Top Publications

  1. ncbi Mast cells: a cellular link between autoantibodies and inflammatory arthritis
    David M Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 297:1689-92. 2002
  2. ncbi Musculoskeletal ultrasound including definitions for ultrasonographic pathology
    Richard J Wakefield
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    J Rheumatol 32:2485-7. 2005
  3. ncbi ISB recommendation on definitions of joint coordinate systems of various joints for the reporting of human joint motion--Part II: shoulder, elbow, wrist and hand
    Ge Wu
    Department of Physical Therapy, University of Vermont, 305 Rathwell Building, Burlington, VT, USA
    J Biomech 38:981-992. 2005
  4. ncbi Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structu
    Joel M Kremer
    Albany Medical College and Center for Rheumatology, Albany, New York 12206, USA
    Arthritis Rheum 63:609-21. 2011
  5. pmc Evidence that cytokines play a role in rheumatoid arthritis
    Fionula M Brennan
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    J Clin Invest 118:3537-45. 2008
  6. ncbi ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion--part I: ankle, hip, and spine. International Society of Biomechanics
    Ge Wu
    J Biomech 35:543-8. 2002
  7. ncbi A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
    Velandai K Srikanth
    The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
    Osteoarthritis Cartilage 13:769-81. 2005
  8. ncbi Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial
    Björn Svensson
    University of Lund, Lund, Sweden
    Arthritis Rheum 52:3360-70. 2005
  9. ncbi A simplified disease activity index for rheumatoid arthritis for use in clinical practice
    J S Smolen
    University of Vienna and Lainz Hospital, Austria
    Rheumatology (Oxford) 42:244-57. 2003
  10. ncbi The uncontrolled manifold concept: identifying control variables for a functional task
    J P Scholz
    Physical Therapy Department, McKinly Laboratory, University of Delaware, Newark 19716, USA
    Exp Brain Res 126:289-306. 1999

Detail Information

Publications312 found, 100 shown here

  1. ncbi Mast cells: a cellular link between autoantibodies and inflammatory arthritis
    David M Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 297:1689-92. 2002
    ..Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis...
  2. ncbi Musculoskeletal ultrasound including definitions for ultrasonographic pathology
    Richard J Wakefield
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    J Rheumatol 32:2485-7. 2005
    ..advantages over magnetic resonance imaging, including good patient tolerability and ability to scan multiple joints in a short period of time...
  3. ncbi ISB recommendation on definitions of joint coordinate systems of various joints for the reporting of human joint motion--Part II: shoulder, elbow, wrist and hand
    Ge Wu
    Department of Physical Therapy, University of Vermont, 305 Rathwell Building, Burlington, VT, USA
    J Biomech 38:981-992. 2005
    ..Adopting these standards will lead to better communication among researchers and clinicians...
  4. ncbi Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structu
    Joel M Kremer
    Albany Medical College and Center for Rheumatology, Albany, New York 12206, USA
    Arthritis Rheum 63:609-21. 2011
  5. pmc Evidence that cytokines play a role in rheumatoid arthritis
    Fionula M Brennan
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    J Clin Invest 118:3537-45. 2008
    A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA)...
  6. ncbi ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion--part I: ankle, hip, and spine. International Society of Biomechanics
    Ge Wu
    J Biomech 35:543-8. 2002
    ..In this communication, the STC proposes definitions of JCS for the ankle, hip, and spine. Definitions for other joints (such as shoulder, elbow, hand and wrist, temporomandibular joint (TMJ), and whole body) will be reported in later ..
  7. ncbi A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
    Velandai K Srikanth
    The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
    Osteoarthritis Cartilage 13:769-81. 2005
    ..To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity...
  8. ncbi Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial
    Björn Svensson
    University of Lund, Lund, Sweden
    Arthritis Rheum 52:3360-70. 2005
    ..To assess the efficacy of low-dose prednisolone on joint damage and disease activity in patients with early rheumatoid arthritis (RA)...
  9. ncbi A simplified disease activity index for rheumatoid arthritis for use in clinical practice
    J S Smolen
    University of Vienna and Lainz Hospital, Austria
    Rheumatology (Oxford) 42:244-57. 2003
    ..The objective of this study was to verify the usefulness of a simple disease activity index (SDAI) for rheumatoid arthritis (RA)...
  10. ncbi The uncontrolled manifold concept: identifying control variables for a functional task
    J P Scholz
    Physical Therapy Department, McKinly Laboratory, University of Delaware, Newark 19716, USA
    Exp Brain Res 126:289-306. 1999
    ..The horizontal head position and the position of the hand were controlled less stably, while vertical head position appears to be no more controlled than joint motions...
  11. pmc EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    B Combe
    Immuno Rhumatologie, Lapeyronie Hosp, Montpellier, France
    Ann Rheum Dis 66:34-45. 2007
    ..To formulate EULAR recommendations for the management of early arthritis...
  12. ncbi Rheumatoid arthritis progression mediated by activated synovial fibroblasts
    Elena Neumann
    Dept of Internal Medicine and Rheumatology, Justus Liebig University Giesen, Kerckhoff Klinik, Benekestr 2 8, D 61231 Bad Nauheim, Germany
    Trends Mol Med 16:458-68. 2010
    ..Here, we review new findings regarding RASF activation and their altered behavior that contribute to matrix destruction and inflammation as well as their potential to spread RA...
  13. ncbi Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis
    Yoshinaga Ito
    Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Arthritis Rheum 60:2294-303. 2009
    ..The involvement of IL-17-producing gamma/delta T cells in SKG mice with autoimmune arthritis and patients with rheumatoid arthritis (RA) was also investigated...
  14. ncbi Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression
    A K Brown
    Chapel Allerton Hospital, University of Leeds, Leeds, UK
    Arthritis Rheum 54:3761-73. 2006
    ..This questions the validity of current methods of assessing remission in RA. The purpose of this study was to test the hypothesis that modern joint imaging improves the accuracy of remission measurement in RA...
  15. ncbi Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
    L J Brunet
    Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720 3204, USA
    Science 280:1455-7. 1998
    ..Excess BMP activity in the absence of Noggin antagonism may enhance the recruitment of cells into cartilage, resulting in oversized growth plates; chondrocytes are also refractory to joint-inducing positional cues...
  16. ncbi Disconnect between inflammation and joint destruction after treatment with etanercept plus methotrexate: results from the trial of etanercept and methotrexate with radiographic and patient outcomes
    Robert Landewe
    University Hospital Maastricht, Maastricht, The Netherlands
    Arthritis Rheum 54:3119-25. 2006
  17. ncbi Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
    P E Lipsky
    University of Texas Southwestern Medical Center at Dallas, USA
    N Engl J Med 343:1594-602. 2000
    ..However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are not known...
  18. pmc Whole limb kinematics are preferentially conserved over individual joint kinematics after peripheral nerve injury
    Young Hui Chang
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Biol 212:3511-21. 2009
    ..This may represent a fundamental compensation principle allowing animals to adapt to changing conditions with minimal effect on overall locomotor function...
  19. ncbi Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression
    Esperanza Naredo
    Hospital Severo Ochoa, Madrid, Spain
    Arthritis Rheum 57:116-24. 2007
  20. pmc A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis
    Brian Astry
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Interferon Cytokine Res 31:927-40. 2011
    ..important role in the pathogenesis of rheumatoid arthritis (RA), an autoimmune disease that targets the synovial joints. The cytokine environment in the peripheral lymphoid tissues and the target organ (the joint) has a strong ..
  21. pmc Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences
    Qilong Xu
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Mol Microbiol 69:15-29. 2008
    ..Taken together, the study demonstrated that the surface lipoproteins provide B. burgdorferi with an essential protective function against host innate elimination...
  22. ncbi Tri-dimensional and triphasic muscle organization of whole-body pointing movements
    E Chiovetto
    Italian Institute of Technology, Via Morego 30, 16163 Genoa, Italy
    Neuroscience 170:1223-38. 2010
    ..In particular, those associated with the muscles of the lower-body joints (ankle, knee and hip) always presented the three sequences in all conditions...
  23. ncbi EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis
    Alexandra N Colebatch
    Department of Rheumatology, University Hospital Southampton, Southampton, UK
    Ann Rheum Dis 72:804-14. 2013
    To develop evidence-based recommendations on the use of imaging of the joints in the clinical management of rheumatoid arthritis (RA).
  24. ncbi Production of canine mesenchymal stem cells from adipose tissue and their application in dogs with chronic osteoarthritis of the humeroradial joints
    Annalisa Guercio
    Area Diagnostica Virologica dellIstituto Zooprofilattico Sperimentale della Sicilia A Mirri, Palermo, Italy
    Cell Biol Int 36:189-94. 2012
    ..injection of AD-MSCs was evaluated on 4 dogs with lameness associated with OA (osteoarthritis) of the humeroradial joints. MSCs were readily isolated from adult dog adipose tissue, and their ability to form colony and differentiate into ..
  25. ncbi Power Doppler ultrasound, but not low-field magnetic resonance imaging, predicts relapse and radiographic disease progression in rheumatoid arthritis patients with low levels of disease activity
    Violaine Foltz
    University of Paris VI and Rheumatology Department, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Arthritis Rheum 64:67-76. 2012
    ..The aim of this study was to compare the ability of ultrasonography and magnetic resonance imaging (MRI) to predict relapse and radiographic progression in these patients...
  26. pmc EMG-based simultaneous and proportional estimation of wrist/hand kinematics in uni-lateral trans-radial amputees
    Ning Jiang
    Strategic Technology Management, OttoBock HealthCare GmbH, Max Näder Str 15, Duderstadt, 37115, Germany
    J Neuroeng Rehabil 9:42. 2012
    ..The results from the current study demonstrated the feasibility of the proposed myoelectric control approach to provide a more intuitive myoelectric control strategy for unilateral transradial amputees...
  27. pmc Kinematics of gait: new method for angle estimation based on accelerometers
    Milica D Djurić-Jovičić
    School of Electrical Engineering, University of Belgrade, Bulevar kralja Aleksandra 73, Belgrade, Serbia
    Sensors (Basel) 11:10571-85. 2011
    A new method for estimation of angles of leg segments and joints, which uses accelerometer arrays attached to body segments, is described. An array consists of two accelerometers mounted on a rigid rod...
  28. ncbi Unloading joints to treat osteoarthritis, including joint distraction
    Floris P J G Lafeber
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands
    Curr Opin Rheumatol 18:519-25. 2006
    ..This review examines the recent literature on the potential beneficial effects of unloading joints in the treatment of osteoarthritis, with a focus on joint distraction.
  29. ncbi Is osteoarthritis a systemic disorder of bone?
    Juliet Rogers
    University of East Anglia, Norwich, UK
    Arthritis Rheum 50:452-7. 2004
    To describe the osteologic findings associated with osteoarthritis (OA) of a variety of joints.
  30. ncbi Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    Erik Lubberts
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:650-9. 2004
    ..This T cell cytokine is implicated in the initiation phase of arthritis. However, the role of IL-17 during the effector phase of arthritis has still not been identified; this was the objective of the present study...
  31. ncbi Enhancement of collagen-induced arthritis in mice genetically deficient in extracellular superoxide dismutase
    Aron D Ross
    National Jewish Medical and Research Center, Denver, Colorado, USA
    Arthritis Rheum 50:3702-11. 2004
    ..To examine the influence of superoxide on the severity of collagen-induced arthritis (CIA) in mice...
  32. pmc The kinaesthetic senses
    Uwe Proske
    Department of Physiology, PO Box 13F, Monash University, Clayton, Victoria 3800, Australia
    J Physiol 587:4139-46. 2009
    ..Joint receptors do not appear to play a major role at most joints. The evidence supports the existence of two separate senses, the sense of limb position and the sense of limb ..
  33. ncbi Physiological characteristics of low-threshold mechanoreceptors in joints, muscle and skin in human subjects
    Vaughan G Macefield
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 32:135-44. 2005
    ..detailed analyses of the signalling capacities of single mechanoreceptive afferents from the skin, muscles and joints. For example, we know much about how the two classes of rapidly adapting (Meissner and Pacinian) and two classes ..
  34. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  35. ncbi A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis
    A H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Centre, PO Box 9600, 2300RC Leiden, The Netherlands
    Ann Rheum Dis 67:769-74. 2008
    ..Rheumatoid arthritis (RA) is marked by the presence of proinflammatory cytokines and, in general, the presence of high levels of inflammatory markers is associated with a severe disease course and joint damage...
  36. ncbi A 78-joints ultrasonographic assessment is associated with clinical assessments and is highly responsive to improvement in a longitudinal study of patients with rheumatoid arthritis starting adalimumab treatment
    Hilde Berner Hammer
    Department of Rheumatology, Diakonhjemmet Hospital, Box 23, Vinderen, N 0319 Oslo, Norway
    Ann Rheum Dis 69:1349-51. 2010
    ..associations between ultrasonography (US) assessments (B-mode (BM) and power Doppler (PD)) of a large number of joints and traditional assessments of disease activity, and to examine the sensitivity to change of the US scores and ..
  37. ncbi Mobility of the pelvic joints in pregnancy-related lumbopelvic pain: a systematic review
    Jan M A Mens
    Institute of Rehabilitation Medicine, Department of Neuroscience, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Obstet Gynecol Surv 64:200-8. 2009
    ..It has been suggested that increased motion of the three joints in the pelvic ring is one of the causes of PLPP...
  38. ncbi Efficient management of rheumatoid arthritis significantly reduces long-term functional disability
    E Tanaka
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Ann Rheum Dis 67:1153-8. 2008
    ..The aim of this study was to examine the effect of efficient management of rheumatoid arthritis (RA) in relation to disability levels in a large cohort of patients with RA over a period of 3 years...
  39. ncbi An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents
    Mark C Genovese
    Division of Immunology and Rheumatology, Stanford University, Palo Alto, California, USA
    Arthritis Rheum 63:337-45. 2011
    ..To assess the efficacy and safety of R788 (fostamatinib disodium), an inhibitor of spleen tyrosine kinase (Syk), in patients with active rheumatoid arthritis (RA) that did not respond to biologic therapies...
  40. ncbi Classification of rheumatoid arthritis: comparison of the 1987 American College of Rheumatology criteria and the 2010 American College of Rheumatology/European League Against Rheumatism criteria
    M P M van der Linden
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 63:37-42. 2011
  41. ncbi Action and perception at the level of synergies
    M T Turvey
    Center for the Ecological Study of Perception and Action, University of Connecticut, Storrs, CT, USA
    Hum Mov Sci 26:657-97. 2007
    ..Coverage is given to symmetry groups, task space, order parameters, metastability, biotensegrity, allometric scaling, and impredicative definitions...
  42. ncbi Estimation and visualization of sagittal kinematics of lower limbs orientation using body-fixed sensors
    Hooman Dejnabadi
    Ecole Polytechnique Federale de Lausanne EPFL, Laboratory of Movement Analysis and Measurement, 1015 Lausanne, Switzerland
    IEEE Trans Biomed Eng 53:1385-93. 2006
    ..The model is based on estimating the accelerations of ankle and knee joints by placing virtual sensors at the centers of rotation...
  43. ncbi Control and estimation of posture during quiet stance depends on multijoint coordination
    Wei Li Hsu
    Dept of Physical Therapy, Biomechanics and Movement Science Program, 307 McKinly Laboratory, University of Delaware, Newark, DE 19716, USA
    J Neurophysiol 97:3024-35. 2007
    This study tested the hypotheses that all major joints along the longitudinal axis of the body are equally active during quiet standing and that their motions are coordinated to stabilize the spatial positions of the center of mass (CM) ..
  44. ncbi Less radiographic progression with adalimumab plus methotrexate versus methotrexate monotherapy across the spectrum of clinical response in early rheumatoid arthritis
    Paul Emery
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, United Kingdom
    J Rheumatol 36:1429-41. 2009
    ..To determine the relationship between radiographic progression and clinical response for adalimumab plus methotrexate (MTX) versus either monotherapy in patients with early rheumatoid arthritis (RA) in the PREMIER study...
  45. ncbi Deletion of either CD55 or CD97 ameliorates arthritis in mouse models
    Robert M Hoek
    Academic Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 62:1036-42. 2010
    ..This study was undertaken to investigate the role of CD55 in experimental RA...
  46. pmc The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
    David K Rhee
    Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Invest 115:622-31. 2005
    ..In order to delineate the mechanism by which lubricin protects joints, we studied the expression of Prg4 mRNA during mouse joint development, and we created lubricin-mutant mice...
  47. ncbi Temporal analysis of pathogenic events in virulent and avirulent Brucella melitensis infections
    Gireesh Rajashekara
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, 53706, USA
    Cell Microbiol 7:1459-73. 2005
    ..Sublethal infection of IRF-1(-/-) mice resulted in chronic Brucella localization in tail joints, an infection parallel to osteoarticular brucellosis in humans...
  48. pmc Retrospective clinical study on the notable efficacy and related factors of infliximab therapy in a rheumatoid arthritis management group in Japan: one-year clinical outcomes (RECONFIRM-2)
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Mod Rheumatol 18:146-52. 2008
    ..2%, respectively. In conclusion, we reconfirmed the clinical efficacy of infliximab and demographic factors related to the efficacy over a 54-week study period in 410 Japanese patients with RA using DAS28-CRP and EULAR response criteria...
  49. pmc Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferi
    Yanlin Shi
    Department of Pathobiological Sciences, Louisiana State University, Skip Bertman Drive at River Road, Baton Rouge, LA 70803, USA
    Infect Immun 76:1239-46. 2008
    ..Taken together, the study results indicate that neither DbpA nor DbpB is essential for mammalian infection but that both are critical for the overall virulence of B. burgdorferi...
  50. ncbi Genetic variation and genetic trends in hip and elbow dysplasia in Swedish Rottweiler and Bernese Mountain Dog
    S Malm
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Anim Breed Genet 125:403-12. 2008
    ..Based on the results, a statistical model for routine prediction of breeding values for HD and ED in Swedish dogs was suggested...
  51. pmc Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family
    N M Wolfman
    Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
    J Clin Invest 100:321-30. 1997
    ..In addition, comparative in situ localizations of the GDF-5, 6, and 7 mRNAs suggest that these molecules are important regulatory components of synovial joint morphogenesis...
  52. ncbi Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation
    Kingston Kinglun Mak
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Development 133:3695-707. 2006
    ..However, there is a strong synergistic interaction between Wnt/beta-catenin and Ihh signaling in regulating synovial joint formation...
  53. ncbi Osteoarthritis cartilage histopathology: grading and staging
    K P H Pritzker
    Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Osteoarthritis Cartilage 14:13-29. 2006
    ..Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method...
  54. ncbi Pathophysiology of spastic paresis. II: Emergence of muscle overactivity
    Jean Michel Gracies
    Department of Neurology, Mount Sinai Medical Center, One Gustave L Levy Place, Annenberg 2 Box 1052, New York, New York 10029 6574, USA
    Muscle Nerve 31:552-71. 2005 symmetrically distributed between agonists and antagonists, which generates torque imbalance around joints and limb deformities. Thus, each may be best treated focally on an individual muscle-by-muscle basis...
  55. ncbi Efficacy of etanercept for the treatment of juvenile idiopathic arthritis according to the onset type
    Pierre Quartier
    Hopital Necker Enfants Malades, Paris, France
    Arthritis Rheum 48:1093-101. 2003
    ..To assess the efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA), and to assess the tolerance of these patients to etanercept...
  56. pmc Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan: results from a retrospective study (REACTION study)
    Hisashi Yamanaka
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 21:122-33. 2011
    ..Tocilizumab infusion is therefore applicable not only as an alternative approach for anti-TNF therapy-resistant patients, but also as primary biologic therapy for active RA patients...
  57. ncbi Effect of fluid boundary conditions on joint contact mechanics and applications to the modeling of osteoarthritic joints
    Salvatore Federico
    Dipartimento di Ingegneria Industriale e Meccanica, Facolta di Ingegneria, Universita degli Studi di Catania, Catania, Italy
    J Biomech Eng 126:220-5. 2004
    ..These findings agree well with experimental observations...
  58. ncbi Lubrication at physiological pressures by polyzwitterionic brushes
    Meng Chen
    Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford OX1 3QZ, UK
    Science 323:1698-701. 2009
    The very low sliding friction at natural synovial joints, which have friction coefficients of mu < 0...
  59. ncbi Reaching to grasp with a multi-jointed arm. I. Computational model
    Elizabeth B Torres
    Division of Biology, California Institute of Technology, Pasadena 91125, California, USA
    J Neurophysiol 88:2355-67. 2002
    ..Simulated orientation-matching movements are compared with actual human movement data to assess the validity of several of the model's behavioral predictions...
  60. pmc Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton
    Susan Skuntz
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3706, USA
    Dev Biol 332:383-95. 2009
    ..A prominent and consistent phenotype of these mutations is a remodeling of the cranio-cervical joints whose major feature is the assimilation of the atlas into the basioccipital bone so that the skull rests on the ..
  61. ncbi Collagen morphology in human skin and scar tissue: no adaptations in response to mechanical loading at joints
    Paul P M van Zuijlen
    Burn Centre and Department of Surgery, Red Cross Hospital, Vondellaan 13, 1942 LE Beverwijk, The Netherlands
    Burns 29:423-31. 2003
    ..mechanical tension during scarring, which may explain the problematic scar formation that occurs specifically at joints. Scar tissue and normal skin were biopsied from joints and control areas and evaluated by the Fourier analysis...
  62. ncbi Denosumab for joints and bones
    E Michael Lewiecki
    New Mexico Clinical Research and Osteoporosis Center, 300 Oak Street NE, Albuquerque, NM 87106, USA
    Curr Rheumatol Rep 11:196-201. 2009
    ..It is generally well tolerated, with a good safety profile. Adverse and serious adverse events, including infections and malignancy, are similar in patients treated with denosumab or placebo...
  63. ncbi Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 production
    Jun Akaogi
    University of Florida, P O Box 100221, Gainesville, FL 32610 0221, USA
    J Leukoc Biol 76:227-36. 2004
    ..PGE(2) can modulate inflammatory reactions via the EP2/4 receptor through its regulation of TNF-alpha and IL-6. Modification of EP signaling may be a new therapeutic strategy in inflammatory/autoimmune diseases...
  64. pmc The differential expressions of 78-kDa glucose-regulated protein of infiltrating plasma cells in peripheral joints with the histopathological variants of rheumatoid synovitis
    Weijia Dong
    Department of Clinical Immunology, State Key Discipline of Cell Biology, Xijing Hospital, Fourth Military Medical University, 17 Changlexi Street, Xi an 710032, Shaanxi, PR China
    Arthritis Res Ther 11:R4. 2009
    ..explore the potential links between the activation of the UPR of infiltrating plasma cells in inflamed peripheral joints and the histopathological variants of rheumatoid synovitis as well as the local production of pathogenic ..
  65. ncbi Reproducibility of joint swelling assessments in long-lasting rheumatoid arthritis: influence on Disease Activity Score-28 values (SEA-Repro study part I)
    Thierry Marhadour
    Rheumatology Unit, CHU, and University Hospital La Cavale Blanche, Brest, France
    J Rheumatol 37:932-7. 2010
    ..To evaluate the reproducibility of clinical synovitis assessments in rheumatoid arthritis and the effect of variability on the Disease Activity Score-28 (DAS28)...
  66. ncbi Activated memory B cells may function as antigen-presenting cells in the joints of children with juvenile idiopathic arthritis
    Henner Morbach
    Vivantes Children s Hospital, Berlin Friedrichshain, Germany Children s Hospital and University of Würzburg, Wurzburg, Germany
    Arthritis Rheum 63:3458-66. 2011
    ..This study was undertaken to investigate whether synovial B cells in patients with juvenile idiopathic arthritis (JIA) might display features of APCs...
  67. pmc scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints
    R S Watson
    Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL 32608 0137, USA
    Gene Ther 20:670-7. 2013
    ..the equine joint as a model for adeno-associated virus (AAV)-mediated gene transfer to large, weight-bearing human joints. A self-complementary AAV2 vector containing the coding regions for human interleukin-1-receptor antagonist (hIL-..
  68. ncbi Joint damage in rheumatoid arthritis progresses in remission according to the Disease Activity Score in 28 joints and is driven by residual swollen joints
    Daniel Aletaha
    Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Arthritis Rheum 63:3702-11. 2011
    ..The Disease Activity Score in 28 joints (DAS28) has been criticized for the amount of disease activity that remains in patients despite their achieving ..
  69. pmc Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis
    Ulrika Islander
    Centre for Bone and Arthritis Research, The Sahlgrenska Academy, University of Gothenburg, Box 480, 405 30 Gothenburg, Sweden
    Arthritis Res Ther 13:R96. 2011
  70. ncbi Therapeutic effects of TACI-Ig on rats with adjuvant-induced arthritis via attenuating inflammatory responses
    Yan Chang
    Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti inflammatory and Immunopharmacology of Education Ministry of China, Hefei 230032, PR China
    Rheumatology (Oxford) 50:862-70. 2011
  71. pmc Patient-cooperative control increases active participation of individuals with SCI during robot-aided gait training
    Alexander Duschau-Wicke
    Sensory Motor Systems Lab, Institute of Robotics and Intelligent Systems, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland
    J Neuroeng Rehabil 7:43. 2010
    ..In this study, we have investigated the immediate effects of patient-cooperative versus non-cooperative robot-aided gait training on individuals with incomplete spinal cord injury (iSCI)...
  72. ncbi The internal model and the leading joint hypothesis: implications for control of multi-joint movements
    Natalia Dounskaia
    Department of Kinesiology, Arizona State University, P O Box 870404, Tempe, AZ 85287 0404, USA
    Exp Brain Res 166:1-16. 2005
  73. ncbi Osteosarcoma near joints: assessment and implications
    Gerald M Y Quan
    Department of Orthopaedics, St Vincent s Hospital, Melbourne, Australia
    J Surg Oncol 91:159-66. 2005
    The choice of performing surgery when tumors encroach onto joints remains a challenging and controversial issue...
  74. ncbi Shape of articular surface of crocodilian (Archosauria) elbow joints and its relevance to sauropsids
    Shin ichi Fujiwara
    The University Museum, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Morphol 271:883-96. 2010
    ..This study aims at describing the shape of the articular cartilages in the elbow joints of six crocodilian specimens; comparing its structure with that of four birds, three testudines, and five ..
  75. pmc Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints
    Jun Pan
    Key Laboratory for Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, PR China
    Bone 51:212-7. 2012
    ..We previously detected measurable transport of solute across the mineralized calcified cartilage in normal joints, suggesting a potential cross-talk between subchondral bone and cartilage...
  76. ncbi IL-27-producing CD14(+) cells infiltrate inflamed joints of rheumatoid arthritis and regulate inflammation and chemotactic migration
    Shimei Tanida
    Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Cytokine 55:237-44. 2011
    ..However, the origin and effects of IL-27 in joints of rheumatoid arthritis (RA) remain unclear...
  77. pmc Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort
    Wonuk Lee
    Division of Rheumatology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Ann Rheum Dis 66:633-8. 2007
  78. pmc The ability of synovitis to predict structural damage in rheumatoid arthritis: a comparative study between clinical examination and ultrasound
    Maxime Dougados
    Hopital Cochin, Rheumatology, Clinique de Rhumatologie B, Groupe Hospitalier Cochin, Paris 75014, France
    Ann Rheum Dis 72:665-71. 2013
    ..To evaluate synovitis (clinical vs ultrasound (US)) to predict structural progression in rheumatoid arthritis (RA)...
  79. ncbi American College of Rheumatology provisional criteria for defining clinical inactive disease in select categories of juvenile idiopathic arthritis
    Carol A Wallace
    Seattle Children s Hospital and University of Washington School of Medicine, Seattle
    Arthritis Care Res (Hoboken) 63:929-36. 2011
    ..To prospectively validate the preliminary criteria for clinical inactive disease (CID) in patients with select categories of juvenile idiopathic arthritis (JIA)...
  80. pmc Potential role of fibroblast-like synoviocytes in joint damage induced by Brucella abortus infection through production and induction of matrix metalloproteinases
    Romina Scian
    IDEHU, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956 4to piso, 1113 Buenos Aires, Argentina
    Infect Immun 79:3619-32. 2011
    ..These results suggest that FLS, and phagocytes recruited by them to the infection focus, may be involved in joint damage during brucellar arthritis through the production of MMPs and proinflammatory mediators...
  81. pmc Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis
    Yuji Yamanishi
    University of California at San Diego School of Medicine, La Jolla La Jolla, California 92093, USA
    Am J Pathol 160:123-30. 2002
    ..In contrast, the joints of p53(-/-) DBA/1 animals with CIA showed increased severity of arthritis using clinical and histological scoring ..
  82. ncbi Inflammatory joint manifestations are prevalent in psoriasis: prevalence study of joint and axial involvement in psoriatic patients, and evaluation of a psoriatic and arthritic questionnaire
    Gerd Marie Alenius
    Division of Rheumatology, University Hospital, Umea, Sweden
    J Rheumatol 29:2577-82. 2002
    ..the question "Have you ever thought you might have arthritis?" in combination with morning stiffness in peripheral joints for at least 60 min, had a sensitivity of 30% and a specificity of 91...
  83. ncbi Normal and prosthetic synovial joints are lubricated by surface-active phospholipid: a hypothesis
    B A Hills
    Mater Children s Hospital and Department of Medicine university of Queensland, Queensland University ot Technology, Brisbane, Australia
    J Arthroplasty 18:499-505. 2003
    ..This, in turn, leads to the replenishment of SAPL, as tested in OA, and the concept of prelubricating prostheses before implantation...
  84. ncbi Candidate early predictors for progression to joint damage in systemic juvenile idiopathic arthritis
    Christy Sandborg
    Department of Pediatrics, Stanford University School of Medicine, University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
    J Rheumatol 33:2322-9. 2006
    ..To assess if joint damage at 2 years after diagnosis in patients with systemic juvenile idiopathic arthritis (SJIA) can be predicted by clinical or laboratory features assessed up to 3 or 6 months after diagnosis...
  85. ncbi Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice
    Arpád Szabó
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs 7624, Szigeti u 12, Hungary
    J Pharmacol Exp Ther 314:111-9. 2005
    ..Histological examination and scoring of the tibiotarsal joints revealed marked arthritic changes in wild-type mice...
  86. ncbi The effects of oral glucosamine on joint health: is a change in research approach needed?
    J A Block
    Department of Internal Medicine Rheumatology, Rush University Medical Center, Chicago IL 60612, USA
    Osteoarthritis Cartilage 18:5-11. 2010
    ..Here, we review the state of knowledge concerning the biology of GlcN as it relates to OA, and discuss a framework for future research directions...
  87. ncbi Galanin influences the mechanosensitivity of sensory endings in the rat knee joint
    B Heppelmann
    Physiologisches Institut, Universitat Wurzburg, Röntgenring 9, D 97070 Wurzburg, Germany
    Eur J Neurosci 12:1567-72. 2000
    ..effect of galanin on group III and IV afferent nerve fibres (n = 53) innervating normal and acutely inflamed knee joints in rats. They responded to local mechanical stimulation, movements of the joint and i.a...
  88. ncbi The role of the lumbar facet joints in spinal stability. Identification of alternative paths of loading
    T R Haher
    Department of Orthopaedics, SUNY HSC at Brooklyn
    Spine (Phila Pa 1976) 19:2667-70 discussion 2671. 1994
    STUDY DESIGN. The role of the facet joints in spinal stability was analyzed using long-segment cadaver spines. OBJECTIVES. To establish the existence of alternate paths of loading when the facet joints and anulus are compromised...
  89. ncbi Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage
    S B Abramson
    Department of Rheumatology, Hospital for Joint Diseases, New York University of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Rheumatology (Oxford) 41:972-80. 2002
    Destruction of articular joints occurs progressively in patients with rheumatoid arthritis (RA)...
  90. ncbi Adaptive control of stiffness to stabilize hand position with large loads
    David W Franklin
    School of Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
    Exp Brain Res 152:211-20. 2003
    ..This did not occur when the joint stiffness coefficients were modeled as varying with the net torque at both joints, as in the present study...
  91. ncbi Anti-arthritic effect of GN1, a novel synthetic analog of glucosamine, in the collagen-induced arthritis model in rats
    Huma Jawed
    Pharmacology Unit, Lab 314, H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Inflamm Res 60:1113-20. 2011
    ..g., β-D-glucosamine, to combat rheumatoid arthritis, and tested its anti-arthritic effects in the collagen-induced arthritis (CIA) model in rats...
  92. ncbi A six degrees-of-freedom marker set for gait analysis: repeatability and comparison with a modified Helen Hayes set
    Thomas D Collins
    Gait Laboratory, Douglas Bader Rehabilitation Centre, Queen Mary s Hospital, London SW15 5PN, UK
    Gait Posture 30:173-80. 2009
    ..The 6DOF set showed comparable performance to the conventional set and overcomes a number of theoretical limitations, however further development is needed prior to clinical implementation...
  93. ncbi Physical disability in rheumatoid arthritis is associated with cartilage damage rather than bone destruction
    Daniel Aletaha
    Department of Internal Medicine 3, Division of Rheumatology, Medical University Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Ann Rheum Dis 70:733-9. 2011
    ..It is currently unclear to which extent these components affect irreversible functional disability. The aim of the present work was to determine these contributions...
  94. ncbi Age effects on the inter-joint coordination during obstacle-crossing
    Hsiao Ching Yen
    Institute of Biomedical Engineering, National Taiwan University, Taiwan
    J Biomech 42:2501-6. 2009 the increased toe-clearance, indicates that aging increases the variability of the way the lower limb joints are controlled during obstacle-crossing...
  95. ncbi Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo
    Frank Buttgereit
    ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Arthritis Rheum 60:1998-2007. 2009
    ..The aim of this study was to investigate the impact of osteoblast-targeted disruption of GC signaling on joint inflammation, cartilage damage, and bone metabolism in the K/BxN mouse serum transfer model of autoimmune arthritis...
  96. ncbi Development of synovial joints
    Charles W Archer
    School of Biosciences, Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Museum Avenue, Cardiff, CF1 3US, UK
    Birth Defects Res C Embryo Today 69:144-55. 2003
    Synovial joints arise through two main processes. In long bone elements, cartilaginous differentiation occurs across the locations of the prospective joints that then segment secondarily...
  97. ncbi The KRN mouse model of inflammatory arthritis
    Diego Kyburz
    Department of Rheumatology, University Hospital of Zurich, Gloriastrasse 25, 8091, Zurich, Switzerland
    Springer Semin Immunopathol 25:79-90. 2003
    ..Because of the reliable and robust induction of joint inflammation by serum transfer this new disease model has been and will be a valuable means to address the as-yet-unanswered key questions related to the development of arthritis...
  98. ncbi Efficacy and safety of repeat courses of rituximab treatment in patients with severe refractory juvenile idiopathic arthritis
    Ekaterina I Alexeeva
    Rheumatology Department, Scientific Center for Children s Health, Russian Academy of Medical Sciences, 2 62 Lomonosovsky Avenue, Moscow, Russia
    Clin Rheumatol 30:1163-72. 2011
    ..This study supports the efficacy of rituximab in patients with severe forms of JIA, refractory to several prior agents...
  99. pmc Characteristics of sensory DRG neurons innervating the lumbar facet joints in rats
    Tetsuhiro Ishikawa
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Eur Spine J 14:559-64. 2005
    ..Neurons innervating the L5/6 facet joints, retrogradely-labeled with fluoro-gold (FG), were distributed throughout DRGs from L1 to L5...
  100. pmc SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
    Peter K K Wong
    Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Clin Invest 116:1571-81. 2006
    ..These findings provide direct in vivo evidence that endogenous SOCS-3 is a critical negative regulator of multiple cell types orchestrating inflammatory joint disease...
  101. ncbi Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA)
    Suvimol Chirathivat Hill
    Diagnostic Radiology, Warren G Magnuson Clinical Center, National Institutes of Health, 10 Center Drive, Rm N242, Bethesda, MD 20892, USA
    Pediatr Radiol 37:145-52. 2007
    ..Approximately 60% of NOMID patients have prominent arthropathy, most commonly involving the knees, the cause of which remains poorly understood...

Research Grants77

    Keri Hammel; Fiscal Year: 2013
    ..BD), a chronic inflammatory disorder that can affect the eye, mucous membranes, and other body organs such as the joints, intestinal tract, blood vessels, and central nervous system...
    Keri Hammel; Fiscal Year: 2012
    ..BD), a chronic inflammatory disorder that can affect the eye, mucous membranes, and other body organs such as the joints, intestinal tract, blood vessels, and central nervous system...
  3. Identification of Genetic and Epigenetic Alterations in Spondyloarthritis
    Tibor T Glant; Fiscal Year: 2013
    ..ligament and tendon attachments (enthesitis) and is frequently associated with inflammation of the peripheral joints. Also, AS is often associated with extra-skeletal manifestations such as anterior uveitis and inflammatory bowel ..
  4. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Psoriasis is a disease with flakey skin, and can be associated with arthritis of joints of hands, wrist, feet, ankle, knee, and spine...
  5. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..which further promotes wound healing without scar formation would also be of significant benefit since scars over joints can limit limb motion and can have a strong psychological impact...
  6. Autoimmunity Center of Excellence (ACE) at Stanford
    ..juvenile idiopathic arthritis (SJIA)] that afflict adults and children, as well as organ systems including joints, skin, blood elements, and blood vessels, and will both test efficacy of therapy and develop tests to characterize ..
  7. BBP (Bone Morphogenetic Protein Binding Peptide) and Bone Healing
    SAMUEL SCOTT MURRAY; Fiscal Year: 2013 enhance their activity and promote bone growth and the successful integration of bone grafts or artificial joints into the skeleton...
    Tibor T Glant; Fiscal Year: 2013
    ..arthritis (RA) as indicated by clinical assessments, laboratory tests, x-ray and histopathology of diarthrodial joints. Similar to RA, PGIA is a T cell-dependent and antibody/B cell-mediated autoimmune disease...
    Cornelia M Weyand; Fiscal Year: 2012
    ..that the immune system of RA patients has a principal defect and that the chronic inflammation destroying joints and other organs systems may signify diminished and not enhanced immune function...
  10. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
    ..stimulus from secreted cytokines increases osteoclast activity, erodes bone surfaces, and progressively destroys joints. Research advances have identified the mechanism of osteoclastogenesis and bone resorption, and provided new ..
  11. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..arthritis (RA), one of the most common human autoimmune diseases, primarily affects the synovial membranes of joints. CD4+ T cells are thought to play an essential role in the development of RA, where they are a predominant cell ..
  12. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2013
    ..If untreated, Lyme disease can lead to a wide array of complications typically involving the heart, joints, or nervous system. It is widely believed that the motility of B...
  13. The Role of Carboxypeptidase B and its Substrates in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2013
    ..Characteristic histologic features in RA joints are synovial hyperplasia, inflammatory cell infiltrates, bone erosions and fibrin deposits...
  14. Pathogenesis of autoimmune endocarditis: roles for Fc receptors and integrins?
    Bryce Binstadt; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Many systemic autoimmune diseases affect both the synovial joints and the cardiovascular system...
  15. Neural Representation of Reach-to-Grasp for Cortical FES Neuroprostheses
    Abidemi Bolu Ajiboye; Fiscal Year: 2012
    ..typically require SCI persons to retain some volitional movement such as contraction of muscles or movement of joints above the line of injury...
  16. Mechanical and Osmotic Signaling in Chondrocytes
    Farshid Guilak; Fiscal Year: 2013
    Osteoarthritis is a painful and debilitating disease of the synovial joints, affecting an estimated 21 million people in the United States...
  17. Humanized Transgenic Mice Reproduce the Disease Evolution in Severe RA
    Grete Sonderstrup; Fiscal Year: 2010
    ..By expressing, as a transgene, the human Class II transactivator, CIITA, in the synovial joints, it was found that mice attain a much higher sensitivity to develop inflammatory arthritis and this feature is ..
  18. High Throughput Screening of the Autoimmune Epitome
    Nancy J Olsen; Fiscal Year: 2010
    ..Challenge Area (04) Clinical Research and specific Challenge Topic 04-AR-101 Autoimmunity for Diseases of Skin, Joints, Muscles and Other Tissues...
  19. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2010
    ..heterozygous chondrodysplasia, cho/+) mice develop progressive OA-like changes in knee and temporomandibular (TM) joints;(2) the levels of expression and activity of matrix metalloproteinase 13 (MMP-13, collagenase 3), a major ..
  20. Foot Bone Motion in End Stage Ankle Arthritis Patients
    William R Ledoux; Fiscal Year: 2012
    ..e., pain), the patient is left with a fused ankle, which results in the distal foot joints (subtalar, midtarsal and tarsometatarsal) being stretched into increased dorsiflexion during the push off phase of ..
  21. Elucidating the JNK2-mediated redox regulation of cartilage matrix remdeling
    ..research will elucidate the role of reactive oxygen species in promoting cartilage breakdown in osteoarthritic joints. The results of these studies could help in the identification of potential therapeutic targets that can slow or ..
    Tariq M Haqqi; Fiscal Year: 2010
    ..OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips...
  23. Rocker Shoes for Natural Immobilization of the Ankle during Single Limb Support
    Andrew H Hansen; Fiscal Year: 2012 the ankle during single limb support (SLS) phase of walking, the period of highest compressive load on the joints. These rocker shoes lead to "natural immobilization" of the ankle joint because they provide a rocker shape that ..
    JOHN PATTERSON ATKINSON; Fiscal Year: 2013
    ..As we age, lipids deposit in blood vessel walls (atherosclerosis), urate in joints (gout), amyloid proteins in the brain (Alzheimer's disease - AD) and lipofuscin pigments (drusen) in the ..
  25. Clinical trial of self complementary AAV8-mediated gene transfer for hemophilia B
    Andrew M Davidoff; Fiscal Year: 2013
    ..Clinically the disease is characterized by frequent spontaneous bleeding, most commonly into such sites as joints and soft tissues, but which can also occur in the brain and potentially be life threatening...
  26. Inhibition of CCR1/CCR5 mediated angiogenesis and joint destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2010
    ..MIP-11)/CCL3 are the chemokines shown to activate CCR1 and CCR5 receptor to attract T cells and monocytes into joints during the onset of disease...
  27. Suppression of Collagen Induced Arthritis with Altered Peptide Ligands
    Andrew H Kang; Fiscal Year: 2010
    Rheumatoid arthritis is a chronic inflammatory disease of diarthrodial joints. This systemic disease is characterized by chronic synovitis, sustained by an antigen-driven immune process against one or more proteins found in cartilage...
  28. Regulation of IL-6 mediated inflammation and tissue destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is a chronic inflammatory disease of the articular joints. A systemic inflammatory milieu generated by high levels of pro-inflammatory cytokines, interleukin-6 (IL-6) in ..
    Tariq M Haqqi; Fiscal Year: 2011
    ..OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips...
  30. Developing small molecule therapeutics for lupus
    Thomas R Coleman; Fiscal Year: 2012
    ..erythematosus (SLE) affects ~ 2 million Americans with devastating impact on multiple organs, especially the skin, joints, kidney, and brain...
  31. Mechanisms of FGFR2 Signaling in Craniofacial Development
    Veraragavan P Eswarakumar; Fiscal Year: 2013
    ..The cranial sutures are specialized joints which contain rapidly dividing osteoprogenitors and mesenchymal cells...
  32. Obesity, Biomechanics, and Inflammation in Osteoarthritis
    Farshid Guilak; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoarthritis (OA) is a painful and debilitating disease of the synovial joints, affecting an estimated 27 million people in the United States...
  33. Muscle viscosity as a protective mechanism for absorbing mechanical shock
    Armen Sarvazyan; Fiscal Year: 2013
    ..The ability of muscle to redistribute the energy of mechanical shock in time and space and unload skeletal joints is of key importance in physical activities, such as running and jumping, playing soccer, wrestling, etc...
  34. Novel Therapies and Biomarkers for the Mucopolysaccharidoses
    CALOGERA MARIA SIMONARO; Fiscal Year: 2013
    ..Among the various organ systems involved, the bones and joints are severely affected...
  35. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
    ..throughout the body, our results will likely be directly applicable to many organ systems, including lung, bone, joints, and heart...
  36. BMP2 signaling of the development of osetoarthritis
    Vicki Rosen; Fiscal Year: 2013 necessary for initiating chondrogenesis during skeletal development and is required for formation of synovial joints (5-11). BMP signaling is also involved in the maintenance of functional synovial joints after birth (12)...
  37. Characterization of the NOD2 NBD domain and role in chronic inflammation
    Jae W Dugan; Fiscal Year: 2013
    ..graft- versus-host disease, leprosy and Blau syndrome (chronic granulomatous inflammation of the skin, eyes, and joints)...
  38. The Toll-like receptor pathway in Meniscal Injury and Osteoarthritis
    CARLA ROSE SCANZELLO; Fiscal Year: 2013
    ..We recently demonstrated that the pro-inflammatory cytokine interleukin-15 (IL-15) is detectable in the joints of most patients with knee OA seeking surgical intervention for both early and advanced disease7...
  39. High Throughput Screen for Novel Anti-Rheumatic Compounds
    Dale J Christensen; Fiscal Year: 2010
    ..RA) is a chronic, systemic, inflammatory autoimmune disease targeting the synovium, the tissue that lines the joints. It is associated with increased risk of infection (pulmonary in particular), osteoporosis, and cardiovascular ..
  40. Pro-inflammatory role of megakaryocytes in arthritis
    Peter A Nigrovic; Fiscal Year: 2013 applicant): Pro-inflammatory role of megakaryocytes in arthritis Project Summary In inflammatory arthritis, the joints become the focus of intense immunological attack, frequently leading to irreversible injury and long-term ..
  41. Evaluation of an MRI Biomarker for Meniscal Repair
    Hollis G Potter; Fiscal Year: 2010
    ..After imaging, the knee joints will be disarticulated and tissue samples for biomechanical testing and histological examination of the repair ..
  42. Mapping Expression Quantitative Trait Loci with Next Generation Sequencing in SLE
    Min Chen; Fiscal Year: 2013 autoimmune disease that leads to chronic inflammation and may affect any part of the body, especially the skin, joints, kidneys, brain, and blood. It is estimated that over 1...
  43. Genome-wide SNP association in psoriasis
    ANNE MARY BOWCOCK; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Psoriasis and psoriatic arthritis are chronic inflammatory diseases of the skin and joints for which there are no cures. Total direct and indirect health care costs are ~ $11...
  44. RANKL and Inflammation-associated Bone Loss
    CHARLES A O'BRIEN; Fiscal Year: 2012
    Project Summary/Abstract Loss of bone mass throughout the body, and especially adjacent to inflamed joints, is a major cause of morbidity and fracture in veterans with rheumatic diseases...
  45. Effect of Articular Neurotoxin on Joint Pain and Neurochemical Signature
    Maren Lawson Mahowald; Fiscal Year: 2012
    ..These models will be produced by injecting mouse knee joints with carrageenan, and Complete Freund's Adjuvant and by destabilizing the medial meniscus of the knee ..
  46. Hematopoietic gene therapy for hemophilia A
    H Trent Spencer; Fiscal Year: 2013
    ..that block treatment efficacy, 3) morbidity due to joint disease resulting from repeated bleeding into individual joints and 4) the limitation of treatment to 30% of the world population...
  47. Regeneration of the Developing Chick Elbow Joint
    Rosalie Anderson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Regeneration of the Developing Chick Elbow Joint Project Summary Synovial joints such as those that comprise the elbow, knee, and hip are extremely important for functioning in everyday life...
  48. The Johnston County OA Project: Arthritis and Disability
    Joanne M Jordan; Fiscal Year: 2013
    ..All individuals will complete radiographic examinations of the knees, hips, patellofemoral joints, hands, and lumbar spine, physical and functional examination, extensive interviews, and DEXA, and contribute ..
  49. Neuropeptides and Regulatory T cells
    Doina Ganea; Fiscal Year: 2013
    ..We will assess LentiVIP-DC migration to spleen, CNS, and affected joints, and investigate the effects on clinical disease, on splenic and local cytokine/chemokine expression and on T cell ..
  50. Phase-contrast enhanced X-ray imaging system for small joints of hand
    Thomas J Beck; Fiscal Year: 2010
    ..It initially attacks the small joints of the hand and foot...
  51. Phase-contrast X-ray imaging system for large joints
    Dan Stutman; Fiscal Year: 2012
    ..These diseases affect a significant fraction of the world population and attack most of the joints in the body, including large joints such as the knee, hip, or shoulder...
  52. Gene enhanced cartilage repair in a cytokine permissive environment
    Alan J Nixon; Fiscal Year: 2012
    ..5) Assess enhanced cartilage repair from transplantation of IGF-I gene transduced chondrocytes to joints where catabolic activity is reduced by locally expressing IL-1b knockdown elements...
  53. Multiplex ALEX-based Test for Protease Activity Profiling in Arthritic Joints
    ARMIN H REITMAIR; Fiscal Year: 2013
    ..a next-generation multiplex test for protease activity profiling in minute synovial fluid samples from arthritic joints, using alternating laser excitation (ALEX) single molecule fluorescence spectroscopy...
  54. Role of BH3-domain proteins in the effector phase of RA
    HARRIS R PERLMAN; Fiscal Year: 2012
    ..During RA, the synovial lining invades and destroys the adjacent cartilage and bone. Analysis of tissue from joints of patients with RA revealed that the number of macrophages, correlated with a worse prognosis...
  55. Myeloid-derived Suppressor Cells in Autoimmune Arthritis
    Katalin Mikecz; Fiscal Year: 2012 the clinical management of rheumatoid arthritis (RA), a debilitating autoimmune disease affecting the synovial joints. However, a significant proportion of patients with RA do not respond adequately to biologic agents, and for those,..
  56. Comparative Effectiveness of Customary Fit and Strong! vs. Fit and Strong! Plus
    Susan L Hughes; Fiscal Year: 2013
    ..Reduced pain and stiffness in weight bearing joints may help reduce demand for total joint replacement surgery in this population.
  57. Lubricin Function in Articulating Joints
    Matthew L Warman; Fiscal Year: 2012
    ..investigators have shown that lubricin is critically important in the protection and maintenance of articulating joints. We have demonstrated that lubricin prevents mechanical wear of articular cartilage...
  58. Monitoring of Stem Cell Engraftment in Arthritic Joints with MR Imaging
    ..Cartilage defects are the major source of pain in the affected joints. Current treatments, whilst alleviating some of the clinical symptoms, prove insufficient to cure the underlying ..
  59. Role of Transcription Factor ERG in Skeletogenesis
    Maurizio Pacifici; Fiscal Year: 2013
    ..To test function, we created floxed Erg mice and conditionally ablated Erg in developing joints by mating with Gdf5-Cre mice...
  60. Humoral responses to Lyme Borreliosis: A mouse model
    Nicole Baumgarth; Fiscal Year: 2012
    ..transfers a bacterium, Borrelia burgdorferi, to the patient, which can persist in various organs, including the joints and heart, where it can cause disabling disease such as chronic arthritis and heart muscle disease...
  61. Regulatory Mechanisms of Implant-Induced Osteolysis
    Yousef Abu-Amer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Degenerative conditions of large weight bearing joints resulting from aging and/or pathologic conditions such as arthritis and osteoporosis lead to surgical intervention approaches chiefly total joint ..
    Ann Marshak Rothstein; Fiscal Year: 2010
    ..antibodies and/or immune complexes containing these antibodies can deposit in blood vessel walls, glomeruli, and joints and contribute to complications ranging from glomerulonephritis to coagulation disorders...
    STEVEN KINCAID; Fiscal Year: 1991
    ..Treatment of osteoarthritic joints with injections of hyaluronic acid has proven to provide short term improvement of clinical signs possibly because ..
  64. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    ..damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, muscles and joints. Scleroderma typically strikes between ages 25 and 55, and women are four times more likely than men to be ..
    Michael Nevitt; Fiscal Year: 1992
    ..The best study would measure bone mass near joints that are affected by OA...
  66. EMG Biofeedback with AMES
    Paul Cordo; Fiscal Year: 2007
    ..our success at treating profoundly disabled stroke victims, AMES treatment did not restore functional movement at joints (e.g., fingers, wrist, and ankle) rendered completely plegic by the stroke...
    CLAIRE FARLEY; Fiscal Year: 2000
    ..Because these musculoskeletal elements change length when joints flex or extend, it is not surprising that joints exhibit spring-like characteristics...
  68. Neuromuscular and positional changes after ankle joint mobilizations
    Jay N Hertel; Fiscal Year: 2010
    ..a single bout of Maitland grade 3 anteroposterior (AP) mobilizations of the distal tibiofibular and talocrural joints in subjects with chronic lateral ankle instability (CLAI)...
  69. Restitution of Lubrication in ACL Deficient Joints Preventing Wear
    Gregory Jay; Fiscal Year: 2009
    ..TNF-a through the administration of a TNF-a inhibitor partially restores the lubricating ability of diarthrodial joints following ACL injury...
    GAIL HABICHT; Fiscal Year: 1993
    ..known as erythema chronicum migrans (ECM) and, in decreasing order of frequency, by arthritis usually of the large joints, neurological and cardiac complications...
  71. Micellar VIP Nanoparticles for Rheumatoid Arthritis
    Israel Rubinstein; Fiscal Year: 2007
    ..and safety of an innovative strategy developed in our laboratory consisting of homing low dose VIP to injured joints in rheumatoid arthritis...
    KAMAL MOUDGIL; Fiscal Year: 2005
    ..It is believed that in AA, the T cells primed by Bhsp65 (within Mtb) migrate into the synovium of joints and cause tissue damage presumably by recognizing a crossreactive self antigen (that has not yet been fully ..
  73. Robotic Prosthesis for Biomimetic Locomotion in Transfemoral Amputees
    Michael Goldfarb; Fiscal Year: 2010
    The overarching hypothesis of this proposal that a prosthesis with actively powered knee and ankle joints will significantly enhance the mobility of many transfemoral amputees, and therefore significantly enhance their quality of life...
    Virginia Kraus; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Applicant's Abstract): Osteoarthritis (OA) is a degenerative process in joints characterized by functional deterioration, abrasion of articular cartilage and formation of new bone at and around joint surfaces...
  75. Nanostructured Zirconia Ceramics for Joint Prosthetics
    ANTHONY SUTORIK; Fiscal Year: 2004
    ..sufficient failures of European manufactured hip components that the FDA forced a recall of all zirconia-based joints with no replacements forthcoming. Biopro, a Port Huron, MI company co-founded by Dr...
    Raphael Hirsch; Fiscal Year: 2010
    ..digitizer cameras and thermal infrared cameras-to rapidly quantify surface swelling and heat in arthritic joints. This Arthritis Surface Imager produces results within minutes...
  77. Flavocoxid: A Medical Food Therapy for Osteoarthritis
    Sarah Morgan; Fiscal Year: 2004 a leading chronic disease in older adults characterized by degeneration of articular cartilage of the joints in hands, spine, knees and hips...