Top Publications

  1. ncbi Agenesis of the posterior arch of the atlas
    Martin Torriani
    Department of Radiology, School of Medicine, University of Campinas, Brazil
    Rev Hosp Clin Fac Med Sao Paulo 57:73-6. 2002
  2. ncbi Gross morphology of the bridges over the vertebral artery groove on the atlas
    George Paraskevas
    Department of Anatomy, Faculty of Medicine, Aristotle University of Salonica, Salonica, Greece
    Surg Radiol Anat 27:129-36. 2005
  3. ncbi Occipitalization of the atlas in children. Morphologic classification, associations, and clinical relevance
    Purushottam A Gholve
    Division of Orthopaedic Surgery, Children s Hospital of Philadelphia, 2nd Floor, Wood Building, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Bone Joint Surg Am 89:571-8. 2007
  4. pmc Coincidental deficiency of the posterior arch of the atlas and thalassaemia minor: possible pitfalls in a trauma victim
    M H Schrödel
    KH Munich Harlaching, Sanatoriumsplatz 2, Munich, 81545, Germany
    Emerg Med J 22:526-8. 2005
  5. ncbi Why Atlas, why not Heracles: reflections on the rheumatoid cervical spine
    Kari Laiho
    Rheumatism Foundation Hospital, Heinola, Finland
    Semin Arthritis Rheum 34:637-41. 2005
  6. ncbi Painful osteolytic metastasis of the atlas: treatment with percutaneous vertebroplasty
    Stephan G Wetzel
    Department of Radiology at the University Hospital of Geneva, Geneva, Switzerland
    Spine (Phila Pa 1976) 27:E493-5. 2002
  7. ncbi Posterior arch defects of the atlas: significance in trauma and literature review
    Soham Gangopadhyay
    Southend Hospital, Prittlewell Chase, Westcliff on Sea, Essex SS0 0RY, UK
    Eur J Emerg Med 10:238-40. 2003
  8. ncbi Lhermitte sign during yawning associated with congenital partial aplasia of the posterior arch of the atlas
    T Sagiuchi
    Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    AJNR Am J Neuroradiol 27:258-60. 2006
  9. ncbi Anteroposterior spondyloschisis of the atlas. Two case reports and literature review
    Senthil Kumar Muthu
    Department of Radiology, Hammersmith Hospital NHS Trust, Duncan Road, London W12 0HS, UK
    Emerg Radiol 13:337-40. 2007
  10. pmc Occult congenital anomaly of the atlas presenting in the setting of acute trauma
    A W O'Sullivan
    National Spinal Injuries Unit, Mater Misericordiae Hospital, Dublin, Ireland
    Emerg Med J 21:639-40. 2004

Research Grants

Detail Information

Publications237 found, 100 shown here

  1. ncbi Agenesis of the posterior arch of the atlas
    Martin Torriani
    Department of Radiology, School of Medicine, University of Campinas, Brazil
    Rev Hosp Clin Fac Med Sao Paulo 57:73-6. 2002
    To illustrate the radiological findings and review the current literature concerning a rare congenital abnormality of the posterior arch of the atlas.
  2. ncbi Gross morphology of the bridges over the vertebral artery groove on the atlas
    George Paraskevas
    Department of Anatomy, Faculty of Medicine, Aristotle University of Salonica, Salonica, Greece
    Surg Radiol Anat 27:129-36. 2005
    The bony bridges of the atlas over the "groove of the vertebral artery" are commonly seen in plain radiographs of the cervical spine, and it is a subject of controversy whether they cause compression of the underneath lying vertebral ..
  3. ncbi Occipitalization of the atlas in children. Morphologic classification, associations, and clinical relevance
    Purushottam A Gholve
    Division of Orthopaedic Surgery, Children s Hospital of Philadelphia, 2nd Floor, Wood Building, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Bone Joint Surg Am 89:571-8. 2007
    Occipitalization is defined as a congenital fusion of the atlas to the base of the occiput...
  4. pmc Coincidental deficiency of the posterior arch of the atlas and thalassaemia minor: possible pitfalls in a trauma victim
    M H Schrödel
    KH Munich Harlaching, Sanatoriumsplatz 2, Munich, 81545, Germany
    Emerg Med J 22:526-8. 2005
    ..Deficiency of the posterior arch of the atlas and coincidental thalassaemia minor are even more unusual...
  5. ncbi Why Atlas, why not Heracles: reflections on the rheumatoid cervical spine
    Kari Laiho
    Rheumatism Foundation Hospital, Heinola, Finland
    Semin Arthritis Rheum 34:637-41. 2005
    ..A central role in these disorders is played by a small-size, heavy-duty fitting piece or adapter, atlas, between the occiput and C2...
  6. ncbi Painful osteolytic metastasis of the atlas: treatment with percutaneous vertebroplasty
    Stephan G Wetzel
    Department of Radiology at the University Hospital of Geneva, Geneva, Switzerland
    Spine (Phila Pa 1976) 27:E493-5. 2002
    ..Technical note...
  7. ncbi Posterior arch defects of the atlas: significance in trauma and literature review
    Soham Gangopadhyay
    Southend Hospital, Prittlewell Chase, Westcliff on Sea, Essex SS0 0RY, UK
    Eur J Emerg Med 10:238-40. 2003
    Neck pain and stiffness after trauma can be caused by congenital defects in the posterior arch of the atlas. A case is described followed by a description of the pathology, classification, diagnosis and treatment of such defects...
  8. ncbi Lhermitte sign during yawning associated with congenital partial aplasia of the posterior arch of the atlas
    T Sagiuchi
    Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    AJNR Am J Neuroradiol 27:258-60. 2006
    ..It was associated with congenital partial aplasia of the posterior arch of the atlas. Cervical multisection-detector CT myelography during yawning showed compression of the upper cervical cord due to ..
  9. ncbi Anteroposterior spondyloschisis of the atlas. Two case reports and literature review
    Senthil Kumar Muthu
    Department of Radiology, Hammersmith Hospital NHS Trust, Duncan Road, London W12 0HS, UK
    Emerg Radiol 13:337-40. 2007
    Congenital bony defects of the atlas are uncommon; with isolated posterior clefts being the most frequent anomaly and combined anterior and posterior defects the least common, occurring in only 0.3-0.7% of the population...
  10. pmc Occult congenital anomaly of the atlas presenting in the setting of acute trauma
    A W O'Sullivan
    National Spinal Injuries Unit, Mater Misericordiae Hospital, Dublin, Ireland
    Emerg Med J 21:639-40. 2004
    Congenital absence of the posterior arch of the atlas is rare. Its detection in the setting of acute trauma may be confusing and mimic a fracture. This case serves to highlight the adjunctive use of computed tomography in equivocal cases...
  11. ncbi A congenital anomaly of the atlas as a diagnostic dilemma: a case report
    Annemarie de Zoete
    Praktijk Chiropractie Heiloo, Kennemerstraatweg 69, 1851 BB Heiloo, The Netherlands
    J Manipulative Physiol Ther 30:62-4. 2007
    The purpose of this case report is to draw attention to the differences between a Jefferson fracture and a congenital anomaly of the anterior and/or the posterior arch of the atlas.
  12. ncbi Congenital partial aplasia of the posterior arch of the atlas causing myelopathy: case report and review of the literature
    Paul Klimo
    Department of Neurosurgery, University of Utah, Salt Lake City 84132 2303, USA
    Spine (Phila Pa 1976) 28:E224-8. 2003
    A case report of a patient with a congenital anomaly of the posterior arch of the atlas and review of the literature are reported.
  13. pmc A case of Collet-Sicard syndrome associated with traumatic atlas fractures and congenital basilar invagination
    H P Hsu
    Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University, 199 Tun Hwa North Road, Taipei, Taiwan 10591
    J Neurol Neurosurg Psychiatry 75:782-4. 2004
    ..Computed tomography of his skull base revealed a two part atlas Jefferson fracture...
  14. ncbi Atlas vertebra realignment and achievement of arterial pressure goal in hypertensive patients: a pilot study
    G Bakris
    Department of Preventive Medicine, Rush University Hypertension Center, Chicago, IL, USA
    J Hum Hypertens 21:347-52. 2007
    Anatomical abnormalities of the cervical spine at the level of the Atlas vertebra are associated with relative ischaemia of the brainstem circulation and increased blood pressure (BP)...
  15. ncbi Anterior atlas fracture following suboccipital decompression for Chiari I malformation. Report of two cases
    Brian A O'Shaughnessy
    Department of Neurological Surgery, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Neurosurg Spine 1:137-40. 2004
    ..A C-1 fracture should therefore be considered in the differential diagnosis of posterior cervical pain in patients who have previously undergone decompression for Chiari I malformation...
  16. ncbi Cervical myelopathy caused by hypoplasia of the atlas and ossification of the transverse ligament--case report
    Wataro Tsuruta
    Neurosurgery Division, Kitaibaraki Municipal Hospital, Kitaibaraki, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 43:55-9. 2003
    ..Japanese female presented with symptomatic cervical myelopathy caused by a hypoplastic posterior arch of the atlas and ossification of the transverse ligament...
  17. ncbi Arcuate foramen of atlas: incidence, phylogenetic and clinical significance
    A Krishnamurthy
    Department of Anatomy, Kasturba Medical College, Center for Basic Sciences, Bejai, Mangalore, Karnataka, India
    Rom J Morphol Embryol 48:263-6. 2007
    Arcuate foramen is less known trait of the human atlas vertebra formed by a delicate bony spiculum, which arches backward from the posterior end of the superior articular process...
  18. pmc JAtlasView: a Java atlas-viewer for browsing biomedical 3D images and atlases
    Guangjie Feng
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, UK
    BMC Bioinformatics 6:47. 2005
    ..Here we discuss an atlas viewer implemented to run on any workstation using the architecture neutral Java programming language.
  19. ncbi The frequency and clinical significance of congenital defects of the posterior and anterior arch of the atlas
    Mehmet Senoglu
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosurg Spine 7:399-402. 2007
    ..In this study the authors investigated the anatomical, clinical, and imaging features as well as incidence of congenital defects of the C-1 arch...
  20. ncbi Cervical spinal stenosis and myelopathy due to atlas hypoplasia
    Yu Hone Hsu
    Division of Neurosurgery, Department of Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan, R O C
    J Chin Med Assoc 70:339-44. 2007
    ..a patient who presented at our hospital with neurologic symptoms due to congenital cervical spinal stenosis at the atlas level. Congenital atlantal stenosis is usually due to hypoplasia of the posterior arch of the atlas...
  21. ncbi Bipartite atlas with os odontoideum: case report
    Ajay Garg
    Department of Neuroradiology, All India Institute of Medical Sciences, New Delhi, India
    Spine (Phila Pa 1976) 29:E35-8. 2004
    A case report of bipartite atlas associated with os odontoideum and review of the pertinent literature are presented.
  22. ncbi Comparison of atlas- and magnetic resonance imaging-based stereotactic targeting of the globus pallidus internus in the performance of deep brain stimulation for treatment of dystonia
    Nathalie Vayssiere
    Department of Pediatric Neurosurgery Research Group on Movement Disorders in Children, University Hospital, Montpellier, France
    J Neurosurg 96:673-9. 2002
    ..coordinates in the globus pallidus internus (GPi) obtained using magnetic resonance (MR) imaging with those determined using an atlas. The targets were used in deep brain stimulation (DBS) for the treatment of generalized dystonia.
  23. ncbi Calcium pyrophosphate dihydrate deposition in the transverse ligament of the atlas: an unusual cause of cervical myelopathy
    M Doita
    Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Skeletal Radiol 36:699-702. 2007
    ..The preoperative differential diagnosis of periodontoid CPPD deposition disease in the elderly population should be considered, particularly if CT studies demonstrate small areas of calcification within the retro-odontoid mass...
  24. ncbi Management of acute traumatic atlas fractures
    Egidijus Kontautas
    Department of Orthopaedics and Traumatology, Kaunas University of Medicine Hospital, Kaunas, Lithuania
    J Spinal Disord Tech 18:402-5. 2005
    A prospective review of a clinical series was performed. The treatment features of atlas fractures with and without associated axis injuries were investigated.
  25. ncbi A rare cause of cervical spinal stenosis: posterior arch hypoplasia in a bipartite atlas
    C Atasoy
    Emek, Kirim Caddesi, Senyuva Sitesi, Ankara, Turkey
    Neuroradiology 44:253-5. 2002
    ..previously unreported combination of atlantoaxial anomalies consisting of posterior arch hypoplasia in a bipartite atlas with an os odontoideum, in a 30-year-old woman presenting with neck and left arm pain...
  26. ncbi Chiropractic care of a patient with temporomandibular disorder and atlas subluxation
    Joel Alcantara
    Research Associate, Gonstead Clinical Studies Society, Santa Cruz, Calif, USA
    J Manipulative Physiol Ther 25:63-70. 2002
    ..To describe the chiropractic care of a patient with cervical subluxation and complaints associated with temporomandibular disorder...
  27. pmc Persistent torticollis, facial asymmetry, grooved tongue, and dolicho-odontoid process in connection with atlas malformation complex in three family subjects
    Ali Al Kaissi
    Osteology research, Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Heinrich Collin Str 30, 1140, Vienna, Austria
    Eur Spine J 16:265-70. 2007
    Congenital clefts and other malformations of the atlas are incidental findings identified while investigating the cervical spine following trauma...
  28. ncbi Evaluation of cervical posture of children in skeletal class I, II, and III
    Michele D'Attilio
    Department of Orthodontics, University of Chieti, Italy
    Cranio 23:219-28. 2005
    ..The posture of the neck seems to be strongly associated with the sagittal as well as the vertical structure of the face...
  29. ncbi Cervical angina caused by atlantoaxial instability
    Yoshiyuki Ito
    Department of Orthopaedic Surgery, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Spinal Disord Tech 17:462-5. 2004
    ..Cervical angina due to atlantoaxial instability is one of the differential diagnoses of precordialgia...
  30. ncbi Does head posture have a significant effect on the hyoid bone position and sternocleidomastoid electromyographic activity in young adults?
    Saúl Valenzuela
    Oral Physiology Laboratory, Biomedical Sciences Institute, Faculty of Medicine, University of Chile, Santiago
    Cranio 23:204-11. 2005
    ..There was no association to head posture with/without the condition of CMD. Clinical relevance of the results is discussed...
  31. ncbi Accessory joints between basiocciput and atlas/axis in the median plane
    M Von Lüdinghausen
    Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    Clin Anat 18:558-71. 2005
    ..the many osseous irregularities that are found in the area between the basiocciput, the anterior arch of the atlas and the tip of the dens axis we studied 99 cadaver specimens using magnetic resonance tomography (MRT), computed ..
  32. ncbi Principal components analysis of the atlas vertebra
    Christopher A Meseke
    Academic Affairs, Palmer College of Chiropractic, Florida Campus, Port Orange, Fla 32129, USA
    J Manipulative Physiol Ther 31:212-6. 2008
    This project explored morphological asymmetry of the atlas by comparing multiple structural variables bilaterally using multivariate statistics.
  33. ncbi Vertical atlantoaxial index: a new craniovertebral radiographic index
    Arvind G Kulkarni
    Department of Neurosurgery, KEM Hospital and Seth GS Medical College, Mumbai, India
    J Spinal Disord Tech 21:4-10. 2008
    An index for measuring the vertical relationship of atlas and axis is described.
  34. ncbi Analysis of anatomical variations of bone and vascular structures around the posterior atlantal arch using three-dimensional computed tomography angiography
    Jae Taek Hong
    Department of Neurosurgery, Catholic University of Korea, St Vincent s Hospital, Suwon, Republic of Korea
    J Neurosurg Spine 8:230-6. 2008
    ..incidence of anatomical variations of the V(3) segment of the vertebral artery (VA) and the posterior arch of the atlas (C-1)...
  35. ncbi Mobile and reducible atlantoaxial dislocation in presence of occipitalized atlas: report on treatment of eight cases by direct lateral mass plate and screw fixation
    Atul Goel
    Department of Neurosurgery, K E M Hospital and Seth G S Medical College, Mumbai, India
    Spine (Phila Pa 1976) 29:E520-3. 2004 on the application of the authors' technique of atlantoaxial lateral mass plate and screw fixation on a rare subset of patients having mobile and reducible atlantoaxial subluxation in the presence of occipitalized atlas.
  36. ncbi Odontoid compression of the brainstem without basilar impression-- "odontoid invagination"
    Kazuhiko Kyoshima
    Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan
    J Clin Neurosci 12:565-9. 2005
    ..Decompression of the neuraxis together with symptomatic improvement was achieved in all patients and none became unstable or developed new symptoms during follow-up ranging from 3 to 15 years...
  37. ncbi Posterolateral dislocation of the C1-C2 articulation associated with fracture of the anterior arch of C1: a case report
    Jason J Howard
    University of Calgary Spine Program, Division of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Spine (Phila Pa 1976) 29:E562-4. 2004
    ..Case report...
  38. ncbi Posterior atlanto-axial arthrodesis for fixation of odontoid nonunions
    Patrick Platzer
    Department of Traumatology, Medical University of Vienna, Waehringer Guertel, Vienna, Austria
    Spine (Phila Pa 1976) 33:624-30. 2008
    ..A retrospective case series...
  39. ncbi Tectorial membrane injuries in children
    Frances A Farley
    Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA
    J Spinal Disord Tech 18:136-8. 2005
    ..Two children with partial tears of the tectorial membrane were immobilized in a halo, and one with a longitudinal tear of the tectorial membrane had an occiput-to-C2 fusion...
  40. ncbi [Experimental study of posterior pedicle screw placement on atlas]
    Xiangyang Ma
    Department of Orthopaedic Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou Guangdong 510010, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:392-5. 2004
    To assess the possibility of placing the posterior pedicle screw on atlas.
  41. ncbi Frameless stereotactic image-guided C1-C2 transarticular screw fixation for atlantoaxial instability: review of 20 patients
    Frank L Acosta
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143 0112, USA
    J Spinal Disord Tech 18:385-91. 2005
    ..We retrospectively studied 20 adults who underwent C1-C2 transarticular screw (TAS) fixation utilizing frameless stereotaxy...
  42. pmc Os odontoideum with bipartite atlas and segmental instability: a case report
    Michael Osti
    Academic Hospital Feldkirch, Trauma Surgery and Sports Traumatology, Feldkirch, Austria
    Eur Spine J 15:564-7. 2006
    ..cord signal at C1/C2 levels caused by an os odontoideum, as well as anterior and posterior arch defects of the atlas. The patient underwent closed reduction and posterior atlantoaxial fusion...
  43. ncbi Atlantoaxial subluxation-induced myelopathy in cleidocranial dysplasia. Case report
    Shigeru Kobayashi
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University School of Medicine, Fukui, Japan
    J Neurosurg Spine 7:243-7. 2007
    ..Surgery was performed twice for cervical myelopathy and atlantoaxial subluxation, including laminectomy at the atlas and cervicooccipital fusion in which the Luque rod system was used, as well as C1-2 fusion via the transpharyngeal ..
  44. ncbi Atlantoaxial stabilization with the use of C1-3 lateral mass screw fixation. Technical note
    Eric M Horn
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosurg Spine 5:172-7. 2006
    ..In this series of 10 patients, the method was a safe and effective way to provide stabilization in these anatomically difficult patients...
  45. ncbi Halo traction in basilar invagination: technical case report
    Serkan Simsek
    Neurosurgery Department, Ministry of Health, Diskapi Educational and Research Hospital, Ankara 06110, Turkey
    Surg Neurol 66:311-4; discussion 314. 2006
    ..We aimed to discuss the role of the halo vest apparatus traction on the reduction of severe anterior compression pathologies in basilar invagination...
  46. ncbi Craniovertebral tuberculosis: a retrospective review of 13 cases managed conservatively
    Manish Chadha
    Department of Orthopedics, UCMS and GTB Hospital, Delhi, India
    Spine (Phila Pa 1976) 32:1629-34. 2007
    ..Retrospective review of 13 cases with craniovertebral tuberculosis treated conservatively...
  47. ncbi Biomechanical comparison of C1-C2 posterior arthrodesis techniques
    Panayiotis J Papagelopoulos
    First Department of Orthopaedics, Athens University Medical School, Athens, Greece
    Spine (Phila Pa 1976) 32:E363-70. 2007
    ..Biomechanical comparison of 5 atlantoaxial posterior arthrodesis techniques...
  48. ncbi Atlantoaxial fusion: a biomechanical analysis of two C1-C2 fusion techniques
    Roderick Claybrooks
    Spine Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Spine J 7:682-8. 2007
    ..Recently, C1 lateral mass to C2 laminar (C1LM-C2L) fixation has been shown to have flexibility similar to C1LM-C2P fixation in flexion, extension, lateral bending, and axial rotation...
  49. ncbi Intra-operative Iso-C3D navigation for pedicle screw instrumentation of hangman's fracture: a case report
    S Rajasekaran
    Department of Orthopaedics and Spine Surgery, Ganga Hospital, Coimbatore, Tamil Nadu, India
    J Orthop Surg (Hong Kong) 15:73-7. 2007
    ..The navigation system has the advantage of data acquisition after patient positioning, thus making safe pedicle fixation of the C1 and C2 vertebrae possible despite fractured posterior elements...
  50. ncbi Double insurance atlantoaxial fixation
    Atul Goel
    Department of Neurosurgery, King Edward VII Memorial Hospital, Mumbai 400012, India
    Surg Neurol 67:135-9. 2007
    ..An alternative technique of atlantoaxial fixation is described, which combines the trans-articular method of fixation described by Magerl in 1982 and the interarticular technique described by us in 1988...
  51. ncbi The expanded endonasal approach for an endoscopic transnasal clipping and aneurysmorrhaphy of a large vertebral artery aneurysm: technical case report
    Amin B Kassam
    Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Neurosurgery 59:ONSE162-5; discussion ONSE162-5. 2006
    ..Recent advances in endoscopic transnasal surgery have provided an additional approach for the treatment of these difficult lesions...
  52. ncbi Bone tumors at the cranio-cervical junction. Surgical management and results from a series of 41 cases
    B George
    Department of Neurosurgery, Hopital Lariboisiere, Paris, France
    Acta Neurochir (Wien) 148:741-9; discussion 749. 2006
    ..The surgical management includes tumoral resection and stabilization of the CCJ...
  53. pmc Screw fixation via diploic bone paralleling to occiput table: anatomical analysis of a new technique and report of 11 cases
    Tan Mingsheng
    China Japan Friendship Hospital, Department of Orthopedic Surgery, Beijing, China
    Eur Spine J 16:2225-31. 2007
    ..The results confirm that occiput is available for holding intraocciput screw paralleling to diploic bone...
  54. ncbi Acute combination fracture of atlas and axis: "triple" anterior screw fixation in a 92-year-old man: technical note
    Umberto Agrillo
    Sandro Pertini Hospital, Division of Neurosurgery, Rome, Italy
    Surg Neurol 65:58-62. 2006
    ..We report a case of combination atlas-type II odontoid fracture that occurred in a 92-year-old man...
  55. ncbi 3D morphometry of the transverse and alar ligaments in the occipito-atlanto-axial complex: an in vitro analysis
    E Cattrysse
    Faculty of Medicine and Pharmacy, and Faculty of Physical Education and Physiotherapy, Department of Experimental Anatomy, Arthrokinematics Research Group, Vrije Universiteit Brussel, Belgium
    Clin Anat 20:892-8. 2007
    ..In 20 fresh spine specimens, metal markers were inserted on the cranium, atlas, and axis...
  56. ncbi Horizontal fracture of the anterior arch of the atlas associated with a congenital cleft of the anterior arch
    Kaoru K Sasaka
    Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, 52242, USA
    Emerg Radiol 12:130-2. 2006
    We report a rare combination of a horizontal fracture of the anterior arch of the atlas associated with a congenital cleft of the anterior arch...
  57. ncbi [Injuries to the craniocervical junction]
    R Kayser
    Zentrum fur spezielle Chirurgie des Bewegungsapparates, Klinik und Hochschulambulanz für Unfall und Wiederherstellungschirurgie, Charite, Campus Benjamin Franklin, Universitatsmedizin Berlin
    Orthopade 35:244-69. 2006
    ..following types of injuries: C0 fractures, occipital condyle fractures (OCF), atlanto-occipital dislocation (AOD), atlas fractures, atlantoaxial dislocation (AAD), and axis fractures...
  58. pmc Anterior retropharyngeal fixation C1-2 for stabilization of atlantoaxial instabilities: study of feasibility, technical description and preliminary results
    Heiko Koller
    Department for Trauma and Reconstructive Surgery, Katharinenhospital, Kriegsbergstrasse 36, Postfach 10 26 44, 70022, Stuttgart, Germany
    Eur Spine J 15:1326-38. 2006
    ..Based on anatomic findings, the technique and its feasibility in daily clinical work is depicted and discussed on our preliminary results in seven patients...
  59. ncbi Palpatory diagnosis of plagiocephaly
    Nicette Sergueef
    Department of Osteopathic Manipulative Medicine, Midwestern University, 555 31st Street, Downers Grove, IL, USA
    Complement Ther Clin Pract 12:101-10. 2006
    ..For these reasons, we decided to look at the mechanics of the occipital bone and the adjacent atlas and bones of the cranial base, in relation to functional plagiocephaly.
  60. ncbi [Reliability of direct probing isthmus of axial vertebrae to defining the screw path in atlas during Magerl technique]
    Ming Yan
    Department of Orthopedics, Peking University Third Hospital, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 86:325-8. 2006
    To evaluate the accuracy and reliability of atlantoaxial transarticular screw insertion (Magerl's technique) in atlas under lateral fluoroscopic monitoring without anteroposterior view.
  61. ncbi Working area, safety zones, and angles of approach for posterior C-1 lateral mass screw placement: a quantitative anatomical and morphometric evaluation
    Rogerio Rocha
    Department of Neurosurgery, Institute of Neurological Sciences, Sao Paulo, Brazil
    J Neurosurg Spine 6:247-54. 2007
    ..The authors measured relevant quantitative anatomical parameters to define safety zones for the placement of C-1 posterior screws...
  62. ncbi Case-control study comparing the efficacy of surgical techniques for C1-C2 arthrodesis
    Derek A Taggard
    Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    J Spinal Disord Tech 17:189-94. 2004
    ..004). This study demonstrated a statistically increased rate of arthrodesis as determined by specific radiographic criteria with the use of TAS fixation as compared with PWT...
  63. ncbi Posterior screw placement on the lateral mass of atlas: an anatomic study
    Xia Hong
    Department of Orthopedics, Liuhua Qiao Hospital of Guangzhou, China
    Spine (Phila Pa 1976) 29:500-3. 2004
    An anatomic study evaluating the feasibility of posterior screw fixation on the lateral mass of the atlas and comparing the pullout force of C1 posterior lateral mass screws with that of occipital and C2 pedicle screws.
  64. ncbi Bony anomalies of the craniocervical junction
    P V V Prasada Rao
    Department of Anatomy, University of Zimbabwe, P O Box MP 167, Harare, Zimbabwe
    Cent Afr J Med 48:17-23. 2002
    ..junction was carried out with emphasis on anomalous manifestations associated with the occipital bone, atlas and axis vertebrae...
  65. ncbi Split atlas in a patient with odontoid fracture
    F Bonneville
    Department of Neuroradiology, Hopital Jean Minjoz, 25000, Besancon, France
    Neuroradiology 46:450-2. 2004
    We report the unusual association of a split atlas and an odontoid fracture in a case of a cervical trauma, thus mimicking a complex C1-C2 fracture. The normal embryology of C1 and the literature on this rare malformation are reviewed.
  66. ncbi Neck injuries among the elderly in Sweden
    Karin Brolin
    Department of Aeronautics, Royal Institute of Technology, Stockholm, Sweden
    Inj Control Saf Promot 10:155-64. 2003
    ..Lower vertebral fractures occurred in 16% of the cases and atlas (C1) fractures in 11%. The cervical soft tissue injuries amount to 19% of all injuries...
  67. ncbi Upper cervical spine injuries
    R Sean Jackson
    Kansas City Bone and Joint Clinic, Kansas City, MO, USA
    J Am Acad Orthop Surg 10:271-80. 2002
    ..Bony injuries, including occipital condyle fractures, atlas fractures, most odontoid fractures, and traumatic spondylolisthesis of the axis, generally respond well to ..
  68. ncbi Morphometric evaluation of screw fixation in atlas via posterior arch and lateral mass
    Mingsheng Tan
    Department of Orthopedics Surgery, China Japan Friendship Hospital, Ministry of Health, Beijing, People s Republic of China
    Spine (Phila Pa 1976) 28:888-95. 2003
    ..This study is a result of manual and radiologic measurements of 50 isolated anatomic specimens of C1 and five patients of atlantoaxial instability treated by screw fixation via posterior arch and lateral mass...
  69. ncbi Recurrent atlantoaxial rotatory fixation in children: a rare complication of a rare condition. Report of four cases
    John E Crossman
    Department of Surgical Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
    J Neurosurg 100:307-11. 2004
    ..The authors believe this technique of joint stabilization augments the strength of the joint, allowing normal, but preventing excessive, rotation, until the joint reaches physiological maturity...
  70. ncbi [Fractures of the atlantoaxial complex in the elderly: assessment of radiological spectrum of fractures and factors influencing imaging diagnosis]
    F M Lomoschitz
    Universitatsklinik fur Radiodiagnostik, AKH Wien, A 1090 Wien
    Rofo 176:222-8. 2004
  71. ncbi Atlantoaxial instability in a white-tailed deer fawn (Odocoileus virginianus)
    Mitchell V Palmer
    Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, USDA, 2300 Dayton Road, Ames, Iowa 50010, USA
    J Wildl Dis 38:860-2. 2002
    ..examination revealed atlantoaxial instability with ventral deviation of the axis due to malformation of the caudal atlas and cranial axis...
  72. ncbi Cadaveric morphometric analysis for atlantal lateral mass screw placement
    Michael Y Wang
    Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Neurosurgery 54:1436-9; discussion 1439-40. 2004
    ..For these reasons, C1 lateral mass screws are becoming increasingly popular. However, the critical local anatomy and unfamiliarity with this new technique can make C1 screw placement more challenging...
  73. pmc Complete arcuate foramen precluding C1 lateral mass screw fixation in a patient with rheumatoid arthritis: case report
    Michael J Huang
    Department of Orthopaedic Surgery, 01022 JPP, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    Iowa Orthop J 23:96-9. 2003
    Case report of a complete arcuate foramen in a human atlas vertebra inhibiting the placement of lateral mass screw instrumentation at C1...
  74. ncbi Vertebral synovial chondromatosis. Report of two cases and review of the literature
    Gary L Gallia
    Departments of Neurosurgery, Pathology, and Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosurg Spine 1:211-8. 2004
  75. ncbi Posterior atlantoaxial fixation: biomechanical in vitro comparison of six different techniques
    Marcus Richter
    Department of Orthopedics and SCI, University of Ulm, Sweden
    Spine (Phila Pa 1976) 27:1724-32. 2002
    ..Six different techniques for atlantoaxial fixation were biomechanically compared in vitro by nondestructive testing...
  76. ncbi Posterior atlanto-axial fusion with the Olerud Cervical Fixation System for odontoid fractures and C1-C2 instability in rheumatoid arthritis
    M Cornefjord
    Department of Orthopaedics, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Eur Spine J 12:91-6. 2003
    ..No serious complications related to the surgical procedure were encountered. The stability of the implant obviates the use of a solid bone block as a graft and still allows a high frequency of fusion healing...
  77. pmc Therapeutic options and results following fixed atlantoaxial rotatory dislocations
    Markus Weisskopf
    Department of Orthopedic Surgery, University Hospital of the RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Eur Spine J 14:61-8. 2005
    ..6 points, while the average length of the DTI was 40.5 months. In conclusion, the clinical outcome and the subjective well-being following AARD deteriorates with increasing length of the dislocation-therapy interval...
  78. pmc Revised nomenclature for avian telencephalon and some related brainstem nuclei
    Anton Reiner
    Department of Anatomy, University of Tennessee Health Science Center, Memphis 38163, USA
    J Comp Neurol 473:377-414. 2004
    ..nucleus had been incorrectly identified as the nucleus intermedius in the Karten and Hodos (1967) pigeon brain atlas, and what was identified as the hypoglossal nucleus in that atlas should instead be called the supraspinal nucleus...
  79. pmc Towards the Atlas of human African trypanosomiasis
    Giuliano Cecchi
    Food and Agriculture Organization of the United Nations, Animal Production and Health Division, Rome, Italy
    Int J Health Geogr 8:15. 2009
    ..We describe input data, methodology, preliminary results and future prospects of the HAT Atlas initiative, which will allow major improvements in the understanding of the spatial distribution of the disease.
  80. ncbi Mandibular condylar fractures and acute atlanto-axial subluxation. Part 1 - A new clinical and nosographic evidence
    T Cutilli
    Department of Maxillofacial Surgery, University of L Aquila School of Medicine, Italy
    Minerva Stomatol 58:187-98. 2009
    ..The aim of this study was to analyze the acute repercussions of condylar mandibular fractures on occipital-atlanto-axial joint...
  81. ncbi Dental students attitudes regarding online education in pediatric dentistry
    Devereaux Peterson
    Department of Pediatric Dentistry, Seattle, Washington, USA
    J Dent Child (Chic) 74:10-20. 2007
    The Atlas of Pediatric Dentistry is a Web-based (Atlas of Pediatric Dentistry Atlas of Pediatric Dentistry (http://depts.washington...
  82. ncbi Multi-season climate synchronized forest fires throughout the 20th century, northern Rockies, U.S.A
    Penelope Morgan
    Department of Forest Resources, University of Idaho, Moscow, Idaho 83844 1133, USA
    Ecology 89:717-28. 2008
    ..S. northern Rockies. We derived annual fire extent from an existing fire atlas that includes 5038 fire polygons recorded from 12,070,086 ha, or 71% of the forested land in Idaho and Montana ..
  83. ncbi Budget and financing of mental health services: baseline information on 89 countries from WHO's project atlas
    Shekhar Saxena
    Mental Health Evidence and Research, Department of Mental Health and Substance Dependence, World Health Organization, CH 1211, Geneva 27, Switzerland
    J Ment Health Policy Econ 6:135-43. 2003
    ..Very little information is available on budget and financing of mental health services in the world...
  84. pmc Design and implementation of an automated partial volume correction in PET: application to dopamine receptor quantification in the normal human striatum
    Olivier G Rousset
    Section of High Resolution Brain PET Imaging, Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Nucl Med 49:1097-106. 2008
    ..reproducibility of human-driven PET quantification and partial volume correction (PVC) can be alleviated by use of atlas-based automatic analysis...
  85. ncbi PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease
    Hiroshi Toyama
    Department of Radiology, Fujita Health University, 1 98, Dengakugakubo, Kutsukake, Toyoake, 470 1192, Aichi, Japan
    Eur J Nucl Med Mol Imaging 32:593-600. 2005
    ..The purpose of this study was to evaluate the capacity of [11C]6-OH-BTA-1 and positron emission tomography (PET) to quantify beta-amyloid (Abeta) plaques in the Tg2576 mouse model of Alzheimer's disease (AD)...
  86. ncbi Lisinopril: a review of its use in congestive heart failure
    K Simpson
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 59:1149-67. 2000
    ..5 to 35mg, administered once daily) of lisinopril in the Assessment of Treatment with Lisinopril and Survival (ATLAS) study demonstrated clinically important advantages over low doses (2...
  87. ncbi Simulation and assessment of cerebrovascular damage in deep brain stimulation using a stereotactic atlas of vasculature and structure derived from multiple 3- and 7-tesla scans
    Wieslaw L Nowinski
    Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore
    J Neurosurg 113:1234-41. 2010
    ..Therefore, the authors proposed the use of a detailed 3D stereotactic cerebrovascular atlas to assist in SFN planning and to potentially reduce DBS-induced hemorrhage.
  88. ncbi Applied anatomy of transoral atlantoaxial reduction plate internal fixation
    FuZhi Ai
    Department of Orthopedics, Liuhuaqiao Hospital, Guangzhou, People s Republic of China
    Spine (Phila Pa 1976) 31:128-32. 2006
    ..The anatomic parameters in relation to transoral atlantoaxial reduction plate (TARP) internal fixation were measured...
  89. ncbi Radiographic evaluation of foot osteoarthritis: sensitivity of radiographic variables and relationship to symptoms
    H B Menz
    Musculoskeletal Research Centre, Faculty of Health Sciences, La Trobe University, Bundoora, Victoria 3086, Australia
    Osteoarthritis Cartilage 17:298-303. 2009
    To evaluate a radiographic atlas for grading foot osteoarthritis (OA) in relation to the relative sensitivity of different radiographic and views and features, and to examine the relationship between radiographic OA and foot symptoms.
  90. ncbi [Classification of atlas pedicles and methodological study of pedicle screw fixation]
    Fan He
    Department of Spinal Cord Injury, General Hospital of inan Military Area, Jinan Shandong, 250031, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:905-9. 2008
    To investigate the classification of atlas pedicles and the methods of the pedicle screw fixation.
  91. ncbi An international dermatological image atlas on the WWW: practical use for undergraduate and continuing medical education, patient education and epidemiological research
    G Eysenbach
    Unit for Medical Informatics, Epidemiology and Public Health, University Hospital of Dermatology, Erlangen, Germany
    Stud Health Technol Inform 52:788-92. 1998
    We describe the development of an image database DOIA (Dermatological OnlIne Atlas) and present several spin-off projects using images of the atlas, e.g...
  92. ncbi Determining corneal power using Orbscan II videokeratography for intraocular lens calculation after excimer laser surgery for myopia
    Mujtaba A Qazi
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    J Cataract Refract Surg 33:21-30. 2007
    ..To assess the accuracy of Orbscan II slit-scanning videokeratography for intraocular lens (IOL) calculation in eyes with previous photorefractive surgery for myopia...
  93. ncbi Phylogeography of North African Atlas cedar (Cedrus atlantica, Pinaceae): Combined molecular and fossil data reveal a complex Quaternary history
    Anass Terrab
    Department of Systematic and Evolutionary Botany, Institute of Botany, University of Vienna, Rennweg 14, A 1030 Vienna, Austria
    Am J Bot 95:1262-9. 2008
    ..Here we investigate the range-wide population structure and phylogeography of Atlas cedar (Cedrus atlantica), an emblematic forest tree endemic to Morocco and Algeria...
  94. ncbi The morphometric analysis of the V2 and V3 segments of the vertebral artery: normal values on MDCT
    Demet Kiresi
    Department of Radiology, Selcuk University Meram Faculty of Medicine, Konya, Turkey
    Comput Med Imaging Graph 33:399-407. 2009
    ..provided detailed demonstration of the vertebral artery at the craniocervical junction and its relationships with atlas and axis...
  95. ncbi Statistical analysis of 168 bilateral subthalamic nucleus implantations by means of the probabilistic functional atlas
    Wieslaw L Nowinski
    Biomedical Imaging Laboratory, Institute for Infocomm Research, Singapore 119613, Singapore
    Neurosurgery 57:319-30; discussion 319-30. 2005
    ..of cerebral structures from electrophysiological and neuroimaging data by using the probabilistic functional atlas (PFA)...
  96. ncbi First year of mandatory reporting of healthcare-associated infections, Pennsylvania: an infection control-chart abstractor collaboration
    Kathleen G Julian
    Division of Infectious Diseases, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Infect Control Hosp Epidemiol 27:926-30. 2006
    In 2004, the Commonwealth of Pennsylvania mandated hospitals to report healthcare-associated infections (HAIs). The increased workload led our Infection Control staff to collaborate with Atlas, a group of chart abstractors.
  97. ncbi Microelectrode-guided functional neurosurgery assisted by Electronic Clinical Brain Atlas CD-ROM
    W L Nowinski
    Kent Ridge Digital Labs, Singapore
    Comput Aided Surg 3:115-22. 1998
    The Electronic Clinical Brain Atlas is a CD-ROM containing several classic brain atlases and a real-time yet simple registration function that deforms the atlases to match them with specific patient studies...
  98. ncbi Reduced risk of restenosis in small vessels and reduced risk of myocardial infarction in long lesions with the new thin-strut TAXUS Liberté stent: 1-year results from the TAXUS ATLAS program
    Mark A Turco
    Center for Cardiac and Vascular Research, Washington Adventist Hospital, Takoma Park, Maryland 20912, USA
    JACC Cardiovasc Interv 1:699-709. 2008
    The TAXUS ATLAS Small Vessel (SV) and Long Lesion (LL) multicenter studies compared the performance of the thin-strut (0.0038 inch) TAXUS Liberté 2...
  99. pmc The Medicago truncatula gene expression atlas web server
    Ji He
    Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, OK 73401, USA
    BMC Bioinformatics 10:441. 2009
    ..We developed the Medicago truncatula Gene Expression Atlas (MtGEA) web server for this purpose.
  100. ncbi [Clinical application and personal X-ray film and CT design of screw-plate system by pedicle of atlanto-axis manipulatively]
    Weidou Jia
    Department of Orthopedics, 251st Hospital of PLA, Zhangjiakou Hebei, 075000, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:416-20. 2008
    ..To study project of simplicity and utility for screw-plate system by pedicle of atlanto-axis manipulatively hand by X-ray film and CT to prove the one success rate of putting screws...
  101. pmc Relationship between the morphology of the atlanto-occipital joint and the radiographic results in patients with atlanto-axial subluxation due to rheumatoid arthritis
    Haku Iizuka
    Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, 3 39 22, Showa, Maebashi, Gunma, 371 8511, Japan
    Eur Spine J 17:826-30. 2008
    ..However, there are occasional patients who show no motion between the occipital bone and atlas on a dynamic cervical radiograph in AAS patients...

Research Grants79

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..mental health (the LCNN), will serve as a proof of concept for our long- term goal: to establish a comprehensive atlas of developmental epigenomic events that occur in key neuronal populations purified from specific brain regions and ..
  3. Improving Patient Safety: Context and Nurses'Work Processes for Pressure Ulcers
    Lynn M Soban; Fiscal Year: 2013
    ..We will use Atlas.ti to perform content analysis of these data...
  4. Genomics of RNA Editing: Identification and Regulation
    Jin Billy Li; Fiscal Year: 2013
    ..our recent success at developing experimental and computational frameworks to the generation of a comprehensive atlas of RNA editing sites in humans and mice...
  5. Epigenome Mapping in Cortical Interneurons
    Schahram Akbarian; Fiscal Year: 2013 to 1) provide the research community and public domain for the first time with a comprehensive genome-wide atlas of the histone methylation landscape in selected subpopulations of cortical GABAergic interneurons and other cells ..
    Christine A Curcio; Fiscal Year: 2012
    ..3. Establish an electronic atlas of ARM pathology to inform next-generation tomographic imaging by scanning each tissue slide in its entirety and ..
  7. A Developmental Craniofacial Atlas for the Zebrafish
    Charles B Kimmel; Fiscal Year: 2010
    ..We propose to construct a developmental atlas for the craniofacial skeleton of zebrafish, a widely used model organism for understanding conserved features of ..
  8. Robust BCT for Clinical Use
    DAVID KOPPERDAHL; Fiscal Year: 2010
    ..acquisition parameters on scanning standardization;and use machine learning techniques to develop a "statistical atlas" of the spine for automation of all image processing...
  9. Oncogene cooperation in glioma genesis
    Wei Zhang; Fiscal Year: 2013
    ..Intensive research over the last three decades, especially recent genomics research (The Cancer Genome Atlas on glioblastoma), has revealed a large number of putative oncogenes that are amplified and overexpressed in glioma,..
  10. Nuclear Receptor Networks in Human Disease
    Frances M Sladek; Fiscal Year: 2010, and the NIH-funded Nuclear Receptor Signaling Atlas (NURSA) (
    Jin Moo Lee; Fiscal Year: 2010 automatically transferred to a secure storage array, from which they can be accessed for quantitative analysis, atlas formation, or web navigation as either public or password-protected content...
  12. Gene Expression Patterns in Human Tumors Identified Using Transcript Sequencing
    Charles M Perou; Fiscal Year: 2013
    ..In the pilot phase of The Cancer Genome Atlas (TCGA) project, multiple platforms were used including tools to study gene expression (our role), tumor genomic ..
  13. Molecular mechanisms of GBM radioresistance and strategies for radiosensitization
    Sandeep Burma; Fiscal Year: 2013
    ..The recent mapping of the GBM genome by the Cancer Genome Atlas Network revealed that these tumors have radically altered genomes with many mutations, gene copy number gains and ..
    Elaine R Mardis; Fiscal Year: 2013
    ..project (pilot 3 studies), to the sequencing of 6,000 genes in ovarian cancer samples for The Cancer Genome Atlas (TCGA), and will soon be applied to a set of 500 genes suspected in retinitis pigmentosa, as well as to our NHGRI-..
  15. Understanding and Eliminating Oncogenic EGFR Signaling in Malignant Glioma
    Alain Charest; Fiscal Year: 2013
    ..Together, these features commensurably complement the retrospective studies brought forward by The Cancer Genome Atlas by providing a much-needed animal system capable of efficient analysis of gene function.
  16. Functional characterization of D3 dopamine receptor in Drd3-EGFP transgenic mice
    Eldo V Kuzhikandathil; Fiscal Year: 2010
    ..hypothesis using the novel Drd3-EGFP transgenic mouse model generated by the NINDS Gene Expression Nervous System Atlas (GENSAT) Project...
  17. Atlas - A Handheld High Resolution Wide-field Retinal Imager
    PAUL ANDREW YATES; Fiscal Year: 2013
    ..In this application, RetiVue LLC proposes to develop the Atlas, a low cost (<$5,000 market cost), high resolu- tion, hand-held device capable of wide-field imaging of the ..
  18. An infrastructure for cancer virus discovery from next-generation sequencing data
    Matthew L Meyerson; Fiscal Year: 2010
    ..Large-scale genome projects, including The Cancer Genome Atlas (TCGA) as well as studies of germ-line genetic correlations with cancer, are now moving towards the application of ..
  19. Role of EZH2 in Epithelial Ovarian Cancer
    Rugang Zhang; Fiscal Year: 2013
    ..To prioritize the identified genes for validation, we examined their expression in the Cancer Genome Atlas EOC database and discovered that 3 of the 60 genes are downregulated >2-fold with concurrent EZH2 upregulation ..
  20. Let-7 miRNA control of heart development
    Cathy J Hatcher; Fiscal Year: 2010
    ..We will develop an atlas of let-7 expression and a series of adenoviral and mouse reagents that will be resources for the community's ..
  21. A high-resolution in situ proteomics atlas of salivary gland development
    Melinda Larsen; Fiscal Year: 2010
    ..The end product will include a high- resolution in situ proteomics-based atlas, which categorizes and quantifies active signaling protein expression levels within specific cell types and ..
  22. CNV Atlas of Human Development
    Ronald Wapner; Fiscal Year: 2010
  23. CRCNS:US French Coll:Computational Imaging of the Aging Cerebral Microvasculature
    Bradley P Sutton; Fiscal Year: 2013
    ..will provide quantitative descriptions of regional variations in the cortex, which could form the basis of an atlas of micro-vascular topology...
  24. Variation in the Safety of Back Pain-Related Surgery
    Sohail K Mirza; Fiscal Year: 2010
    ..We also will describe geographic variation in back surgery Overuse across the 344 Dartmouth Atlas United States Hospital Referral Regions (HRR) and 3,300 Hospital Service Areas (HSA)...
  25. The Lymphangioleiomyomatosis (LAM)Genome Atlas
    DAVID J contact KWIATKOWSKI; Fiscal Year: 2010
    ..These studies will provide insight into how this disease develops, and enable novel treatment approaches to prevent lung destruction in women with LAM. ..
  26. Automatic Segmentation of Organs in Computed Tomography for Radiation Therapy Pla
    MARK MCKENZIE RODEN; Fiscal Year: 2011
    ..We will construct a novel feature dictionary, implicitly incorporate atlas-based segmentation methods through the use of image registration techniques, and build a modest "ground truth" ..
  27. Automatic Detection of Critical Dermoscopy Features for Basal Cell Carcinoma
    William V Stoecker; Fiscal Year: 2010
    ..The S&A SkinScan Training System is comprised of 3 parts: Dermoscopy cancer detection software with searchable atlas, DermLite D3 cross-polarized light dermoscope, and Melanoma and Mimics Clinical Tutorial...
  28. Novel algorithms and hardware designs for ultra-fast next-gen sequence analysis
    Onur Mutlu; Fiscal Year: 2013
    ..Our research will broadly impact large-scale genome studies such as the 1000 Genomes Project, the Can- cer Genome Atlas Project, and the ENCODE Project, by not only increasing their ability to reach conclusions very fast but also ..
  29. Transcriptome-wide Polyadenylation Site Use in Male Germ Cell Transcripts
    BECKY SARTINI; Fiscal Year: 2013
    ..several goals of the 2011 NICHHD Scientific Vision Workshop on Reproduction including contributing to a molecular atlas of fundamental male gametogenesis by using current high throughput sequencing and bioinformatics...
  30. A Genetic Screen for HCC Genes
    ..address the mission of the National Cancer Institute's plan to create a comprehensive human cancer genome atlas. While some insight has been gained in the somatic changes that can occur in HCC, it is likely that much remains ..
  31. Chemotherapy Near Death: Modifiable Factors and Outcomes in Ovarian Cancer
    Alexi Wright; Fiscal Year: 2013
    ..The determinants of EOL chemotherapy use are poorly understood. Researchers from the Dartmouth Health Care Atlas have argued that cancer patients'EOL care is determined by medical supply factors, not patient preferences...
    Nicholas D Schiff; Fiscal Year: 2013
    ..He will also supervise the development and analysis of a probabilistic atlas to identify the sites of optimal application of CT/DBS...
  33. Transcriptional Atlas of Human Brain Development
    PAT R LEVITT; Fiscal Year: 2010
    We will create a transcriptional atlas of the developing human brain, including novel transcripts and regional expression patterns that can be followed up subsequently with histochemical mapping for cellular specificity...
  34. Pediatric Percutaneous Cochlear Implantation Clinical Validation &Implementation
    Robert F Labadie; Fiscal Year: 2012
    ..will allow us to perform step (iii) in an automated fashion, as we are currently doing for adults with a single atlas. Because federal guidelines prohibit clinical studies on children entailing greater than minimal risk without the ..
  35. Diet-Induced Plasticity of Proopiomelanocortin Neurons
    AARON JEFFREY MERCER; Fiscal Year: 2012
    ..changes in POMC innervations, and will allow us to reconstruct the central POMC network into a complete atlas. Taken together, deciphering the structure and function of central POMC neurons will lend insight into neural ..
  36. Technology for detection and quantitation of telomeric DNA aberrations in cancer
    Harold C Riethman; Fiscal Year: 2012
    ..totally absent from the high- throughput datasets being acquired from tumor samples as part of the Cancer Genome Atlas, and telomere mutational data gleaned from a few labor-intensive studies of telomere function in cellular and ..
  37. A Gene Expression Brain Atlas of the Zebra Finch.
    Claudio V Mello; Fiscal Year: 2013
    ..To achieve this goal, we propose a single Specific Aim, namely to generate a Gene Expression Brain Atlas of the Zebra Finch...
  38. nGUDMAP ??? Ontology, Database and Website Core
    RICHARD ALAN BALDOCK; Fiscal Year: 2013
    ..The nGUDMAP Core Atlas Assembly Project is an extension of the existing GUDMAP resource, the main objective of which is supporting the ..
  39. Single Cell/RNA-Seq dissection of Human iPS cell development into intestine
    James M Wells; Fiscal Year: 2013 applicant): We propose to combine two rapidly evolving technologies to generate a single cell resolution atlas of the gene expression patterns that drive intestinal development...
  40. The Epigenetic Landscape of Heart Development
    Shinya Yamanaka; Fiscal Year: 2013
    ..Our studies will yield an important and transformative epigenetic atlas of heart development, which will link for the first time transcriptional and epigenetic regulators in a ..
  41. Complete Human Peptide- and MRM-Atlas
    ROBERT L contact MORITZ; Fiscal Year: 2010
  42. Atlases to Report and Correlate Radiotherapy Dose Distributions with Outcomes
    Andrew Jackson; Fiscal Year: 2013
    ..These methods are termed "atlases" of radiotherapy outcomes statistics and dose distribution variable. The atlas method aims to comprehensively display dose distribution, medical cofactors, and outcomes statistics from ..
  43. Predictors of Speech Quality after Tongue Cancer Surgery
    Maureen Stone; Fiscal Year: 2013
    ..Results of the project will include a unique atlas of normal tongue deformation and patient comparisons, a better understanding of the impacts of tongue cancer ..
  44. Novel Biomarkers for Aromatase Inhibitor Therapy
    Matthew J Ellis; Fiscal Year: 2013
    ..Our long term goal is to generate a luminal breast cancer atlas that is annotated for clinical outcomes so that the treatment of ER+ breast cancer can be individually tailored ..
  45. Novel integrative method to detect biomakers of breast cancer resistance
    Sheida Nabavi; Fiscal Year: 2013
    ..We will hone and validate the innovative methods and tools on publically available data such as The Cancer Genome Atlas (TCGA) data...
  46. Characterizing and Targeting CHD4 Deficiency in Endometrial Cancer
    Shiaw Yih Lin; Fiscal Year: 2013
    ..Through analyzing gene sequencing data from The Cancer Genome Atlas, we have found a high rate of mutation of CHD4 in endometrial cancer (15% in EEC and 35% in UPSC)...
  47. Effectiveness of Feeding Tubes Among Person with Advanced Cognitive Impairment
    Joan M Teno; Fiscal Year: 2010
    ..the linkage of four files (Medicare Claims, Minimum Data Set, American Hospital Association data, and Dartmouth Atlas of Health Care) from 1999-2008 and Medicare Part D data from 2006-2008...
  48. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2009
    ..Hence, expression data needs to be communally collected as in situ data and amassed in a visual atlas. As part of our current funding from the NIDDK, we have generated (and will continue to do so) expression profilng ..
  49. A Quantitative Proteomics Platform to Characterize the Nicotine-Dependent Brain
    JOHN ROBERT YATES; Fiscal Year: 2010
    ..termed qPEMM (for quantitative Protein Expression and Modification in Mammals) will be applied to create a brain atlas of proteomic changes that occur in nicotine-dependent rodents...
    Franz Halberg; Fiscal Year: 2012
    ..This work led to the birth of the new field of chronomics and the start of an atlas of chronomes, the major topic to be pursued in the next few years...
  51. Cancer Genome Characterization Center at Johns Hopkins
    Stephen Baylin; Fiscal Year: 2009
    ..describes a detailed plan for a Cancer Genome Characterization Center (CGCC) to act as part of The Cancer Genome Atlas (TCGA) project...
  52. The First Comprehensive Neural Connectivity Map of Mouse
    PARTHA PRATIM MITRA; Fiscal Year: 2010
    ..images from all of the individual injections will be combined by spatially registering them to the Allen Reference Atlas, ultimately generating a unified brainwide neural connectivity map...
  53. Molecular profiling of HIV-associated lymphoma in the US and Malawi
    Satish Gopal; Fiscal Year: 2013
    ..clinical research program in Lilongwe, and inclusion as one of seven Data Analysis Centers for The Cancer Genome Atlas project. The proposed research additionally builds on two ongoing NIH-funded studies for which Dr...
  54. Leukemia Stem Cell Antigen Discovery Using Advanced Genomic and Proteomic Methods
    PAUL MICHAEL ARMISTEAD; Fiscal Year: 2013
    ..Perou is a leader in the field of cancer genomics, and the leader of the UNC contribution to The Cancer Genome Atlas. He has mentored many graduate and post-doctoral students and has developed a comprehensive training and ..
  55. A 3-D Interactive Atlas of the Hand & Wrist Joints
    Kevin N Montgomery; Fiscal Year: 2010
    ..Application of these sophisticated viewing protocols will create an Atlas-At-Large, and will be used to develop interactive hand and wrist teaching models of annotated, rotating volumetric ..
  56. Structural Development of Human Fetal Brain
    Hao Huang; Fiscal Year: 2013
    ..The structural DTI atlas will provide reference standards for diagnostic radiology of premature newborns and a valuable resource to ..
  57. A 3-D Interactive Atlas of the Human Skull
    Kevin N Montgomery; Fiscal Year: 2010
    ..This skull database project, which builds upon and is an extension of the Tooth Atlas project, will be the first phase of a complete, whole body, osteology library...
  58. Novel Genetic Models to Study the Role of DNp63 in Squamous Cell Carcinoma
    Rose Anne Romano; Fiscal Year: 2013
    ..our laboratory as well as others, together with the large-scale sequencing data emerging from the Cancer Genome Atlas Project, strongly suggest that the transcription factor p63, specifically the most prevalent Np63 isoforms, ..
  59. Predictive Modeling for Treatment of Upper Airway Obstruction in Young Children
    Carlton J Zdanski; Fiscal Year: 2013
    ..stenosis;data and modeling of normal airways will be obtained to help develop a Pediatric Airway Anatomical Atlas describing the aging airway;an integrated Virtual Pediatric Airway Workbench will also be developed (1b) validate ..
  60. CSHL Molecular Target Discovery and Development Center
    Scott Powers; Fiscal Year: 2010
    ..Target Discovery and Development Center (MTDDC) that will act as downstream component of The Cancer Genome Atlas (TCGA) project...
  61. Transcriptional Atlas of Human Brain Development
    Nenad Sestan; Fiscal Year: 2010 conduct a spatiotemporally comprehensive survey of the human brain transcriptome and create a unique multimodal atlas encompassing all pre- and postnatal developmental stages, including adolescence and adulthood...
  62. Autoimmunity and age-related changes in thymic induction of self-tolerance.
    Howard T Petrie; Fiscal Year: 2013 include multiple sortable quantitative parameters, and direct (hypertext) links to relevant informatic (body atlas) and genetic (mouse mutant) resources, as well as to predicted MHC class II-binding peptides from these TRA...
    William Duax; Fiscal Year: 2001
    ..most potent progestins, estrogens and corticoids, and produced 164 manuscripts, 34 chapters and two volumes of the Atlas of Steroid Structures in which the structural determinations were reported and their significance discussed...
  64. Identifying Low-Risk Patients with Pulmonary Embolism
    Drahomir Aujesky; Fiscal Year: 2005
    ..This is a retrospective cohort study using 3 large and reliable databases, the PHC4 database, the MediQual Atlas database, and the National Death Index (NDI)...
    JEREMY SCHMAHMANN; Fiscal Year: 1999
    This application to the National Library of Medicine is to provide short term assistance for the preparation of an atlas of the human cerebellum in printed book form and on CD-ROM...
  66. A 3-D Interactive Atlas of the Maxilla, Mandible & TMJ
    William Brown; Fiscal Year: 2006
    ..The third Aim is to develop a comprehensive Atlas of the TMJ...
  67. A 3-D Interactive Atlas of Thumb Carpometacarpal Joint
    William Brown; Fiscal Year: 2004
    ..This opens the door for developing similar high-resolution models in other anatomic sites and organ systems. ..
  68. Isolating Mechanisms Underlying Hospital Variation in End-of-Life ICU Use
    Amber E Barnato; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The Dartmouth Atlas of Health Care has demonstrated considerable variability among hospitals in intensive care unit (ICU) use at the end of life...
    H K Huang; Fiscal Year: 2006
    ..The most common clinical method for bone age assessment is atlas matching by a left-hand wrist radiograph against a small reference set of atlas patterns of normal standards ..
  70. Identify neuroendocrine genes that are vulnerable to chronic psychological stress
    Hong Wei Dong; Fiscal Year: 2010
    ..the candidate gene pool generated in Specific Aim 1 and (2) the online gene expression database-the Allen Brain Atlas (ABA)...
    Barbara Wold; Fiscal Year: 1999
    ..The rationale for this is that such an atlas of development will prove to be useful in analyzing the impact of mutations on these structures...
    Edward H Herskovits; Fiscal Year: 2010 accommodate acute-stroke data;implemented our Bayesian approach to morphometry;constructed a probabilistic atlas of acute-stroke lesions;and re-implemented BRAID using open-source components, improving the user interface and ..
  73. Spatial Information Management Resources for Human Brain
    DOUGLAS BOWDEN; Fiscal Year: 2007
    ..incorporated into a system of neuroanatomical definitions that illustrates structural concepts by reference to an atlas of the nonhuman primate brain...
  74. Digital probabilistic MRI atlas of primate brain with toolkits for surgery guidan
    Hao Huang; Fiscal Year: 2010
    The goal of the project is to develop a fully digital package including three dimensional (3D) probabilistic atlas, brain and head coordinate systems and toolkits for invasive procedure guidance and data analysis...
  75. A 3D DVD Atlas of Human Development
    MICHAEL HULTNER; Fiscal Year: 2002
    ..This proposal describes the development of a 3D atlas of human development based on volume-rendered computer graphic models of human embryos reconstructed from primary ..
  76. A 3-D Interactive Atlas of the Human Mandible and TMJ
    William Brown; Fiscal Year: 2003
    ..The result will be improved clinical outcomes and a reduction in the potential for untoward results. ..
    William Brown; Fiscal Year: 2001
    ..We expect that it will currently be a required purchase by the 4200 freshman dental students in the 55 US dental schools. We also expect a large international market. ..
    Alfred Rimm; Fiscal Year: 1991
    ..The U.S. Bureau of Census files and the Area Resource File with county information will also be used. The atlas will consist of a total of 142 national maps of cancer incidence for selected sites...
  79. Augmentation of Accuracy for Image-guided Neurosurgery
    Oskar Skrinjar; Fiscal Year: 2005
    ..In the standard procedure, these boundaries are obtained from a brain atlas. However, the accuracy of the 3rocedure is adversely affected by: the shape and size difference in anatomy of the ..