lumbar vertebrae

Summary

Top Publications

  1. ncbi Magnetic resonance classification of lumbar intervertebral disc degeneration
    C W Pfirrmann
    Division of Musculoskeletal Radiology, Orthopedic University Hospital, Balgrist Zurich, Switzerland
    Spine (Phila Pa 1976) 26:1873-8. 2001
  2. ncbi Intraoperative and early postoperative complications in extreme lateral interbody fusion: an analysis of 600 cases
    W Blake Rodgers
    Spine Midwest, Inc, Jefferson City, Missouri, USA
    Spine (Phila Pa 1976) 36:26-32. 2011
  3. ncbi Minimally invasive surgery: lateral approach interbody fusion: results and review
    Jim A Youssef
    Durango Orthopedic Associates, Spine Colorado, Durango, CO, USA
    Spine (Phila Pa 1976) 35:S302-11. 2010
  4. ncbi A radiographic assessment of the ability of the extreme lateral interbody fusion procedure to indirectly decompress the neural elements
    Leonardo Oliveira
    Instituto de Patologia de Coluna, Sao Paulo, Brazil
    Spine (Phila Pa 1976) 35:S331-7. 2010
  5. ncbi The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    Pierre J Meunier
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
    N Engl J Med 350:459-68. 2004
  6. ncbi Defining the safe working zones using the minimally invasive lateral retroperitoneal transpsoas approach: an anatomical study
    Juan S Uribe
    Department of Neurological Surgery, University of South Florida, Tampa, Florida 33606, USA
    J Neurosurg Spine 13:260-6. 2010
  7. pmc Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults
    Richard A Deyo
    Department of Family Medicine, Mail Code FM, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    JAMA 303:1259-65. 2010
  8. ncbi Interaction between the porcine lumbar intervertebral disc, zygapophysial joints, and paraspinal muscles
    A Indahl
    Spine Clinic, Ostfold Central Hospital, Fredrikstad, Norway
    Spine (Phila Pa 1976) 22:2834-40. 1997
  9. ncbi Evaluation of the effectiveness of lumbar interlaminar epidural injections in managing chronic pain of lumbar disc herniation or radiculitis: a randomized, double-blind, controlled trial
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 13:343-55. 2010
  10. ncbi Surgery versus prolonged conservative treatment for sciatica
    Wilco C Peul
    Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
    N Engl J Med 356:2245-56. 2007

Detail Information

Publications375 found, 100 shown here

  1. ncbi Magnetic resonance classification of lumbar intervertebral disc degeneration
    C W Pfirrmann
    Division of Musculoskeletal Radiology, Orthopedic University Hospital, Balgrist Zurich, Switzerland
    Spine (Phila Pa 1976) 26:1873-8. 2001
    ..3% of all the cases. CONCLUSION: Disc degeneration can be graded reliably on routine T2-weighted magnetic resonance images using the grading system and algorithm presented in this investigation...
  2. ncbi Intraoperative and early postoperative complications in extreme lateral interbody fusion: an analysis of 600 cases
    W Blake Rodgers
    Spine Midwest, Inc, Jefferson City, Missouri, USA
    Spine (Phila Pa 1976) 36:26-32. 2011
    ..Prospective analysis of 600 extreme lateral interbody fusion (XLIF) approach procedures for intraoperative and perioperative complications...
  3. ncbi Minimally invasive surgery: lateral approach interbody fusion: results and review
    Jim A Youssef
    Durango Orthopedic Associates, Spine Colorado, Durango, CO, USA
    Spine (Phila Pa 1976) 35:S302-11. 2010
    ..A retrospective review of patients treated at 2 institutions with anterior lumbar interbody fusion using a minimally invasive lateral retroperitoneal approach, and review of literature...
  4. ncbi A radiographic assessment of the ability of the extreme lateral interbody fusion procedure to indirectly decompress the neural elements
    Leonardo Oliveira
    Instituto de Patologia de Coluna, Sao Paulo, Brazil
    Spine (Phila Pa 1976) 35:S331-7. 2010
    ..Prospective nonrandomized clinical study on the decompressive effect of the extreme lateral interbody fusion (XLIF) procedure...
  5. ncbi The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    Pierre J Meunier
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
    N Engl J Med 350:459-68. 2004
    ....
  6. ncbi Defining the safe working zones using the minimally invasive lateral retroperitoneal transpsoas approach: an anatomical study
    Juan S Uribe
    Department of Neurological Surgery, University of South Florida, Tampa, Florida 33606, USA
    J Neurosurg Spine 13:260-6. 2010
    ..The authors undertook this anatomical cadaveric dissection study to define the anatomical safe zones relative to the disc spaces for prevention of nerve injuries during the lateral retroperitoneal transpsoas approach...
  7. pmc Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults
    Richard A Deyo
    Department of Family Medicine, Mail Code FM, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    JAMA 303:1259-65. 2010
    ..Comorbidity is common in older patients, so benefits and risks must be carefully weighed in the choice of surgical procedure...
  8. ncbi Interaction between the porcine lumbar intervertebral disc, zygapophysial joints, and paraspinal muscles
    A Indahl
    Spine Clinic, Ostfold Central Hospital, Fredrikstad, Norway
    Spine (Phila Pa 1976) 22:2834-40. 1997
    ..The zygapophysial joints may therefore have a regulating function, controlling the intricate neuromuscular balance in the lumbar motion segment...
  9. ncbi Evaluation of the effectiveness of lumbar interlaminar epidural injections in managing chronic pain of lumbar disc herniation or radiculitis: a randomized, double-blind, controlled trial
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 13:343-55. 2010
    ..2% to 43%. Among the numerous non-surgical interventions available, epidural injections are the most commonly performed interventions in the United States in managing chronic low back and lower extremity pain...
  10. ncbi Surgery versus prolonged conservative treatment for sciatica
    Wilco C Peul
    Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
    N Engl J Med 356:2245-56. 2007
    ..Lumbar-disk surgery often is performed in patients who have sciatica that does not resolve within 6 weeks, but the optimal timing of surgery is not known...
  11. ncbi Surgery versus conservative treatment for symptomatic lumbar spinal stenosis: a systematic review of randomized controlled trials
    Francisco M Kovacs
    Departamento Cientifico, Fundacion Kovacs, Palma de Mallorca, Spain
    Spine (Phila Pa 1976) 36:E1335-51. 2011
    ..Systematic review...
  12. ncbi Dynamically evoked, discrete-threshold electromyography in the extreme lateral interbody fusion approach
    Antoine G Tohmeh
    Northwest Orthopaedic Specialists, Spokane, Washington
    J Neurosurg Spine 14:31-7. 2011
    ..This study was performed to assess the effectiveness of dynamically evoked electromyography (EMG) to detect and prevent neural injury during the XLIF approach...
  13. ncbi The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy
    N Hayashi
    Department of Orthopedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 23:877-85. 1998
    ..CONCLUSIONS: Epidural steroid injection has a significant effect on the thermal hyperalgesia produced in a model of radiculopathy, which may provide clinical support for advocates of epidural steroids...
  14. ncbi Lateral lumbar interbody fusion: clinical and radiographic outcomes at 1 year: a preliminary report
    Amit K Sharma
    Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN, USA
    J Spinal Disord Tech 24:242-50. 2011
    ..A retrospective review of patients' radiographs and charts...
  15. ncbi Biomechanical analysis and review of lateral lumbar fusion constructs
    Andrew Cappuccino
    Buffalo Spine Surgery, Lockport, NY, USA
    Spine (Phila Pa 1976) 35:S361-7. 2010
    ..Biomechanical study and the review of literature on lumbar interbody fusion constructs...
  16. ncbi 2001 Volvo Award Winner in Clinical Studies: Lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group
    P Fritzell
    Department of Orthopedic Surgery, Falun Hospital, 79182 Falun, Sweden
    Spine (Phila Pa 1976) 26:2521-32; discussion 2532-4. 2001
    ..A randomized controlled multicenter study with a 2-year follow-up by an independent observer...
  17. ncbi Results of the prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement versus circumferential fusion for the treatment of 1-level degenerative disc disease
    Jack Zigler
    Texas Back Institute Texas Health Research Institute, Plano, TX 75093, USA
    Spine (Phila Pa 1976) 32:1155-62; discussion 1163. 2007
    ..A prospective, randomized, multicenter, Food and Drug Administration-regulated Investigational Device Exemption clinical trial...
  18. ncbi Adjacent segment disease after lumbar or lumbosacral fusion: review of the literature
    Paul Park
    Department of Neurosurgery, University of Michigan Health System, Ann Arbor, MI 48109 0338, USA
    Spine (Phila Pa 1976) 29:1938-44. 2004
    ..Review of the literature...
  19. ncbi New in vivo measurements of pressures in the intervertebral disc in daily life
    H J Wilke
    Abteilung für kräftigungstherapie und Rehabilitation, Schmerzklinik Kirschgarten, Basel, Switzerland
    Spine (Phila Pa 1976) 24:755-62. 1999
    ..We conducted intradiscal pressure measurements with one volunteer performing various activities normally found in daily life, sports, and spinal therapy...
  20. ncbi Lumbar adjacent segment degeneration and disease after arthrodesis and total disc arthroplasty
    James S Harrop
    Department of Orthopaedics and Neurological Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    Spine (Phila Pa 1976) 33:1701-7. 2008
    ..Systematic review of published incidence of radiographic adjacent segment degeneration (ASDeg) and symptomatic adjacent segment disease (ASDis) after arthrodesis or total disc replacement...
  21. pmc Evaluation of lumbar facet joint nerve blocks in managing chronic low back pain: a randomized, double-blind, controlled trial with a 2-year follow-up
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Int J Med Sci 7:124-35. 2010
    ..A randomized, double-blind, controlled trial...
  22. ncbi Anterior lumbar interbody fusion in comparison with transforaminal lumbar interbody fusion: implications for the restoration of foraminal height, local disc angle, lumbar lordosis, and sagittal balance
    Patrick C Hsieh
    Department of Neurological Surgery, Feinberg School of Medicine, Northwestern Memorial Hospital, Northwestern University, Chicago, Illinois, USA
    J Neurosurg Spine 7:379-86. 2007
    ..The authors conducted a retrospective radiographic analysis directly comparing ALIF with TLIF in their capacity to alter foraminal height, local disc angle, and lumbar lordosis...
  23. ncbi Minimally invasive multilevel percutaneous correction and fusion for adult lumbar degenerative scoliosis: a technique and feasibility study
    Neel Anand
    Department of Surgery, Institute for Spinal Disorders, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Spinal Disord Tech 21:459-67. 2008
    ..Prospective evaluation of 12 patients undergoing surgery for lumbar degenerative scoliosis...
  24. ncbi Contribution of the anterior longitudinal ligament to ossification and growth of the vertebral body: an immunohistochemical study using the human fetal lumbar vertebrae
    Zhe Wu Jin
    Department of Surgery, Research Institute of Clinical Medicine, Chonbuk National University Hospital, 634 18 Keumam dong, Dukjin Gu, Jeonju, Jeonbuk 561 712, Korea
    Surg Radiol Anat 33:11-8. 2011
    ....
  25. ncbi Prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement compared with circumferential arthrodesis for the treatment of two-level lumbar degenerative disc disease: res
    Rick Delamarter
    The Spine Institute at Saint John s Health Center, 1301 20th Street, Suite 400, Santa Monica, CA 90404, USA
    J Bone Joint Surg Am 93:705-15. 2011
    ....
  26. ncbi Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
    R M Neer
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 344:1434-41. 2001
    ..The 40-microg dose increased bone mineral density more than the 20-microg dose but had similar effects on the risk of fracture and was more likely to have side effects...
  27. ncbi Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals
    Kenneth M C Cheung
    Department of Orthopaedics and Traumatology, University of Hong Kong, Hong Kong, China
    Spine (Phila Pa 1976) 34:934-40. 2009
    ..A cross-sectional population study of magnetic resonance imaging (MRI) changes. OBJECTIVE.: To examine the pattern and prevalence of lumbar spine MRI changes within a southern Chinese population and their relationship with back pain...
  28. ncbi Low back pain in relation to lumbar disc degeneration
    K Luoma
    Finnish Institute of Occupational Health, Helsinki, Finland
    Spine (Phila Pa 1976) 25:487-92. 2000
    ..Cross-sectional magnetic resonance imaging (MRI) study...
  29. ncbi Minimum clinically important difference in lumbar spine surgery patients: a choice of methods using the Oswestry Disability Index, Medical Outcomes Study questionnaire Short Form 36, and pain scales
    Anne G Copay
    The Spinal Research Foundation, 1831 Wiehle Avenue, Suite 200, Reston, VA 20190, USA
    Spine J 8:968-74. 2008
    ..Variable threshold values have been proposed as MCID for those instruments despite a lack of agreement on the optimal MCID calculation method...
  30. ncbi Prevalence of symptomatic lumbar spinal stenosis and its association with physical performance in a population-based cohort in Japan: the Wakayama Spine Study
    Y Ishimoto
    Wakayama Medical University, Wakayama City, Japan
    Osteoarthritis Cartilage 20:1103-8. 2012
    ....
  31. pmc Surgery versus conservative management of sciatica due to a lumbar herniated disc: a systematic review
    Wilco C H Jacobs
    Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Spine J 20:513-22. 2011
    ..Future studies should evaluate who benefits more from surgery and who from conservative care...
  32. ncbi Adult deformity correction through minimally invasive lateral approach techniques
    Gregory M Mundis
    San Diego Center for Spinal Disorder, La Jolla, CA, USA
    Spine (Phila Pa 1976) 35:S312-21. 2010
    ..Review of the available literature, authors' opinion...
  33. pmc Would loss to follow-up bias the outcome evaluation of patients operated for degenerative disorders of the lumbar spine?
    Tore K Solberg
    Department of Neurosurgery, University Hospital of Northern Norway, Tromsø, Norway
    Acta Orthop 82:56-63. 2011
    ..In addition, we wanted to identify risk factors for failure to respond...
  34. ncbi Changes in coronal and sagittal plane alignment following minimally invasive direct lateral interbody fusion for the treatment of degenerative lumbar disease in adults: a radiographic study
    Frank L Acosta
    Department of Neurological Surgery, Cedars Sinai Medical Center, Los Angeles 90048, USA
    J Neurosurg Spine 15:92-6. 2011
    ..The object of this study was to determine changes in sagittal and coronal plane alignment occurring after direct lateral interbody fusion (DLIF)...
  35. ncbi A prospective, randomized, multicenter Food and Drug Administration investigational device exemptions study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: part I: evaluation of clinical outcomes
    Scott Blumenthal
    Texas Back Institute, Plano, Texas 75093, USA
    Spine (Phila Pa 1976) 30:1565-75; discussion E387-91. 2005
    ..A prospective, randomized, multicenter, Food and Drug Administration-regulated Investigational Device Exemption clinical trial...
  36. ncbi Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study
    Nunziata Morabito
    Department of Internal Medicine, University of Messina, Italy
    J Bone Miner Res 17:1904-12. 2002
    ....
  37. pmc Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
    J B Richards
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Lancet 371:1505-12. 2008
    ..Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density...
  38. ncbi BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    J Bone Miner Res 21:1550-6. 2006
    ..The relationship between hip BMD and hip fracture risk seemed to be stronger than observed in a large prospective study of women. Hip BMD is an excellent test for predicting fracture risk in men...
  39. pmc Surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesis
    James N Weinstein
    Department of Orthopaedics, Dartmouth Medical School, Lebanon, NH, USA
    N Engl J Med 356:2257-70. 2007
    ..Management of degenerative spondylolisthesis with spinal stenosis is controversial. Surgery is widely used, but its effectiveness in comparison with that of nonsurgical treatment has not been demonstrated in controlled trials...
  40. pmc The relationship between facet joint osteoarthritis and disc degeneration of the lumbar spine: an MRI study
    A Fujiwara
    Department of Orthopaedic Surgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Eur Spine J 8:396-401. 1999
    ....
  41. ncbi United States trends in lumbar fusion surgery for degenerative conditions
    Richard A Deyo
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Spine (Phila Pa 1976) 30:1441-5; discussion 1446-7. 2005
    ..Retrospective cohort study using national sample administrative data...
  42. ncbi Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy
    T P Van Staa
    University of Southampton, Southampton, UK
    Arthritis Rheum 48:3224-9. 2003
    ..To evaluate predictors of vertebral fractures, including a threshold for bone mineral density (BMD), in patients receiving oral glucocorticoids (GCs)...
  43. ncbi Surgical complications of posterior lumbar interbody fusion with total facetectomy in 251 patients
    Shinya Okuda
    Department of Orthopaedic Surgery, Osaka Rosai Hospital, Osaka, Japan
    J Neurosurg Spine 4:304-9. 2006
    ..The purpose of the present study was to examine rates of intraoperative and postoperative complications of PLIF using a large number of cases with uniform instrumentation and a uniform fusion technique...
  44. ncbi Microdecompression for lumbar spinal canal stenosis
    B K Weiner
    Department of Orthopaedic Surgery, Summa Health Systems, Akron, Ohio, USA
    Spine (Phila Pa 1976) 24:2268-72. 1999
    ..Functional outcome scores doubled, and 87% of patients reported high satisfaction rates. CONCLUSIONS: Lumbar microdecompression is a minimally invasive technique that appears to provide excellent functional outcomes...
  45. ncbi Adult spinal deformity surgery: complications and outcomes in patients over age 60
    Michael D Daubs
    Washington University School of Medicine and Department of Orthopedics, St Louis, MO 63110, USA
    Spine (Phila Pa 1976) 32:2238-44. 2007
    ..A retrospective analysis, including prospectively collected patient outcomes data...
  46. ncbi Biomechanical evaluation of lumbar spinal stability after graded facetectomies
    K Abumi
    Department of Orthopaedic Surgery, Hokkaido University, School of Medicine, Sapporo, Japan
    Spine (Phila Pa 1976) 15:1142-7. 1990
    ..This study suggested that medial facetectomy does not affect lumbar spinal stability, and conversely, total facetectomy, even created unilaterally, makes the lumbar spine unstable...
  47. ncbi Early complications of extreme lateral interbody fusion in the obese
    William B Rodgers
    Spine Midwest, Inc, Mary s Medical Plaza Ste, Jefferson City, MO 65101, USA
    J Spinal Disord Tech 23:393-7. 2010
    ..A retrospective review of prospective data of all patients undergoing extreme lateral interbody fusion (XLIF) for degenerative disease of the lumbar and thoracic spine...
  48. pmc Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
    Fernando Rivadeneira
    Department of Internal Medicine, Rotterdam, The Netherlands
    Nat Genet 41:1199-206. 2009
    ..The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD...
  49. ncbi Magnetic resonance imaging and low back pain in adults: a diagnostic imaging study of 40-year-old men and women
    Per Kjaer
    The Back Research Center, Backcenter Funen, Ringe, Denmark
    Spine (Phila Pa 1976) 30:1173-80. 2005
    ..Cross-sectional cohort study of a general population...
  50. pmc Total disc replacement surgery for symptomatic degenerative lumbar disc disease: a systematic review of the literature
    Karin D van den Eerenbeemt
    Department of Orthopaedics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur Spine J 19:1262-80. 2010
    ..High quality randomized controlled trials with relevant control group and long-term follow-up is needed to evaluate the effectiveness and safety of TDR...
  51. ncbi Randomized clinical trial of lumbar instrumented fusion and cognitive intervention and exercises in patients with chronic low back pain and disc degeneration
    Jens Ivar Brox
    Department of Orthopedic Surgery, National Hospital, Oslo, Norway
    Spine (Phila Pa 1976) 28:1913-21. 2003
    ..Single blind randomized study...
  52. ncbi An epidemiologic study of MRI and low back pain in 13-year-old children
    Per Kjaer
    The Back Research Center, Backcenter Funen and University of Southern Denmark, Lindevej, Denmark
    Spine (Phila Pa 1976) 30:798-806. 2005
    ..Cross-sectional cohort study of a general population...
  53. ncbi Recombinant human parathyroid hormone (1-34) [teriparatide] improves both cortical and cancellous bone structure
    Yebin Jiang
    Osteoporosis and Arthritis Research Group, Department of Radiology, University of California, San Francisco, California 94143 0628, USA
    J Bone Miner Res 18:1932-41. 2003
    ....
  54. ncbi Prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: five-year follow-up
    Richard D Guyer
    Texas Back Institute, 6020 West Parker Road, Suite 200, Plano, TX 75093, USA
    Spine J 9:374-86. 2009
    ..No long-term, randomized, prospective study on the CHARITE disc or any other artificial disc has been published to date...
  55. ncbi Relationship between pulmonary emphysema and osteoporosis assessed by CT in patients with COPD
    Tadashi Ohara
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Chest 134:1244-9. 2008
    ..Our second aim was to investigate the relationships among CT scan measurements, anthropometric parameters, and pulmonary function...
  56. ncbi Bone mass and bone size in pre- or early pubertal 10-year-old black and white South African children and their parents
    L Vidulich
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Calcif Tissue Int 88:281-93. 2011
    ..Heritability was comparable between environmentally disadvantaged black and advantaged white South African children and similar to that reported for Caucasians in other parts of the world...
  57. ncbi X-stop versus decompressive surgery for lumbar neurogenic intermittent claudication: randomized controlled trial with 2-year follow-up
    Björn H Strömqvist
    Department of Orthopedics, Clinical Sciences Lund, Lund University, Skane University Hospital, Malmo, Sweden
    Spine (Phila Pa 1976) 38:1436-42. 2013
    ..Prospective randomized controlled study...
  58. ncbi 1997 Volvo Award winner in clinical studies. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation
    J S Fischgrund
    William Beaumont Hospital, Department of Orthopaedic Surgery, Royal Oak, Michigan, USA
    Spine (Phila Pa 1976) 22:2807-12. 1997
    ....
  59. ncbi Magnetic resonance imaging in follow-up assessment of sciatica
    Abdelilah El Barzouhi
    Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
    N Engl J Med 368:999-1007. 2013
    ..Magnetic resonance imaging (MRI) is frequently performed during follow-up in patients with known lumbar-disk herniation and persistent symptoms of sciatica. The association between findings on MRI and clinical outcome is controversial...
  60. ncbi Prevalence of degenerative imaging findings in lumbar magnetic resonance imaging among young adults
    Jani Takatalo
    Department of Physical and Rehabilitation Medicine, Institute of Clinical Sciences, University of Oulu, Oulu, Finland
    Spine (Phila Pa 1976) 34:1716-21. 2009
    ..A cross-sectional imaging study of young adults...
  61. pmc Prognostic factors in lumbar spinal stenosis surgery
    Freyr G Sigmundsson
    Department of Orthopedics, Clinical Sciences, Lund University, Skane University Hospital, Lund, Sweden
    Acta Orthop 83:536-42. 2012
    ..There have been few studies on factors that may predict outcome. We tried to find predictors of outcome in surgery for spinal stenosis using patient- and imaging-related factors...
  62. ncbi The association between lumbar disc degeneration and low back pain: the influence of age, gender, and individual radiographic features
    Evelien I T de Schepper
    Departments of General Practice, Erasmus MC, Rotterdam, The Netherlands
    Spine (Phila Pa 1976) 35:531-6. 2010
    ..Cross-sectional open population based study (nested in a prospective cohort study)...
  63. ncbi Axial T2 mapping in intervertebral discs: a new technique for assessment of intervertebral disc degeneration
    Sven Hoppe
    Department of Orthopaedic Surgery, Inselspital, Berne University Hospital, 3010 Berne, Switzerland
    Eur Radiol 22:2013-9. 2012
    ..5-Tesla magnetic resonance imaging (MRI) in a clinical setting...
  64. ncbi Dynamic change of dural sac cross-sectional area in axial loaded magnetic resonance imaging correlates with the severity of clinical symptoms in patients with lumbar spinal canal stenosis
    Haruo Kanno
    Department of Orthopedic Surgery, Tohoku University School of Medicine, Sendai, Japan
    Spine (Phila Pa 1976) 37:207-13. 2012
    ..OBJECTIVE.: To examine whether the dural sac cross-sectional area (DCSA) in axial loaded magnetic resonance imaging (MRI) correlates with the severity of clinical symptoms in patients with lumbar spinal canal stenosis (LSCS)...
  65. pmc Stand-alone cage for posterior lumbar interbody fusion in the treatment of high-degree degenerative disc disease: design of a new device for an "old" technique. A prospective study on a series of 116 patients
    Francesco Costa
    Neurosurgery Department, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
    Eur Spine J 20:S46-56. 2011
    ..This technique is not demanding and can be considered safe and effective, as shown by the excellent clinical and radiological success rates...
  66. pmc Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain
    Tue Secher Jensen
    The Back Research Center, Lindevej 5, Ringe, Denmark
    Eur Spine J 17:1407-22. 2008
    ..0 to 19.9. This systematic review shows that VESC is a common MRI-finding in patients with non-specific LBP and is associated with pain. However, it should be noted that VESC may be present in individuals without LBP...
  67. pmc Correlation between disability and MRI findings in lumbar spinal stenosis: a prospective study of 109 patients operated on by decompression
    Freyr G Sigmundsson
    Department of Orthopedics, Clincal Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden
    Acta Orthop 82:204-10. 2011
    ..We assessed this relationship in a prospective study...
  68. ncbi Biomechanical comparison of different techniques in primary spinal surgery in osteoporotic cadaveric lumbar vertebrae: expansive pedicle screw versus polymethylmethacrylate-augmented pedicle screw
    Da Liu
    Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, People s Republic of China
    Arch Orthop Trauma Surg 131:1227-32. 2011
    ..The purpose of this study was to compare the stability of EPS and PMMA-PS in primary spinal surgery...
  69. ncbi MR imaging assessment of lumbar intervertebral disk degeneration and age-related changes: apparent diffusion coefficient versus T2 quantitation
    G Niu
    Department of Diagnostic Radiology, First Hospital of Medical School, Xi an Jiaotong University, Xi an, China
    AJNR Am J Neuroradiol 32:1617-23. 2011
    ..T2 and ADC mappings are 2 quantitative MR imaging tools for assessing IVDD. This study aimed to compare these 2 measures in detecting IVDD and its age-related changes...
  70. ncbi Safe working zones using the minimally invasive lateral retroperitoneal transpsoas approach: a morphometric study
    Patrick Guerin
    Laboratoire d Anatomie Médico Chirurgicale Appliquée, Universite Victor Segalen, Bordeaux 2, 146 rue Leo Saignat, 33000, Bordeaux, France
    Surg Radiol Anat 33:665-71. 2011
    ....
  71. ncbi Does lumbar disc degeneration on magnetic resonance imaging associate with low back symptom severity in young Finnish adults?
    Jani Takatalo
    Institute of Clinical Sciences, University of Oulu, Oulu, Finland
    Spine (Phila Pa 1976) 36:2180-9. 2011
    ..A cross-sectional magnetic resonance imaging study with questionnaires on low back pain (LBP) and functional limitations...
  72. ncbi Neurological manifestations, imaging characteristics, and surgical outcome of intraspinal osteochondroma
    Iraj Lotfinia
    Department of Neurosurgery, Shohada Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
    J Neurosurg Spine 12:474-89. 2010
    ..Concurrent spinal cord compression is a very rare entity. The purpose of this study was to evaluate the authors' 10-year experience with the imaging characteristics and surgical outcome in patients with symptomatic spinal OC...
  73. ncbi No difference in long-term trunk muscle strength, cross-sectional area, and density in patients with chronic low back pain 7 to 11 years after lumbar fusion versus cognitive intervention and exercises
    Anne Froholdt
    Division of Orthopedic Surgery, Department of Orthopedics, Oslo University Hospital, Rikshospitalet, PB 4950 Nydalen, 0424 Oslo, Norway
    Spine J 11:718-25. 2011
    ..Reduced muscle strength and density observed at 1 year after lumbar fusion may deteriorate more in the long term...
  74. ncbi Disc degeneration of the lumbar spine in relation to overweight
    M Liuke
    Department of Epidemiology and Biostatistics, Finnish Institute of Occupational Health, Topeliuksenkatu 41a A, Helsinki, Finland
    Int J Obes (Lond) 29:903-8. 2005
    ..To study the association between overweight and lumbar disc degeneration...
  75. ncbi A prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: part II: evaluation of radiographic outcomes and correlation
    Paul C McAfee
    Spine and Scoliosis Center, St Joseph s Hospital, Baltimore, Maryland, USA
    Spine (Phila Pa 1976) 30:1576-83; discussion E388-90. 2005
    ..A prospective, randomized, multicenter, Food and Drug Administration-regulated, investigational device exemption clinical trial...
  76. ncbi Lumbar instrumented fusion compared with cognitive intervention and exercises in patients with chronic back pain after previous surgery for disc herniation: a prospective randomized controlled study
    Jens Ivar Brox
    Department of Orthopedics and Physiotherapy, Rikshospitalet University Hospital and Medical Faculty University in Oslo, Norway
    Pain 122:145-55. 2006
    ..For patients with chronic low back pain after previous surgery for disc herniation, lumbar fusion failed to show any benefit over cognitive intervention and exercises...
  77. pmc Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
    Gregory Livshits
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Ann Rheum Dis 70:1740-5. 2011
    ..The authors examined the contribution of genetic factors, lumbar disc degeneration (LDD) and other risk factors in a female sample of the general population...
  78. ncbi Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration
    James Melrose
    Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, The Royal North Shore Hospital of Sydney, St Leonards, New South Wales, Australia
    Spine (Phila Pa 1976) 37:18-25. 2012
    ....
  79. ncbi Intra- and interobserver reproducibility of vertebral endplate signal (modic) changes in the lumbar spine: the Nordic Modic Consensus Group classification
    T S Jensen
    Back Research Center, Clinical Locomotion Science, University of Southern Denmark, Lindevej 5, DK 5750 Ringe, Denmark
    Acta Radiol 48:748-54. 2007
    ..However, in relation to future research, there is need for a reliable and detailed magnetic resonance imaging (MRI) protocol to be used in the evaluation of vertebral endplate signal changes...
  80. ncbi Local axon collaterals of lamina I projection neurons in the spinal cord of young rats
    Peter Szucs
    Instituto de Biologia Molecular e Celular IBMC, Universidade do Porto, Porto, Portugal
    J Comp Neurol 518:2645-65. 2010
    ..Our results suggest that lamina I ALT projection neurons can additionally function as local-circuit and propriospinal neurons participating in intra- and intersegmental spinal cord processing...
  81. ncbi The Twin Spine Study: contributions to a changing view of disc degeneration
    Michele C Battie
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada
    Spine J 9:47-59. 2009
    ..The Twin Spine Study, a research program on the etiology and pathogenesis of disc degeneration, has contributed to a substantial revision of this view of determinants of lumbar disc degeneration...
  82. pmc Two-year results of interspinous spacer (X-Stop) implantation in 175 patients with neurologic intermittent claudication due to lumbar spinal stenosis
    Johannes Kuchta
    Department of Neurosurgery, MediaParc Clinic, Cologne, Germany
    Eur Spine J 18:823-9. 2009
    ..Functional (upright-) MRI examinations were able to demonstrate the positional-dependent stenosis. If available, fMRI represents the most helpful radiologic examination in assessing the outcome of interspinous spacer implantation...
  83. pmc Interspinous implants (X Stop, Wallis, Diam) for the treatment of LSS: is there a correlation between radiological parameters and clinical outcome?
    Rolf Sobottke
    Department of Orthopaedic and Trauma Surgery, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
    Eur Spine J 18:1494-503. 2009
    ..The interspinous implant offers significant, longlasting symptom control, even if initially significant radiological changes seem to revert toward the initial values ("loss of correction")...
  84. ncbi Dynamic interspinous process stabilization: review of complications associated with the X-Stop device
    Christian Bowers
    Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
    Neurosurg Focus 28:E8. 2010
    ..In this paper, the authors reviewed the complications and failure/reoperation rates in a small series of patients and compared their results with other reported complication and failure/reoperation rates...
  85. ncbi Measurement properties of a self-administered outcome measure in lumbar spinal stenosis
    G Stucki
    Department of Rheumatology and Physical Medicine, University Hospital, Zurich, Switzerland
    Spine (Phila Pa 1976) 21:796-803. 1996
    ..This short self-administered spinal stenosis measure is reproducible, internally consistent, valid, and highly responsive. It can be used to complement generic instruments in outcome assessment of patients with lumbar spinal stenosis...
  86. ncbi Aperius PercLID stand alone interspinous system for the treatment of degenerative lumbar stenosis: experience on 152 cases
    Piervittorio Nardi
    Neurosurgical Unit, Policlinico Casilino, Rome, Italy
    J Spinal Disord Tech 23:203-7. 2010
    ..This study is a retrospective clinical investigation of a new interspinous device implanted via a totally percutaneous technique involving 152 consecutive patients...
  87. pmc Role of trabecular microarchitecture and its heterogeneity parameters in the mechanical behavior of ex vivo human L3 vertebrae
    Julien Wegrzyn
    INSERM Research Unit 831, Universite de Lyon, Lyon, France
    J Bone Miner Res 25:2324-31. 2010
    ..the contributions of trabecular microarchitecture and its heterogeneity to the mechanical behavior of human lumbar vertebrae. Twenty-one human L(3) vertebrae were analyzed for BMD by dual-energy X-ray absorptiometry (DXA) and ..
  88. ncbi Twelve-months follow-up in forty-nine patients with acute/semiacute osteoporotic vertebral fractures treated conservatively or with percutaneous vertebroplasty: a clinical randomized study
    Rikke Rousing
    Spine Section, Department of Orthopaedics, University Hospital of Odense, Odense, Denmark
    Spine (Phila Pa 1976) 35:478-82. 2010
    ..Clinical randomized study...
  89. ncbi Increase in vertebral body size in postmenopausal women with osteoporosis
    K Briot
    Paris Descartes University, Rheumatology Department, Cochin Hospital, Paris, France
    Bone 47:229-34. 2010
    ..01). These prospective results demonstrate that vertebral body dimensions increase over 3 years in women with postmenopausal osteoporosis...
  90. pmc Lumbar spinal stenosis
    Stephane Genevay
    Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland
    Best Pract Res Clin Rheumatol 24:253-65. 2010
    ..Recommendations favour a shared decision-making approach due to important trade-offs between alternative therapies and differences among patients in their preferences and values...
  91. ncbi Biomechanical study of pedicle screw fixation in severely osteoporotic bone
    Stephen D Cook
    Tulane University Health Sciences Center, Department of Orthopaedic Surgery, 1430 Tulane Avenue, SL 32, New Orleans, LA 70112, USA
    Spine J 4:402-8. 2004
    ..An expandable pedicle screw design has been shown to significantly improve fixation compared to a conventional screw in poor quality bone...
  92. ncbi Lumbar disc degeneration: epidemiology and genetic influences
    Michele C Battie
    Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada
    Spine (Phila Pa 1976) 29:2679-90. 2004
    ..A literature review...
  93. ncbi Inflammatory cytokines in the herniated disc of the lumbar spine
    H Takahashi
    First Department of Orthopaedic Surgery, Tokyo, Japan
    Spine (Phila Pa 1976) 21:218-24. 1996
    ..Further studies are required to elucidate the role of inflammatory cytokines in causing sciatic pain...
  94. ncbi Factors associated with lumbar intervertebral disc degeneration in the elderly
    Mika Hangai
    Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Ten nodai, Tsukuba, Ibaraki, 305 8575, Japan
    Spine J 8:732-40. 2008
    ....
  95. pmc Sagittal spinopelvic balance in normal children and adolescents
    Jean Marc Mac-Thiong
    Division of Orthopaedics, Hopital Sainte Justine, Montreal, QC, Canada
    Eur Spine J 16:227-34. 2007
    ..Results from this study could be used as an aid for the planning of surgery in pediatric patients with spinal deformity in order to restore a relatively normal sagittal spinopelvic balance...
  96. ncbi Primary pedicle screw augmentation in osteoporotic lumbar vertebrae: biomechanical analysis of pedicle fixation strength
    Daniel J Burval
    Cleveland Clinic Foundation, Cleveland Clinic Spine Institute, Cleveland, OH 44195, USA
    Spine (Phila Pa 1976) 32:1077-83. 2007
    ..Pedicle screw pullout testing in osteoporotic and control human cadaveric vertebrae, comparing augmented and control vertebrae...
  97. ncbi Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation-related scar tissue
    Koichi Sairyo
    Spine Research Center, Department of Bioengineering and Orthopedics, University of Toledo, Toledo, OH 43606, USA
    Spine (Phila Pa 1976) 32:E340-7. 2007
    ..A histologic, biologic, and immunohistochemical assessment using human samples of the lumbar ligamentum flavum...
  98. ncbi A follower load increases the load-carrying capacity of the lumbar spine in compression
    A G Patwardhan
    Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, Illinois
    Spine (Phila Pa 1976) 24:1003-9. 1999
    ..An experimental approach was used to test human cadaveric spine specimens...
  99. ncbi The value of T2 relaxation times to characterize lumbar intervertebral disks: preliminary results
    J Perry
    Department of Radiology, University of Wisconsin, Hospitals and Clinics, Madison, Wisconsin 53792 3252, USA
    AJNR Am J Neuroradiol 27:337-42. 2006
    ..The purpose of this pilot study was to investigate the use of T2 measurements as a continuous measure of intervertebral disk degeneration...
  100. ncbi Transfer of loads between lumbar tissues during the flexion-relaxation phenomenon
    S M McGill
    Department of Kinesiology, Faculty of Applied Health Sciences, University of Waterloo, Ontario, Canada
    Spine (Phila Pa 1976) 19:2190-6. 1994
    ..Loading of the interspinous and supraspinous ligaments, in particular, was high relative to their failure tolerance...
  101. ncbi Atherosclerosis and disc degeneration/low-back pain--a systematic review
    L I Kauppila
    Terveystalo Healthcare, Helsinki, Finland
    Eur J Vasc Endovasc Surg 37:661-70. 2009
    ..The diminished blood flow could result in various back problems. The aim of this systematic literature review was to assess associations between atherosclerosis and disc degeneration (DD) or low-back pain (LBP)...

Research Grants70

  1. Bone-Specific Assessment of Marrow Cellularity by H-NMR Spectroscopy
    JOSE CARLOS PICHARDO; Fiscal Year: 2010
    ..Their accuracy has been demonstrated in phantom studies and in vivo for the iliac bone, lumbar vertebrae, femoral head, and proximal end of the tibia...
  2. Age-related Changes in Thoracic Spine Biomechanics
    Dennis Anderson; Fiscal Year: 2013
    ..kyphosis on estimated vertebral loading, to determine if loading is increased in the mid-thoracic and thoraco-lumbar vertebrae. The data collected in these studies, including in vivo measurements of thoracic vertebral kinematics from an ..
  3. Clinical Bone Mechanics Using HR-pQCT and MRI
    Felix W Wehrli; Fiscal Year: 2013
    ..Specific Aim 2a: Perform 5CT scans of lumbar vertebrae from the same subjects as the distal tibia and radius used in Aims 1a and 1b Specific Aim 2b: Compare ..
  4. ESTROGEN REGULATION OF HUMAN INTERLEUKIN 6 GENE PROMOTER
    Sreenivas Koka; Fiscal Year: 1999
    ..age of 50 (post-menopausal) will have bone loss (osteoporosis) so severe that spontaneous fractures of the lumbar vertebrae, hip, or wrist will occur...
  5. BIOMECHANICS OF VERTEBRAL FRACTURES IN OSTEOPOROSIS
    WHITSON EDWARDS; Fiscal Year: 1991
    ..data obtained from fresh cadaver lumbar spine segments and from QCT measurements will be used in models of lumbar vertebrae. We will consider variations in density, material properties and geometry to examine the interactions between ..
  6. EFFECTS OF AGING AND EXERCISE ON BONE MASS
    Coralease Ruff; Fiscal Year: 1992
    ..Using these techniques, bone mineral content of the distal and midshaft femur, lumbar vertebrae, and mandible-maxillae, and cortical geometry of the midshaft femur will be determined 12 months prior to ..
  7. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    James Brindle; Fiscal Year: 2005
    ..g., lumbar vertebrae, and pelvis, etc.)
  8. Z Joint Changes in Low Back Pain Following Adjusting
    Gregory Cramer; Fiscal Year: 2009
    ..The results of this study will be used to increase understanding of the mechanism of action of lumbar side posture adjusting and side-posture positioning in acute LBP patients. ..
  9. BONE DENSITY AND FOREARM FRACTURES IN INJURED CHILDREN
    Heidi Kalkwarf; Fiscal Year: 2002
    ..Understanding the determinants of this measurement will inform strategies to promote healthy bone and decrease fracture risk in childhood. ..
  10. Complications of Surgery for Spinal Stenosis: A Clinical Prediction Rule
    Richard A Deyo; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: A new method for estimating surgical risk will improve patient safety and assist in surgical decision-making, informed consent, monitoring surgical products, &improving quality assessment. ..
  11. Paraspinal Denervation in Low Back Pain
    Andrew J Haig; Fiscal Year: 2010
    ..The results will help doctors avoid unnecessary surgery and help scientists to understand more about how spinal stenosis disables so many older people. ..
  12. Aerobic Exercise, Diet and Cholesterol: A Meta-Analysis
    George A Kelley; Fiscal Year: 2010
    ..This is important since one of the major goals of the Department of Health and Human Services is to increase the quality and years of healthy life. ..
  13. EXERCISE AND BLOOD PRESSURE IN CHILDREN: A META-ANALYSIS
    George Kelley; Fiscal Year: 2001
    ..The investigators state that the results of this project will provide clarification regarding the role of exercise in reducing resting systolic and diastolic blood pressure in children and adolescents. ..
  14. PARASPINAL MUSCLE DENERVATION AND SYMPTOMS IN LUMBAR SS
    Andrew Haig; Fiscal Year: 2005
    ..Subjects will repeat the test battery (MRI, EMG, and clinical evaluation) approximately 18 months later. Appropriate statistics will test each of the four hypotheses. ..
  15. LOW BACK PAIN IN CYCLIC AND PROLONGED ACTIVITIES
    Moshe Solomonow; Fiscal Year: 2002
    ....
  16. Physiology of Cumulative Low Back Disorders
    Moshe Solomonow; Fiscal Year: 2007
    ..abstract_text> ..
  17. The Mechanism and Function of Lumbosacral Orthoses
    Jacek Cholewicki; Fiscal Year: 2006
    ..In addition, data generated from the proposed research will also carry-over into advancing our understanding of the mechanisms and function of ergonomic lumbar supports. ..
  18. BIOMECHANICAL/PSYCHOSOCIAL RISKS FOR LOW BACK DISORDERS
    William Marras; Fiscal Year: 2003
    ..We will also be able to discern when and under what conditions an intervention to improve the psycho social work environment will be likely to reduce LBP and its associated morbidity. ..
  19. EFFECT OF POTASSIUM BICARBONATE ON BONE AND MUSCLE
    Bess Dawson Hughes; Fiscal Year: 2008
    ....
  20. Motor Control Deficit in Low Back Pain: Cause or Effect?
    Jacek Cholewicki; Fiscal Year: 2003
    ..The results of the proposed research will have a significant clinical relevance for designing more effective prevention, diagnosis, and rehabilitation strategies for LBP. ..
  21. MUSCLE OVEREXERTION DURING REPETITIVE LIFTING
    William Marras; Fiscal Year: 2003
    ..These results will provide quantitative guidance for the mediation of work-related LBDs for the millions of workers performing materials handling tasks in manufacturing and distribution center environments. ..
  22. Progressive scoliosis deformity in intervertebral disc
    Ian Stokes; Fiscal Year: 2009
    ..These approaches may include improvements in brace design, new possibilities for muscle rehabilitation, and surgical procedures aimed at early, minimally invasive modification of spinal growth. ..
  23. Bone-Sparing by Ca Salts With & Without Extra Phosphorus
    Robert Heaney; Fiscal Year: 2008
    ..1 Description, ..
  24. Genetic Analysis of Bone Structure and Strength
    Charles Turner; Fiscal Year: 2008
    ..abstract_text> ..
  25. Integrating Automated Mesh Development into the NA-MIC Toolkit
    Nicole Grosland; Fiscal Year: 2009
    ....
  26. NIH OSTEOPOROSIS & RELATED BONE DISEASES RESOURCE CENTER
    Bess Dawson Hughes; Fiscal Year: 2002
    ..Specific efforts include supporting the National Osteoporosis Data Group, collecting and disseminating definitive statistics on bone diseases and on conditions co-morbid with osteoporosis, and preparing summary reports. ..
  27. Biosignatures Classifying Binge Alcohol-Induced Bone Damage and Drug Intervention
    John Callaci; Fiscal Year: 2009
    ....
  28. Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease
    Hoon Ryu; Fiscal Year: 2009
    ..These studies will provide novel mechanisms for preventing mitochondrial transcriptional dysfunction and help in the design of applicable compounds that modulate mitochondrial function. ..
  29. Young Investigators Initiative Workshop (U13)
    Nancy Lane; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  30. Trial of Asthma Patient Education in the Emergency Room
    Carol Mancuso; Fiscal Year: 2009
    ..Other long-term objectives are to use the program as a basis for similar programs for children, adolescents and their caregivers in the ED, primary care, and school settings. ..
  31. Comparison of Aerobic and Resistance Exercise in Older Breast Cancer Survivors
    Kerri Winters Stone; Fiscal Year: 2009
    ..S. "baby boom"population ages. Even so, studies of older women comprise only a small proportion of research, especially exercise research, on improving the lives of cancer survivors. ..
  32. The Epidemiology and Genetics of Hip OA in Elderly Men
    Nancy Lane; Fiscal Year: 2009
    ..After determining the prevalence of hip OA in the Mr. OS cohort we will perform case-control studies of candidate genes associated with bone and cartilage metabolism. ..
  33. BONY EFFECTS OF TRANSIENT NONSKELETAL ILLNESS
    Robert Heaney; Fiscal Year: 2001
    ....
  34. BIOMECHANICAL EFFECT OF ACUPUNCTURE NEEDLING
    HELENE LANGEVIN; Fiscal Year: 2001
    ..This will contribute to the fundamental understanding of acupuncture therapy and may lead to improvements in treatments. ..
  35. Soft Tissue Biomechanical Behavior During Acupuncture in Low Back Pain
    Helene M Langevin; Fiscal Year: 2010
    ....
  36. Image Overlay for MRI-Guided Needle Insertions
    JOHN ANTHONY CARRINO; Fiscal Year: 2010
    ..It can also reduce variability among practitioners, facilitate training, and serve as a research validation tool by providing precisely placed minimally invasive percutaneous conduit under MR guidance. ..
  37. Ventricular Size and Valve Calcification Measures by CT
    Matthew J Budoff; Fiscal Year: 2010
    ..abstract_text> ..
  38. STABILITY OF MUSCULAR LOADING OF THE LUMBAR SPINE
    Ian Stokes; Fiscal Year: 2002
    ..In addition, the specific roles of individual muscles will be better elucidated, which will be helpful in guiding therapy for people with low back dysfunction. ..
  39. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2007
    ..We will quantify the relations between the hormone and genetic exposures measured in this project and mammographic density (at baseline as well as change in density between baseline and 12 months). ..
  40. MULTIAXIAL STRENGTH BEHAVIOR OF HUMAN TRABECULAR BONE
    Tony M Keaveny; Fiscal Year: 2010
    ..This project should provide substantial insight into the roles of trabecular bone strength and bone quality on osteoporotic fracture risk and treatment and other orthopedic applications. ..
  41. Impact of Gait Analysis on Surgical Outcomes
    Tishya Wren; Fiscal Year: 2009
    ..The results will determine whether the use of gait analysis testing improves clinical outcomes in children who have walking problems due to cerebral palsy. ..
  42. CAN PTH REVERSE GLUCOCORTICOID INDUCED OSTEOPOROSIS
    Nancy Lane; Fiscal Year: 2002
    ....
  43. Prevention of Neck Injuries in Older Adults During Rear Motor Vehicle Collsions
    PAUL IVANCIC; Fiscal Year: 2009
    ..The proposed project will provide important research-based data that may form the basis for future safety standards and help to decrease the frequency and severity of neck injuries in older adults, thus benefiting society. ..
  44. CONTROL OF SPINAL LOCOMOTOR ACTIVITY BY MONOAMINES
    BRIAN NOGA; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  45. Bone Strength Phenotypes in men: Genes and Environment
    Joseph Zmuda; Fiscal Year: 2008
    ..The improved understanding of the genetic regulation of bone strength that will emerge from the proposed project will yield fundamental insight into the basic mechanisms of male osteoporosis. ..
  46. ALTERED ETHANOL EFFECTS ON OSTEOCALCIN NULL MUTANT MICE
    Patricia Patterson Buckendahl; Fiscal Year: 2006
    ....
  47. Telomere Length as a Marker of Cardiovascular Aging
    Ellen Demerath; Fiscal Year: 2005
    ..Telomeric DNA length may thus be found to be a valuable plasma biomarker for the prediction and monitoring of cardiovascular health and aging. ..
  48. Mechanical Intervention in Children with Cerebral Palsy
    Tishya Wren; Fiscal Year: 2005
    ..This study will also provide insight into the potential role of muscle adaptation and bone turnover in increasing bone mass in response to this simple, non-invasive, non-pharmacalogical intervention. ..
  49. Determinants of Bone Strength in Afro-Caribbean Families
    Joseph Zmuda; Fiscal Year: 2004
    ..The identification of these genes will likely yield fundamental insight on bone biology and may lead to the development of novel approaches to the diagnosis, treatment, and prevention of osteoporosis. ..
  50. Debonding Strength of Cement Lines in Cortical Bone
    X Guo; Fiscal Year: 2004
    ..Thus, the outcomes from this research will provide new insights that will contribute to our general understanding of the etiology of osteoporotic fractures, and may lead to new perspectives and research in bone tissue quality. ..
  51. Functional Health CAT in Diabetes
    Carolyn Schwartz; Fiscal Year: 2004
    ..abstract_text> ..
  52. INTERDISCIPLINARY RESEARCH PROGRAM FOR UNDERGRADUATES
    Clinton Rubin; Fiscal Year: 2004
    ..Indeed, it is hoped that the most successful of these students will enter our own graduate training programs in the biomedical sciences. ..
  53. PTH STIMULATED BONE FORMATION
    ROBERT JILKA; Fiscal Year: 2004
    ..abstract_text> ..
  54. VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
    Neil Binkley; Fiscal Year: 2003
    ..abstract_text> ..
  55. MECHANICAL MODULATION OF GROWTH IN PHYSES
    Ian Stokes; Fiscal Year: 2003
    ..abstract_text> ..
  56. EXERCISE AND CALCIUM EFFECT ON PUBERTAL BONE GAIN
    Joan Lappe; Fiscal Year: 2006
    ..If these findings hold, they would provide strong support for the essential role of calcium in addition to exercise in maximizing bone mass in growing females. ..
  57. Automating Patient-Specific Model Development
    Nicole Grosland; Fiscal Year: 2006
    ..abstract_text> ..
  58. A Data Fusion Method for Bedside Monitoring of Lumped Cerebral Arterial Radii
    Xiao Hu; Fiscal Year: 2008
    ..abstract_text> ..
  59. NEUROPHYSIOLOGY OF CRANIAL HEADACHE
    Andrew Strassman; Fiscal Year: 2008
    ..This information can then be used to develop strategies for blocking the neural changes that result in headache. [unreadable] [unreadable]..
  60. Small Grant Program for Conference Support (R13)
    Nancy Lane; Fiscal Year: 2007
    ..To review the issues they need to address to fully develop their submissions, if participants have not yet submitted proposals. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  61. Mechanotransduction in Osteocytic Network and Osteoblast
    X Guo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  62. The Yoga for Hyperkyphosis Trial
    Gail Greendale; Fiscal Year: 2007
    ..At the end of this phase we will again measure study endpoints to assess whether participants have maintained the physical function achieved at the end of the RCT. ..
  63. ENDOCRINE CHANGES AND TREATMENT OF CONDUCT PROBLEMS
    LORAH DORN; Fiscal Year: 2007
    ..We anticipate that findings will contribute to further understanding of the neurophysiology of conduct problems in youth. ..
  64. Biomechanics of Spine Fracture
    TONY KEAVENY; Fiscal Year: 2007
    ..abstract_text> ..
  65. Development of a Spinal Intervertebral Disc Prosthesis
    GLENN BUTTERMANN; Fiscal Year: 2003
    ..The objective of Phase I is to demonstrate that the device restores normal spine biomechanics (range of motion and stiffness) and is durable in fatigue testing. ..
  66. Diabetic/osmotic Influences on Osteoblast Phenotype
    Laura McCabe; Fiscal Year: 2007
    ..Our results will suggest targets for ameliorating the effects of type I diabetes on bone. [unreadable] [unreadable]..
  67. Calcium Foods and Bone Health of Adolescent Girls
    Joan Lappe; Fiscal Year: 2007
    ..Lack of a calcium effect would provide support for further research into other methods or concomitant methods of maximizing skeletal development. ..
  68. CALCIUM AND VITAMIN D MALNUTRITION IN ELDERLY WOMEN
    Joan Lappe; Fiscal Year: 2003
    ..This is a valid method to determine compliance, far superior to the traditional pill counts, and thus a substantial aid to measure the anti-fracture efficacy of calcium alone or calcium plus vitamin D interventions. ..
  69. SPINAL BENDING MOTIONS FOR PREVENTING DISC DEGENERATION
    Adam Hsieh; Fiscal Year: 2003
    ..These regimens will then be tested experimentally to determine the effects on biosynthesis and apoptosis. ..