Summary: The longest and largest bone of the skeleton, it is situated between the hip and the knee.

Top Publications

  1. ncbi Single-incision technique misses the anatomical femoral anterior cruciate ligament insertion: a cadaver study
    M P Arnold
    Department of Orthopedics, University Hospital, Nijmegen, The Netherlands
    Knee Surg Sports Traumatol Arthrosc 9:194-9. 2001
  2. ncbi The use of micro-CT to evaluate cortical bone geometry and strength in nude rats: correlation with mechanical testing, pQCT and DXA
    Cedo M Bagi
    Comparative Physiology and Medicine, Safety Sciences, Pfizer Inc, Eastern Point Road 8274 1312, Groton, CT 06340, USA
    Bone 38:136-44. 2006
  3. doi Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins
    Enrico Cappellini
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, 1350, Copenhagen, Denmark
    J Proteome Res 11:917-26. 2012
  4. ncbi Changes in the stiffness, strength, and toughness of human cortical bone with age
    P Zioupos
    Department of Biology, University of York, York, UK
    Bone 22:57-66. 1998
  5. doi Anatomical analysis of the anterior cruciate ligament femoral and tibial footprints
    Harehiko Tsukada
    Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, 036 8562, Japan
    J Orthop Sci 13:122-9. 2008
  6. ncbi Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study
    Nunziata Morabito
    Department of Internal Medicine, University of Messina, Italy
    J Bone Miner Res 17:1904-12. 2002
  7. doi Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study
    Roger M D Zebaze
    Department of Medicine, Austin Health, University of Melbourne, Melbourne, Vic, Australia
    Lancet 375:1729-36. 2010
  8. doi The new proximal femoral nail antirotation (PFNA) in daily practice: results of a multicentre clinical study
    R K J Simmermacher
    Department of Surgery, University Medical Center Utrecht, The Netherlands
    Injury 39:932-9. 2008
  9. ncbi Anteromedial portal technique for creating the anterior cruciate ligament femoral tunnel
    Christopher D Harner
    Center for Sports Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 5203, USA
    Arthroscopy 24:113-5. 2008
  10. ncbi Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur
    F Kawana
    Department of Oral Histology, School of Dentistry, Showa University, Shinagawa-ku, Tokyo, Japan
    Anat Rec 264:438-46. 2001

Detail Information

Publications435 found, 100 shown here

  1. ncbi Single-incision technique misses the anatomical femoral anterior cruciate ligament insertion: a cadaver study
    M P Arnold
    Department of Orthopedics, University Hospital, Nijmegen, The Netherlands
    Knee Surg Sports Traumatol Arthrosc 9:194-9. 2001
    We examined the arthroscopic appearance of the anterior cruciate ligament (ACL) attachment site on the femur in five fresh-frozen cadaver knees...
  2. ncbi The use of micro-CT to evaluate cortical bone geometry and strength in nude rats: correlation with mechanical testing, pQCT and DXA
    Cedo M Bagi
    Comparative Physiology and Medicine, Safety Sciences, Pfizer Inc, Eastern Point Road 8274 1312, Groton, CT 06340, USA
    Bone 38:136-44. 2006
    ..Our micro-CT data meet the criteria of providing quick, reproducible and accurate answers regarding cortical bone geometry as a predictor of cortical bone strength...
  3. doi Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins
    Enrico Cappellini
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, 1350, Copenhagen, Denmark
    J Proteome Res 11:917-26. 2012
    ..This approach therefore represents a further step into the ongoing integration of different high-throughput technologies for identification of ancient biomolecules, unleashing the field of paleoproteomics...
  4. ncbi Changes in the stiffness, strength, and toughness of human cortical bone with age
    P Zioupos
    Department of Biology, University of York, York, UK
    Bone 22:57-66. 1998
    ..The macrocrack was preceded by less damage, and once created needed less energy to drive through the tissue (Wf)...
  5. doi Anatomical analysis of the anterior cruciate ligament femoral and tibial footprints
    Harehiko Tsukada
    Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, 036 8562, Japan
    J Orthop Sci 13:122-9. 2008
  6. ncbi Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study
    Nunziata Morabito
    Department of Internal Medicine, University of Messina, Italy
    J Bone Miner Res 17:1904-12. 2002
    ..001). Furthermore, at the end of the experimental period, genistein and HRT significantly increased BMD in the femur (femoral neck: genistein = 3.6 +/- 3%, HRT = 2.4 +/- 2%, placebo = -0.65 +/- 0.1%, and p < 0...
  7. doi Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study
    Roger M D Zebaze
    Department of Medicine, Austin Health, University of Melbourne, Melbourne, Vic, Australia
    Lancet 375:1729-36. 2010
    ..We aimed to re-examine cortical bone as a source of bone loss in the appendicular skeleton...
  8. doi The new proximal femoral nail antirotation (PFNA) in daily practice: results of a multicentre clinical study
    R K J Simmermacher
    Department of Surgery, University Medical Center Utrecht, The Netherlands
    Injury 39:932-9. 2008
  9. ncbi Anteromedial portal technique for creating the anterior cruciate ligament femoral tunnel
    Christopher D Harner
    Center for Sports Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 5203, USA
    Arthroscopy 24:113-5. 2008
    ..This technique is not limited by the choice of graft or fixation and offers the advantage of true parallel screw placement through the same portal as that used for tunnel drilling in the case of interference fixation...
  10. ncbi Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur
    F Kawana
    Department of Oral Histology, School of Dentistry, Showa University, Shinagawa-ku, Tokyo, Japan
    Anat Rec 264:438-46. 2001
    ..Our results suggest that EMD possesses an osteo-promotive effect on bone and medullary regeneration during wound healing of injured long bones...
  11. pmc A crucial role for thiol antioxidants in estrogen-deficiency bone loss
    Jenny M Lean
    Department of Cellular Pathology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom
    J Clin Invest 112:915-23. 2003
    ..This directly sensitizes osteoclasts to osteoclastogenic signals and entrains ROS-enhanced expression of cytokines that promote osteoclastic bone resorption...
  12. ncbi Morphological study of the proximal femur: a new method of geometrical assessment using 3-dimensional reverse engineering
    Banchong Mahaisavariya
    Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Med Eng Phys 24:617-22. 2002
    ..technique to obtain and analyse the three-dimensional inner and outer geometry of the proximal cadaveric femur. Three-dimensional models were reconstructed from the computerized tomography images and approximated with 2D and ..
  13. doi Porous CaP/silk composite scaffolds to repair femur defects in an osteoporotic model
    Ning Cheng
    State Key Laboratory Breeding Base of Basic Science of Stomatology Hubei MOST and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, People s Republic of China
    J Mater Sci Mater Med 24:1963-75. 2013
  14. ncbi Surface engineering of titanium by collagen immobilization. Surface characterization and in vitro and in vivo studies
    M Morra
    Nobil Bio Ricerche, Str S Rocco 36, 14018 Villafranca d Asti, Italy
    Biomaterials 24:4639-54. 2003
    ..Importantly, implants in rabbit femur show a significant increase of bone growth and bone-to-implant contact in the case of the collagen modified ..
  15. doi Internal forces and moments in the femur of the rat during gait
    Tim Wehner
    Institute of Orthopaedic Research and Biomechanics, Ulm University, Helmholtzstrasse 14, Ulm, Germany
    J Biomech 43:2473-9. 2010
    ..The greatest internal moment (up to 13.8 bodyweight times millimeter) acted in the sagittal plane of the femur. The validity of the model was corroborated by comparing the estimated strains caused by the calculated loads on ..
  16. ncbi Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat
    Giuliana Silvestrini
    Department of Experimental Medicine and Pathology, Sezione di Anatomia Patologica, Policlinico Umberto I, Viale Regina Elena, 324, 00161, Roma, Italy
    J Mol Histol 36:59-67. 2005
    ..The co-expression of OPG and RANKL in the same bone cell types confirms their strictly coupled action in the regulation of bone metabolism...
  17. doi Bone mineral content is positively correlated to n-3 fatty acids in the femur of growing rats
    Yong Li
    Lipid Chemistry and Molecular Biology Laboratory, 745 Agriculture Mall Drive, Purdue University, West Lafayette, IN 47907, USA
    Br J Nutr 104:674-85. 2010
    ..The rats were later weaned onto similar pelleted diets. At adulthood, the rats were euthanised and bones (femur, tibia, and lumbar vertebrae) collected for tissue fatty acid analysis and bone mineral density (BMD) ..
  18. pmc Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading
    Shane A Lloyd
    Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, Penn State College of Medicine, Hershey, PA 17033, USA
    J Bone Miner Res 27:2359-72. 2012
    ..rate, mineralizing surface, and mineral apposition rate at both the periosteal and endocortical surfaces of the femur after unloading of WT mice...
  19. ncbi Anabolism. Low mechanical signals strengthen long bones
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794 2580, USA
    Nature 412:603-4. 2001
    ..of very-low-magnitude, high-frequency vibration, the density of the spongy (trabecular) bone in the proximal femur is significantly increased (by 34.2%) compared to controls...
  20. ncbi Bone development and age-related bone loss in male C57BL/6J mice
    Virginia L Ferguson
    BioServe Space Technologies, University of Colorado, Boulder, CO 80309, USA
    Bone 33:387-98. 2003
    ..Male C57BL/6J mice were aged in our colony between 4 and 104 weeks (n=9-15/group). The right femur and humeri were measured for length and subjected to mechanical testing (3-point flexure) and compositional ..
  21. doi Femur EPA and DHA are correlated with femur biomechanical strength in young fat-1 mice
    Beatrice Y Y Lau
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    J Nutr Biochem 20:453-61. 2009
    ..b>Femur bone mineral content (BMC) and density were determined by dual-energy X-ray absorptiometry, and biomechanical ..
  22. doi Structural properties of fourth-generation composite femurs and tibias
    Anneliese D Heiner
    Biomechanics Laboratory, Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn, Iowa City, IA 52242, USA
    J Biomech 41:3282-4. 2008
    ..axial, and torsional loading, and the longitudinal strain distribution along the proximal-medial diaphysis of the femur was also determined...
  23. doi New method for Raman investigation of the orientation of collagen fibrils and crystallites in the Haversian system of bone
    Guillaume Falgayrac
    Univ Lille Nord de France, F 59000 Lille, France
    Appl Spectrosc 64:775-80. 2010
    ..This work highlights the interest of Raman spectroscopy for the multiscale investigation of bone structure...
  24. pmc Association of hip strength estimates by finite-element analysis with fractures in women and men
    Shreyasee Amin
    Division of Rheumatology, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 26:1593-600. 2011
    ..However, it is uncertain whether the site-specific detail included in FEA-estimated proximal femur (hip) strength can determine fracture risk at sites with different biomechanical characteristics...
  25. doi The proximal femur nail antirotation: an identifiable improvement in the treatment of unstable pertrochanteric fractures?
    Tjibbe J Gardenbroek
    Department of Surgery, St Antonius Hospital, Nieuwegein, The Netherlands
    J Trauma 71:169-74. 2011
    ..The Proximal Femur Nail Antirotation (PFNA) has been designed to address these...
  26. doi Anterior cruciate ligament reconstruction: can anatomic femoral placement be achieved with a transtibial technique?
    Dana P Piasecki
    OrthoCarolina, Sports and Complex Knee Center, Charlotte, NC 28207, USA
    Am J Sports Med 39:1306-15. 2011
    ..Recent reports have suggested that a traditional transtibial technique cannot practically accomplish an anatomic anterior cruciate ligament (ACL) reconstruction...
  27. doi Callus features of regenerate fracture cases in femoral lengthening in achondroplasia
    Kamlesh N Devmurari
    Institute for Rare Diseases and Department of Orthopedic Surgery, Korea University Medical College, Guro Hospital, Seoul, Korea
    Skeletal Radiol 39:897-903. 2010
    ..We studied the callus features seen in cases of regenerate fracture in femoral lengthening using a monolateral fixator in achondroplasia to determine whether callus types and shapes can predict the probability of callus fracture...
  28. ncbi The compatibility of ceramic bone graft substitutes as allograft extenders for use in impaction grafting of the femur
    A W Blom
    Department of Orthopaedic Surgery, Bristol Royal Infirmary, Bristol, England, UK
    J Bone Joint Surg Br 87:421-5. 2005
    This study investigates the use of porous biphasic ceramics as graft extenders in impaction grafting of the femur during revision hip surgery. Impaction grafting of the femur was performed in four groups of sheep...
  29. doi Magnesium alloys for temporary implants in osteosynthesis: in vivo studies of their degradation and interaction with bone
    Tanja Kraus
    Department of Pediatric Orthopedics, Medical University Graz, 8036 Graz, Austria
    Acta Biomater 8:1230-8. 2012
    ..Online μCT monitoring is shown to be suitable for evaluating materials degradation and bone response in vivo, providing continuous information on the implant and tissue performance in the same living animal...
  30. doi Drilled hole defects in mouse femur as models of intramembranous cortical and cancellous bone regeneration
    Laurent Monfoulet
    Universite Victor Segalen Bordeaux 2, Bordeaux 33076, France
    Calcif Tissue Int 86:72-81. 2010
    ..of cortical and cancellous bone regeneration, we compared the kinetics and patterns of bone healing in mouse femur using two defect protocols. The first protocol consisted of a 0...
  31. ncbi Tibio-femoral movement in the living knee. A study of weight bearing and non-weight bearing knee kinematics using 'interventional' MRI
    P Johal
    Department of Orthopaedics, St Mary s Hospital, W2 1NY London, UK
    J Biomech 38:269-76. 2005
    ..Thus, during flexion of the knee to 120 degrees , the femur rotated externally through an angle of 20 degrees ...
  32. doi Outcome of short proximal femoral nail antirotation and dynamic hip screw for fixation of unstable trochanteric fractures. A randomised prospective comparative trial
    Bhavuk Garg
    Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India
    Hip Int 21:531-6. 2011
    ..Eighty one patients with unstable fracture of the proximal part of the femur were randomised, at the time of admission, for fixation with either a short PFNA (n=42) or DHS (n= 39)...
  33. pmc The relationship between fractures and DXA measures of BMD in the distal femur of children and adolescents with cerebral palsy or muscular dystrophy
    Richard C Henderson
    Department of Orthopaedics, University of North Carolina, Chapel Hill, NC 27599 7055, USA
    J Bone Miner Res 25:520-6. 2010
    ..hip dysplasia, and metallic implants often prevent reliable measures of bone mineral density (BMD) in the proximal femur and lumbar spine, where BMD is commonly measured...
  34. doi Genistein aglycone effect on bone loss is not enhanced by supplemental calcium and vitamin D3: a dose ranging experimental study
    A Bitto
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Italy
    Phytomedicine 18:879-86. 2011
    ..This observation has implications regarding the use of calcium and vitamin D(3) supplementation...
  35. doi Medium to long-term results after reconstruction of bone defects at the knee with tumor endoprostheses
    S Kinkel
    Department of Orthopaedics, University of Heidelberg, 69118 Heidelberg, Germany
    J Surg Oncol 101:166-9. 2010
    ..Limb salvage and reconstruction with tumor endoprostheses is considered as therapeutic standard in the treatment of bone defects at the knee. Few studies report long-term results so far...
  36. doi Validation of a new technique to determine midbundle femoral tunnel position in anterior cruciate ligament reconstruction using 3-dimensional computed tomography analysis
    Jonathan H Bird
    Department of Trauma and Orthopaedic Surgery, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, England
    Arthroscopy 27:1259-67. 2011
    ..The purpose of this study was to investigate and report on a new intraoperative measuring technique to place the anterior cruciate ligament (ACL) femoral tunnel in the center of the native ACL femoral insertion site...
  37. doi Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties
    Maximilien Vanleene
    Department of Bioengineering, Imperial College, London, UK
    Blood 117:1053-60. 2011
    ..In conclusion, expression of normal collagen from mature osteoblast of donor origin significantly decreased bone brittleness by improving the mechanical integrity of the bone at the molecular, tissue, and whole bone levels...
  38. doi A systematic review of the femoral origin and tibial insertion morphology of the ACL
    Sebastian Kopf
    Department of Orthopaedic Surgery, University of Pittsburgh, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Knee Surg Sports Traumatol Arthrosc 17:213-9. 2009
    ..This study is a systematic review of the morphology of the ACL femoral origin and tibial insertion as reported in the literature...
  39. pmc Effect of local zoledronate on implant osseointegration in a rat model
    David A Back
    Department of Orthopedics and Traumatology, German Armed Forces Hospital Berlin, Berlin, Germany
    BMC Musculoskelet Disord 13:42. 2012
    ..Aim of this study was to investigate the release kinetics of the chosen coating and the effect of different concentrations of ZOL locally released from this coating on the osseointegration of implants...
  40. ncbi Computer-assisted knee arthroplasty versus a conventional jig-based technique. A randomised, prospective trial
    S K Chauhan
    Royal Perth Hospital, Perth, Western Australia
    J Bone Joint Surg Br 86:372-7. 2004
    ..011) and femorotibial mismatch (p = 0.037). Standing alignment was also improved (p = 0.004) and blood loss was less (p = 0.0001). Computer-assisted surgery took longer with a mean increase of 13 minutes (p = 0.0001)...
  41. ncbi Knee stability and graft function following anterior cruciate ligament reconstruction: Comparison between 11 o'clock and 10 o'clock femoral tunnel placement. 2002 Richard O'Connor Award paper
    John C Loh
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Arthroscopy 19:297-304. 2003
    ..Type of Study: Biomechanical experiment using human cadaveric specimens...
  42. ncbi Tibio-femoral loading during human gait and stair climbing
    William R Taylor
    Research Laboratory, Trauma and Reconstructive Surgery, Charite, Humboldt University of Berlin, Campus Virchow Clinic, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Orthop Res 22:625-32. 2004
    ..Clinically, the conditions that produce these larger contact forces should be avoided during post-operative rehabilitation...
  43. pmc 3066 consecutive Gamma Nails. 12 years experience at a single centre
    Alicja J Bojan
    Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    BMC Musculoskelet Disord 11:133. 2010
    ..Through access to a uniquely large patient data base available, which is available for analysis of trochanteric fractures; we have been able to evaluate the performance of the Gamma Nail over a twelve year period...
  44. doi Numerical modeling of bone tissue adaptation--a hierarchical approach for bone apparent density and trabecular structure
    P G Coelho
    Mechanical and Industrial Engineering Department, FCT UNL, Portugal
    J Biomech 42:830-7. 2009
    ..In order to show the potential of the model, a three-dimensional example of the proximal femur illustrates the distribution of bone apparent density as well as microstructural designs characterizing both ..
  45. doi A prospective, randomized clinical study of osteochondral autologous transplantation versus microfracture for the treatment of osteochondritis dissecans in the knee joint in children
    Rimtautas Gudas
    Kaunas University of Medicine, Kaunas, Lithuania
    J Pediatr Orthop 29:741-8. 2009
  46. doi A human knee joint model considering fluid pressure and fiber orientation in cartilages and menisci
    K B Gu
    Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive, NW, Calgary, Alberta, Canada T2N 1N4
    Med Eng Phys 33:497-503. 2011
    ..The present study indicates the necessity of implementing the fluid pressure and anisotropic fibril reinforcement in articular cartilage for a more accurate understanding of the mechanics of the knee...
  47. pmc Vitamin D receptor activators can protect against vascular calcification
    Suresh Mathew
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Nephrol 19:1509-19. 2008
    ..We conclude that low, clinically relevant dosages of calcitriol and paricalcitol may protect against CKD-stimulated vascular calcification...
  48. ncbi Maturational disturbance of chondrocytes in Cbfa1-deficient mice
    M Inada
    Department of Medicine III, Osaka University Medical School, Japan
    Dev Dyn 214:279-90. 1999
    ..The expression of PTH/PTHrP receptor, Indian hedgehog, type X collagen, and BMP6 was not detected in humerus and femur, indicating that chondrocyte differentiation was blocked before prehypertrophic chondrocytes...
  49. pmc Improvement of trochanteric bone quality in an osteoporosis model after short-term treatment with parathyroid hormone: a new mechanical test for trochanteric region of rat femur
    M Tezval
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Goettingen, Germany
    Osteoporos Int 21:251-61. 2010
    We have examined the changes induced in the trochanteric region of femur of ovariectomized rat after administration of estradiol and parathyroid hormone...
  50. ncbi Results on total hip arthroplasties with femoral shortening for Crowe's group IV dislocated hips
    Hiroyuki Makita
    Department of Orthpaedic Surgery, Yokohama City University School of Medicine, Yokohama, Japan
    J Arthroplasty 22:32-8. 2007
    ..One hip had to be revised 8 years after surgery because of aseptic loosening of the stem. Our study shows that total hip arthroplasty, incorporating step-cut femoral shortening, provides acceptable results for completely dislocated hip...
  51. ncbi Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD
    Vicente Gilsanz
    Department of Radiology, Childrens Hospital of Los Angeles, University of Southern California, Keck School of Medicine, Los Angeles, California 90027, USA
    J Bone Miner Res 21:1464-74. 2006
    ..Twelve months of this noninvasive signal, induced as whole body vibration for at least 2 minutes each day, increased bone and muscle mass in the axial skeleton and lower extremities compared with controls...
  52. ncbi Determination of orthotropic bone elastic constants using FEA and modal analysis
    W R Taylor
    Department of Mechanical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Biomech 35:767-73. 2002
    ..This study has thereby produced an orthotropic finite element model of a human femur. More importantly, however, is the implication that it is possible to create a valid FE model by simply comparing ..
  53. ncbi A finite element model of the human knee joint for the study of tibio-femoral contact
    Tammy L Haut Donahue
    Department of Mechanical Engineering, Michigan Technological University, Houghton 49931, USA
    J Biomech Eng 124:273-80. 2002
    ..The model included both the cortical and trabecular bone of the femur and tibia, articular cartilage of the femoral condyles and tibial plateau, both the medial and lateral menisci ..
  54. ncbi Repair of osteochondral defects with biphasic cartilage-calcium polyphosphate constructs in a sheep model
    R A Kandel
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, Canada M5G 1X5
    Biomaterials 27:4120-31. 2006
    ..The results indicate that further study of this treatment approach is warranted to attempt to overcome the technical surgical difficulties identified in this study...
  55. doi A new high-resolution computed tomography (CT) segmentation method for trabecular bone architectural analysis
    Heike Scherf
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Am J Phys Anthropol 140:39-51. 2009
    ..Tests with data of extant and fossil material demonstrate the superior quality of RCA compared with conventional thresholding procedures, and emphasize the need for careful consideration of optimal CT scanning parameters...
  56. ncbi Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging
    Miika T Nieminen
    Department of Anatomy, University of Kuopio, Kuopio, Finland
    J Biomech 37:321-8. 2004
    ..The results are encouraging with respect to functional imaging of cartilage, although in vivo applicability may be limited by the inferior resolution of clinical MRI instruments...
  57. ncbi Internodes can nearly double in length with gradual elongation of the adult rat sciatic nerve
    Ichiro Abe
    Department of Orthopedic Surgery, University of Tsukuba, 1 1 1 Tennodai, Tsukuba shi, Ibaraki 305 8575, Japan
    J Orthop Res 22:571-7. 2004
    ..e., intercalation of a segment). Only 0.8% of axons showed degeneration in the group with 70 mm of elongation. We concluded that adult rat sciatic nerve can adapt itself to leg lengthening procedure with even doubling internodal length...
  58. ncbi The attachments of the anteromedial and posterolateral fibre bundles of the anterior cruciate ligament. Part 2: femoral attachment
    Andrew Edwards
    Department of Mechanical Engineering, Imperial College London, London, SW7 2AZ, UK
    Knee Surg Sports Traumatol Arthrosc 16:29-36. 2008
    ..0% (40-70) in a high-low direction. The attachment was oriented at 37 degrees to the femoral long axis. The results from this study could be used to guide ACL reconstruction techniques...
  59. pmc Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation
    Jesper Hjortnaes
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA
    Eur Heart J 31:1975-84. 2010
    ..We hypothesize that cardiovascular calcification progresses with inflammation and inversely correlates with bone tissue mineral density (TMD)...
  60. ncbi Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model
    Borhane H Fellah
    INSERM U791, Laboratory for Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery, 1 Place Alexis Ricordeau, Nantes, France
    Biomaterials 29:1177-88. 2008
    ..4+/-3.7% initially to 1.7+/-1.2% at 12 weeks). This study shows that synthetic bone substitutes may have superior stability and osteogenic properties than autologous bone grafts in critical-sized bone defects...
  61. ncbi On the influence of soft tissue coverage in the determination of bone kinematics using skin markers
    William R Taylor
    Center for Musculoskeletal Surgery, Charite University Medicine Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Orthop Res 23:726-34. 2005
    ..5 mm for the femur, 2.8 for the tibia and 2.0 for the metatarsus...
  62. ncbi Double-bundle versus single-bundle anterior cruciate ligament reconstruction: a prospective, randomize clinical study
    Timo Jarvela
    Department of Orthopaedics and Traumatology, Hatanpaa Hospital, Tampere, Finland
    Knee Surg Sports Traumatol Arthrosc 15:500-7. 2007
    ..In addition, knee scores were equal at the follow-up, and all the results were significantly better at the follow-up than preoperatively, in both groups...
  63. ncbi Osseous landmarks of the femoral attachment of the anterior cruciate ligament: an anatomic study
    Mario Ferretti
    Department of Orthopaedic Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Arthroscopy 23:1218-25. 2007
    ..Anatomic tunnel placement is critical to the success of anterior cruciate ligament (ACL) reconstruction. The purpose of this study was to determine qualitatively and quantitatively the osseous landmarks of femoral attachment of the ACL...
  64. ncbi Age-related changes in the collagen network and toughness of bone
    X Wang
    Department of Mechanical Engineering, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Bone 31:1-7. 2002
    ..Also, the results suggest that nonenzymatic glycation may be an important contributing factor causing changes in collagen and, consequently, leading to the age-related deterioration of bone quality...
  65. pmc Reconstruction technique affects femoral tunnel placement in ACL reconstruction
    Maria K Kaseta
    Division of Orthopaedics, Sports Medicine Center, Duke University Medical Center, Durham, NC 27710, USA
    Clin Orthop Relat Res 466:1467-74. 2008
    Grafts placed too anteriorly on the femur are reportedly a common cause of failure in anterior cruciate ligament reconstruction. Some studies suggest more anatomic femoral tunnel placement improves kinematics...
  66. ncbi In vivo evaluation of plasma-sprayed wollastonite coating
    Weichang Xue
    Plasma Spray Laboratory, Shanghai Institute of Ceramics, Chinese Academy of Science, 1295 Dingxi Road, Shanghai 200050, People s Republic of China
    Biomaterials 26:3455-60. 2005
    ..The test in marrow indicated that wollastonite coatings could induce new bone formation on their surface showing good bone inductivity property...
  67. doi Femoral bone tunnel placement using the transtibial tunnel or the anteromedial portal in ACL reconstruction: a radiographic evaluation
    Jens Dargel
    Institute II for Anatomy, University of Cologne, Joseph Stelzmann Strasse 9, Cologne 50931, Germany
    Knee Surg Sports Traumatol Arthrosc 17:220-7. 2009
    ..Further studies may evaluate if there are any clinical advantages using the anteromedial portal technique...
  68. doi Anteromedial portal technique for the anterior cruciate ligament femoral socket: pitfalls and solutions
    James H Lubowitz
    Taos Orthopaedic Institute Research Foundation, Taos, New Mexico 87571, USA
    Arthroscopy 25:95-101. 2009
    ..The purpose of this technical note is to describe tips and pearls for surgeons contemplating the transition to the AM portal technique for the ACL femoral socket...
  69. pmc Low-frequency vibratory exercise reduces the risk of bone fracture more than walking: a randomized controlled trial
    Narcis Gusi
    Faculty of Sports Sciences, University of Extremadura, Caceres, Spain
    BMC Musculoskelet Disord 7:92. 2006
    ..The aim was to compare the effects of WBV using a reciprocating platform at frequencies lower than 20 Hz and a walking-based exercise programme on BMD and balance in post-menopausal women...
  70. ncbi THA loading arising from increased femoral anteversion and offset may lead to critical cement stresses
    Ralf U Kleemann
    Trauma and Reconstructive Surgery, Charite, Campus Virchow Clinic, Humboldt University of Berlin, Augustenburger Platz 1, D 13353, Berlin, Germany
    J Orthop Res 21:767-74. 2003
    ..is hypothesised that variations in implant anteversion and offset lead to changes in the loading of the proximal femur, causing critical conditions to both the bone and cement...
  71. ncbi Does the position of the femoral tunnel affect the laxity or clinical outcome of the anterior cruciate ligament-reconstructed knee? A clinical, prospective, randomized, double-blind study
    Claus Fink Jepsen
    Randers Central Hospital, Randers, Denmark
    Arthroscopy 23:1326-33. 2007
  72. ncbi The performance of poly-epsilon-caprolactone scaffolds in a rabbit femur model with and without autologous stromal cells and BMP4
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Biomaterials 28:3101-9. 2007
    ..Finally, the BMP4-expressing BMSCs strongly favoured osteoinductivity of cellular constructs, as demonstrated by a more extensive bone/scaffold contact...
  73. ncbi The fixation strength of six hamstring tendon graft fixation devices in anterior cruciate ligament reconstruction. Part I: femoral site
    Petteri Kousa
    Department of Surgery, University of Tampere and Tampere University Hospital, Tampere, Finland
    Am J Sports Med 31:174-81. 2003
    ..Strength of graft fixation is the weakest link in anterior cruciate ligament reconstruction...
  74. ncbi Trochleoplasty in dysplastic knee trochlea
    R Verdonk
    Department of Orthopaedic Surgery and Physical Medicine, Ghent University Hospital, Belgium
    Knee Surg Sports Traumatol Arthrosc 13:529-33. 2005
    ..This technique might be a valuable alternative in cases of frank trochlear dysplasia associated with persistent retropatellar pain or recurrent patellar dislocations...
  75. ncbi A new electrochemically graded hydroxyapatite coating for osteosynthetic implants promotes implant osteointegration in a rat model
    G Schmidmaier
    Department of Trauma and Reconstructive Surgery, Charite, Humboldt University of Berlin, Germany
    J Biomed Mater Res 63:168-72. 2002
    ..The results demonstrate that the HAP coating promotes implant osteointegration in a rat model...
  76. ncbi Femoral lengthening over an intramedullary nail using the external fixator: risk of infection and knee problems in 22 patients with a follow-up of 2 years or more
    Hae Ryong Song
    Korea University Medical Center, Kuro Hospital, Seoul
    Acta Orthop 76:245-52. 2005
    ..The time for femoral lengthening is shortened if external fixation is combined with intramedullary nailing. However, several complications have been reported with this procedure...
  77. ncbi Broken bioabsorbable femoral cross-pin after anterior cruciate ligament reconstruction with hamstring tendon graft: a case report
    Ilkyu Han
    Department of Orthopedic Surgery, Seoul National University College of Medicine, Korea
    Am J Sports Med 33:1742-5. 2005
  78. ncbi Does microdamage accumulation affect the mechanical properties of bone?
    D B Burr
    Department of Anatomy, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biomech 31:337-45. 1998
    ..We also conclude that damage accumulates more rapidly in tensile cortices, but crack growth is greater in compressive cortices...
  79. ncbi Influence of nonenzymatic glycation on biomechanical properties of cortical bone
    D Vashishth
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180
    Bone 28:195-201. 2001
  80. ncbi Comparison of three-point bending test and peripheral quantitative computed tomography analysis in the evaluation of the strength of mouse femur and tibia
    T Jamsa
    Technical Services Unit and Biomedical Engineering Program, University of Oulu, Finland
    Bone 23:155-61. 1998
    ..9%-18.1% for SSI. CSMI and CSA were found to be the best explanatory variables for the breaking force of femur and tibia, respectively, while CSA and CSMI were the best predictors for the elastic modulus of femur and tibia, ..
  81. ncbi Trabecular bone modulus-density relationships depend on anatomic site
    Elise F Morgan
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, 6175 Etcheverry Hall, Berkeley, CA 94720 1740, USA
    J Biomech 36:897-904. 2003
    ..15), suggesting that the site-specificity in apparent modulus-density relationships may be attributed to differences in architecture...
  82. ncbi Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
    R M Neer
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 344:1434-41. 2001
    ..The 40-microg dose increased bone mineral density more than the 20-microg dose but had similar effects on the risk of fracture and was more likely to have side effects...
  83. ncbi Prevention of fracture healing in rats by an inhibitor of angiogenesis
    M R Hausman
    Leni and Peter W. May Department of Orthopedics, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
    Bone 29:560-4. 2001
    ..Finally, the data raise the possibility that impairment of fracture healing may be an adverse effect of clinical treatments with antiangiogenic drugs...
  84. ncbi Morphology of anterior cruciate ligament attachments for anatomic reconstruction: a cadaveric dissection and radiographic study
    Philippe Colombet
    Department d Anatomie, Universite de Tours
    Arthroscopy 22:984-92. 2006
    ..To define the positions of the attachments of the anteromedial (AM) and posterolateral (PL) bundles of the anterior cruciate ligament (ACL)...
  85. ncbi Transmissibility of 15-hertz to 35-hertz vibrations to the human hip and lumbar spine: determining the physiologic feasibility of delivering low-level anabolic mechanical stimuli to skeletal regions at greatest risk of fracture because of osteoporosis
    Clinton Rubin
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Spine (Phila Pa 1976) 28:2621-7. 2003
    Experiments were undertaken to determine the degree to which high-frequency (15-35 Hz) ground-based, whole-body vibration are transmitted to the proximal femur and lumbar vertebrae of the standing human.
  86. pmc Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns
    Hope Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Man
    CMAJ 172:757-61. 2005
    ..Vitamin D is required for normal bone growth and mineralization. We sought to determine whether vitamin D deficiency at birth is associated with bone mineral content (BMC) of Canadian infants...
  87. doi How precise can bony landmarks be determined on a CT scan of the knee?
    J Victor
    AZ St Lucas, Brugge, Belgium
    Knee 16:358-65. 2009
    ..28 degrees). In the horizontal plane the lowest variability was observed for the posterior condylar line of the femur (intra-observer 0.17 degrees and inter-observer 0.78 degrees) and for the transverse axis (respectively 1...
  88. ncbi Raman imaging of two orthogonal planes within cortical bone
    M Kazanci
    Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14424 Potsdam, Germany, and Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK, Vienna, Austria
    Bone 41:456-61. 2007
    ..The present study provides fresh insights into the organization of a lamellar bone tissue from two orthogonal orientations...
  89. ncbi Alignments and clinical results in conventional and navigated total knee arthroplasty
    A Ensini
    Department of Orthopaedic Surgery, University of Bologna, Italy
    Clin Orthop Relat Res 457:156-62. 2007
    ..resection planes showed navigated surgeries result in more accurate alignments than conventional surgeries for the femur: in the frontal plane, 0.1 degrees +/- 0.9 degrees and 0.7 degrees +/- 1...
  90. ncbi Femoral lengthening over an intramedullary nail. A matched-case comparison with Ilizarov femoral lengthening
    D Paley
    Maryland Center for Limb Lengthening and Reconstruction, Baltimore 21207, USA
    J Bone Joint Surg Am 79:1464-80. 1997
    ..37). The advantages of lengthening over an intramedullary nail include a decrease in the duration of external fixation, protection against refracture, and earlier rehabilitation...
  91. ncbi Varying femoral tunnels between the anatomical footprint and isometric positions: effect on kinematics of the anterior cruciate ligament-reconstructed knee
    Volker Musahl
    Department of Orthopaedic Surgery, University of Pittsburgh, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Am J Sports Med 33:712-8. 2005
    ..Knee kinematics and in situ forces resulting from anterior cruciate ligament reconstructions with 2 femoral tunnel positions were evaluated...
  92. ncbi The premature failure of the Charnley Elite-Plus stem: a confirmation of RSA predictions
    J Hauptfleisch
    Oxford Orthopaedic Engineering Centre The Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK
    J Bone Joint Surg Br 88:179-83. 2006
    ..Our findings have also shown that rapid posterior head migration is predictive of premature loosening and a better predictor than subsidence...
  93. ncbi Effects of ionizing radiation on the mechanical properties of human bone
    J D Currey
    Department of Biology, University of York, England, U K
    J Orthop Res 15:111-7. 1997
  94. pmc Serum metabolite profiles and target tissue gene expression define the effect of cholecalciferol intake on calcium metabolism in rats and mice
    James C Fleet
    Department of Foods and Nutrition and the Interdepartmental Nutrition Program, Purdue University, West Lafayette, IN 47907 2059, USA
    J Nutr 138:1114-20. 2008
    ..Our data show that modeling human VD3 status requires lower intake than the current NRC rodent requirement (1000-IU/kg diet). Also, although rodents are very tolerant of high-VD3 intake, it cannot compensate for moderate Ca restriction...
  95. ncbi Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin
    A Mizuno
    Research Institute of Life Science, Snow Brand Milk Products, CO, Ltd, Tochigi, Japan
    Biochem Biophys Res Commun 247:610-5. 1998
    ..These results demonstrate that OCIF/OPG is a key factor acting as a negative regulator against osteoclastogenesis. The OCIF/OPG knockout mice provide the first animal model for osteoporosis without other obvious abnormalities...
  96. pmc Biochemical and genetic analysis of ANK in arthritis and bone disease
    Kyle A Gurley
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 79:1017-29. 2006
    ..The combination of biochemical and genetic analyses presented here provides insight into how mutations in ANKH cause human skeletal disease...
  97. ncbi Bone histology indicates insular dwarfism in a new Late Jurassic sauropod dinosaur
    P Martin Sander
    Institute of Paleontology, University of Bonn, Nussallee 8, D 53115 Bonn, Germany
    Nature 441:739-41. 2006
    ..Comparison with the long-bone histology of large-bodied sauropods suggests that the island dwarf species evolved through a decrease in growth rate from its larger ancestor...
  98. doi Probabilistic finite element analysis of the uncemented hip replacement--effect of femur characteristics and implant design geometry
    Carolina Dopico-González
    Bioengineering Research Group, School of Engineering Sciences, University of Southampton, United Kingdom
    J Biomech 43:512-20. 2010
    ..The results varied depending on the femur, the implant design and the interface conditions...
  99. doi Anterior cruciate ligament tunnel position measurement reliability on 3-dimensional reconstructed computed tomography
    Pisit Lertwanich
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Arthroscopy 27:391-8. 2011
    ..The purpose of this study was to evaluate intraobserver and interobserver reliability of anterior cruciate ligament tunnel location measurement by use of 3-dimensional reconstructed computed tomography (CT)...
  100. doi Growth disturbance after lengthening of the lower limb and quantitative assessment of physeal closure in skeletally immature patients with achondroplasia
    S H Song
    Korea University Medical Center, Guro Hospital, Institute for Rare Diseases and Department of Orthopaedic Surgery, 80 Guro dong, Guro Gu, Seoul 152 703, Korea
    J Bone Joint Surg Br 94:556-63. 2012
    ..2 cm (59.5%) in Group 1a, and 9.0 cm (58.2%) in the tibia and 10.2 cm (54.3%) in the femur in Group 1b. The mean follow-up was 9.3 years (8.6 to 10.3)...
  101. pmc Age-related changes in cortical porosity of the midshaft of the human femur
    S A Feik
    School of Dental Science, University of Melbourne, Victoria, Australia
    J Anat 191:407-16. 1997
    ..The femoral midshaft resembles other skeletal sites in that age changes in TSPP are more marked in females than males...

Research Grants65

  1. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    ..mice expressing SIRT1 show enhanced deacetylation of FOXO1 in bone, increased bone mass in the spine and femur and increased osteoblast but decreased osteoclast numbers...
  2. Prevention of age-associated musculoskeletal loss by n-3 fatty acids
    Md Mizanur Rahman; Fiscal Year: 2013
    ..bone formation and bone resorption activities to determine bone remodeling status;analyze material testing of femur and biomechanical tests of vertebrae to determine bone strength and toughness against bone fracture...
  3. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ..bone loss in patients receiving radiation therapy for gynecological tumors: We observed a 14% decline in proximal femur bone mineral content (BMC)...
  4. Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    ..pregnancy using ultrasound measures of biparietal diameter, occipital frontal diameter, head circumference, femur length, and abdominal circumference taken at approximately 18-20, 28- 30 and 35-36 weeks gestation;(3) examining ..
  5. Effect of botulinum toxin plus vibration on bone in children with cerebral palsy
    Christopher M Modlesky; Fiscal Year: 2012
    ..the accretion of bone mineral content (BMC) and the development of trabecular and cortical bone structure in the femur and tibia through alterations in bone turnover and that the Botox-induced deterioration of bone can be mitigated ..
  6. Angiogenesis and Long-term Bone and Joint Allotransplant Survival
    Allen T Bishop; Fiscal Year: 2012
    ..Growth factors are delivered, encapsulated within biodegradable microspheres placed within the transplanted femur. Angiogenesis is measured at two time points by quantifying capillary density with microangiography and bone blood ..
  7. Early effects of PTH on the proximal femur
    Felicia Cosman; Fiscal Year: 2013
    ..by finite element analysis at the hip, nothing is known about the mechanism of the effect of TPTD on the proximal femur. While BMD changes are smaller and slower in the hip in response to TPTD than in the spine, it is possible that ..
  8. Genetics of Bone Structure and Metabolism
    Michael C Mahaney; Fiscal Year: 2013
    ..traits including bone ultrasound attenuation of the calcaneous, bone mineral densities in 3 regions (proximal femur, lumbar spine, and forearm) assessed using dual-energy X-ray absorptiometry, and 12 biomarkers related to bone ..
  9. 2012 AAOS Femoroacetabular Impingement Research Symposium
    John C Clohisy; Fiscal Year: 2011
    ..FAI is characterized by structural deformities of the proximal femur and acetabulum that produce abnormal repetitive abutment along the acetabular rim resulting in excessive loading, ..
  10. Air pollution and fetal growth in China
    Yawei Zhang; Fiscal Year: 2013
    ..for each subject) of biparietal diameter (BPD), occipital frontal diameter (OFD), head circumference (HC), femur length (FL), and abdominal circumference (AC) at 13th, 26th, and 35th week gestation...
  11. Sex-specific movement differences in young adults with and without hip pain
    CARA L LEWIS; Fiscal Year: 2013
    ..In FAI, hip pain occurs in the presence of a structural abnormality of the acetabulum or femur which results in early contact between the bones during hip flexion and internal rotation...
  12. Effect of Intense Multi-Modal Training on Bone Mineral Density, Bone Biomarkers,
    Todd Anthony Astorino; Fiscal Year: 2013
    ..Bone loss is rapid in the initial six months post-injury and is greatest in sites such as the tibia and femur that typically receive skeletal loading...
    Ping Men; Fiscal Year: 2012
    ..g. femur, humerus, mandible, tibia and vertebra) in the animals will be collected after treatment and the treatment ..
  14. Treatment of glucocorticoid-induced osteonecrosis with nano-fullerenes
    Quanjun Cui; Fiscal Year: 2013
    ..experimental approaches such as histology, real-time PCR, western blot, flow cytometry, blood biochemistry, femur histopathology and single photon emission computed tomography (SPECT) will be employed...
  15. Skeletal Phenotyping of KOMP Mice
    Dong Guk Shin; Fiscal Year: 2013
    ..At UCONN, Dr. Adams will perform a highly automated microCT of the distal femur, vertebral body and skull to identify KO lines with abnormal skeletal architecture...
    PATRICK WILLIAM MANTYH; Fiscal Year: 2012
    ..hypotheses, the fracture pain model will be generated in adult C57BL/6J male mice following closed fracture of the femur. Transgenic mice that endogenously express GFP in restricted populations of nociceptors will be used in ..
  17. Bone Turnover Effects on Bisphosphonate Concentration in the Mandible
    Kenneth M Kozloff; Fiscal Year: 2012
    ..Fluorescence per bone surface area will be assessed in the mandible, femur, and tibia, and correlated with local levels of bone turnover to determine the role of turnover in the delivery, ..
  18. Body Composition &REE Responses to Bariatric Surgeries
    Dympna Gallagher; Fiscal Year: 2013
    ..its distribution;skeletal muscle mass;mass of liver, kidneys, heart, and brain), dual energy-X-ray absorptiometry (femur BMD, total body fat, fat-free mass, and bone mineral content), and REE...
    Michael Nevitt; Fiscal Year: 2010
    ..Severe developmental abnormalities of the acetabulum and proximal femur are known to confer a high risk for developing hip OA and joint failure at a relatively young age...
  20. Genetic Regulation of Progenitor Cells in Appendicular Skeletal Development
    Yasuhiko Kawakami; Fiscal Year: 2013
    ..to limb outgrowth, resulted in the loss of proximal-anterior skeletal elements only in the hindlimb, such as the femur, tibia and anterior digits...
  21. Diagnosis of Osteochondrosis using high field MRI
    CATHY SUE CARLSON; Fiscal Year: 2013
    ..extensive areas of cartilage necrosis), in intact and disarticulated specimens of distal humerus and distal femur (most common predilection sites in both swine and humans) from young pigs;2) Develop quantitative techniques to ..
  22. Predicting Hip Fracture Using a Biomechanical Approach
    Marian T Hannan; Fiscal Year: 2013
    ..includes both estimated forces applied to the hip during a sideways fall as well as the strength of the proximal femur. The specific goal is to investigate the contribution of trochanteric soft tissue thickness t hip fracture risk, ..
  23. Keratin hydrogel matrix for tunable growth factor delivery in bone regeneration
    Justin Saul; Fiscal Year: 2013
    ..the rate of BMP-2 delivery with keratin hydrogels on bone regeneration in a critically-sized segmental rat femur defect model...
  24. PTH Effects of Craniofacial Allografts
    Edward M Schwarz; Fiscal Year: 2013
    ..Based on this, we initiated a pre-clinical study to evaluate the effects of teriparatide in our established murine femur model of massive allografting...
  25. Load-Driven Bone Lengthening
    Ping Zhang; Fiscal Year: 2010
    ..of chondrocytes in the growth plate and lengthen the proliferative and hypertrophic zones in the distal femur and the proximal tibia? (2) Is the lengthening effect dependent on ages? (3) Does injection of insulin growth ..
  26. Effect of femoroacetabular impingement (FAI) on hip motion in young adults
    CARA L LEWIS; Fiscal Year: 2013
    ..FAI is a structural abnormality of the acetabulum ("pincer" FAI) or femur ("cam" FAI) which results in impingement between the acetabulum and femur during hip flexion and internal rotation...
  27. Cannabinoid CB2 Agonists for Treatment of Breast Cancer-Induced Bone Pain
    Todd W Vanderah; Fiscal Year: 2013
    ..stably transfected with green fluorescent protein, are injected and confined to the intramedullary space of the femur of the non-immunocompromised mice...
  28. Adiposity and Bone Loss in Spinal Cord Injury
    Leslie R Morse; Fiscal Year: 2013
    ..In contrast, the metaphyses of the distal femur and proximal tibia (i.e., above and below the knee) are the most commonly fractured sites following SCI...
  29. Wearable muscle fiber excitation system for preventing blood clot
    BERTRAM NWORAH EZENWA; Fiscal Year: 2013
    ..SEMG will be acquired with BiometricsTM surface electrodes connected to the tibia and femur muscle groups and BiometricsTM portable data acquisition system before and during MFES stimuli delivery...
  30. Repair of large osteoporotic rat calvarial defects with autologous adipose stem c
    Ming Pei; Fiscal Year: 2012
    ..Four months after the operation, the BMD of the entire femur of ten rats in each group will be measured...
  31. Bone Regeneration Via Silk Biomaterials
    David L Kaplan; Fiscal Year: 2010
    ..silk matrices functionalized with growth factors and adhesion capabilities will be studied in a rat critical sized femur defect model to optimize their design...
  32. Sustained Skeletal Benefits of Adolescent Exercise
    Tamara A Scerpella; Fiscal Year: 2012
    ..Annual dual energy X-ray absorptiometry scans of the forearm, proximal femur, lumbar spine, and total body, with concurrent peripheral quantitative computed tomography scans of the forearm, ..
  33. The Interaction of Mechanical Load and Inflammation in Tendon-Bone Healing
    Scott A Rodeo; Fiscal Year: 2010
    ..We will use a rat model of ACL reconstruction in which a tendon graft is transplanted into bone tunnels in the femur and tibia...
  34. Effectiveness of DiscontinuinG bisphosphonatEs Study (EDGE)
    Kenneth G Saag; Fiscal Year: 2013
    ..concerns have emerged about longer-term use of these agents, particularly osteonecrosis of the jaw and atypical femur fractures...
    Michael Nevitt; Fiscal Year: 1992
    ..65 and over who already have X rays of the hip, hand, and spine, bone mass measurements of the radius, os calcis, femur, and lumbar spine, and measurements of many risk factors and outcomes relevant to OA...
  36. Tensor Scale-based Methods for Assessment of Trabecular Bone Quality
    PUNAM KUMAR SAHA; Fiscal Year: 2012
    ..Most osteoporotic fractures occur at sites rich in TB (vertebrae, radius, proximal femur)...
  37. Pathogenesis of Atypical Femur Fractures on Long Term Bisphosphonate Therapy
    D Sudhaker Rao; Fiscal Year: 2013
    ..Degree of bone mineralization and bone nano-mechanical properties will also be assessed on these biopsies. ..
  38. Preoperative Planning of Femoroplasty
    Mehran Armand; Fiscal Year: 2013
    ..It is suggested that augmentation of the femur is an effective countermeasure to reduce the risk of fracture in highly osteoporotic hips...
  39. Microengineered Osteoinductive and Vasculogenic Scaffold
    Esmaiel Jabbari; Fiscal Year: 2013
    ..In Aim 3, the patterned cell-laden 3D constructs will be evaluated in vivo in rat segmental femur defect for the extent of bone formation and healing...
  40. Activators of the Pyrophosphatase Activity of Alkaline Phosphatase
    Jose Luis Millan; Fiscal Year: 2007
    ..Furthermore, [unreadable]CT analysis of femur, vertebrae and calvaria revealed higher BMD in cancellous bone of ApoE-Tnap+ and ApoE-Tnap+/+ mice compared to WT ..
  41. In Vivo Assessment of Trabecular Microstructure at the Proximal Femur
    Roland Krug; Fiscal Year: 2012
    ..In particular, osteoporotic fractures of the proximal femur are the most common and often result in high rates of morbidity and mortality...
  42. Development of a biodegradable load-bearing DBM carrier
    TIEN MIN CHU; Fiscal Year: 2006
    ..3. Load-bearing carrier combined with DBM improves final mechanical properties of the rat femur after segmental defect regeneration. Forty-five Long-Evans rats will be used to test the hypotheses...
  43. Actuated Low-Force Biopsy Tool for Versatile Bone Lesion Access with Less Trauma
    MAUREEN L MULVIHILL; Fiscal Year: 2013
    ..2. Design Validation through Cadaver Testing - Evaluate rib and femur sampling. 3...
    David Perrin; Fiscal Year: 2002
    ..at incremental forces from 0-190 Newtons to determine joint displacement (forward translation of the tibia on the femur) relative to applied force...
  45. Revitalizing Allografts for Craniofacial Reconstruction
    Edward Schwarz; Fiscal Year: 2007
    ..Although large structural allografts are commonly used for long bone replacement (tibia, femur, humerus), they remain necrotic, and thus are not usable for craniofacial reconstruction...
  46. Growth of Trabecular Bone Damage Due to Off-axis Loads
    Glen Niebur; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Fractures of the proximal femur and distal radius, both regions where trabecular bone has a major load bearing function, are common...
  47. Injectable weight-bearing bone grafts for healing of tibial plateau fractures
    Joseph C Wenke; Fiscal Year: 2013
    ..to those of trabecular bone and exceeding those of CPCs, and also undergo balanced remodeling in rabbit distal femur defects, thereby suggesting that bone-like mechanical properties are preserved during the healing process...
  48. Engineered Multi-Functional Nanofibrous Meniscus Implants
    John Esterhai; Fiscal Year: 2009
    ..In this proposal, we focus on the knee meniscus, a tissue critical for proper load transfer between the femur and the tibia, and for which current repair strategies do not restore the function...
  49. Medial Collapse Movement Impairments associated with Patellofemoral Pain
    GRETCHEN SALSICH; Fiscal Year: 2009
    ..Medial collapse has been described as a combination of excessive adduction and medial rotation of the femur, increased knee valgus, and increased lateral tibial rotation...
  50. ActiveImplant Prosthesis for Lower Limb Amputees
    JOHN FAGO; Fiscal Year: 2007
    ..Current surgical techniques for amputation of the distal femur above the knee do not provide an optimum solution for interfacing with a prosthetic socket for weight bearing and ..
    John Aloia; Fiscal Year: 2002
    ..It is true that black women have a higher bone density, protective anatomic geometry of the femur, and a larger muscle mass compared to white women...
    Wilson Hayes; Fiscal Year: 1992
    ..would be applied to the following objectives: 1) Human femurs with simulated metastatic defects in the proximal femur would be tested to failure in torsion...
  53. Durable Muscle-Prosthetic Bond for Artificial Tendons
    Natalia Juncosa Melvin; Fiscal Year: 2009
    ..This succeeded in four pilot animals - (servohydraulic testing to over 1000 N with femur fracturing without pullout)...
    Armen Sarvazyan; Fiscal Year: 2000
    ..one- or two-way measurements will be applied to cites with thin (distal ulna, tibia) or thick (humerus, proximal femur) soft tissues layers, correspondingly...
    Sharmila Majumdar; Fiscal Year: 1999
    ..in cubic specimen of human trabecular bone from the lumbar spine, distal radius, calcaneus and proximal femur and relate the fractal characteristics of the radiographs measured in three orthogonal projections to (a) the ..
  56. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..and optimize an organ culture model using continuous infusion of PS or PE particles into an explanted mouse femur containing a hollow titanium rod connected to an infusion pump and tubing over a 4-week period. Specific aim #3...
    Wilson Hayes; Fiscal Year: 2000
    ..Aim 2 will develop methods for predicting failure of the proximal femur using finite element models...
    Jorge Galante; Fiscal Year: 2000
    ..DESCRIPTION (Adapted from the Applicant's Abstract): This proposal is concerned with adaptive bone remodeling of the femur following cementless and cemented total hip arthroplasty...
    Coralease Ruff; Fiscal Year: 1992
    ..Using these techniques, bone mineral content of the distal and midshaft femur, lumbar vertebrae, and mandible-maxillae, and cortical geometry of the midshaft femur will be determined 12 months ..
    Hiroki Yokota; Fiscal Year: 2005
    ..loading model- knee joint loading - to stimulate bone formation and to strengthen mechanical properties of femur and a femoral neck...
  61. Structural MRI of trabecular bone for therapy response monitoring
    Felix Wehrli; Fiscal Year: 2009
    ..Prevailing among these are the vertebrae, wrist and proximal femur. Hip fractures are the most debilitating among osteoporotic fractures in terms of morbidity and mortality...
    Eugenie Kleinerman; Fiscal Year: 2001
    ..are at high-risk for relapse are those with metastic disease at diagnosis, with a primary tumor of the humerus, femur or trunk, or with localized but bulky (>8cm) disease at the time of diagnosis...
  63. Vertebral Fracture: Trabecular Bone Structure Assessment
    Sharmila Majumdar; Fiscal Year: 2006
    ..to accurately quantify the 3-D architecture of the trabecular bone network in the radius, calcaneus and proximal femur, and perform a rigorous evaluation of the impact of these data on the pathophysiological changes in skeletal bone ..
    TIMOTHY NORMAN; Fiscal Year: 2000
    ..examine bone histomorphology, microdamage and bone mineral content (BMC) of human cortical bone from the proximal femur obtained post-mortem from age groups under-represented in preliminary studies (> 50 years) and from age groups ..
  65. Treatment of Osteopenia in Children with Cerebral Palsy
    Richard Henderson; Fiscal Year: 2002
    ..At the conclusion of the 18-month study period bone density in the distal femur had increased 89% + 21% (mean + SE) compared to 9% + 6% in controls...