femur neck

Summary

Top Publications

  1. ncbi A reference standard for the description of osteoporosis
    John A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, UK
    Bone 42:467-75. 2008
  2. ncbi Quantitative computed tomographic assessment of the effects of 24 months of teriparatide treatment on 3D femoral neck bone distribution, geometry, and bone strength: results from the EUROFORS study
    Jan Borggrefe
    Medizinische Physik, Klinik für Diagnostische Radiologie, Universitatsklinikum Schleswig Holstein, Kiel, Germany
    J Bone Miner Res 25:472-81. 2010
  3. ncbi The contour of the femoral head-neck junction as a predictor for the risk of anterior impingement
    H P Nötzli
    Department of Orthopaedic Surgery, University of Zurich, Switzerland
    J Bone Joint Surg Br 84:556-60. 2002
  4. ncbi Adiponectin is associated with low bone mineral density in elderly men
    Lourdes Basurto
    Endocrine Research Unit, National Medical Center, Instituto Mexicano del Seguro Social, Cuauhtémoc 06720 Mexico
    Eur J Endocrinol 160:289-93. 2009
  5. ncbi Promoter 2 -1025 T/C polymorphism in the RUNX2 gene is associated with femoral neck bmd in Spanish postmenopausal women
    Mariona Bustamante
    Department of Genetics, University of Barcelona, Av Diagonal, 645, E 08028, Barcelona, Spain
    Calcif Tissue Int 81:327-32. 2007
  6. ncbi Bone mass and bone size in pre- or early pubertal 10-year-old black and white South African children and their parents
    L Vidulich
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Calcif Tissue Int 88:281-93. 2011
  7. ncbi Standardization of bone mineral density at femoral neck, trochanter and Ward's triangle
    Y Lu
    Department of Radiology, University of California, San Francisco 94143 0628, USA
    Osteoporos Int 12:438-44. 2001
  8. ncbi Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, UK
    Osteoporos Int 12:989-95. 2001
  9. ncbi Lumbar spine bone mineral density in US adults: demographic patterns and relationship with femur neck skeletal status
    A C Looker
    National Center for Health Statistics, Centers for Disease Control and Prevention, Room 4310, 3311 Toledo Road, Hyattsville, MD 20782, USA
    Osteoporos Int 23:1351-60. 2012
  10. ncbi Imaging findings of femoroacetabular impingement syndrome
    Douglas P Beall
    Department of Radiologal Sciences, University of Oklahoma Health Sciences Center, 825 N E 10th Street, Suite 1400, Oklahoma City, OK 73104, USA
    Skeletal Radiol 34:691-701. 2005

Research Grants

Detail Information

Publications285 found, 100 shown here

  1. ncbi A reference standard for the description of osteoporosis
    John A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, UK
    Bone 42:467-75. 2008
    ..5 SD or more below the average for young adult women. The adoption of DXA as a reference standard provides a platform on which the performance characteristics of less well established and new methodologies can be compared...
  2. ncbi Quantitative computed tomographic assessment of the effects of 24 months of teriparatide treatment on 3D femoral neck bone distribution, geometry, and bone strength: results from the EUROFORS study
    Jan Borggrefe
    Medizinische Physik, Klinik für Diagnostische Radiologie, Universitatsklinikum Schleswig Holstein, Kiel, Germany
    J Bone Miner Res 25:472-81. 2010
    ..Continuous TPTD treatment for 24 months improves FN bone strength parameters...
  3. ncbi The contour of the femoral head-neck junction as a predictor for the risk of anterior impingement
    H P Nötzli
    Department of Orthopaedic Surgery, University of Zurich, Switzerland
    J Bone Joint Surg Br 84:556-60. 2002
    ..This test may be of value in patients with loss of internal rotation for which a cause is not found...
  4. ncbi Adiponectin is associated with low bone mineral density in elderly men
    Lourdes Basurto
    Endocrine Research Unit, National Medical Center, Instituto Mexicano del Seguro Social, Cuauhtémoc 06720 Mexico
    Eur J Endocrinol 160:289-93. 2009
    ..However, little is known about the relationship between adiponectin and BMD in men. The aim of this study was to determinate the relationship between the adiponectin levels and BMD in elderly men...
  5. ncbi Promoter 2 -1025 T/C polymorphism in the RUNX2 gene is associated with femoral neck bmd in Spanish postmenopausal women
    Mariona Bustamante
    Department of Genetics, University of Barcelona, Av Diagonal, 645, E 08028, Barcelona, Spain
    Calcif Tissue Int 81:327-32. 2007
    ..001). In particular, individuals carrying the TC genotype had higher mean adjusted FN BMD values than those bearing the TT genotype. Our results highlight the importance of this RUNX2 promoter 2 polymorphism in FN BMD determination...
  6. ncbi Bone mass and bone size in pre- or early pubertal 10-year-old black and white South African children and their parents
    L Vidulich
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Calcif Tissue Int 88:281-93. 2011
    ..Heritability was comparable between environmentally disadvantaged black and advantaged white South African children and similar to that reported for Caucasians in other parts of the world...
  7. ncbi Standardization of bone mineral density at femoral neck, trochanter and Ward's triangle
    Y Lu
    Department of Radiology, University of California, San Francisco 94143 0628, USA
    Osteoporos Int 12:438-44. 2001
    ..The subregion calibration formulas are most appropriate for calibrating subregion BMD values and their absolute changes, and should be adopted. Standardization is unnecessary for BMD percentage changes in our clinical trial data...
  8. ncbi Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, UK
    Osteoporos Int 12:989-95. 2001
    ..Intervention thresholds based on hip BMD T-scores are similar between sexes...
  9. ncbi Lumbar spine bone mineral density in US adults: demographic patterns and relationship with femur neck skeletal status
    A C Looker
    National Center for Health Statistics, Centers for Disease Control and Prevention, Room 4310, 3311 Toledo Road, Hyattsville, MD 20782, USA
    Osteoporos Int 23:1351-60. 2012
    ..Prevalence of low spine BMD and agreement between the prevalence of low BMD at the spine and femur neck in older adults are also assessed.
  10. ncbi Imaging findings of femoroacetabular impingement syndrome
    Douglas P Beall
    Department of Radiologal Sciences, University of Oklahoma Health Sciences Center, 825 N E 10th Street, Suite 1400, Oklahoma City, OK 73104, USA
    Skeletal Radiol 34:691-701. 2005
    ..In this paper, we will introduce these risk factors, the proposed supportive imaging criteria, and the ultimate interventions that can help alleviate patients' symptoms...
  11. ncbi Effect of a calcium and exercise intervention on the bone mineral status of 16-18-y-old adolescent girls
    Samantha J Stear
    MRC Human Nutrition Research, Cambridge, United Kingdom
    Am J Clin Nutr 77:985-92. 2003
    ..Osteoporosis may be prevented or delayed by maximizing peak bone mass through diet modification and physical activity during adolescence...
  12. pmc Proximal femoral anatomy in the normal human population
    Paul A Toogood
    Department of Orthopaedics, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, 2423 Overlook Road, Apartment 7, Cleveland Heights, OH 44106, USA
    Clin Orthop Relat Res 467:876-85. 2009
    ..23 degrees , respectively. Differences existed between males and females and between those younger and older than 50 years. Correlations were observed between translation and concavity, and translation and the neck-shaft relationships...
  13. ncbi Absolute fracture risk assessment using lumbar spine and femoral neck bone density measurements: derivation and validation of a hybrid system
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 26:460-7. 2011
    ..The improvement in fracture risk prediction is small but supports clinical interest in a system that integrates LS in fracture risk assessment...
  14. ncbi Relationship between physical activity and bone mineral status in young adults: the Northern Ireland Young Hearts Project
    C E Neville
    School of Applied Medical Sciences and Sports Studies, University of Ulster, Jordanstown, Shore Road, Newtownabbey BT37 0QB, Northern Ireland, UK
    Bone 30:792-8. 2002
    ..Intervention studies are warranted to determine whether peak bone density in women can be improved by participating, during childhood and adolescence, in sports activities involving high peak strain...
  15. ncbi Recombinant human parathyroid hormone (1-34) [teriparatide] improves both cortical and cancellous bone structure
    Yebin Jiang
    Osteoporosis and Arthritis Research Group, Department of Radiology, University of California, San Francisco, California 94143 0628, USA
    J Bone Miner Res 18:1932-41. 2003
    ....
  16. ncbi Bivariate whole genome linkage analysis for femoral neck geometric parameters and total body lean mass
    Fei Yan Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    J Bone Miner Res 22:808-16. 2007
    ..A genome-wide bivariate analysis was conducted for femoral neck GPs and TBLM in a large white sample. We found QTLs shared by GPs and TBLM in the total sample and the sex-specific samples. QTLs with potential pleiotropy were also disclosed...
  17. ncbi Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial
    S R Cummings
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    JAMA 280:2077-82. 1998
    ..Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied for women without vertebral fractures...
  18. ncbi Levels of physical activity that predict optimal bone mass in adolescents: the HELENA study
    Luis Gracia-Marco
    GENUD Growth, Exercise, NUtrition and Development Research Group, School of Health Science, University of Zaragoza, Aveñida Domingo Miral s n, Zaragoza, Spain
    Am J Prev Med 40:599-607. 2011
    ..Physical activity is necessary for bone mass development in adolescence. There are few studies quantifying the associations between physical activity and bone mass in adolescents...
  19. ncbi Trabecular bone modulus-density relationships depend on anatomic site
    Elise F Morgan
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, 6175 Etcheverry Hall, Berkeley, CA 94720 1740, USA
    J Biomech 36:897-904. 2003
    ..15), suggesting that the site-specificity in apparent modulus-density relationships may be attributed to differences in architecture...
  20. ncbi Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight
    Thomas F Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Bone Miner Res 21:1224-30. 2006
    ..We observed that the readaptation of the proximal femur to Earth's gravity entailed an increase in bone size and an incomplete recovery of volumetric BMD...
  21. ncbi The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    Pierre J Meunier
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
    N Engl J Med 350:459-68. 2004
    ....
  22. ncbi Association of functionally different RUNX2 P2 promoter alleles with BMD
    James D Doecke
    School of Medical Science, Gold Coast Campus, Griffith University, Queensland, Australia
    J Bone Miner Res 21:265-73. 2006
    ..Of 16 SNPs in RUNX2 and its two promoters (P1 and P2), only SNPs in the P2 promoter were significantly associated with BMD. These P2 promoter SNPs were functionally different in gel-shift and promoter activity assays...
  23. ncbi Effects of different impact exercise modalities on bone mineral density in premenopausal women: a meta-analysis
    Marrissa Martyn-St James
    Carnegie Faculty of Sport and Education, Leeds Metropolitan University, Leeds, UK
    J Bone Miner Metab 28:251-67. 2010
    ..High-impact-alone protocols are effective only on hip BMD in this group. However, diverse methodological and reporting discrepancies are evident in published trials...
  24. pmc The differences of femoral neck geometric parameters: effects of age, gender and race
    F Zhang
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People s Republic of China
    Osteoporos Int 21:1205-14. 2010
    ....
  25. ncbi Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls
    Mitsuru Saito
    Department of Orthopaedic Surgery, Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Tokyo, Japan
    Calcif Tissue Int 79:160-8. 2006
    ..These results indicate that detrimental crosslinking in both low and high mineralized bone result in impaired bone quality in osteoporotic patients...
  26. ncbi Changing structure of the femoral neck across the adult female lifespan
    Kenneth E S Poole
    Department of Medicine, University of Cambridge, Box 157, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    J Bone Miner Res 25:482-91. 2010
    ..It remains to be determined whether this MDCT technique can provide better prediction of hip fracture than conventional clinical dual X-ray absorptiometry (DXA)...
  27. ncbi Prevalence of osteoporosis and reference data for lumbar spine and hip bone mineral density in a Korean population
    Lian Hua Cui
    Department of Public Health, Qingdao University Medical College, Qingdao, China
    J Bone Miner Metab 26:609-17. 2008
    ..This study establishes a normative database for BMD at central skeletal sites using dual-energy X-ray absorptiometry and provides more reliable information on the prevalence of osteoporosis in Korea...
  28. ncbi Relationship between change in femoral neck bone mineral density and hip fracture incidence during treatment with strontium ranelate
    O Bruyere
    Department of Epidemiology, Public Health and Health Economics, University of Liege, Belgium
    Curr Med Res Opin 23:3041-5. 2007
    ..The objective of this study is to analyse the association between BMD changes and hip fracture incidence during treatment with SR...
  29. pmc Mid-term results of 155 patients treated with a collum femoris preserving (CFP) short stem prosthesis
    Daniel Briem
    Endoclinic Hamburg, Hamburg, Germany
    Int Orthop 35:655-60. 2011
    ..With regard to outcome, survivorship and complication rate, the medium-term results of the CFP prosthesis are promising...
  30. ncbi Absolute fracture-risk prediction by a combination of calcaneal quantitative ultrasound and bone mineral density
    Mei Y Chan
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
    Calcif Tissue Int 90:128-36. 2012
    ..These results suggest that calcaneal QUS is an independent predictor of fracture risk and that a combination of QUS and BMD measurement could improve the predictive accuracy of fracture risk in elderly women...
  31. ncbi Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over
    H Blain
    , , CHU Montpellier, France
    Gerontology 47:207-12. 2001
    ..These results suggest a site-specific effect of muscular strength on bone and a potential role of the age-related decline of muscle strength in age-related bone loss in postmenopausal women...
  32. ncbi Dependence of yield strain of human trabecular bone on anatomic site
    E F Morgan
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, 2166 Etcheverry Hall, Berkeley, CA 94720 1740, USA
    J Biomech 34:569-77. 2001
    ..These results establish that the yield strains of human trabecular bone can differ across sites, but that yield strain may be considered uniform within a given site despite substantial variation in elastic modulus and yield stress...
  33. ncbi Association between bone mineral density and metabolic syndrome in pre- and postmenopausal women
    Yun Kyung Jeon
    Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea
    Endocr J 58:87-93. 2011
    ..Inflammation might have a more important role in BMD than obesity in the postmenopausal women...
  34. pmc Knee loading stimulates healing of mouse bone wounds in a femur neck
    Ping Zhang
    Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 49:867-72. 2011
    ..in mouse femora and tibiae, we addressed a question: Does knee loading accelerate a closure of open wounds in a femur neck? A surgical wound (0...
  35. ncbi Does childhood and adolescence fracture influence bone mineral content in young adulthood?
    Chantal E Kawalilak
    College of Kinesiology, University of Saskatchewan, Saskatoon, SK S7N 5B2, Canada
    Appl Physiol Nutr Metab 35:235-43. 2010
    ..These results suggest that fractures sustained during childhood and adolescence may not interfere with bone mass in young adulthood at clinically relevant bone sites...
  36. ncbi COL1A1 Sp1 polymorphism predicts perimenopausal and early postmenopausal spinal bone loss
    H M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, United Kingdom
    J Bone Miner Res 16:1634-41. 2001
    ..0%), weight (5.0%), and baseline BMD (2.8%). We conclude that women homozygous for the Sp1 polymorphism are at significantly increased risk of excess rates of bone loss at the spine, but this effect may be nullified by the use of HRT...
  37. ncbi The prevalence of significant left-right differences in hip bone mineral density
    R Hamdy
    Osteoporosis Center, College of Medicine, East Tennessee State University and VAMC, Johnson City, TN, USA
    Osteoporos Int 17:1772-80. 2006
    ....
  38. pmc Hip structural geometry and incidence of hip fracture in postmenopausal women: what does it add to conventional bone mineral density?
    A Z LaCroix
    WHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Osteoporos Int 21:919-29. 2010
    ....
  39. ncbi Acetabular and femoral radiographic abnormalities associated with labral tears
    Michael W Peelle
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Orthop Relat Res 441:327-33. 2005
    ..See the Guidelines for Authors for a complete description of levels of evidence...
  40. ncbi A meta-analysis of brief high-impact exercises for enhancing bone health in premenopausal women
    O O Babatunde
    Centre for Sport, Health and Exercise Research, Staffordshire University, Leek Road, Stoke on Trent ST4 2DF, UK
    Osteoporos Int 23:109-19. 2012
    ....
  41. ncbi Association of the collagen type 1 (COL1A 1) Sp1 binding site polymorphism to femoral neck bone mineral density and wrist fracture in 1044 elderly Swedish women
    P Gerdhem
    Department of Orthopedics, Lund University, Malmo University Hospital, Malmo, Sweden
    Calcif Tissue Int 74:264-9. 2004
    ..The presence of at least one copy of the "s" allele was associated with lower femoral neck BMD and previous wrist fracture and in addition, it was related to an increased risk for wrist fracture...
  42. ncbi Cementless CUT femoral neck prosthesis: increased rate of aseptic loosening after 5 years
    Stephan Albrecht Ender
    Department of Orthopedic Surgery, Otto von Guericke University, Magdeburg, Germany
    Acta Orthop 78:616-21. 2007
    ..Bone-saving hip arthroplasty techniques, which facilitate revision, are gaining importance as the number of hip replacements in younger patients increases...
  43. pmc Clinical risk factor assessment had better discriminative ability than bone mineral density in identifying subjects with vertebral fracture
    S W Y Tsang
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Osteoporos Int 22:667-74. 2011
    ..The findings provide further insights into possible development of a simple, cost-effective scheme for fracture risk assessment using clinical risk factors to identify high-risk patients for further evaluation...
  44. ncbi [ESKA (CUT) endoprosthesis]
    W Thomas
    Chirurgia Ortopedica, Clinica Quisisana, Rom
    Orthopade 33:1243-8. 2004
    ..Should the need arise to change the endoprosthesis, an endoprosthetic stem anchored in the diaphysis can easily be implanted after resection of the femoral neck near the base...
  45. ncbi Meta-analysis of walking for preservation of bone mineral density in postmenopausal women
    Marrissa Martyn-St James
    Carnegie Faculty of Sport and Education, Leeds Metropolitan University, Room 202, Fairfax Hall, Headingley Campus, Leeds LS6 3QT, UK
    Bone 43:521-31. 2008
    ..Other forms of exercise that provide greater targeted skeletal loading may be required to preserve bone mineral density in this population...
  46. ncbi An investigation of the diagnostic value of bilateral femoral neck bone mineral density measurements
    G W Petley
    Department of Medical Physics and Bioengineering, Southampton University Hospitals NHS Trust, UK
    Osteoporos Int 11:675-9. 2000
    ..Since BMD measurements are only one of a range of factors considered as part of a patient's management, it is suggested that the extra time, cost and radiation dose associated with measurement of the second femur may not be justified...
  47. ncbi Contribution of hip strength indices to hip fracture risk in elderly men and women
    Henrik G Ahlborg
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia, and Department of Orthopaedics, Malmo University Hospital, Sweden
    J Bone Miner Res 20:1820-7. 2005
    ..However, the contribution of each of these indices to hip fracture prediction was modest in the presence of BMD...
  48. ncbi Influence of calcium intake and physical activity on proximal femur bone mass and structure among pre- and postmenopausal women. A 10-year prospective study
    Kirsti Uusi-Rasi
    The UKK Institute, P O Box 30, 33501 Tampere, Finland
    Calcif Tissue Int 82:171-81. 2008
    ..High calcium intake seemed to slow the decline in trochanter BMC in premenopausal women, while high physical activity was beneficial for proximal femur, particularly among older women...
  49. ncbi Maintenance of muscle strength may counteract weight-loss-related postmenopausal bone loss--a population-based approach
    J Sirola
    Bone and Cartilage Research Unit BCRU, University of Kuopio, MediTeknia Building, P O Box 1627, 70211, and Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    Osteoporos Int 17:775-82. 2006
    ....
  50. pmc Distribution of cortical bone in the femoral neck and hip fracture: a prospective case-control analysis of 143 incident hip fractures; the AGES-REYKJAVIK Study
    Fjóla Jóhannesdóttir
    University of Iceland, Reykjavik, Iceland
    Bone 48:1268-76. 2011
    ..In conclusion, Est CTh in the SA quadrant best discriminated cases (n=143) from controls (n=298), especially in men. Cortical thinning superiorly in the hip might be of importance in determining resistance to fracture...
  51. ncbi Three-dimensional magnetic resonance imaging analysis of hip morphology in the assessment of femoral acetabular impingement
    E C Kavanagh
    Department of Radiology, Mater Misericordiae Hospital, Dublin, Ireland
    Clin Radiol 66:742-7. 2011
    ..To determine a possible association between femoral-acetabular impingement (FAI) volume and the development of labral tear using a three-dimensional (3D) model reconstruction of the acetabulum and the femoral head...
  52. ncbi Contributions of bone density and structure to fracture risk assessment in men and women
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 16:460-7. 2005
    ..Because of the strong correlations, however, some judgment can be used in selecting the variables easiest to measure...
  53. ncbi Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA org
    J Clin Endocrinol Metab 87:3057-67. 2002
    ..Femoral neck BMD is highest in African-Americans and similar in Chinese, Japanese, and Caucasians. These findings may explain why Caucasian women have higher fracture rates than African-Americans and Asians...
  54. pmc Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry
    Yuan Chen
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi 710049, PR China
    Bone 46:129-36. 2010
    ..Overall, these results suggest the significant genetic contribution of EphrinA-EphR pathway to femoral neck bone geometry...
  55. ncbi Vitamin D insufficiency does not affect response of bone mineral density to alendronate
    D M Antoniucci
    Department of Medicine, San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Osteoporos Int 20:1259-66. 2009
    ..We found that vitamin D insufficiency is common among patients with low bone density but that vitamin D insufficiency did not impair response to alendronate...
  56. ncbi Herniation pits and cystic-appearing lesions at the anterior femoral neck: an anatomical study by MSCT and microCT
    Stephanie Panzer
    Department of Radiology, Trauma Center Murnau, Prof Küntscher Strasse 8, 82418 Murnau, Germany
    Skeletal Radiol 39:645-54. 2010
    ..To determine distinguishing features between herniation pits (HPs) and other cystic-appearing lesions at the anterior femoral neck in multi-slice computed tomography (MSCT) and micro-computed tomography (microCT) examinations...
  57. ncbi Fibrocystic changes at anterosuperior femoral neck: prevalence in hips with femoroacetabular impingement
    Michael Leunig
    Department of Orthopedic Surgery, University of Berne, Inselspital, CH 3010 Berne, Switzerland
    Radiology 236:237-46. 2005
    ..To retrospectively evaluate if there is an association between juxta-articular fibrocystic changes at the anterosuperior femoral neck and femoroacetabular impingement (FAI)...
  58. ncbi The contributions of lean tissue mass and fat mass to bone geometric adaptation at the femoral neck in Chinese overweight adults
    Shan Wu
    Hunan Normal University Changsha, Hunan P R China
    Ann Hum Biol 34:344-53. 2007
    ..Thus, the influence of body weight on bone geometry was examined in Chinese overweight adults...
  59. ncbi Nonspherical femoral head shape (pistol grip deformity), neck shaft angle, and risk of hip osteoarthritis: a case-control study
    Michael Doherty
    University of Nottingham, Nottingham University Hospitals Trust, Nottingham, UK
    Arthritis Rheum 58:3172-82. 2008
    ..To determine whether 2-dimensional measures of femoral head shape and angle are associated with hip osteoarthritis (OA)...
  60. ncbi Evaluation of a prediction model for long-term fracture risk
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:551-6. 2005
    ..The NOF cost-effectiveness model, based on clinical risk factors and femoral neck aBMD, predicted overall fracture risk in a cohort of postmenopausal women followed for up to 22 years...
  61. ncbi High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nutr Res 29:221-8. 2009
    ..The review of the reliable literature confirmed the effect of vitamin K(1) and vitamin K(2) supplementation on the skeleton of postmenopausal women mediated by mechanisms other than bone mineral density and bone turnover...
  62. pmc Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis
    P J Meunier
    Faculty Laennec, Claude Bernard University, Rue G Paradin, 69437, Lyon Cedex 03, France
    Osteoporos Int 20:1663-73. 2009
    ....
  63. ncbi Effect of low-repetition jump training on bone mineral density in young women
    Takeru Kato
    Department of Clinical Nutrition, Faculty of Health Science, Suzuka Univ of Medical Science, Kishioka, 1001 1, Suzuka 510 0293, Japan
    J Appl Physiol (1985) 100:839-43. 2006
    ..From the results of the present study, low-repetition and high-impact jumps enhanced BMD at the specific bone sites in young women who had almost reached the age of peak bone mass...
  64. ncbi CLINICAL Review # : low body weight mediates the relationship between HIV infection and low bone mineral density: a meta-analysis
    Mark J Bolland
    Osteoporosis Research Group, Department of Medicine, University of Auckland, Private Bag 92 019, Auckland, New Zealand
    J Clin Endocrinol Metab 92:4522-8. 2007
    ..The cross-sectional studies may have been confounded by the failure to control for low body weight in HIV-infected patients...
  65. ncbi Prevalence and risk factors of osteoporosis in Korea: a community-based cohort study with lumbar spine and hip bone mineral density
    Chan Soo Shin
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Bone 47:378-87. 2010
    ..To investigate bone mineral density (BMD) profiles, osteoporosis prevalence and risk factors in a community-based cohort in Korea...
  66. ncbi Correlations between biochemical markers of bone turnover and bone density responses in patients with glucocorticoid-induced osteoporosis treated with teriparatide or alendronate
    Alan L Burshell
    Ochsner Clinic Foundation, Endocrinology Department, 9S Lobby Tower, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Bone 46:935-9. 2010
    ..With both therapies, early changes in some bone turnover markers were correlated with 18-month gains in BMD in patients with GIO...
  67. ncbi Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study
    I I de Liefde
    Department of Internal Medicine, Erasmus Medical Centre, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Osteoporos Int 16:1713-20. 2005
    ..Whereas, subjects with IGT have a decreased fracture risk, subjects with DM (primarily those with already established and treated DM) had an increased fracture risk, probably due to long-term complications associated with DM...
  68. ncbi Targeted exercises against hip fragility
    R Nikander
    Bone Research Group, UKK Institute for Health Promotion Research, 33501 Tampere, Finland
    Osteoporos Int 20:1321-8. 2009
    ..Since odd-impact exercises are mechanically less demanding to the body, this type of exercise can provide a reasonable basis for devising feasible, targeted bone training against hip fragility...
  69. pmc Physical activity and femoral neck bone strength during childhood: the Iowa Bone Development Study
    Kathleen F Janz
    Department of Health and Sport Studies, The University of Iowa, Iowa City, Iowa, USA
    Bone 41:216-22. 2007
    ..These results suggest that physical activity is an important contributor to bone strength prior to adolescence and that increasing levels of physical activity during childhood are likely to enhance optimal bone strength...
  70. ncbi Bone mineral density in adolescent female athletes: relationship to exercise type and muscle strength
    Craig S Duncan
    University of Sydney, Sydney, Australia
    Med Sci Sports Exerc 34:286-94. 2002
    ..Associations between leg strength and BMD were also examined...
  71. ncbi Hip fractures and the contribution of cortical versus trabecular bone to femoral neck strength
    Gerold Holzer
    Department of Orthopaedics, Medical University of Vienna, Vienna, Austria
    J Bone Miner Res 24:468-74. 2009
    ....
  72. ncbi Relation between age, femoral neck cortical stability, and hip fracture risk
    Paul M Mayhew
    Department of Medicine, University of Cambridge, Cambridge, UK
    Lancet 366:129-35. 2005
    ..We aimed to measure whether elastic instability increases greatly with age since it might trigger hip fracture in a sideways fall...
  73. ncbi Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis
    J J Stepan
    Institute of Rheumatology, Faculty of Medicine, Charles University, Na Slupi 4, CZ12850, Prague, Czech Republic
    Osteoporos Int 21:2027-36. 2010
    ....
  74. ncbi Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials
    Kyoko Taku
    Information Center, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Asia Pac J Clin Nutr 19:33-42. 2010
    ..Soy isoflavone extract supplements increased lumbar spine BMD in menopausal women. Further studies are needed to address factors affecting the magnitudes of effect on spine and to verify the effect on hip...
  75. ncbi Elevated serum levels of soluble receptor activator of nuclear factors-kappaB ligand (sRANKL) and reduced bone mineral density in patients with ankylosing spondylitis (AS)
    H R Kim
    Division of Rheumatology, Department of Internal Medicine, Konkuk University Hospital, 4 12 Hwayang dong, Gwangjin gu, Seoul 143 729, Korea
    Rheumatology (Oxford) 45:1197-200. 2006
    ....
  76. ncbi Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women
    Richard L Prince
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Arch Intern Med 166:869-75. 2006
    ..We have examined whether calcium supplementation decreases clinical fracture risk in elderly women and its mechanism of action...
  77. pmc Investigation of sex differences in hip structure in peripubertal children
    Adrian Sayers
    Academic Rheumatology, Clinical Science at North Bristol, University of Bristol, and Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 95:3876-83. 2010
    ..There is evidence that sex differences in hip structure are increased during puberty, possibly as a consequence of associated changes in body composition...
  78. ncbi Noninvasive three-dimensional assessment of femoroacetabular impingement
    Moritz Tannast
    Center for Computer Assisted and Reconstructive Surgery, New England Baptist Hospital, Tufts University, Harvard Medical School, Boston, Massachusetts, USA
    J Orthop Res 25:122-31. 2007
    ....
  79. ncbi BMD, clinical risk factors and their combination for hip fracture prevention
    H Johansson
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Osteoporos Int 20:1675-82. 2009
    ....
  80. ncbi Relation between hormones and body composition, including bone, in prepubertal children
    Sarah P Garnett
    Institute of Endocrinology and Diabetes and the Research and Development Office, The Children s Hospital at Westmead, Westmead, Australia
    Am J Clin Nutr 80:966-72. 2004
    ..However, data are lacking that address the extent to which concentrations of these hormones influence body composition, bone mass, and density in prepubertal children...
  81. ncbi Self-reported ballet classes undertaken at age 10-12 years and hip bone mineral density in later life
    K M Khan
    Department of Medicine, Royal Melbourne Hospital, Australia
    Osteoporos Int 8:165-73. 1998
    ..The findings are consistent with the hypothesis that this age range identifies a stage of development when the proximal femur is particularly responsive to weightbearing exercise...
  82. ncbi Soymilk or progesterone for prevention of bone loss--a 2 year randomized, placebo-controlled trial
    Eva Lydeking-Olsen
    Institute for Optimum Nutrition, Teglgaardstraede 4, 1st Floor, 1452, Copenhagen K, Denmark
    Eur J Nutr 43:246-57. 2004
    ..Progesterone has been suggested as a bone-trophic hormone, but the effect of long-term, low dose transdermal progesterone is unknown...
  83. ncbi Strength training preserves the bone mineral density of postmenopausal women without hormone replacement therapy
    Danilo Sales Bocalini
    Federal University of São Paulo and Heart Institute, Medical School of Sao Paulo University, Rue General Chagas Santos 392, CEP 04146 050 São Paulo, Brazil
    J Aging Health 21:519-27. 2009
    ..The study was designed to evaluate the effects of strength training (ST) on the bone mineral density (BMD) of postmenopausal women without hormone replacement therapy...
  84. pmc Tracking of bone mass and density during childhood and adolescence
    Heidi J Kalkwarf
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Clin Endocrinol Metab 95:1690-8. 2010
    ..The stability of a characteristic during growth is referred to as "tracking."..
  85. ncbi Long-term treatment of postmenopausal osteoporosis with strontium ranelate: results at 8 years
    J Y Reginster
    Department of Public Health Sciences, University of Liege, Liege, Belgium
    Bone 45:1059-64. 2009
    ..This article describes the efficacy, safety, and tolerability of this agent over 8 years...
  86. ncbi Teriparatide [PTH(1-34)] strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosity
    Masahiko Sato
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    J Bone Miner Res 19:623-9. 2004
    ..Beneficial effects of teriparatide treatment on the proximal femur persisted beyond the treatment period and may extend to the marrow...
  87. ncbi Effect of long-term intervention of soy isoflavones on bone mineral density in women: a meta-analysis of randomized controlled trials
    Jing Liu
    Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat Sen University, Guangzhou, China
    Bone 44:948-53. 2009
    ..A number of RCTs have examined the role of soy isoflavones on bone mineral density (BMD) and yielded inconsistent results. This meta-analyses aims to assess the overall effect of soy isoflavones on BMD...
  88. pmc Do normal radiographs exclude asphericity of the femoral head-neck junction?
    Marcel Dudda
    Department of Orthopaedic Surgery, Inselspital, University of Berne, Freiburgstrasse, 3010, Bern, Switzerland
    Clin Orthop Relat Res 467:651-9. 2009
    ..Even when conventional radiographs appeared normal, an increased alpha angle was present anterosuperiorly. Without the use of radial slices in MRA, the asphericity would be underestimated in these patients...
  89. ncbi Risk factors associated with peri- and postmenopausal bone loss: does HRT prevent weight loss-related bone loss?
    J Sirola
    Research Institute of Public Health, University of Kuopio, Finland
    Osteoporos Int 14:27-33. 2003
    ..Furthermore, HRT seems to be effective in prevention of weight loss related bone loss...
  90. ncbi The effects of parathyroid hormone, alendronate, or both in men with osteoporosis
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
    N Engl J Med 349:1216-26. 2003
    ..Because parathyroid hormone increases both bone formation and bone resorption, it is possible that combining parathyroid hormone with an antiresorptive agent will enhance its effect on bone mineral density...
  91. ncbi Bone mineral density in acute stroke patients: low bone mineral density may predict first stroke in women
    L Jørgensen
    Institute of Community Medicine, University of Tromsø, Norway
    Stroke 32:47-51. 2001
    ..Thus, low bone mineral density (BMD) and high stroke risk may be related. We examined the relationship between BMD and acute stroke in noninstitutionalized men and women aged >/=60 years...
  92. ncbi Association between COLIA1 Sp1 alleles and femoral neck geometry
    A M Qureshi
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Foresterhill, UK
    Calcif Tissue Int 69:67-72. 2001
    ..The association COLIAI genotype and increased femoral neck angle noted here may therefore contribute to the BMD-independent increase in hip fracture risk noted in previous studies of individuals who carry the 's' allele...
  93. ncbi Cross-calibration of dual-energy X-ray densitometers for a large, multi-center genetic study of osteoporosis
    D M Reid
    Department of Medicine and Therapeutics, Medical School, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Osteoporos Int 17:125-32. 2006
    ....
  94. ncbi Notching of the femoral neck during resurfacing arthroplasty of the hip: a vascular study
    P E Beaulé
    Joint Replacement Institute at Orthopaedic Hospital, 2400 South Flower Street, Los Angeles, CA 90007, USA
    J Bone Joint Surg Br 88:35-9. 2006
    ..Surgeons who perform resurfacing arthroplasty of the hip should pay careful attention to these vessels by avoiding excessive dissection around the femoral neck and/or notching...
  95. ncbi [Herniation pits and their renaissance in association with femoroacetabular impingement]
    S Panzer
    Radiologie, Unfallklinik Murnau
    Rofo 182:565-72. 2010
    ..In summary, HPs should always be recognized and documented because they may contribute to the diagnosis of FAI which is essential for preventing or delaying osteoarthritis of the hip joint in the early stage...
  96. ncbi Relationship between 3-month changes in biochemical markers of bone remodelling and changes in bone mineral density and fracture incidence in patients treated with strontium ranelate for 3 years
    O Bruyere
    Department of Public Health, Epidemiology and Health Economics, CHU Sart Tilman, University of Liege, Bat B23, 4000 Liege, Belgium
    Osteoporos Int 21:1031-6. 2010
    ....
  97. pmc Early changes in biochemical markers of bone turnover and their relationship with bone mineral density changes after 24 months of treatment with teriparatide
    A Blumsohn
    Department of Clinical Biochemistry, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
    Osteoporos Int 22:1935-46. 2011
    ..Prior therapy does not adversely affect the response to teriparatide treatment. Similar bone markers levels are reached after 6 months of treatment...
  98. ncbi Herniation pits in the femoral neck: a radiographic indicator of femoroacetabular impingement?
    Jin Ah Kim
    Department of Radiology, Kyung Hee University Medical Center, Kyung Hee University, Hoeki Dong 1, Dongdaemoon Ku, Seoul, 130 702, Korea
    Skeletal Radiol 40:167-72. 2011
    ..Therefore it can be concluded that an incidental finding of herniation pits does not necessarily imply a correlation with FAI...
  99. ncbi During sideways falls proximal femur fractures initiate in the superolateral cortex: evidence from high-speed video of simulated fractures
    Peter M de Bakker
    Department of Mechanical Engineering, Centre for Hip Health and Mobility, University of British Columbia, Vancouver, Canada
    J Biomech 42:1917-25. 2009
    ..Our results confirm the superolateral neck of the femur as an important region of interest for future hip fracture screening, prevention and treatment research...
  100. ncbi Femoroacetabular impingement: bone marrow oedema associated with fibrocystic change of the femoral head and neck junction
    S L J James
    Department of Radiology, RNOH Stanmore, Stanmore, Middlesex, UK
    Clin Radiol 62:472-8. 2007
    ..To describe the association of bone marrow oedema adjacent to areas of fibrocystic change at the femoral head and neck junction in patients with femoroacetabular impingement...
  101. ncbi Site-specific differences in bone mineral density in black and white premenopausal South African women
    S Chantler
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, P O Box 115, Newlands 7725, South Africa
    Osteoporos Int 23:533-42. 2012
    ..Femoral neck and total hip BMD were higher, but lumbar spine BMD was lower in black women, with body composition, lifestyle and socioeconomic status (SES) factors contributing differently in ethnic groups...

Research Grants66

  1. EXERCISE AND BLOOD PRESSURE IN CHILDREN: A META-ANALYSIS
    George Kelley; Fiscal Year: 2001
    ..The investigators state that the results of this project will provide clarification regarding the role of exercise in reducing resting systolic and diastolic blood pressure in children and adolescents. ..
  2. Aerobic Exercise, Diet and Cholesterol: A Meta-Analysis
    George A Kelley; Fiscal Year: 2010
    ..This is important since one of the major goals of the Department of Health and Human Services is to increase the quality and years of healthy life. ..
  3. Effect of hormonal contraception on bone mineral density
    Abbey Berenson; Fiscal Year: 2005
    ..Ultimately, this study will determine which women, if any, are placed at increased risk of osteopenia or osteoporosis as a result of using these hormonal contraceptives during their reproductive years. ..
  4. DEPO PROVERA AND BONE MINERAL DENSITY IN ADOLESCENTS
    Barbara Cromer; Fiscal Year: 2003
    ..The statistical analysis will estimate the effect of DMPA on bone density while taking account of constant treatment discontinuation throughout the study period. ..
  5. Intensive Glycemic Control and Skeletal Health
    Ann Schwartz; Fiscal Year: 2009
    ..Change in bone mineral density over two years at the hip and lumbar spine will be determined in a subsample (N=240) using dual energy absorptiometry (DEXA). ..
  6. DIABETES, PRE-DIABETES, AND FALLS IN OLDER ADULTS
    Ann Schwartz; Fiscal Year: 2004
    ..These analyses will inform future efforts to design trials to prevent falls and maintain strength and balance in older adults with diabetes or pre-diabetes. ..
  7. Effects of EECP on Arterial Function
    RANDY BRAITH; Fiscal Year: 2006
    ..Only through identification of specific mechanisms behind the efficacy of EECP, will this treatment oDtion receive acceptance by the clinical community in the treatment of svmptomatic CAD. ..
  8. NIH OSTEOPOROSIS & RELATED BONE DISEASES RESOURCE CENTER
    Bess Dawson Hughes; Fiscal Year: 2002
    ..Specific efforts include supporting the National Osteoporosis Data Group, collecting and disseminating definitive statistics on bone diseases and on conditions co-morbid with osteoporosis, and preparing summary reports. ..
  9. EFFECT OF POTASSIUM BICARBONATE ON BONE AND MUSCLE
    Bess Dawson Hughes; Fiscal Year: 2008
    ....
  10. VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSIS
    Sarah Booth; Fiscal Year: 2001
    ..Results of the studies proposed could lead to effective intervention programs that reduce bone loss resulting in a decreased risk and incidence of osteoporosis. ..
  11. Dietary & non-dietary components of vitamin K metabolism
    Sarah Booth; Fiscal Year: 2008
    ..The findings of the proposed study are critical for the interpretation of the epidemiologic and clinical data used to determine optimal intakes at which vitamin K may have a protective role in bone health. ..
  12. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2004
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  13. Flavocoxid: A Medical Food Therapy for Osteoarthritis
    Sarah Morgan; Fiscal Year: 2004
    ..This innovative compound has commercial potential with its expected efficacy comparable to or exceeding the currently marketed COX inhibitors but with fewer side effects and at a significantly lower cost. ..
  14. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2005
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  15. Genetics of Menopause - A Pilot Study
    Siu Hui; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  16. Spectroscopic X-ray Bone Densitometry
    Thomas Beck; Fiscal Year: 2008
    ..The disease is characterized by low bone mass, leading to enhanced bone fragility and a significant increase in the risk of fractures, which is typically diagnosed by bone densitometer [1,2]. [unreadable] [unreadable] [unreadable]..
  17. Bone Geometry, Body Composition and Sex Hormones in Men
    Lynn Marshall; Fiscal Year: 2005
    ..The proposed project will yield new information about factors that influence bone geometry among older men. ..
  18. Factors Affecting the Bone Response and Non-Response
    Laura Milliken; Fiscal Year: 2003
    ..Additionally, we will better understand the pattern of the BMD response over longer periods of time and will be able to identify factors that may relate to the likelihood of responding to a given treatment. ..
  19. EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONE
    Joel Finkelstein; Fiscal Year: 2008
    ..Without continued K24 support, I will need to increase my clinical activities, reduce my research time, and forego training of new clinical investigators. ..
  20. Estrogen Regulation of the Bone Marrrow Adipocyte
    Sundeep Khosla; Fiscal Year: 2010
    ....
  21. Bone Quality in Hypoparathyroidism: Effects of PTH
    Mishaela Rubin; Fiscal Year: 2008
    ..abstract_text> ..
  22. Statistical Methods for Evaluation and Validation of Diagnostic Tests
    Ying Lu; Fiscal Year: 2008
    ..Research results will be disseminated through publication of software, research and tutorial papers in both clinical and statistical journals and by influencing position papers of professional organizations. ..
  23. The Yoga for Hyperkyphosis Trial
    Gail Greendale; Fiscal Year: 2007
    ..At the end of this phase we will again measure study endpoints to assess whether participants have maintained the physical function achieved at the end of the RCT. ..
  24. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2007
    ..We will quantify the relations between the hormone and genetic exposures measured in this project and mammographic density (at baseline as well as change in density between baseline and 12 months). ..
  25. Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial Disease
    Kenneth Jay Mukamal; Fiscal Year: 2010
    ..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
  26. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
  27. Role of Microstructure in Nanomechanical Behavior of Bone Tissue
    Marjolein C van der Meulen; Fiscal Year: 2010
    ..Our approach will cross-correlate several microlevel techniques that have not been previously used to characterize bone tissue mechanics. ..
  28. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  29. Treatment of Calcium Nephrolithiasis Sodium Thiosulfate
    John Asplin; Fiscal Year: 2006
    ..New, more effective and better tolerated drugs are needed to reduce the recurrence of kidney stones in these patients. [unreadable] [unreadable] [unreadable]..
  30. Rural Elders' Diabetes Self Management: Development of a Common Sense Model Inven
    Sara A Quandt; Fiscal Year: 2010
    ....
  31. THE FUNCTION OF NEUROTRANSMITTERS IN BONE BIOLOGY
    MATTHEW BLIZIOTES; Fiscal Year: 2009
    ..This research should contribute to new treatment and prevention regimens for osteoporosis and thus have a significant positive impact on the health care of the aging population. ..
  32. Comparison of Aerobic and Resistance Exercise in Older Breast Cancer Survivors
    Kerri Winters Stone; Fiscal Year: 2009
    ..S. "baby boom"population ages. Even so, studies of older women comprise only a small proportion of research, especially exercise research, on improving the lives of cancer survivors. ..
  33. Attenuation of cancellous osteopenia by in vivo loading
    Marjolein van der Meulen; Fiscal Year: 2009
    ..These experiments will provide insights into the mechanisms whereby cancellous bone adapts to mechanical loading and into strategies for inhibiting age-related and postmenopausal bone loss. ..
  34. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  35. Feasibility and Pilot Efficacy of Flash-heated Breastmilk to Reduce Pediatric HIV
    Caroline Chantry; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. Calcium Foods and Bone Health of Adolescent Girls
    Joan Lappe; Fiscal Year: 2007
    ..Lack of a calcium effect would provide support for further research into other methods or concomitant methods of maximizing skeletal development. ..
  37. DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILURE
    William Goodman; Fiscal Year: 2001
    ....
  38. STUDY OF OSTEOPOROTIC FRACTURES
    Jane Cauley; Fiscal Year: 2005
    ....
  39. Sensate Scaffolds for Orthopaedic Tissue Repair
    John Szivek; Fiscal Year: 2005
    ..A system of this type will provide a means of monitoring healing and rehabilitation in patients. ..
  40. Statistical methods for utility of multiple tests
    Ying Lu; Fiscal Year: 2003
    ..based on data from the Study of Osteoporotic Fractures (SOF) and simulation models using cost-effectiveness and population distribution parameters published in literature. ..
  41. Genetic Analysis of Bone Structure and Strength
    Charles Turner; Fiscal Year: 2008
    ..abstract_text> ..
  42. BUILDING BETTER BONES IN CHILDREN
    Babette Zemel; Fiscal Year: 2003
    ..abstract_text> ..
  43. Race differences in hip strength, density and geometry
    Thomas Lang; Fiscal Year: 2004
    ....
  44. RURAL ELDERS: ETHNICITY, FOOD MEANING & DIET MEASUREMENT
    SARA QUANDT; Fiscal Year: 2004
    ..These participants will complete six 24 hour diet recall interviews over a six month period, which will be used to validate the adapted Food Frequency Questionnaire and Meal Pattern Questionnaire. ..
  45. Precise 3D QCT to Monitor Osteoporosis Therapy
    Thomas Lang; Fiscal Year: 2003
    ..Moreover, the high reproducibility of our technique will permit CT centers to offer a method for monitoring therapy effects which will be superior to DXA. ..
  46. Role of Adipose Tissue in Vitamin D Metabolism
    Miriam Blum; Fiscal Year: 2005
    ..The supportive environment and distinguished collaborators that are part of this proposal will provide me with the guidance that I need to pursue my research plans as I make the transition to independent clinical investigator. ..
  47. The Role of Osteocyte Survival in Bone Strength
    Robert Weinstein; Fiscal Year: 2005
    ..The proposed research plan will reveal the role of osteocyte survival in bone strength and how osteocytes achieve this objective. ..
  48. Clinical Utility of Texture Analysis in Osteoporosis
    Tamara Vokes; Fiscal Year: 2006
    ..Following the successful completion of the proposed studies, prospective evaluation of texture analysis will be undertaken in larger populations and in different forms of metabolic bone disease. ..
  49. TESTOSTERONE FOR PREVENTION OF FRACTURE IN MEN
    Anne Kenny; Fiscal Year: 2005
    ....
  50. Animal models for TMJ research: Functional 3-D loading
    KATHERINE RAFFERTY; Fiscal Year: 2003
    ..The data we generate will be used in comparison with finite element predictions of mandibular deformations. ..
  51. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  52. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..Information from these analyses will be used in linear programming to predict how the described changes in nutrient content of milk due to heating would affect the overall dietary needs of the child and the associated costs. ..
  53. Osteoporosis in Hypercalciuric Kidney Stone Formers
    John Asplin; Fiscal Year: 2003
    ..We hope to use the algorithm developed in this research to expand out services to include bone disease management in kidney stone forming patients and their families. ..
  54. VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
    Neil Binkley; Fiscal Year: 2003
    ..abstract_text> ..
  55. MULTIAXIAL STRENGTH BEHAVIOR OF HUMAN TRABECULAR BONE
    Tony M Keaveny; Fiscal Year: 2010
    ..This project should provide substantial insight into the roles of trabecular bone strength and bone quality on osteoporotic fracture risk and treatment and other orthopedic applications. ..
  56. BONE DENSITY AND FOREARM FRACTURES IN INJURED CHILDREN
    Heidi Kalkwarf; Fiscal Year: 2002
    ..Understanding the determinants of this measurement will inform strategies to promote healthy bone and decrease fracture risk in childhood. ..
  57. STRUCTURAL CONSEQUENCES OF POST-YIELD BEHAVIOR OF BONE
    TONY KEAVENY; Fiscal Year: 2003
    ..It is suggested that results should lead, therefore, to improved understanding of vertebral fracture etiology, and may motivate development of new drug treatments. ..
  58. Assessement of Trabecular Bone Strength & Damage
    TONY KEAVENY; Fiscal Year: 2004
    ..abstract_text> ..
  59. Biomechanics of Spine Fracture
    TONY KEAVENY; Fiscal Year: 2007
    ..abstract_text> ..
  60. Laxity and Malalignment in a Large Cohort Study of OA
    Michael Nevitt; Fiscal Year: 2006
    ..abstract_text> ..
  61. Microcomputed Tomography Device (Scanco UCT40)
    Mary Bouxsein; Fiscal Year: 2004
    ..abstract_text> ..
  62. Dietary patterns in relation to adiposity and bone mass in young children
    KAREN WOSJE; Fiscal Year: 2008
    ..This research will inform decisions on dietary recommendations for children. [unreadable] [unreadable] [unreadable] [unreadable]..
  63. REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTIN
    Mary Bouxsein; Fiscal Year: 2008
    ..Information gained from the proposed studies will be instrumental for developing new PTH1R ligands with improved signaling and biologic activity profiles for treatment of osteoporosis and other metabolic bone disorders. ..
  64. Heavy Drinking & Coronary Disease: Acute/Chronic Effects
    Kenneth Mukamal; Fiscal Year: 2006
    ..These results may prove to have important biological, clinical, and public health implications for the care of CHD. ..
  65. Circulating Osteoblast Lineage Cells in Humans
    Sundeep Khosla; Fiscal Year: 2005
    ..abstract_text> ..