knee joint

Summary

Top Publications

  1. ncbi Osteoarthritis development in novel experimental mouse models induced by knee joint instability
    S Kamekura
    Department of Orthopaedic Surgery, University of Tokyo, Tokyo, Japan
    Osteoarthritis Cartilage 13:632-41. 2005
  2. pmc Grand challenge competition to predict in vivo knee loads
    Benjamin J Fregly
    Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida, USA
    J Orthop Res 30:503-13. 2012
  3. doi Loading of the knee joint during activities of daily living measured in vivo in five subjects
    I Kutzner
    Julius Wolff Institute, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    J Biomech 43:2164-73. 2010
  4. doi A human knee joint model considering fluid pressure and fiber orientation in cartilages and menisci
    K B Gu
    Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive, NW, Calgary, Alberta, Canada T2N 1N4
    Med Eng Phys 33:497-503. 2011
  5. pmc Responsiveness to change and reliability of measurement of radiographic joint space width in osteoarthritis of the knee: a systematic review
    W M Reichmann
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA, USA
    Osteoarthritis Cartilage 19:550-6. 2011
  6. doi Effect of superficial collagen patterns and fibrillation of femoral articular cartilage on knee joint mechanics-a 3D finite element analysis
    M E Mononen
    Department of Applied Physics, University of Eastern Finland, POB 1627, FI 70211 Kuopio, Finland
    J Biomech 45:579-87. 2012
  7. doi Gait kinematics and passive knee joint range of motion in children with hypermobility syndrome
    Francis A Fatoye
    Department of Health Professions, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, Elizabeth Gaskell Campus, Hathersage Road, Manchester M13 0JA, UK
    Gait Posture 33:447-51. 2011
  8. doi The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC): method description and recent developments
    Jan Philipp Benthien
    Department of Orthopaedic Surgery, University of Basel, Basel, Switzerland
    Knee Surg Sports Traumatol Arthrosc 19:1316-9. 2011
  9. doi Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo
    Tobias B Kurth
    University of Aberdeen, Aberdeen, UK
    Arthritis Rheum 63:1289-300. 2011
  10. doi Effect of a home program of hip abductor exercises on knee joint loading, strength, function, and pain in people with knee osteoarthritis: a clinical trial
    Elizabeth A Sled
    School of Rehabilitation Therapy, Queen s University, L D Acton Building, 31 George St, Kingston, Ontario, Canada K7L 3N6
    Phys Ther 90:895-904. 2010

Detail Information

Publications399 found, 100 shown here

  1. ncbi Osteoarthritis development in novel experimental mouse models induced by knee joint instability
    S Kamekura
    Department of Orthopaedic Surgery, University of Tokyo, Tokyo, Japan
    Osteoarthritis Cartilage 13:632-41. 2005
    ..To apply approaches from mouse genomics, this study created experimental mouse OA models by producing instability in the knee joints...
  2. pmc Grand challenge competition to predict in vivo knee loads
    Benjamin J Fregly
    Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida, USA
    J Orthop Res 30:503-13. 2012
    ....
  3. doi Loading of the knee joint during activities of daily living measured in vivo in five subjects
    I Kutzner
    Julius Wolff Institute, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    J Biomech 43:2164-73. 2010
    Detailed knowledge about loading of the knee joint is essential for preclinical testing of implants, validation of musculoskeletal models and biomechanical understanding of the knee joint...
  4. doi A human knee joint model considering fluid pressure and fiber orientation in cartilages and menisci
    K B Gu
    Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive, NW, Calgary, Alberta, Canada T2N 1N4
    Med Eng Phys 33:497-503. 2011
    ..The present study indicates the necessity of implementing the fluid pressure and anisotropic fibril reinforcement in articular cartilage for a more accurate understanding of the mechanics of the knee...
  5. pmc Responsiveness to change and reliability of measurement of radiographic joint space width in osteoarthritis of the knee: a systematic review
    W M Reichmann
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA, USA
    Osteoarthritis Cartilage 19:550-6. 2011
    ..The goal of this systematic review was to report the responsiveness to change and reliability of conventional radiographic joint space width (JSW) measurement...
  6. doi Effect of superficial collagen patterns and fibrillation of femoral articular cartilage on knee joint mechanics-a 3D finite element analysis
    M E Mononen
    Department of Applied Physics, University of Eastern Finland, POB 1627, FI 70211 Kuopio, Finland
    J Biomech 45:579-87. 2012
    ..of superficial collagen fibril patterns and collagen fibrillation of cartilage on stresses and strains within a knee joint. A 3D finite element model of a knee joint with cartilage and menisci was constructed based on magnetic ..
  7. doi Gait kinematics and passive knee joint range of motion in children with hypermobility syndrome
    Francis A Fatoye
    Department of Health Professions, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, Elizabeth Gaskell Campus, Hathersage Road, Manchester M13 0JA, UK
    Gait Posture 33:447-51. 2011
    ..The extent of passive knee joint range of motion (ROM) has also not been well reported in children with HMS...
  8. doi The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC): method description and recent developments
    Jan Philipp Benthien
    Department of Orthopaedic Surgery, University of Basel, Basel, Switzerland
    Knee Surg Sports Traumatol Arthrosc 19:1316-9. 2011
    ..This technical note describes the method of autologous matrix-induced chondrogenesis (AMIC), a one-step procedure combining subchondral microfracture with the fixation of a collagen I/III membrane with fibrin glue or sutures...
  9. doi Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo
    Tobias B Kurth
    University of Aberdeen, Aberdeen, UK
    Arthritis Rheum 63:1289-300. 2011
    ..We previously reported that human synovium contains cells that, after culture expansion, display properties of mesenchymal stem cells (MSCs). The objective of this study was to identify MSCs in native synovium in vivo...
  10. doi Effect of a home program of hip abductor exercises on knee joint loading, strength, function, and pain in people with knee osteoarthritis: a clinical trial
    Elizabeth A Sled
    School of Rehabilitation Therapy, Queen s University, L D Acton Building, 31 George St, Kingston, Ontario, Canada K7L 3N6
    Phys Ther 90:895-904. 2010
    ..Hip abductor muscle weakness may result in impaired frontal-plane pelvic control during gait, leading to greater medial compartment loading in people with knee osteoarthritis (OA)...
  11. pmc Patient satisfaction after total knee arthroplasty: who is satisfied and who is not?
    Robert B Bourne
    University Hospital, London Health Sciences Centre, University of Western Ontario, 339 Windermere Road, London, ON N6A 5A5, Canada
    Clin Orthop Relat Res 468:57-63. 2010
    ..7x greater risk), a low 1-year WOMAC (2.5x greater risk), preoperative pain at rest (2.4x greater risk) and a postoperative complication requiring hospital readmission (1.9x greater risk)...
  12. doi Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review
    Erlangga Yusuf
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:60-7. 2011
    ....
  13. pmc Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis
    Sunita Suri
    Academic Rheumatology, University of Nottingham, City Hospital, Hucknall Road, Nottingham, Notts NG5 1PB, UK
    Ann Rheum Dis 66:1423-8. 2007
    ..Normal adult articular cartilage is thought to be avascular and aneural...
  14. ncbi Correlation between the knee adduction torque and medial contact force for a variety of gait patterns
    Dong Zhao
    Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA
    J Orthop Res 25:789-97. 2007
    ..These results support the hypothesis that the knee adduction torque is highly correlated with medial compartment contact force and medial to total force ratio during gait...
  15. ncbi Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project
    Joanne M Jordan
    Thurston Arthritis Research Center and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7280, USA
    J Rheumatol 34:172-80. 2007
    ..To report contemporary estimates of the prevalence of knee-related osteoarthritis (OA) outcomes in African Americans and Caucasians aged > or = 45 years...
  16. pmc The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature
    John Bedson
    Arthritis Research Campaign National Primary Care Centre, Keele University, Staffordshire, ST5 5BG, United Kingdom
    BMC Musculoskelet Disord 9:116. 2008
    ....
  17. ncbi Knee joint kinematics in gait and other functional activities measured using flexible electrogoniometry: how much knee motion is sufficient for normal daily life?
    P J Rowe
    Department of Physiotherapy, Queen Margaret University College, EH6 8HF, Edinburgh, UK
    Gait Posture 12:143-55. 2000
    The knee joint kinematics of a group (n=20) of elderly normal subjects (mean age=67 years) were investigated using flexible electrogoniometry...
  18. ncbi The knee adduction moment during gait in subjects with knee osteoarthritis is more closely correlated with static alignment than radiographic disease severity, toe out angle and pain
    D E Hurwitz
    Department of Orthopedic Surgery, Rush Presbyterian St Luke s Medical Center, Rush Medical College of Rush University, Chicago, IL 60612, USA
    J Orthop Res 20:101-7. 2002
    ..moments, it only accounted for about 50% of its variation, emphasizing the need for a dynamic evaluation of the knee joint loading environment...
  19. ncbi Gait characteristics of patients with knee osteoarthritis
    K R Kaufman
    Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, MN, USA
    J Biomech 34:907-15. 2001
    ..This difference reflects the patient's compensation to reduce the knee joint loading. Further, subjects with OA and a higher body mass index have a lower knee extensor moment...
  20. doi Creep behavior of the intact and meniscectomy knee joints
    M Kazemi
    Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive, NW, Calgary, Alberta, Canada T2N 1N4
    J Mech Behav Biomed Mater 4:1351-8. 2011
    ..This creep behavior has not been investigated in whole knee joint modeling...
  21. pmc The osteoarthritis initiative: report on the design rationale for the magnetic resonance imaging protocol for the knee
    C G Peterfy
    Synarc Inc, San Francisco, CA 94105, USA
    Osteoarthritis Cartilage 16:1433-41. 2008
    ..To report on the process and criteria for selecting acquisition protocols to include in the osteoarthritis initiative (OAI) magnetic resonance imaging (MRI) study protocol for the knee...
  22. ncbi Increased knee joint loads during walking are present in subjects with knee osteoarthritis
    A J Baliunas
    Department of Orthopedic Surgery, Rush Medical College of Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Osteoarthritis Cartilage 10:573-9. 2002
    ..adduction moment can be used to assess the load distribution between the medial and lateral compartments of the knee joint. Additionally, this study tests if changes in the knee angles, such as a reduced midstance knee flexion angle, ..
  23. ncbi Correlation of power Doppler sonography with vascularity of the synovial tissue of the knee joint in patients with osteoarthritis and rheumatoid arthritis
    M Walther
    University of Wuerzburg, Germany
    Arthritis Rheum 44:331-8. 2001
    ..To examine the significance of power Doppler sonography (PDS) in the diagnosis of synovial hypertrophy of the knee joint by verifying and comparing the PDS findings with histopathologic findings of synovial membrane vascularity...
  24. doi Independent drilling outperforms conventional transtibial drilling in anterior cruciate ligament reconstruction
    Mark E Steiner
    Sports Medicine Section, Orthopaedic Department, New England Baptist Hospital, Boston, Massachusetts 02120, USA
    Am J Sports Med 37:1912-9. 2009
    ..Optimal tunnel placement is critical in anterior cruciate ligament reconstructive surgery, yet the method used to drill the tunnels may compromise their placement...
  25. ncbi The effect of graft tensioning in anatomic 2-bundle ACL reconstruction on knee joint kinematics
    Yuichi Hoshino
    Department of Orthopaedic Surgery, Kobe University, Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Hyogo, 650 0017, Japan
    Knee Surg Sports Traumatol Arthrosc 15:508-14. 2007
    ....
  26. ncbi Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients
    X Ayral
    Service de Rhumatologie B, Hopital Cochin, AP HP, Universite Rene Descartes, Paris, France
    Osteoarthritis Cartilage 13:361-7. 2005
    ..To evaluate the prevalence of synovitis in painful medial tibiofemoral knee osteoarthritis (OA) and to evaluate correlation between synovitis and the structural severity and progression of tibiofemoral cartilage damage...
  27. doi Assessment of movement-evoked pain in osteoarthritis by the knee-bend and CatWalk tests: a clinically relevant study
    Joana Ferreira-Gomes
    Institute of Histology and Embryology, Faculty of Medicine and IBMC, University of Porto, Porto, Portugal
    J Pain 9:945-54. 2008
    ..The aim of this study was to investigate pain-related behaviors on the affected knee joint, the primary source of nociception, in animals with mono-iodoacetate-induced OA, using the knee-bend (which ..
  28. ncbi A brief screening tool for knee pain in primary care (KNEST). 2. Results from a survey in the general population aged 50 and over
    C Jinks
    Primary Care Sciences Research Centre, Keele University, UK
    Rheumatology (Oxford) 43:55-61. 2004
    ..To use a brief screening tool to identify knee pain (all knee pain, non-chronic and chronic knee pain) and associated health-care use in the general population aged 50 yr and over...
  29. ncbi Primary care treatment of knee pain--a survey in older adults
    M Porcheret
    Primary Care Musculoskeletal Research Centre, Primary Care Sciences, Keele University, Keele, Staffs ST5 5BG, UK
    Rheumatology (Oxford) 46:1694-700. 2007
    ..To describe the treatment of knee pain in older adults in primary care and to compare reported practice with published evidence...
  30. ncbi A framework for the in vivo pathomechanics of osteoarthritis at the knee
    Thomas P Andriacchi
    Department of Mechanical Engineering, Stanford University, Division of Biomechanical Engineering, Stanford, CA 94305 4038, USA
    Ann Biomed Eng 32:447-57. 2004
    ..The integrated in vivo framework presented here will be helpful for the interpretation of laboratory experiments as well as for the development of new methods for the evaluation of OA at the knee...
  31. doi Functional calibration procedure for 3D knee joint angle description using inertial sensors
    J Favre
    Ecole Polytechnique Federale de Lausanne EPFL, Laboratory of Movement Analysis and Measurement, Lausanne, Switzerland
    J Biomech 42:2330-5. 2009
    Measurement of three-dimensional (3D) knee joint angle outside a laboratory is of benefit in clinical examination and therapeutic treatment comparison...
  32. doi Lifetime risk of symptomatic knee osteoarthritis
    Louise Murphy
    Business Computer Applications, Atlanta, Georgia, USA
    Arthritis Rheum 59:1207-13. 2008
    ..To estimate the lifetime risk of symptomatic knee osteoarthritis (OA), overall and stratified by sex, race, education, history of knee injury, and body mass index (BMI)...
  33. ncbi Soft-tissue balancing during total knee arthroplasty in the varus knee
    William M Mihalko
    Adult Reconstructive Research, Department of Orthopaedic Surgery, University of Tennessee Campbell Clinic, Memphis, Tennessee 38017, USA
    J Am Acad Orthop Surg 17:766-74. 2009
    ..balancing during total knee arthroplasty is an important step in optimizing the mechanical balance of the knee joint. Soft-tissue contractures that result from varus coronal plane deformity can pose a difficult problem, and the ..
  34. doi An intraoperatively moulded PMMA prostheses like spacer for two-stage revision of infected total knee arthroplasty
    Sandro Kohl
    Department of Orthopaedic Surgery, Inselspital, University of Bern, Switzerland
    Knee 18:464-9. 2011
    ..The use of this spacer is a time sparing, cheap and convenient option in 2-stage TKA revision...
  35. doi Proprioception in knee osteoarthritis: a narrative review
    J Knoop
    Reade, Centre of Rehabilitation and Rheumatology formerly Jan van Breemen Instituut, Department of Rehabilitation Research, Amsterdam, The Netherlands
    Osteoarthritis Cartilage 19:381-8. 2011
    ..To give an overview of the literature on knee proprioception in knee osteoarthritis (OA) patients...
  36. ncbi A finite element model of the human knee joint for the study of tibio-femoral contact
    Tammy L Haut Donahue
    Department of Mechanical Engineering, Michigan Technological University, Houghton 49931, USA
    J Biomech Eng 124:273-80. 2002
    ..the goals of this study were 1) to develop a geometrically accurate three-dimensional solid model of the knee joint with special attention given to the menisci and articular cartilage, 2) to determine to what extent bony ..
  37. ncbi Secondary gait changes in patients with medial compartment knee osteoarthritis: increased load at the ankle, knee, and hip during walking
    Annegret Mundermann
    Stanford University Medical Center, Stanford, California 94305 4038, USA
    Arthritis Rheum 52:2835-44. 2005
    ..This study tested the hypothesis that gait changes related to knee osteoarthritis (OA) of varied severity are associated with increased loads at the ankle, knee, and hip...
  38. pmc Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis
    Niklas Schuelert
    Department of Physiology and Pharmacology, University of Calgary, 3330, Hospital Drive NW, Calgary, AB, T2N 4N1, Canada
    Arthritis Res Ther 14:R5. 2012
    ..The present study examined whether local application of A-803467, a selective blocker of the Nav 1.8 sodium channel, can reduce nociceptive transmission from the joint in a rodent model of osteoarthritis (OA)...
  39. doi Reduced knee joint moment in ACL deficient patients at a cost of dynamic stability during landing
    Kai Daniel Oberländer
    Institute of Biomechanics and Orthopaedics, German Sport University Cologne, Germany
    J Biomech 45:1387-92. 2012
    ..05) and we found a significant correlation between moment arms at the knee joint and trunk angle (r² = 0.48;p<0.01)...
  40. doi Increase in outpatient knee arthroscopy in the United States: a comparison of National Surveys of Ambulatory Surgery, 1996 and 2006
    Sunny Kim
    Department of Orthopaedic Surgery, University of California Davis, 4860 Y Street, Suite 3800, Sacramento, CA 95817, USA
    J Bone Joint Surg Am 93:994-1000. 2011
    ..This study was proposed to investigate the changes in the utilization of knee arthroscopy in an ambulatory setting over the past decade in the United States as well as its implications...
  41. pmc Estimation of quasi-stiffness of the human knee in the stance phase of walking
    Kamran Shamaei
    Department of Mechanical Engineering and Materials Science, School of Engineering and Applied Science, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 8:e59993. 2013
    ..The knee joint moment-angle relationship is approximately linear in the flexion and extension stages of stance, exhibiting ..
  42. doi Inertial sensor-based knee flexion/extension angle estimation
    Glen Cooper
    Centre for Rehabilitation and Human Performance Research, University of Salford, UK
    J Biomech 42:2678-85. 2009
    A new method for estimating knee joint flexion/extension angles from segment acceleration and angular velocity data is described...
  43. pmc Anterior cruciate ligament changes in the human knee joint in aging and osteoarthritis
    Akihiko Hasegawa
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Arthritis Rheum 64:696-704. 2012
    ....
  44. pmc Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score)
    D J Hunter
    Rheumatology Department, Royal North Shore Hospital, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia
    Osteoarthritis Cartilage 19:990-1002. 2011
    ..The purpose of this report is to describe the instrument and its reliability...
  45. doi Prediction of range of motion 2 years after mobile-bearing total knee arthroplasty: PCL-retaining versus PCL-sacrificing
    Yoshinori Ishii
    Ishii Orthopaedic and Rehabilitation Clinic, 1089 Shimo Oshi, Gyoda, Saitama, 361 0037, Japan
    Knee Surg Sports Traumatol Arthrosc 19:2002-8. 2011
    ..This study evaluated the changes in the range of motion (ROM) with time postoperatively...
  46. pmc Massive weight loss-induced mechanical plasticity in obese gait
    Tibor Hortobagyi
    Department of Exercise and Sport Science, East CarolinaUniversity, Greenville, North Carolina, USA
    J Appl Physiol (1985) 111:1391-9. 2011
    ..There may be a weight loss threshold of 30 kg limiting changes in gait kinematics. Implications for exercise prescription are also discussed...
  47. doi Muscle and external load contribution to knee joint contact loads during normal gait
    C R Winby
    School of Sport Science, Exercise and Health, University of Western Australia, M408 35 Stirling Hwy, Crawley, WA 6009, Australia
    J Biomech 42:2294-300. 2009
    ..osteoarthritis and it has been proposed that these moments increase the load on the medial compartment of the knee joint. However, this mechanism cannot be validated without taking into account the internal forces and moments ..
  48. doi Delineating the impact of obesity and its relationship on recovery after total joint arthroplasties
    C A Jones
    School of Public Health, University of Alberta, Edmonton, AB, Canada T6G 2G4
    Osteoarthritis Cartilage 20:511-8. 2012
    ....
  49. doi Phenotypic alterations of neurons that innervate osteoarthritic joints in rats
    Joana Ferreira-Gomes
    University of Porto, Porto, Portugal
    Arthritis Rheum 62:3677-85. 2010
    ..mechanisms of nociception in OA, we studied the expression of the phenotype markers calcitonin gene-related peptide (CGRP), isolectin B4 (IB4), and neurofilament 200 (NF200) in sensory neurons innervating the OA knee joint in rats.
  50. doi Autologous chondrocyte implantation: a systematic review
    Joshua D Harris
    Division of Sports Medicine Cartilage Repair Center, Department of Orthopaedics, The Ohio State University Sports Medicine Center, 2050 Kenny Road, Suite 3100, Columbus, OH 43221 3502, USA
    J Bone Joint Surg Am 92:2220-33. 2010
    ....
  51. doi Does greater knee flexion increase patient function and satisfaction after total knee arthroplasty?
    Brandon N Devers
    Baylor College of Medicine, Houston, Texas 77030, USA
    J Arthroplasty 26:178-86. 2011
    ..This suggests that increased knee flexion, particularly more than 130°, may lead to improved outcomes after TKA...
  52. pmc Autologous platelet gel for tissue regeneration in degenerative disorders of the knee
    Marcello Napolitano
    Immunohaematology and Transfusion Medicine Unit, Cosenza Hospital, Cosenza, Italy
    Blood Transfus 10:72-7. 2012
    ..The refinement of the use of platelet-derived growth factors that has occurred over the last decade has led to a broadening of the fields of use, in particular for new treatments in orthopaedics aimed at improving tissue regeneration...
  53. ncbi An EMG-driven musculoskeletal model to estimate muscle forces and knee joint moments in vivo
    David G Lloyd
    School of Human Movement and Exercise Science, University of Western Australia, Perth, 35 Stirling Highway, Crawley, WA 6009, Australia
    J Biomech 36:765-76. 2003
    ..Muscle-tendon lengths and moment arms of 13 muscles crossing the knee joint were determined from joint kinematics using a three-dimensional anatomical model of the lower limb...
  54. doi A prospective, randomized clinical study of osteochondral autologous transplantation versus microfracture for the treatment of osteochondritis dissecans in the knee joint in children
    Rimtautas Gudas
    Kaunas University of Medicine, Kaunas, Lithuania
    J Pediatr Orthop 29:741-8. 2009
    ..mosaic-type osteochondral autologous transplantation (OAT) and microfracture (MF) procedures for the treatment of osteochondritis dissecans (OCD) defects of the femoral condyles of the knee joint in children under the age of 18 years.
  55. doi Definition and classification of early osteoarthritis of the knee
    Frank P Luyten
    Division of Rheumatology, Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, O and N 1, Herestraat 49, Bus 813, 3000, Leuven, Belgium
    Knee Surg Sports Traumatol Arthrosc 20:401-6. 2012
    ..Here, classification criteria for this group of patients are presented, allowing a more defined and accurate inclusion in clinical trials in the future...
  56. doi Treatment of chondral defects of the knee with one step matrix-assisted technique enhanced by autologous concentrated bone marrow: in vitro characterisation of mesenchymal stem cells from iliac crest and subchondral bone
    Laura de Girolamo
    Orthopaedic Biotechnologies Lab, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy
    Injury 41:1172-7. 2010
    ..Although the AMIC(®) approach has many advantages, the surgical technique in the application of the microfracture technique remains essential and affects the final result...
  57. doi Can single limb support objectively assess the functional severity of knee osteoarthritis?
    Avi Elbaz
    AposTherapy Research Group, Herzliya, Israel
    Knee 19:32-5. 2012
    ..These results suggest that single-limb support quintiles may be added as an additional scale for generally assessing the symptomatic stage of KOA...
  58. pmc Validity and inter-rater reliability of medio-lateral knee motion observed during a single-limb mini squat
    Eva Ageberg
    Department of Orthopedics, Clinical Sciences Lund, Lund University, Sweden
    BMC Musculoskelet Disord 11:265. 2010
    ..The aim was to validate an observational clinical test of assessing the medio-lateral knee motion, using a three-dimensional (3-D) motion analysis system. In addition, the inter-rater reliability was evaluated...
  59. doi An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee
    Robert J Buck
    StatAnswers Consulting LLC, San Diego, California 92122, USA
    Magn Reson Med 63:680-90. 2010
    ..These variables hence define an efficient subset for describing structural status and change in osteoarthritic cartilage...
  60. doi Osteoarthritis year 2010 in review: imaging
    D Hayashi
    Department of Radiology, Boston University School of Medicine, Boston, MA 02118, USA
    Osteoarthritis Cartilage 19:354-60. 2011
    ..ongoing using conventional radiography with a focus on measurements of joint space width and alignment of the knee joint. Ultrasound is emerging as a useful imaging technique, particularly in the field of hand OA research...
  61. pmc Type III collagen, a fibril network modifier in articular cartilage
    Jiann Jiu Wu
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 285:18537-44. 2010
    ....
  62. ncbi Effects of increasing tibial slope on the biomechanics of the knee
    J Robert Giffin
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Sports Med 32:376-82. 2004
    ..To determine the effects of increasing anterior-posterior (A-P) tibial slope on knee kinematics and in situ forces in the cruciate ligaments...
  63. doi Treatment of anterior cruciate ligament injuries with special reference to graft type and surgical technique: an assessment of randomized controlled trials
    Kristian Samuelsson
    Department of Orthopaedics, Sahlgrenska University Hospital, SE 431 80, Molndal, Sweden
    Arthroscopy 25:1139-74. 2009
    ..The secondary aims were to identify the relative strengths and weaknesses of the selected studies, to resolve contradictions in the literature, and to evaluate the need for further studies...
  64. pmc The Knee Clinical Assessment Study-CAS(K). A prospective study of knee pain and knee osteoarthritis in the general population: baseline recruitment and retention at 18 months
    George Peat
    Primary Care Sciences Research Centre, Keele University, Keele, North Staffordshire, ST5 5BG, UK
    BMC Musculoskelet Disord 7:30. 2006
    ..We investigated these matters in the context of baseline recruitment and retention at 18 months of participants for a prospective observational cohort study of knee pain and knee osteoarthritis in the general population...
  65. doi Does accurate anatomical alignment result in better function and quality of life? Comparing conventional and computer-assisted total knee arthroplasty
    Peter F Choong
    Department of Orthopaedics, St Vincent s Hospital, University of Melbourne, Melbourne, Victoria, Australia
    J Arthroplasty 24:560-9. 2009
    ..Computer-assisted total knee arthroplasty achieves greater accuracy in implant alignment and this correlates with better knee function and improved quality of life...
  66. ncbi In situ compressive stiffness, biochemical composition, and structural integrity of articular cartilage of the human knee joint
    T Franz
    Institute of Pathology, University of Bern, Bern, Switzerland
    Osteoarthritis Cartilage 9:582-92. 2001
    ..a hand-held indentation probe has recently been developed and baseline data for macroscopically normal knee joint cartilage were provided. However, the histological stage of degeneration of the measured cartilage was not known...
  67. pmc A second decade lifetable survival analysis of the Oxford unicompartmental knee arthroplasty
    Andrew J Price
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK
    Clin Orthop Relat Res 469:174-9. 2011
    ..Long-term second decade results are required to establish if the design aim can be met...
  68. ncbi Treatment of knee pain in older adults in primary care: development of an evidence-based model of care
    M Porcheret
    Primary Care Musculoskeletal Research Centre, Primary Care Sciences, Keele University, Keele, Staffs ST5 5BG, UK
    Rheumatology (Oxford) 46:638-48. 2007
    ..To develop a stepped model of care for the treatment of knee pain in older adults in primary care based on recommended interventions...
  69. pmc Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis
    C Pauli
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Osteoarthritis Cartilage 19:1132-41. 2011
    ..The objectives of this study were to (1) establish standardized protocols for representative macroscopic and microscopic analysis, (2) improve existing scoring systems, and (3) apply these techniques to a large number of human menisci...
  70. ncbi Identification of passive elastic joint moments in the lower extremities
    R Riener
    Institute of Automatic Control Engineering, Technical University of Munich, Germany
    J Biomech 32:539-44. 1999
    ..The model can be implemented in biomechanical models of the lower extremities, which are generally used for the simulation of multi-joint movements such as standing-up, walking, running, or jumping...
  71. ncbi The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis
    Thomas P Andriacchi
    Department of Mechanical Engineering, Biomechanical Engineering, Stanford University, Stanford, CA 94305, USA
    Curr Opin Rheumatol 18:514-8. 2006
    ..This review examines recent in-vivo studies of ambulation and discusses the fundamental role of mechanics of ambulation in the initiation and progression of osteoarthritis at the knee...
  72. ncbi Explicit finite element modeling of total knee replacement mechanics
    Jason P Halloran
    University of Denver, 2390 S York, Denver, CO 80208, USA
    J Biomech 38:323-31. 2005
    ..These analyses have shown that, at low computational cost, a force-control dynamic simulation of a gait cycle can yield useful and predictable results...
  73. ncbi A three-dimensional finite element analysis of the combined behavior of ligaments and menisci in the healthy human knee joint
    E Pena
    Group of Structural Mechanics and Material Modelling, Aragon Institute of Engineering Research I3A, University of Zaragoza, Maria de Luna, 3, E 50018 Zaragoza, Spain
    J Biomech 39:1686-701. 2006
    ..The results obtained reproduce the complex, nonuniform stress and strain fields that occur in the biological soft tissues involved and the kinematics of the human knee joint under a physiological external load.
  74. ncbi Muscle performance during maximal isometric and dynamic contractions is influenced by the stiffness of the tendinous structures
    Jens Bojsen-Møller
    Institute of Sports Medicine Copenhagen Team Danmark Test Center, Bispebjerg Bakke, 23, bygn 8, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 99:986-94. 2005
    ....
  75. pmc Evidence of abnormal lower-limb torque coupling after stroke: an isometric study
    Theresa Hayes Cruz
    Department of Biomedical Engineering, Northwestern University, Chicago, IL, USA
    Stroke 39:139-47. 2008
    ..Although stroke survivors often display abnormal joint torque patterns, studies of torque-coupling in the lower limb are lacking, despite their potential impact on gait abnormalities...
  76. ncbi Gait analysis of patients following total knee replacement: a systematic review
    Jodie A McClelland
    Musculoskeletal Research Centre, La Trobe University, Melbourne, Victoria 3086, Australia
    Knee 14:253-63. 2007
    ..The substantial methodologic differences between studies may contribute to the inconsistencies in reported findings for many gait outcomes. Future research is needed to determine the clinical relevance of these findings...
  77. ncbi Correlation of maximum flexion with clinical outcome after total knee replacement in Asian patients
    K K Park
    Joint Reconstruction Center, Seoul National University, Bundang Hospital, 300 Gumi dong, Bundang gu, Seongnam si, Gyeonggi do 463 707, Seoul, Korea
    J Bone Joint Surg Br 89:604-8. 2007
    ..Efforts to increase post-operative maximum flexion should be exercised with caution until concerns relating to high-flexion activities are sufficiently resolved...
  78. pmc Decreased knee adduction moment does not guarantee decreased medial contact force during gait
    Jonathan P Walter
    Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida, USA
    J Orthop Res 28:1348-54. 2010
    ..93). Future studies that evaluate the effectiveness of gait modifications for offloading the medial compartment of the knee should consider the combined effect of these two knee moments...
  79. ncbi Tibio-femoral movement in the living knee. A study of weight bearing and non-weight bearing knee kinematics using 'interventional' MRI
    P Johal
    Department of Orthopaedics, St Mary s Hospital, W2 1NY London, UK
    J Biomech 38:269-76. 2005
    ....
  80. pmc Changes in in vivo knee loading with a variable-stiffness intervention shoe correlate with changes in the knee adduction moment
    Jennifer C Erhart
    Department of Mechanical Engineering, Stanford University, Stanford, California, USA
    J Orthop Res 28:1548-53. 2010
    ..The reductions in the external knee adduction moment are indicative of reductions in in vivo medial compressive force with this intervention...
  81. pmc Acoustic stiffness and change in plug cartilage over time after autologous osteochondral grafting: correlation between ultrasound signal intensity and histological score in a rabbit model
    Hiroshi Kuroki
    Department of Orthopaedic Surgery, School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Arthritis Res Ther 6:R492-504. 2004
    ....
  82. ncbi The influence of foot progression angle on the knee adduction moment during walking and stair climbing in pain free individuals with knee osteoarthritis
    Mengtao Guo
    Center for Biomedical Engineering Research, Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, United States
    Gait Posture 26:436-41. 2007
    ..No significant differences were noted during stair descent. These results suggest that walking with a toe-out strategy may benefit persons with early stages of medial knee OA...
  83. ncbi Effects of pulsed electromagnetic fields on patients' recovery after arthroscopic surgery: prospective, randomized and double-blind study
    C Zorzi
    Sacro Cuore Don Calabria Hospital, Via don A Sempreboni 5, 37024 Negrar Vr, Italy
    Knee Surg Sports Traumatol Arthrosc 15:830-4. 2007
    ..05). Treatment with I-ONE aided patient recovery after arthroscopic surgery, reduced the use of NSAIDs, and also had a positive long-term effect...
  84. doi Systematic review of single-bundle anterior cruciate ligament reconstruction outcomes: a baseline assessment for consideration of double-bundle techniques
    Paul B Lewis
    Division of Sports Medicine, Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Sports Med 36:2028-36. 2008
    ..Challenging this comparison, however, has been the lack of an established consensus on the success of single-bundle reconstruction...
  85. doi Increased failure rate of autologous chondrocyte implantation after previous treatment with marrow stimulation techniques
    Tom Minas
    Cartilage Repair Center, Brigham and Women s Hospital, Harvard Medical School, 850 Boylston Street, Chestnut Hill, MA 02467, USA
    Am J Sports Med 37:902-8. 2009
    ..Common knowledge holds that these treatments do not compromise subsequent cartilage repair procedures with autologous chondrocyte implantation...
  86. doi Gender differences exist in the hip joint moments of healthy older walkers
    Katherine A Boyer
    VA Palo Alto Health Care System, Bone and Joint Rehabilitation R and D Center of Excellence, Palo Alto, CA 94304, USA
    J Biomech 41:3360-5. 2008
    ..This is in favor of a hypothesis that the increased joint contact stress in a female population could contribute to a greater joint degeneration at the hip in females as compared with males...
  87. ncbi The effect of anterior cruciate ligament injury on knee joint function under a simulated muscle load: a three-dimensional computational simulation
    Guoan Li
    Orthopaedic Biomechanics Laboratory, Harvard Medical School, Massachusetts General Hospital Beth Israel Deaconess Medical Center, Boston 02215, USA
    Ann Biomed Eng 30:713-20. 2002
    ....
  88. ncbi Double-bundle ACL reconstruction can improve rotational stability
    Masayoshi Yagi
    Department of Orthopaedic Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Clin Orthop Relat Res 454:100-7. 2007
    ..However, using the new measurement system, patients with double-bundle ACL reconstruction showed better pivot shift control of complex instability than patients with anteromedial and posterolateral single-bundle reconstruction...
  89. doi A systematic review of the femoral origin and tibial insertion morphology of the ACL
    Sebastian Kopf
    Department of Orthopaedic Surgery, University of Pittsburgh, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Knee Surg Sports Traumatol Arthrosc 17:213-9. 2009
    ..This study is a systematic review of the morphology of the ACL femoral origin and tibial insertion as reported in the literature...
  90. pmc AQUILA: assessment of quality in lower limb arthroplasty. An expert Delphi consensus for total knee and total hip arthroplasty
    Bart G Pijls
    Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands, Albinusdreef 2, Leiden, The Netherlands
    BMC Musculoskelet Disord 12:173. 2011
    ..A Delphi approach was used to develop a checklist for reporting quality, methodological quality and generalizability of case series and cohorts in total hip and total knee arthroplasty with a focus on aseptic loosening...
  91. ncbi Differential diagnosis of tumours and tumour-like lesions of the infrapatellar (Hoffa's) fat pad: pictorial review with an emphasis on MR imaging
    C Helpert
    Department of Radiology, MRI Centre, Royal Orthopaedic Hospital, Birmingham B31 2AP, UK
    Eur Radiol 14:2337-46. 2004
    ..This pictorial review illustrates the spectrum of mass-like lesions that can affect the IFP, emphasizing the radiographic and MR findings that suggest a specific diagnosis...
  92. doi Treatment of articular cartilage lesions of the knee joint using a modified AMIC technique
    Antonio Pascarella
    Laboratorio di Chirurgia Artroscopica, Via Teodoro La Cava 36, Isernia, Italy
    Knee Surg Sports Traumatol Arthrosc 18:509-13. 2010
    ..The collagen membrane forms the roof of a 'biological chamber', and serves to protect and contains the stem cells as they differentiate into chondrocytes, which will form a healthy regenerative cartilage...
  93. ncbi High tibial osteotomy for medial compartment osteoarthritis
    G S E Dowd
    Department of Orthopaedics, Royal Free Hospital, Pond Street, London NW3 2QG, UK
    Knee 13:87-92. 2006
    ..An attempt has been made to incorporate important technical considerations, recent developments and other treatment options in this condition...
  94. ncbi Immediate effects of a controllable knee ankle foot orthosis for functional compensation of gait in patients with proximal leg weakness
    Juan C Moreno
    Bioengineering Group, Industrial Automation Institute of the Spanish National Research Council, CSIC, Carretera Campo Real, Madrid, Spain
    Med Biol Eng Comput 46:43-53. 2008
    Application of intermittent control of the knee joint stiffness in a knee ankle foot orthosis (KAFO) during gait is proposed...
  95. ncbi Is there a functional benefit to obtaining high flexion after total knee arthroplasty?
    Robert Michael Meneghini
    St Vincent Center for Joint Replacement, Indianapolis, Indiana 46260, USA
    J Arthroplasty 22:43-6. 2007
    ..02). Obtaining flexion greater than 125 degrees after TKA does not offer a benefit in overall knee function. However, obtaining a high degree of flexion appears to optimize stair climbing...
  96. ncbi Joint torques and dynamic joint stiffness in elderly and young men during stepping down
    Sally D Lark
    Active Life Span Research, Manchester Metropolitan University, Alsager ST7 2HL, UK
    Clin Biomech (Bristol, Avon) 18:848-55. 2003
    ..To compare the joint torque pattern and dynamic joint stiffness at the knee and ankle in elderly and young men during stepping down...
  97. doi Influence of knee flexion angle on femoral tunnel characteristics when drilled through the anteromedial portal during anterior cruciate ligament reconstruction
    Georges Basdekis
    Department of Orthopaedic Surgery, University Hospital of Larissa, Medical School, University of Thessalia, Larissa, Greece
    Arthroscopy 24:459-64. 2008
    ....
  98. doi Risk factors for a contralateral anterior cruciate ligament injury
    Per Swärd
    Department of Orthopaedics, Lund University and Lund University Hospital, 221 85 Lund, Sweden
    Knee Surg Sports Traumatol Arthrosc 18:277-91. 2010
    ..This literature review indicates that the increased risk of sustaining a contralateral ACL injury should be contemplated, when considering the return to a high level of activity after an ACL injury...
  99. doi The microfracture technique for the treatment of full-thickness articular cartilage lesions of the knee: midterm results
    Mehmet Asik
    Medical Faculty of Istanbul, University of Istanbul, Istanbul, Turkey
    Arthroscopy 24:1214-20. 2008
    ..The purpose of this study was to determine the effectiveness of the microfracture technique in the treatment of full-thickness articular cartilage lesions of the knee...
  100. doi Quantitative T2 mapping of knee cartilage: differentiation of healthy control cartilage and cartilage repair tissue in the knee with unloading--initial results
    Tallal C Mamisch
    Department of Orthopedic Surgery, University of Berne, Berne, Switzerland
    Radiology 254:818-26. 2010
    ..on T2 cartilage maps the effect of unloading during a clinical magnetic resonance (MR) examination in the postoperative follow-up of patients after matrix-associated autologous chondrocyte transplantation (MACT) of the knee joint.
  101. pmc Active and passive contributions to joint kinetics during walking in older adults
    Amy Silder
    Department of Biomedical Engineering, University of Wisconsin Madison, Madison, WI 53706, USA
    J Biomech 41:1520-7. 2008
    ..The results of this study suggest that age-related shifts in joint kinetics do not arise as a result of increased passive hip joint stiffness, but seem to be reflected in plantar-flexor weakness...

Research Grants65

  1. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    ..and pathophysiology of osteoarthritis with a primary focus on the biochemical and biomechanical changes in the knee joint and articular cartilage;3) Acquire background knowledge and technical skills relevant to the development of knee ..
  2. A new experimental model of knee joint trauma
    TAMMY L HAUTDONAHUE; Fiscal Year: 2012
    ..Treatment of these injuries, particularly to the knee joint, is paramount in the retention of a healthy lifestyle...
  3. Predicting cell deformation from body level mechanical loads
    Ahmet Erdemir; Fiscal Year: 2012
    ..Multiresolution models of the knee joint, representative of joint, tissue and cell structure and mechanics, will be developed for this purpose...
  4. Angiogenesis and Long-term Bone and Joint Allotransplant Survival
    Allen T Bishop; Fiscal Year: 2012
    ..Following whole knee joint transplants in a rabbit model, mechanical properties of joint cartilage and kinematic analysis of joint function ..
  5. Common mechanisms of Osteoarthritis in three mouse models
    Robert E Seegmiller; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This study in three murine models will provide biomolecular insight into the pathogenesis of OA and pave the way for future investigations into the use of various drug and gene-based therapies. ..
  6. Musculoskeletal Biomechanics of Gradient Walking in Obese Adults
    RAYMOND CLIFTON BROWNING; Fiscal Year: 2012
    ..We hypothesize that for obese adults, slow walking up a moderate incline minimizes knee joint loads while optimizing caloric expenditure and cardiovascular stimulus...
  7. Use Of Adipose Derived Stem Cells For Engineering Of Ligament Tissue
    David McAllister; Fiscal Year: 2012
    ..In addition, there is evidence to suggest the knee joint will deteriorate if left untreated...
  8. The role of microRNAs in chondrogenesis and arthritis
    Hiroshi Asahara; Fiscal Year: 2009
    ..miR-140 null mice showed a phenotype in skeletal framework and also earlier onset of osteoarthritic changes in knee joint at 6 months...
  9. The role of microRNAs in chondrogenesis and arthritis
    Hiroshi Asahara; Fiscal Year: 2013
    ..miR-140 null mice showed earlier onset of osteoarthritic changes in knee joint at 6 months...
  10. Intrinsic Repair of the Knee Meniscus
    Farshid Guilak; Fiscal Year: 2011
    ..The menisci are intra-articular fibrocartilaginous structures essential to the normal function of the knee joint. Damage or loss of the menisci often results in progressive osteoarthritic degeneration of the articular ..
  11. Tai Chi for Knee Osteoarthritis
    Chenchen Wang; Fiscal Year: 2013
    ..Tai Chi improves functional capacity (WOMAC function subscale, and chair-stand performance), muscle strength, knee joint proprioception, health related quality of life (SF36), and psychosocial functioning (mood, stress, self-efficacy ..
  12. Relationship of Hip Muscle Group Weakness to Deterioration of the OA Knee by MRI
    Leena Sharma; Fiscal Year: 2012
    ..Recent findings support that hip muscle forces may play an important role in knee joint protection in persons with osteoarthritic knees...
  13. Cartilage, Bone and Marrow Interactions in Knee OA
    Ravinder Reddy Regatte; Fiscal Year: 2013
    ..a more effective means of identifying individuals at higher risk for knee OA progression via quantitative knee joint assessment of cartilage, trabecular bone and bone marrow...
  14. A Joint-Coupled Controlled-Brake Orthosis System for Hybrid FES Gait Restoration
    Michael Goldfarb; Fiscal Year: 2013
    ..This limitation is addressed by the orthosis, which includes a mechanical biasing of the knee joint and unidirectionally couples knee flexion to hip flexion, and with this combination pro- vides the hip and knee ..
  15. Function and Behavior Phenotype of Inflammatory Arthritis in the Rat Knee and TMJ
    Kyle D Allen; Fiscal Year: 2010
    ..This proposal begins with the mentored phase where interleukin 1p (IL-lp) overexpression in the knee joint will be used as a rat model of unilateral inflammatory arthritis...
  16. Synovium-based articular cartilage tissue engineering
    Ernst B Hunziker; Fiscal Year: 2010
    ..e., from the shoulder joint, from the knee joint and from the metatarsal joint of bovine origin...
  17. Quantitative UTE MR Imaging: Sensitive Biomarkers for Osteoarthritis
    Jiang Du; Fiscal Year: 2013
    ..than the TEs of conventional sequences, and allow us to detect water signals from MR "invisible" tissues in the knee joint. In addition we have developed a spin-lock prepared UTE sequence to measure T1r, a T2-prepared UTE sequence to ..
  18. Dynamic Instability in Persons with Knee Osteoarthritis
    Leena Sharma; Fiscal Year: 2012
    ..This is a key, modifiable component of the knee joint environment that has received little attention, despite a potentially large role of dynamic instability in the ..
  19. Early NMES to Improve Quadriceps Muscle Function After Total Knee Arthroplasty
    Jennifer E Stevens-Lapsley; Fiscal Year: 2012
    ..for quadriceps reflex inhibition are not fully understood, spinal reflex activity from swelling or pain in the knee joint may alter afferent input from the injured joint and result in diminished efferent motor drive to the quadriceps ..
  20. Determination of pain phenotypes in older adults with knee osteoarthritis
    Jennifer E Stevens-Lapsley; Fiscal Year: 2013
    ..of pain in knee OA has grown dramatically in recent years-we now know that structural damage to the knee joint is only one of many possible contributions to the experience of knee pain in older adults...
  21. MCP-1/CCR2 Signaling in the Maintenance of OA Pathology and Associated Pain
    RACHEL ELIZABETH MILLER; Fiscal Year: 2013
    ..Aim 1b will compare the progression of pathology, cellular infiltration, and cytokine expression in the knee joint of WT and Ccr2 null mice after DMM...
  22. Biologically Enhanced Healing of Autograft ACL Reconstruction.
    Martha M Murray; Fiscal Year: 2012
    ..Aim 2 is to delineate the effects of the platelet hydrogel on knee joint laxity and the articular cartilage material properties after 12 weeks of healing...
  23. Quantitative MRI analysis method for longitudinal assessment of knee OA
    JEFFREY W DURYEA; Fiscal Year: 2012
    ..resonance imaging (MRI) offers direct three dimensional (3D) visualization of the articular cartilage in the knee joint. New high-field three-Tesla (3T) MRI scanners and specialized pulse sequences can provide images with excellent ..
  24. HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITIS
    STEVEN KINCAID; Fiscal Year: 1991
    ..active matrix degradation by proteases, will be created by transection of the cranial cruciate ligament of the knee joint. The cranial cruciate ligament of the left knee of 5 groups of 4 dogs will be transected...
  25. Rapid MRI Method of Assessing Joint Degeneration
    Walter F Block; Fiscal Year: 2012
    ..develop a high resolution imaging tool for rapid "whole organ" assessment and cartilage volume analysis of the knee joint for use in OA research studies...
  26. Open Knee(s): Virtual Biomechanical Representations of the Knee Joint
    Ahmet Erdemir; Fiscal Year: 2013
    ..Development of robust and reliable knee joint models is a daunting task...
  27. Designing a meniscal substitute through an integrated experimental computational
    Suzanne A Maher; Fiscal Year: 2013
    ..provided by applicant): The menisci are C-shaped fibrocartilage disks that occupy the periphery of the knee joint and serve a number of significant mechanical functions including load distribution across articular cartilage, ..
  28. Referral Patterns and Risk of Early Revision after Primary Total Joint Arthroplas
    STEPHEN L LYMAN; Fiscal Year: 2010
    ..Revision total joint arthroplasty (rTJA) for the hip or knee joint is a complex, costly procedure. Approximately 83,000 are performed annually in the US (2006 estimate)...
  29. Quadriceps inhibition after ACL injury: Neuromuscular and functional consequences
    RIANN MARIE PALMIERI-SMITH; Fiscal Year: 2012
    ..clinical interventions that can improve the neuromuscular and functional recovery of persons following traumatic knee joint injury and those with osteoarthritis...
  30. In vivo ACL Reconstruction Biomechanics
    Guoan Li; Fiscal Year: 2012
    ..The effect of combined meniscal tear on knee joint kinematics after ACL reconstruction will be analyzed quantitatively...
  31. Can Neuromuscular Training Alter Movement Patterns?
    Lynn Snyder-Mackler; Fiscal Year: 2013
    ..training, but recover much more slowly after surgery and continue to demonstrate aberrant movement patterns and knee joint loads...
  32. Powered Knee Prosthesis Incorporating Battery-Capacitor Hybrid
    BADAWI M DWEIK; Fiscal Year: 2012
    ..prosthetic knee requires fluctuating power requirements to fully emulate the mechanical behavior of the human knee joint. Currently, the power requirements are met primarily using a battery...
  33. A computer modeling tool for optimizing Meniscus Allograft Transplantation
    Xudong Zhang; Fiscal Year: 2012
    ..are quantitative in vivo data and mechanistic descriptions of how meniscus allograft transplantation affects the knee joint function and mechanics...
  34. Pain Mechanisms of Knee Joint Osteoarthritis
    HEE JEONG IM SAMPEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Patients suffering from persistent knee joint pain typically have cartilage degeneration with structural and morphological changes in synovium, meniscus and subchondral bone at the damage knee joint ..
  35. Patterned Microtexture for Improved Durability of Orthopedic Knee Implants
    RONALD L JACOBSEN; Fiscal Year: 2013
    ..1 project will verify the hypothesis that a surface so textured can generate full fluid lubrication at realistic knee joint sliding velocities to reduce friction and wear that eventually lead to implant failure...
  36. Sodium MRI for Assessment of Early OA.
    Ravinder Reddy Regatte; Fiscal Year: 2013
    ..Once developed, validated in human knee joint then the sodium methodology will be translated on to a clinically relevant 3T platform...
  37. Analysis of single-bundle versus double-bundle technique in ACL reconstruction
    Samuel K Van de Velde; Fiscal Year: 2010
    The anterior cruciate ligament (ACL) of the knee joint can be divided anatomically into an anteromedial and posterolateral bundle. Yet, most current ACL reconstruction techniques focus on replacing only the anteromedial bundle...
  38. Behavioral and Social Science Research on Understanding and Reducing Health Dispa
    Said A Ibrahim; Fiscal Year: 2013
    ..between AA patients and orthopaedic surgeons and on the likelihood of receiving a recommendation for knee joint replacement when clinically indicated...
  39. Motor Planning in Children with Cerebral Palsy
    MAX KURZ; Fiscal Year: 2013
    ..the quantitative relationship between formulation and execution of the motor plan and performance of the knee joint in TD children and children with CP...
  40. Differentiation of Central versus Peripheral Fatigue in Parkinson's Disease
    A Joseph Threlkeld; Fiscal Year: 2012
    ..b>Knee joint torque and electromyographic activities of the quadriceps and hamstrings will be measured during maximal ..
  41. MRI for Early Detection of Osteoarthritis
    Garry E Gold; Fiscal Year: 2013
    ..we aim to (1) develop more sensitive methods of 3D imaging for quantifying the morphology of the whole knee joint, including both cartilage and other important structures, (2) develop methods for quantitative 3D imaging of ..
  42. Adaptive High Intensity Electrical Stimulation for Post-Surgical Rehabilitation
    Eric Hartman; Fiscal Year: 2009
    ..system indicated for quadriceps strengthening during post-surgical knee immobilization in which the knee joint will be stabilized using an instrumented post-surgical knee brace and stimulation is delivered by a high output, ..
  43. HyCart - Biologic Cartilage Resurfacing with a Functional Osteochondral Implant
    JAMES POSER; Fiscal Year: 2013
    ..The goal of this proposal is to develop the osteochondral HyCart product to enable resurfacing of entire knee joint compartments and repair of defects up to 20cm2 in articular cartilage of the knee joint...
  44. Hormone Mediated Knee Joint Laxity and Neuromechanics
    SANDRA SHULTZ; Fiscal Year: 2009
    ..and cyclic increases in anterior knee laxity (CYCAKi.) on knee joint neuromechanics during functional activities...
  45. PEPTIDE RELEASE FROM PERIPHERAL TERMINALS OF AFFERENTS
    Tony Yaksh; Fiscal Year: 1991
    ..in small dorsal root ganglia, is transported peripherally, and is present in peripheral nerve terminals in knee joint and skin...
  46. Disparity in Joint Replacement: Pathway to Intervention
    Ibrahim Said; Fiscal Year: 2011
    ..next phase in a trajectory of research ultimately designed to eliminate racial disparities in the utilization of knee joint replacement - an effective treatment option for moderate to severe knee OA...
  47. Biologic scaffold prostheses to enhance meniscus repair
    JOE WEINBERG; Fiscal Year: 2009
    Abstract Menisci play critical roles in stabilization and load transmission in the knee joint. Meniscal damage or loss often results in progressive osteoarthritic degeneration of the articular cartilage and other joint tissues, leading ..
  48. Robotic Prosthesis for Biomimetic Locomotion in Transfemoral Amputees
    Michael Goldfarb; Fiscal Year: 2010
    ..walking upstairs and up slopes, running, and jumping, all of which require significant net positive power at the knee joint, ankle joint, or both...
  49. Medial Collapse Movement Impairments associated with Patellofemoral Pain
    GRETCHEN SALSICH; Fiscal Year: 2009
    ..and help guide future studies aimed at investigating relationships between lower extremity movement impairments, knee joint alignment, and patellar cartilage properties, as well as studies that test intervention and prevention ..
  50. A Novel Load Sensing Tibial Prosthesis Design
    DARRYL D LIMA; Fiscal Year: 2006
    ..changing joint contact position, intra- and extra-articular ligaments, number of muscles crossing the knee joint and the presence of the patellofemoral joint contribute to the difficulty in developing reliable models of the ..
  51. HUMAN RESPONSE AND LOWER EXTREMITY INJURY
    CLAYTON MOTE; Fiscal Year: 1991
    ..and to analyze the forces and moments between the boot and the ski, the rotations and translations across the knee joint, and the EMG from muscle groups...
  52. IN VIVO STRAIN MEASUREMENT OF RECONSTRUCTED AC LIGAMENT
    Robert Johnson; Fiscal Year: 1993
    ..with normal anterior cruciate ligaments, and demonstrate our ability to restore normal kinematics to the knee joint at the time of RACL implantation...
  53. Acoustic Measurement of Bubbles in Biological Media
    Georges Chahine; Fiscal Year: 2006
    ..g. tissue) and complex geometries (e.g. knee joint) will be developed, validated and integrated into the current system...
  54. PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TES
    John McGuire; Fiscal Year: 2001
    ..Twenty JRA children with bilateral knee joint involvement will be studied during six months while using nocturnal TES as an adjunct to a physical therapy home ..
  55. PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TES
    MICHELLE URBAN; Fiscal Year: 1999
    ..Twenty JRA children with bilateral knee joint involvement will be studied during six months while using nocturnal TES as an adjunct to a physical therapy home ..
  56. Gene Transfer of Growth Factors and Receptors as Therap*
    Ernest Terwilliger; Fiscal Year: 2002
    ..system to deliver gene sequences for two distinct chondrocyte growth factors, IGF-1 and FGF-2, directly into the knee joint in a rabbit model of articular cartilage injury as a direct test of this concept...
  57. Age-Related Differences in Cartilage OP-1
    Susan Chubinskaya; Fiscal Year: 2005
    ..a joint that rarely develops OA (ankle joint) compared to changes in a joint with the higher prevalence of OA (knee joint)...
  58. Enabling ACL Repair Using Proprietary Collagen Device
    Emma Wright; Fiscal Year: 2009
    ..Our goal is met when 80% <lameness of 3. Aim 2: Delineate the effects of the collagen-platelet composite on knee joint laxity (anteroposterior/axial) after 12 weeks of healing...
  59. BONE AND KNEE LOADING
    Hiroki Yokota; Fiscal Year: 2005
    ..In this project, we propose to investigate a novel mechanical loading model- knee joint loading - to stimulate bone formation and to strengthen mechanical properties of femur and a femoral neck...
  60. LOGIC CONTROLLED ELECTROMECHANICAL FREE KNEE ORTHOSIS
    Kenton Kaufman; Fiscal Year: 2000
    ..Currently, these types of patients are usually fitted with either a conventional KAFO which has a knee joint equipped with a mechanical manual lock, or a free-knee orthosis equipped with an eccentric knee joint...
  61. FIBROCARTILAGINOUS KNEE JOINT MENISCI: BIOLOGY & REPAIR
    Richard Webber; Fiscal Year: 1991
    The experiments are designed to study further the biology and repair capabilities of the fibrocartilaginous knee joint meniscus and provide important data regarding fundamental aspects of the cell biology of fibrocartilage as a tissue...
  62. HAPTOTACTIC REPAIR OF THE MENISCUS
    CAHIR MCDEVITT; Fiscal Year: 2002
    ..body of literature documenting the critical role the menisci play in the general biomedical functioning of the knee joint and the specific protection of articular cartilage...
  63. EVALUATOR TRAINING MANIKIN FOR SPASTICITY AND STRENGTH
    DAVID ENGSBERG; Fiscal Year: 2003
    ..The purpose of this project is to develop and test a manikin knee joint for training clinicians to uniformly assess knee spasticity and strength. Aim 1...
  64. CARTILAGE FROM ANIMAL MODELS OF OA & JOINT DISUSE
    VAN MOW; Fiscal Year: 1990
    The project goals are: 1) to determine biomechanical properties of knee joint cartilage subjected to joint disuse (JD), disuse followed by ad libitum recovery (JD+R), disuse followed by excessive exercise (JD+E) and from the Pond-Nuki ..
  65. EXPERIMENTAL MODEL TO EVALUATE ACL GRAFT HEALING
    Braden Fleming; Fiscal Year: 1999
    ..be possible to embark on a long-term investigation that evaluates the interaction between initial graft tension, knee joint kinematics, and the structural/material properties of the ACL graft...