- Mast cells: a cellular link between autoantibodies and inflammatory arthritis
David M Lee
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 297:1689-92. 2002
..Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis...
- Musculoskeletal ultrasound including definitions for ultrasonographic pathology
Richard J Wakefield
Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
J Rheumatol 32:2485-7. 2005
..advantages over magnetic resonance imaging, including good patient tolerability and ability to scan multiple joints in a short period of time...
- ISB recommendation on definitions of joint coordinate systems of various joints for the reporting of human joint motion--Part II: shoulder, elbow, wrist and hand
Department of Physical Therapy, University of Vermont, 305 Rathwell Building, Burlington, VT, USA
J Biomech 38:981-992. 2005
..Adopting these standards will lead to better communication among researchers and clinicians...
- Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structu
Joel M Kremer
Albany Medical College and Center for Rheumatology, Albany, New York 12206, USA
Arthritis Rheum 63:609-21. 2011
- Evidence that cytokines play a role in rheumatoid arthritis
Fionula M Brennan
Kennedy Institute of Rheumatology, Imperial College London, London, UK
J Clin Invest 118:3537-45. 2008
A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA)...
- ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion--part I: ankle, hip, and spine. International Society of Biomechanics
J Biomech 35:543-8. 2002
..In this communication, the STC proposes definitions of JCS for the ankle, hip, and spine. Definitions for other joints (such as shoulder, elbow, hand and wrist, temporomandibular joint (TMJ), and whole body) will be reported in later ..
- A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
Velandai K Srikanth
The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
Osteoarthritis Cartilage 13:769-81. 2005
..To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity...
- Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial
University of Lund, Lund, Sweden
Arthritis Rheum 52:3360-70. 2005
..To assess the efficacy of low-dose prednisolone on joint damage and disease activity in patients with early rheumatoid arthritis (RA)...
- A simplified disease activity index for rheumatoid arthritis for use in clinical practice
J S Smolen
University of Vienna and Lainz Hospital, Austria
Rheumatology (Oxford) 42:244-57. 2003
..The objective of this study was to verify the usefulness of a simple disease activity index (SDAI) for rheumatoid arthritis (RA)...
- The uncontrolled manifold concept: identifying control variables for a functional task
J P Scholz
Physical Therapy Department, McKinly Laboratory, University of Delaware, Newark 19716, USA
Exp Brain Res 126:289-306. 1999
..The horizontal head position and the position of the hand were controlled less stably, while vertical head position appears to be no more controlled than joint motions...
- EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
Immuno Rhumatologie, Lapeyronie Hosp, Montpellier, France
Ann Rheum Dis 66:34-45. 2007
..To formulate EULAR recommendations for the management of early arthritis...
- Rheumatoid arthritis progression mediated by activated synovial fibroblasts
Dept of Internal Medicine and Rheumatology, Justus Liebig University Giesen, Kerckhoff Klinik, Benekestr 2 8, D 61231 Bad Nauheim, Germany
Trends Mol Med 16:458-68. 2010
..Here, we review new findings regarding RASF activation and their altered behavior that contribute to matrix destruction and inflammation as well as their potential to spread RA...
- Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis
Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Arthritis Rheum 60:2294-303. 2009
..The involvement of IL-17-producing gamma/delta T cells in SKG mice with autoimmune arthritis and patients with rheumatoid arthritis (RA) was also investigated...
- Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression
A K Brown
Chapel Allerton Hospital, University of Leeds, Leeds, UK
Arthritis Rheum 54:3761-73. 2006
..This questions the validity of current methods of assessing remission in RA. The purpose of this study was to test the hypothesis that modern joint imaging improves the accuracy of remission measurement in RA...
- Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
L J Brunet
Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720 3204, USA
Science 280:1455-7. 1998
..Excess BMP activity in the absence of Noggin antagonism may enhance the recruitment of cells into cartilage, resulting in oversized growth plates; chondrocytes are also refractory to joint-inducing positional cues...
- Disconnect between inflammation and joint destruction after treatment with etanercept plus methotrexate: results from the trial of etanercept and methotrexate with radiographic and patient outcomes
University Hospital Maastricht, Maastricht, The Netherlands
Arthritis Rheum 54:3119-25. 2006
- Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
P E Lipsky
University of Texas Southwestern Medical Center at Dallas, USA
N Engl J Med 343:1594-602. 2000
..However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are not known...
- Whole limb kinematics are preferentially conserved over individual joint kinematics after peripheral nerve injury
Young Hui Chang
Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Exp Biol 212:3511-21. 2009
..This may represent a fundamental compensation principle allowing animals to adapt to changing conditions with minimal effect on overall locomotor function...
- Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression
Hospital Severo Ochoa, Madrid, Spain
Arthritis Rheum 57:116-24. 2007
- A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Interferon Cytokine Res 31:927-40. 2011
..important role in the pathogenesis of rheumatoid arthritis (RA), an autoimmune disease that targets the synovial joints. The cytokine environment in the peripheral lymphoid tissues and the target organ (the joint) has a strong ..
- Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences
Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
Mol Microbiol 69:15-29. 2008
..Taken together, the study demonstrated that the surface lipoproteins provide B. burgdorferi with an essential protective function against host innate elimination...
- Tri-dimensional and triphasic muscle organization of whole-body pointing movements
Italian Institute of Technology, Via Morego 30, 16163 Genoa, Italy
Neuroscience 170:1223-38. 2010
..In particular, those associated with the muscles of the lower-body joints (ankle, knee and hip) always presented the three sequences in all conditions...
- EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis
Alexandra N Colebatch
Department of Rheumatology, University Hospital Southampton, Southampton, UK
Ann Rheum Dis 72:804-14. 2013
To develop evidence-based recommendations on the use of imaging of the joints in the clinical management of rheumatoid arthritis (RA).
- Production of canine mesenchymal stem cells from adipose tissue and their application in dogs with chronic osteoarthritis of the humeroradial joints
Area Diagnostica Virologica dellIstituto Zooprofilattico Sperimentale della Sicilia A Mirri, Palermo, Italy
Cell Biol Int 36:189-94. 2012
..injection of AD-MSCs was evaluated on 4 dogs with lameness associated with OA (osteoarthritis) of the humeroradial joints. MSCs were readily isolated from adult dog adipose tissue, and their ability to form colony and differentiate into ..
- Power Doppler ultrasound, but not low-field magnetic resonance imaging, predicts relapse and radiographic disease progression in rheumatoid arthritis patients with low levels of disease activity
University of Paris VI and Rheumatology Department, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Arthritis Rheum 64:67-76. 2012
..The aim of this study was to compare the ability of ultrasonography and magnetic resonance imaging (MRI) to predict relapse and radiographic progression in these patients...
- EMG-based simultaneous and proportional estimation of wrist/hand kinematics in uni-lateral trans-radial amputees
Strategic Technology Management, OttoBock HealthCare GmbH, Max Näder Str 15, Duderstadt, 37115, Germany
J Neuroeng Rehabil 9:42. 2012
..The results from the current study demonstrated the feasibility of the proposed myoelectric control approach to provide a more intuitive myoelectric control strategy for unilateral transradial amputees...
- Kinematics of gait: new method for angle estimation based on accelerometers
Milica D Djurić-Jovičić
School of Electrical Engineering, University of Belgrade, Bulevar kralja Aleksandra 73, Belgrade, Serbia
Sensors (Basel) 11:10571-85. 2011
A new method for estimation of angles of leg segments and joints, which uses accelerometer arrays attached to body segments, is described. An array consists of two accelerometers mounted on a rigid rod...
- Unloading joints to treat osteoarthritis, including joint distraction
Floris P J G Lafeber
Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands
Curr Opin Rheumatol 18:519-25. 2006
..This review examines the recent literature on the potential beneficial effects of unloading joints in the treatment of osteoarthritis, with a focus on joint distraction.
- Is osteoarthritis a systemic disorder of bone?
University of East Anglia, Norwich, UK
Arthritis Rheum 50:452-7. 2004
To describe the osteologic findings associated with osteoarthritis (OA) of a variety of joints.
- Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 50:650-9. 2004
..This T cell cytokine is implicated in the initiation phase of arthritis. However, the role of IL-17 during the effector phase of arthritis has still not been identified; this was the objective of the present study...
- Enhancement of collagen-induced arthritis in mice genetically deficient in extracellular superoxide dismutase
Aron D Ross
National Jewish Medical and Research Center, Denver, Colorado, USA
Arthritis Rheum 50:3702-11. 2004
..To examine the influence of superoxide on the severity of collagen-induced arthritis (CIA) in mice...
- The kinaesthetic senses
Department of Physiology, PO Box 13F, Monash University, Clayton, Victoria 3800, Australia
J Physiol 587:4139-46. 2009
..Joint receptors do not appear to play a major role at most joints. The evidence supports the existence of two separate senses, the sense of limb position and the sense of limb ..
- Physiological characteristics of low-threshold mechanoreceptors in joints, muscle and skin in human subjects
Vaughan G Macefield
Prince of Wales Medical Research Institute and University of New South Wales, Sydney, New South Wales, Australia
Clin Exp Pharmacol Physiol 32:135-44. 2005
..detailed analyses of the signalling capacities of single mechanoreceptive afferents from the skin, muscles and joints. For example, we know much about how the two classes of rapidly adapting (Meissner and Pacinian) and two classes ..
- Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
Nat Med 8:831-40. 2002
..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
- A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis
A H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Centre, PO Box 9600, 2300RC Leiden, The Netherlands
Ann Rheum Dis 67:769-74. 2008
..Rheumatoid arthritis (RA) is marked by the presence of proinflammatory cytokines and, in general, the presence of high levels of inflammatory markers is associated with a severe disease course and joint damage...
- A 78-joints ultrasonographic assessment is associated with clinical assessments and is highly responsive to improvement in a longitudinal study of patients with rheumatoid arthritis starting adalimumab treatment
Hilde Berner Hammer
Department of Rheumatology, Diakonhjemmet Hospital, Box 23, Vinderen, N 0319 Oslo, Norway
Ann Rheum Dis 69:1349-51. 2010
..associations between ultrasonography (US) assessments (B-mode (BM) and power Doppler (PD)) of a large number of joints and traditional assessments of disease activity, and to examine the sensitivity to change of the US scores and ..
- Mobility of the pelvic joints in pregnancy-related lumbopelvic pain: a systematic review
Jan M A Mens
Institute of Rehabilitation Medicine, Department of Neuroscience, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Obstet Gynecol Surv 64:200-8. 2009
..It has been suggested that increased motion of the three joints in the pelvic ring is one of the causes of PLPP...
- Efficient management of rheumatoid arthritis significantly reduces long-term functional disability
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
Ann Rheum Dis 67:1153-8. 2008
..The aim of this study was to examine the effect of efficient management of rheumatoid arthritis (RA) in relation to disability levels in a large cohort of patients with RA over a period of 3 years...
- An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents
Mark C Genovese
Division of Immunology and Rheumatology, Stanford University, Palo Alto, California, USA
Arthritis Rheum 63:337-45. 2011
..To assess the efficacy and safety of R788 (fostamatinib disodium), an inhibitor of spleen tyrosine kinase (Syk), in patients with active rheumatoid arthritis (RA) that did not respond to biologic therapies...
- Classification of rheumatoid arthritis: comparison of the 1987 American College of Rheumatology criteria and the 2010 American College of Rheumatology/European League Against Rheumatism criteria
M P M van der Linden
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 63:37-42. 2011
- Action and perception at the level of synergies
M T Turvey
Center for the Ecological Study of Perception and Action, University of Connecticut, Storrs, CT, USA
Hum Mov Sci 26:657-97. 2007
..Coverage is given to symmetry groups, task space, order parameters, metastability, biotensegrity, allometric scaling, and impredicative definitions...
- Estimation and visualization of sagittal kinematics of lower limbs orientation using body-fixed sensors
Ecole Polytechnique Federale de Lausanne EPFL, Laboratory of Movement Analysis and Measurement, 1015 Lausanne, Switzerland
IEEE Trans Biomed Eng 53:1385-93. 2006
..The model is based on estimating the accelerations of ankle and knee joints by placing virtual sensors at the centers of rotation...
- Control and estimation of posture during quiet stance depends on multijoint coordination
Wei Li Hsu
Dept of Physical Therapy, Biomechanics and Movement Science Program, 307 McKinly Laboratory, University of Delaware, Newark, DE 19716, USA
J Neurophysiol 97:3024-35. 2007
This study tested the hypotheses that all major joints along the longitudinal axis of the body are equally active during quiet standing and that their motions are coordinated to stabilize the spatial positions of the center of mass (CM) ..
- Less radiographic progression with adalimumab plus methotrexate versus methotrexate monotherapy across the spectrum of clinical response in early rheumatoid arthritis
Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, United Kingdom
J Rheumatol 36:1429-41. 2009
..To determine the relationship between radiographic progression and clinical response for adalimumab plus methotrexate (MTX) versus either monotherapy in patients with early rheumatoid arthritis (RA) in the PREMIER study...
- Deletion of either CD55 or CD97 ameliorates arthritis in mouse models
Robert M Hoek
Academic Medical Center, Amsterdam, The Netherlands
Arthritis Rheum 62:1036-42. 2010
..This study was undertaken to investigate the role of CD55 in experimental RA...
- The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
David K Rhee
Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
J Clin Invest 115:622-31. 2005
..In order to delineate the mechanism by which lubricin protects joints, we studied the expression of Prg4 mRNA during mouse joint development, and we created lubricin-mutant mice...
- Temporal analysis of pathogenic events in virulent and avirulent Brucella melitensis infections
Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, 53706, USA
Cell Microbiol 7:1459-73. 2005
..Sublethal infection of IRF-1(-/-) mice resulted in chronic Brucella localization in tail joints, an infection parallel to osteoarticular brucellosis in humans...
- Retrospective clinical study on the notable efficacy and related factors of infliximab therapy in a rheumatoid arthritis management group in Japan: one-year clinical outcomes (RECONFIRM-2)
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Mod Rheumatol 18:146-52. 2008
..2%, respectively. In conclusion, we reconfirmed the clinical efficacy of infliximab and demographic factors related to the efficacy over a 54-week study period in 410 Japanese patients with RA using DAS28-CRP and EULAR response criteria...
- Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferi
Department of Pathobiological Sciences, Louisiana State University, Skip Bertman Drive at River Road, Baton Rouge, LA 70803, USA
Infect Immun 76:1239-46. 2008
..Taken together, the study results indicate that neither DbpA nor DbpB is essential for mammalian infection but that both are critical for the overall virulence of B. burgdorferi...
- Genetic variation and genetic trends in hip and elbow dysplasia in Swedish Rottweiler and Bernese Mountain Dog
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
J Anim Breed Genet 125:403-12. 2008
..Based on the results, a statistical model for routine prediction of breeding values for HD and ED in Swedish dogs was suggested...
- Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family
N M Wolfman
Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
J Clin Invest 100:321-30. 1997
..In addition, comparative in situ localizations of the GDF-5, 6, and 7 mRNAs suggest that these molecules are important regulatory components of synovial joint morphogenesis...
- Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation
Kingston Kinglun Mak
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Development 133:3695-707. 2006
..However, there is a strong synergistic interaction between Wnt/beta-catenin and Ihh signaling in regulating synovial joint formation...
- Osteoarthritis cartilage histopathology: grading and staging
K P H Pritzker
Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
Osteoarthritis Cartilage 14:13-29. 2006
..Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method...
- Pathophysiology of spastic paresis. II: Emergence of muscle overactivity
Jean Michel Gracies
Department of Neurology, Mount Sinai Medical Center, One Gustave L Levy Place, Annenberg 2 Box 1052, New York, New York 10029 6574, USA
Muscle Nerve 31:552-71. 2005
..is symmetrically distributed between agonists and antagonists, which generates torque imbalance around joints and limb deformities. Thus, each may be best treated focally on an individual muscle-by-muscle basis...
- Efficacy of etanercept for the treatment of juvenile idiopathic arthritis according to the onset type
Hopital Necker Enfants Malades, Paris, France
Arthritis Rheum 48:1093-101. 2003
..To assess the efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA), and to assess the tolerance of these patients to etanercept...
- Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan: results from a retrospective study (REACTION study)
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
Mod Rheumatol 21:122-33. 2011
..Tocilizumab infusion is therefore applicable not only as an alternative approach for anti-TNF therapy-resistant patients, but also as primary biologic therapy for active RA patients...
- Effect of fluid boundary conditions on joint contact mechanics and applications to the modeling of osteoarthritic joints
Dipartimento di Ingegneria Industriale e Meccanica, Facolta di Ingegneria, Universita degli Studi di Catania, Catania, Italy
J Biomech Eng 126:220-5. 2004
..These findings agree well with experimental observations...
- Lubrication at physiological pressures by polyzwitterionic brushes
Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford OX1 3QZ, UK
Science 323:1698-701. 2009
The very low sliding friction at natural synovial joints, which have friction coefficients of mu < 0...
- Reaching to grasp with a multi-jointed arm. I. Computational model
Elizabeth B Torres
Division of Biology, California Institute of Technology, Pasadena 91125, California, USA
J Neurophysiol 88:2355-67. 2002
..Simulated orientation-matching movements are compared with actual human movement data to assess the validity of several of the model's behavioral predictions...
- Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton
Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3706, USA
Dev Biol 332:383-95. 2009
..A prominent and consistent phenotype of these mutations is a remodeling of the cranio-cervical joints whose major feature is the assimilation of the atlas into the basioccipital bone so that the skull rests on the ..
- Collagen morphology in human skin and scar tissue: no adaptations in response to mechanical loading at joints
Paul P M van Zuijlen
Burn Centre and Department of Surgery, Red Cross Hospital, Vondellaan 13, 1942 LE Beverwijk, The Netherlands
Burns 29:423-31. 2003
..mechanical tension during scarring, which may explain the problematic scar formation that occurs specifically at joints. Scar tissue and normal skin were biopsied from joints and control areas and evaluated by the Fourier analysis...
- Denosumab for joints and bones
E Michael Lewiecki
New Mexico Clinical Research and Osteoporosis Center, 300 Oak Street NE, Albuquerque, NM 87106, USA
Curr Rheumatol Rep 11:196-201. 2009
..It is generally well tolerated, with a good safety profile. Adverse and serious adverse events, including infections and malignancy, are similar in patients treated with denosumab or placebo...
- Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 production
University of Florida, P O Box 100221, Gainesville, FL 32610 0221, USA
J Leukoc Biol 76:227-36. 2004
..PGE(2) can modulate inflammatory reactions via the EP2/4 receptor through its regulation of TNF-alpha and IL-6. Modification of EP signaling may be a new therapeutic strategy in inflammatory/autoimmune diseases...
- The differential expressions of 78-kDa glucose-regulated protein of infiltrating plasma cells in peripheral joints with the histopathological variants of rheumatoid synovitis
Department of Clinical Immunology, State Key Discipline of Cell Biology, Xijing Hospital, Fourth Military Medical University, 17 Changlexi Street, Xi an 710032, Shaanxi, PR China
Arthritis Res Ther 11:R4. 2009
..explore the potential links between the activation of the UPR of infiltrating plasma cells in inflamed peripheral joints and the histopathological variants of rheumatoid synovitis as well as the local production of pathogenic ..
- Reproducibility of joint swelling assessments in long-lasting rheumatoid arthritis: influence on Disease Activity Score-28 values (SEA-Repro study part I)
Rheumatology Unit, CHU, and University Hospital La Cavale Blanche, Brest, France
J Rheumatol 37:932-7. 2010
..To evaluate the reproducibility of clinical synovitis assessments in rheumatoid arthritis and the effect of variability on the Disease Activity Score-28 (DAS28)...
- Activated memory B cells may function as antigen-presenting cells in the joints of children with juvenile idiopathic arthritis
Vivantes Children s Hospital, Berlin Friedrichshain, Germany Children s Hospital and University of Würzburg, Wurzburg, Germany
Arthritis Rheum 63:3458-66. 2011
..This study was undertaken to investigate whether synovial B cells in patients with juvenile idiopathic arthritis (JIA) might display features of APCs...
- scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints
R S Watson
Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL 32608 0137, USA
Gene Ther 20:670-7. 2013
..the equine joint as a model for adeno-associated virus (AAV)-mediated gene transfer to large, weight-bearing human joints. A self-complementary AAV2 vector containing the coding regions for human interleukin-1-receptor antagonist (hIL-..
- Joint damage in rheumatoid arthritis progresses in remission according to the Disease Activity Score in 28 joints and is driven by residual swollen joints
Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
Arthritis Rheum 63:3702-11. 2011
..The Disease Activity Score in 28 joints (DAS28) has been criticized for the amount of disease activity that remains in patients despite their achieving ..
- Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis
Centre for Bone and Arthritis Research, The Sahlgrenska Academy, University of Gothenburg, Box 480, 405 30 Gothenburg, Sweden
Arthritis Res Ther 13:R96. 2011
- Therapeutic effects of TACI-Ig on rats with adjuvant-induced arthritis via attenuating inflammatory responses
Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti inflammatory and Immunopharmacology of Education Ministry of China, Hefei 230032, PR China
Rheumatology (Oxford) 50:862-70. 2011
- Patient-cooperative control increases active participation of individuals with SCI during robot-aided gait training
Sensory Motor Systems Lab, Institute of Robotics and Intelligent Systems, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland
J Neuroeng Rehabil 7:43. 2010
..In this study, we have investigated the immediate effects of patient-cooperative versus non-cooperative robot-aided gait training on individuals with incomplete spinal cord injury (iSCI)...
- The internal model and the leading joint hypothesis: implications for control of multi-joint movements
Department of Kinesiology, Arizona State University, P O Box 870404, Tempe, AZ 85287 0404, USA
Exp Brain Res 166:1-16. 2005
- Osteosarcoma near joints: assessment and implications
Gerald M Y Quan
Department of Orthopaedics, St Vincent s Hospital, Melbourne, Australia
J Surg Oncol 91:159-66. 2005
The choice of performing surgery when tumors encroach onto joints remains a challenging and controversial issue...
- Shape of articular surface of crocodilian (Archosauria) elbow joints and its relevance to sauropsids
Shin ichi Fujiwara
The University Museum, The University of Tokyo, Bunkyo ku, Tokyo, Japan
J Morphol 271:883-96. 2010
..This study aims at describing the shape of the articular cartilages in the elbow joints of six crocodilian specimens; comparing its structure with that of four birds, three testudines, and five ..
- Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints
Key Laboratory for Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, PR China
Bone 51:212-7. 2012
..We previously detected measurable transport of solute across the mineralized calcified cartilage in normal joints, suggesting a potential cross-talk between subchondral bone and cartilage...
- IL-27-producing CD14(+) cells infiltrate inflamed joints of rheumatoid arthritis and regulate inflammation and chemotactic migration
Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
Cytokine 55:237-44. 2011
..However, the origin and effects of IL-27 in joints of rheumatoid arthritis (RA) remain unclear...
- Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort
Division of Rheumatology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Ann Rheum Dis 66:633-8. 2007
- The ability of synovitis to predict structural damage in rheumatoid arthritis: a comparative study between clinical examination and ultrasound
Hopital Cochin, Rheumatology, Clinique de Rhumatologie B, Groupe Hospitalier Cochin, Paris 75014, France
Ann Rheum Dis 72:665-71. 2013
..To evaluate synovitis (clinical vs ultrasound (US)) to predict structural progression in rheumatoid arthritis (RA)...
- American College of Rheumatology provisional criteria for defining clinical inactive disease in select categories of juvenile idiopathic arthritis
Carol A Wallace
Seattle Children s Hospital and University of Washington School of Medicine, Seattle
Arthritis Care Res (Hoboken) 63:929-36. 2011
..To prospectively validate the preliminary criteria for clinical inactive disease (CID) in patients with select categories of juvenile idiopathic arthritis (JIA)...
- Potential role of fibroblast-like synoviocytes in joint damage induced by Brucella abortus infection through production and induction of matrix metalloproteinases
IDEHU, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956 4to piso, 1113 Buenos Aires, Argentina
Infect Immun 79:3619-32. 2011
..These results suggest that FLS, and phagocytes recruited by them to the infection focus, may be involved in joint damage during brucellar arthritis through the production of MMPs and proinflammatory mediators...
- Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis
University of California at San Diego School of Medicine, La Jolla La Jolla, California 92093, USA
Am J Pathol 160:123-30. 2002
..In contrast, the joints of p53(-/-) DBA/1 animals with CIA showed increased severity of arthritis using clinical and histological scoring ..
- Inflammatory joint manifestations are prevalent in psoriasis: prevalence study of joint and axial involvement in psoriatic patients, and evaluation of a psoriatic and arthritic questionnaire
Gerd Marie Alenius
Division of Rheumatology, University Hospital, Umea, Sweden
J Rheumatol 29:2577-82. 2002
..the question "Have you ever thought you might have arthritis?" in combination with morning stiffness in peripheral joints for at least 60 min, had a sensitivity of 30% and a specificity of 91...
- Normal and prosthetic synovial joints are lubricated by surface-active phospholipid: a hypothesis
B A Hills
Mater Children s Hospital and Department of Medicine university of Queensland, Queensland University ot Technology, Brisbane, Australia
J Arthroplasty 18:499-505. 2003
..This, in turn, leads to the replenishment of SAPL, as tested in OA, and the concept of prelubricating prostheses before implantation...
- Candidate early predictors for progression to joint damage in systemic juvenile idiopathic arthritis
Department of Pediatrics, Stanford University School of Medicine, University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
J Rheumatol 33:2322-9. 2006
..To assess if joint damage at 2 years after diagnosis in patients with systemic juvenile idiopathic arthritis (SJIA) can be predicted by clinical or laboratory features assessed up to 3 or 6 months after diagnosis...
- Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs 7624, Szigeti u 12, Hungary
J Pharmacol Exp Ther 314:111-9. 2005
..Histological examination and scoring of the tibiotarsal joints revealed marked arthritic changes in wild-type mice...
- The effects of oral glucosamine on joint health: is a change in research approach needed?
J A Block
Department of Internal Medicine Rheumatology, Rush University Medical Center, Chicago IL 60612, USA
Osteoarthritis Cartilage 18:5-11. 2010
..Here, we review the state of knowledge concerning the biology of GlcN as it relates to OA, and discuss a framework for future research directions...
- Galanin influences the mechanosensitivity of sensory endings in the rat knee joint
Physiologisches Institut, Universitat Wurzburg, Röntgenring 9, D 97070 Wurzburg, Germany
Eur J Neurosci 12:1567-72. 2000
..effect of galanin on group III and IV afferent nerve fibres (n = 53) innervating normal and acutely inflamed knee joints in rats. They responded to local mechanical stimulation, movements of the joint and i.a...
- The role of the lumbar facet joints in spinal stability. Identification of alternative paths of loading
T R Haher
Department of Orthopaedics, SUNY HSC at Brooklyn
Spine (Phila Pa 1976) 19:2667-70 discussion 2671. 1994
STUDY DESIGN. The role of the facet joints in spinal stability was analyzed using long-segment cadaver spines. OBJECTIVES. To establish the existence of alternate paths of loading when the facet joints and anulus are compromised...
- Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage
S B Abramson
Department of Rheumatology, Hospital for Joint Diseases, New York University of Medicine, 301 East 17th Street, New York, NY 10003, USA
Rheumatology (Oxford) 41:972-80. 2002
Destruction of articular joints occurs progressively in patients with rheumatoid arthritis (RA)...
- Adaptive control of stiffness to stabilize hand position with large loads
David W Franklin
School of Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
Exp Brain Res 152:211-20. 2003
..This did not occur when the joint stiffness coefficients were modeled as varying with the net torque at both joints, as in the present study...
- Anti-arthritic effect of GN1, a novel synthetic analog of glucosamine, in the collagen-induced arthritis model in rats
Pharmacology Unit, Lab 314, H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Inflamm Res 60:1113-20. 2011
..g., β-D-glucosamine, to combat rheumatoid arthritis, and tested its anti-arthritic effects in the collagen-induced arthritis (CIA) model in rats...
- A six degrees-of-freedom marker set for gait analysis: repeatability and comparison with a modified Helen Hayes set
Thomas D Collins
Gait Laboratory, Douglas Bader Rehabilitation Centre, Queen Mary s Hospital, London SW15 5PN, UK
Gait Posture 30:173-80. 2009
..The 6DOF set showed comparable performance to the conventional set and overcomes a number of theoretical limitations, however further development is needed prior to clinical implementation...
- Physical disability in rheumatoid arthritis is associated with cartilage damage rather than bone destruction
Department of Internal Medicine 3, Division of Rheumatology, Medical University Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
Ann Rheum Dis 70:733-9. 2011
..It is currently unclear to which extent these components affect irreversible functional disability. The aim of the present work was to determine these contributions...
- Age effects on the inter-joint coordination during obstacle-crossing
Hsiao Ching Yen
Institute of Biomedical Engineering, National Taiwan University, Taiwan
J Biomech 42:2501-6. 2009
..to the increased toe-clearance, indicates that aging increases the variability of the way the lower limb joints are controlled during obstacle-crossing...
- Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo
ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
Arthritis Rheum 60:1998-2007. 2009
..The aim of this study was to investigate the impact of osteoblast-targeted disruption of GC signaling on joint inflammation, cartilage damage, and bone metabolism in the K/BxN mouse serum transfer model of autoimmune arthritis...
- Development of synovial joints
Charles W Archer
School of Biosciences, Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Museum Avenue, Cardiff, CF1 3US, UK
Birth Defects Res C Embryo Today 69:144-55. 2003
Synovial joints arise through two main processes. In long bone elements, cartilaginous differentiation occurs across the locations of the prospective joints that then segment secondarily...
- The KRN mouse model of inflammatory arthritis
Department of Rheumatology, University Hospital of Zurich, Gloriastrasse 25, 8091, Zurich, Switzerland
Springer Semin Immunopathol 25:79-90. 2003
..Because of the reliable and robust induction of joint inflammation by serum transfer this new disease model has been and will be a valuable means to address the as-yet-unanswered key questions related to the development of arthritis...
- Efficacy and safety of repeat courses of rituximab treatment in patients with severe refractory juvenile idiopathic arthritis
Ekaterina I Alexeeva
Rheumatology Department, Scientific Center for Children s Health, Russian Academy of Medical Sciences, 2 62 Lomonosovsky Avenue, Moscow, Russia
Clin Rheumatol 30:1163-72. 2011
..This study supports the efficacy of rituximab in patients with severe forms of JIA, refractory to several prior agents...
- Characteristics of sensory DRG neurons innervating the lumbar facet joints in rats
Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Eur Spine J 14:559-64. 2005
..Neurons innervating the L5/6 facet joints, retrogradely-labeled with fluoro-gold (FG), were distributed throughout DRGs from L1 to L5...
- SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
Peter K K Wong
Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Clin Invest 116:1571-81. 2006
..These findings provide direct in vivo evidence that endogenous SOCS-3 is a critical negative regulator of multiple cell types orchestrating inflammatory joint disease...
- Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA)
Suvimol Chirathivat Hill
Diagnostic Radiology, Warren G Magnuson Clinical Center, National Institutes of Health, 10 Center Drive, Rm N242, Bethesda, MD 20892, USA
Pediatr Radiol 37:145-52. 2007
..Approximately 60% of NOMID patients have prominent arthropathy, most commonly involving the knees, the cause of which remains poorly understood...