tendons

Summary

Summary: Fibrous bands or cords of CONNECTIVE TISSUE at the ends of MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.

Top Publications

  1. pmc Characterization of differential properties of rabbit tendon stem cells and tenocytes
    Jianying Zhang
    MechanoBiology Laboratory, Departments of Orthopaedic Surgery, Bioengineering, and Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15213, USA
    BMC Musculoskelet Disord 11:10. 2010
  2. pmc Interpreting second-harmonic generation images of collagen I fibrils
    Rebecca M Williams
    Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Biophys J 88:1377-86. 2005
  3. ncbi Mechanobiology of tendon
    James H C Wang
    MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, 210 Lothrop St, BST, E1647, Pittsburgh, PA 15213, USA
    J Biomech 39:1563-82. 2006
  4. ncbi Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche
    Yanming Bi
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, US National Institutes of Health, 30 Convent Dr 30 225 MSC 4320, Bethesda, Maryland 20892, USA
    Nat Med 13:1219-27. 2007
  5. pmc The role of engineered tendon matrix in the stemness of tendon stem cells in vitro and the promotion of tendon-like tissue formation in vivo
    Jianying Zhang
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Biomaterials 32:6972-81. 2011
  6. ncbi Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy
    A E Deconinck
    Department of Biochemistry, University of Oxford, United Kingdom
    Cell 90:717-27. 1997
  7. ncbi Absence of integrin alpha 7 causes a novel form of muscular dystrophy
    U Mayer
    Max Planck Institute for Biochemistry, Martinsried, Germany
    Nat Genet 17:318-23. 1997
  8. doi Tendinopathy--from basic science to treatment
    Graham Riley
    Soft Tissue Research Group, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Nat Clin Pract Rheumatol 4:82-9. 2008
  9. pmc Histology shows that elongated neck ribs in sauropod dinosaurs are ossified tendons
    Nicole Klein
    Steinmann Institute, Division of Palaeontology, University of Bonn, Bonn 53115, Germany
    Biol Lett 8:1032-5. 2012
  10. doi Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons
    Lauren V Schnabel
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, C3 187 Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 27:1392-8. 2009

Detail Information

Publications360 found, 100 shown here

  1. pmc Characterization of differential properties of rabbit tendon stem cells and tenocytes
    Jianying Zhang
    MechanoBiology Laboratory, Departments of Orthopaedic Surgery, Bioengineering, and Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15213, USA
    BMC Musculoskelet Disord 11:10. 2010
    b>Tendons are traditionally thought to consist of tenocytes only, the resident cells of tendons; however, a recent study has demonstrated that human and mouse tendons also contain stem cells, referred to as tendon stem/progenitor cells (..
  2. pmc Interpreting second-harmonic generation images of collagen I fibrils
    Rebecca M Williams
    Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Biophys J 88:1377-86. 2005
    ..Fibrillogenesis can be resolved in immature tissue by directly imaging backward-propagating SHG. Such findings are crucial to the design and development of forthcoming diagnostic and research tools...
  3. ncbi Mechanobiology of tendon
    James H C Wang
    MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, 210 Lothrop St, BST, E1647, Pittsburgh, PA 15213, USA
    J Biomech 39:1563-82. 2006
    b>Tendons are able to respond to mechanical forces by altering their structure, composition, and mechanical properties--a process called tissue mechanical adaptation...
  4. ncbi Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche
    Yanming Bi
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, US National Institutes of Health, 30 Convent Dr 30 225 MSC 4320, Bethesda, Maryland 20892, USA
    Nat Med 13:1219-27. 2007
    The repair of injured tendons remains a great challenge, largely owing to a lack of in-depth characterization of tendon cells and their precursors...
  5. pmc The role of engineered tendon matrix in the stemness of tendon stem cells in vitro and the promotion of tendon-like tissue formation in vivo
    Jianying Zhang
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Biomaterials 32:6972-81. 2011
    When injured, tendons tend to heal but with poor structure and compromised function. Tissue engineering is a promising approach to enhancing the quality of healing tendons...
  6. ncbi Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy
    A E Deconinck
    Department of Biochemistry, University of Oxford, United Kingdom
    Cell 90:717-27. 1997
    ..Detailed study of these mice should provide novel insights into the pathogenesis of DMD and provide an improved model for rapid evaluation of gene therapy strategies...
  7. ncbi Absence of integrin alpha 7 causes a novel form of muscular dystrophy
    U Mayer
    Max Planck Institute for Biochemistry, Martinsried, Germany
    Nat Genet 17:318-23. 1997
    ....
  8. doi Tendinopathy--from basic science to treatment
    Graham Riley
    Soft Tissue Research Group, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Nat Clin Pract Rheumatol 4:82-9. 2008
    Chronic tendon pathology (tendinopathy), although common, is difficult to treat. Tendons possess a highly organized fibrillar matrix, consisting of type I collagen and various 'minor' collagens, proteoglycans and glycoproteins...
  9. pmc Histology shows that elongated neck ribs in sauropod dinosaurs are ossified tendons
    Nicole Klein
    Steinmann Institute, Division of Palaeontology, University of Bonn, Bonn 53115, Germany
    Biol Lett 8:1032-5. 2012
    ..consists of longitudinally oriented mineralized collagen fibres, essentially the same tissue as found in ossified tendons. The absence of regular periosteal bone and the dominance of longitudinal fibres contradict the ventral bracing ..
  10. doi Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons
    Lauren V Schnabel
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, C3 187 Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 27:1392-8. 2009
    ..Collagenase-induced bilateral tendinitis lesions were created in equine flexor digitorum superficialis tendons (SDFT). Tendons were treated with 10 x 10(6) MSCs or 10 x 10(6) AdIGF-MSCs...
  11. doi Prevention of adhesions in surgery of the flexor tendons of the hand: what is the evidence?
    Anil Khanna
    Centre for Sports and Exercise Medicine, Barts and the London School of Medicine and Dentistry, Mile End Hospital, London E1 4DG, UK
    Br Med Bull 90:85-109. 2009
    ..This in turn has led to a massive expansion in search of modified surgical therapies and various adjuvant therapies, which could prevent adhesion formation without compromising digital function...
  12. ncbi Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes
    Chisa Shukunami
    Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Dev Biol 298:234-47. 2006
    ..II transmembrane glycoprotein containing a C-terminal anti-angiogenic domain and is predominantly expressed in tendons and ligaments...
  13. ncbi Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon
    L Svensson
    Department of Cell and Molecular Biology, University of Lund, P O Box 94, S 221 00 Lund, Sweden
    J Biol Chem 274:9636-47. 1999
    ..These results demonstrate a role for fibromodulin in collagen fibrillogenesis and suggest that the orchestrated action of several leucine-rich repeat glycoproteins/proteoglycans influence the architecture of collagen matrices...
  14. doi Stepwise differentiation of human embryonic stem cells promotes tendon regeneration by secreting fetal tendon matrix and differentiation factors
    Xiao Chen
    Center for Stem Cells and Tissue Engineering, Institute of Cell Biology, School of Medicine, Zhejiang University, Hangzhou, China
    Stem Cells 27:1276-87. 2009
    ..Moreover, no teratoma was found in any samples. These findings demonstrate a safe and practical strategy of applying ESCs for tendon regeneration and may assist in future strategies to treat tendon diseases...
  15. ncbi Cyclic mechanical stretching of human tendon fibroblasts increases the production of prostaglandin E2 and levels of cyclooxygenase expression: a novel in vitro model study
    James H C Wang
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Connect Tissue Res 44:128-33. 2003
    Prostaglandin E(2) (PGE(2)) is a known inflammatory mediator of tendinitis, for which mechanical loading on tendons is believed to be one of the most prominent causation factors...
  16. ncbi Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles
    Hazel R C Screen
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem Biophys Res Commun 336:424-9. 2005
    ..These data provide evidence of altered anabolic activity within tendon in response to mechanical stimuli, and suggest the importance of cyclic tensile loading for the maintenance of the collagen hierarchy within tendon...
  17. ncbi Evaluation of active knee flexion and hamstring strength after anterior cruciate ligament reconstruction using hamstring tendons
    Norimasa Nakamura
    Department of Orthopaedic Sports Medicine, Osaka Rosai Hospital, Sakai, Osaka, Japan
    Arthroscopy 18:598-602. 2002
    ..The purpose of this study was to evaluate active knee flexion range of motion and hamstring strength following hamstring anterior cruciate ligament (ACL) reconstruction...
  18. ncbi Horses damp the spring in their step
    A M Wilson
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hatfield, Herts AL9 7TA, UK
    Nature 414:895-9. 2001
    ..the digital flexor muscles have extremely short fibres and significant passive properties, whereas the tendons are very long and span several joints...
  19. ncbi Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments
    R Schweitzer
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Development 128:3855-66. 2001
    Little is known about the genesis and patterning of tendons and other connective tissues, mostly owing to the absence of early markers...
  20. pmc Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction
    Einat Blitz
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Cell 17:861-73. 2009
    ..system, bone ridges provide a stable anchoring point and stress dissipation for the attachment of muscles via tendons to the skeleton...
  21. pmc Expression of collagen and related growth factors in rat tendon and skeletal muscle in response to specific contraction types
    K M Heinemeier
    Institute of Sports Medicine, Bispebjerg Hospital Building 8, 1st Floor, 23 Bispebjerg Bakke, DK 2400 Copenhagen NV, Denmark
    J Physiol 582:1303-16. 2007
    ....
  22. pmc Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury
    Jane M Fedorczyk
    Department of Physical Therapy and Rehabilitation Sciences, Drexel University, 245 North 15th Street, MS502, Philadelphia, Pennsylvania 19102, USA
    J Orthop Res 28:298-307. 2010
    ..We used our rat model of repetitive strain injury to study changes induced in forelimb flexor digitorum tendons. Rats were trained to perform a high repetition high force (HRHF) handle-pulling task (12 reaches/min at 60 +/- 5%..
  23. ncbi Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons
    Nicholas D Murchison
    Shriners Hospital for Children, Research Division, Portland, OR 97239, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 134:2697-708. 2007
    ..Interestingly, although the differentiation of all force-transmitting and intermuscular tendons was disrupted, other categories of tendons, the function of which is mainly to anchor muscles to the skeleton, ..
  24. doi Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes
    Jianying Zhang
    Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213, USA
    Am J Sports Med 38:2477-86. 2010
    ..However, the cellular mechanisms underlying PRP treatment of injured tendons remain unclear...
  25. pmc Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair
    Stephanie Georgina Dakin
    Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, Hatfield, United Kingdom
    PLoS ONE 7:e32333. 2012
    ..sub-acute (3-6 weeks post injury) and chronically injured (>3 months post injury) superficial digital flexor tendons. To determine if inflammation was present in injured tendons, Mφ sub-populations were quantified based on ..
  26. pmc Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function
    P X Xu
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:11974-9. 1997
    Vertebrate limb tendons are derived from connective cells of the lateral plate mesoderm...
  27. pmc Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease
    Stephanie Georgina Dakin
    Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, Hatfield, United Kingdom
    PLoS ONE 7:e48978. 2012
    ..A(4) (LXA(4)) and its receptor FPR2/ALX were analysed in extracts of normal, sub-acute and chronic injured tendons. To assess whether potential changes were associated with altered PGE(2) metabolism, microsomal prostaglandin E ..
  28. doi Ageing of human muscles and tendons
    Marco V Narici
    Institute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Cheshire, UK
    Disabil Rehabil 30:1548-54. 2008
    ..It seems that natural strategies may be in place to ensure that the relative operating range of muscle remains unaltered by changes in physical activity, and perhaps age...
  29. pmc Effect of in vitro passaging on the stem cell-related properties of tendon-derived stem cells-implications in tissue engineering
    Qi Tan
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Stem Cells Dev 21:790-800. 2012
    ..Researchers and clinicians should consider the changes of stem cell-related properties of TDSCs when multiplying them in vitro for tissue engineering...
  30. doi Method of preparing a decellularized porcine tendon using tributyl phosphate
    C R Deeken
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Biomed Mater Res B Appl Biomater 96:199-206. 2011
    ....
  31. doi Maturational alterations in gap junction expression and associated collagen synthesis in response to tendon function
    N J Young
    Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, United Kingdom
    Matrix Biol 28:311-23. 2009
    Energy-storing tendons including the equine superficial digital flexor tendon (SDFT) contribute to energetic efficiency of locomotion at high-speed gaits, but consequently operate close to their physiological strain limits...
  32. pmc Force and scleraxis synergistically promote the commitment of human ES cells derived MSCs to tenocytes
    Xiao Chen
    Center for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China
    Sci Rep 2:977. 2012
    As tendon stem/progenitor cells were reported to be rare in tendon tissues, tendons as vulnerable targets of sports injury possess poor self-repair capability. Human ESCs (hESCs) represent a promising approach to tendon regeneration...
  33. pmc Specimen dimensions influence the measurement of material properties in tendon fascicles
    Kirsten Legerlotz
    School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E14NS, UK
    J Biomech 43:2274-80. 2010
    ..area (CSA) appear to influence failure stress, strain and modulus in fascicles from two functionally different tendons. Fascicles were dissected from five rat tails and five bovine foot extensors, their diameters determined by a ..
  34. doi An investigation of the relationship between race performance and superficial digital flexor tendonitis in the Thoroughbred racehorse
    B O'Meara
    Faculty of Veterinary Medicine, University of Glasgow, Glasgow G61 IQH, Scotland, UK
    Equine Vet J 42:322-6. 2010
    ..There is limited information regarding the number of races and the period for evaluation of outcome which is critical for assessment of SDF tendonitis treatments...
  35. doi Diabetes mellitus impairs tendon-bone healing after rotator cuff repair
    Asheesh Bedi
    Laboratory for Soft Tissue Research, Hospital for Special Surgery, New York, NY 10021, USA
    J Shoulder Elbow Surg 19:978-88. 2010
    ..Studies have demonstrated a significant decrease in skeletal mass, bone mineral density, and impaired fracture healing in the diabetic population. However, the effect of sustained hyperglycemia on tendon-to-bone healing is unknown...
  36. ncbi Characterization and differentiation of equine tendon-derived progenitor cells
    A B Lovati
    Universita degli Studi di Milano, Department of Veterinary Clinical Science, Lodi, Italy
    J Biol Regul Homeost Agents 25:S75-84. 2011
    ..Population of adult stem cells were recently identified in human and lab animal tendons, but no detailed investigations have been made in the equine species...
  37. doi Subrupture tendon fatigue damage
    David T Fung
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Orthop Res 27:264-73. 2009
    ..To investigate the tendon fatigue process, rat flexor digitorum longus tendons were cyclically loaded (1-16 N) until reaching one of three levels of fatigue damage, defined as peak clamp-to-..
  38. doi MMP-1, IL-1beta, and COX-2 mRNA expression is modulated by static load in rabbit flexor tendons
    Krishna R Asundi
    Ergonomics Program, Department of Bioengineering, University of California, Berkeley, 1301 South 46th Street, Building 163, Richmond, CA 94804, USA
    Ann Biomed Eng 36:237-43. 2008
    ..Forty flexor tendons from 10 New Zealand White rabbits were harvested and secured in a tissue loading system...
  39. ncbi Histopathology of the A1 pulley in adult trigger fingers
    M C Sbernardori
    Department of Orthopaedics, University School of Medicine, Sassari, Italy
    J Hand Surg Eur Vol 32:556-9. 2007
    ..The outermost layer was formed of loose connective tissue. In conclusion, there was an additional layer in the A1 pulley in pathological cases which was not present in normal pulleys...
  40. pmc Loss of homeostatic strain alters mechanostat "set point" of tendon cells in vitro
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, G 387, Michigan State University, East Lansing, MI, USA
    Clin Orthop Relat Res 466:1583-91. 2008
    ..tension following stress deprivation decreases the mechanoresponsiveness of tendon cells, we cultured rat tail tendons under stress-deprived conditions for 48 hours and then cyclically loaded them for 24 hours at 1%, 3%, or 6% ..
  41. doi New method for Raman investigation of the orientation of collagen fibrils and crystallites in the Haversian system of bone
    Guillaume Falgayrac
    Univ Lille Nord de France, F 59000 Lille, France
    Appl Spectrosc 64:775-80. 2010
    ..This work highlights the interest of Raman spectroscopy for the multiscale investigation of bone structure...
  42. doi Flexor tendon tissue engineering: acellularization of human flexor tendons with preservation of biomechanical properties and biocompatibility
    Brian C Pridgen
    Section of Plastic Surgery, VA Palo Alto Health Care System and the Division of Plastic Surgery, Stanford University Medical Center, Stanford, California 94305, USA
    Tissue Eng Part C Methods 17:819-28. 2011
    Acellular human tendons are a candidate scaffold for tissue engineering flexor tendons of the hand. This study compared acellularization methods and their compatibility with allogeneic human cells.
  43. ncbi Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene
    Brian A Pryce
    Shriners Hospital for Children, Research Division, Portland, Oregon 97239, USA
    Dev Dyn 236:1677-82. 2007
    ..Scx encodes a transcription factor expressed in all developing tendons and ligaments as well as in their progenitors...
  44. doi The effect of graft tissue on anterior cruciate ligament outcomes: a multicenter, prospective, randomized controlled trial comparing autograft hamstrings with fresh-frozen anterior tibialis allograft
    Keith W Lawhorn
    Commonwealth Orthopaedics and Rehabilitation, 3620 Joseph Siewick Drive, Fairfax, VA 22033, U S A
    Arthroscopy 28:1079-86. 2012
    ..To compare the results and outcome of anterior cruciate ligament (ACL) reconstruction using autogenous hamstring tendon versus fresh-frozen allograft anterior tibialis tendon...
  45. pmc Polarization-resolved second-harmonic generation in tendon upon mechanical stretching
    Ivan Gusachenko
    Laboratory for Optics and Biosciences, Ecole Polytechnique, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale U696, Palaiseau, France
    Biophys J 102:2220-9. 2012
    ..Our data show an excellent agreement with recently published theoretical calculations of the collagen triple helix hyperpolarizability...
  46. ncbi Neoangiogenesis is reduced in chronic tendinopathies of type 2 diabetic patients
    M Abate
    G d Annunzio University Foundation, University G D Annunzio Chieti Pescara, Chieti, Italy
    Int J Immunopathol Pharmacol 25:757-61. 2012
    ..In subjects with diabetes, tendinopathic features are significantly higher than healthy controls, while the prevalence of neovascularisation inside tendons is less represented.
  47. doi Systematic review of single-bundle anterior cruciate ligament reconstruction outcomes: a baseline assessment for consideration of double-bundle techniques
    Paul B Lewis
    Division of Sports Medicine, Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Sports Med 36:2028-36. 2008
    ..Challenging this comparison, however, has been the lack of an established consensus on the success of single-bundle reconstruction...
  48. doi Changes in gene expression of individual matrix metalloproteinases differ in response to mechanical unloading of tendon fascicles in explant culture
    Diane R Leigh
    Department of Biomedical Engineering, Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Orthop Res 26:1306-12. 2008
    ..This data will help to further elucidate the mechanism for the loss of mechanical properties associated with mechanical unloading in tendon...
  49. doi Multilayer tendon slices seeded with bone marrow stromal cells: a novel composite for tendon engineering
    Hiromichi Omae
    Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, 200 First Street S W, Rochester, Minnesota 55905, USA
    J Orthop Res 27:937-42. 2009
    ..BMSC and infraspinatus tendons were harvested from 20 dogs. The tendons were sectioned in longitudinal slices with a thickness of 50 microm...
  50. doi Anatomy, function, injuries, and treatment of the long head of the biceps brachii tendon
    Florian Elser
    Steadman Philippon Research Institute, Vail, Colorado 81657, USA
    Arthroscopy 27:581-92. 2011
    ..The purpose of this article is to offer an up-to-date review of the anatomy and biomechanical properties of the LHB and to provide an evidence-based approach to current treatment strategies for LHB disorders...
  51. ncbi The interface of mechanical loading and biological variables as they pertain to the development of tendinosis
    G M Thornton
    McCaig Institute for Bone and Joint Health, Department of Surgery, University of Calgary, Calgary, Alberta, Canada
    J Musculoskelet Neuronal Interact 11:94-105. 2011
    Different tendons are designed to withstand different mechanical loads in their individual environments. Variable physiologic loading ranges and correspondingly different injury thresholds lead to tendon heterogeneity...
  52. ncbi A comparison of tenocytes and mesenchymal stem cells for use in flexor tendon tissue engineering
    Gil S Kryger
    Division of Plastic Surgery, Stanford University Medical Center, Palo Alto, CA 94304, USA
    J Hand Surg Am 32:597-605. 2007
    Tissue-engineered tendon grafts will meet an important clinical need. To engineer tendons, we used acellularized allogeneic tendon as scaffold material...
  53. doi Effect of in vitro stress-deprivation and cyclic loading on the length of tendon cell cilia in situ
    Keri Gardner
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    J Orthop Res 29:582-7. 2011
    ..effect of loading conditions on the length of primary cilia in tendon cells in situ, freshly harvested rat tail tendons were stress-deprived (SD) for up to 72 h, cyclically loaded at 3% strain at 0...
  54. doi Mechanical loading increased BMP-2 expression which promoted osteogenic differentiation of tendon-derived stem cells
    Yun Feng Rui
    Faculty of Medicine, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Orthop Res 29:390-6. 2011
    ..Activation of BMP-2 expression in TDSCs during tendon overuse might provide a possible explanation of ectopic calcification in calcifying tendinopathy...
  55. pmc Gap junction protein expression and cellularity: comparison of immature and adult equine digital tendons
    Rachael L Stanley
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hatfield, Hertfordshire, UK
    J Anat 211:325-34. 2007
    ..Cx32 protein per tenocyte was significantly higher in the fetal group compared with all other age groups in both tendons. The density of tenocytes was found to be highest in immature tissue...
  56. ncbi Knee stability and graft function following anterior cruciate ligament reconstruction: Comparison between 11 o'clock and 10 o'clock femoral tunnel placement. 2002 Richard O'Connor Award paper
    John C Loh
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Arthroscopy 19:297-304. 2003
    ..Type of Study: Biomechanical experiment using human cadaveric specimens...
  57. doi Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions)
    Sandra Shahab-Osterloh
    Inflammation and Regeneration, Helmholtz Centre for Infection Research HZI, Braunschweig, Germany
    Stem Cells 28:1590-601. 2010
    ..These findings may contribute to the establishment of stem cell-dependent regenerative therapies involving tendon/ligaments and to the improvement of the insertion of tendon grafts at bony attachment sites, eventually...
  58. doi Three-dimensional high-density co-culture with primary tenocytes induces tenogenic differentiation in mesenchymal stem cells
    Philipp R A Schneider
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilian University of Munich, Pettenkoferstrasse 11, 80336 Munich, Germany
    J Orthop Res 29:1351-60. 2011
    ..This approach may prove to be of practical benefit in future tissue engineering and tendon regenerative medicine research...
  59. pmc Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates
    Ronen Schweitzer
    Shriners Hospital for Children, Research Division, Portland, OR 97239, USA
    Development 137:2807-17. 2010
    ..system represents an intricate process of tissue assembly involving heterotypic inductive interactions between tendons, muscles and cartilage...
  60. doi Treatment of anterior cruciate ligament injuries with special reference to graft type and surgical technique: an assessment of randomized controlled trials
    Kristian Samuelsson
    Department of Orthopaedics, Sahlgrenska University Hospital, SE 431 80, Molndal, Sweden
    Arthroscopy 25:1139-74. 2009
    ..The secondary aims were to identify the relative strengths and weaknesses of the selected studies, to resolve contradictions in the literature, and to evaluate the need for further studies...
  61. doi Anatomic double-bundle anterior cruciate ligament reconstruction using hamstring tendons with minimally required initial tension
    Tatsuo Mae
    Department of Sports Medicine, Osaka Kousei Nenkin Hospital, Osaka, Japan
    Arthroscopy 26:1289-95. 2010
    ..3 N; range, 2.2 to 14 N)...
  62. ncbi Basic biology of tendon injury and healing
    P Sharma
    Salisbury District Hospital, Wessex Deanery, UK
    Surgeon 3:309-16. 2005
    ..At present the aetiology of tendon disorders remains unclear, with several factors having been implicated. An improved understanding of tendon injury and healing is essential to enable focused treatment strategies to be devised...
  63. ncbi Broken bioabsorbable femoral cross-pin after anterior cruciate ligament reconstruction with hamstring tendon graft: a case report
    Ilkyu Han
    Department of Orthopedic Surgery, Seoul National University College of Medicine, Korea
    Am J Sports Med 33:1742-5. 2005
  64. doi Stem cells for tendon tissue engineering and regeneration
    Zi Yin
    Zhejiang University, School of Medicine, Center for Stem Cell and Tissue Engineering, Mailbox 39, 388 Yu Hang Tang Road, Hangzhou 310058, China
    Expert Opin Biol Ther 10:689-700. 2010
    ..With advances in stem cell biology, tissue engineering is becoming increasingly powerful for tissue regeneration. Stem cells with capacity of multipotency and self-renewal are an ideal cell source for tissue engineering...
  65. ncbi Abnormal tenocyte morphology is more prevalent than collagen disruption in asymptomatic athletes' patellar tendons
    J L Cook
    Musculoskeletal Research Centre, La Trobe University, Victoria 3086, Australia
    J Orthop Res 22:334-8. 2004
    ..tendon graft were screened for previous tendon symptoms, training and playing history and had their patellar tendons examined with ultrasound prior to surgery...
  66. ncbi Biology of tendon injury: healing, modeling and remodeling
    P Sharma
    Salisbury District Hospital, Wessex Deanery, United Kingdom
    J Musculoskelet Neuronal Interact 6:181-90. 2006
    ..The term tendinopathy is a generic descriptor of the clinical conditions in and around tendons arising from overuse...
  67. ncbi Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons
    Lauren V Schnabel
    Department of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 25:230-40. 2007
    ..IGF-I, TGF-beta1, and PDGF-BB were quantified in all blood products using ELISA. Tendons were cultured in explant fashion with blood, plasma, PRP, PPP, or BMA at concentrations of 100%, 50%, or 10% in ..
  68. ncbi Reconstruction of the coracoclavicular ligaments with tendon grafts: a comparative biomechanical study
    Steven J Lee
    Nicholas Institute of Sports Medicine and Athletic Trauma, Department of Orthopaedic Surgery, Lenox Hill Hospital The Cooper Union for the Advancement of Science and Art, New York, New York 10021, USA
    Am J Sports Med 31:648-55. 2003
    ..Numerous surgical techniques have been described to address injuries to the coracoclavicular ligaments...
  69. pmc Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis
    Paolo Alberton
    Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig Maximilians University LMU, Munich, Germany
    Stem Cells Dev 21:846-58. 2012
    b>Tendons and ligaments (T/L) are dense connective tissues of mesodermal origin...
  70. ncbi Ibuprofen inhibition of tendon cell proliferation and upregulation of the cyclin kinase inhibitor p21CIP1
    Wen Chung Tsai
    Department of Physical Medicine and Rehabilitation, Graduate Institute of Clinical Medical Sciences, Chang Gung Memorial Hospital, Chang Gung University, Building J, 12F, 5 Fu Shing Street, Kweishan, Taoyuan 333, Taiwan
    J Orthop Res 22:586-91. 2004
    ..In conclusion, ibuprofen inhibits tendon cell proliferation in a process that is probably mediated by the upregulation of p21(CIP1) and reduced phosphorylation of Rb protein...
  71. pmc Type XIV Collagen Regulates Fibrillogenesis: PREMATURE COLLAGEN FIBRIL GROWTH AND TISSUE DYSFUNCTION IN NULL MICE
    Heather L Ansorge
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:8427-38. 2009
    ..mice, the developmental expression patterns were analyzed in wild-type flexor digitorum longus (FDL) tendons. Analyses of mRNA and protein expression indicated tissue-specific temporal expression that was associated with ..
  72. doi Tendon-selective genes identified from rat and human musculoskeletal tissues
    Scott A Jelinsky
    Tissue Repair, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    J Orthop Res 28:289-97. 2010
    ..In conclusion, this study has defined a set of tendon-selective genes present in both adult rat and human tendons. Identification of tendon-selective genes provides potential molecular tools to facilitate a better understanding ..
  73. ncbi The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles
    Hazel R C Screen
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, London, E1 4NS, United Kingdom
    Ann Biomed Eng 33:1090-9. 2005
    ..This highlights the importance of maintaining fascicles within their natural environment to prevent structural or mechanical changes prior to subsequent analysis...
  74. ncbi Influence of medial hamstring tendon harvest on knee flexor strength after anterior cruciate ligament reconstruction. A detailed evaluation with comparison of single- and double-tendon harvest
    Toshiyuki Tashiro
    Department of Orthopaedic Surgery, Tokyo Teishin Hospital, Tokyo, Japan
    Am J Sports Med 31:522-9. 2003
    ..The advantages of hamstring tendon autografts for anterior cruciate ligament reconstruction are well known; however, concerns have arisen regarding the influence of hamstring tendon harvest on postoperative weakness in knee flexion...
  75. ncbi Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types
    K M Heinemeier
    Institute of Sports Medicine, Bispebjerg Hospital Bldg 8, 1st Floor, 23 Bispebjerg Bakke, DK 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 102:573-81. 2007
    ....
  76. doi Scaffolds for tendon and ligament repair: review of the efficacy of commercial products
    Jimin Chen
    Centre for Orthopaedics Research, School of Surgery University of Western Australia, Room 2 33, 2nd Floor, M Block, QEII Medical Centre, Nedlands, Perth, WA 6009, Australia
    Expert Rev Med Devices 6:61-73. 2009
    ..and the others were reviews, editorials, commentaries, animal studies or related to applications other than tendons and ligaments...
  77. ncbi Mechanical loading regulates the expression of tenascin-C in the myotendinous junction and tendon but does not induce de novo synthesis in the skeletal muscle
    Tero A H Järvinen
    Institute of Medical Technology and Medical School, University of Tampere, Tampere, Finland
    J Cell Sci 116:857-66. 2003
    ..Our results suggest that tenascin-C provides elasticity in mesenchymal tissues subjected to heavy tensile loading...
  78. ncbi Repeated exposure of tendon to prostaglandin-E2 leads to localized tendon degeneration
    Mustafa H Khan
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, 210 Lothrop Street, Pittsburgh, PA 15213, USA
    Clin J Sport Med 15:27-33. 2005
    ..To determine whether repeated exposure of rabbit patellar tendon to prostaglandin-E(2) leads to degenerative changes in the tendon...
  79. ncbi Evaluation of hamstring strength and tendon regrowth after harvesting for anterior cruciate ligament reconstruction
    Kou Tadokoro
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Am J Sports Med 32:1644-50. 2004
    ..thought that tissue regeneration and good functional recovery can be expected after anterior cruciate ligament reconstruction using the hamstring tendons. However, persistent strength deficit in deep knee flexion has also been reported.
  80. ncbi A prospective randomized study of 4-strand semitendinosus tendon anterior cruciate ligament reconstruction comparing single-bundle and double-bundle techniques
    Takeshi Muneta
    Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthroscopy 23:618-28. 2007
    ..A randomized clinical study was conducted to compare the outcome between double-bundle (DB) and single-bundle (SB) anterior cruciate ligament (ACL) reconstructions with 4-strand semitendinosus tendon (ST)...
  81. ncbi The fixation strength of six hamstring tendon graft fixation devices in anterior cruciate ligament reconstruction. Part I: femoral site
    Petteri Kousa
    Department of Surgery, University of Tampere and Tampere University Hospital, Tampere, Finland
    Am J Sports Med 31:174-81. 2003
    ..Strength of graft fixation is the weakest link in anterior cruciate ligament reconstruction...
  82. ncbi Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts
    Véronique Lejard
    INSERM U652 and Paris Descartes University, 75006 Paris, France
    J Biol Chem 282:17665-75. 2007
    ..This led us to show that the NFATc4 gene is expressed in tendons of developing mouse limbs and in TT-D6 cells, a cell line that has characteristics of tendon fibroblasts...
  83. ncbi Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property
    R Salingcarnboriboon
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Exp Cell Res 287:289-300. 2003
    ..These observations indicated that the established tendon cell line possesses mesenchymal stem cell-like properties, suggesting the existence of mesenchymal stem cell in tendon tissue...
  84. ncbi Functional efficacy of tendon repair processes
    David L Butler
    Department of Biomedical Engineering, Noyes Giannestras Biomechanics Laboratory, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Annu Rev Biomed Eng 6:303-29. 2004
    ..The paper concludes with future directions...
  85. doi From mechanical loading to collagen synthesis, structural changes and function in human tendon
    M Kjaer
    Department of Orthopaedics, Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 19:500-10. 2009
    ..that habitual loading is associated with a robust change in the size and mechanical properties of human tendons. An intimate interplay between mechanical signalling and biochemical changes in the matrix is needed in tendon, ..
  86. ncbi Anatomic reconstruction of the anteromedial and posterolateral bundles of the anterior cruciate ligament using hamstring tendon grafts
    Kazunori Yasuda
    Department of Sports Medicine and Joint Reconstruction Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Arthroscopy 20:1015-25. 2004
    ..To develop and evaluate an anatomic reconstruction procedure of the posterolateral and anteromedial bundles of the anterior cruciate ligament (ACL)...
  87. ncbi Repair of tendon defect with dermal fibroblast engineered tendon in a porcine model
    Wei Liu
    Department of Plastic and Reconstructive Surgery, Shanghai Ninth People s Hospital, Shanghai Tissue Engineering Center, Shanghai Second Medical University, Shanghai, PR China
    Tissue Eng 12:775-88. 2006
    ..In vivo results showed that fibroblast and tenocyte engineered tendons were similar to each other in their gross view, histology, and tensile strength...
  88. ncbi Bridging tendon defects using autologous tenocyte engineered tendon in a hen model
    Yilin Cao
    Department of Plastic and Reconstructive Surgery, Shanghai Ninth People s Hospital, Tissue Engineering Center, Shanghai Second Medical University, Shanghai, ROC
    Plast Reconstr Surg 110:1280-9. 2002
    ..In a total of 40 Leghorn hens, flexor tendons were harvested from the left feet and were digested with 0.25% type II collagenase...
  89. ncbi Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats
    Alexander Scott
    University of British Columbia, Vancouver, British Columbia, Canada
    Arthritis Rheum 56:871-81. 2007
    ..To investigate tenocyte regulatory events during the development of overuse supraspinatus tendinosis in rats...
  90. pmc Extracellular matrix adaptation of tendon and skeletal muscle to exercise
    Michael Kjaer
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    J Anat 208:445-50. 2006
    ..enables linking to other tissues, and plays a key role in force transmission and tissue structure maintenance in tendons, ligaments, bone and muscle...
  91. ncbi Assessment of peripheral enthesitis in the spondylarthropathies by ultrasonography combined with power Doppler: a cross-sectional study
    Maria Antonietta d'Agostino
    Cochin Hospital, INSERM, CNRS, Universite Rene Descartes, AP HP, Paris, France
    Arthritis Rheum 48:523-33. 2003
    ..To assess the prevalence and severity of peripheral enthesitis among the different subtypes of spondylarthropathy (SpA) by using ultrasonography (US) in B mode with power Doppler...
  92. ncbi Knee stability and graft function after anterior cruciate ligament reconstruction: a comparison of a lateral and an anatomical femoral tunnel placement
    Yuji Yamamoto
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Sports Med 32:1825-32. 2004
    ..Locations of femoral tunnels for anterior cruciate ligament replacement grafts remain a subject of debate...
  93. ncbi The role of decorin in collagen fibrillogenesis and skin homeostasis
    Charles C Reed
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Glycoconj J 19:249-55. 2002
    ..Overall, decorin is shown to be a vital player in maintaining skin and tendon integrity at the molecular level, among other functions...
  94. doi Microstructural stress relaxation mechanics in functionally different tendons
    H R C Screen
    School of Engineering and Materials Science, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Med Eng Phys 35:96-102. 2013
    b>Tendons experience widely varying loading conditions in vivo...
  95. doi Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options
    Roshan James
    Department of Orthopaedic Surgery, Orthopaedic Research Laboratories, University of Virginia Health System, Charlottesville, VA 22908 0159, USA
    J Hand Surg Am 33:102-12. 2008
    ....
  96. pmc Combined high-resolution magnetic resonance imaging and histological examination to explore the role of ligaments and tendons in the phenotypic expression of early hand osteoarthritis
    A L Tan
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 65:1267-72. 2006
    ....
  97. ncbi The landing-take-off asymmetry in human running
    G A Cavagna
    Istituto di Fisiologia Umana, Universita degli Studi di Milano, Via Mangiagalli, 32, 20133 Milan, Italy
    J Exp Biol 209:4051-60. 2006
    ..Above this speed, the two durations (<0.1 s) are similar, suggesting that the length change is almost totally due to stretch-recoil of the tendons with nearly isometrically contracting fibres.
  98. pmc Aspartic acid racemization and collagen degradation markers reveal an accumulation of damage in tendon collagen that is enhanced with aging
    Chavaunne T Thorpe
    Division of Surgery and Interventional Science, University College London, Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, London, UK
    J Biol Chem 285:15674-81. 2010
    ..is known about the rate at which protein turnover occurs in living tendon and whether the rate differs between tendons with different physiological roles...
  99. doi Allogenous tendon stem/progenitor cells in silk scaffold for functional shoulder repair
    Weiliang Shen
    Center for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China
    Cell Transplant 21:943-58. 2012
    ..Hence, allogenous TSPC-seeded knitted silk-collagen sponge scaffolds can be a clinically useful application for tendon tissue engineering...
  100. doi Proliferation and differentiation of human tenocytes in response to platelet rich plasma: an in vitro and in vivo study
    Xiao Wang
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK
    J Orthop Res 30:982-90. 2012
    ..Overall, our feasibility study has indicated that PRCR can induce human tenocyte proliferation and collagen synthesis which could be implemented for future tendon regeneration in reconstructive surgeries...
  101. pmc Structural and mechanical effects of in vivo fatigue damage induction on murine tendon
    Jedd B Sereysky
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Orthop Res 30:965-72. 2012
    ..Patellar tendons of C57BL/6J mice were fatigue loaded at 2 Hz to three endpoints (4 N peak force per cycle for 1 h, 6 N for 1 h, ..

Research Grants72

  1. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..They are viable and fertile, but have marked exercise intolerance, reduced collagen fibril diameter in tendons, and overly compliant great vessels of the heart...
  2. Novel Collagen II Alternative Transcripts and Mouse Skeletal Development
    Audrey McAlinden; Fiscal Year: 2010
    ..non-cartilage tissues such as the notochord, somitic mesoderm, fetal brain, spinal cord, developing eye, tendons and ligaments...
  3. Aligned Tendon or Ligament Derived Matrix Nanoscaffolds for Rotator Cuff Repair
    Dianne Little; Fiscal Year: 2013
    ..Research: The rotator cuff is a composite of joint capsule, tendons and ligaments that is critical for stability and function of the shoulder...
  4. Human tendon stem progenitor cell aging and regeneration
    Hui Bin Sun; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aging tendons become more susceptible to injury and less able to heal damage...
  5. Processing and Preservation of Human Umbilical Cord Stem Cells for Cell Therapeut
    Alfred Bahnson; Fiscal Year: 2010
    ..cells have potential to be used for un-related donors to treat diseases related to cartilage, bone, muscle or tendons/ligaments...
  6. Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
    Joseph E Losee; Fiscal Year: 2013
    ..e. the attachment of mTVP tendons to the ipsilateral hamulus before mTVP tendon transection...
  7. Role of endocytosis by the neural crest in cardio-craniofacial development
    ANNA LUISE KEYTE; Fiscal Year: 2013
    ..In the head the cranial NCCs contribute to cartilage, bone, fascia and tendons associated with craniofacial muscles...
  8. Hereditary Multiple Exostosis Syndrome: Pathogenesis and Treatment
    MAURIZIO contact PACIFICI; Fiscal Year: 2010
    ..The exostoses can thus cause growth retardation, compression of nerves and tendons, skeletal deformities and early onset osteoarthritis, and become malignant in about 5% of patients...
  9. 2012 Proteoglycans Gordon Research Conference
    Robert J Linhardt; Fiscal Year: 2012
    ..systems including the formation and pathology of many parts of the musculoskeletal system such as muscle, bone, tendons and teeth...
  10. Role of Muscle Connective Tissue in Muscle and Tendon Development
    Gabrielle Kardon; Fiscal Year: 2013
    ..limb, muscle derives from migratory precursors originating from the somites, while the muscle connective tissue, tendons, and skeletal elements derive from the mesoderm of the emerging lateral plate-derived limb bud...
  11. Dual-Energy Cone-Beam Tomographic Imaging and Analysis for Rheumatoid Arthritis
    Jeffrey H Siewerdsen; Fiscal Year: 2013
    ..isotropic, sub-millimeter spatial resolution and soft-tissue contrast including synovial tissues, cartilage, tendons, and ligaments through DE decomposition...
  12. Noninvasive Measurement Of Strain And Mechanical Properties In Tendons/Ligaments
    Ray Vanderby; Fiscal Year: 2010
    ..to non-invasively compute mechanical properties (nonlinear stiffness) and functional strains in ligaments and tendons. Mechanical properties can diagnose damage or a pathologic state (i.e...
  13. A Middle Ear Twist: Imaging, Physiology & Biomechanics
    RYAN PATRICK JACKSON; Fiscal Year: 2010
    ..At lower frequencies, the hinging mode is utilized due to the stiffness of the connecting ligaments and tendons. For smaller mammals, the impedance due to mass is not prohibitive at HF, so a twisting mode is not necessary...
  14. Collagen Diversity and Pathobiology in Skeletal Tissues
    David R Eyre; Fiscal Year: 2013
    ..protein that forms the structural framework of all major skeletal tissues in the body including bone, cartilages, tendons and ligaments...
  15. Use Of Adipose Derived Stem Cells For Engineering Of Ligament Tissue
    David McAllister; Fiscal Year: 2012
    ..the results of this research could be applied to engineering of other connective tissues including other tendons, fascia, and skin...
  16. Collagen I, Hyaluronan, and Aging
    May J Reed; Fiscal Year: 2011
    ..In the context of this clinical potential, we have recently found that ECM extracts from connective tissue (tendons) of aged mice contain significantly greater amounts of HA than that obtained from young mice...
  17. Structure and function of the fingers tendinous apparatus
    Francisco J Valero-Cuevas; Fiscal Year: 2013
    ..That is, we will confront the very challenge the nervous system faces by controlling the tendons of cadaveric fingers with an autonomous neuromechatronic system of microprocessors and motors that implements the ..
  18. Inflammation and Cardiovascular Disease in RA
    Andreas H Hielscher; Fiscal Year: 2013
    ..a chronic, progressive, systemic, inflammatory disease that primarily attacks peripheral joints and surrounding tendons and ligaments. This often very painful and debilitating disease affects approximately 1...
  19. Aging and IGF-1 Receptor in a three dimensional matrix
    Itay Bentov; Fiscal Year: 2013
    ..Collagen extracted from the tail tendons of mice can be polymerized into a 3-dimensional (3D) matrix that mimics the properties of dermal collagen in vivo...
  20. A Biomimetic Prehensile Digit for Upper-Limb Prostheses
    BRADLEY D VEATCH; Fiscal Year: 2011
    ..properties and functional characteristics of synthetic textile fibers to replicate key functions of ligaments, tendons, and cartilaginous articulations within the anatomical finger, along with "bone" elements fabricated from ..
  21. Patient Oriented Research and Mentoring Program in Orthopedics
    Elena Losina; Fiscal Year: 2013
    ..broad group of conditions with diverse etiologies that result in pain and functional impairment of bones, joints, tendons, ligaments and/or muscles...
  22. Combined Use of BMP-2 and Low Intensity Pulsed Ultrasound in Bone Regeneration
    AMARJIT SINGH VIRDI; Fiscal Year: 2010
    ..g., muscles, nerves, ligaments and tendons)...
  23. Fourth International MHE Research Conference
    Maurizio Pacifici; Fiscal Year: 2012
    ..to the growth plates of skeletal elements, impinge onto surrounding tissues and cause: compression of nerves and tendons with consequent pain and impairment of motion;chronic pain;skeletal deformities;and early onset osteoarthritis...
  24. Mechanisms underlying mechanical properties of muscle-tendon units
    Susan V Brooks; Fiscal Year: 2012
    ..The extensive changes with aging in mechanical properties of TA tendons occur with no major change in total collagen content...
  25. Enhanced Tendon Healing through Growth Factor and Cell Therapies
    Stavros Thomopoulos; Fiscal Year: 2013
    ..Early healing of flexor tendons relies on the migration of tendon surface cells and/or the extension of extrinsic cells from the synovial sheath ..
  26. Regulation of Tendon Extracellular Matrix Assembly by the Fibroblast Surfaceome
    Simone M L Smith; Fiscal Year: 2011
    ..For aims 1 and 2, tendons from wild type PI mice will be used...
  27. Rotator Cuff Degeneration and Repair
    Stavros Thomopoulos; Fiscal Year: 2013
    ..Degenerative changes can lead to massive, irreparable rotator cuff tears through attritional changes in the tendons and irreversible fatty degeneration of the rotator cuff muscles...
  28. An Exotendon Prosthesis to Improve Walking for Lower Limb Amputees
    BRIAN GLAISTER; Fiscal Year: 2012
    ..Borrowing from horse anatomy where short muscles interact with long tendons that stretch across multiple joints, exotendons can store energy and return it at a different time or even to a ..
  29. Mechanical System for Low Force Fatigue Tissue Testing
    Dawn M Elliott; Fiscal Year: 2010
    ..In particular, mechanical properties of bone, cartilage, tendons, ligaments, intervertebral disc, muscle, and neural soft tissue samples are evaluated, and the effect on ..
  30. Genetic and chemical screening in zebrafish to study tendon development
    Jenna L Galloway; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Tendons transmit force from the muscles to the bone, enabling movement, while ligaments connect bone to bone, providing stabilization...
  31. Quantitative UTE MR Imaging: Sensitive Biomarkers for Osteoarthritis
    Jiang Du; Fiscal Year: 2013
    ..A particular problem arises in MRI assessment because many joint tissues such as menisci, ligaments and tendons have T2s of only a few milliseconds...
  32. 2010 Proteoglycans Gordon Conference
    Robert J Linhardt; Fiscal Year: 2010
    ..systems including the formation and pathology of many parts of the musculoskeletal system such as muscle, bone, tendons and teeth...
  33. Origins of Elasticity and Viscoelasticity in Ligaments
    Jeffrey A Weiss; Fiscal Year: 2013
    ..function of the ground substance components as they relate to the hierarchical structure of ligaments and tendons. The micromechanical model will provide a framework to interpret the mechanical effects of alterations to ..
  34. Cross-scale interactions between mineral and collagen for tendon-bone attachment
    Stavros Thomopoulos; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Torn tendons and ligaments often require surgical repair to their bony insertions. A large percentage of these repairs have poor outcomes;for example, up to 94% of surgical rotator cuff repairs fail...
  35. Genetic and chemical screening in zebrafish to study tendon development
    Jenna L Galloway; Fiscal Year: 2013
    b>Tendons transmit force from muscles to bone, enabling movement, wfiile ligaments connect bone to bone, providing stabilization...
  36. Using BMSC-derived Bone-Ligament-Bone Tissue as a Live Template for ACL Regenerat
    Deneen M Wellik; Fiscal Year: 2013
    ..strategies involve grafts (allografts from cadavers or autografts of the patients'own patellar or hamstring tendons), although newer, more experimental treatments use engineered tissues that typically involve seeding cells on a ..
  37. A genetic system for the study of vertebrate limb regeneration
    Clifford J Tabin; Fiscal Year: 2011
    ..to the goal of being able to produce physiologically competent tissues, including cartilage, bone, muscle and tendons, the function of the musculoskeletal system requires that these tissues be organized and integrated with one ..
  38. Nanofiber Scaffolds with Gradations in Mineral Content for Rotator Cuff Repair
    Younan Xia; Fiscal Year: 2013
    ..continuous gradations in mineral content for rotator cuff repair - that is, surgical reattachment of the torn tendons to their bony insertions...
  39. Biomimetic Scaffold Anisotropy and Biomolecule Conjugation to Direct Tendon
    Brendan A Harley; Fiscal Year: 2013
    ..b>Tendons are specialized connective tissues that transmit tensile loads between muscle and bone whose functional capacity ..
  40. Mechanisms Impairing Finger Extension Following Stroke
    DEREK KAMPER; Fiscal Year: 2012
    ..Examine Effect of Joint Posture on Extension Neuromechanics. Finger extension is a complex process with tendons from 5 different muscles merging to form the extensor hood, an aponeurosis connected to the dorsal side of the ..
  41. REPAIR AND REHABILITATION OF FLEXOR TENDON INJURY
    Peter C Amadio; Fiscal Year: 2013
    ..glycoprotein ubiquitous in articular cartilage, but in some cases the healing process in lubricin treated tendons is delayed...
  42. Transcriptional regulation of tendon differentiation and matrix formation
    Ronen Schweitzer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tendons transmit the force generated by muscle contraction to the skeleton, through robust and highly organized bundles of collagen fibrils that establish the biomechanical properties of tendons...
  43. Structure Function Relationships at the Tendon to Bone Insertion Site
    Stavros Thomopoulos; Fiscal Year: 2010
    ..g., at the rotator cuff the recurrence of tears to repaired tendons has been reported to be as high as 94%3,7,8)...
  44. Mature &Aging Tendons: Extracellular Matrix Interactions in the Injury Response
    Louis J Soslowsky; Fiscal Year: 2012
    ..and biglycan in the re- establishment of structure and function during the repair response to injury in mature tendons and to define the effects of aging on decorin/biglycan mediated regulation of tendon repair...
  45. Innovative Tools for In Vivo Computational Prediction of Lumbar Stresses
    RICHARD DAVID KOMISTEK; Fiscal Year: 2010
    ..stresses at the bearing surface interfaces, ligament forces that provide constraint, and muscle forces (and tendons) of the vertebral bodies of the lower back...
  46. Regulation of Adult Tendon Growth and Regeneration by Scleraxis
    Christopher L Mendias; Fiscal Year: 2013
    ..Scleraxis is a bHLH transcription factor that is critical for the embryonic development of limb tendons, but little is known about scleraxis function in adult tendons...
  47. Non-invasive Morphologic and Biochemical Assessment of Tendon with Novel UTE-MRI
    Eric Y Chang; Fiscal Year: 2013
    ..as one of the imaging methods of choice for evaluation of soft tissues in the musculoskeletal system, including tendons. While this is the case, significant challenges in the diagnosis and characterization of pathology exist due to ..
  48. ELECTROSPINNING ARTIFICIAL LIGAMENTS AND TENDONS FOR POTENTIAL PROSTHESES
    JAVIER MACOSSAY-TORRES; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Over 800,000 injuries to ligaments, tendons and the joint capsule occur every year in the U.S.A...
  49. Stimulation of tendon repair by retinoid nuclear receptor agonists
    Motomi Enomoto-Iwamoto; Fiscal Year: 2013
    ..by applicant): There is an urgent need to create new and more effective therapies for tendon repair since injured tendons do not fully heal and regenerate...
  50. Role of Hox Genes in Integration of the Musculoskeletal System in Development
    Deneen M Wellik; Fiscal Year: 2013
    ..How Hox11 genes contribute to the formation and patterning of muscle groups, tendons and cartilage elements within the developing limb will be assessed using existing null alleles and fluorescent ..
  51. Regulation of Extracellular Matrix Assembly at the Myotendinous Junction
    Thomas F Schilling; Fiscal Year: 2013
    ..Muscles interact with tendons at their attachment sites, causing a reorganization of the extracellular matrix (ECM) into connective tissue ..
  52. On-line Ergonomics Solutions
    DAN MACLEOD; Fiscal Year: 2012
    ..A general class of conditions that involve the nerves, tendons, muscles, and supporting structures of the body...
  53. VAPOR GROWN CARBON FIBERS FOR BIOMEDICAL APPLICATIONS
    THOMAS APPLE; Fiscal Year: 1993
    ..Alternatively, surface roughness will be incorporated into the fibers when growth into tendons and muscle fibers is desired. This process will be carried out through controlled oxidation...
  54. Injectable Biomaterials to Modulate Protease Activity in Tendinopathy
    JOHNNA SUE TEMENOFF; Fiscal Year: 2013
    ..effects of sustained release of a protease inhibitor on the development of overuse injury in rat supraspinatus tendons. The proposed work is innovative because it employs a well-controlled, injectable carrier to achieve local, ..
  55. Regulated Assembly of the Tendon Extracellular Matrix
    David E Birk; Fiscal Year: 2013
    ..In addition, tendons have a limited capacity for regeneration and developmental paradigms may be applied to promote regenerative ..
  56. Dissection of the Salm Mediated Transcriptional Switch to Fibrillar Myogenesis
    Maria L Spletter; Fiscal Year: 2013
    ..conserved series of events, including myoblast generation and migration, myotube formation and attachment to tendons, sarcomerogenesis and myofiber maturation...
  57. "Recruitment of a Bone and Cancer Early Stage Investigator"
    D Rick Sumner; Fiscal Year: 2010
    ..of basic and translational researchers focusing on connective tissues, particularly bone, articular cartilage and tendons and ligaments...
  58. A Biomechanical Study of Work-Related Shoulder Disorder
    ANDREW ROBERT KARDUNA; Fiscal Year: 2010
    ..may initially manifest as diffuse shoulder pain, however, the vast majority reflect pathology of the rotator cuff tendons in the subacromial space...
  59. Ultrasonic analysis of the effects of aging on tendon mechanics
    Laura A Chernak; Fiscal Year: 2013
    ..for example, is a chronic degenerative condition which is common in the Achilles, patellar and quadriceps tendons, among others...
  60. The Role of Scleraxis and Mechanical Loading on Enthesis Maturation
    Megan Leigh Killian; Fiscal Year: 2013
    ..deletion of scleraxis (Scx), a transcription factor necessary for the development of force-transmitting tendons, leads to defects in enthesis formation...
  61. A Novel Approach to the Treatment of Cardiac Arrhythmia: A Robotic Catheter for E
    SHAPHAN REES JERNIGAN; Fiscal Year: 2011
    ..This tele-operated device uses computer- based controls to interpret joystick commands and to actuate the SMA tendons for accurate tracking of the commanded tip position...
  62. MUSCULOSKELETAL STIFFNESS AND LOCOMOTION
    CLAIRE FARLEY; Fiscal Year: 2000
    Muscles, tendons, and ligaments have spring-like characteristics. Because these musculoskeletal elements change length when joints flex or extend, it is not surprising that joints exhibit spring-like characteristics...
  63. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2009
    ..6) Based on 5) new genes will be constructed to match the properties needed for ligament and tendons. The past two years of work have produced a number of new genes, purified proteins and fibers from those proteins...
  64. STABILITY ANALYSIS OF THE DISTAL RADIO ULNAR JOINT
    Richard Berger; Fiscal Year: 1999
    ..deep and superficial heads), on joint stiffness will studied by applying various levels of force to the muscle tendons and remeasuring joint stiffness...
  65. Scalable Purification of Silk-Like Proteins from Transgenic Tobacco
    WILLIAM MARCOTTE; Fiscal Year: 2007
    ..This makes them desirable for biomedical applications such as artificial tendons and ligaments, cell scaffolds for bone and cartilage implants, and biodegradable micro-sutures...
  66. BIOLOGICAL ROLE OF LYSYL OXIDASE-2 IN MATRIX DEVELOPMENT
    Ian Hornstra; Fiscal Year: 1999
    ..collagen and elastin in the presence of molecular oxygen, producing the strong and flexible ligaments and tendons of large animal bodies...
  67. Durable Muscle-Prosthetic Bond for Artificial Tendons
    Natalia Juncosa Melvin; Fiscal Year: 2009
    ..Pilot studies have succeeded in the most demanding application possible, reattachment of the body's most powerful muscle, the quadriceps femoris and the proposal will expand that work in an extended term goat model. ..
  68. Rotator cuff tendon to bone insertion site healing
    Louis J Soslowsky; Fiscal Year: 2010
    The ability of rotator cuff tendons to heal back to bone following injury is limited, and failure of surgically repaired rotator cuff tears in humans has been reported in 20-70% of cases...
  69. Wrist Flexion to Identify Carpal Tunnel Syndrome
    ROBERT TUCKETT; Fiscal Year: 2001
    ..A major reason for ambiguity is that in its initial stages, CTS often involves inflammation of tendons transversing the wrist that control finger movement and grip...
  70. MUSCLE FUNCTION AFTER TENDON TRANSFER SURGERY
    Scott Delp; Fiscal Year: 2002
    ..Aim 2 will determine if forces at the proximal and distal tendons of the rectus femoris are equal after transfer, or if force at the distal tendon is disrupted after the surgery...
  71. Acupuncture and Low Back Pain during Pregnancy
    Shu Ming Wang; Fiscal Year: 2007
    ..GLBP is caused by enlargement of uterus, loosening of tendons and ligaments, and additional stress to the low back in pregnant women...
  72. Tendon formation mediated by SMAD8 signaling pathway
    David Kaplan; Fiscal Year: 2006
    ..The repair of torn tendons encounters major difficulties, and often results in impaired healing and function loss...