spine

Summary

Summary: The spinal or vertebral column.

Top Publications

  1. ncbi Three-dimensional movements of the whole lumbar spine and lumbosacral joint
    I Yamamoto
    Department of Orthopaedics, Hokkaido University School of Medicine, Sapporo, Japan
    Spine (Phila Pa 1976) 14:1256-60. 1989
  2. ncbi Cervical spine motion: a fluoroscopic comparison during intubation with lighted stylet, GlideScope, and Macintosh laryngoscope
    Timothy P Turkstra
    Department of Anesthesia and Perioperative Medicine, University of Western Ontario, 339 Windermere Road, London, Ontario, Canada N6A 5A5 corrected
    Anesth Analg 101:910-5, table of contents. 2005
  3. ncbi Embryology of the spine and associated congenital abnormalities
    Kevin M Kaplan
    New York University, Hospital for Joint Diseases, Department of Orthopaedic Surgery, 14th Floor, 301 East 17th Street, New York, NY 10003, USA
    Spine J 5:564-76. 2005
  4. ncbi Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation
    Charles D Kopec
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 26:2000-9. 2006
  5. ncbi Correlates of the peak height velocity in girls with idiopathic scoliosis
    James O Sanders
    Shriners Hospitals for Children, Erie, PA 16505, USA
    Spine (Phila Pa 1976) 31:2289-95. 2006
  6. ncbi Fetal spine ossification: the gender and individual differences illustrated by ultrasonography
    M Vignolo
    Department of Pediatrics, First Pediatric Clinic, University of Genoa, G Gaslini Institute, Genoa, Italy
    Ultrasound Med Biol 31:733-8. 2005
  7. ncbi Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial
    Roy A Patchell
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Lancet 366:643-8. 2005
  8. ncbi New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures
    S R Garfin
    University of California, San Diego, California, USA
    Spine (Phila Pa 1976) 26:1511-5. 2001
  9. ncbi Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine
    A Okawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Nat Genet 19:271-3. 1998
  10. doi Spine computed tomography doses and cancer induction
    Paula J Richards
    X Ray Department, University Hospital of North Staffordshire NHS Trust, Staffordshire, United Kingdom
    Spine (Phila Pa 1976) 35:430-3. 2010

Research Grants

  1. Tibor T Glant; Fiscal Year: 2016
  2. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
  3. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
  4. Epigenetics of Sex Differences in Brain and Behavior
    BRIDGET NUGENT; Fiscal Year: 2012
  5. MARK L DELL'ACQUA; Fiscal Year: 2016
  6. Subhash C Pandey; Fiscal Year: 2014
  7. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
  8. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
  9. Subhash C Pandey; Fiscal Year: 2016
  10. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012

Detail Information

Publications484 found, 100 shown here

  1. ncbi Three-dimensional movements of the whole lumbar spine and lumbosacral joint
    I Yamamoto
    Department of Orthopaedics, Hokkaido University School of Medicine, Sapporo, Japan
    Spine (Phila Pa 1976) 14:1256-60. 1989
    Knowledge of the normal movements of whole lumbar spine and lumbosacral joint is important for evaluating clinical pathologic conditions that may potentially produce unstable situations in these regions...
  2. ncbi Cervical spine motion: a fluoroscopic comparison during intubation with lighted stylet, GlideScope, and Macintosh laryngoscope
    Timothy P Turkstra
    Department of Anesthesia and Perioperative Medicine, University of Western Ontario, 339 Windermere Road, London, Ontario, Canada N6A 5A5 corrected
    Anesth Analg 101:910-5, table of contents. 2005
    The question of which is the optimum technique to intubate the trachea in a patient who may have a cervical(C)-spine injury remains unresolved...
  3. ncbi Embryology of the spine and associated congenital abnormalities
    Kevin M Kaplan
    New York University, Hospital for Joint Diseases, Department of Orthopaedic Surgery, 14th Floor, 301 East 17th Street, New York, NY 10003, USA
    Spine J 5:564-76. 2005
    The spine is a complex and vital structure...
  4. ncbi Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation
    Charles D Kopec
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 26:2000-9. 2006
    ..green fluorescent protein to tag recombinant glutamate receptors and monitor their dynamics onto dendritic spine surfaces...
  5. ncbi Correlates of the peak height velocity in girls with idiopathic scoliosis
    James O Sanders
    Shriners Hospitals for Children, Erie, PA 16505, USA
    Spine (Phila Pa 1976) 31:2289-95. 2006
    ..Prospective longitudinal...
  6. ncbi Fetal spine ossification: the gender and individual differences illustrated by ultrasonography
    M Vignolo
    Department of Pediatrics, First Pediatric Clinic, University of Genoa, G Gaslini Institute, Genoa, Italy
    Ultrasound Med Biol 31:733-8. 2005
    ..Sonographic evaluation of the fetal spine depends on visualization of the ossification centers, but the sequence of development of ossification centers in ..
  7. ncbi Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial
    Roy A Patchell
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Lancet 366:643-8. 2005
    ..The standard treatment for spinal cord compression caused by metastatic cancer is corticosteroids and radiotherapy. The role of surgery has not been established. We assessed the efficacy of direct decompressive surgery...
  8. ncbi New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures
    S R Garfin
    University of California, San Diego, California, USA
    Spine (Phila Pa 1976) 26:1511-5. 2001
    ..Literature review...
  9. ncbi Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine
    A Okawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Nat Genet 19:271-3. 1998
    Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common form of human myelopathy caused by a compression of the spinal cord by ectopic ossification of spinal ligaments...
  10. doi Spine computed tomography doses and cancer induction
    Paula J Richards
    X Ray Department, University Hospital of North Staffordshire NHS Trust, Staffordshire, United Kingdom
    Spine (Phila Pa 1976) 35:430-3. 2010
    ..Computer modeling using patient computed tomography (CT) exposure data...
  11. doi Electromyographic monitoring and its anatomical implications in minimally invasive spine surgery
    Juan S Uribe
    Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA
    Spine (Phila Pa 1976) 35:S368-74. 2010
    ..Literature review...
  12. doi A comprehensive review of the safety profile of bone morphogenetic protein in spine surgery
    David Benglis
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    Neurosurgery 62:ONS423-31; discussion ONS431. 2008
    ..understanding of the development and potential clinical applications of bone morphogenetic protein (BMP) in spine surgery...
  13. ncbi Endotracheal intubation in patients with cervical spine immobilization: a comparison of macintosh and airtraq laryngoscopes
    Chrisen H Maharaj
    Department of Anaesthesia, University College Hospital, Galway, Ireland
    Anesthesiology 107:53-9. 2007
    ..The authors compared ease of intubation with the Airtraq and Macintosh laryngoscopes in patients with cervical spine immobilization in a randomized, controlled clinical trial.
  14. doi The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis
    J Sieper
    Rheumatology, Medizinische Klinik I, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Ann Rheum Dis 68:ii1-44. 2009
    ..assessments of spondyloarthritis, covering classification criteria, MRI and x rays for sacroiliac joints and the spine, a complete set of all measurements relevant for clinical trials and international recommendations for the ..
  15. doi The modic vertebral endplate and marrow changes: pathologic significance and relation to low back pain and segmental instability of the lumbar spine
    R Rahme
    Department of Neurosurgery, Saint Joseph University and Hôtel Dieu de France, Beirut, Lebanon
    AJNR Am J Neuroradiol 29:838-42. 2008
    ..These changes are closely related to the normal degenerative process affecting the lumbar spine, and their prevalence increases with age...
  16. ncbi Primary solitary Echinococcosis in cervical spine. Postsurgical successful outcome after long-term albendazole treatment
    R García-Vicuña
    Rheumatology Unit, Hospital de la Princesa, Madrid, Spain
    Spine (Phila Pa 1976) 25:520-3. 2000
    ..A case report of a young man with isolated cervical hydatidosis treated postoperatively with sustained cyclical albendazole therapy for 9 years of follow-up...
  17. pmc Sagittal spinopelvic balance in normal children and adolescents
    Jean Marc Mac-Thiong
    Division of Orthopaedics, Hopital Sainte Justine, Montreal, QC, Canada
    Eur Spine J 16:227-34. 2007
    ..Sacral orientation (SS) is correlated with the shape (LL) and orientation (LT) of the lumbar spine. Adjacent anatomical regions of the spine and pelvis are interdependent, and their relationships result in a ..
  18. pmc Progression of radiographic damage in patients with ankylosing spondylitis: defining the central role of syndesmophytes
    X Baraliakos
    Rheumazentrum Ruhrgebiet, Landgrafenstr 15, 44652 Herne, Germany
    Ann Rheum Dis 66:910-5. 2007
    ..These can be quantified by the modified Stokes Anklylosing Spondylitis Spinal Score (mSASSS). It is unknown which radiographic feature is most relevant for the assessment of change and the prediction of future damage in AS...
  19. ncbi Vertebral body shape variation in the thoracic and lumbar spine: characterization of its asymmetry and wedging
    Youssef Masharawi
    Spinal Research Laboratory, Department of Physical Therapy, School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Clin Anat 21:46-54. 2008
    ..to characterize the vertebral body (VB) shape, focusing on vertebral wedging, along the thoracic and lumbar spine, and to look for shape variations with relation to gender, age, and ethnicity...
  20. pmc Disruption of PDGFRalpha-initiated PI3K activation and migration of somite derivatives leads to spina bifida
    Elizabeth A Pickett
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Development 135:589-98. 2008
    ....
  21. doi Cdx2 regulation of posterior development through non-Hox targets
    Joanne G A Savory
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    Development 136:4099-110. 2009
    ..We propose a model wherein Cdx2 functions as an integrator of caudalizing information by coordinating axial elongation and somite patterning through Hox-independent and -dependent pathways, respectively...
  22. doi Adult scoliosis surgery outcomes: a systematic review
    Sanjay Yadla
    Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Neurosurg Focus 28:E3. 2010
    ..The purpose of the current study was to systematically review the present spine deformity literature and assess the available data on clinical and radiographic outcome measurements.
  23. doi Recurrent aberrations identified by array-CGH in patients with Mayer-Rokitansky-Küster-Hauser syndrome
    Susanne Ledig
    Institut fur Humangenetik, Westfalische Wilhelms Universitat, Munster, Germany
    Fertil Steril 95:1589-94. 2011
    ..To identify genetic causes of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome...
  24. pmc Effects of etanercept versus sulfasalazine in early axial spondyloarthritis on active inflammatory lesions as detected by whole-body MRI (ESTHER): a 48-week randomised controlled trial
    I H Song
    Campus Benjamin Franklin, Med Clinic I, Rheumatology, Hindenburgdamm 30, 12200 Berlin, Germany
    Ann Rheum Dis 70:590-6. 2011
    ..To evaluate the potential of etanercept versus sulfasalazine to reduce active inflammatory lesions on whole-body MRI in active axial spondyloarthritis with a symptom duration of less than 5 years...
  25. pmc Identification of vertebra-like elements and their possible differentiation from sclerotomes in the hagfish
    Kinya G Ota
    Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, Kobe, Japan
    Nat Commun 2:373. 2011
    ..We conclude that the vertebra-like elements in the hagfish are homologous to gnathostome vertebrae, implying that this animal underwent secondary reduction of vertebrae in most of the trunk...
  26. pmc Square-cut: a segmentation algorithm on the basis of a rectangle shape
    Jan Egger
    Department of Radiology, Surgical Planning Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e31064. 2012
    ..were manually extracted by two clinical experts (neurological surgeons) with several years of experience in spine surgery and afterwards compared with the automatic segmentation results of the proposed scheme yielding an average ..
  27. doi A mechanism for gene-environment interaction in the etiology of congenital scoliosis
    Duncan B Sparrow
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia
    Cell 149:295-306. 2012
    Congenital scoliosis, a lateral curvature of the spine caused by vertebral defects, occurs in approximately 1 in 1,000 live births...
  28. ncbi Visualizing non-Gaussian diffusion: clinical application of q-space imaging and diffusional kurtosis imaging of the brain and spine
    Masaaki Hori
    Department of Radiology, School of Medicine, Juntendo University, Tokyo, Japan
    Magn Reson Med Sci 11:221-33. 2012
    ..and fractional anisotropy, recognized indices for evaluating disease and normal development in the brain and spine. In some clinical situations, sensitivity for detecting pathological conditions is higher using QSI and DKI than ..
  29. pmc VACTERL/VATER Association
    Benjamin D Solomon
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Building 35 Room 1B 207, Bethesda, MD 20892, USA
    Orphanet J Rare Dis 6:56. 2011
    ..Importantly, patients with VACTERL association do not tend to have neurocognitive impairment...
  30. ncbi Medical complications of surgical treatment of adult spinal deformity and how to avoid them
    Eli M Baron
    Institute for Spinal Disorders, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Spine (Phila Pa 1976) 31:S106-18. 2006
    ..Review article of medical complications related to adult spinal deformity surgery...
  31. ncbi Inefficient muscular stabilization of the lumbar spine associated with low back pain. A motor control evaluation of transversus abdominis
    P W Hodges
    Department of Physiotherapy, University of Queensland, Australia
    Spine (Phila Pa 1976) 21:2640-50. 1996
    ..using an experimental model identifying the coordination of trunk muscles in response to a disturbances to the spine produced by arm movement...
  32. pmc Sagittal balance of the pelvis-spine complex and lumbar degenerative diseases. A comparative study about 85 cases
    Cédric Barrey
    Department of Neurosurgery, Hôpital Neurochirurgical P Wertheimer, 59 Boulevard Pinel, 69394 Lyon, France
    Eur Spine J 16:1459-67. 2007
    ..Spino-pelvic alignment was analysed pre-operatively on full spine radiographs...
  33. doi Mid-term to long-term clinical and functional outcomes of minimally invasive correction and fusion for adults with scoliosis
    Neel Anand
    Departments of Surgery, Cedars Sinai Spine Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Neurosurg Focus 28:E6. 2010
    ..The goal of this study was to assess the operative outcomes of adult patients with scoliosis who were treated surgically with minimally invasive correction and fusion...
  34. doi Visualization of the network of primo vessels and primo nodes above the pia mater of the brain and spine of rats by using Alcian blue
    Ho Sung Lee
    Pharmacopuncture Medical Research Center, Korean Pharmacopuncture Institute, Seoul, South Korea
    J Acupunct Meridian Stud 5:218-25. 2012
    ..we were able to visualize the network of the nerve primo vascular system above the pia mater of the brain and spine of rats...
  35. doi Atlas-based segmentation of degenerated lumbar intervertebral discs from MR images of the spine
    Sofia K Michopoulou
    Department of Medical Physics and Bioengineering, University College London, London WC1E 6BT, U K
    IEEE Trans Biomed Eng 56:2225-31. 2009
    ..an age-associated condition related to chronic back pain, while its consequences are responsible for over 90 % of spine surgical procedures. In clinical practice, MRI is the modality of reference for diagnosing disc degeneration...
  36. pmc The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons
    Jeong Yoon Kim
    Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, Daejeon 305 764, Korea
    J Biol Chem 286:37615-24. 2011
    ..Although several guanine nucleotide exchange factors (GEFs) have been implicated in spine development and plasticity in hippocampal neurons, it is not known how many different Rho GEFs contribute to spine ..
  37. pmc Adalimumab effectiveness for the treatment of ankylosing spondylitis is maintained for up to 2 years: long-term results from the ATLAS trial
    D van der Heijde
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Ann Rheum Dis 68:922-9. 2009
    ....
  38. pmc Single-stage closing-opening wedge osteotomy of spine to correct severe post-tubercular kyphotic deformities of the spine: a 3-year follow-up of 17 patients
    S Rajasekaran
    Department of Orthopaedics and Spine Surgery, Ganga Hospital, 313, Mettupalayam Road, Coimbatore, 641011 Tamil Nadu, India
    Eur Spine J 19:583-92. 2010
    ..The procedure has the advantage of being a posterior only, single-stage correction, which allows for significant correction with minimal complications...
  39. doi Sitting postures and trunk muscle activity in adolescents with and without nonspecific chronic low back pain: an analysis based on subclassification
    Roslyn G Astfalck
    Curtin University of Technology, Perth, Western Australia, Australia
    Spine (Phila Pa 1976) 35:1387-95. 2010
    ..A preliminary cross-sectional comparative study of adolescents with nonspecific chronic low back pain (NSCLBP) and healthy controls...
  40. doi Cross-sectional analysis of the association between fragility fractures and bone microarchitecture in older men: the STRAMBO study
    Pawel Szulc
    INSERM UMR 1033, Universite de Lyon, Hospices Civils de Lyon, Lyon, France
    J Bone Miner Res 26:1358-67. 2011
    ..Thus bone microarchitecture may be a determinant of bone fragility in men, which should be investigated in prospective studies...
  41. pmc Relation of vertebral deformities to bone density, structure, and strength
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 25:1922-30. 2010
    ..aBMD was measured by dual-energy X-ray absorptiometry (DXA), lumbar spine volumetric bone mineral density (vBMD) and geometry by quantitative computed tomography (QCT), bone microstructure ..
  42. ncbi Introduction: the immature spine
    Peter F Armstrong
    J Bone Joint Surg Am 89:1-2. 2007
  43. ncbi Homeosis and intestinal tumours in Cdx2 mutant mice
    K Chawengsaksophak
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Nature 386:84-7. 1997
    ..In contrast to the surrounding intestinal epithelium, the neoplastic cells do not express Cdx2 from the remaining allele. These results suggest that Cdx2 mutation is the primary event in the genesis of some intestinal tumours...
  44. ncbi Quantification of skeletal kinetic indices in Paget's disease using dynamic 18F-fluoride positron emission tomography
    G J R Cook
    Department of Nuclear Medicine, Royal Marsden Hospital, Sutton, Surrey, United Kingdom
    J Bone Miner Res 17:854-9. 2002
    ....
  45. ncbi Cost-effectiveness of lumbar spine radiography in primary care patients with low back pain
    Paul Miller
    School of Economics and Trent Institute for Health Services Research, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom
    Spine (Phila Pa 1976) 27:2291-7. 2002
    ..Fifty-two practices in the East Midlands, United Kingdom, were included...
  46. ncbi An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty
    Frank M Phillips
    University of Chicago Spine Center, Chicago, Illinois 60640, USA
    Spine (Phila Pa 1976) 27:2173-8; discussion 2178-9. 2002
    ..A prospective in vivo study was conducted during the performance of kyphoplasty for the treatment of osteoporotic vertebral compression fractures, comparing extravertebral contrast extravasation with kyphoplasty and vertebroplasty...
  47. ncbi Trunk muscle recruitment patterns in patients with low back pain enhance the stability of the lumbar spine
    Jaap H van Dieen
    Institute for Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands
    Spine (Phila Pa 1976) 28:834-41. 2003
    ..A comparative study of trunk muscle recruitment patterns in healthy control subjects and patients with chronic low back pain was conducted...
  48. ncbi Intravertebral clefts in osteoporotic vertebral compression fractures
    Fergus McKiernan
    Center for Bone Diseases, Marshfield Clinic, Marshfield, Wisconsin 54449, USA
    Arthritis Rheum 48:1414-9. 2003
    ..To describe the characteristics, radiographic appearance, and significance of intravertebral clefts in vertebral compression fractures (VCFs) of patients with osteoporosis presenting for vertebroplasty...
  49. pmc The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments
    Markus Bussen
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Genes Dev 18:1209-21. 2004
    ..In summary, Tbx18 appears to act downstream of Mesp2 and Delta/Notch signaling to maintain the separation of anterior and posterior somite compartments...
  50. ncbi Hemivertebra: prenatal diagnosis, incidence and characteristics
    Israel Goldstein
    Department of Obstetrics and Gynecology, Rambam Medical Center, and Rappaport Faculty of Medicine, Technion, Israel
    Fetal Diagn Ther 20:121-6. 2005
    ..rare congenital spinal anomaly where only one side of the vertebral body develops, resulting in deformation of the spine, such as scoliosis, lordosis, or kyphosis...
  51. ncbi Spine biomechanics
    Michael A Adams
    Department of Anatomy, University of Bristol, UK
    J Biomech 38:1972-83. 2005
    Current trends in spine research are reviewed in order to suggest future opportunities for biomechanics. Recent studies show that psychosocial factors influence back pain behaviour but are not important causes of pain itself...
  52. doi Improvements in vertebral body strength under teriparatide treatment assessed in vivo by finite element analysis: results from the EUROFORS study
    Christian Graeff
    Medical Physics, Department of Diagnostic Radiology, Michaelisstrasse 9, D 24105 Kiel, Germany
    J Bone Miner Res 24:1672-80. 2009
    ..BV/TV), as well as DXA-based areal BMD of the lumbar spine. Local damage of the bone tissue was also modeled...
  53. doi Replication study of the association between adolescent idiopathic scoliosis and two estrogen receptor genes
    Yohei Takahashi
    Center for Genomic Medicine, RIKEN, Minato ku, Tokyo, Japan
    J Orthop Res 29:834-7. 2011
    ..Considering the statistical power of the present study and the limitations of the previous reports, we conclude that the associations of rs9340799 and rs1256120 with AIS predisposition and curve severity are negative...
  54. ncbi Normalized cuts in 3-D for spinal MRI segmentation
    Julio Carballido-Gamio
    Joint Graduate Group in Bioengineering, University of California, San Francisco, 94143 1290, USA
    IEEE Trans Med Imaging 23:36-44. 2004
    ..approximation method to segment vertebral bodies from sagittal T1-weighted magnetic resonance images of the spine. The magnetic resonance images were preprocessed by the anisotropic diffusion algorithm, and three-dimensional ..
  55. ncbi Incidental durotomy in spine surgery
    F P Cammisa
    SpineCare Institute, Hospital for Special Surgery, New York, New York 10021, USA
    Spine (Phila Pa 1976) 25:2663-7. 2000
    ..Retrospective review of a large series of patients who underwent spinal surgery at a single institution during a 10-year period...
  56. ncbi A minimally invasive technique for decompression of the lumbar spine
    Bernard H Guiot
    Institute for Spine Care, Chicago Institute of Neurosurgery and Neuroresearch, Chicago, Illinois, USA
    Spine (Phila Pa 1976) 27:432-8. 2002
    ..The technical feasibility of percutaneous microendoscopic bilateral decompression of lumbar stenosis via a unilateral approach was evaluated in a human cadaver model...
  57. pmc Genetic linkage localizes an adolescent idiopathic scoliosis and pectus excavatum gene to chromosome 18 q
    Christina A Gurnett
    Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Spine (Phila Pa 1976) 34:E94-100. 2009
    ..A single large family, in which adolescent idiopathic scoliosis (AIS) and pectus excavatum (PE) segregate as an autosomal dominant condition, was evaluated. Genome-wide linkage analysis and candidate gene sequencing were performed...
  58. pmc Bone substitutes in vertebroplasty
    P F Heini
    Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Switzerland
    Eur Spine J 10:S205-13. 2001
    ..Animal studies confirm their biocompatibility and osteoconductivity. However, handling problems and the limited radiopacity of these cements currently preclude their clinical use...
  59. doi Spinal mechanical load as a risk factor for low back pain: a systematic review of prospective cohort studies
    Eric W P Bakker
    Department of General Practice, Erasmus University, Rotterdam, The Netherlands
    Spine (Phila Pa 1976) 34:E281-93. 2009
    ..Systematic review...
  60. ncbi Anterior fresh frozen structural allografts in the thoracic and lumbar spine. Do they work if combined with posterior fusion and instrumentation in adult patients with kyphosis or anterior column defects?
    K H Bridwell
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Spine (Phila Pa 1976) 20:1410-8. 1995
    ..This was a prospective study of 24 adult patients with kyphosis or anterior column spinal defects treated with anterior fresh frozen allograft for anterior column defects and posterior instrumentation and autogenous grafting...
  61. pmc Recognizing and reporting osteoporotic vertebral fractures
    Mikayel Grigoryan
    Osteoporosis and Arthritis Research Group, Department of Radiology, University of California San Francisco, 350 Parnassus Avenue, 94117, San Francisco, CA, USA
    Eur Spine J 12:S104-12. 2003
    ..Traditionally, conventional lateral radiographs of the thoracolumbar spine have been visually evaluated by radiologists or clinicians to identify vertebral fractures...
  62. pmc A hypothesis of chronic back pain: ligament subfailure injuries lead to muscle control dysfunction
    Manohar M Panjabi
    Biomechanics Research Laboratory, Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06520 8071, USA
    Eur Spine J 15:668-76. 2006
    ..The hypothesis may help in a better understanding of chronic low back and neck pain patients, and in improved clinical management...
  63. doi The early disease stage in axial spondylarthritis: results from the German Spondyloarthritis Inception Cohort
    Martin Rudwaleit
    Charité Medical University Hospital, Campus Benjamin Franklin, and German Rheumatism Research Centre, Berlin, Germany
    Arthritis Rheum 60:717-27. 2009
    ..Moreover, we sought to identify determinants of the development of radiographic sacroiliitis...
  64. ncbi Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development
    T L Greco
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, 48109 0618 USA
    Genes Dev 10:313-24. 1996
    ..Interestingly, increasing levels of Wnt-3a activity appear to be necessary for the formation of more posterior derivatives of the paraxial mesoderm...
  65. ncbi Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial
    S R Cummings
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    JAMA 280:2077-82. 1998
    ..Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied for women without vertebral fractures...
  66. ncbi Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis
    M P Bulman
    Molecular Genetics, School of Postgraduate Medicine and Health Sciences, Barrack Road, Exeter, UK
    Nat Genet 24:438-41. 2000
    ..These represent the first mutations in a human Delta homologue, thus highlighting the critical role of the Notch signalling pathway and its components in patterning the mammalian axial..
  67. ncbi Biomechanical evaluation of vertebroplasty and kyphoplasty with polymethyl methacrylate or calcium phosphate cement under cyclic loading
    Hans Joachim Wilke
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Ulm, Germany
    Spine (Phila Pa 1976) 31:2934-41. 2006
    ..We developed a new method to simulating in vivo dynamic loading as closely as possible, which allows comparison of kyphoplasty and vertebroplasty, as well as augmentation materials...
  68. pmc Low bone mineral status in adolescent idiopathic scoliosis
    Xin Feng Li
    Department of Orthopaedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Eur Spine J 17:1431-40. 2008
    ....
  69. doi Instrumentation of the osteoporotic spine: biomechanical and clinical considerations
    Karthikeyan E Ponnusamy
    School of Medicine, Stanford University, Palo Alto, CA 94305, USA
    Spine J 11:54-63. 2011
    ..Such patients are more prone to develop painful and debilitating spinal deformities but are difficult to treat. Currently, no definitive treatment algorithm has been established...
  70. doi Classification of sagittal thoraco-lumbo-pelvic alignment of the adolescent spine in standing and its relationship to low back pain
    Anne Smith
    School of Physiotherapy, Curtin University of Technology, Perth, Australia
    Spine (Phila Pa 1976) 33:2101-7. 2008
    ..A prospective study of the sagittal standing posture of 766 adolescents...
  71. ncbi Segmental analysis of the sagittal plane alignment of the normal thoracic and lumbar spines and thoracolumbar junction
    M Bernhardt
    Department of Surgery, University of Kansas School of Medicine, Wichita
    Spine (Phila Pa 1976) 14:717-21. 1989
    ..This retrospective study was undertaken to increase the understanding of the normal alignment of the spine in the sagittal plane, with a special emphasis on the thoracolumbar junction...
  72. doi Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study
    Sherif Elwatidy
    Division of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Spine (Phila Pa 1976) 33:2577-80. 2008
    ..This is a double blind randomized placebo controlled study, after obtaining approval of ethics committee in the hospital and informed written consent, 64 patients were randomized equally into 2 groups (tranexamic acid (TA) and placebo)...
  73. ncbi Comparison of CT scan muscle measurements and isokinetic trunk strength in postoperative patients
    T G Mayer
    Division of Orthopedic Surgery, University of Texas Southwestern Medical Center, Dallas
    Spine (Phila Pa 1976) 14:33-6. 1989
    ..However, no significant difference was found in strength measures between: males with high versus low pain level and working versus nonworking males at the time of evaluation...
  74. ncbi Anatomy of the sheep spine and its comparison to the human spine
    H J Wilke
    Department Unfallchirurgische Forschung und Biomechanik, Universitat Ulm, Germany
    Anat Rec 247:542-55. 1997
    The sheep spine is often used as a model for the human spine, although the degree to which these spines are anatomically comparable has yet to be categorically established...
  75. ncbi Primary bone tumors of the spine. Terminology and surgical staging
    S Boriani
    Department of Orthopaedics and Traumatology, Ospedale Maggiore, Bologna, Italy
    Spine (Phila Pa 1976) 22:1036-44. 1997
    ..The principles of the Enneking system for classifying stages of tumors are emphasized and applied to the spine using a practical approach for surgical staging.
  76. ncbi Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosis
    Masatoshi Inoue
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 27:2357-62. 2002
    ..Analysis of the estrogen receptor gene of girls with idiopathic scoliosis...
  77. ncbi Effect of once-weekly oral alendronate on bone loss in men receiving androgen deprivation therapy for prostate cancer: a randomized trial
    Susan L Greenspan
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Ann Intern Med 146:416-24. 2007
    ..Androgen deprivation therapy (ADT) in men with prostate cancer is associated with bone loss and fractures...
  78. doi Ultrasound imaging of the lumbar spine in the transverse plane: the correlation between estimated and actual depth to the epidural space in obese parturients
    Mrinalini Balki
    Department of Anesthesia and Pain Management, Mount Sinai Hospital, 600 University Avenue, Room 781, Toronto, Ontario, Canada M5G 1X5
    Anesth Analg 108:1876-81. 2009
    ..In this study, we assessed prepuncture lumbar ultrasound scanning as a tool for estimating the depth to the epidural space and determining the optimal insertion point in obese parturients...
  79. pmc Spine: posture, mobility and pain. A longitudinal study from childhood to adolescence
    T Widhe
    Department of Orthopaedics, Huddinge University Hospital, 141 86 Huddinge, Sweden
    Eur Spine J 10:118-23. 2001
    ..The total sagittal mobility of the spine decreased significantly during the 10-year study period: in the thoracic spine by as much as 27 degrees and in the ..
  80. pmc Differential gene expression of bgp and mgp in trabecular and compact bone of Atlantic salmon (Salmo salar L.) vertebrae
    Christel Krossøy
    National Institute of Nutrition and Seafood Research, Bergen, Norway
    J Anat 215:663-72. 2009
    ..Further, the study confirms the presence of mRNA from the vitamin K-dependent proteins BGP and MGP in the vertebrae, fin and gills of Atlantic salmon...
  81. pmc Anatomy of large animal spines and its comparison to the human spine: a systematic review
    Sun Ren Sheng
    Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical College, 109 Xueyuanxi Road, 325027 Wenzhou, China
    Eur Spine J 19:46-56. 2010
    ..However, the extent to which animal models resemble the human spine has not been well known...
  82. doi Complications and radiographic correction in adult scoliosis following combined transpsoas extreme lateral interbody fusion and posterior pedicle screw instrumentation
    Matthew J Tormenti
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Neurosurg Focus 28:E7. 2010
    ..The complications and radiographic outcomes were compared with a posterior-only approach for scoliosis correction...
  83. doi Elongation of the body in eels
    Rita S Mehta
    Department of Ecology and Evolutionary Biology, 100 Schaffer Road, University of California, Santa Cruz, CA 95060, USA
    Integr Comp Biol 50:1091-105. 2010
    ..Lastly, we point out that a diverse range of derived behaviors such as head- and tail-first burrowing, rotational feeding, and knotting around prey are only found in long cylindrical vertebrates...
  84. ncbi Hox genes and the evolution of vertebrate axial morphology
    A C Burke
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 121:333-46. 1995
    ..The recognition of mechanistic homology supports the historical homology of basic patterning mechanisms between all organisms that share these genes...
  85. pmc Comparative anatomical dimensions of the complete human and porcine spine
    Iris Busscher
    Department of Orthopaedics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Eur Spine J 19:1104-14. 2010
    ..The porcine spine is said to be the most representative model for the human spine but a complete anatomical comparison is lacking...
  86. doi Spinal instability neoplastic score: an analysis of reliability and validity from the spine oncology study group
    Daryl R Fourney
    University of Saskatchewan, Royal University Hospital, 103 Hospital Dr, Saskatoon, Saskatchewan, Canada
    J Clin Oncol 29:3072-7. 2011
    ..The objective of this study was to determine the interobserver reliability, intraobserver reliability, and predictive validity of the Spinal Instability Neoplastic Score (SINS)...
  87. doi Biomechanical comparison of fusionless growth modulation corrective techniques in pediatric scoliosis
    Mark Driscoll
    Ecole Polytechnique de Montreal, Mechanical Engineering Department, Montreal, Canada
    Med Biol Eng Comput 49:1437-45. 2011
    ..This study critically explores different implants utilizing a human spine scoliotic finite element model (FEM)...
  88. doi Accuracy and repeatability of a new method for measuring scoliosis curvature
    Jia Wei He
    Department of Radiology, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, People s Republic of China
    Spine (Phila Pa 1976) 34:E323-9. 2009
    ..A prospective diagnostic clinical trial...
  89. ncbi The bent spine syndrome: myopathy + biomechanics = symptoms
    Andrew J Haig
    The Spine Program, The University of Michigan, 325 E Eisenhower, Ann Arbor, 48108, USA
    Spine J 6:190-4. 2006
    The bent spine syndrome, which mimics spinal stenosis, is thought to be a focal paraspinal myopathy, but because paraspinal fatigue with ambulation is not a feature of more severe myopathies, the cause of symptoms is not clear.
  90. pmc Clinical utility of spine bone density in elderly women
    Diane L Schneider
    Department of Medicine, University of California, San Diego, La Jolla, CA, USA
    J Clin Densitom 9:255-60. 2006
    It is common clinical practice to obtain a bone density measurement at both the hip and spine to evaluate osteoporosis...
  91. ncbi Epidemiology and risk factors for spine pain
    Devon I Rubin
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurol Clin 25:353-71. 2007
    ..Risk factors for developing spine pain are multidimensional; physical attributes, socioeconomic status, general medical health and psychologic state,..
  92. pmc Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling
    Kelly A Jones
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:19575-80. 2009
    ..associated with several psychiatric disorders, conditions that are also associated with aberrations in dendritic spine morphogenesis...
  93. doi Surgical management of unknown primary tumors metastatic to the spine
    Michele R Aizenberg
    Division of Neurosurgery, The University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Neurosurg Spine 16:86-92. 2012
    ..Patients presenting with spinal metastases from unknown primary tumors (UPTs) are rare. The authors reviewed their surgical experience to evaluate outcomes and identify predictors of survival in these patients...
  94. ncbi Gravity line analysis in adult volunteers: age-related correlation with spinal parameters, pelvic parameters, and foot position
    Frank Schwab
    Maimonides Medical Center, Brooklyn, NY, USA
    Spine (Phila Pa 1976) 31:E959-67. 2006
    ..Prospective radiographic and forceplate analysis in adult volunteers...
  95. doi Magnetic resonance imaging of the spine at 3 Tesla
    Peter Fries
    Clinic for Diagnostic and Interventional Radiology, Saarland University Hospital, Homburg Saar, Germany
    Semin Musculoskelet Radiol 12:238-52. 2008
    ..Particular benefits are seen in diagnostic imaging of the spine where MRI is clearly superior to both conventional radiography and computed tomography...
  96. pmc Neurogranin enhances synaptic strength through its interaction with calmodulin
    Ling Zhong
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
    EMBO J 28:3027-39. 2009
    ..Moreover, knocking-down Ng blocked LTP induction. Thus, Ng-CaM interaction can provide a mechanistic link between induction and expression of postsynaptic potentiation...
  97. pmc Image-guided spine surgery: state of the art and future directions
    Thorsten Tjardes
    Department for Trauma and Orthopedic Surgery, Cologne Merheim Medical Center, University of Witten Herdecke, Ostmerheimerstrasse 200, 51109 Cologne, Germany
    Eur Spine J 19:25-45. 2010
    Navigation technology is a widely available tool in spine surgery and has become a part of clinical routine in many centers. The issue of where and when navigation technology should be used is still an issue of debate...
  98. doi Vertebral morphometry
    Daniele Diacinti
    Department of Radiology, University Sapienza, Policlinico Umberto I, Viale Regina Elena 324, Rome, Italy
    Radiol Clin North Am 48:561-75. 2010
    ..fracture assessment (VFA) indicates the method for identification of the vertebral fractures using lateral spine views acquired by DXA, with low-dose exposition...
  99. doi Early complications in spine surgery and relation to preoperative diagnosis: a single-center prospective study
    Sanjay Yadla
    Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neurosurg Spine 13:360-6. 2010
    The reported incidence of complications in spine surgery varies widely...
  100. pmc Drivers of surgery for the degenerative hip, knee, and spine: a systematic review
    S Samuel Bederman
    Department of Orthopaedic Surgery, University of California at Irvine, 101 The City Drive South, Pavilion III, Orange, CA 92868, USA
    Clin Orthop Relat Res 470:1090-105. 2012
    Surgical treatment for degenerative conditions of the hip, knee, and spine has an impact on overall healthcare spending. Surgical rates have increased dramatically and considerable regional variation has been observed...
  101. pmc Adverse events in spine surgery in Sweden: a comparison of patient claims data and national quality register (Swespine) data
    Annica Ohrn
    Department of Medical and Health Sciences, Linkoping University, Sweden
    Acta Orthop 82:727-31. 2011
    ..We therefore investigated adverse events in spine surgery in Sweden by comparing patient claims data from the County Councils' Mutual Insurance Company register ..

Research Grants81

  1. Tibor T Glant; Fiscal Year: 2016
    ..PGISpA is the only inducible model of AS in which spine involvement is associated with sacroiliitis, uveitis and frequently but not always peripheral arthritis...
  2. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..a disease with flakey skin, and can be associated with arthritis of joints of hands, wrist, feet, ankle, knee, and spine. Nearly 2% of American population has psoriasis and 8-10% of psoriasis patients develop psoriatic arthritis...
  3. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..calcium absorption and bone remodeling to preclude the development of osteoporosis and resulting fractures of the spine, hip and wrist, the manner through which the vitamin D hormone accomplishes this beneficial effect has not been ..
  4. Epigenetics of Sex Differences in Brain and Behavior
    BRIDGET NUGENT; Fiscal Year: 2012
    ..The density of dendritic spine synapses within the POA is 2-3 times higher in males and hormonally masculinized females compared to control ..
  5. MARK L DELL'ACQUA; Fiscal Year: 2016
    ..during induction of long term potentiation (LTP) in hippocampal neurons through pathways that also increase spine size and actin polymerization...
  6. Subhash C Pandey; Fiscal Year: 2014
    ..Recently, it has been shown that BDNF can regulate both dendritic spine morphology and function by modulating the function of microRNAs (miRNAs) and its targets, p250GAP, a GTPase ..
  7. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    ..transgenic mice expressing SIRT1 show enhanced deacetylation of FOXO1 in bone, increased bone mass in the spine and femur and increased osteoblast but decreased osteoclast numbers...
  8. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..two functions: 1) strengthening of the adhesive nature of the synapse and morphological remodeling to generate a spine and 2) recruitment of NMDA type glutamate receptor transport packets via an actin-dependent transport mechanism...
  9. Subhash C Pandey; Fiscal Year: 2016
    ..neurotrophic factor (BDNF), activity-regulated cytoskeleton-associated protein (Arc) expression, and dendritic spine density (DSD) were lower in the central (CeA) and medial nucleus of amygdala (MeA) but not basolateral amygdala (..
  10. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ..mice reduce hippocampal size and spatial memory performance in short days;short days decrease apical CA1 spine density and increase basilar CA3 spine density suggesting that photoperiod, encoded by melatonin, alters brain ..
  11. Dopamine's Role in the Rapid Estradiol Enhancement of Excitatory Synapses
    CAROLINE COFER SMITH HAMILTON; Fiscal Year: 2013
    ..Moreover, I was able to demonstrate a correlative relationship between a morphological increase in dendritic spine density and LTP magnitude...
  12. Salivary-based Bone-loss Marker Detection Platform for Point-of-Care Screening
    MANAL BESHAY; Fiscal Year: 2012
    ..particularly in older women, it is usually only diagnosed at a later stage when morbid symptoms, such as spine or hip fractures, have occurred...
  13. Catherine M Gordon; Fiscal Year: 2015
    ..mitigated bone loss of the axial skeleton as evidenced by dual-energy x-ray absorptiometry (DXA) measures of the spine and whole body...
  14. Ephrin-A3 in Neuron-Glia Communication
    Elena B Pasquale; Fiscal Year: 2011
    ..This may represent a mechanism regulating spine remodeling during learning and memory formation...
  15. ALBERT HONG JAE KIM; Fiscal Year: 2016
    ..The second aim will elucidate a Cdc20-APC signaling pathway to the cohesion complex in dendrite and dendritic spine morphogenesis...
  16. Ara Nazarian; Fiscal Year: 2014
    ABSTRACT Fragility fractures of the hip, spine or wrist affect 1.5 million Americans annually and are a common cause of pain, deformity and disability. Moreover, caring for these fracture patients costs nearly $10 billion annually...
  17. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..has understandably been paid to the possible long-term complications of radiation therapy to the brain and spine of a growing child...
  18. Assessment of Bone Composition Through a Novel Liquid/Solid State MRI Method
    Ara Nazarian; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Fragility fractures of the hip, spine or wrist affect 1.5 million Americans annually and are a common cause of pain, deformity and disability...
  19. Gregory A Clines; Fiscal Year: 2016
    ..This phenotype was limited to the appendicular skeleton, sparing cortical bone and the spine. ET-1 expression in bone was restricted to vascular endothelium and correlated with the skeletal locations ..
  20. MERYL SUSAN LEBOFF; Fiscal Year: 2016
    ..with measures at baseline and year 2: Aim 1: High-dose vitamin D3 will (a) produce small increases in aBMD at the spine, hip, forearm and total body, as assessed by DXA and (b) improve balance of bone remodeling through decreases in ..
  21. Scott J Russo; Fiscal Year: 2016
    ..In addition, and consistent with findings in defeated mice, IKKca increases dendritic spine number and IKKdn decreases dendritic spine number on NAc medium spiny neurons...
  22. Adi Cohen; Fiscal Year: 2015
    ..resistance to the pathogenesis of premenopausal IOP and the response to TPTD assessed by 12 month increase in spine BMD...
  23. Dissecting the role of one neuronal RhoGEF amongst many: the Kalirin-7 null mouse
    Richard E Mains; Fiscal Year: 2012
    ..Rho GEF protein, are associated with increased iNOS levels in Alzheimer's disease brain and with decreased spine density in post-mortem prefrontal cortex from schizophrenic patients...
  24. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..and appendicular lean mass (kg), % lean mass, bone mineral content (g), and bone mineral density (BMD) at the spine and hip (g/cm2), in 228 overweight/obese postmenopausal women (50-75 y) undergoing a 12-month lifestyle change ..
  25. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    Tariq M Haqqi; Fiscal Year: 2010
    ..OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips...
  26. SK channels: Roles and mechanisms for dendritic excitability and plasticity
    James G Maylie; Fiscal Year: 2012
    ..However, our new data show that SK2 channels in the spine are also localized within the postsynaptic density of CA1 neurons and are down regulated in a pathway-specific and ..
  27. DANIEL HIGGINS EBERT; Fiscal Year: 2014
    ..identified as a site of activity-dependent phosphorylation that regulates activity-induced Bdnf expression, spine maturation, and dendritic arborization...
  28. Subhash C Pandey; Fiscal Year: 2016
    ..Arc) protein, and NMDA receptor subunits (NR2A&2B) are involved in regulating dendritic spine density (DSD) in the brain and are epigenetically controlled by histone acetylation and DNA methylation...
  29. Julie Paik; Fiscal Year: 2016
    ..Vertebral deformities will be assessed by vertebral fracture assessment, which images the lateral spine using x-ray absorptiometry, and is a reliable and accurate technique for identifying vertebral deformities and VF ..
  30. Guojun Bu; Fiscal Year: 2016
    ..forebrain knockout (LRP1-KO) mice have decreased brain cholesterol, sulfatide and cerebroside;reduced dendritic spine density and branching; fewer synapses;and diminished synaptic functions...
  31. Mriganka Sur; Fiscal Year: 2016
    ..use two-photon imaging of neurons and their dendrites across time in vivo to evaluate structural correlates of spine maturation...
  32. Darell D Bigner; Fiscal Year: 2016
    ..cells within the leptomeningeal space and metastatic spread through the cerebrospinal fluid along the brain and spine. NM from carcinoma of the breast and lung are the most common subtypes...
  33. Robust BCT for Clinical Use
    DAVID KOPPERDAHL; Fiscal Year: 2010
    ..analysis to many types of CT exams taken for other purposes such as CT colonography, pelvic, abdominal, and spine exams, thus reducing hospital costs, incurring no addition radiation to the patient, requiring no change in the CT ..
  34. Kristen M Harris; Fiscal Year: 2015
    ..endoplasmic reticulum for calcium regulation and protein trafficking;polyribosomes, Golgi outposts, and spine apparatuses for local protein synthesis;recycling and sorting endosomes for redistribution and degradation of ..
  35. MECHANISMS OF CHONDROPROTECTION BY POMEGRANATE FRUIT EXTRACT
    Tariq M Haqqi; Fiscal Year: 2011
    ..OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips...
  36. Alpaslan Dedeoglu; Fiscal Year: 2014
    ..that flavonoids improved spatial memory and this effect was associated with increased angiogenesis and neuronal spine density in the dentate gyrus of the hippocampus in mice...
  37. Chris B Schaffer; Fiscal Year: 2014
    ..In addition, activation of these cells has been associated with elevated rates of synaptic spine turnover, but without a change in overall spine density...
  38. Rapid ischemic tolerance: Synaptic re-organization and reduced excitotoxicity
    Robert Meller; Fiscal Year: 2012
    ..SPECIFIC AIM THREE: Test the hypothesis that dendritic spine loss, actin re-organization and NMDA protection is a common phenotype following pharmacological as well as ..
  39. Distance-Dependent Structure and Function of Neuronal Dendrites
    Kristen M Harris; Fiscal Year: 2010
    ..Different spines contained endosomes from those containing SER. Only large, mature spines contained a spine apparatus, which is similar to the Golgi apparatus...
  40. Molecular mechanisms of neural plasticity in drug addiction
    LAURA NICOLE SMITH; Fiscal Year: 2010
    ..Recently, it has been shown that chronic cocaine exposure regulates spine density in the nucleus accumbens, the brain's reward center, via cyclic-adenosine monophosphate (cAMP)-..
  41. Vitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on Fractures
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..fractures? Secondary Aims: In the CTSC sub-cohort, will vitamin D3 and/or EPA+DHA reduce bone loss of the spine, hip, and total body, as assessed by Dual X-ray Absorptiometry at baseline and year 2 and do effects vary with (a) ..
  42. Fragile X and Synaptic Plasticity
    Julie C Lauterborn; Fiscal Year: 2012
    ..Further results indicate that both drugs also reverse measures of aberrant spine morphology in the KOs. The proposed research will build on these findings in 4 specific aims...
  43. Claudio D Stern; Fiscal Year: 2015
    ..Perturbations can lead to malformations of the spine ranging from complete disarray of the vertebral elements (e.g...
  44. SK2 Channels as Novel Neuroprotective Targets Against Cerebral Ischemia
    Paco S Herson; Fiscal Year: 2012
    ..3. CA/CPR-induced ischemia causes PKA phosphorylation of spine SK2 channels, inducing channel endocytosis...
  45. Estrogen and hippocampal plasticity
    LORI LYNN MCMAHON; Fiscal Year: 2012
    ..At hippocampal CA3-CA1 synapses, estradiol (E2) increases spine density, NMDAR transmission, and LTP5-8, mechanisms believed to underlie the enhanced memory...
  46. Synthesis of bone-selective osteogenic oxysterols
    Frank Stappenbeck; Fiscal Year: 2013
    ..including in mouse and human primary MSCs, and it stimulates robust localized bone formation in vivo in a rat spine fusion model...
  47. Joanne M Jordan; Fiscal Year: 2015
    ..individuals will complete radiographic examinations of the knees, hips, patellofemoral joints, hands, and lumbar spine, physical and functional examination, extensive interviews, and DEXA, and contribute urine and blood for storage ..
  48. Regulation of AKAP79 Postsynaptic Targeting and Signaling
    MARK L DELL'ACQUA; Fiscal Year: 2013
    ..Importantly, we found that a palmitoylation deficient AKAP mutant altered regulation of spine enlargement, endosome recycling, and GluA1 trafficking associated with LTP...
  49. "Gdf6 gene expression and evolution in vertebrates"
    Douglas Mortlock; Fiscal Year: 2009
    ..In mouse, Gdf6 is important for normal development of limb, ear, skull and spine skeletal joints, the larynx, and potentially other structures including the heart...
  50. Iryna M Ethell; Fiscal Year: 2016
    ..Defects in dendritic spine morphology have been found in the brains of patients with neurodevelopmental disorders associated with mental ..
  51. Piyush M Patel; Fiscal Year: 2016
    ..tPA;tPA restores signaling through TrkB receptors, leading to the activation of Akt, increased dendritic spine formation and neuronal survival...
  52. Robert A Sweet; Fiscal Year: 2016
    ..Soluble A( can cause spine loss by shifting the balance of post-synaptic signaling within spines from pathways supporting long-term ..
  53. Bone Marrow Adiposity, Bone and Body Composition
    Ann V Schwartz; Fiscal Year: 2012
    ..marrow adiposity measured by MRS is associated with cortical and trabecular bone density and bone size at the spine, hip and femoral shaft measured by CT;with areal bone density of the hip and spine from DXA;and with bone turnover ..
  54. Cytoskeletal Dynamics in Neuronal Dendrites
    Erik W Dent; Fiscal Year: 2013
    ..Actin filaments (f-actin) play prominent roles in the formation, maintenance and plasticity of dendritic spine structure...
  55. Crosby_Gregory_Mechanisms of Post-Anesthetic CNS Dysfunction in Aging
    Gregory Crosby; Fiscal Year: 2012
    ..well-characterized in vivo model, we propose to systematically examine anesthetic effects on dendritic spine morphogenesis, synaptogenesis, and neurogenesis to test the hypotheses that isoflurane but not propofol 1...
  56. Genetics of Bone Structure and Metabolism
    Michael C Mahaney; Fiscal Year: 2013
    ..bone ultrasound attenuation of the calcaneous, bone mineral densities in 3 regions (proximal femur, lumbar spine, and forearm) assessed using dual-energy X-ray absorptiometry, and 12 biomarkers related to bone formation, turn-..
  57. Early effects of PTH on the proximal femur
    Felicia Cosman; Fiscal Year: 2013
    ..While BMD changes are smaller and slower in the hip in response to TPTD than in the spine, it is possible that stimulation of bone formation on the periosteal bone surface could result in expansion of ..
  58. Kimberly Huber; Fiscal Year: 2016
    ..Importantly, sensory experience and circuit activity drives the pruning of spines in vivo. Spine elimination is also triggered by learning in adults and may mediate the refinement of circuits that maintain ..
  59. RONALD ROBERT SEESE; Fiscal Year: 2015
    ..for autism, such Fragile X, Rett, and Angelman Syndromes, there are significant abnormalities in dendritic spine morphology, which are associated with impairments in the stabilization of long-term potentiation (LTP), a synaptic ..
  60. Ultrasound Ablation on Bone Cancer Under CT Fluoroscopy
    Everette C Burdette; Fiscal Year: 2012
    ..Current options for local treatment of metastatic spine cancer are insufficient...
  61. Hippocampal dendritic spines tracked in learning and memory processing using in v
    Mark J Schnitzer; Fiscal Year: 2012
    ..Both learning and diseases that impair memory function can alter hippocampal spine density...
  62. Investigating the RhoA/ROCK pathway for the treatment of Alzheimer's disease
    JEREMY HARTFORD HERSKOWITZ; Fiscal Year: 2013
    ..that activation or inhibition of RhoA reflects ROCK2-mediated effects in brain by measuring changes in dendritic spine morphology as well as A[unreadable] production following pharmacological modulation of RhoA activity coupled with ..
  63. Variation in the Safety of Back Pain-Related Surgery
    Sohail K Mirza; Fiscal Year: 2010
    ..and examine hospital/surgeon characteristics associated with rates of repeat surgery higher than those in the Spine Patient Outcomes Research Trial (SPORT), the largest clinical trial ever funded by NIAMS (2,472 patients, 53 elite ..
  64. OSTEOARTHRITIS & OSTEOPOROSIS IN ELDERLY WOMAN
    Michael Nevitt; Fiscal Year: 1992
    ..bone mass in the hip in relation to hip OA, bone mass in the radius in relation to hand OA, and bone mass in the spine in relation to spine OA...
  65. PATHOGENESIS OF DISEASE IN MUCOPOLYSACCHARIDOSIS I AND VII
    Katherine P Ponder; Fiscal Year: 2010
    ..of proteases that degrade these proteins is a common pathophysiological pathway to disease in aorta and spine. Aortas undergo elastin fragmentation and progressive dilatation, which can result in cardiovascular insufficiency ..
  66. Clinical Validation of BCT - Phase II
    DAVID KOPPERDAHL; Fiscal Year: 2010
    ..bone density, body-weight, height, trochanteric soft tissue thickness (for hip fractures), muscle moment arm (for spine), and the age-related risk of sustaining an overload event (such as a fall or lifting of a heavy object with back ..
  67. BACK PAIN OUTCOME ASSESSMENT TEAM
    Richard Deyo; Fiscal Year: 1991
    ..The specific aims of the Team are to (1) characterize geographic variation and outcomes of lumbar spine surgery; (2) characterize the content and outcome of non-surgical hospitalizations for back problems; (3) examine ..
  68. Innovative Tools for In Vivo Computational Prediction of Lumbar Stresses
    RICHARD DAVID KOMISTEK; Fiscal Year: 2010
    ..and implementing in vivo kinematics using X- ray fluoroscopy, CT scans for bone modeling and MRIs of the lumbar spine for soft-tissue evaluation as input to our mathematical models;2) computing the forces at the spine interfaces ..
  69. Reducing Low-back Disorders Using a New Sitting Design
    Mohsen Makhsous; Fiscal Year: 2003
    ..risk factors for LBP include sustained static muscle load, and inappropriate curvature/position of the spine and pelvis...
  70. CLINICAL BIOMECHANICS OF CERVICAL SPINE
    Manohar Panjabi; Fiscal Year: 1990
    Trauma, rheumatoid arthritis, and degeneration are the major problems in the upper cervical spine (occiput-C1-C2 joint complex). They result in pain, deformity and neurological dysfunction...
  71. BIOMECHANICS OF VERTEBRAL FRACTURES IN OSTEOPOROSIS
    WHITSON EDWARDS; Fiscal Year: 1991
    ..bone disease associated with losses in bone volume and increases in the risk of spontaneous fractures of the spine, hip, and radius. Millions of post-menopausal women are particularly at risk...
  72. Aminocaproic Acid and Bleeding in Spinal Surgery
    Sean Berenholtz; Fiscal Year: 2006
    ..preoperative patient or hospital characteristics that predict allogeneic transfusion in adult patients undergoing spine surgery in Maryland from 1997 to 2000...
  73. MANUAL PALPATION OF INTERVERTEBRAL MOTION
    Martin Krag; Fiscal Year: 1993
    This study will form a basis for an investigation of the biomechanical responses of the lumbar spine to chiropractic manual palpation...
  74. MULTISCAN PHOTON ABSORPTIOMETRY & OSTEOPOROTIC FRACTURE
    Wilson Hayes; Fiscal Year: 1991
    ..number of studies have shown BMC of the distal radius to be a relatively weak predictor of fracture of the hip and spine and thus, in recent years, dual photon absorptiometry (DPA) and dual energy x-ray absorptiometry (DEXA) of the ..
  75. Biomechanics of Spine Fracture
    TONY KEAVENY; Fiscal Year: 2007
    ..Currently, the clinical gold standard for assessment of fracture risk for the spine is dual-energy x-ray absorptiometry (DXA)...
  76. Dendritic Repulsion by the EphA4 Receptor
    Elena Pasquale; Fiscal Year: 2006
    ..However, the factors that regulate spine motility and organization remain unclear...
  77. NIAMS Muiltidisciplinary Clinical Research Center in...
    Richard Deyo; Fiscal Year: 2006
    The University of Washington proposes a Multidisciplinary Clinical Research Center devoted to the study of spine and upper extremity disorders...