Genomes and Genes
Summary: The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.
Publications384 found, 100 shown here
- Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritisBeatrix Bartok
Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, La Jolla, CA 92093, USA
Immunol Rev 233:233-55. 2010..New agents that target FLS could potentially complement the current therapies without major deleterious effect on adaptive immune responses...
- Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell sourceYusuke Sakaguchi
Tokyo Medical and Dental University, Japan
Arthritis Rheum 52:2521-9. 2005..To compare the properties of human mesenchymal stem cells (MSCs) isolated from bone marrow, synovium, periosteum, skeletal muscle, and adipose tissue...
- Evidence that cytokines play a role in rheumatoid arthritisFionula M Brennan
Kennedy Institute of Rheumatology, Imperial College London, London, UK
J Clin Invest 118:3537-45. 2008..In this Review, we discuss the biologic contribution and therapeutic potential of the major cytokine families to RA pathology, focusing on molecules contained within the TNF-alpha, IL-1, IL-6, IL-23, and IL-2 families...
- T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokinesF Fossiez
Schering Plough, Laboratory for Immunological Research, Dardilly, France
J Exp Med 183:2593-603. 1996..These observations suggest that hIL-17 may constitute (a) an early initiator of the T cell-dependent inflammmatory reaction; and (b) an element of the cytokine network that bridges the immune system to hematopoiesis...
- The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblastsChih Hsin Tang
China Medical University and China Medical University Hospital, Taichung, Taiwan
Arthritis Rheum 62:3615-24. 2010..This study was undertaken to investigate the intracellular signaling pathways involved in CCL5-induced interleukin-6 (IL-6) production in human synovial fibroblasts...
- The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammationHulda Sigridur Hreggvidsdottir
Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Karolinska Institutet, S 171 76 Stockholm, Sweden
J Leukoc Biol 86:655-62. 2009..HMGB1 thus acts broadly with many but not all immunostimulatory molecules to amplify their activity in a synergistic manner...
- Synovial tissue inflammation in early and late osteoarthritisM J Benito
Department of Rheumatology, Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
Ann Rheum Dis 64:1263-7. 2005..To compare selected immunohistological features of inflammation in synovial tissue from patients with early and late osteoarthritis (OA)...
- Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologiesD Kontoyiannis
Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
Immunity 10:387-98. 1999..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies...
- Expression of microRNA-146 in rheumatoid arthritis synovial tissueTomoyuki Nakasa
National Research Institute for Child Health and Development, Tokyo, Japan
Arthritis Rheum 58:1284-92. 2008..The objective of this study was to identify the expression pattern of microRNA-146 (miR-146) in synovial tissue from patients with rheumatoid arthritis (RA)...
- Macrophages in rheumatoid arthritisR W Kinne
Experimental Rheumatology Unit, Friedrich Schiller University, Jena, Germany
Arthritis Res 2:189-202. 2000The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA)...
- Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritisPeter L E M van Lent
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Arthritis Rheum 64:1466-76. 2012..To investigate whether alarmins S100A8 and S100A9 are involved in mediating cartilage destruction during murine and human osteoarthritis (OA)...
- Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscleHideya Yoshimura
Section of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Cell Tissue Res 327:449-62. 2007..In particular, synovium-derived cells had the greatest potential for both proliferation and chondrogenesis, indicating their usefulness for cartilage study in a rat model...
- Synovitis score: discrimination between chronic low-grade and high-grade synovitisV Krenn
Institute for Pathology, Trier, and Department for Rheumatology, Charite University Hospital, Berlin, Germany
Histopathology 49:358-64. 2006To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non-rheumatic joint diseases.
- Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritisB T Wipke
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 167:1601-8. 2001..These studies have identified a critical role for neutrophils in initiating and maintaining inflammatory processes in the joint...
- The role of reactive oxygen species in homeostasis and degradation of cartilageY E Henrotin
Bone and Cartilage Research Unit, Institute of Pathology, Level 5, CHU Sart Tilman, Liege, Belgium
Osteoarthritis Cartilage 11:747-55. 2003..ROS production has been found to increase in joint diseases, such as osteoarthritis and rheumatoid arthritis, but their role in joint diseases initiation and progression remains questionable...
- Mast cells express IL-17A in rheumatoid arthritis synoviumAxel J Hueber
Division of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
J Immunol 184:3336-40. 2010....
- MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritisYuji Nakamachi
Department of Clinical Laboratory, Kobe University Hospital, and Kobe University Graduate School of Medicine, Kobe, Japan
Arthritis Rheum 60:1294-304. 2009..To elucidate the role of microRNA (miRNA) in the pathogenesis of rheumatoid arthritis (RA), we analyzed synoviocytes from RA patients for their miRNA expression...
- Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritisTroy Noordenbos
Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
Arthritis Rheum 64:99-109. 2012..Recent observations have indicated a marked synovial mast cell infiltration in psoriatic SpA. We therefore undertook the present study to investigate the potential contribution of mast cells to synovial inflammation in SpA...
- Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritisPaul J Egan
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Arthritis Rheum 58:3720-9. 2008..To examine the generation of proinflammatory Th17 cells at the site of tissue inflammation and in draining lymph nodes using an interleukin-17 (IL-17)-dependent model of acute inflammatory arthritis...
- Adiponectin-mediated changes in effector cells involved in the pathophysiology of rheumatoid arthritisKlaus W Frommer
Justus Liebig University Giessen and Kerckhoff Klinik, Bad Nauheim, Germany
Arthritis Rheum 62:2886-99. 2010....
- Rheumatoid arthritis progression mediated by activated synovial fibroblastsElena Neumann
Dept of Internal Medicine and Rheumatology, Justus Liebig University Giesen, Kerckhoff Klinik, Benekestr 2 8, D 61231 Bad Nauheim, Germany
Trends Mol Med 16:458-68. 2010..Here, we review new findings regarding RASF activation and their altered behavior that contribute to matrix destruction and inflammation as well as their potential to spread RA...
- Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defectHideyuki Koga
Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Arthritis Res Ther 10:R84. 2008..We have developed a novel transplantation method with synovial mesenchymal stem cells (MSCs) to adhere to the cartilage defect...
- Global metabolic profiling of human osteoarthritic synoviumS B Adams
Department of Orthopaedic Surgery, Duke University Medical Center, Duke University, Durham, NC, USA
Osteoarthritis Cartilage 20:64-7. 2012..Metabolites specific to collagen metabolism, branched-chain amino acid metabolism, energy metabolism and tryptophan metabolism were amongst the most significant compounds, suggesting an altered metabolic state with disease progression...
- Interleukin-17, a regulator of angiogenic factor release by synovial fibroblastsM C Honorati
Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
Osteoarthritis Cartilage 14:345-52. 2006....
- Correlation of power Doppler sonography with vascularity of the synovial tissue of the knee joint in patients with osteoarthritis and rheumatoid arthritisM Walther
University of Wuerzburg, Germany
Arthritis Rheum 44:331-8. 2001..hypertrophy of the knee joint by verifying and comparing the PDS findings with histopathologic findings of synovial membrane vascularity...
- Galectin 3 and its binding protein in rheumatoid arthritisShiro Ohshima
Center of Experimental Rheumatology, University Hospital, Zurich, Switzerland
Arthritis Rheum 48:2788-95. 2003....
- CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytesPing Zhu
Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, PR China
Arthritis Res Ther 8:R44. 2006..These findings suggest that CD147 may be one of the important factors in progressive joint destruction of RA and that CD147 may be a potential therapeutic target in RA treatment...
- Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritisJ J Haringman
Division of Clinical Immunology and Rheumatology F4 218, Department of Internal Medicine, Academic Medical Centre University of Amsterdam, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
Ann Rheum Dis 65:294-300. 2006..Chemokine receptors and chemokines have a crucial role in leucocyte recruitment into inflamed tissue...
- Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytesA Marsano
Departments of Surgery and Research, University Hospital Basel, Basel, Switzerland
Osteoarthritis Cartilage 15:48-58. 2007..To identify an appropriate cell source for the generation of meniscus substitutes, among those which would be available by arthroscopy of injured knee joints...
- IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 inductionShiva Shahrara
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Immunol 184:4479-87. 2010....
- IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritisM Chabaud
INSERM U403, , and Departments of Immunology and Rheumatology, , Lyon, France
Arthritis Res 3:168-77. 2001..In conclusion, the contribution of IL-17 derived from synovium and bone marrow T cells to joint destruction suggests the control of IL-17 for the treatment of RA...
- Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patientsX Ayral
Service de Rhumatologie B, Hopital Cochin, AP HP, Universite Rene Descartes, Paris, France
Osteoarthritis Cartilage 13:361-7. 2005..To evaluate the prevalence of synovitis in painful medial tibiofemoral knee osteoarthritis (OA) and to evaluate correlation between synovitis and the structural severity and progression of tibiofemoral cartilage damage...
- Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A productionJ P van Hamburg
Department of Rheumatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Arthritis Rheum 63:73-83. 2011..The aim of this study was to identify and characterize the functional role of Th17 cells in early RA...
- Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritisA E Koch
Department of Medicine, Northwestern University Medical School, Chicago, Illinois
J Clin Invest 94:1012-8. 1994..05). These results, which are the first demonstration of ENA-78 in a human disease state, suggest that ENA-78 may play an important role in the recruitment of PMNs in the milieu of the inflamed joint of RA patients...
- Expression of IL-19 and its receptors in RA: potential role for synovial hyperplasia formationN Sakurai
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, 3 39 15 Showa, Maebashi, Gunma 371 8511, Japan
Rheumatology (Oxford) 47:815-20. 2008..IL-19 is a novel cytokine of the IL-10 family. In this study, we sought to examine whether IL-19 plays a role in the pathogenesis of RA...
- Angiogenesis in the synovium and at the osteochondral junction in osteoarthritisD A Walsh
Academic Rheumatology, University of Nottingham Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
Osteoarthritis Cartilage 15:743-51. 2007..We investigated whether indices of osteochondral and synovial angiogenesis display different relationships with synovitis, disease severity and chondrocalcinosis in patients with OA...
- Multipotent mesenchymal stem cells from adult human synovial membraneC De Bari
Katholieke Universiteit Leuven, Belgium
Arthritis Rheum 44:1928-42. 2001OBJECTIVE: To characterize mesenchymal stem cells (MSCs) from human synovial membrane (SM)...
- Synovial fibroblasts spread rheumatoid arthritis to unaffected jointsStephanie Lefèvre
Department of Internal Medicine and Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim, Germany
Nat Med 15:1414-20. 2009..These findings support the hypothesis that the characteristic clinical phenomenon of destructive arthritis spreading between joints is mediated, at least in part, by the transmigration of activated RASFs...
- Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synoviumFrances Humby
William Harvey Research Institute, Barts and the London School of Medicine, Charterhouse Square, London, United Kingdom
PLoS Med 6:e1. 2009....
- Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritisX Chang
Laboratory for Rheumatic Diseases, SNP Research Center, Institute of Physical and Chemical Research RIKEN, 1 7 22 Suehiro, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Rheumatology (Oxford) 44:40-50. 2005..Here, we localized the expression of PADI4 and the citrullinated protein product in synovial RA tissue...
- Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodelingAntonio Manzo
William Harvey Research Institute, Barts and the London School of Medicine, London, UK
Immunol Rev 233:267-85. 2010..We finally provide a brief overview of the most recent studies addressing the clinical relevance of synovial lymphoid tissue analysis as a diagnostic and prognostic tool as well as its response to current biological therapies...
- Synovial fluid CD146 (MUC18), a marker for synovial membrane angiogenesis in rheumatoid arthritisM Neidhart
Center for Experimental Rheumatology, University Hospital, Zurich, Switzerland
Arthritis Rheum 42:622-30. 1999..We measured the synovial fluid levels of soluble CD146 in various human joint diseases, including rheumatoid arthritis (RA). In addition, we studied the distribution of CD146 in normal and RA synovial tissues...
- Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune diseaseP L Klarenbeek
Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
Ann Rheum Dis 71:1088-93. 2012....
- High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patientsM C Honorati
Laboratorio Immunologia e Genetica, Istituto Codivilla Putti IOR, Via Di Barbiano 1 10, 40136 Bologna, Italy
Rheumatology (Oxford) 40:522-7. 2001..To evaluate the presence of interleukin-17 (IL-17) and the expression of IL-17 receptor (IL-17R) in joint tissues from subjects with different arthritides...
- Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritisJinpiao Lin
Shanghai Institute of Immunology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
J Immunol 188:5776-84. 2012..Our study also suggests that targeting of Cyr61 may represent a novel strategy in RA treatment...
- Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor-alphaC Chenevier-Gobeaux
Laboratoire de Biochimie A, Hopital Cochin, Assistance Publique Hopitaux de Paris AP HP, 27 rue du Faubourg Saint Jacques, 75679, Paris Cedex 14, France
Inflamm Res 55:483-90. 2006..to evaluate the rheumatoid synovial cell capacity to produce superoxide anion in response to interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha), and to study the NADPH oxidase involvement in this production...
- Imaging of synovitis in osteoarthritis: current status and outlookDaichi Hayashi
Department of Radiology, Boston University School of Medicine, Boston, MA, USA
Semin Arthritis Rheum 41:116-30. 2011..Computed tomography and nuclear medicine including positron emission tomography are also briefly discussed...
- Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytesMi Kyoung Ha
Graduate School of East West Medical Science, Kyung Hee University, Korea
Biol Pharm Bull 34:1432-7. 2011..Overall, these findings suggest that emodin inhibits proinflammatory cytokines and VEGF productions, and HDAC1 activity in hypoxic RA synoviocytes...
- Toll-like receptor 2 induced angiogenesis and invasion is mediated through the Tie2 signalling pathway in rheumatoid arthritisTajvur Saber
Department of Rheumatology, Dublin Academic Medical Centre and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
PLoS ONE 6:e23540. 2011..This study investigates the effect of TLR2 on angiogenesis, EC adhesion and invasion using microvascular endothelial cells and RA whole tissue synovial explants ex-vivo...
- Synoviocyte infection with adeno-associated virus (AAV) is neutralized by human synovial fluid from arthritis patients and depends on AAV serotypeM C Boissier
INSERM, ERI 18, F 93017 Bobigny, France
Hum Gene Ther 18:525-35. 2007..Thus, serotype 5 seems to demonstrate the best infection efficiency:immunogenicity ratio for local use in articular diseases. These data may be useful for tailoring intraarticular AAV-mediated gene therapy to individual patients...
- The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysisF Pessler
The Children s Hospital of Philadelphia, Division of Rheumatology, Philadelphia, USA
Ann Rheum Dis 67:1184-7. 2008..To quantify inflammatory changes in synovial membranes from orthopaedic "non-inflammatory" arthropathies (Orth. A)...
- Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cellsPeter L E M van Lent
Department of Rheumatology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 48:360-9. 2003....
- Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid jointA E Koch
Northwestern University Medical School and Veterans Administration Chicago Health Care System, Lakeside Division, Illinois, USA
Arthritis Rheum 44:31-40. 2001..It is possible that efforts aimed at down-regulating these chemokines offer a novel targeted therapy for the treatment of RA...
- The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritisErika H Noss
Division of Rheumatology, Allergy, and Immunology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Immunol Rev 223:252-70. 2008..Greater understanding of how FLS are activated and how they interact with other cells in the RA synovium may provide insights that allow development of novel agents for RA therapy...
- Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytesK Varani
Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
Br J Pharmacol 160:101-15. 2010..We evaluated mRNA, the protein levels, the functional role of adenosine receptors and their pharmacological modulation in human synoviocytes...
- Overexpression of transcription factor Ets-1 in rheumatoid arthritis synovial membrane: regulation of expression and activation by interleukin-1 and tumor necrosis factor alphaK Redlich
University of Vienna, Austria
Arthritis Rheum 44:266-74. 2001....
- Up-regulation of prostaglandin E receptor EP2 and EP4 subtypes in rat synovial tissues with adjuvant arthritisY Kurihara
Division of Rheumatology, Department of Internal Medicine, Kitasato University School of Medicine, Kitasato, Kanagawa, Japan
Clin Exp Immunol 123:323-30. 2001..Our results suggest that prostaglandin E2 regulates the functions of synovial macrophages and fibroblasts through EP2 and EP4, which are induced by inflammatory stimuli in rats with adjuvant arthritis...
- Modulation of STAT-3 in rheumatoid synovial T cells suppresses Th17 differentiation and increases the proportion of Treg cellsJi Hyeon Ju
Seoul St Mary s Hospital, Republic of Korea
Arthritis Rheum 64:3543-52. 2012..To investigate the impact of STAT-3-mediated regulation on Th17 differentiation in patients with rheumatoid arthritis (RA)...
- Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblastsKiichiro Ando
Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
Oncogene 22:7796-803. 2003..Thus, RSF may have re-acquired the primordial phenotype, accounting for the hyperproliferation and aggressive invasiveness, exhibiting tumor-like phenotype...
- Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbitsTakashi Miyamoto
Section of Orthopaedic Surgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Arthritis Res Ther 12:R206. 2010..Here, we examined the effect of intradiscal transplantation of synovial MSCs after aspiration of nucleus pulposus in rabbits...
- Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathwayChih Hsin Tang
Department of Pharmacology, College of Medicine, China Medical University, Taichung, Taiwan
J Immunol 179:5483-92. 2007..Our results suggest that adiponectin increased IL-6 production in synovial fibroblasts via the AdipoR1 receptor/AMPK/p38/IKKalphabeta and NF-kappaB signaling pathway...
- Pathophysiology of rheumatoid arthritisFaye A H Cooles
Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, UK
Curr Opin Rheumatol 23:233-40. 2011..To provide a summary of recent advances in the pathophysiology of rheumatoid arthritis...
- NF-AT5 is a critical regulator of inflammatory arthritisHyung Ju Yoon
Catholic University of Korea, Seoul, Republic of Korea
Arthritis Rheum 63:1843-52. 2011..To investigate the role of NF-AT5, an osmoprotective transcription factor, in synovial hyperplasia and angiogenesis in patients with rheumatoid arthritis (RA)...
- Expression of notch homologues in the synovium of rheumatoid arthritis and osteoarthritis patientsH Ishii
Rheumatology, Immunology and Genetics Program, Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan
Rheumatol Int 21:10-4. 2001..These results indicate that the expression pattern of Notch among synovium from OA and RA patients differed from that of normal subjects...
- An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouseTatiana Aparecida Pimentel
Post Graduation in Morphology, Federal University of Sao Paulo UNIFESP, Paulista School of Medicine EPM, Rua Botucatu, Sao Paulo, Brazil
Lab Invest 91:33-42. 2011..These results provide evidence for local alterations whereby mast cells contribute to the initiation of inflammatory arthritis and may be targeted in intervention strategies...
- Kinetic analysis of synovial signalling and gene expression in animal models of arthritisAkihisa Fukushima
Division of Rheumatology, Allergy and Immunology, University of California, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0656, USA
Ann Rheum Dis 69:918-23. 2010..Animal models of arthritis are frequently used to evaluate novel therapeutic agents. However, their ability to predict responses in humans is variable...
- Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblastsValerie Gossye
Ghent University, Ghent, Belgium
Arthritis Rheum 60:3241-50. 2009....
- Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinases in rheumatoid arthritisTetsuya Tomita
Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
Arthritis Rheum 46:373-8. 2002..To investigate the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) at sites of joint destruction in rheumatoid arthritis (RA) and to correlate it with the production of matrix metalloproteinases (MMPs)...
- The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damageMax Brenner
Laboratory of Experimental Rheumatology, R S Boas Center for Genomics and Human Genetics, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
Arthritis Rheum 52:322-32. 2005....
- Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosionErik Lubberts
University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 50:650-9. 2004..This T cell cytokine is implicated in the initiation phase of arthritis. However, the role of IL-17 during the effector phase of arthritis has still not been identified; this was the objective of the present study...
- Human rheumatoid synoviocytes express functional P2X7 receptorsFrancesca Caporali
Department of Clinical Medicine and Immunological Sciences, Section of Clinical Immunology, University of Siena, Policlinico Le Scotte, Viale Bracci, Siena, Italy
J Mol Med (Berl) 86:937-49. 2008..In conclusion, among the different P2 receptors expressed on human RA type B synoviocytes, the P2X7 receptor may modulate IL-6 release but not inducing changes in cell membrane permeability...
- IL-17 induces monocyte migration in rheumatoid arthritisShiva Shahrara
Department of Medicine, Feinberg School of Medicine, Northwestern University Chicago, IL 60611, USA
J Immunol 182:3884-91. 2009..These observations suggest that IL-17 may be important in recruiting monocytes into the joints of patients with RA, supporting IL-17 as a therapeutic target in RA...
- Clinical significance of serum levels of vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in patients with rheumatoid arthritisDaitaro Kurosaka
Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8, Nishishinbashi, Minato ku, Tokyo, Japan
J Rheumatol 37:1121-8. 2010..To evaluate the clinical significance of serum levels of vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), and angiopoietin-2 (Ang-2) in patients with rheumatoid arthritis (RA)...
- Cytokines regulate fibroblast-like synovial cell differentiation to adipocyte-like cellsS Yamasaki
First Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
Rheumatology (Oxford) 43:448-52. 2004..The aim of the present study was to determine the role of cytokines in the regulation of FLS differentiation to adipocyte-like cells...
- Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis: comparison with IL1 beta and tumour necrosis factor alphaS M Dai
Department of Bioregulation, Institute of Medical Science, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8512, Japan
Ann Rheum Dis 63:1379-86. 2004..To determine whether IL18 has any indirect effects on osteoclastogenesis mediated by T cells in RA synovium, and compare its effects with those of IL1 beta and TNF alpha...
- Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblastsKwok Man Tong
Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan
Cell Signal 20:1478-88. 2008..These results suggest that leptin increased IL-8 production in synovial fibroblast via the OBRl/JAK2/STAT3 pathway, as well as the activation of IRS1/PI3K/Akt/NF-kappaB-dependent pathway and the subsequent recruitment of p300...
- Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritisTakashi Hamada
Kagoshima University, Kagoshima, Japan
Arthritis Rheum 58:2675-85. 2008..This study was thus undertaken to investigate the hypothesis that extracellular HMGB-1 may be a coupling factor between hypoxia and inflammation in arthritis...
- Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritisJoanna Stanczyk
Center of Experimental Rheumatology, University Hospital Zurich, and Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Arthritis Rheum 58:1001-9. 2008..In this study we investigated the expression, regulation, and function of miR-155 and miR-146a in rheumatoid arthritis (RA) synovial fibroblasts (RASFs) and RA synovial tissue...
- Intra-articular Injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defectMasafumi Horie
Section of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
Stem Cells 27:878-87. 2009..Synovium-MSCs injected into the massive meniscectomized knee adhered to the lesion, differentiated into meniscal cells directly, and promoted meniscal regeneration without mobilization to distant organs...
- Citrullination is an inflammation-dependent processD Makrygiannakis
Department of Medicine, Rheumatology Unit, CMM, L8 04, Karolinska University Hospital, Solna, S 17176 Stockholm, Sweden
Ann Rheum Dis 65:1219-22. 2006..To study the presence of citrullinated proteins in inflammatory conditions and in clinically non-affected tissues of controls...
- Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytesJ Morales Ducret
UCSD Medical Center 92103
J Immunol 149:1424-31. 1992..Therefore, both CS-1 and VCAM-1 participate in VLA-4-mediated adherence to resting FLS in vitro, and VCAM-1 is responsible for the increase in Jurkat binding mediated by cytokines...
- Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synoviocytesArnaud Hot
Department of Clinical Immunology and Rheumatology, University of Lyon, Edouard Herriot Hospital, France
Ann Rheum Dis 70:727-32. 2011..Finally, they enhance metalloprotease secretion leading to cartilage damage. These properties support the combined inhibition of IL-17A and -F to control RA inflammation and joint destruction...
- Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammationRowan S Hardy
Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham Medical School, Birmingham, UK
Arthritis Res Ther 8:R108. 2006....
- Fractalkine: a novel angiogenic chemokine in rheumatoid arthritisM V Volin
Department of Medicine, Northwestern University, Chicago, Illinois, USA
Am J Pathol 159:1521-30. 2001..05). These results establish a new function for fkn as an angiogenic mediator and suggest that it may mediate angiogenesis in RA...
- Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritisCheol Park
Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
Int J Mol Med 20:365-72. 2007..These results show that curcumin might help identify a new therapeutic pathway against hyperplasia of the synovial fibroblasts in RA...
- Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transforming growth factor beta1 induce the formation of different types of cartilaginous tissueNahoko Shintani
ITI Research Institute for Dental and Skeletal Biology, University of Bern, Bern, Switzerland
Arthritis Rheum 56:1869-79. 2007....
- The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowthDavid K Rhee
Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
J Clin Invest 115:622-31. 2005..We conclude that lubricin has multiple functions in articulating joints and tendons that include the protection of surfaces and the control of synovial cell growth...
- Synovial tissue hypoxia and inflammation in vivoC T Ng
Dublin Academic Medical Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
Ann Rheum Dis 69:1389-95. 2010....
- Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritisNathalie Busso
Laboratory of Rheumatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
J Immunol 168:875-82. 2002..In conclusion, leptin contributes to the mechanisms of joint inflammation in Ag-induced arthritis by regulating both humoral and cell-mediated immune responses...
- Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathyDominique Baeten
Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
Arthritis Res Ther 7:R359-69. 2005..These data support a prominent role for innate immune cells in SpA synovitis and warrant further evaluation of synovial histopathology as a surrogate marker in early-phase therapeutic trials in SpA...
- Skeletal muscle repair by adult human mesenchymal stem cells from synovial membraneCosimo De Bari
Laboratory for Skeletal Development and Joint Disorders, Dept of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
J Cell Biol 160:909-18. 2003We have demonstrated previously that adult human synovial membrane-derived mesenchymal stem cells (hSM-MSCs) have myogenic potential in vitro (De Bari, C., F. Dell'Accio, P. Tylzanowski, and F.P. Luyten. 2001. Arthritis Rheum...
- Regulation by PGE2 of the production of interleukin-6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblastsHideo Inoue
Research Laboratory, Minophagen Pharmaceutical Co, 2 2 3 Komatsubara, Zama shi, Kanagawa 228 0002, Japan
Br J Pharmacol 136:287-95. 2002..6. These results suggest that endogenous PGE(2) regulates the production of IL-6, M-CSF, and VEGF by IL-1beta-stimulated human synovial fibroblasts through the activation of EP(2) and EP(4) receptors with increase in cyclic AMP...
- The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimeraH Matsuno
Department of Orthopedic Surgery, Toyama Medical and Pharmaceutical University, Toyama, UK
Rheumatology (Oxford) 41:329-37. 2002....
- Joint diseases and matrix metalloproteinases: a role for MMP-13Hironari Takaishi
Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
Curr Pharm Biotechnol 9:47-54. 2008..This review describes a body of research that supports the development of novel selective MMP-13 inhibitors with the hope of developing these compounds in clinical trials for the treatment of arthritis...
- Predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult onset Still's diseaseD Y Chen
Department of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, No 160, Section 3 Taichung Kang Road, Taichung City, 40705 Taiwan
Ann Rheum Dis 63:1300-6. 2004..To determine the type 1 T helper (Th1)/type 2 T helper (Th2) balance in the peripheral blood (PB) and pathological tissues of patients with active untreated adult onset Still's disease (AOSD)...
- Interleukin 27 attenuates collagen-induced arthritisW Niedbala
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
Ann Rheum Dis 67:1474-9. 2008....
- PI3Kgamma regulates cartilage damage in chronic inflammatory arthritisSilvia Hayer
Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
FASEB J 23:4288-98. 2009....
- Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membraneE B Hunziker
M E Müller Institute for Biomechanics, University of Bern, Switzerland
J Bone Joint Surg Am 78:721-33. 1996..Histological studies revealed a continuous layer of mesenchymal cells extending from the synovial membrane across the superficial tangential zone of normal articular cartilage into the defect, indicating that the ..
- Regional analysis of p53 mutations in rheumatoid arthritis synoviumYuji Yamanishi
Division of Rheumatology, Allergy, and Immunology, University of California at San Diego School of Medicine, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 99:10025-30. 2002..A relatively low percentage of cells containing p53 mutations can potentially affect neighboring cells and enhance inflammation through the elaboration of proinflammatory cytokines...
- Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytesSaloua Zrioual
Department of Immunology and Rheumatology and Hospices Civils de Lyon bioMerieux Mixed Research Unit, Hospital Edouard Herriot, Lyon, France
J Immunol 182:3112-20. 2009..IL-17A and IL-17F are both expressed in RA synovium. In the presence of TNF-alpha, they induced a similar expression pattern in RA synoviocytes. Accordingly, IL-17F appears as a target in Th17-mediated diseases such as RA...
- Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trialClarissa E Vergunst
Academic Medical Center, and University of Amsterdam, Amsterdam, The Netherlands
Arthritis Rheum 58:1931-9. 2008..Blocking CCR2 prevents CCL2-mediated chemotaxis in vitro and modulates arthritis in animal models of RA. In this study we examined the effects of CCR2 blockade on synovial inflammation in RA...
- The Toll-like receptor pathway in Meniscal Injury and OsteoarthritisCARLA ROSE SCANZELLO; Fiscal Year: 2013..Perhaps the least understood pathologic change that occurs in the OA joint is the inflammation within the synovial membrane (SM)...
- Dual-Energy Cone-Beam Tomographic Imaging and Analysis for Rheumatoid ArthritisJeffrey H Siewerdsen; Fiscal Year: 2013..findings following the current gold standard in image-based assessment [the RA MRI score (RAMRIS)] - namely, synovial membrane volume (SMv), bone marrow edema volume (BMEv), and erosion volume (Ev) - as well as novel metrics of fully ..
- Mandibular Cartilage Regeneration In Situ by Endogenous Stem Cell RecruitmentWendy S Vanden Berg-Foels; Fiscal Year: 2013..Local MSC sources for synovial joints include the synovial membrane (sMSC) and the bone marrow (bMSC)...
- Synovium-based articular cartilage tissue engineeringErnst B Hunziker; Fiscal Year: 2010..by introducing an adult stem cell population directly into the defect space by the autotransplantation of synovial membrane flaps, the difficulties can be overcome and the repair of large defect areas and volumes induced...
- OPTICAL TOMOGRAPHY FOR THE DIAGNOSIS OF JOINT DISEASESANDREAS HIELSCHER; Fiscal Year: 2007..Based on our studies we now believe that three main processes (effusion, erosion, and hypertrophy of the synovial membrane (synovitis)) that accompany RA can be distinguished by optical tomography (OT)...
- GENETIC PREDICTORS OF RESPONSE TO TREATMENT IN EARLY RAS Bridges; Fiscal Year: 2001Rheumatoid arthritis (RA) is characterized by inflammation in the synovial membrane, often leading to joint destruction. HLA DRB1 alleles containing the shared epitope (SE) influence RA susceptibility and severity...
- Transcriptome-based biomarkers in Human OsteoarthritisSteven Abramson; Fiscal Year: 2004..The disease process affects the entire joint structure, including cartilage, synovial membrane, subchondral bone, which are active sites of growth factor, cytokine, protease and inflammatory mediator ..
- IKKi expression and regulation in rheumatoid arthritisGary Firestein; Fiscal Year: 2005..We propose to test the hypothesis that IKKi is an important signal transduction pathway that regulates inflammation in chronic arthritis and is a novel target for development of anti-rheumatic agents. ..
- SYNOVIAL DYSFUNCTION DUE TO P53 ABNORMALITIES IN RAGary Firestein; Fiscal Year: 2006..abstract_text> ..
- REGULATION OF PERIPHERAL INFLAMMATION BY THE CNSGary Firestein; Fiscal Year: 2002..These studies will provide a basis for understanding the central nervous system-immune system connection as well as explore novel therapeutic targets. ..
- Chemokine receptor antagonists in inflammatory diseaseShiva Shahrara; Fiscal Year: 2007..Achieving these goals may give us valuable information in regard to molecular inflammatory mechanisms involved in atherosclerosis and RA. ..
- TH-1 BIAS IN RHEUMATOID ARTHRITISLaurie Davis; Fiscal Year: 2003..It is anticipated that the information obtained should provide important new insights into the regulatory influences on the differentiation of CD4+ memory effector cells in man. ..
- FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERSMARY CORR; Fiscal Year: 2004..The results of these studies will both contribute to, and will utilize, the resources of the OA biomarker consortium. ..
- Delivery of Therapeutic Genes to Osteoarthritic JointsChristopher Evans; Fiscal Year: 2002....
- Signaling Molecules and Long Bone FormationMaurizio Pacifici; Fiscal Year: 2005..The results will provide much needed information on the regulation of long bone formation, and will have relevance to questions of skeletal growth, fracture repair and congenital conditions of cartilage and bone. ..
- Lanthanides as Novel Anti-Arthritic AgentsChristopher Evans; Fiscal Year: 2004..A successful outcome to these studies will have identified the basis for a potential new, very inexpensive anti-rheumatic agent whose mode of action differs from that of existing drugs. ..
- AAOS/NIH Mulit-Year Research Symposia for 2005-2009Christopher Evans; Fiscal Year: 2005....
- REGULATION OF CHONDROCYTE PROLIFERATIONMaurizio Pacifici; Fiscal Year: 2002....
- Novel Nanostructured Calcium Phosphate for Gene Delivery to BoneChristopher Evans; Fiscal Year: 2005..2. To evaluate the ability of nCaP-vector constructs to enhance osteogenic responses in vivo. ..
- Role of the 4A11 antigen in rheumatoid arthritisMohammad Amin; Fiscal Year: 2008..Targeting this antigen may provide a potential therapeutic to RA. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Mechanisms of Synovial Joint FormationMaurizio Pacifici; Fiscal Year: 2009..The results will be invaluable in conceiving novel, directed and specific therapies to repair and restore malfunctioning joints common to aging individuals and otherwise affected patients. ..
- EFFECT OF COMP MUTATION ON MUSCULOSKELETAL DEVELOPMENTPaul Di Cesare; Fiscal Year: 2002..Identifying the functions, synthesis, interactions, tissue distribution and expression of COMP is critical to understanding its influence on growth during endochondral ossification and articular cartilage structure and function. ..
- Accelerated arthritis in E and P selectin deficient miceJeffrey Ruth; Fiscal Year: 2007..While common dogma suggests IL-1beta regulates selectins, this study proposes the novel hypothesis that in vivo E- and P-selectins regulate IL-1beta production and CIA development. [unreadable] [unreadable] [unreadable]..
- Regulation of Vascular Calcification in DiabetesXUENING CHEN; Fiscal Year: 2007....
- Tissue engineered osteochondral patella resurfacingJames Cook; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Innate immunity and experimental Lyme arthritisCharles Brown; Fiscal Year: 2007..As such these studies; may have important implications not only for Lyme disease, but for other inflammatory diseases as well. ..
- THE ROLE OF p204 IN OSTEOGENESISChuanju Liu; Fiscal Year: 2007..A greater understanding of the process of how bone is generated can lead to new therapies which can help stem or reverse the course of these diseases. [unreadable] [unreadable] [unreadable]..
- Mucin expression in rheumatoid arthritisMICHAEL VOLIN; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- The Interaction of Mechanical Load and Inflammation in Tendon-Bone HealingScott A Rodeo; Fiscal Year: 2010..The results of our studies will allow a scientific basis for the design of post- operative rehabilitation prescription. ..
- Eicosanoid regulation of experimental Lyme arthritisCharles R Brown; Fiscal Year: 2010..This information will further our understanding of how inflammation is regulated and allow the design of more effective anti-inflammatory treatments. ..
- Interferon Regulation in Systemic LupusLionel B Ivashkiv; Fiscal Year: 2010..These experiments will yield insight into the molecular pathogenesis of SLE and identify novel therapeutic approaches to manipulatecytokine activity in SLE at the level of signal transduction. ..
- CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASEAlan Hudson; Fiscal Year: 2002..Such new information may well provide important new insights for development of novel therapeutic modalities to prevent or ameliorate late-onset AD. ..
- Epigenetic Regulation of MMP-13MARY GOLDRING; Fiscal Year: 2008..The proposed studies will advance considerably our understanding about the importance of DNA methylation in the pathology of OA. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- The role BH3 and multi BH domain genes in regulating monocyte survival and functiHarris Perlman; Fiscal Year: 2008..Further our goal is to characterize mice lacking Bim or it signaling partners only in monocytes and macrophages. [unreadable] [unreadable] [unreadable]..
- Reiter's syndrome mechanism of chlamydial pathogenesisAlan Hudson; Fiscal Year: 2008....
- Innate Immunity in gouty InflammationRU BRYAN; Fiscal Year: 2008..Completion of this work will help further understanding the mechanisms of acute gouty inflammation, how to control gouty arthritis and potentially other forms of crystal-induced inflammation. [unreadable] [unreadable] [unreadable]..
- Determination of OA Pathology by Biomarker DatingVirginia Kraus; Fiscal Year: 2007..We refer to the technique of quantifying the D-aspartate content of cartilage macromolecules as "biomarker dating". ..
- Immune Tolerance after Severe Immunosuppression and Stem Cell Rescue for JIAYukiko Kimura; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Activation of Cutaneous Mechanoreceptors by Shear StressPeter Grigg; Fiscal Year: 2007..In this proposal we propose to dynamically manipulate shear stress, and measure shear strain, in an attempt to determine whether activation of afferent neurons is caused by shear or normal components of stress or strain. ..
- STRATEGIES TO PREDICT OSTEOARTHRITIS PROGRESSIONVirginia Kraus; Fiscal Year: 2006..The results of these studies could aid in the refinement of subject selection for clinical trials and those most in need of prevention strategies. ..
- Role of fractalkine signaling in rheumatoid arthritisJames Woods; Fiscal Year: 2004..These experiments should provide extensive new insights about the mechanism of fkn signaling through CX3CR1 and its relationship to cellular function. ..
- CD1 IMMUNE RESPONSES AND VACCINES IN ANIMAL MODELS OF TBMichael Brenner; Fiscal Year: 2004..Together, these studies will move forward our understanding of the basic biology of CD1 antigen presentation during microbial infection in vivo with applications of this emerging biology to vaccine development. ..
- Physical Regulation of Skeletal Repair WorkshopRoy Aaron; Fiscal Year: 2003..Finally, how repairing skeletal tissues organize physical information to augment the repair process, and what translational opportunities exist, will be considered. ..
- Induction of Apoptosis in Synovial FibroblastsHaidi Zhang; Fiscal Year: 2003Rheumatoid arthritis is characterized by hyperplasia of synovial membrane and bone destruction...
- IL-1 and IL-1ra Stimulation of S aureus ReplicationSIVADASAN KANANGAT; Fiscal Year: 2003..A better understanding of how bacteria such as S. aureus use IL-1 family of cytokines to replicate and defeat the host defense is highly relevant to the study of septic arthritis. ..
- T CELL RECEPTOR GAMMA/DELTAMichael Brenner; Fiscal Year: 2002..Studies that define ligand specificities of gamma/delta T-cells are essential to understanding the biological role of this ubiquitous but still enigmatic class of lymphocytes. ..
- METALLOPROTEINASES IN AGING AND OSTEOARTHRITISVirginia Kraus; Fiscal Year: 2002..They propose that successful completion of this work will serve as a basis for future studies of drug intervention for OA, and characterization and interaction of other pathogenic molecules in OA. ..
- Annotation of the Mycoplasma alligatoris genomeDaniel Brown; Fiscal Year: 2002..The ease of PCR-based cloning and the accessibility of bioinformatics software make this an ideal project to engage undergraduate students in innovative biomedical research. ..
- EVALULATION OF CARTILAGE GROWN FROM RIB PERICHONDRIUMRichard Coutts; Fiscal Year: 2001..The goal is to develop an implant that will consistently and predictably produce repairs of full-thickness articular cartilage defects that will function as well as normal cartilage. ..
- CHONDROPROTECTION BY A NOVEL RETINOID AND TRITERPENOIDMatthew Vincenti; Fiscal Year: 2004..This work will examine cellular/molecular events and whole animal models to characterize the chondroprotective potential of a novel steroid and a novel retinoid for the treatment of arthritis. ..
- BIOLOGICAL EFFECTS OF BASIC CALCIUM PHOSPHATE CRYSTALSHerman Cheung; Fiscal Year: 2004..Hypothesis 5: There are specific cis elements in the promotor of Tissue Inhibitor of Metalloproteinase (TIMP)-2 that regulate crystal inhibition of TIMP- 2 expression. ..
- Fas Ligand Gene Transfer Apoptosis Synovial FibroblastsHaidi Zhang; Fiscal Year: 2004DESCRIPTION (provided by the applicant): Rheumatoid arthritis (RA) is characterized by hyperplasia of synovial membrane and bone destruction...
- CD80 binding peptides as therapeutic agents in arthritisMythily Srinivasan; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- IL-8 in chondrocalcinosisRU BRYAN; Fiscal Year: 2005..The completion of this study has the potential to provide a foundation for novel chemokine and signal transduction-based therapeutic strategies for treatment of chondrocalcinosis in OA and aging. ..
- KCNRG gene as candidate tumor suppressor for CLL and MMAnna Baranova; Fiscal Year: 2005..Common gene changes revealed by activation of KCNRG will be confirmed in Real-Time PCR experiments. ..
- REGULATION OF MATRIX GENE EXPRESSION IN CHONDROCYTESMARY GOLDRING; Fiscal Year: 2001....
- ROLE OF INTEGRIN ALPHA E BETA 7 IN IMMUNE RESPONSESMichael Brenner; Fiscal Year: 2005..abstract_text> ..
- EXPRESSION OF MATRIX METALLOPROTEINASE AND P53Yubo Sun; Fiscal Year: 2004..Once the molecular mechanism addressed in this proposal is clearly defined, it may be possible to exploit the information gained for the development of an effective strategy for RA treatment. ..
- COORDINATE REGULATION OF APOPTOSIS AND CELL CYCLE IN RAHarris Perlman; Fiscal Year: 2004..This approach could lead to the development of a new therapeutic strategy for gene therapy in patients with rheumatoid arthritis. ..
- THE FUNCTION OF T-BET IN T HELPER CELL DEVELOPMENTStanford Peng; Fiscal Year: 2003..abstract_text> ..
- GTPase Activating Proteins in Aging and OsteoarthritisLisa Fortier; Fiscal Year: 2007..We anticipate that these findings will facilitate identification of target molecules for development of therapeutics modalities for OA. [unreadable] [unreadable] [unreadable]..
- Estrogenic Regulation of Inflammation Related to TMJDPhillip Kramer; Fiscal Year: 2006..The function of estrogen receptors ER alpha and/or ER beta will be directly addressed pharmacologically (e.g., antiestrogen) and through mutation studies of the Fc gamma RIIIA promoter. ..
- Estrogenic LXR Alpha Response /Cholesterol HomeostasisPhillip Kramer; Fiscal Year: 2003..abstract_text> ..