tibia

Summary

Summary: The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.

Top Publications

  1. ncbi Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:5866-75. 2008
  2. ncbi Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice
    Toshihiro Sugiyama
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Bone 43:238-48. 2008
  3. ncbi Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    Xiaodong Li
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California 91320 1799, USA
    J Bone Miner Res 24:578-88. 2009
  4. ncbi Transtibial versus anteromedial portal reaming in anterior cruciate ligament reconstruction: an anatomic and biomechanical evaluation of surgical technique
    Asheesh Bedi
    Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, New York 10021, USA
    Arthroscopy 27:380-90. 2011
  5. ncbi Anatomical analysis of the anterior cruciate ligament femoral and tibial footprints
    Harehiko Tsukada
    Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, 036 8562, Japan
    J Orthop Sci 13:122-9. 2008
  6. pmc The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, 1211 Geneva 14, Switzerland
    J Biol Chem 284:35939-50. 2009
  7. ncbi Independent drilling outperforms conventional transtibial drilling in anterior cruciate ligament reconstruction
    Mark E Steiner
    Sports Medicine Section, Orthopaedic Department, New England Baptist Hospital, Boston, Massachusetts 02120, USA
    Am J Sports Med 37:1912-9. 2009
  8. ncbi In vivo effects of modification of hydroxyapatite/collagen composites with and without chondroitin sulphate on bone remodeling in the sheep tibia
    Wolfgang Schneiders
    Department of Trauma and Reconstructive Surgery, University Hospital Carl Gustav Carus, Dresden, Germany
    J Orthop Res 27:15-21. 2009
  9. ncbi Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element
    Roberto L de Souza
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
    Bone 37:810-8. 2005
  10. ncbi Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
    Tadashi Hayami
    Department Molecular Endocrinology and Bone Biology, Merck Res Labs, West Point, PA 19486, USA
    Bone 38:234-43. 2006

Detail Information

Publications330 found, 100 shown here

  1. ncbi Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:5866-75. 2008
    ..Hindlimb unloading yielded a significant increase in Sost expression in the tibia. Modulation of sclerostin levels appears to be a finely tuned mechanism by which osteocytes coordinate regional ..
  2. ncbi Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice
    Toshihiro Sugiyama
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Bone 43:238-48. 2008
    ..in a dose- and time-dependent manner, which was particularly evident in the trabecular region of the proximal tibia. In the tibia, loading at a level sufficient by itself to stimulate osteogenesis produced an osteogenic response ..
  3. ncbi Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    Xiaodong Li
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California 91320 1799, USA
    J Bone Miner Res 24:578-88. 2009
    ....
  4. ncbi Transtibial versus anteromedial portal reaming in anterior cruciate ligament reconstruction: an anatomic and biomechanical evaluation of surgical technique
    Asheesh Bedi
    Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, New York 10021, USA
    Arthroscopy 27:380-90. 2011
    ..The purpose of this study was to objectively evaluate the anatomic and biomechanical outcomes of anterior cruciate ligament (ACL) reconstruction with transtibial versus anteromedial portal drilling of the femoral tunnel...
  5. ncbi Anatomical analysis of the anterior cruciate ligament femoral and tibial footprints
    Harehiko Tsukada
    Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, 036 8562, Japan
    J Orthop Sci 13:122-9. 2008
    ....
  6. pmc The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, 1211 Geneva 14, Switzerland
    J Biol Chem 284:35939-50. 2009
    ..the role of periostin in the skeletal response to moderate physical activity and direct axial compression of the tibia. Furthermore, we administered a sclerostin-blocking antibody to these mice in order to demonstrate the influence ..
  7. ncbi Independent drilling outperforms conventional transtibial drilling in anterior cruciate ligament reconstruction
    Mark E Steiner
    Sports Medicine Section, Orthopaedic Department, New England Baptist Hospital, Boston, Massachusetts 02120, USA
    Am J Sports Med 37:1912-9. 2009
    ..Optimal tunnel placement is critical in anterior cruciate ligament reconstructive surgery, yet the method used to drill the tunnels may compromise their placement...
  8. ncbi In vivo effects of modification of hydroxyapatite/collagen composites with and without chondroitin sulphate on bone remodeling in the sheep tibia
    Wolfgang Schneiders
    Department of Trauma and Reconstructive Surgery, University Hospital Carl Gustav Carus, Dresden, Germany
    J Orthop Res 27:15-21. 2009
    ..of adding CS to hydroxyapatite/collagen (HA/Col) composites on host response was assessed in a standard sheep tibia model. A midshaft defect of 3 cm was created in the tibiae of 14 adult female sheep...
  9. ncbi Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element
    Roberto L de Souza
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
    Bone 37:810-8. 2005
    ..This model for loading the tibia has several advantages over other approaches, including scope to study the effects of loading in cancellous as ..
  10. ncbi Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
    Tadashi Hayami
    Department Molecular Endocrinology and Bone Biology, Merck Res Labs, West Point, PA 19486, USA
    Bone 38:234-43. 2006
    ..Together, these findings support a role for bone remodeling in OA pathogenesis and suggest that these rat models are suitable for evaluating bone resorption inhibitors as potential disease-modifying pharmaco-therapies...
  11. ncbi Design, calibration and pre-clinical testing of an instrumented tibial tray
    Bernd Heinlein
    Biomechanics Laboratory, Department of Orthopaedics, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12203 Berlin, Germany
    J Biomech 40:S4-10. 2007
    ..The measured values will enhance the quality of future pre-clinical testing, numerical modeling in knee biomechanics and the patients' physiotherapy and rehabilitation...
  12. ncbi Recovery periods restore mechanosensitivity to dynamically loaded bone
    A G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    J Exp Biol 204:3389-99. 2001
    ..5, 3.5, 7 or 14 s), introduced between each of 36 identical daily loading cycles. Using the rat tibia four-point bending model, the right tibia of 144 adult female Sprague-Dawley rats was subjected to bending, sham ..
  13. ncbi Enhancement of the adolescent murine musculoskeletal system using low-level mechanical vibrations
    Liqin Xie
    Dept of Biomedical Engineering, Psychology A, 3rd Floor, State Univ of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    J Appl Physiol (1985) 104:1056-62. 2008
    ..Following 6 wk of WBV, bone mineralizing surfaces of trabeculae in the proximal metaphysis of the tibia were 75% greater (P < 0.05) than AC, while osteoclast activity was not significantly different...
  14. pmc Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    J Bone Miner Res 25:983-93. 2010
    ..applied to high-resolution peripheral quantitative computed tomography (HR-pQCT) images of the distal radius and tibia. The distal radius and tibia of 151 subjects (57 male, 94 female; 47 +/- 16 years of age, range 20 to 78 years) ..
  15. ncbi A trabecular metal tibial component in total knee replacement in patients younger than 60 years: a two-year radiostereophotogrammetric analysis
    A Henricson
    Umea University Hospital, Umea, Sweden
    J Bone Joint Surg Br 90:1585-93. 2008
    ..This pattern of subsidence is regarded as being beneficial for uncemented fixation...
  16. pmc The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading
    Alaa Moustafa
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, London, UK
    Bone 44:930-5. 2009
    Bones' functionally adaptive responses to mechanical loading can usefully be studied in the tibia by the application of loads between the knee and ankle in normal and genetically modified mice. Such loading also deforms the fibula...
  17. ncbi Anterior cruciate ligament reconstruction: can anatomic femoral placement be achieved with a transtibial technique?
    Dana P Piasecki
    OrthoCarolina, Sports and Complex Knee Center, Charlotte, NC 28207, USA
    Am J Sports Med 39:1306-15. 2011
    ..Recent reports have suggested that a traditional transtibial technique cannot practically accomplish an anatomic anterior cruciate ligament (ACL) reconstruction...
  18. ncbi Cross-sectional geometry of weight-bearing tibia in female athletes subjected to different exercise loadings
    R Nikander
    Bone Research Group, UKK Institute for Health Promotion Research, Kaupinpuistonkatu 1, 33501, Tampere, Finland
    Osteoporos Int 21:1687-94. 2010
    The association of long-term sport-specific exercise loading with cross-sectional geometry of the weight-bearing tibia was evaluated among 204 female athletes representing five different exercise loadings and 50 referents...
  19. ncbi The effect of valgus braces on medial compartment load of the knee joint - in vivo load measurements in three subjects
    Ines Kutzner
    Julius Wolff Institute, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Biomech 44:1354-60. 2011
    ..Valgus adjustments of 8° might, especially with the MOS brace, not be tolerated by patients for a long time. Medial load reductions of more than 25% can therefore probably not be expected in clinical practise...
  20. pmc Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
    Bone 47:519-28. 2010
    ..directly quantify cortical density, geometry, and microarchitecture from HR-pQCT images of the distal radius and tibia. An automated segmentation technique was developed to identify the periosteal and endosteal margins of the distal ..
  21. ncbi Differences of three-dimensional trabecular microstructure in osteopenic rat models caused by ovariectomy and neurectomy
    M Ito
    Department of Radiology, Nagasaki University School of Medicine, Nagasaki, Japan
    Bone 30:594-8. 2002
    ..whereas the ovx rats exhibited a diffuse disappearance of trabeculae, especially in the central part of the tibia, but with a preservation of shape for those trabeculae that were retained...
  22. ncbi Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis--a preliminary result of three cases
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Bone 35:892-8. 2004
    ..and two tibiae of the two patients with achondroplasia and one patient with congenital pseudarthrosis of the tibia. MSCs derived from the iliac crest were cultured with osteogenic supplements and differentiated into osteoblast-..
  23. ncbi Effect of human parathyroid hormone hPTH (1-34) applied at different regimes on fracture healing and muscle in ovariectomized and healthy rats
    Marina Komrakova
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch 40, 37075 Goettingen, Germany
    Bone 47:480-92. 2010
    ..Five-month old rats underwent bilateral transverse metaphyseal osteotomy of tibia and were divided into groups (12 rats each)...
  24. ncbi Anterior cruciate ligament tunnel position measurement reliability on 3-dimensional reconstructed computed tomography
    Pisit Lertwanich
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Arthroscopy 27:391-8. 2011
    ..The purpose of this study was to evaluate intraobserver and interobserver reliability of anterior cruciate ligament tunnel location measurement by use of 3-dimensional reconstructed computed tomography (CT)...
  25. pmc Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle
    Sundar Srinivasan
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle 98104 2499, USA
    J Bone Miner Res 17:1613-20. 2002
    ..9 +/- 4.5%; p = 0.03). In the murine tibia model, 5 consecutive days of 100 low-magnitude loading cycles did not significantly alter mean periosteal bone ..
  26. ncbi A finite element model of the human knee joint for the study of tibio-femoral contact
    Tammy L Haut Donahue
    Department of Mechanical Engineering, Michigan Technological University, Houghton 49931, USA
    J Biomech Eng 124:273-80. 2002
    ..The model included both the cortical and trabecular bone of the femur and tibia, articular cartilage of the femoral condyles and tibial plateau, both the medial and lateral menisci with their ..
  27. ncbi Evaluation of bone plate with low-stiffness material in terms of stress distribution
    Semih Benli
    Faculty of Engineering, Dokuz Eylul University, 35100 Bornova, Izmir, Turkey
    J Biomech 41:3229-35. 2008
    ..Compressive stresses occurring in the intact portion of the bone (tibia) and at the fractured interface at different stages of bone healing have been investigated for all three types of ..
  28. ncbi Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma
    Philipp Niemeyer
    Department of Orthopedic Surgery and Traumatology, Freiburg University Hospital, Freiburg, Germany
    Biomaterials 31:3572-9. 2010
    ..ASC (ASC-group) were seeded on mineralized collagen sponges and implanted into a critical size defect of the sheep tibia (n=5 each). In an additional group, platelet-rich plasma (PRP) was used in combination with ASC (PRP-group)...
  29. pmc Effects of PTH treatment on tibial bone of ovariectomized rats assessed by in vivo micro-CT
    J E M Brouwers
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Osteoporos Int 20:1823-35. 2009
    ..Bone was formed in cavities, leading to restoral of nearly cleaved trabeculae. For the first time, effects in PTH-treated rats were analyzed longitudinally...
  30. pmc Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
    O Vidal
    Department of Internal Medicine, Division of Endocrinology, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    Proc Natl Acad Sci U S A 97:5474-9. 2000
    ..Therefore, ERalpha, but not ERbeta, mediates important effects of estrogen in the skeleton of male mice during growth and maturation...
  31. pmc Allograft-prosthetic composite in the proximal tibia after bone tumor resection
    Davide Donati
    Musculoskeletal Oncology Department, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40126 Bologna, Italy
    Clin Orthop Relat Res 466:459-65. 2008
    We consider an allograft-prosthesis composite in the proximal tibia one of the better reconstructive options in this site because it combines the mechanical stability of a prosthesis with the biologic reconstruction of the extensor ..
  32. ncbi Estrogen receptors α and β have different gender-dependent effects on the adaptive responses to load bearing in cancellous and cortical bone
    L K Saxon
    The Royal Veterinary College, Royal College Street London, London NW1 OTU, United Kingdom
    Endocrinology 153:2254-66. 2012
    ..Bone loss due to disuse in cortical bone is unaffected by ER status, but in cancellous bone, functional ERα contributes to greater disuse-related bone loss...
  33. ncbi Different patterns of bone fixation with hydroxyapatite and resorbable CaP coatings in the rabbit tibia at 6, 12, and 52 weeks
    Ole Reigstad
    Orthopaedic Department, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    J Biomed Mater Res B Appl Biomater 99:14-20. 2011
    ..HA) coating, applied on grit-blasted screw-shaped Ti-6Al-4V implants in the cortical region of rabbit tibia, implanted for 6, 12, and 52 weeks...
  34. ncbi Tibio-femoral movement in the living knee. A study of weight bearing and non-weight bearing knee kinematics using 'interventional' MRI
    P Johal
    Department of Orthopaedics, St Mary s Hospital, W2 1NY London, UK
    J Biomech 38:269-76. 2005
    ..flexion in tibial external rotation, the lateral femoral condyle adopts a more anterior position relative to the tibia and, particularly in the non-weight bearing knee, much of the femoral external rotation that occurs with flexion ..
  35. pmc Surgical treatment of grade I central chondrosarcoma
    Davide Donati
    Musculoskeletal Oncology Department, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40136, Bologna, Italy
    Clin Orthop Relat Res 468:581-9. 2010
    ....
  36. ncbi The effect of ankle rotation on cutting of the tibia in total knee arthroplasty
    Hideki Mizu-uchi
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka City, 812 8582, Japan
    J Bone Joint Surg Am 88:2632-6. 2006
    Extramedullary alignment guides are commonly used to prepare the tibia during total knee arthroplasty. One disadvantage is that the guide is easily affected by the position of the ankle joint...
  37. pmc Quantitative characterization of subject motion in HR-pQCT images of the distal radius and tibia
    Miki Sode
    Joint Graduate Group in Bioengineering, University of California at San Francisco and Berkeley, San Francisco and Berkeley, CA, USA
    Bone 48:1291-7. 2011
    ..A total of 88 HR-pQCT exams with repeated acquisitions of the distal radius (N = 54) or distal tibia (N = 34) of 49 women (age = 59 ± 14 year) and 3 men (46 ± 2 year) were retrospectively evaluated...
  38. pmc Bone tissue response to porous and functionalized titanium and silica based coatings
    Amol Chaudhari
    Department of Prosthetic Dentistry, BIOMAT Research Group, K U Leuven, Leuven, Belgium
    PLoS ONE 6:e24186. 2011
    ..Topography and presence of bio-mimetic coatings are known to improve osseointegration. The objective of this study was to evaluate the bone regeneration potential of porous and osteogenic coatings...
  39. pmc Cancellous bone adaptation to tibial compression is not sex dependent in growing mice
    Maureen E Lynch
    Mechanical and Aerospace Engineering, Cornell University, 219 Upson Hall, Ithaca, NY 14853, USA
    J Appl Physiol (1985) 109:685-91. 2010
    ..Ten-week-old male and female C57Bl/6 mice underwent noninvasive compression of the left tibia. Peak loads of -11.5 N were applied, corresponding to +1,200 microepsilon at the tibial midshaft in both sexes...
  40. ncbi The effect of distraction-resisting forces on the tibia during distraction osteogenesis
    Ashok K Shyam
    Department of Orthopedic Surgery, Rare Disease Institute, Korea University, Guro Hospital, Guro Gu, Seoul 152 703, South Korea
    J Bone Joint Surg Am 91:1671-82. 2009
    ..We investigated the nature of distraction-resisting forces by studying their correlation with these parameters...
  41. ncbi The influence of muscle load on tibiofemoral knee kinematics
    Jan Victor
    Department of Orthopaedics, AZ St Lucas, St Lucaslaan 29, 8310 Brugge, Belgium
    J Orthop Res 28:419-28. 2010
    ..of the projected centers of the medial (MFT) and lateral femoral condyles (LFT) in the horizontal plane of the tibia, and tibial axial rotation (TR) as a function of flexion angle...
  42. pmc Dosimetry during intramedullary nailing of the tibia
    George Kirousis
    Department of Orthopaedics, School of Medicine, University of Patras, Patras, Greece
    Acta Orthop 80:568-72. 2009
    ..Intramedullary nailing under fluoroscopic guidance is a common operation. We studied the intraoperative radiation dose received by both the patient and the personnel...
  43. ncbi High tibial valgus osteotomy in unicompartmental medial osteoarthritis of the knee: a retrospective follow-up study over 13-21 years
    Alex Schallberger
    Department of Orthopaedic Surgery, Hopital Cantonal Fribourg, 1708 Fribourg, Switzerland
    Knee Surg Sports Traumatol Arthrosc 19:122-7. 2011
    ..High tibial osteotomy is a well-established method for the treatment of medial unicompartmental osteoarthritis of the knee...
  44. ncbi Expression of matrix metalloproteinases during impairment and recovery of the avian growth plate
    H Dan
    Department of Biochemistry and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, Hebrew University, Israel
    J Anim Sci 87:3544-55. 2009
    ..Our results strengthen the link between MMP expression and growth-plate impairment, and we suggest that gelatinase activity (MMP-2 and 9) facilitates this process...
  45. pmc Local bisphosphonate treatment increases fixation of hydroxyapatite-coated implants inserted with bone compaction
    Thomas Jakobsen
    Orthopaedic Research Laboratory, Department of Orthopaedics, Aarhus University Hospital, Aarhus C, Denmark
    J Orthop Res 27:189-94. 2009
    ..This study indicates that local alendronate treatment can further improve the fixation of porous-coated implants that have also undergone HA-surface coating and peri-implant bone compaction...
  46. pmc AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass
    M Shah
    Department of Veterinary Basic Sciences Royal Veterinary College, Royal College Street, London, NW1 OTU, UK
    Bone 47:309-19. 2010
    ..RT-PCR analysis of AMPK subunits in ROS17/2.8 osteoblastic cells and in mouse tibia showed that the AMPKalpha1 subunit is the dominant isoform expressed in bone...
  47. ncbi Validation of a new technique to determine midbundle femoral tunnel position in anterior cruciate ligament reconstruction using 3-dimensional computed tomography analysis
    Jonathan H Bird
    Department of Trauma and Orthopaedic Surgery, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, England
    Arthroscopy 27:1259-67. 2011
    ..The purpose of this study was to investigate and report on a new intraoperative measuring technique to place the anterior cruciate ligament (ACL) femoral tunnel in the center of the native ACL femoral insertion site...
  48. ncbi Femoral bone tunnel placement using the transtibial tunnel or the anteromedial portal in ACL reconstruction: a radiographic evaluation
    Jens Dargel
    Institute II for Anatomy, University of Cologne, Joseph Stelzmann Strasse 9, Cologne 50931, Germany
    Knee Surg Sports Traumatol Arthrosc 17:220-7. 2009
    ..Further studies may evaluate if there are any clinical advantages using the anteromedial portal technique...
  49. ncbi Melatonin stimulates the growth of new bone around implants in the tibia of rabbits
    José L Calvo-Guirado
    Department of General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain
    J Pineal Res 49:356-63. 2010
    ..with melatonin and 20 control implants without melatonin were placed in the proximal metaphyseal area of each tibia. Studies of new bone formation were subsequently made at 15, 30, 45 and 60 days...
  50. ncbi Computer-assisted knee arthroplasty versus a conventional jig-based technique. A randomised, prospective trial
    S K Chauhan
    Royal Perth Hospital, Perth, Western Australia
    J Bone Joint Surg Br 86:372-7. 2004
    ..011) and femorotibial mismatch (p = 0.037). Standing alignment was also improved (p = 0.004) and blood loss was less (p = 0.0001). Computer-assisted surgery took longer with a mean increase of 13 minutes (p = 0.0001)...
  51. ncbi Early bone tissue responses to turned and oxidized implants in the rabbit tibia
    Patricia Miranda Burgos
    Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Clin Implant Dent Relat Res 10:181-90. 2008
    ..The mechanisms leading to a stronger bone response to oxidized titanium are not well understood...
  52. pmc Bone mass and strength in older men with type 2 diabetes: the Osteoporotic Fractures in Men Study
    Moira A Petit
    School of Kinesiology, Laboratory for Musculoskeletal Health, University of Minnesota, Minneapolis, MN, USA
    J Bone Miner Res 25:285-91. 2010
    ..At both the distal tibia and radius, patients with T2DM had greater bone vBMD (+2% to +4%, model 1, p < ...
  53. ncbi Bone microstructure at the distal tibia provides a strength advantage to males in late puberty: an HR-pQCT study
    Melonie Burrows
    Department of Orthopaedics, Centre for Hip Health and Mobility, University of British Columbia, British Columbia, Canada
    J Bone Miner Res 25:1423-32. 2010
    ..Sp), trabecular spacing standard deviation (Tb.Sp SD), and bone strength index (BSI, mg2/mm4) at the distal tibia in 133 females and 146 males (15 to 20 years of age)...
  54. ncbi Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in men
    Nicolas Vilayphiou
    INSERM Research Unit 831 and Université de Lyon, Lyon, France
    J Bone Miner Res 26:965-73. 2011
    ..by high resolution (HR)-pQCT, and finite element (µFE) analysis was based on HR-pQCT images of distal radius and tibia. A principal component (PC) analysis (PCA) was used to study the association of synthetic PCs with fracture by ..
  55. ncbi Effects of increasing tibial slope on the biomechanics of the knee
    J Robert Giffin
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Sports Med 32:376-82. 2004
    ..To determine the effects of increasing anterior-posterior (A-P) tibial slope on knee kinematics and in situ forces in the cruciate ligaments...
  56. ncbi Treatment of anterior cruciate ligament injuries with special reference to graft type and surgical technique: an assessment of randomized controlled trials
    Kristian Samuelsson
    Department of Orthopaedics, Sahlgrenska University Hospital, SE 431 80, Molndal, Sweden
    Arthroscopy 25:1139-74. 2009
    ..The secondary aims were to identify the relative strengths and weaknesses of the selected studies, to resolve contradictions in the literature, and to evaluate the need for further studies...
  57. ncbi Importance of tibial slope for stability of the posterior cruciate ligament deficient knee
    J Robert Giffin
    Department of Orthopaedic Surgery, University of Western Ontario, London, Ontario, Canada
    Am J Sports Med 35:1443-9. 2007
    Previous studies have shown that increasing tibial slope can shift the resting position of the tibia anteriorly...
  58. pmc Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture
    Isao Kii
    Department of Biological Information, Tokyo Institute of Technology, 4259 Midori ku, Nagatsuta, Yokohama 226 8501
    J Biol Chem 285:2028-39. 2010
    ..This study suggests a role for periostin in adaptation of the ECM architecture in the mechanical environment...
  59. ncbi The long-term outcome of high tibial osteotomy: a ten- to 20-year follow-up
    S Akizuki
    Department of Orthopaedic Surgery, Nagano Matsushiro General Hospital, 183 Matsushiro, Nagano City 381 1231, Japan
    J Bone Joint Surg Br 90:592-6. 2008
    ..5 kg/m(2) and range of movement < 100 degrees were risk factors predicting early failure. Although our long-term results were satisfactory, strict indications for osteotomy are required if long-term survival is required...
  60. ncbi Bone lead levels and blood pressure endpoints: a meta-analysis
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Epidemiology 19:496-504. 2008
    ..We performed a meta-analysis of the association of bone lead levels with systolic blood pressure, diastolic blood pressure, and hypertension using published data...
  61. ncbi Bone mass and structure in adolescents with type 1 diabetes compared to healthy peers
    M T Saha
    Department of Paediatrics, Tampere University Hospital, 33521 Tampere, Finland
    Osteoporos Int 20:1401-6. 2009
    ..Our results showed that diabetes is associated with reduced bone mass and smaller bones. The diabetes-associated deficits seemed to concern male adolescents more than females...
  62. pmc The geometry of the tibial plateau and its influence on the biomechanics of the tibiofemoral joint
    Javad Hashemi
    Department of Mechanical Engineering, Texas Tech University, 7th and Boston Streets, Lubbock, TX 79409 1021, USA
    J Bone Joint Surg Am 90:2724-34. 2008
    ....
  63. ncbi The role of sensory signals from the insect coxa-trochanteral joint in controlling motor activity of the femur-tibia joint
    T Akay
    Zoologisches Institut, , 50923 Cologne, Germany
    J Neurophysiol 85:594-604. 2001
    ..that sensory signals from the coxa-trochanteral (CT) joint play in patterning motoneuronal activity of the femur-tibia (FT) joint in the stick insect middle leg...
  64. pmc Habitual levels of physical activity influence bone mass in 11-year-old children from the United Kingdom: findings from a large population-based cohort
    Jon H Tobias
    University of Bristol, UK
    J Bone Miner Res 22:101-9. 2007
    ..Physical activity was positively related to both BMD and bone size in fully adjusted models. However, further exploration revealed that this effect on bone size was modified by fat mass...
  65. pmc Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered
    A Moustafa
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, London, UK
    Osteoporos Int 23:1225-34. 2012
    ..Osteocyte sclerostin is regulated by loading and disuse in mouse tibiae but is more closely related to subsequent local osteogenesis than the peak strains engendered...
  66. ncbi Primary stability of various implants in tibial opening wedge osteotomy: a biomechanical study
    Gunter Spahn
    Clinic of Traumatology, Sophienstrasse 16, D 99817 Eisenach, Germany
    J Orthop Sci 7:683-7. 2002
    ..5 degrees, 10 degrees, 12.5 degrees, 15 degrees ) on axial stress resistance ( Fmax 2548, 2090, 1975, and 1740, respectively) was evaluated, and a direct correlation was found ( R = 0.794, P < 0.05)...
  67. ncbi Autoclaved tumor bone for reconstruction: an alternative in developing countries
    Mujahid Jamil Khattak
    Aga Khan University Hospital, Orthopedic Section, Department of Surgery, Karachi, Pakistan
    Clin Orthop Relat Res 447:138-44. 2006
    ..This technique is a cost-effective alternative for developing countries circumventing complications of prosthetic and allograft reconstruction...
  68. ncbi High-impact exercise and growing bone: relation between high strain rates and enhanced bone formation
    S Judex
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Alberta, Canada
    J Appl Physiol (1985) 88:2183-91. 2000
    ..Comparing the mechanical milieus produced by running and drop jumps revealed that jumping significantly elevated only peak strain rates. This further emphasized the sensitivity of immature bone to high strain rates...
  69. pmc PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures
    Carmen Huesa
    The Roslin Institute and Royal School of Veterinary Studies, University of Edinburgh, Edinburgh, UK
    Bone 48:1066-74. 2011
    ..nanoindentation the elastic modulus and hardness of Phospho1(-/-) tibiae were significantly lower than wild-type tibia. Raman microscopy revealed significantly lower mineral:matrix ratios and lower carbonate substitutions in Phospho1(..
  70. ncbi Influence of nonenzymatic glycation on biomechanical properties of cortical bone
    D Vashishth
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180
    Bone 28:195-201. 2001
    ....
  71. pmc Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption
    H Yoshitake
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3 10 Kanda Surugadai 2 Chome, Chiyoda ku, Tokyo, Japan
    Proc Natl Acad Sci U S A 96:8156-60. 1999
    ..We propose that osteopontin is essential for postmenopausal osteoporosis in women. Strategies to counteract osteopontin's action may prove effective in suppressing osteoporosis...
  72. ncbi Tibial forces measured in vivo after total knee arthroplasty
    DARRYL D D'LIMA
    Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, California, USA
    J Arthroplasty 21:255-62. 2006
    ..Technical design improvements will enhance function, quality of life, and longevity of total knee arthroplasty...
  73. ncbi High tibial osteotomy for medial compartment osteoarthritis
    G S E Dowd
    Department of Orthopaedics, Royal Free Hospital, Pond Street, London NW3 2QG, UK
    Knee 13:87-92. 2006
    ..An attempt has been made to incorporate important technical considerations, recent developments and other treatment options in this condition...
  74. ncbi Shallow medial tibial plateau and steep medial and lateral tibial slopes: new risk factors for anterior cruciate ligament injuries
    Javad Hashemi
    Department of Mechanical Engineering, Texas Tech University, 7th and Boston Streets, Lubbock, TX 79409 1021, USA
    Am J Sports Med 38:54-62. 2010
    ....
  75. ncbi Treatment of congenital pseudarthrosis of the tibia: a multicenter study in Japan
    Isao Ohnishi
    Department of Pediatric Orthopaedics, Shizuoka Children s Hospital, Shizuoka, Japan
    J Pediatr Orthop 25:219-24. 2005
    Treatment of congenital pseudarthrosis of the tibia (CPT) remains a challenge. To clarify the current situation in treatment, a multicenter study was carried out to obtain information on the results of CPT treatment...
  76. pmc Longitudinal live animal micro-CT allows for quantitative analysis of tumor-induced bone destruction
    Lindsay C Johnson
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
    Bone 48:141-51. 2011
    ..utilized the MDA-MB-231 osteolytic breast cancer model in which the tumor cells are inoculated directly into the tibia of athymic nude mice and imaged mice weekly by Faxitron (radiography), Imtek μCT (in vivo), and Maestro (GFP-..
  77. ncbi Bone micro-architecture and determinants of strength in the radius and tibia: age-related changes in a population-based study of normal adults measured with high-resolution pQCT
    N Dalzell
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge, CB1 8RN, UK
    Osteoporos Int 20:1683-94. 2009
    ..Important effects of ageing and contrasts in the effects of sex on the micro-architecture and strength of upper and lower limb bones were revealed...
  78. ncbi The effect of closed wedge high tibial osteotomy on tibial slope: a radiographic study
    Erik Hohmann
    Musculoskeletal Research Unit, Central Queensland University, P O Box 4045, Rockhampton, QLD 4700, Australia
    Knee Surg Sports Traumatol Arthrosc 14:454-9. 2006
    ..0001) decrease of the posterior tibial slope to a mean of 1.2 degrees . The magnitude of HTO in the frontal plane had no significant effect (P=0.739) on the postsurgical posterior tibial slope in the sagittal plane...
  79. ncbi The effects of rotation on radiographic evaluation of the tibiofibular syndesmosis
    Spiros G Pneumaticos
    Department of Orthopaedic Surgery, Baylor College of Medicine, Houston, TX, USA
    Foot Ankle Int 23:107-11. 2002
    ..The tibiofibular clear space, the tibiofibular overlap, the width of the tibia and fibula, and the medial clear space were measured on each film...
  80. ncbi Thrust during ambulation and the progression of knee osteoarthritis
    Alison Chang
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 50:3897-903. 2004
    ....
  81. ncbi Morphology of anterior cruciate ligament attachments for anatomic reconstruction: a cadaveric dissection and radiographic study
    Philippe Colombet
    Department d Anatomie, Universite de Tours
    Arthroscopy 22:984-92. 2006
    ..To define the positions of the attachments of the anteromedial (AM) and posterolateral (PL) bundles of the anterior cruciate ligament (ACL)...
  82. pmc Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice
    S H Windahl
    Department of Biosciences, Karolinska Institute, Novum, S 14157 Huddinge, Sweden
    J Clin Invest 104:895-901. 1999
    ..In summary, ERbeta is essential for the pubertal feminization of the cortical bone in female mice but is not required for the protective effect of estrogens on trabecular BMD...
  83. ncbi Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study
    Kyle K Nishiyama
    Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Canada
    J Bone Miner Res 25:882-90. 2010
    ..The analysis was applied to distal radius and tibia HR-pQCT scans from a subset of participants from the Calgary, Alberta, cohort of the Canadian Multicentre ..
  84. ncbi How precise can bony landmarks be determined on a CT scan of the knee?
    J Victor
    AZ St Lucas, Brugge, Belgium
    Knee 16:358-65. 2009
    ..78 degrees) and for the transverse axis (respectively 1.89 degrees and 2.03) on the tibia. This study demonstrates low intra- and inter-observer variability in the CT registration of landmarks that define ..
  85. ncbi Low-level accelerations applied in the absence of weight bearing can enhance trabecular bone formation
    Russell Garman
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    J Orthop Res 25:732-40. 2007
    ..of the murine skeleton without the direct application of deformations to the tissue, was used to subject the left tibia of eight anesthesized adult female C57BL/6J mice to small (0.3 g or 0...
  86. ncbi Local alendronate increases fixation of implants inserted with bone compaction: 12-week canine study
    Thomas Jakobsen
    Orthopaedic Research Laboratory, Department of Orthopaedics, Aarhus University Hospital, Norrebrogade 44, Bldg 1A, DK 8000 Aarhus C, Denmark
    J Orthop Res 25:432-41. 2007
    ..Porous-coated titanium implants were bilaterally inserted with bone compaction into the proximal part of tibia of 10 dogs...
  87. ncbi Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeleton
    Liqin Xie
    Department of Biomedical Engineering, Psychology A, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Bone 39:1059-66. 2006
    ..signal induced strain oscillations of approximately 10 microstrain on the periosteal surface of the proximal tibia. After 3 weeks of WBV, applied for 15 min each day, osteoclastic activity in the trabecular metaphysis and ..
  88. ncbi The relationship between the angle of the tibial tunnel in the coronal plane and loss of flexion and anterior laxity after anterior cruciate ligament reconstruction
    S M Howell
    Department of Mechanical and Aeronautical Engineering, University of California at Davis, USA
    Am J Sports Med 29:567-74. 2001
    ..angle of the tibial tunnel in the coronal plane is vertical or more perpendicular to the medial joint line of the tibia; however, the relationship of the angle of the tibial tunnel to knee function has not been studied...
  89. ncbi Alignments and clinical results in conventional and navigated total knee arthroplasty
    A Ensini
    Department of Orthopaedic Surgery, University of Bologna, Italy
    Clin Orthop Relat Res 457:156-62. 2007
    ..However, clinical scoring systems showed this radiographic improvement did not necessarily result in a better clinical outcome at short-term followup...
  90. ncbi Tibio-femoral loading during human gait and stair climbing
    William R Taylor
    Research Laboratory, Trauma and Reconstructive Surgery, Charite, Humboldt University of Berlin, Campus Virchow Clinic, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Orthop Res 22:625-32. 2004
    ..Clinically, the conditions that produce these larger contact forces should be avoided during post-operative rehabilitation...
  91. ncbi Anatomy of the tibiofibular syndesmosis and its clinical relevance
    Jan Bartonicek
    Orthopedic Department of 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    Surg Radiol Anat 25:379-86. 2003
    ..Direct contact between the distal tibia and the fibula was found in 23 cases...
  92. ncbi Perinatal testosterone surge is required for normal adult bone size but not for normal bone remodeling
    Natalie A Sims
    Department of Medicine at St Vincent s Hospital, the University of Melbourne and St Vincent s Institute, Fitzroy, Victoria, Australia
    Am J Physiol Endocrinol Metab 290:E456-62. 2006
    ..These data suggest a role for the perinatal T surge in determining adult bone length and confirms that adult circulating T determines adult bone density...
  93. ncbi A comparison of 2 drilling techniques on the femoral tunnel for anterior cruciate ligament reconstruction
    Chealon D Miller
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    Arthroscopy 27:372-9. 2011
    ..This cadaveric study was undertaken to characterize the femoral tunnel geometry resulting from commonly used drilling techniques in anterior cruciate ligament reconstruction...
  94. ncbi Lessons learned from the last 20 years of ACL-related in vivo-biomechanics research of the knee joint
    Evangelos Pappas
    Division of Physical Therapy, Long Island University Brooklyn Campus, Brooklyn, NY 11201, USA
    Knee Surg Sports Traumatol Arthrosc 21:755-66. 2013
    ..The purpose of this review is to summarize the evidence from biomechanical studies on ACL-related research...
  95. ncbi Anti-infection tissue engineering construct treating osteomyelitis in rabbit tibia
    Junchao Xing
    Department of Orthopaedics, Southwest Hospital, Chongqing, China
    Tissue Eng Part A 19:255-63. 2013
    ..alginate beads (Vanco-AB) to form composites, in the treatment of chronic osteomyelitis with bone defect in rabbit tibia. The infected bone defect model of rabbit tibia was established...
  96. pmc Muscle power and physical activity are associated with bone strength in older men: The osteoporotic fractures in men study
    Julie M Cousins
    School of Kinesiology, Laboratory for Musculoskeletal Health, University of Minnesota, Minneapolis, MN 55455, USA
    Bone 47:205-11. 2010
    ..of these analyses was to explore whether physical activity score, leg power or grip strength were associated with tibia and radius estimates of bone strength, cortical density, or total bone area...
  97. pmc Musculoskeletal response to whole-body vibration during fracture healing in intact and ovariectomized rats
    Ewa K Stuermer
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch St 40, 37075 Goettingen, Germany
    Calcif Tissue Int 87:168-80. 2010
    ..3 months of age) and 30 intact 5-month old female Sprague-Dawley rats underwent bilateral metaphyseal osteotomy of tibia. Five days later, half of the ovariectomized and of the intact rats were exposed to whole-body vertical vibration (..
  98. ncbi The patellar tendon bar! Is it a necessary feature?
    N A Abu Osman
    Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Med Eng Phys 32:760-5. 2010
    ....
  99. ncbi Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts
    L Vico
    Laboratoire de Biologie et Biochimie du Tissu Osseaux, INSERM E9901, GIP Exercice, Faculté de Médecine de St Etienne, France
    Lancet 355:1607-11. 2000
    ..Microgravity has been thought to induce osteoporosis because of reduced weight-bearing. However, up to now, few data have been available about its precise nature and timecourse...
  100. ncbi Effects of hydrosyapatite coating on Ti-6A1-4V implant-site infection in a rabbit tibial model
    H C Vogely
    Department of Orthopaedics, University Medical Center Utrecht, The Netherlands
    J Orthop Res 18:485-93. 2000
    ..Prior to implantation, the left tibia was contaminated with increasing concentrations of Staphylococcus aureus (10(2)-10(5) colony-forming units), ..
  101. ncbi Mechanical evaluation of large-size fourth-generation composite femur and tibia models
    Matthew P Gardner
    Department of Surgery, Section of Orthopaedics, The University of Kansas School of Medicine Wichita, 929 N St Francis, Wichita, KS 67214, USA
    Ann Biomed Eng 38:613-20. 2010
    ..to evaluate the diaphyseal structural properties of the large-size Fourth-Generation composite analogue femur and tibia models concentrated on mechanical behaviors under axial compression, bending and torsion...

Research Grants65

  1. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010
    ..Those occurring in the distal tibia, for instance, frequently require multiple procedures to achieve union...
  2. VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..2: High-dose vitamin D3 will improve: vBMD and bone structure and architecture at the distal radius and tibia, as assessed by HR-pQCT and bone strength estimates;Aim 3: High-dose vitamin D3 will result in lower (a) total ..
  3. Foot Bone Motion in End Stage Ankle Arthritis Patients
    William R Ledoux; Fiscal Year: 2012
    ..while it is known that both treatments for ESAA are susceptible to misalignments of the talus relative to the tibia, the specific effects f poor alignment on the distal joints are not well understood...
  4. Inflammasome Activation in Complex Regional Pain Syndrome
    Wade S Kingery; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Complex Regional Pain Syndrome Type I (CRPS I) is a frequent sequela of distal tibia and radius fractures and limb surgery though it can occur even after minor injuries...
  5. Effect of botulinum toxin plus vibration on bone in children with cerebral palsy
    Christopher M Modlesky; Fiscal Year: 2012
    ..of bone mineral content (BMC) and the development of trabecular and cortical bone structure in the femur and tibia through alterations in bone turnover and that the Botox-induced deterioration of bone can be mitigated by a daily ..
  6. Bone Microarchitecture: The Framingham Osteoporosis Study
    Douglas P Kiel; Fiscal Year: 2013
    ..We will measure volumetric BMD, bone microarchitecture and bone strength at the distal radius and distal tibia using three-dimensional HR-pQCT in 1,411 women and 1,154 men in the Framingham Offspring Cohort...
  7. Effect of Intense Multi-Modal Training on Bone Mineral Density, Bone Biomarkers,
    Todd Anthony Astorino; Fiscal Year: 2013
    ..Bone loss is rapid in the initial six months post-injury and is greatest in sites such as the tibia and femur that typically receive skeletal loading...
  8. Mechanisms of Neuroinflammation after Fracture
    Wade S Kingery; Fiscal Year: 2013
    ..We have developed a tibia fracture rodent model that closely replicates the CRPS clinical scenario with hindlimb unweighting, allodynia, ..
  9. The interaction of anabolic and antiresorptive agents in osteoporosis therapy
    Joy Tsai; Fiscal Year: 2013
    ..Specifically, high-resolution peripheral quantitative computed tomography of the distal tibia and radius will be used to compare the effects of combination TPTD and DMAB therapy versus each individual agent ..
  10. Bone-Specific Assessment of Marrow Cellularity by H-NMR Spectroscopy
    JOSE CARLOS PICHARDO; Fiscal Year: 2010
    ..in phantom studies and in vivo for the iliac bone, lumbar vertebrae, femoral head, and proximal end of the tibia. We propose a study in which we will use MRS on a clinical 3T scanner to expand cellularity measurements to the ..
  11. NOVEL THERAPEUTICS FOR POSTMENOPAUSAL OSTEOPOROSIS
    Ping Men; Fiscal Year: 2012
    ..g. femur, humerus, mandible, tibia and vertebra) in the animals will be collected after treatment and the treatment efficacy will be evaluated using ..
  12. Risk Factors for Osteoporosis in Children &Adolescents with Myelomeningocele
    Tishya A L Wren; Fiscal Year: 2013
    ..Bone density, size, and strength will be measured in the tibia using computed tomography (CT) imaging...
  13. Role of IGF-1 and Estrogen in Skeletal Anabolic Response to Loading
    Chandrasekhar Kesavan; Fiscal Year: 2011
    ..ML will be induced by four-point bending in the tibia or axial compression of forelimb...
  14. Bone Turnover Effects on Bisphosphonate Concentration in the Mandible
    Kenneth M Kozloff; Fiscal Year: 2012
    ..Fluorescence per bone surface area will be assessed in the mandible, femur, and tibia, and correlated with local levels of bone turnover to determine the role of turnover in the delivery, and ..
  15. (PQA1) Novel epigenetic mechanism mediate metformin inhibition of prostate cancer
    Xin Li; Fiscal Year: 2013
    ..Intra-tibia injections of miR-1-null or -overexpressed C4-2b cells will be used to determine the miR-1 mediates metformin ..
  16. Computational Biomechanics for Prediction of Osteoporotic Vertebral Fracture Risk
    Chamith Sudesh Rajapakse; Fiscal Year: 2013
    ..The proposed study makes use of mMR images of distal radius and distal tibia and midline-sagittal spine MR images in ninety eight patients with osteoporosis...
  17. Mechanical stress and skeletal plasticity after spinal cord injury in humans
    Richard K Shields; Fiscal Year: 2013
    ..Aim 1 will determine the effects of a prescribed dose of mechanical load on bone density of the tibia over 1 year following SCI. Aim 2 will determine the effects of low load vibratory mechanical stress (30 Hz, 0...
  18. Genetic Regulation of Progenitor Cells in Appendicular Skeletal Development
    Yasuhiko Kawakami; Fiscal Year: 2013
    ..outgrowth, resulted in the loss of proximal-anterior skeletal elements only in the hindlimb, such as the femur, tibia and anterior digits...
  19. The Mechanism of Coupling Bone Resorption and Formation
    Xu Cao; Fiscal Year: 2010
    ..The effects of inhibiters of RhoA and Smad signaling were tested in vivo by injection in rat tibia. Injection of the RhoA inhibitor, which promotes migration in our in vitro assays, stimulated bone formation in ..
  20. Prevention of Biofilm Related Infections Using a Novel, Broad Spectrum Antimicrob
    ROY DRAKE BLOEBAUM; Fiscal Year: 2013
    ..plate on its underside and as a unit, the fixation plate/coupon will be placed directly onto the surface of the tibia of sheep...
  21. Is impaired fracture healing in smokers related to CO exposure?
    John Wixted; Fiscal Year: 2013
    ..For severe injuries, such as open tibia fractures, reoperation rates exceed 60% in some series, and patient reported outcomes even after the fracture is ..
  22. CHANGES IN SKELETAL MICROARCHITECTURE FOLLOWING RENAL TRANSPLANTATION
    MARY BETH LEONARD; Fiscal Year: 2011
    ..Micro-MRI provides measures of trabecular microarchitecure and connectivity. The proposed study will examine tibia trabecular architecture using (MRI, and cortical BMD and dimensions using QCT in 60 young adults at the time of ..
  23. MRI-Based Assessment of Structural and Mechanical Implications of Osteoporosis
    Felix W Wehrli; Fiscal Year: 2013
    ..strength, and sub-volume trabecular bone elastic and shear moduli) derived from in vivo ?MR images at the distal tibia and radius, are associated with structural parameters expressing scale, topology and orientation at the ..
  24. Bone development and the IGF1 axis in preterm infants given massage intervention.
    Shannon L Haley; Fiscal Year: 2012
    ..We predict that infant DMT will result in improved bone mineral content (DEXA) and bone strength (tibia speed of sound), greater levels of bone formation biomarkers (osteocalcin &bone specific alkaline phosphotase) ..
  25. Kinematic and Kinetic effect of Orthotic Devices for subjects with stage II Poste
    Christopher Glenn Neville; Fiscal Year: 2012
    ..Baseline foot kinematics will be collected using a three segment foot model (first metatarsal, calcaneus, tibia) while data on ankle kinetics will be derived from the kinematic data and the ground reaction forces...
  26. Clinical Bone Mechanics Using HR-pQCT and MRI
    Felix W Wehrli; Fiscal Year: 2013
    ..Morphological measurements and 5FE predictions of stiffness and failure load of the distal tibia and radius from ex vivo 5MRI and HR-pQCT correlate highly with those from 5CT and direct mechanical testing, and, ..
  27. Magnetic Resonance Imaging of Bound and Free Water in Cortical Bone
    Jiang Du; Fiscal Year: 2013
    ..water in cortical bone (Aim 1), to evaluate the accuracy of MR measures of two groups of women cadaveric human tibia specimens, the younger group (<60 years old) and the older group (>80 years old), and correlate the results ..
  28. Osteoporosis treatment response assessed by micromechanical modeling of MRI data.
    Felix W Wehrli; Fiscal Year: 2013
    ..of LMMS for one year, will show an improvement in trabecular and cortical stiffness and failure strength at the tibia, along with a reduction in vertebral marrow adiposity relative to their placebo-treated peers...
  29. Cortical Bone Porosity Identifies Diabetes Subjects With Fragility Fractures
    Thomas M Link; Fiscal Year: 2010
    ..spatial resolution (voxel size) to visualize cortical and trabecular bone structure in vivo at the distal tibia and radius...
  30. Load-Driven Bone Lengthening
    Ping Zhang; Fiscal Year: 2010
    ..in the growth plate and lengthen the proliferative and hypertrophic zones in the distal femur and the proximal tibia? (2) Is the lengthening effect dependent on ages? (3) Does injection of insulin growth factor-2 (IGF-2) into the ..
  31. Portable 3D ultrasound for bone fracture diagnosis in emergency medicine
    FRANK WILLIAM MAULDIN; Fiscal Year: 2013
    ..device can be fabricated to achieve equivalent fracture detection performance to X-ray in an ex vivo porcine tibia-fibula fracture model...
  32. Bone Health in Pediatric Crohn Disease: A Low Magnitude Mechanical Stimulus Trial
    MARY BETH LEONARD; Fiscal Year: 2010
    ..The primary aims are to determine if treatment with LMMS results in increased trabecular vBMD (tibia and spine) and increased cortical dimensions (tibia) in children with CD, compared with controls...
  33. Adiposity and Bone Loss in Spinal Cord Injury
    Leslie R Morse; Fiscal Year: 2013
    ..In contrast, the metaphyses of the distal femur and proximal tibia (i.e., above and below the knee) are the most commonly fractured sites following SCI...
  34. Bone Fracture Risk Assessment Through Bound - and Pore - Water MRI
    Mark D Does; Fiscal Year: 2013
    ..7T) and quantitatively evaluated for use at multiple anatomical sites (e.g., distal tibia femoral neck, ...)...
  35. Wearable muscle fiber excitation system for preventing blood clot
    BERTRAM NWORAH EZENWA; Fiscal Year: 2013
    ..SEMG will be acquired with BiometricsTM surface electrodes connected to the tibia and femur muscle groups and BiometricsTM portable data acquisition system before and during MFES stimuli delivery...
  36. Changes in proximal tibia fracture strength as a function of time elapsed since s
    William Brent Edwards; Fiscal Year: 2012
    ..method based on quantitative computed tomography (CT) capable of predicting fracture strength at the proximal tibia (a location commonly fractured following SCI), and Aim 2) quantify the change in fracture strength that occurs as ..
  37. Cyclic Versus Daily Teriparatide on Bone Mass, Microstructure and Strength
    Robert Lindsay; Fiscal Year: 2013
    ..given daily for 2 years on BMD of the spine and hip by DXA and QCT and BMD and microstructure of the radius and tibia assessed by high resolution pQCT...
  38. The Interaction of Mechanical Load and Inflammation in Tendon-Bone Healing
    Scott A Rodeo; Fiscal Year: 2010
    ..use a rat model of ACL reconstruction in which a tendon graft is transplanted into bone tunnels in the femur and tibia. Graft-tunnel motion will be controlled using a specially-designed motorized loading device which will be used to ..
  39. Infection-Prevention Barriers for Osseointegrated Percutaneous Implants
    David W Grainger; Fiscal Year: 2012
    ..two designs of soft tissue-integrating flanges on osseointegrated implants with percutaneous pylons into the tibia of a porcine model: (1) a rigid microporous titanium subcutaneous flange (baseline control), and (2) a novel ..
  40. Micro-Mechanical Modeling of Trabecular Bone
    X Edward Guo; Fiscal Year: 2013
    ..of vertebral fractures, and (2) develop computationally efficient, patient-specific P-R models of whole distal tibia and radius bone segments, which will translate our findings to clinical HR-pQCT research, and (3) establish ..
  41. T-cell Mediation of Focal Bone Loss Induced by Transient Muscle Paralysis
    Brandon J Ausk; Fiscal Year: 2011
    ..These Aims will include: 1) defining the resolution of proximal tibia metaphysis trabecular image registration, 2) determining if activate T-cells are acutely up-regulated following ..
  42. MULTIAXIAL STRENGTH BEHAVIOR OF HUMAN TRABECULAR BONE
    Tony M Keaveny; Fiscal Year: 2010
    ..Other sites of interest include the proximal tibia, with particular relevance to loosening of total knee implants...
  43. MRI-BASED VIRTUAL BONE BIOPSY IN RENAL OSTEODYSTROPHY
    Felix Wehrli; Fiscal Year: 2001
    ..This pilot project proposes (1) to design and construct a u-MRI coils to assess trabecular structure in the distal tibia; (2) to develop MR-based measures of cortical thickness and cross-sectional area in the tibial diaphysis; and (3) ..
  44. Neuromuscular and positional changes after ankle joint mobilizations
    Jay N Hertel; Fiscal Year: 2010
    ..have been shown to have both positional faults at the distal tibiofibular (fibula displaced anteriorly relative to tibia) and talocrural (talus displaced anteriorly relative to tibia) joints, and impaired neuromuscular function about ..
  45. GENDER, HORMONES & ANTERIOR CRUCIATE LIGAMENT COMPLIANCE
    David Perrin; Fiscal Year: 2002
    ..be performed at incremental forces from 0-190 Newtons to determine joint displacement (forward translation of the tibia on the femur) relative to applied force...
  46. Osteocyte reaction to decreased bone fluid flow
    Shijing Qiu; Fiscal Year: 2003
    ..proposed study, the right femoral artery in 74 adult Sprague-Dawley rats will be ligated to decrease CIFF in the tibia. The animals will be sacrificed at 2, 4, 8, 48, and 168 (7days) hours after surgery...
  47. COMBINING K AND L XRF FOR IN VIVO LEAD IN BONE MEASURE
    ROBIN GARDNER; Fiscal Year: 2002
    ..In vivo measurement of lead in the tibia by X-Ray fluorescence (XRF) is the present accepted method for determining lead in the skeleton...
  48. Engineered Multi-Functional Nanofibrous Meniscus Implants
    John Esterhai; Fiscal Year: 2009
    ..this proposal, we focus on the knee meniscus, a tissue critical for proper load transfer between the femur and the tibia, and for which current repair strategies do not restore the function...
  49. HUMAN RESPONSE AND LOWER EXTREMITY INJURY
    CLAYTON MOTE; Fiscal Year: 1991
    ..The common misconception that the forces of skiing are small compared to typical tibia fracture strength and knee alignment strength will be corrected...
  50. Mechanical Intervention in Children with Cerebral Palsy
    Tishya Wren; Fiscal Year: 2005
    ..Changes in lumbar spine and proximal tibia cancellous bone density, cross-sectional properties of the midshaft of the tibia, markers of bone turnover, calf ..
  51. EPIDEMIOLOGY OF FRACTURES IN PERSONS OF AGE 45 AND OLDER
    Stephen Sidney; Fiscal Year: 2000
    ..describes a case-control study of fractures of the distal forearm, foot, proximal humerus, pelvis and shaft of the tibia and fibula among females and males of age 45 years and older in an ethnically diverse population...
  52. Stem Cell-Driven Regeneration of the Mandibular Joint
    Jeremy Mao; Fiscal Year: 2006
    ..In Specific Aim 4, autologous adult bone-marrow derived mesenchymal stem cells will be extracted from the rabbit tibia by needle aspiration, seeded in hydrogel scaffolds in the shape of rabbit mandibular condyle...
  53. 1H MRS to diagnose bone weakening from aging /inactivity
    Dieter Schellinger; Fiscal Year: 2001
    ..The goal of this proposal is to use an animal model (rat tibia) to acquire both LWR and LW as an objective method to evaluate age related bone changes and predict bone weakening...
  54. OPTIMIZATION FIXATOR STIFFNESS DURING FRACTURE HEALING
    ALFRED BEHRENS; Fiscal Year: 1993
    ..hypotheses and further develop our assessment methods, we have designed four studies: (1) We shall immobilize the tibia in a canine fracture model with 4 fixators of widely varying stiffness...
  55. Real-time Gait Retraining to Reduce Loading in Runners
    Irene Davis; Fiscal Year: 2009
    ..They will run on an instrumented treadmill with an accelerometer tightly fixed to their distal-medial tibia. With each foot strike, they will be provided with real-time visual feedback of their tibial shock...
  56. THE EFFECTS OF RETAINED LEAD BULLETS ON BODY LEAD BURDEN
    Stephen Rothenberg; Fiscal Year: 2002
    ..The patient will have K- shell X ray florescence determination of bone lead in the tibia and calcaneus in order to determine past lead exposure not revealed by medical history and risk factor ..
  57. Revitalizing Allografts for Craniofacial Reconstruction
    Edward Schwarz; Fiscal Year: 2007
    ..Although large structural allografts are commonly used for long bone replacement (tibia, femur, humerus), they remain necrotic, and thus are not usable for craniofacial reconstruction...
  58. ACOUSTIC PEDIATRIC OSTEOMETER FOR LONG BONE ASSESSMENT
    Armen Sarvazyan; Fiscal Year: 2000
    ..Probes for one- or two-way measurements will be applied to cites with thin (distal ulna, tibia) or thick (humerus, proximal femur) soft tissues layers, correspondingly...
  59. MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATION
    Paul Price; Fiscal Year: 2001
    ..They will determine the first sites of warfarin-induced abnormal calcification in the growth plate of the proximal tibia in order to establish the points at which MGP normally acts to prevent cartilage calcification...
  60. NEL-2 GENE IN BONE FORMATION & CRANIAL SUTURE CLOSURES
    Kang Ting; Fiscal Year: 2003
    ..We have also shown that rat NEL-2 is expressed in rat calvarial osteoprogenitor cells and is largely absent in rat tibia and fibroblast cell culture...
  61. CERAMIC TIBIA FOR MOBILE BEARING KNEE
    Ashok Khandkar; Fiscal Year: 1999
    ..Adaptation and enhancement of an established engineering ceramic for articulation with the established Co-Cr condylar components will greatly enhance commercial applications. ..
  62. CERAMIC TIBIA FOR MOBILE BEARING KNEE
    Michael Anderson; Fiscal Year: 2007
    ..TKA implant bearing with ultra-low wear and high safety characteristics: a CoCr femoral condyle/ with a ceramic tibia insert...
  63. PATELLO-FEMORAL MECHANICS IN PCL DEFICIENT KNEES
    Mohamed Samir Hefzy; Fiscal Year: 1992
    ..These recent reports point out that the posterior sag of the tibia that results from a PCL injury puts increased pressure on the patella, resulting in patellar pain...
  64. Community-Based Participatory Research in Environmental*
    Maria Amaya; Fiscal Year: 2005
    ..ug/dL) will be tested to determine whether the exposure is chronic using K X-ray fluorescence spectroscopy of the tibia. The etiological source of lead in the blood will also be evaluated by inductively coupled plasma - mass ..
  65. MULTISITE ULTRASONOMETER FOR OSTEOPOROSIS ASSESSMENT
    Armen Sarvazyan; Fiscal Year: 1999
    ..probes are intended for surface and through transmission sonification of short (calcaneus), long (ulna, radius, tibia) and flat (ilium) bones with prevalence of trabecular, compact or combined types of bone structure...