bony callus

Summary

Summary: The bony deposit formed between and around the broken ends of BONE FRACTURES during normal healing.

Top Publications

  1. ncbi Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation
    Louis C Gerstenfeld
    Department of Orthopaedic Surgery, Orthopaedic Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118 2526, USA
    J Cell Biochem 88:873-84. 2003
  2. ncbi The effect of micromovement on callus formation
    T Yamaji
    Department of Orthopaedic Surgery, Fujita Health University, 3-6-10 Otobashi, Nakagawa-ku, Nagoya 454-8509, Japan
    J Orthop Sci 6:571-5. 2001
  3. ncbi The role of bone marrow-derived cells in bone fracture repair in a green fluorescent protein chimeric mouse model
    Kazuhiro Taguchi
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Biochem Biophys Res Commun 331:31-6. 2005
  4. pmc Teriparatide improves early callus formation in distal radial fractures
    Per Aspenberg
    Division of Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop 81:234-6. 2010
  5. ncbi Remodeling of fracture callus in mice is consistent with mechanical loading and bone remodeling theory
    Hanna Isaksson
    AO Research Institute, Davos, Switzerland
    J Orthop Res 27:664-72. 2009
  6. ncbi Bone remodeling during fracture repair: The cellular picture
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    Semin Cell Dev Biol 19:459-66. 2008
  7. pmc Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Bone 44:335-44. 2009
  8. ncbi Application of histomorphometric methods to the study of bone repair
    Louis C Gerstenfeld
    Department of Orthopaedic Surgery, Orthopaedic Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Bone Miner Res 20:1715-22. 2005
  9. ncbi Eel calcitonin (elcatonin) suppressed callus remodeling but did not interfere with fracture healing in the femoral fracture model of cynomolgus monkeys
    Takeshi Manabe
    Department of Orthopedic Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    J Bone Miner Metab 27:295-302. 2009
  10. ncbi Locally applied simvastatin promotes fracture healing in ovariectomized rat
    J W Wang
    Department of Orthopaedics, The Second Affiliated Hospital, Medical School of Zhejiang University, No 88, Jiefang Road, Hangzhou, China 310009
    Osteoporos Int 18:1641-50. 2007

Research Grants

Detail Information

Publications181 found, 100 shown here

  1. ncbi Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation
    Louis C Gerstenfeld
    Department of Orthopaedic Surgery, Orthopaedic Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118 2526, USA
    J Cell Biochem 88:873-84. 2003
    ....
  2. ncbi The effect of micromovement on callus formation
    T Yamaji
    Department of Orthopaedic Surgery, Fujita Health University, 3-6-10 Otobashi, Nakagawa-ku, Nagoya 454-8509, Japan
    J Orthop Sci 6:571-5. 2001
    ..Large gaps showed the least new bone formation at the fracture site and the lowest flexural rigidity. From the histological analysis, it was found that the flexural rigidity correlated with the new bone area in the periosteal region...
  3. ncbi The role of bone marrow-derived cells in bone fracture repair in a green fluorescent protein chimeric mouse model
    Kazuhiro Taguchi
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Biochem Biophys Res Commun 331:31-6. 2005
    ..We suggest that bone marrow cells migrated outside of the bone marrow and differentiated into osteoblasts to make up the calluses...
  4. pmc Teriparatide improves early callus formation in distal radial fractures
    Per Aspenberg
    Division of Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop 81:234-6. 2010
    ..As radiographic cortical continuity appears late in the healing process, perhaps too late for clinical relevance, we studied the qualitative appearance of the callus 5 weeks after fracture...
  5. ncbi Remodeling of fracture callus in mice is consistent with mechanical loading and bone remodeling theory
    Hanna Isaksson
    AO Research Institute, Davos, Switzerland
    J Orthop Res 27:664-72. 2009
    ....
  6. ncbi Bone remodeling during fracture repair: The cellular picture
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    Semin Cell Dev Biol 19:459-66. 2008
    ..Finally, the fourth section examines the effects of delaying osteoclast-dependent hard callus remodeling and also poses questions regarding the crosstalk between anabolism and catabolism in the latter stages of fracture repair...
  7. pmc Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Bone 44:335-44. 2009
    ..These findings form the basis for developing non-invasive assessments of fracture healing and for identifying biological and biomechanical mechanisms that lead to impaired or enhanced healing...
  8. ncbi Application of histomorphometric methods to the study of bone repair
    Louis C Gerstenfeld
    Department of Orthopaedic Surgery, Orthopaedic Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Bone Miner Res 20:1715-22. 2005
    ....
  9. ncbi Eel calcitonin (elcatonin) suppressed callus remodeling but did not interfere with fracture healing in the femoral fracture model of cynomolgus monkeys
    Takeshi Manabe
    Department of Orthopedic Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    J Bone Miner Metab 27:295-302. 2009
    ..In conclusion, mild suppression of callus remodeling by elcatonin did not impair overall fracture healing process. In contrast, alendronate delayed structural fracture healing process by strongly suppressing callus remodeling...
  10. ncbi Locally applied simvastatin promotes fracture healing in ovariectomized rat
    J W Wang
    Department of Orthopaedics, The Second Affiliated Hospital, Medical School of Zhejiang University, No 88, Jiefang Road, Hangzhou, China 310009
    Osteoporos Int 18:1641-50. 2007
    ..Results showed that locally applied simvastatin improved fracture healing...
  11. ncbi Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing
    Louis C Gerstenfeld
    Orthopaedic Research Laboratory, Department of Orthopedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Bone Miner Res 24:196-208. 2009
    ..In contrast, strength and stiffness were enhanced in these treatment groups compared with control bones...
  12. ncbi Impaired fracture healing in macrophage migration inhibitory factor-deficient mice
    T Kobayashi
    Department of Sports Medicine and Joint Reconstruction Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Osteoporos Int 22:1955-65. 2011
    ..Fracture healing was delayed in MIF KO, and this was mainly due to the delay in the mineralization of osteoid within the fracture callus...
  13. pmc Reduced COX-2 expression in aged mice is associated with impaired fracture healing
    Amish A Naik
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
    J Bone Miner Res 24:251-64. 2009
    ..The findings suggest that COX-2/EP4 agonists may compensate for deficient molecular signals that result in the reduced fracture healing associated with aging...
  14. pmc Recent advances in the use of serological bone formation markers to monitor callus development and fracture healing
    Marlon O Coulibaly
    Grand Rapids Medical Education and Research Center, Michigan, USA
    Crit Rev Eukaryot Gene Expr 20:105-27. 2010
    ..We also review the role and potential of serum PINP, as well as other markers, as indications of fracture healing...
  15. pmc Correlations between local strains and tissue phenotypes in an experimental model of skeletal healing
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    J Biomech 43:2418-24. 2010
    ..These results indicate that shear strain may be an important regulator of tissue fate during skeletal healing...
  16. pmc Rejuvenation of the inflammatory system stimulates fracture repair in aged mice
    Zhiqing Xing
    Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California at San Francisco, 2550 23rd Street, Bldg 9, Rm 345, San Francisco, California 94110, USA
    J Orthop Res 28:1000-6. 2010
    ..Thus, the roles of inflammatory cells in fracture healing may be age-related, suggesting the possibility of enhancing fracture healing in aged animals by manipulating the inflammatory system...
  17. ncbi α(1) adrenergic receptor agonist, phenylephrine, actively contracts early rat rib fracture callus ex vivo
    Stuart J McDonald
    Musculoskeletal Research Centre, School of Human Biosciences, La Trobe University, Victoria 3086, Australia
    J Orthop Res 29:740-5. 2011
    ..We propose that increased concentrations of α(1) AR agonists such as noradrenaline may tonically contract callus in vivo to promote osteogenesis...
  18. ncbi Early fracture callus displays smooth muscle-like viscoelastic properties ex vivo: implications for fracture healing
    Stuart J McDonald
    School of Human Biosciences, Musculoskeletal Research Centre, La Trobe University, Victoria 3086, Australia
    J Orthop Res 27:1508-13. 2009
    ....
  19. pmc Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation - role of a local renin-angiotensin system
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Br J Pharmacol 159:1672-80. 2010
    ..Therefore, we studied the expression and function of the key RAS component, angiotensin-converting enzyme (ACE), during fracture healing...
  20. pmc Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4
    Chao Xie
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Pathol 175:772-85. 2009
    ..The EP4 agonist markedly improved the impaired healing in COX-2(-/-) mice, as evidenced by restoration of bony callus formation on day 14, a near complete reversal of bone formation, and an approximately 70% improvement of ..
  21. ncbi Molecular basis for affected cartilage formation and bone union in fracture healing of the streptozotocin-induced diabetic rat
    Akira Ogasawara
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Bone 43:832-9. 2008
    ..These results show the molecular basis for diminished cartilage formation and delayed union in fracture healing of the STZ-induced diabetic rats...
  22. pmc Modulation of Wnt signaling influences fracture repair
    David E Komatsu
    InMotion Orthopaedic Research Center, 20 South Dudley, Suite 700, Memphis, Tennessee 38103, USA
    J Orthop Res 28:928-36. 2010
    ..Furthermore, these data suggest that activation of Wnt signaling during fracture repair may have clinical utility in facilitating fracture repair...
  23. ncbi Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model
    David G Little
    Orthopaedic Research and Biotechnology, University of Sydney, Discipline of Paediatrics and Child Health, The Children s Hospital at Westmead, Westmead, Australia
    J Bone Miner Res 20:2044-52. 2005
    ..In a rat critical defect, this combination therapy produced significant increases in new bone volume and strength...
  24. pmc Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice
    Xu Yang
    The Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
    Bone 41:928-36. 2007
    ..These effects were transient indicating that the role of IL-6 appears to be most important in the early stages of fracture healing...
  25. ncbi Radiographic classification of osteogenesis during bone distraction
    Ru Li
    Academic Unit of Orthopaedics, Clinical Sciences North, University of Sheffield, Northern General Hospital, Sheffield, S5 7AU, United Kingdom
    J Orthop Res 24:339-47. 2006
    ..Hence, potential problems can be predicted and clinical changes made to improve outcome. The classification can be simplified to make it more appropriate for clinical use...
  26. pmc Cellular basis for age-related changes in fracture repair
    Chuanyong Lu
    Department of Orthopaedic Surgery, San Francisco General Hospital, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    J Orthop Res 23:1300-7. 2005
    ..22). Collectively, these data suggest that enhancing cell differentiation, improving osteoblast function, and accelerating endochondral ossification may significantly benefit the elderly...
  27. ncbi Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing
    Tetsuro Nakazawa
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8677, Japan
    Bone 37:711-9. 2005
    ..These results suggest that intermittent treatment with low-dose rhPTH(1-34) induces a larger cartilaginous callus but does not delay chondrocyte differentiation during fracture healing...
  28. pmc Secreted frizzled related protein 1 is a target to improve fracture healing
    Tripti Gaur
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 220:174-81. 2009
    ..Thus, developing an antagonist to specifically inhibit sFRP1 represents a safe target for stimulating fracture repair and bone formation in metabolic bone disorders, osteoporosis and aging...
  29. ncbi A model for intramembranous ossification during fracture healing
    Zachary Thompson
    Department of Orthopaedic Surgery, University of California at San Francisco, 94143 0514, USA
    J Orthop Res 20:1091-8. 2002
    ..Future studies will use this murine model of intramembranous fracture healing to explore, at a molecular level, how the mechanical environment exerts its influence on healing of a fracture...
  30. ncbi COX-1 and COX-2 expression in osteoid osteomas
    David V Mungo
    Department of Orthopaedics, Medical Center, University of Rochester, NY 14642, USA
    J Orthop Res 20:159-62. 2002
    ..These findings suggest that the newly selective COX-2 inhibitors could be used to more safely treat osteoid osteomas...
  31. ncbi Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing
    T Kon
    Department of Orthopedic Surgery, Boston University Medical Center, Massachusetts 02118, USA
    J Bone Miner Res 16:1004-14. 2001
    ....
  32. ncbi Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs
    Louis C Gerstenfeld
    Department of Orthopaedic Surgery, Orthopaedic Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    J Orthop Res 21:670-5. 2003
    ..They further demonstrate that a COX-2 selective NSAID, such as parecoxib (valdecoxib), has only a small effect on delaying fracture healing even at doses that are known to fully inhibit prostaglandin production...
  33. ncbi The effects of osteoporosis on distraction osteogenesis: an experimental study in an ovariectomised rabbit model
    H Arslan
    Department of Orthopaedic and Trauma Surgery, University of Dicle, School of Medicine, Diyarbakir, Turkey
    Acta Orthop Belg 69:67-73. 2003
    ..Nonetheless, radiographic findings in rabbits indicate that the effects may not be so great as to preclude clinical procedures. It was concluded that these results should be supported with clinical studies...
  34. ncbi Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair
    Negin Amanat
    Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Westmead, Australia
    J Bone Miner Res 22:867-76. 2007
    ..Delaying the dose (1 or 2 wk after fracture) displayed superior results compared with dosing at the time of fracture...
  35. ncbi Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing
    Ann Marie Simon
    Department of Orthopaedics, UMDNJ New Jersey Medical School, MSB G580 ORTHO, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Bone Joint Surg Am 89:500-11. 2007
    ..The goal of the present study was to determine how variations in nonsteroidal anti-inflammatory drug therapy ultimately affect fracture-healing...
  36. ncbi Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling
    Michelle M McDonald
    Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Westmead, Australia
    Bone 43:653-62. 2008
    ..We aimed to examine the effect of different dosing regimes of the potent BP zoledronic acid (ZA) on early endochondral fracture repair and later callus remodeling in a normal bone healing environment...
  37. ncbi Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice
    M Li
    Osteoporosis Research, Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, MS8118W 208, Groton, CT 06340, USA
    Bone 37:46-54. 2005
    ..KO mice had significant decreases in total callus area, cartilaginous callus area, and bony callus area 2 weeks after fracture. By 4 weeks, complete bony bridging was seen in WT mice but not in KO mice...
  38. ncbi Equol but not genistein improves early metaphyseal fracture healing in osteoporotic rats
    Leila Kolios
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Goettingen, Germany
    Planta Med 75:459-65. 2009
    ..Genistein rather negatively influenced fracture healing. The metaphyseal osteotomy model in ovariectomized rats allows an accurate study of the therapeutic effects of antiosteoporotic substances on the fracture healing process...
  39. pmc Diminished bone formation during diabetic fracture healing is related to the premature resorption of cartilage associated with increased osteoclast activity
    Rayyan A Kayal
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Bone Miner Res 22:560-8. 2007
    ..Increased cartilage turnover was associated with elevated osteoclast numbers, a higher expression of genes that promote osteoclastogenesis, and diminished primary bone formation...
  40. ncbi Models of tibial fracture healing in normal and Nf1-deficient mice
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, Reasearch Building, Locked Bag 4001, The Children s Hospital at Westmead, Sydney, NSW 2145, Australia
    J Orthop Res 26:1053-60. 2008
    ..These findings imply that the pathology of tibial pseudarthrosis in human NF1 is complex and likely to be multifactorial...
  41. ncbi Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone
    T T Andreassen
    Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Denmark
    Acta Orthop Scand 72:304-7. 2001
    ..In conclusion, PTH treatment enhances fracture strength, callus volume and callus BMC after 3 and 8 weeks of healing...
  42. ncbi Augmentation of bone healing by specific frequency and amplitude compressive strains
    Azadeh Shadmehr
    Department of Physical Therapy, Faculty of Rehabilitation, Medical Sciences University of Tehran, Tehran, Iran
    Orthopedics 32:173. 2009
    ..029). Both radiographic and mechanical measures were significantly higher after 3 weeks compared to 2 weeks of receiving stimulation (P<.05)...
  43. ncbi Gene expression in older rats with delayed union of femoral fractures
    Ralph A Meyer
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, North Carolina 28232, USA
    J Bone Joint Surg Am 85:1243-54. 2003
    ..The objective of this study was to examine the possible role of altered mRNA gene expression in this delayed union...
  44. ncbi FGF23 is a putative marker for bone healing and regeneration
    Sascha Goebel
    Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany
    J Orthop Res 27:1141-6. 2009
    ..In conclusion, FGF23 is involved in bone healing, can be measured by a sensitive assay in peripheral blood, and is a promising candidate as an indicator for healing processes prone to reunion versus nonunion...
  45. ncbi Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34)
    Arata Nakajima
    Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, Japan
    J Bone Miner Res 17:2038-47. 2002
    ..The resultant effect to increase callus mechanical strength supports the concept that clinical investigations on the ability of injectable low-dose PTH(1-34) to enhance fracture healing are indicated...
  46. ncbi Mechanical stimulation by external application of cyclic tensile strains does not effectively enhance bone healing
    P Augat
    Institute of Orthopedic Research and Biomechanics, University of Ulm, Germany
    J Orthop Trauma 15:54-60. 2001
    ..To determine whether an externally induced interfragmentary movement enhances the healing process of a fracture under flexible fixation...
  47. ncbi Pharmacological inhibition of 5-lipoxygenase accelerates and enhances fracture-healing
    Jessica A Cottrell
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, MSB E 659 Biochem, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Bone Joint Surg Am 91:2653-65. 2009
    ..The goal of this study was to determine if systemic inhibition of 5-lipoxygenase with an orally delivered drug could accelerate fracture-healing...
  48. ncbi Quantitative trait loci for callus initiation and totipotency in maize (Zea mays L.)
    M D Krakowsky
    Department of Agronomy, Iowa State University, Ames, IA 50011, USA
    Theor Appl Genet 113:821-30. 2006
    ....
  49. ncbi 1Alpha,25-dihydroxy-2beta(3-hydroxypropoxy)vitamin D3 (ED-71) suppressed callus remodeling but did not interfere with fracture healing in rat femora
    Yongping Cao
    Department of Orthopedic Surgery, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Kita gun Kagawa 761 0793, Japan
    Bone 40:132-9. 2007
    ....
  50. ncbi Immunohistochemical localization of nerve growth factor in fractured and unfractured rat bone
    B L Grills
    School of Human Biosciences, Department of Physiology and Anatomy, La Trobe University, Bundoora, Victoria, Australia
    Acta Orthop Scand 69:415-9. 1998
    ..The presence of NGF in the callus may also indicate a direct, as yet undefined action of this neurotrophin on skeletal cell metabolism...
  51. ncbi Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats
    R A Meyer
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC 28232, USA
    J Orthop Res 19:428-35. 2001
    ..In conclusion, age and ovariectomy significantly impair the process of fracture healing in female rats as judged by measurements of rigidity and breaking load in three-point bending and by accretion of mineral into the fracture callus...
  52. ncbi Site-specific CGRP innervation coincides with bone formation during fracture healing and modeling: A study in rat angulated tibia
    Jian Li
    Section of Orthopaedics, Institution of Molecular Medicine and Surgery, Research Center M3 02, Karolinska University Hospital, SE 171 76, Stockholm, Sweden
    J Orthop Res 25:1204-12. 2007
    ..The combined results suggest that fracture evokes an intense, localized in-growth of new nerve fibers containing CGRP, which may prove to be a prerequisite of fracture healing and modeling...
  53. ncbi Effect of vascularity on canine distracted tibial callus consolidation
    Satoru Ohashi
    The Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
    Clin Orthop Relat Res 438:253-9. 2005
    ..Our results suggest that preservation of the higher density of blood vessels in the consolidation period could lead to the better mineralization of the distracted callus...
  54. ncbi Effect of strontium ranelate on fracture healing in rat tibia
    Oguz Cebesoy
    Gaziantep University Faculty of Medicine, Orthopedic and Traumatology Department, 27060 Gaziantep, Sahinbey, Turkey
    Joint Bone Spine 74:590-3. 2007
    ..Our objective in the present study is to investigate the efficacy of strontium ranelate (SR) on fracture healing in rat tibia...
  55. ncbi Staphylococcus aureus peptidoglycan impairs fracture healing: an experimental study in rats
    Olav Reikeras
    Department of Orthopaedics, Rikshospitalet Radiumhospitalet Medical Centre, University of Oslo, N 0027 Oslo, Norway
    J Orthop Res 25:262-6. 2007
    ..Collectively, these data show that SaPG induces an alteration in the normal bone healing response towards a less calcified callus production...
  56. ncbi Low-intensity pulsed ultrasound for bone healing: an overview
    Konstantinos N Malizos
    Department of Orthopaedic Surgery and Musculoskeletal Trauma, University Hospital of Larissa, School of Heath Sciences, University of Thessalia, Larissa, Greece
    Injury 37:S56-62. 2006
    ....
  57. ncbi Role of bone regeneration and turnover modulators in control of fracture
    Nimrod Rozen
    Department of Orthopaedic Surgery, Ha Emek Medical Center, Afula, Israel
    Crit Rev Eukaryot Gene Expr 17:197-213. 2007
    ..The aim of this article is to highlight events that contribute to and drive the dynamic healing process in order to help clinicians to find successful, novel treatment protocols...
  58. ncbi The effect of intermittent pneumatic compression on fracture healing
    John D Hewitt
    Orthopaedic Research Laboratories, Division of Orthopaedic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Orthop Trauma 19:371-6. 2005
    ..This study was designed to test the hypothesis that intermittently increased venous pressure improves fracture healing without injuring soft tissue...
  59. ncbi Transplantation of osteoblast-like cells to the distracted callus in the rabbit mandible
    Zhen Shao
    Department of Traumatic and Aesthetic Surgery, Huangsi Aesthetic Surgery Hospital, 9 Huangsi Street, Beijing 100011, People s Republic of China
    Plast Reconstr Surg 119:500-7. 2007
    ..The purpose of this study was to investigate whether injections of marrow-derived mesenchymal progenitor cells could be used to facilitate new bone formation during distraction osteogenesis...
  60. ncbi Effect of BMP-2 gene transfer on bone healing in sheep
    M Egermann
    AO Research Institute, Davos, Switzerland
    Gene Ther 13:1290-9. 2006
    ..This finding stands in contrast to the data obtained from small animal models. Further studies are needed to determine the contribution of the immune response to these results, and whether a lower dose of Ad.BMP-2 would be advantageous...
  61. ncbi CYR61 (CCN1) protein expression during fracture healing in an ovine tibial model and its relation to the mechanical fixation stability
    Jasmin Lienau
    Charite Universitatsmedizin Berlin, Free and Humboldt University of Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Orthop Res 24:254-62. 2006
    ..The results supply further evidence that CYR61 may serve as an important regulator of bone healing...
  62. ncbi Percutaneous autologous bone-marrow grafting for nonunions. Surgical technique
    Ph Hernigou
    Service de Chirurgie Orthopedique, Hopital Henri Mondor, 94010 Creteil, France
    J Bone Joint Surg Am 88:322-7. 2006
    ..The purpose of this study was to evaluate the number and concentration of progenitor cells that were transplanted for the treatment of nonunion, the callus volume obtained after the transplantation, and the clinical healing rate...
  63. ncbi Fracture healing assessment comparing stiffness measurements using radiographs
    D McClelland
    Department of Trauma and Orthopaedic Surgery, University Hospital of North Staffordshire, UK
    Clin Orthop Relat Res 457:214-9. 2007
    ..We found substantial intraobserver variability, which improved using cortical bridging methods. Observers were less reliable at predicting healing when there was a metaphyseal extension to a diaphyseal fracture...
  64. ncbi Hepatocyte growth factor contributes to fracture repair by upregulating the expression of BMP receptors
    Yuuki Imai
    Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Bone Miner Res 20:1723-30. 2005
    ..HGF facilitates the expression of BMPRs in mesenchymal cells. This study suggests that HGF contributes to fracture repair by inducing the expression of BMPRs...
  65. ncbi A simulated weightlessness state diminishes cortical bone healing responses
    R J Midura
    Department of Biomedical Engineering and Orthopaedic Research Center, Cleveland Clinic, Cleveland, OH 44195, USA
    J Musculoskelet Neuronal Interact 6:327-8. 2006
  66. ncbi Mice expressing a constitutively active PTH/PTHrP receptor in osteoblasts show reduced callus size but normal callus morphology during fracture healing
    Richard Marsell
    Department of Surgical Sciences, Uppsala University Hospital, Sweden
    Acta Orthop 78:39-45. 2007
    ..We have analyzed the bone phenotype and studied the fracture healing process in this model...
  67. ncbi Unexpected absence of effect of rhBMP-7 on distraction osteogenesis
    Frederic Sailhan
    Department of Pediatric Orthopaedics, Hôpital Debrousse Lyon, France
    Clin Orthop Relat Res 457:227-34. 2007
    ..We suggest the poor results related to the relatively large bulk of the solid carrier of the OP-1 that might have acted as a mechanical obstacle to osteogenesis...
  68. ncbi Three-dimensional reconstruction of fracture callus morphogenesis
    Louis C Gerstenfeld
    Orthopaedic Research Laboratory, Boston University Medical Center, 715 Albany Street, R 205, Boston, MA 02118, USA
    J Histochem Cytochem 54:1215-28. 2006
    ..These data further show that remodeling of the calcified cartilage produces a trabecular bone structure unique to fracture healing that provides the rapid regain in weight-bearing capacity to the injured bone...
  69. ncbi Stiffness measurement of the neocallus with the Fraktometer FM 100
    T Schmickal
    Berufsgenossenschaftliche Unfallklinik Ludwigshafen, Unfallchirurgische Klinik an der Universität Heidelberg, Ludwig Guttmann Str 11 13, 67071 Ludwigshafen, Germany
    Arch Orthop Trauma Surg 125:653-9. 2005
    ..The purpose of this study was to follow stiffness control at external fixator in healing of callotasis with the stiffness measurement system...
  70. ncbi Ultrasonographic and radiographic assessment of uncomplicated secondary fracture healing of long bones in dogs and cats
    Marije Risselada
    Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University Merelbeke, Belgium
    Vet Surg 34:99-107. 2005
    ..To evaluate the use of ultrasonography (US) to detect bone healing in uncomplicated diaphyseal fractures of dogs and cats, and to compare these observations with detection of healing by radiography (RG)...
  71. ncbi Local anabolic effects of growth hormone on intact bone and healing fractures in rats
    T T Andreassen
    Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Calcif Tissue Int 73:258-64. 2003
    ..External callus dimensions of the fractures were increased in the rGH group, whereas body weight changes during the healing period were not affected...
  72. ncbi Shear movement at the fracture site delays healing in a diaphyseal fracture model
    Peter Augat
    Department of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstr 14, 89081 Ulm, Germany
    J Orthop Res 21:1011-7. 2003
    ..05). In summary, fixation that allows excessive shear movement significantly delayed the healing of diaphyseal osteotomies compared to healing under axial movement of the same magnitude...
  73. ncbi Gene therapy to improve osteogenesis in bone lesions with severe soft tissue damage
    Tim Rose
    Department of Trauma and Reconstructive Surgery, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany
    Langenbecks Arch Surg 388:356-65. 2003
    ..The hypothesis for this study was that the cell-mediated gene therapy could improve the healing of bony lesions with severe soft tissue damage...
  74. ncbi Biomechanical evaluation of healing in a non-critical defect in a large animal model of osteoporosis
    C A Lill
    AO Research Institute Davos, Clavadelerstrasse, CH 7270, Davos, Switzerland
    J Orthop Res 21:836-42. 2003
    ..60) and to a lesser extent with callus density (r=0.53). This study demonstrated a delay of fracture healing in osteoporotic sheep tibiae with respect to callus formation, mineralization, and mechanical properties...
  75. ncbi Enhancing mechanical strength during early fracture healing via shockwave treatment: an animal study
    Robert Wen Wei Hsu
    Department of Orthopaedics, Chang Gung Memorial Hospital, Chang Gung Medical College, Chang Gung University, No 6, West Section, Chia Pu Road, Putz, Chia Yi, Taiwan, ROC
    Clin Biomech (Bristol, Avon) 18:S33-9. 2003
    ..This investigation aims to determine (1) whether shockwave treatment helps fracture healing and (2) whether the effect of shockwave treatment on fracture healing is dose dependent...
  76. ncbi The initial phase of fracture healing is specifically sensitive to mechanical conditions
    Petra Klein
    Trauma and Reconstructive Surgery, Charite, Campus Virchow Klinikum, Humboldt University of Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Orthop Res 21:662-9. 2003
    ..Therefore, initial mechanical stability of an osteosynthesis should be considered an important factor in clinical fracture treatment...
  77. ncbi The biomechanical environment of a bone fracture and its influence upon the morphology of healing
    Trevor Noel Gardner
    Oxford Orthopaedic Engineering Centre, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford, OX3 7LD, UK
    Med Eng Phys 25:455-64. 2003
    ..However, the hypothesis incorrectly predicted intramembraneous ossification during early healing of the main periosteal callus, although in later healing it correctly predicted endochondral ossification...
  78. ncbi Ultrasound stimulation of maxillofacial bone healing
    J Schortinghuis
    Department of Oral and Maxillofacial Surgery, University Hospital Groningen, PO Box 30 001, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Crit Rev Oral Biol Med 14:63-74. 2003
    ....
  79. ncbi [The preliminary result of osteoid callus allograft for bone healing]
    M Yan
    Department of Orthopedic Surgery, Third Teaching Hospital, Peking University, Beijing, P. R. China 100083
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 15:57-9. 2001
    ..It is inspiring to develop osteoid callus allograft as a kind of material for bone healing...
  80. ncbi In vivo axial dynamization of canine tibial fractures using the Securos external skeletal fixation system
    S C Gorman
    Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA 01536, USA
    Vet Comp Orthop Traumatol 18:199-207. 2005
    ..Dynamization at 31 days post-operatively may delay bone remodelling, despite a trend towards a larger callus size. The results of this study failed to show a definitive role for early full axial dynamization...
  81. ncbi Spontaneous bone regeneration in surgically induced bone defects in young rabbits
    Hae Ryong Song
    Department of Orthopaedic Surgery, School of Medicine, Gyeong Sang National University, Chinju, Korea
    J Pediatr Orthop B 11:343-9. 2002
    ..37) between two groups. The method of filling bone defect with callus generated from the intact periosteum may be a new therapeutic option for the reconstruction of large bone defects in children when other treatments are not available...
  82. ncbi Use of ultrasound to assess healing of a mandibular distraction wound
    Petra Thurmüller
    Massachusetts General Hospital, Harvard School of Dental Medicine and Harvard Medical School, Boston 02114, USA
    J Oral Maxillofac Surg 60:1038-44. 2002
    ..The purpose of this study was to test the feasibility of ultrasound to evaluate an experimental mandibular distraction osteogenesis wound...
  83. ncbi Insulin-like growth factor-1 and transforming growth factor-beta1 accelerates osteotomy healing using polylactide-coated implants as a delivery system: a biomechanical and histological study in minipigs
    M Raschke
    Department of Trauma and Reconstructive Surgery, Charite, Humboldt University of Berlin, Berlin, Germany
    Bone 30:144-51. 2002
    ..We conclude that local application of growth factors from a biodegradable PDLLA coating of intramedullary implants accelerates bone healing in a large animal model without systemic side effects...
  84. ncbi [New surgical treatment procedures in fractures of the distal tibia (LCP, MIPO)]
    C Ryf
    Spital Davos, Klinik für Chirurgie Orthopädie, Davos Platz
    Ther Umsch 60:768-75. 2003
    ..In the postoperative management of these injuries an unlimited cooperation between traumatologists and general practitioners is indispensable for a further successful course...
  85. ncbi Endochondral ossification in fracture callus during long bone repair: the localisation of 'cavity-lining cells' within the cartilage
    Joanna L Ford
    Division of Orthopaedic and Accident Surgery, C Floor, West Block, Queen s Medical Centre, University Hospital, Nottingham NG7 2UR, UK
    J Orthop Res 22:368-75. 2004
    ..It is thought that these cells play a role in the conversion of cartilage to bone during the fracture healing process...
  86. ncbi Neuromuscular electrical stimulation enhances fracture healing: results of an animal model
    Sang Hyun Park
    The J Vernon Luck Sr, MD, Orthopaedic Research Center, Orthopadeic Hospital UCLA, Los Angeles, CA 90007, USA
    J Orthop Res 22:382-7. 2004
    ..The results of the present study demonstrated that the use of NMES can enhance callus development and mineralization, with the consequent improvement in biomechanical properties of the healing bone...
  87. ncbi Repair of an intercalated long bone defect with a synthetic biodegradable bone-inducing implant
    Masahiro Yoneda
    Department of Orthopaedic Surgery, Osaka City University School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Biomaterials 26:5145-52. 2005
    ..These experimental results indicate that fully absorbable rhBMP-2/PLA-DX-PEG/beta-TCP is a promising composite having osteogenicity efficient enough for repairing large bone defects...
  88. ncbi Osteogenic gene regulation and relative acceleration of healing by adenoviral-mediated transfer of human BMP-2 or -6 in equine osteotomy and ostectomy models
    Akikazu Ishihara
    Comparative Orthopedic Research Laboratories, Department of Veterinary Clinical Sciences, The Ohio State University, 601 Tharp Street, Columbus, Ohio 43210, USA
    J Orthop Res 26:764-71. 2008
    ....
  89. pmc Pause insertions during cyclic in vivo loading affect bone healing
    Michael J Gardner
    Department of Orthopaedic Surgery, Harborview Medical Center, 325 9th Ave, Box 359798, Seattle, WA 98104, USA
    Clin Orthop Relat Res 466:1232-8. 2008
    ..At an early stage of fracture healing, pause-inserted loading led to more histologically advanced healing...
  90. pmc The effect of low-intensity pulsed ultrasound on callus maturation in tibial distraction osteogenesis
    Hani El-Mowafi
    Mansoura University Hospital, 35516 Mansoura, Egypt
    Int Orthop 29:121-4. 2005
    ..In group B, one patient failed to consolidate the regenerated bone. Low-intensity pulsed ultrasound stimulation is highly effective in achieving maturation of bone and reducing time of distraction osteogenesis...
  91. ncbi Expression of fibroblast growth factor receptor-3 (FGFR3), signal transducer and activator of transcription-1, and cyclin-dependent kinase inhibitor p21 during endochondral ossification: differential role of FGFR3 in skeletal development and fracture repa
    Arata Nakajima
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Endocrinology 144:4659-68. 2003
    ..These results indicate a differential role of FGFR3 in skeletal development and fracture repair...
  92. pmc Rapamycin affects early fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, Homburg Saar, Germany
    Br J Pharmacol 154:1055-62. 2008
    ....
  93. pmc Effect of age on vascularization during fracture repair
    Chuanyong Lu
    Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco, California 94143, USA
    J Orthop Res 26:1384-9. 2008
    ..Nonetheless, our results indicate that enhancing vascularization during fracture repair in the elderly may provide unique therapeutic opportunities...
  94. ncbi "Shear movement at the fracture site delays healing in a diaphyseal fracture model" by Peter Augat, Johannes Buger, Sandra Schorlemmer, Thomas Henke, Manfred Peraus, Lutz Claes [J Orthop Res 2003;21:1011-17]
    S H Park
    J Orthop Res 22:1156-7; author reply 1158-9. 2004
  95. ncbi [Biochemical control of callus maturation--an experimental animal study]
    J Schmidt
    Unfallchirurgie, Helios Klinikum Berlin Buch
    Z Orthop Unfall 146:490-7. 2008
    ..The purpose of this study was to verify the possibility of monitoring the callus maturation biochemically...
  96. ncbi [Relationship between tibia callus diameter ratio and prognosis during tibia lengthening]
    Ye Wu
    Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:174-6. 2004
    ..To investigate the relationship between the tibia callus diameter ratio (CDR) and prognosis during tibial distraction and the occurrence of late deformity or fracture...
  97. ncbi The influence of cyclic compression and distraction on the healing of experimental tibial fractures
    R Hente
    Department of Traumatology, Trauma Center Regensburg, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    J Orthop Res 22:709-15. 2004
    ..A higher number of enforced and maintained compressive displacements enhanced periosteal callus formation but did not allow bony bridging of the gap...
  98. ncbi Bacteriology of callus of closed fractures of tibia and femur
    Grzegorz Szczesny
    Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    J Trauma 65:837-42. 2008
    ..The question arises whether this clinical complication is not caused by bacteria dwelling in limb tissues...
  99. ncbi Differential bone turnover in an angulated fracture model in the rat
    J Li
    Department of Surgical Sciences, Section of Orthopedics, Karolinska Institutet, Stockholm, Sweden
    Calcif Tissue Int 75:50-9. 2004
    ..Our in-vivo model offers a means of analyzing morphologically and quantitatively the differential expression and action of factors involved in local bone turnover...
  100. ncbi Low-intensity pulsed ultrasound accelerates rat femoral fracture healing by acting on the various cellular reactions in the fracture callus
    Y Azuma
    Teijin Institute for Biomedical Research, Teijin Limited, Tokyo, Japan
    J Bone Miner Res 16:671-80. 2001
    ....
  101. ncbi Expression of bone matrix proteins mRNA during distraction osteogenesis
    M Sato
    Department of Orthopaedic Surgery, Osaka University Medical School, Suita, Japan
    J Bone Miner Res 13:1221-31. 1998
    ..As distraction advanced, the cartilaginous callus was progressively replaced by bony callus by endochondral ossification and thereafter new bone was formed directly by intramembranous ossification...

Research Grants11

  1. ROLE OF ANGIOGENESIS IN BONE REPAIR
    Theodore Miclau; Fiscal Year: 2004
    ..The Department of Orthopaedic Surgery and UCSF are fully committed to the support of junior faculty researchers. ..
  2. 2004 Annual Meeting: American Society of Biomechanics
    Michael Bottlang; Fiscal Year: 2004
    ..abstract_text> ..
  3. Prevention of Hip Dysplasia with Thermal Energy
    MANDI LOPEZ; Fiscal Year: 2005
    ..The University of Wisconsin provides an exceptional environment for interaction with experts in a variety of fields, and it is well known for its exceptional research programs, especially in the medical sciences. ..
  4. Inducing Skeletal Repair by Mechanical Stimulation
    Elise Morgan; Fiscal Year: 2009
    ..Taken together, these experiments represent the first steps in defining the mechano-regulated processes involved in the postnatal formation of functional hyaline cartilage. ..
  5. High-Resolution Desktop Micro-Computed Tomograpy System
    Elise Morgan; Fiscal Year: 2005
    ....
  6. Genes Controlling the Renal Handling of Phosphate
    Ralph Meyer; Fiscal Year: 2004
    ..Such intervention may improve the skeletal symptoms of patients with hypophosphatemic bone disease and improve their quality of life. ..
  7. An organotypic model of traumatic brain injury
    Michael Bottlang; Fiscal Year: 2004
    ..abstract_text> ..
  8. Tongue Volume, Function and Biomechanics
    Zi Jun Liu; Fiscal Year: 2006
    ..Application of this information will allow understanding of normal tongue functional morphology and to evaluate how tongue volume affects function and craniofacial growth. ..
  9. Evaluating and Improving and Emergent Technology for Fixation of Bone Fractures
    Michael Bottlang; Fiscal Year: 2007
    ..Furthermore, results may direct the future evolution of locked plate technology by providing a working solution to an inherent problem associated with contemporary locked plates. [unreadable] [unreadable] [unreadable]..
  10. Biology of stable and non-stable fracture repair
    Theodore Miclau; Fiscal Year: 2010
    ..Our goal is to use the findings from these studies to develop new treatments to stimulate fracture healing. ..
  11. MECHANISM FOR BONE SIALOPROTEIN TO NUCLEATE BIOAPATITE
    RONALD MIDURA; Fiscal Year: 2002
    ..abstract_text> ..