells are an important neuroendocrine component of the sympathetic nervous system that release a cocktail of catecholamines, peptides, and others transmitters to ensure coordinated ..
  65. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..It is a chronic disease characterized by inflammation in the central nervous system that results in neuron demyelination leading to paralysis...
  66. Nanomedicine and NeuroAIDS
    Howard E Gendelman; Fiscal Year: 2013
    ..Drug toxicities, patient compliance and limited penetrance into viral reservoirs (notably the central nervous system (CNS), gut and lymphatic organs) have diminished long-term antiretroviral therapy (ART) efficacy for HIV ..
  67. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2013
    ..If untreated, Lyme disease can lead to a wide array of complications typically involving the heart, joints, or nervous system. It is widely believed that the motility of B. burgdorferi is essential for the pathogenesis of Lyme disease...
  68. Glial-neuronal interactions underlying the molecular feedback between HIV viral p
    Sulie L Chang; Fiscal Year: 2013
    ..In the central nervous system (CNS), the glial cells are infected by the HIV-1 virus, causing neuroinflammation...
  69. Combined neuroprotection and metabolic correction to treat leukodystrophies
    ERNESTO ROQUE BONGARZONE; Fiscal Year: 2013
    ..accumulation of galactosylsphingosine (psychosine) in myelin-forming cells, leading to demyelination of the nervous system. To reduce demyelination, current therapies seek to provide the missing enzyme to myelinating glia via ..
  70. Ibuprofen and enteric neural crest precursor migration
    ELLEN MERRICK; Fiscal Year: 2013
    ..Hirschsprung Disease (HSCR) is a birth defect of the enteric nervous system that occurs when enteric neural crest-derived cells (ENCCs) do not migrate all the way to the end of the bowel...
  71. Mapping Orofacial Nociceptive Pathways and Alterations Due to Inflammation
    JOSHUA EMRICK; Fiscal Year: 2013
    ..stimuli activate primary afferent sensory neurons (nociceptors) producing pain via signaling to the central nervous system (CNS) and contributing to inflammation by releasing inflammatory mediators at the site of injury...
  72. Epigenetic mechanisms of TDP43-mediated neurodegeneration
    Amit Berson; Fiscal Year: 2013
    ..been shown to be critical for neuronal function, the roles that such modifications play in maintenance of the nervous system and their contribution to neurodegenerative diseases remain largely unknown...
  73. Analysis of the tumor suppressor gene Tsc1 in motor neuron patterning
    Onanong Chivatakarn; Fiscal Year: 2013
    ..Ultimately, the knowledge gained has the potential to inform how the tumor suppressor gene TSC1 functions in nervous system development and how perturbation of this pathway can cause the neurological manifestations typically observed ..
  74. Role of Central Neural NFkB and ER Stress in Obesity-induced Hypertension
    COLIN NEAL YOUNG; Fiscal Year: 2013
    ..A potential means is by evoking long-term changes in gene expression in central nervous system (CNS) cardiovascular neurons through the activation of inducible transcription factors, including nuclear ..
  75. Viral And host mechanisms that tilt the HSV lytic/latent balance
    Donald M Coen; Fiscal Year: 2013
    ..RELEVANCE: Herpes simplex viruses cause considerable genital, ocular and nervous system disease, and genital herpes increases the risk of HIV infection...
  76. MOUSE MODELS OF INSULIN RESISTANCE
    Domenico Accili; Fiscal Year: 2013
    ..homeostasis;(ii) the discovery of mechanisms by which non-canonical sites of insulin action, such as central nervous system (CNS) and endocrine pancreas, play an early and decisive role in the progression from insulin resistance to ..
  77. Murine coronavirus neurovirulence: role of type I interferon response
    Susan R Weiss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Viral infections of the central nervous system (CNS) can cause both acute and chronic diseases that devastate the host...
  78. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2013
    ..and urocortins [Ucn] 1-3) and their receptors (CRFR1, CRFR2) are essential mediators of stress in the central nervous system. Therefore a systemic inhibition of their function is not an attractive therapeutic model...
  79. Epigenetic regulation in neuropathic pain
    Zhonghui Guan; Fiscal Year: 2013
    ..that the transition from acute to chronic pain following nerve injury reflects a maladaptive plasticity of te nervous system that is manifest at physiological, structural, biochemical and molecular levels...
  80. Cathepsin L in the Biosynthesis of Enkephalins and beta-Endorphin Opioid Peptides
    Steven J Bark; Fiscal Year: 2012
    ..Bark's capabilities to identify and answer important questions about regulation of the nervous system in health and human disease as an independent research scientist...
  81. The role of indolamine2,3-dioxygenase in the host response/pathogenesis of Venezu
    Robert Seymour; Fiscal Year: 2013
    ..The neuropathogenesis of these viruses and the host response of the central nervous system are still not completely understood...
  82. Regulation of B cells in the CNS
    Cornelia Bergmann; Fiscal Year: 2013
    ABSTRACT Antibody (Ab) production and the presence of B cells within the central nervous system (CNS) is well documented in humans with the demyelinating disease multiple sclerosis (MS) and those afflicted by neurotropic infections...
  83. Investigating the mechanism of TNFalpha mediated cell death in oligodendrocytes
    Junying Yuan; Fiscal Year: 2013
    ..MS, an inflammatory demyelinating disease of the central nervous system (CNS), is the most common chronic neurodegenerative disease for young adults during their most productive ages...
  84. Mechanisms of airborne particulate matter induced thrombosis
    Gokhan M Mutlu; Fiscal Year: 2013
    ..that PM-induced alterations in hemostasis resulting from lung inflammation and activation of the sympathetic nervous system play causal roles...
  85. Air pollution and the brain: gender as an important determinant of susceptibility
    Lucio G Costa; Fiscal Year: 2013
    ..established;in addition, initial evidence suggests that air pollution may also negatively affect the central nervous system (CNS) and contribute to CNS diseases...
  86. The role of diet-induced obesity in cognitive impairment
    CATRINA SIMS ROBINSON; Fiscal Year: 2013
    ..Studies have demonstrated that improving insulin signaling in the central nervous system (CNS) has a positive impact on cognition;however, obese individuals are excluded from such studies...
  87. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    Gamma frequency oscillations (30-90 Hz) are found in many parts of the nervous system, including the hippocampus, neocortex, entorhinal cortex and amygdala...
  88. miR132 regulation of neuronal plasticity, learning, and memory
    KATELIN L F HANSEN; Fiscal Year: 2013
    ..Thus, the functional role of miRNAs in nervous system physiology and cognition merits close examination...
  89. Glypican-1 in gliomagenesis
    Andreas Friedl; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Central nervous system gliomas cause morbidity and mortality by relentless growth and local invasion. High-grade gliomas typically kill patients within months after diagnosis...
  90. The Molecular Genetics of Early Neurogenesis
    Ethan Bier; Fiscal Year: 2013
    ..during neural induction to establish the dorsal-ventral (DV) axis and to distinguish epidermal from central nervous system cell fates...
  91. Control of Breathing and Pompe Disease
    David D Fuller; Fiscal Year: 2013
    ..disease - intravenous enzyme replacement therapy (ERT) using recombinant GAA - does not target the central nervous system (CNS)...
  92. Methylmercury exposure, mercury metabolism genotypes, and risk of adult glioma
    Kathleen M Egan; Fiscal Year: 2013
    ..The central nervous system is highly susceptible to the toxic effects of MeHg since the compound is able to cross the blood-brain barrier ..
  93. Small-molecule probes of chromatin-mediated neuroplasticity
    Stephen J Haggarty; Fiscal Year: 2013
    ..novel therapeutics based upon this knowledge is critical in order to improve the treatment and prevention of nervous system disorders...
  94. Adhesion Mechanisms Mediating Sickle Cell Vasooclusion In Vivo
    Paul S Frenette; Fiscal Year: 2013
    ..Preliminary data indicate that circadian adrenergic signals are locally delivered by nerves of the sympathetic nervous system (SNS)...
  95. Central Nervous System Mechanisms in Knee Osteoarthritis (KOA)
    Daniel J Clauw; Fiscal Year: 2013
    ..to pain and symptom expression in KOA, some patients possess varying degrees of non-psychological central nervous system (CNS) factors which play an equally or even more prominent role in the expression of pain and co-morbid ..
  96. Neurogenic inflammation and psoriasiform dermatitis
    NICOLE LEANNE WARD; Fiscal Year: 2013
    ..These results imply a role for the nervous system in maintaining and exacerbating the psoriasis phenotype;however the role and contribution of nerves to the ..
  97. Brain Oxygen Metabolism and Hemodynamic Impairment in Multiple Sclerosis
    Yulin Ge; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS) and one of the most common causes of nontraumatic disability among young and middle-aged people...
  98. CRCNS: Theory and experiment of neural circuit mapping by DNA sequencing
    Anthony M Zador; Fiscal Year: 2013
    ..It is hard, if not impossible, to identify a medical condition involving the nervous system that would not affect neuronal connections.
  99. Molecular and Cellular Determinants of the Exercise Pressor Reflex in CHF
    Irving H Zucker; Fiscal Year: 2013
    ..Even during moderate exercise, extreme activation of the sympathetic nervous system is often seen causing an exaggerated pressor response and hyperventilation, which potentially increases ..
  100. RAX, PKR and ethanol neurotoxicity
    Gang Chen; Fiscal Year: 2013
    ..Central nervous system (CNS) damage is a major feature observed in FASD patients...
  101. MRP4 extrudes cAMP for localized regulation of calcium channel activity
    OLIVIA RUTH BUONARATI; Fiscal Year: 2013
    ..2-associated disorders in the central nervous system, including stroke, depression, anxiety, senility and Alzheimer's disease.