synovial membrane

Summary

Summary: The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.

Top Publications

  1. pmc Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis
    Beatrix Bartok
    Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, La Jolla, CA 92093, USA
    Immunol Rev 233:233-55. 2010
  2. ncbi Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source
    Yusuke Sakaguchi
    Tokyo Medical and Dental University, Japan
    Arthritis Rheum 52:2521-9. 2005
  3. pmc Evidence that cytokines play a role in rheumatoid arthritis
    Fionula M Brennan
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    J Clin Invest 118:3537-45. 2008
  4. pmc T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
    F Fossiez
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Exp Med 183:2593-603. 1996
  5. ncbi The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts
    Chih Hsin Tang
    China Medical University and China Medical University Hospital, Taichung, Taiwan
    Arthritis Rheum 62:3615-24. 2010
  6. ncbi The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation
    Hulda Sigridur Hreggvidsdottir
    Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Leukoc Biol 86:655-62. 2009
  7. pmc Synovial tissue inflammation in early and late osteoarthritis
    M J Benito
    Department of Rheumatology, Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
    Ann Rheum Dis 64:1263-7. 2005
  8. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
  9. pmc Expression of microRNA-146 in rheumatoid arthritis synovial tissue
    Tomoyuki Nakasa
    National Research Institute for Child Health and Development, Tokyo, Japan
    Arthritis Rheum 58:1284-92. 2008
  10. pmc Macrophages in rheumatoid arthritis
    R W Kinne
    Experimental Rheumatology Unit, Friedrich Schiller University, Jena, Germany
    Arthritis Res 2:189-202. 2000

Detail Information

Publications384 found, 100 shown here

  1. pmc Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis
    Beatrix Bartok
    Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, La Jolla, CA 92093, USA
    Immunol Rev 233:233-55. 2010
    ..New agents that target FLS could potentially complement the current therapies without major deleterious effect on adaptive immune responses...
  2. ncbi Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source
    Yusuke Sakaguchi
    Tokyo Medical and Dental University, Japan
    Arthritis Rheum 52:2521-9. 2005
    ..To compare the properties of human mesenchymal stem cells (MSCs) isolated from bone marrow, synovium, periosteum, skeletal muscle, and adipose tissue...
  3. pmc Evidence that cytokines play a role in rheumatoid arthritis
    Fionula M Brennan
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    J Clin Invest 118:3537-45. 2008
    ..In this Review, we discuss the biologic contribution and therapeutic potential of the major cytokine families to RA pathology, focusing on molecules contained within the TNF-alpha, IL-1, IL-6, IL-23, and IL-2 families...
  4. pmc T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
    F Fossiez
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Exp Med 183:2593-603. 1996
    ..These observations suggest that hIL-17 may constitute (a) an early initiator of the T cell-dependent inflammmatory reaction; and (b) an element of the cytokine network that bridges the immune system to hematopoiesis...
  5. ncbi The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts
    Chih Hsin Tang
    China Medical University and China Medical University Hospital, Taichung, Taiwan
    Arthritis Rheum 62:3615-24. 2010
    ..This study was undertaken to investigate the intracellular signaling pathways involved in CCL5-induced interleukin-6 (IL-6) production in human synovial fibroblasts...
  6. ncbi The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation
    Hulda Sigridur Hreggvidsdottir
    Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Leukoc Biol 86:655-62. 2009
    ..HMGB1 thus acts broadly with many but not all immunostimulatory molecules to amplify their activity in a synergistic manner...
  7. pmc Synovial tissue inflammation in early and late osteoarthritis
    M J Benito
    Department of Rheumatology, Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
    Ann Rheum Dis 64:1263-7. 2005
    ..To compare selected immunohistological features of inflammation in synovial tissue from patients with early and late osteoarthritis (OA)...
  8. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
    ..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies...
  9. pmc Expression of microRNA-146 in rheumatoid arthritis synovial tissue
    Tomoyuki Nakasa
    National Research Institute for Child Health and Development, Tokyo, Japan
    Arthritis Rheum 58:1284-92. 2008
    ..The objective of this study was to identify the expression pattern of microRNA-146 (miR-146) in synovial tissue from patients with rheumatoid arthritis (RA)...
  10. pmc Macrophages in rheumatoid arthritis
    R W Kinne
    Experimental Rheumatology Unit, Friedrich Schiller University, Jena, Germany
    Arthritis Res 2:189-202. 2000
    The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA)...
  11. ncbi Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis
    Peter L E M van Lent
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:1466-76. 2012
    ..To investigate whether alarmins S100A8 and S100A9 are involved in mediating cartilage destruction during murine and human osteoarthritis (OA)...
  12. ncbi Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle
    Hideya Yoshimura
    Section of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cell Tissue Res 327:449-62. 2007
    ..In particular, synovium-derived cells had the greatest potential for both proliferation and chondrogenesis, indicating their usefulness for cartilage study in a rat model...
  13. ncbi Synovitis score: discrimination between chronic low-grade and high-grade synovitis
    V Krenn
    Institute for Pathology, Trier, and Department for Rheumatology, Charite University Hospital, Berlin, Germany
    Histopathology 49:358-64. 2006
    To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non-rheumatic joint diseases.
  14. ncbi Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis
    B T Wipke
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 167:1601-8. 2001
    ..These studies have identified a critical role for neutrophils in initiating and maintaining inflammatory processes in the joint...
  15. ncbi The role of reactive oxygen species in homeostasis and degradation of cartilage
    Y E Henrotin
    Bone and Cartilage Research Unit, Institute of Pathology, Level 5, CHU Sart Tilman, Liege, Belgium
    Osteoarthritis Cartilage 11:747-55. 2003
    ..ROS production has been found to increase in joint diseases, such as osteoarthritis and rheumatoid arthritis, but their role in joint diseases initiation and progression remains questionable...
  16. ncbi Mast cells express IL-17A in rheumatoid arthritis synovium
    Axel J Hueber
    Division of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 184:3336-40. 2010
    ....
  17. ncbi MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    Yuji Nakamachi
    Department of Clinical Laboratory, Kobe University Hospital, and Kobe University Graduate School of Medicine, Kobe, Japan
    Arthritis Rheum 60:1294-304. 2009
    ..To elucidate the role of microRNA (miRNA) in the pathogenesis of rheumatoid arthritis (RA), we analyzed synoviocytes from RA patients for their miRNA expression...
  18. ncbi Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis
    Troy Noordenbos
    Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 64:99-109. 2012
    ..Recent observations have indicated a marked synovial mast cell infiltration in psoriatic SpA. We therefore undertook the present study to investigate the potential contribution of mast cells to synovial inflammation in SpA...
  19. ncbi Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis
    Paul J Egan
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Arthritis Rheum 58:3720-9. 2008
    ..To examine the generation of proinflammatory Th17 cells at the site of tissue inflammation and in draining lymph nodes using an interleukin-17 (IL-17)-dependent model of acute inflammatory arthritis...
  20. ncbi Adiponectin-mediated changes in effector cells involved in the pathophysiology of rheumatoid arthritis
    Klaus W Frommer
    Justus Liebig University Giessen and Kerckhoff Klinik, Bad Nauheim, Germany
    Arthritis Rheum 62:2886-99. 2010
    ....
  21. ncbi Rheumatoid arthritis progression mediated by activated synovial fibroblasts
    Elena Neumann
    Dept of Internal Medicine and Rheumatology, Justus Liebig University Giesen, Kerckhoff Klinik, Benekestr 2 8, D 61231 Bad Nauheim, Germany
    Trends Mol Med 16:458-68. 2010
    ..Here, we review new findings regarding RASF activation and their altered behavior that contribute to matrix destruction and inflammation as well as their potential to spread RA...
  22. pmc Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect
    Hideyuki Koga
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Res Ther 10:R84. 2008
    ..We have developed a novel transplantation method with synovial mesenchymal stem cells (MSCs) to adhere to the cartilage defect...
  23. pmc Global metabolic profiling of human osteoarthritic synovium
    S B Adams
    Department of Orthopaedic Surgery, Duke University Medical Center, Duke University, Durham, NC, USA
    Osteoarthritis Cartilage 20:64-7. 2012
    ..Metabolites specific to collagen metabolism, branched-chain amino acid metabolism, energy metabolism and tryptophan metabolism were amongst the most significant compounds, suggesting an altered metabolic state with disease progression...
  24. ncbi Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts
    M C Honorati
    Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Osteoarthritis Cartilage 14:345-52. 2006
    ....
  25. ncbi Correlation of power Doppler sonography with vascularity of the synovial tissue of the knee joint in patients with osteoarthritis and rheumatoid arthritis
    M Walther
    University of Wuerzburg, Germany
    Arthritis Rheum 44:331-8. 2001
    ..hypertrophy of the knee joint by verifying and comparing the PDS findings with histopathologic findings of synovial membrane vascularity...
  26. ncbi Galectin 3 and its binding protein in rheumatoid arthritis
    Shiro Ohshima
    Center of Experimental Rheumatology, University Hospital, Zurich, Switzerland
    Arthritis Rheum 48:2788-95. 2003
    ....
  27. pmc CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes
    Ping Zhu
    Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, PR China
    Arthritis Res Ther 8:R44. 2006
    ..These findings suggest that CD147 may be one of the important factors in progressive joint destruction of RA and that CD147 may be a potential therapeutic target in RA treatment...
  28. pmc Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis
    J J Haringman
    Division of Clinical Immunology and Rheumatology F4 218, Department of Internal Medicine, Academic Medical Centre University of Amsterdam, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Ann Rheum Dis 65:294-300. 2006
    ..Chemokine receptors and chemokines have a crucial role in leucocyte recruitment into inflamed tissue...
  29. ncbi Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes
    A Marsano
    Departments of Surgery and Research, University Hospital Basel, Basel, Switzerland
    Osteoarthritis Cartilage 15:48-58. 2007
    ..To identify an appropriate cell source for the generation of meniscus substitutes, among those which would be available by arthroscopy of injured knee joints...
  30. pmc IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 induction
    Shiva Shahrara
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 184:4479-87. 2010
    ....
  31. pmc IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
    M Chabaud
    INSERM U403, , and Departments of Immunology and Rheumatology, , Lyon, France
    Arthritis Res 3:168-77. 2001
    ..In conclusion, the contribution of IL-17 derived from synovium and bone marrow T cells to joint destruction suggests the control of IL-17 for the treatment of RA...
  32. ncbi Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients
    X Ayral
    Service de Rhumatologie B, Hopital Cochin, AP HP, Universite Rene Descartes, Paris, France
    Osteoarthritis Cartilage 13:361-7. 2005
    ..To evaluate the prevalence of synovitis in painful medial tibiofemoral knee osteoarthritis (OA) and to evaluate correlation between synovitis and the structural severity and progression of tibiofemoral cartilage damage...
  33. ncbi Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production
    J P van Hamburg
    Department of Rheumatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Arthritis Rheum 63:73-83. 2011
    ..The aim of this study was to identify and characterize the functional role of Th17 cells in early RA...
  34. pmc Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis
    A E Koch
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois
    J Clin Invest 94:1012-8. 1994
    ..05). These results, which are the first demonstration of ENA-78 in a human disease state, suggest that ENA-78 may play an important role in the recruitment of PMNs in the milieu of the inflamed joint of RA patients...
  35. ncbi Expression of IL-19 and its receptors in RA: potential role for synovial hyperplasia formation
    N Sakurai
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, 3 39 15 Showa, Maebashi, Gunma 371 8511, Japan
    Rheumatology (Oxford) 47:815-20. 2008
    ..IL-19 is a novel cytokine of the IL-10 family. In this study, we sought to examine whether IL-19 plays a role in the pathogenesis of RA...
  36. ncbi Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis
    D A Walsh
    Academic Rheumatology, University of Nottingham Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Osteoarthritis Cartilage 15:743-51. 2007
    ..We investigated whether indices of osteochondral and synovial angiogenesis display different relationships with synovitis, disease severity and chondrocalcinosis in patients with OA...
  37. ncbi Multipotent mesenchymal stem cells from adult human synovial membrane
    C De Bari
    Katholieke Universiteit Leuven, Belgium
    Arthritis Rheum 44:1928-42. 2001
    OBJECTIVE: To characterize mesenchymal stem cells (MSCs) from human synovial membrane (SM)...
  38. pmc Synovial fibroblasts spread rheumatoid arthritis to unaffected joints
    Stephanie Lefèvre
    Department of Internal Medicine and Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim, Germany
    Nat Med 15:1414-20. 2009
    ..These findings support the hypothesis that the characteristic clinical phenomenon of destructive arthritis spreading between joints is mediated, at least in part, by the transmigration of activated RASFs...
  39. pmc Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium
    Frances Humby
    William Harvey Research Institute, Barts and the London School of Medicine, Charterhouse Square, London, United Kingdom
    PLoS Med 6:e1. 2009
    ....
  40. ncbi Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis
    X Chang
    Laboratory for Rheumatic Diseases, SNP Research Center, Institute of Physical and Chemical Research RIKEN, 1 7 22 Suehiro, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Rheumatology (Oxford) 44:40-50. 2005
    ..Here, we localized the expression of PADI4 and the citrullinated protein product in synovial RA tissue...
  41. ncbi Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling
    Antonio Manzo
    William Harvey Research Institute, Barts and the London School of Medicine, London, UK
    Immunol Rev 233:267-85. 2010
    ..We finally provide a brief overview of the most recent studies addressing the clinical relevance of synovial lymphoid tissue analysis as a diagnostic and prognostic tool as well as its response to current biological therapies...
  42. ncbi Synovial fluid CD146 (MUC18), a marker for synovial membrane angiogenesis in rheumatoid arthritis
    M Neidhart
    Center for Experimental Rheumatology, University Hospital, Zurich, Switzerland
    Arthritis Rheum 42:622-30. 1999
    ..We measured the synovial fluid levels of soluble CD146 in various human joint diseases, including rheumatoid arthritis (RA). In addition, we studied the distribution of CD146 in normal and RA synovial tissues...
  43. ncbi Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease
    P L Klarenbeek
    Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 71:1088-93. 2012
    ....
  44. ncbi High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients
    M C Honorati
    Laboratorio Immunologia e Genetica, Istituto Codivilla Putti IOR, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Rheumatology (Oxford) 40:522-7. 2001
    ..To evaluate the presence of interleukin-17 (IL-17) and the expression of IL-17 receptor (IL-17R) in joint tissues from subjects with different arthritides...
  45. ncbi Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis
    Jinpiao Lin
    Shanghai Institute of Immunology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Immunol 188:5776-84. 2012
    ..Our study also suggests that targeting of Cyr61 may represent a novel strategy in RA treatment...
  46. ncbi Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor-alpha
    C Chenevier-Gobeaux
    Laboratoire de Biochimie A, Hopital Cochin, Assistance Publique Hopitaux de Paris AP HP, 27 rue du Faubourg Saint Jacques, 75679, Paris Cedex 14, France
    Inflamm Res 55:483-90. 2006
    ..to evaluate the rheumatoid synovial cell capacity to produce superoxide anion in response to interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha), and to study the NADPH oxidase involvement in this production...
  47. ncbi Imaging of synovitis in osteoarthritis: current status and outlook
    Daichi Hayashi
    Department of Radiology, Boston University School of Medicine, Boston, MA, USA
    Semin Arthritis Rheum 41:116-30. 2011
    ..Computed tomography and nuclear medicine including positron emission tomography are also briefly discussed...
  48. ncbi Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes
    Mi Kyoung Ha
    Graduate School of East West Medical Science, Kyung Hee University, Korea
    Biol Pharm Bull 34:1432-7. 2011
    ..Overall, these findings suggest that emodin inhibits proinflammatory cytokines and VEGF productions, and HDAC1 activity in hypoxic RA synoviocytes...
  49. pmc Toll-like receptor 2 induced angiogenesis and invasion is mediated through the Tie2 signalling pathway in rheumatoid arthritis
    Tajvur Saber
    Department of Rheumatology, Dublin Academic Medical Centre and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    PLoS ONE 6:e23540. 2011
    ..This study investigates the effect of TLR2 on angiogenesis, EC adhesion and invasion using microvascular endothelial cells and RA whole tissue synovial explants ex-vivo...
  50. ncbi Synoviocyte infection with adeno-associated virus (AAV) is neutralized by human synovial fluid from arthritis patients and depends on AAV serotype
    M C Boissier
    INSERM, ERI 18, F 93017 Bobigny, France
    Hum Gene Ther 18:525-35. 2007
    ..Thus, serotype 5 seems to demonstrate the best infection efficiency:immunogenicity ratio for local use in articular diseases. These data may be useful for tailoring intraarticular AAV-mediated gene therapy to individual patients...
  51. ncbi The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis
    F Pessler
    The Children s Hospital of Philadelphia, Division of Rheumatology, Philadelphia, USA
    Ann Rheum Dis 67:1184-7. 2008
    ..To quantify inflammatory changes in synovial membranes from orthopaedic "non-inflammatory" arthropathies (Orth. A)...
  52. ncbi Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cells
    Peter L E M van Lent
    Department of Rheumatology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:360-9. 2003
    ....
  53. ncbi Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid joint
    A E Koch
    Northwestern University Medical School and Veterans Administration Chicago Health Care System, Lakeside Division, Illinois, USA
    Arthritis Rheum 44:31-40. 2001
    ..It is possible that efforts aimed at down-regulating these chemokines offer a novel targeted therapy for the treatment of RA...
  54. ncbi The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis
    Erika H Noss
    Division of Rheumatology, Allergy, and Immunology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 223:252-70. 2008
    ..Greater understanding of how FLS are activated and how they interact with other cells in the RA synovium may provide insights that allow development of novel agents for RA therapy...
  55. pmc Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes
    K Varani
    Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Br J Pharmacol 160:101-15. 2010
    ..We evaluated mRNA, the protein levels, the functional role of adenosine receptors and their pharmacological modulation in human synoviocytes...
  56. ncbi Overexpression of transcription factor Ets-1 in rheumatoid arthritis synovial membrane: regulation of expression and activation by interleukin-1 and tumor necrosis factor alpha
    K Redlich
    University of Vienna, Austria
    Arthritis Rheum 44:266-74. 2001
    ....
  57. pmc Up-regulation of prostaglandin E receptor EP2 and EP4 subtypes in rat synovial tissues with adjuvant arthritis
    Y Kurihara
    Division of Rheumatology, Department of Internal Medicine, Kitasato University School of Medicine, Kitasato, Kanagawa, Japan
    Clin Exp Immunol 123:323-30. 2001
    ..Our results suggest that prostaglandin E2 regulates the functions of synovial macrophages and fibroblasts through EP2 and EP4, which are induced by inflammatory stimuli in rats with adjuvant arthritis...
  58. ncbi Modulation of STAT-3 in rheumatoid synovial T cells suppresses Th17 differentiation and increases the proportion of Treg cells
    Ji Hyeon Ju
    Seoul St Mary s Hospital, Republic of Korea
    Arthritis Rheum 64:3543-52. 2012
    ..To investigate the impact of STAT-3-mediated regulation on Th17 differentiation in patients with rheumatoid arthritis (RA)...
  59. ncbi Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblasts
    Kiichiro Ando
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Oncogene 22:7796-803. 2003
    ..Thus, RSF may have re-acquired the primordial phenotype, accounting for the hyperproliferation and aggressive invasiveness, exhibiting tumor-like phenotype...
  60. pmc Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits
    Takashi Miyamoto
    Section of Orthopaedic Surgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arthritis Res Ther 12:R206. 2010
    ..Here, we examined the effect of intradiscal transplantation of synovial MSCs after aspiration of nucleus pulposus in rabbits...
  61. ncbi Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, China Medical University, Taichung, Taiwan
    J Immunol 179:5483-92. 2007
    ..Our results suggest that adiponectin increased IL-6 production in synovial fibroblasts via the AdipoR1 receptor/AMPK/p38/IKKalphabeta and NF-kappaB signaling pathway...
  62. ncbi Pathophysiology of rheumatoid arthritis
    Faye A H Cooles
    Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, UK
    Curr Opin Rheumatol 23:233-40. 2011
    ..To provide a summary of recent advances in the pathophysiology of rheumatoid arthritis...
  63. pmc NF-AT5 is a critical regulator of inflammatory arthritis
    Hyung Ju Yoon
    Catholic University of Korea, Seoul, Republic of Korea
    Arthritis Rheum 63:1843-52. 2011
    ..To investigate the role of NF-AT5, an osmoprotective transcription factor, in synovial hyperplasia and angiogenesis in patients with rheumatoid arthritis (RA)...
  64. ncbi Expression of notch homologues in the synovium of rheumatoid arthritis and osteoarthritis patients
    H Ishii
    Rheumatology, Immunology and Genetics Program, Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan
    Rheumatol Int 21:10-4. 2001
    ..These results indicate that the expression pattern of Notch among synovium from OA and RA patients differed from that of normal subjects...
  65. pmc An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse
    Tatiana Aparecida Pimentel
    Post Graduation in Morphology, Federal University of Sao Paulo UNIFESP, Paulista School of Medicine EPM, Rua Botucatu, Sao Paulo, Brazil
    Lab Invest 91:33-42. 2011
    ..These results provide evidence for local alterations whereby mast cells contribute to the initiation of inflammatory arthritis and may be targeted in intervention strategies...
  66. pmc Kinetic analysis of synovial signalling and gene expression in animal models of arthritis
    Akihisa Fukushima
    Division of Rheumatology, Allergy and Immunology, University of California, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0656, USA
    Ann Rheum Dis 69:918-23. 2010
    ..Animal models of arthritis are frequently used to evaluate novel therapeutic agents. However, their ability to predict responses in humans is variable...
  67. ncbi Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts
    Valerie Gossye
    Ghent University, Ghent, Belgium
    Arthritis Rheum 60:3241-50. 2009
    ....
  68. ncbi Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinases in rheumatoid arthritis
    Tetsuya Tomita
    Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Arthritis Rheum 46:373-8. 2002
    ..To investigate the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) at sites of joint destruction in rheumatoid arthritis (RA) and to correlate it with the production of matrix metalloproteinases (MMPs)...
  69. ncbi The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage
    Max Brenner
    Laboratory of Experimental Rheumatology, R S Boas Center for Genomics and Human Genetics, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Arthritis Rheum 52:322-32. 2005
    ....
  70. ncbi Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    Erik Lubberts
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:650-9. 2004
    ..This T cell cytokine is implicated in the initiation phase of arthritis. However, the role of IL-17 during the effector phase of arthritis has still not been identified; this was the objective of the present study...
  71. ncbi Human rheumatoid synoviocytes express functional P2X7 receptors
    Francesca Caporali
    Department of Clinical Medicine and Immunological Sciences, Section of Clinical Immunology, University of Siena, Policlinico Le Scotte, Viale Bracci, Siena, Italy
    J Mol Med (Berl) 86:937-49. 2008
    ..In conclusion, among the different P2 receptors expressed on human RA type B synoviocytes, the P2X7 receptor may modulate IL-6 release but not inducing changes in cell membrane permeability...
  72. pmc IL-17 induces monocyte migration in rheumatoid arthritis
    Shiva Shahrara
    Department of Medicine, Feinberg School of Medicine, Northwestern University Chicago, IL 60611, USA
    J Immunol 182:3884-91. 2009
    ..These observations suggest that IL-17 may be important in recruiting monocytes into the joints of patients with RA, supporting IL-17 as a therapeutic target in RA...
  73. ncbi Clinical significance of serum levels of vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in patients with rheumatoid arthritis
    Daitaro Kurosaka
    Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8, Nishishinbashi, Minato ku, Tokyo, Japan
    J Rheumatol 37:1121-8. 2010
    ..To evaluate the clinical significance of serum levels of vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), and angiopoietin-2 (Ang-2) in patients with rheumatoid arthritis (RA)...
  74. ncbi Cytokines regulate fibroblast-like synovial cell differentiation to adipocyte-like cells
    S Yamasaki
    First Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Rheumatology (Oxford) 43:448-52. 2004
    ..The aim of the present study was to determine the role of cytokines in the regulation of FLS differentiation to adipocyte-like cells...
  75. pmc Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis: comparison with IL1 beta and tumour necrosis factor alpha
    S M Dai
    Department of Bioregulation, Institute of Medical Science, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8512, Japan
    Ann Rheum Dis 63:1379-86. 2004
    ..To determine whether IL18 has any indirect effects on osteoclastogenesis mediated by T cells in RA synovium, and compare its effects with those of IL1 beta and TNF alpha...
  76. ncbi Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts
    Kwok Man Tong
    Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan
    Cell Signal 20:1478-88. 2008
    ..These results suggest that leptin increased IL-8 production in synovial fibroblast via the OBRl/JAK2/STAT3 pathway, as well as the activation of IRS1/PI3K/Akt/NF-kappaB-dependent pathway and the subsequent recruitment of p300...
  77. ncbi Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis
    Takashi Hamada
    Kagoshima University, Kagoshima, Japan
    Arthritis Rheum 58:2675-85. 2008
    ..This study was thus undertaken to investigate the hypothesis that extracellular HMGB-1 may be a coupling factor between hypoxia and inflammation in arthritis...
  78. ncbi Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
    Joanna Stanczyk
    Center of Experimental Rheumatology, University Hospital Zurich, and Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Arthritis Rheum 58:1001-9. 2008
    ..In this study we investigated the expression, regulation, and function of miR-155 and miR-146a in rheumatoid arthritis (RA) synovial fibroblasts (RASFs) and RA synovial tissue...
  79. ncbi Intra-articular Injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect
    Masafumi Horie
    Section of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    Stem Cells 27:878-87. 2009
    ..Synovium-MSCs injected into the massive meniscectomized knee adhered to the lesion, differentiated into meniscal cells directly, and promoted meniscal regeneration without mobilization to distant organs...
  80. pmc Citrullination is an inflammation-dependent process
    D Makrygiannakis
    Department of Medicine, Rheumatology Unit, CMM, L8 04, Karolinska University Hospital, Solna, S 17176 Stockholm, Sweden
    Ann Rheum Dis 65:1219-22. 2006
    ..To study the presence of citrullinated proteins in inflammatory conditions and in clinically non-affected tissues of controls...
  81. ncbi Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes
    J Morales Ducret
    UCSD Medical Center 92103
    J Immunol 149:1424-31. 1992
    ..Therefore, both CS-1 and VCAM-1 participate in VLA-4-mediated adherence to resting FLS in vitro, and VCAM-1 is responsible for the increase in Jurkat binding mediated by cytokines...
  82. ncbi Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synoviocytes
    Arnaud Hot
    Department of Clinical Immunology and Rheumatology, University of Lyon, Edouard Herriot Hospital, France
    Ann Rheum Dis 70:727-32. 2011
    ..Finally, they enhance metalloprotease secretion leading to cartilage damage. These properties support the combined inhibition of IL-17A and -F to control RA inflammation and joint destruction...
  83. pmc Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation
    Rowan S Hardy
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham Medical School, Birmingham, UK
    Arthritis Res Ther 8:R108. 2006
    ....
  84. pmc Fractalkine: a novel angiogenic chemokine in rheumatoid arthritis
    M V Volin
    Department of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Pathol 159:1521-30. 2001
    ..05). These results establish a new function for fkn as an angiogenic mediator and suggest that it may mediate angiogenesis in RA...
  85. ncbi Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis
    Cheol Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Int J Mol Med 20:365-72. 2007
    ..These results show that curcumin might help identify a new therapeutic pathway against hyperplasia of the synovial fibroblasts in RA...
  86. ncbi Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transforming growth factor beta1 induce the formation of different types of cartilaginous tissue
    Nahoko Shintani
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Bern, Switzerland
    Arthritis Rheum 56:1869-79. 2007
    ....
  87. pmc The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
    David K Rhee
    Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Invest 115:622-31. 2005
    ..We conclude that lubricin has multiple functions in articulating joints and tendons that include the protection of surfaces and the control of synovial cell growth...
  88. pmc Synovial tissue hypoxia and inflammation in vivo
    C T Ng
    Dublin Academic Medical Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Ann Rheum Dis 69:1389-95. 2010
    ....
  89. ncbi Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis
    Nathalie Busso
    Laboratory of Rheumatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Immunol 168:875-82. 2002
    ..In conclusion, leptin contributes to the mechanisms of joint inflammation in Ag-induced arthritis by regulating both humoral and cell-mediated immune responses...
  90. pmc Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy
    Dominique Baeten
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Arthritis Res Ther 7:R359-69. 2005
    ..These data support a prominent role for innate immune cells in SpA synovitis and warrant further evaluation of synovial histopathology as a surrogate marker in early-phase therapeutic trials in SpA...
  91. pmc Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane
    Cosimo De Bari
    Laboratory for Skeletal Development and Joint Disorders, Dept of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Cell Biol 160:909-18. 2003
    We have demonstrated previously that adult human synovial membrane-derived mesenchymal stem cells (hSM-MSCs) have myogenic potential in vitro (De Bari, C., F. Dell'Accio, P. Tylzanowski, and F.P. Luyten. 2001. Arthritis Rheum...
  92. pmc Regulation by PGE2 of the production of interleukin-6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblasts
    Hideo Inoue
    Research Laboratory, Minophagen Pharmaceutical Co, 2 2 3 Komatsubara, Zama shi, Kanagawa 228 0002, Japan
    Br J Pharmacol 136:287-95. 2002
    ..6. These results suggest that endogenous PGE(2) regulates the production of IL-6, M-CSF, and VEGF by IL-1beta-stimulated human synovial fibroblasts through the activation of EP(2) and EP(4) receptors with increase in cyclic AMP...
  93. ncbi The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera
    H Matsuno
    Department of Orthopedic Surgery, Toyama Medical and Pharmaceutical University, Toyama, UK
    Rheumatology (Oxford) 41:329-37. 2002
    ....
  94. ncbi Joint diseases and matrix metalloproteinases: a role for MMP-13
    Hironari Takaishi
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Curr Pharm Biotechnol 9:47-54. 2008
    ..This review describes a body of research that supports the development of novel selective MMP-13 inhibitors with the hope of developing these compounds in clinical trials for the treatment of arthritis...
  95. pmc Predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult onset Still's disease
    D Y Chen
    Department of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, No 160, Section 3 Taichung Kang Road, Taichung City, 40705 Taiwan
    Ann Rheum Dis 63:1300-6. 2004
    ..To determine the type 1 T helper (Th1)/type 2 T helper (Th2) balance in the peripheral blood (PB) and pathological tissues of patients with active untreated adult onset Still's disease (AOSD)...
  96. ncbi Interleukin 27 attenuates collagen-induced arthritis
    W Niedbala
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Ann Rheum Dis 67:1474-9. 2008
    ....
  97. ncbi PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis
    Silvia Hayer
    Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    FASEB J 23:4288-98. 2009
    ....
  98. ncbi Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Switzerland
    J Bone Joint Surg Am 78:721-33. 1996
    ..Histological studies revealed a continuous layer of mesenchymal cells extending from the synovial membrane across the superficial tangential zone of normal articular cartilage into the defect, indicating that the ..
  99. pmc Regional analysis of p53 mutations in rheumatoid arthritis synovium
    Yuji Yamanishi
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego School of Medicine, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 99:10025-30. 2002
    ..A relatively low percentage of cells containing p53 mutations can potentially affect neighboring cells and enhance inflammation through the elaboration of proinflammatory cytokines...
  100. ncbi Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes
    Saloua Zrioual
    Department of Immunology and Rheumatology and Hospices Civils de Lyon bioMerieux Mixed Research Unit, Hospital Edouard Herriot, Lyon, France
    J Immunol 182:3112-20. 2009
    ..IL-17A and IL-17F are both expressed in RA synovium. In the presence of TNF-alpha, they induced a similar expression pattern in RA synoviocytes. Accordingly, IL-17F appears as a target in Th17-mediated diseases such as RA...
  101. ncbi Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial
    Clarissa E Vergunst
    Academic Medical Center, and University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 58:1931-9. 2008
    ..Blocking CCR2 prevents CCL2-mediated chemotaxis in vitro and modulates arthritis in animal models of RA. In this study we examined the effects of CCR2 blockade on synovial inflammation in RA...

Research Grants65

  1. The Toll-like receptor pathway in Meniscal Injury and Osteoarthritis
    CARLA ROSE SCANZELLO; Fiscal Year: 2013
    ..Perhaps the least understood pathologic change that occurs in the OA joint is the inflammation within the synovial membrane (SM)...
  2. Dual-Energy Cone-Beam Tomographic Imaging and Analysis for Rheumatoid Arthritis
    Jeffrey H Siewerdsen; Fiscal Year: 2013
    ..findings following the current gold standard in image-based assessment [the RA MRI score (RAMRIS)] - namely, synovial membrane volume (SMv), bone marrow edema volume (BMEv), and erosion volume (Ev) - as well as novel metrics of fully ..
  3. Mandibular Cartilage Regeneration In Situ by Endogenous Stem Cell Recruitment
    Wendy S Vanden Berg-Foels; Fiscal Year: 2013
    ..Local MSC sources for synovial joints include the synovial membrane (sMSC) and the bone marrow (bMSC)...
  4. Synovium-based articular cartilage tissue engineering
    Ernst B Hunziker; Fiscal Year: 2010
    ..by introducing an adult stem cell population directly into the defect space by the autotransplantation of synovial membrane flaps, the difficulties can be overcome and the repair of large defect areas and volumes induced...
  5. OPTICAL TOMOGRAPHY FOR THE DIAGNOSIS OF JOINT DISEASES
    ANDREAS HIELSCHER; Fiscal Year: 2007
    ..Based on our studies we now believe that three main processes (effusion, erosion, and hypertrophy of the synovial membrane (synovitis)) that accompany RA can be distinguished by optical tomography (OT)...
  6. GENETIC PREDICTORS OF RESPONSE TO TREATMENT IN EARLY RA
    S Bridges; Fiscal Year: 2001
    Rheumatoid arthritis (RA) is characterized by inflammation in the synovial membrane, often leading to joint destruction. HLA DRB1 alleles containing the shared epitope (SE) influence RA susceptibility and severity...
  7. Transcriptome-based biomarkers in Human Osteoarthritis
    Steven Abramson; Fiscal Year: 2004
    ..The disease process affects the entire joint structure, including cartilage, synovial membrane, subchondral bone, which are active sites of growth factor, cytokine, protease and inflammatory mediator ..
  8. IKKi expression and regulation in rheumatoid arthritis
    Gary Firestein; Fiscal Year: 2005
    ..We propose to test the hypothesis that IKKi is an important signal transduction pathway that regulates inflammation in chronic arthritis and is a novel target for development of anti-rheumatic agents. ..
  9. SYNOVIAL DYSFUNCTION DUE TO P53 ABNORMALITIES IN RA
    Gary Firestein; Fiscal Year: 2006
    ..abstract_text> ..
  10. REGULATION OF PERIPHERAL INFLAMMATION BY THE CNS
    Gary Firestein; Fiscal Year: 2002
    ..These studies will provide a basis for understanding the central nervous system-immune system connection as well as explore novel therapeutic targets. ..
  11. Chemokine receptor antagonists in inflammatory disease
    Shiva Shahrara; Fiscal Year: 2007
    ..Achieving these goals may give us valuable information in regard to molecular inflammatory mechanisms involved in atherosclerosis and RA. ..
  12. TH-1 BIAS IN RHEUMATOID ARTHRITIS
    Laurie Davis; Fiscal Year: 2003
    ..It is anticipated that the information obtained should provide important new insights into the regulatory influences on the differentiation of CD4+ memory effector cells in man. ..
  13. FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERS
    MARY CORR; Fiscal Year: 2004
    ..The results of these studies will both contribute to, and will utilize, the resources of the OA biomarker consortium. ..
  14. Delivery of Therapeutic Genes to Osteoarthritic Joints
    Christopher Evans; Fiscal Year: 2002
    ....
  15. Signaling Molecules and Long Bone Formation
    Maurizio Pacifici; Fiscal Year: 2005
    ..The results will provide much needed information on the regulation of long bone formation, and will have relevance to questions of skeletal growth, fracture repair and congenital conditions of cartilage and bone. ..
  16. Lanthanides as Novel Anti-Arthritic Agents
    Christopher Evans; Fiscal Year: 2004
    ..A successful outcome to these studies will have identified the basis for a potential new, very inexpensive anti-rheumatic agent whose mode of action differs from that of existing drugs. ..
  17. AAOS/NIH Mulit-Year Research Symposia for 2005-2009
    Christopher Evans; Fiscal Year: 2005
    ....
  18. REGULATION OF CHONDROCYTE PROLIFERATION
    Maurizio Pacifici; Fiscal Year: 2002
    ....
  19. Novel Nanostructured Calcium Phosphate for Gene Delivery to Bone
    Christopher Evans; Fiscal Year: 2005
    ..2. To evaluate the ability of nCaP-vector constructs to enhance osteogenic responses in vivo. ..
  20. Role of the 4A11 antigen in rheumatoid arthritis
    Mohammad Amin; Fiscal Year: 2008
    ..Targeting this antigen may provide a potential therapeutic to RA. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  21. Mechanisms of Synovial Joint Formation
    Maurizio Pacifici; Fiscal Year: 2009
    ..The results will be invaluable in conceiving novel, directed and specific therapies to repair and restore malfunctioning joints common to aging individuals and otherwise affected patients. ..
  22. EFFECT OF COMP MUTATION ON MUSCULOSKELETAL DEVELOPMENT
    Paul Di Cesare; Fiscal Year: 2002
    ..Identifying the functions, synthesis, interactions, tissue distribution and expression of COMP is critical to understanding its influence on growth during endochondral ossification and articular cartilage structure and function. ..
  23. Accelerated arthritis in E and P selectin deficient mice
    Jeffrey Ruth; Fiscal Year: 2007
    ..While common dogma suggests IL-1beta regulates selectins, this study proposes the novel hypothesis that in vivo E- and P-selectins regulate IL-1beta production and CIA development. [unreadable] [unreadable] [unreadable]..
  24. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007
    ....
  25. Tissue engineered osteochondral patella resurfacing
    James Cook; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Innate immunity and experimental Lyme arthritis
    Charles Brown; Fiscal Year: 2007
    ..As such these studies; may have important implications not only for Lyme disease, but for other inflammatory diseases as well. ..
  27. THE ROLE OF p204 IN OSTEOGENESIS
    Chuanju Liu; Fiscal Year: 2007
    ..A greater understanding of the process of how bone is generated can lead to new therapies which can help stem or reverse the course of these diseases. [unreadable] [unreadable] [unreadable]..
  28. Mucin expression in rheumatoid arthritis
    MICHAEL VOLIN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. The Interaction of Mechanical Load and Inflammation in Tendon-Bone Healing
    Scott A Rodeo; Fiscal Year: 2010
    ..The results of our studies will allow a scientific basis for the design of post- operative rehabilitation prescription. ..
  30. Eicosanoid regulation of experimental Lyme arthritis
    Charles R Brown; Fiscal Year: 2010
    ..This information will further our understanding of how inflammation is regulated and allow the design of more effective anti-inflammatory treatments. ..
  31. Interferon Regulation in Systemic Lupus
    Lionel B Ivashkiv; Fiscal Year: 2010
    ..These experiments will yield insight into the molecular pathogenesis of SLE and identify novel therapeutic approaches to manipulatecytokine activity in SLE at the level of signal transduction. ..
  32. CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASE
    Alan Hudson; Fiscal Year: 2002
    ..Such new information may well provide important new insights for development of novel therapeutic modalities to prevent or ameliorate late-onset AD. ..
  33. Epigenetic Regulation of MMP-13
    MARY GOLDRING; Fiscal Year: 2008
    ..The proposed studies will advance considerably our understanding about the importance of DNA methylation in the pathology of OA. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  34. The role BH3 and multi BH domain genes in regulating monocyte survival and functi
    Harris Perlman; Fiscal Year: 2008
    ..Further our goal is to characterize mice lacking Bim or it signaling partners only in monocytes and macrophages. [unreadable] [unreadable] [unreadable]..
  35. Reiter's syndrome mechanism of chlamydial pathogenesis
    Alan Hudson; Fiscal Year: 2008
    ....
  36. Innate Immunity in gouty Inflammation
    RU BRYAN; Fiscal Year: 2008
    ..Completion of this work will help further understanding the mechanisms of acute gouty inflammation, how to control gouty arthritis and potentially other forms of crystal-induced inflammation. [unreadable] [unreadable] [unreadable]..
  37. Determination of OA Pathology by Biomarker Dating
    Virginia Kraus; Fiscal Year: 2007
    ..We refer to the technique of quantifying the D-aspartate content of cartilage macromolecules as "biomarker dating". ..
  38. Immune Tolerance after Severe Immunosuppression and Stem Cell Rescue for JIA
    Yukiko Kimura; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  39. Activation of Cutaneous Mechanoreceptors by Shear Stress
    Peter Grigg; Fiscal Year: 2007
    ..In this proposal we propose to dynamically manipulate shear stress, and measure shear strain, in an attempt to determine whether activation of afferent neurons is caused by shear or normal components of stress or strain. ..
  40. STRATEGIES TO PREDICT OSTEOARTHRITIS PROGRESSION
    Virginia Kraus; Fiscal Year: 2006
    ..The results of these studies could aid in the refinement of subject selection for clinical trials and those most in need of prevention strategies. ..
  41. Role of fractalkine signaling in rheumatoid arthritis
    James Woods; Fiscal Year: 2004
    ..These experiments should provide extensive new insights about the mechanism of fkn signaling through CX3CR1 and its relationship to cellular function. ..
  42. CD1 IMMUNE RESPONSES AND VACCINES IN ANIMAL MODELS OF TB
    Michael Brenner; Fiscal Year: 2004
    ..Together, these studies will move forward our understanding of the basic biology of CD1 antigen presentation during microbial infection in vivo with applications of this emerging biology to vaccine development. ..
  43. Physical Regulation of Skeletal Repair Workshop
    Roy Aaron; Fiscal Year: 2003
    ..Finally, how repairing skeletal tissues organize physical information to augment the repair process, and what translational opportunities exist, will be considered. ..
  44. Induction of Apoptosis in Synovial Fibroblasts
    Haidi Zhang; Fiscal Year: 2003
    Rheumatoid arthritis is characterized by hyperplasia of synovial membrane and bone destruction...
  45. IL-1 and IL-1ra Stimulation of S aureus Replication
    SIVADASAN KANANGAT; Fiscal Year: 2003
    ..A better understanding of how bacteria such as S. aureus use IL-1 family of cytokines to replicate and defeat the host defense is highly relevant to the study of septic arthritis. ..
  46. T CELL RECEPTOR GAMMA/DELTA
    Michael Brenner; Fiscal Year: 2002
    ..Studies that define ligand specificities of gamma/delta T-cells are essential to understanding the biological role of this ubiquitous but still enigmatic class of lymphocytes. ..
  47. METALLOPROTEINASES IN AGING AND OSTEOARTHRITIS
    Virginia Kraus; Fiscal Year: 2002
    ..They propose that successful completion of this work will serve as a basis for future studies of drug intervention for OA, and characterization and interaction of other pathogenic molecules in OA. ..
  48. Annotation of the Mycoplasma alligatoris genome
    Daniel Brown; Fiscal Year: 2002
    ..The ease of PCR-based cloning and the accessibility of bioinformatics software make this an ideal project to engage undergraduate students in innovative biomedical research. ..
  49. EVALULATION OF CARTILAGE GROWN FROM RIB PERICHONDRIUM
    Richard Coutts; Fiscal Year: 2001
    ..The goal is to develop an implant that will consistently and predictably produce repairs of full-thickness articular cartilage defects that will function as well as normal cartilage. ..
  50. CHONDROPROTECTION BY A NOVEL RETINOID AND TRITERPENOID
    Matthew Vincenti; Fiscal Year: 2004
    ..This work will examine cellular/molecular events and whole animal models to characterize the chondroprotective potential of a novel steroid and a novel retinoid for the treatment of arthritis. ..
  51. BIOLOGICAL EFFECTS OF BASIC CALCIUM PHOSPHATE CRYSTALS
    Herman Cheung; Fiscal Year: 2004
    ..Hypothesis 5: There are specific cis elements in the promotor of Tissue Inhibitor of Metalloproteinase (TIMP)-2 that regulate crystal inhibition of TIMP- 2 expression. ..
  52. Fas Ligand Gene Transfer Apoptosis Synovial Fibroblasts
    Haidi Zhang; Fiscal Year: 2004
    DESCRIPTION (provided by the applicant): Rheumatoid arthritis (RA) is characterized by hyperplasia of synovial membrane and bone destruction...
  53. CD80 binding peptides as therapeutic agents in arthritis
    Mythily Srinivasan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. IL-8 in chondrocalcinosis
    RU BRYAN; Fiscal Year: 2005
    ..The completion of this study has the potential to provide a foundation for novel chemokine and signal transduction-based therapeutic strategies for treatment of chondrocalcinosis in OA and aging. ..
  55. KCNRG gene as candidate tumor suppressor for CLL and MM
    Anna Baranova; Fiscal Year: 2005
    ..Common gene changes revealed by activation of KCNRG will be confirmed in Real-Time PCR experiments. ..
  56. REGULATION OF MATRIX GENE EXPRESSION IN CHONDROCYTES
    MARY GOLDRING; Fiscal Year: 2001
    ....
  57. ROLE OF INTEGRIN ALPHA E BETA 7 IN IMMUNE RESPONSES
    Michael Brenner; Fiscal Year: 2005
    ..abstract_text> ..
  58. EXPRESSION OF MATRIX METALLOPROTEINASE AND P53
    Yubo Sun; Fiscal Year: 2004
    ..Once the molecular mechanism addressed in this proposal is clearly defined, it may be possible to exploit the information gained for the development of an effective strategy for RA treatment. ..
  59. COORDINATE REGULATION OF APOPTOSIS AND CELL CYCLE IN RA
    Harris Perlman; Fiscal Year: 2004
    ..This approach could lead to the development of a new therapeutic strategy for gene therapy in patients with rheumatoid arthritis. ..
  60. THE FUNCTION OF T-BET IN T HELPER CELL DEVELOPMENT
    Stanford Peng; Fiscal Year: 2003
    ..abstract_text> ..
  61. GTPase Activating Proteins in Aging and Osteoarthritis
    Lisa Fortier; Fiscal Year: 2007
    ..We anticipate that these findings will facilitate identification of target molecules for development of therapeutics modalities for OA. [unreadable] [unreadable] [unreadable]..
  62. Estrogenic Regulation of Inflammation Related to TMJD
    Phillip Kramer; Fiscal Year: 2006
    ..The function of estrogen receptors ER alpha and/or ER beta will be directly addressed pharmacologically (e.g., antiestrogen) and through mutation studies of the Fc gamma RIIIA promoter. ..
  63. Estrogenic LXR Alpha Response /Cholesterol Homeostasis
    Phillip Kramer; Fiscal Year: 2003
    ..abstract_text> ..