bone and bones

Summary

Summary: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.

Top Publications

  1. ncbi Sex steroids and the construction and conservation of the adult skeleton
    B Lawrence Riggs
    Division of Endocrinology and Metabolism, Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocr Rev 23:279-302. 2002
  2. ncbi Vitamin D deficiency
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    N Engl J Med 357:266-81. 2007
  3. ncbi Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003
  4. doi Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
    Mary L Bouxsein
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Bone Miner Res 25:1468-86. 2010
  5. pmc Regulation of bone mass by Wnt signaling
    Venkatesh Krishnan
    Musculoskeletal Research, Lilly Research Laboratories, Indianapolis, Indiana 462385, USA
    J Clin Invest 116:1202-9. 2006
  6. pmc Matrix-embedded cells control osteoclast formation
    Jinhu Xiong
    Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences UAMS, Little Rock, Arkansas, USA
    Nat Med 17:1235-41. 2011
  7. ncbi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    Y Y Kong
    Amgen Institute, Toronto, Ontario, Canada
    Nature 402:304-9. 1999
  8. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
  9. pmc The amazing osteocyte
    Lynda F Bonewald
    Department of Oral Biology, University of Missouri Kansas City, Kansas City, MO 64108 2784, USA
    J Bone Miner Res 26:229-38. 2011
  10. ncbi Essential role of beta-catenin in postnatal bone acquisition
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 280:21162-8. 2005

Research Grants

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
  3. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
  4. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
  5. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
  6. Sogol Mostoufi-Moab; Fiscal Year: 2016
  7. MERVYN N WEITZMANN; Fiscal Year: 2016
  8. James D Bryers; Fiscal Year: 2016
  9. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
  10. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010

Detail Information

Publications607 found, 100 shown here

  1. ncbi Sex steroids and the construction and conservation of the adult skeleton
    B Lawrence Riggs
    Division of Endocrinology and Metabolism, Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocr Rev 23:279-302. 2002
    ..Thus, both sex steroids are important for developing peak bone mass, but E deficiency is the major determinant of age-related bone loss in both sexes...
  2. ncbi Vitamin D deficiency
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    N Engl J Med 357:266-81. 2007
  3. ncbi Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003
    ..Niche constituent cells or signalling pathways provide pharmacological targets with therapeutic potential for stem-cell-based therapies...
  4. doi Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
    Mary L Bouxsein
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Bone Miner Res 25:1468-86. 2010
    ..Other variables also may be appropriate depending on the research question and technical quality of the scan. Standard nomenclature, outlined in this article, should be followed for reporting of results...
  5. pmc Regulation of bone mass by Wnt signaling
    Venkatesh Krishnan
    Musculoskeletal Research, Lilly Research Laboratories, Indianapolis, Indiana 462385, USA
    J Clin Invest 116:1202-9. 2006
    ..In this Review we discuss the current understanding of this pathway in terms of bone biology and assess whether targeting this pathway might yield novel therapeutics to treat typical bone disorders...
  6. pmc Matrix-embedded cells control osteoclast formation
    Jinhu Xiong
    Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences UAMS, Little Rock, Arkansas, USA
    Nat Med 17:1235-41. 2011
    ..These results suggest that the rate-limiting step of matrix resorption is controlled by cells embedded within the matrix itself...
  7. ncbi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    Y Y Kong
    Amgen Institute, Toronto, Ontario, Canada
    Nature 402:304-9. 1999
    ..These results show that both systemic and local T-cell activation can lead to OPGL production and subsequent bone loss, and they provide a novel paradigm for T cells as regulators of bone physiology...
  8. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
    ..However, new and more effective approaches are likely to emerge from a better understanding of the regulators of bone cell function...
  9. pmc The amazing osteocyte
    Lynda F Bonewald
    Department of Oral Biology, University of Missouri Kansas City, Kansas City, MO 64108 2784, USA
    J Bone Miner Res 26:229-38. 2011
    ..Therefore, healthy, viable osteocytes are necessary for proper functionality of bone and other organs...
  10. ncbi Essential role of beta-catenin in postnatal bone acquisition
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 280:21162-8. 2005
    ..These findings suggest that Wnt/beta-catenin signaling in osteoblasts coordinates postnatal bone acquisition by controlling the differentiation and activity of both osteoblasts and osteoclasts...
  11. ncbi Mechanisms of disease: is osteoporosis the obesity of bone?
    Clifford J Rosen
    The Jackson Laboratory in Bar Harbor, ME 04401, USA
    Nat Clin Pract Rheumatol 2:35-43. 2006
    ....
  12. ncbi Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
    Hiroshi Takayanagi
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    Nat Rev Immunol 7:292-304. 2007
    ....
  13. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
    ..Our findings suggest a bone-renal axis that is central to guiding proper mineral metabolism...
  14. pmc RANK is essential for osteoclast and lymph node development
    W C Dougall
    Immunex Corporation, Seattle, Washington 98101 USA
    Genes Dev 13:2412-24. 1999
    ..These experiments reveal that RANK provides critical signals necessary for lymph node organogenesis and osteoclast differentiation...
  15. ncbi Bone development
    B R Olsen
    Harvard Medical School, Department of Cell Biology, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 16:191-220. 2000
    ....
  16. ncbi Osteocyte regulation of bone mineral: a little give and take
    G J Atkins
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia
    Osteoporos Int 23:2067-79. 2012
    ..The sheer number of osteocytes in bone means that "a little give and take" in terms of regulation of bone mineral content translates into a powerful whole organism effect...
  17. ncbi Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
    Takako Koga
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 428:758-63. 2004
    ..These results reveal that RANKL and M-CSF are not sufficient to activate the signals required for osteoclastogenesis...
  18. ncbi Transforming growth factor-beta1 to the bone
    Katrien Janssens
    Department of Medical Genetics, University of Antwerp, Campus Drie Eiken, 2610 Antwerp, Belgium
    Endocr Rev 26:743-74. 2005
    ..This review provides an overall picture of the bone-specific actions of TGF-beta1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine...
  19. doi Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus
    M Saito
    Department of Orthopaedic Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Osteoporos Int 21:195-214. 2010
    ..In this review, we describe age-related changes in collagen cross-links in bone and abnormalities of cross-links in osteoporosis and diabetes that have been reported in the literature...
  20. doi Calcium metabolism in health and disease
    Munro Peacock
    Indiana University Medical School, Indianapolis, Indiana, USA
    Clin J Am Soc Nephrol 5:S23-30. 2010
    ..Further research is needed to elucidate the risks and mechanisms of soft tissue calcification with calcium supplementation in both healthy subjects and CKD-MBD patients...
  21. ncbi The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
    P Smits
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Cell 1:277-90. 2001
    ..L-Sox5 and Sox6 are thus redundant, potent enhancers of chondroblast functions, thereby essential for endochondral skeleton formation...
  22. doi Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling
    Chuwen Lin
    Bio X Center, Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    J Bone Miner Res 24:1651-61. 2009
    ..Our findings also indicated sclerostin is a promising target for preventing disuse osteoporosis...
  23. pmc Cancer to bone: a fatal attraction
    Katherine N Weilbaecher
    Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Cancer 11:411-25. 2011
    ..Basic findings of tumour-bone interactions have uncovered numerous therapeutic opportunities that focus on the bone microenvironment to prevent and treat bone metastases...
  24. pmc Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo
    Kyu Sang Joeng
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 359:222-9. 2011
    ..Thus, Lrp5 and 6 redundantly control embryonic skeletal development, likely through β-catenin signaling...
  25. doi The contribution of bone to whole-organism physiology
    Gerard Karsenty
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 481:314-20. 2012
    ....
  26. ncbi Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    S C Manolagas
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Endocr Rev 21:115-37. 2000
    ....
  27. ncbi Androgens and bone
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocr Rev 25:389-425. 2004
    ..In conclusion, androgens may protect men against osteoporosis via maintenance of cancellous bone mass and expansion of cortical bone. Such androgen action on bone is mediated by the AR and ERalpha...
  28. doi Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    Xiaodong Li
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California 91320 1799, USA
    J Bone Miner Res 24:578-88. 2009
    ....
  29. doi Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice
    Toshihiro Sugiyama
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Bone 43:238-48. 2008
    ..Together, these data suggest that in female C57BL/6 mice, under some but not all circumstances, mechanical loading exerts an osteogenic response with iPTH (1-34) in trabecular and cortical bone...
  30. ncbi Mechanical properties and the hierarchical structure of bone
    J Y Rho
    Department of Biomedical Engineering, University of Memphis, TN 38152, USA
    Med Eng Phys 20:92-102. 1998
    ....
  31. ncbi Bone and haematopoietic defects in mice lacking c-fos
    Z Q Wang
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Nature 360:741-5. 1992
    ..These data define the c-Fos protein as an essential molecule for the development of specific cellular compartments...
  32. ncbi Biomechanical consequences of scaling
    Andrew A Biewener
    Concord Field Station, Department of Organismic and Evolutionary Biology, Harvard University, Old Causeway Road, Bedford, MA 01730, USA
    J Exp Biol 208:1665-76. 2005
    ..Other 'low stress' tendons have larger safety factors, indicating that their primary design is for stiffness to reduce the amount of stretch that their muscles must overcome when contracting to control movement...
  33. ncbi Comparison and optimization of ancient DNA extraction
    Nadin Rohland
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Biotechniques 42:343-52. 2007
    ..Finally, we observed a marked difference in the performance between different types of DNA polymerases, as measured by amplification success...
  34. doi Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
    R G G Russell
    Nuffield Department of Orthopaedic Surgery, Oxford University Institute of Musculoskeletal Sciences The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK
    Osteoporos Int 19:733-59. 2008
    ..There is new knowledge about how they work. The differences that exist among individual BPs in terms of mineral binding and biochemical actions may explain differences in their clinical behavior and effectiveness...
  35. pmc Height adjustment in assessing dual energy x-ray absorptiometry measurements of bone mass and density in children
    Babette S Zemel
    The Children s Hospital of Philadelphia, 3535 Market Street, Room 1560, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 95:1265-73. 2010
    ..No consensus exists on how to adjust BMC or BMD (BMC/BMD) measurements for short or tall stature...
  36. doi The osteoblast: an insulin target cell controlling glucose homeostasis
    Thomas L Clemens
    Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Bone Miner Res 26:677-80. 2011
    ..Our findings establish that the osteoblast is an important target used by insulin to control whole-body glucose homeostasis and identify bone resorption as the mechanism regulating osteocalcin activation...
  37. pmc Lrp5 functions in bone to regulate bone mass
    Yajun Cui
    Orthopedic Research Laboratories, Department of Orthopedic Surgery, Children s Hospital, Boston, Massachusetts, USA
    Nat Med 17:684-91. 2011
    ..These data indicate that Lrp5 signaling functions locally, and they suggest that increasing LRP5 signaling in mature bone cells may be a strategy for treating human disorders associated with low bone mass, such as osteoporosis...
  38. pmc Growth hormone, insulin-like growth factors, and the skeleton
    Andrea Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    Endocr Rev 29:535-59. 2008
    ..GH and IGF-I secretion are decreased in aging individuals, and abnormalities in the GH/IGF-I axis play a role in the pathogenesis of the osteoporosis of anorexia nervosa and after glucocorticoid exposure...
  39. ncbi A basal dromaeosaurid and size evolution preceding avian flight
    Alan H Turner
    Division of Paleontology, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024 5192, USA
    Science 317:1378-81. 2007
    ..Thus, change in theropod body size leading to flight's origin was not unidirectional...
  40. pmc Endocrine regulation of energy metabolism by the skeleton
    Na Kyung Lee
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 130:456-69. 2007
    ..By revealing that the skeleton exerts an endocrine regulation of sugar homeostasis this study expands the biological importance of this organ and our understanding of energy metabolism...
  41. pmc TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    X Yang
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 153:35-46. 2001
    ..Without these inhibition signals, chondrocytes break quiescent state and undergo abnormal terminal differentiation, ultimately leading to osteoarthritis...
  42. ncbi American College of Sports Medicine Position Stand: physical activity and bone health
    Wendy M Kohrt
    Med Sci Sports Exerc 36:1985-96. 2004
  43. pmc Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling
    Marcus Watkins
    Department of Internal Medicine and Cell Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biol Cell 22:1240-51. 2011
    ..Thus Cx43 in osteogenic cells is a critical regulator of both arms of the bone remodeling cycle, its absence causing structural changes remindful of aged or disused bone...
  44. pmc Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone
    Yue Zhang
    Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, Penn State College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 6:e23516. 2011
    ..Our results suggest that transient inhibition of connexin 43 expression and gap junctional intercellular communication may prove a potentially powerful means of enhancing the anabolic response of bone to mechanical loading...
  45. ncbi Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues
    V Kartsogiannis
    Department of Medicine, The University of Melbourne and St Vincent s Institute of Medical Research, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Bone 25:525-34. 1999
    ..RANKL was also developmentally regulated, as evidenced by its expression in the intestine, liver, and lung at E15 and newborn mouse but not in the adult...
  46. ncbi Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    Kai Yu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Development 130:3063-74. 2003
    ..Although differentiation of the osteoblast lineage was not disturbed, the proliferation of osteoprogenitors and the anabolic function of mature osteoblasts were severely affected...
  47. ncbi Comparative metagenomics of microbial communities
    Susannah Green Tringe
    Department of Energy DOE Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
    Science 308:554-7. 2005
    ..The identification of environment-specific genes through a gene-centric comparative analysis presents new opportunities for interpreting and diagnosing environments...
  48. pmc Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    Kojiro Sato
    Department of Cell Signaling, Graduate School, and COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    J Exp Med 203:2673-82. 2006
    ..Thus, Th17 is a powerful therapeutic target for the bone destruction associated with T cell activation...
  49. ncbi Bone remodeling
    Dimitrios J Hadjidakis
    Second Department of Internal Medicine, Propaedeutic and Research Institute, Athens University, Attikon University Hospital, Rimini 1, Haidari 124 62, Greece
    Ann N Y Acad Sci 1092:385-96. 2006
    ....
  50. pmc Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, New York 14642, USA
    J Clin Invest 109:1405-15. 2002
    ..These results provide a model whereby COX-2 regulates the induction of cbfa1 and osterix to mediate normal skeletal repair...
  51. ncbi TSH is a negative regulator of skeletal remodeling
    Etsuko Abe
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 115:151-62. 2003
    ..These studies define a role for TSH as a single molecular switch in the independent control of both bone formation and resorption...
  52. pmc Microarchitectural deterioration of cortical and trabecular bone: differing effects of denosumab and alendronate
    Ego Seeman
    Austin Health, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 25:1886-94. 2010
    ..001). Adverse events did not differ by group. These data suggest that structural decay owing to bone remodeling and progression of bone fragility may be prevented more effectively with denosumab...
  53. pmc Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover
    John Street
    Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland
    Proc Natl Acad Sci U S A 99:9656-61. 2002
    ....
  54. pmc DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells
    Mitsuru Yagi
    Department of Cell Differentiation, The Sakaguchi Laboratory, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Exp Med 202:345-51. 2005
    ..We have thus identified an essential regulator of osteoclast and macrophage cell fusion, DC-STAMP, and an essential role of osteoclast multinucleation in bone homeostasis...
  55. ncbi Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
    Benedetto Sacchetti
    Deparment of Experimental Medicine, La Sapienza University, 00161 Rome, Italy
    Cell 131:324-36. 2007
    ..Our data reveal the functional relationships between establishment of the HME in vivo, establishment of skeletal progenitors in BM sinusoids, and angiogenesis...
  56. pmc Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues
    Shuyuan Yeh
    Departments of Urology and Pathology, George H Whipple Lab for Cancer Research, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 99:13498-503. 2002
    ..The cre-lox ARKO mouse provides a much-needed in vivo animal model to study androgen functions in the selective androgen target tissues in female or male mice...
  57. pmc Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation
    Xiaolin Tu
    Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
    Dev Cell 12:113-27. 2007
    ..Together, these results reveal a Wnt-dependent osteogenic mechanism, and they provide a potential target pathway for designing therapeutics to promote bone formation...
  58. pmc Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities
    L Beck
    Departments of Pediatrics and Human Genetics, McGill University, Montreal Children s Hospital Research Institute, Montreal, PQ, Canada H3H 1P3
    Proc Natl Acad Sci U S A 95:5372-7. 1998
    ..Our findings demonstrate that Npt2 is a major regulator of Pi homeostasis and necessary for normal skeletal development...
  59. ncbi Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
    T Xu
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 20:78-82. 1998
    ..These mice may serve as an animal model to study the role of ECM proteins in osteoporosis...
  60. ncbi A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    Jean Jacques Body
    Department of Medicine, Institut Jules Bordet, Brussels, Belgium
    Clin Cancer Res 12:1221-8. 2006
    ..Denosumab (AMG 162), a fully human monoclonal antibody to RANKL, was developed to treat patients with skeletal diseases...
  61. ncbi Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
    Chen Zhao
    Department of Microbiology and Immunology, School of Medicine, Keio University, Shinjuku ku, Tokyo, 160 8582, Japan
    Cell Metab 4:111-21. 2006
    ..These data demonstrate that ephrin-Eph bidirectional signaling links two major molecular mechanisms for cell differentiation--one in osteoclasts and the other in osteoblasts--thereby maintaining bone homeostasis...
  62. pmc Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration
    Celine Colnot
    Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco General Hospital, San Francisco, California 94110, USA
    J Bone Miner Res 24:274-82. 2009
    ....
  63. pmc Osteoinduction, osteoconduction and osseointegration
    T Albrektsson
    Department of Biomaterials Handicap Research, Gothenburg, Sweden
    Eur Spine J 10:S96-101. 2001
    ..Osseointegration is possible in other parts of the body, but its importance for the anchorage of major arthroplasties is under debate. Ingrowth of bone in a porous-coated prosthesis may or may not represent osseointegration...
  64. ncbi Identification of the haematopoietic stem cell niche and control of the niche size
    Jiwang Zhang
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nature 425:836-41. 2003
    ..We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size...
  65. ncbi Selective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis
    Zhou Sheng Xiao
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 279:20307-13. 2004
    ..Runx2-I is sufficient for early osteoblastogenesis and intramembranous bone formation, whereas Runx2-II is necessary for complete osteoblastic maturation and endochondral bone formation...
  66. pmc Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
    Masataka Asagiri
    Department of Cell Signaling, Tokyo Medical and Dental University, Japan
    J Exp Med 202:1261-9. 2005
    ..Thus, this study establishes that NFATc1 represents a potential therapeutic target for bone disease and reveals a mechanism that underlies the essential role of NFATc1 in bone homeostasis...
  67. doi Osteocyte morphology in fibula and calvaria --- is there a role for mechanosensing?
    Aviral Vatsa
    Department of Oral Cell Biology, ACTA Universiteit van Amsterdam and Vrije Universiteit, Research Institute MOVE, Amsterdam, The Netherlands
    Bone 43:452-8. 2008
    ....
  68. pmc Circulating skeletal stem cells
    S A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA
    J Cell Biol 153:1133-40. 2001
    ..This is the first definitive proof of the existence of circulating skeletal stem cells in mammals...
  69. ncbi Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins
    Larry W Fisher
    Matrix Biochemistry Unit, Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, HHS, Bethesda, Maryland 20892 4320, USA
    Connect Tissue Res 44:33-40. 2003
    ..Two possible mechanisms for inhibiting the lytic pathway of alternate complement are presented...
  70. ncbi A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 132:1069-83. 2005
    ..By contrast, subfunction partitioning between zebrafish co-orthologs of tetrapod genes, such as sox9a and sox9b, can relax pleiotropy and reveal both early and late developmental gene functions...
  71. ncbi MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    Michael A Arnold
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 12:377-89. 2007
    ..These findings reveal unexpected commonalities in the mechanisms governing muscle, cardiovascular, and bone development with respect to their regulation by MEF2 and class II HDACs...
  72. pmc The parathyroid is a target organ for FGF23 in rats
    Iddo Z Ben-Dov
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Invest 117:4003-8. 2007
    ..These data indicate that FGF23 acts directly on the parathyroid through the MAPK pathway to decrease serum PTH. This bone-parathyroid endocrine axis adds a new dimension to the understanding of mineral homeostasis...
  73. pmc Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
    Carolina A Yoshida
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Genes Dev 18:952-63. 2004
    ..These findings demonstrate that Runx2 and Runx3 are essential for chondrocyte maturation and that Runx2 regulates limb growth by organizing chondrocyte maturation and proliferation through the induction of Ihh expression...
  74. ncbi Osteogenesis imperfecta
    Frank Rauch
    Genetics Unit, Shriners Hospital for Children and McGill University, 1529 Cedar Avenue, Montreal, Quebec, Canada H3G 1A6
    Lancet 363:1377-85. 2004
    ..Although this treatment does not constitute a cure, it is an adjunct to physiotherapy, rehabilitation, and orthopaedic care. Gene-based therapy presently remains in the early stages of preclinical research...
  75. ncbi 45S5 Bioglass-derived glass-ceramic scaffolds for bone tissue engineering
    Qizhi Z Chen
    Department of Materials and Centre for Tissue Engineering and Regenerative Medicine, Imperial College London, Prince Consort Road, London SW7 2BP, UK
    Biomaterials 27:2414-25. 2006
    ....
  76. ncbi BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
    Kunikazu Tsuji
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Nat Genet 38:1424-9. 2006
    ..Collectively, our results identify BMP2 as an endogenous mediator necessary for fracture repair...
  77. ncbi Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering
    Huanan Wang
    Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610064, PR China
    Biomaterials 28:3338-48. 2007
    ..All these results indicate that the scaffolds fulfill the basic requirements of bone tissue engineering scaffold, and have the potential to be applied in orthopedic, reconstructive and maxillofacial surgery...
  78. doi Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis
    Ichiro Takada
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Nat Rev Rheumatol 5:442-7. 2009
    ..This article summarizes Wnt and PPARgamma signaling in MSCs and the crosstalk between these pathways, and speculates on future clinical application of this knowledge as the basis of novel approaches for regeneration therapy...
  79. pmc Role of NF-κB in the skeleton
    Deborah Veis Novack
    Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Cell Res 21:169-82. 2011
    ..In this review, we will describe the roles of various NF-κB proteins in basal bone homeostasis and disease states, and explore how NF-κB inhibition might be utilized therapeutically...
  80. doi In vivo effects of modification of hydroxyapatite/collagen composites with and without chondroitin sulphate on bone remodeling in the sheep tibia
    Wolfgang Schneiders
    Department of Trauma and Reconstructive Surgery, University Hospital Carl Gustav Carus, Dresden, Germany
    J Orthop Res 27:15-21. 2009
    ..The number of osteopontin-positive osteoblasts and the direct bone contact were significantly higher around HA/Col/CS implants. We conclude that addition of CS enhances bone remodeling and new bone formation around HA/Col composites...
  81. doi The design and use of animal models for translational research in bone tissue engineering and regenerative medicine
    George F Muschler
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Tissue Eng Part B Rev 16:123-45. 2010
    ..The ongoing need for both continued innovation and refinement in animal model systems, and the need and value of more effective standardization are reinforced...
  82. pmc Biology of the sauropod dinosaurs: the evolution of gigantism
    P Martin Sander
    Steinmann Institute, University of Bonn, Germany
    Biol Rev Camb Philos Soc 86:117-55. 2011
    ..Mammals are limited by their extensive mastication and their vivipary, while ornithsichian dinosaurs were only limited by their extensive mastication, having greater average body sizes than mammals...
  83. ncbi A two-color acid-free cartilage and bone stain for zebrafish larvae
    M B Walker
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Biotech Histochem 82:23-8. 2007
    ..We have developed an acid-free method to stain cartilage and bone simultaneously in zebrafish larvae. This method has the additional advantage that PCR genotyping of stained specimens is possible...
  84. ncbi Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance
    L Knott
    Collagen Research Group, Division of Molecular and Cellular Biology, University of Bristol, Langford, UK
    Bone 22:181-7. 1998
    ..This review also demonstrates the potential for further study into this area to provide more subtle information into the mechanisms and etiology of disease and aging of mineralizing tissues...
  85. ncbi Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis
    Roberto E Guzman
    Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Toxicol Pathol 31:619-24. 2003
    ..This model offers a rapid and minimally invasive method to reproduce OA-like lesions in a rodent species...
  86. ncbi The P2X7 nucleotide receptor mediates skeletal mechanotransduction
    Jiliang Li
    Department of Anatomy and Cell Biology and Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:42952-9. 2005
    ..We conclude that ATP signaling through P2X7R is necessary for mechanically induced release of prostaglandins by bone cells and subsequent osteogenesis...
  87. doi Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL
    Paul J Kostenuik
    Metabolic Disorders Research, Amgen, Thousand Oaks, California 91320, USA
    J Bone Miner Res 24:182-95. 2009
    ..These huRANKL mice have potential utility for characterizing the activity of denosumab in a variety of murine bone disease models...
  88. pmc The immune system and bone
    Roberto Pacifici
    Department of Medicine, Emory University, Atlanta, GA, USA
    Arch Biochem Biophys 503:41-53. 2010
    ....
  89. ncbi Age of attainment of peak bone mass is site specific in Swedish men--The GOOD study
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Gothenburg University, Gothenburg, Sweden
    J Bone Miner Res 20:1223-7. 2005
    ..Results from this study suggest that PBM has been attained in the spine and femoral neck, but not in the radius or tibia, in 18- to 20-year-old men, in which an endosteal contraction and increase in cortical volumetric BMD is observed...
  90. ncbi Developmental plasticity in the life history of a prosauropod dinosaur
    P Martin Sander
    Institut für Paläontologie, Universitat Bonn, Nussallee 8, D 53115 Bonn, Germany
    Science 310:1800-2. 2005
    ..Individual life histories of P. engelhardti were influenced by environmental factors, as in modern ectothermic reptiles, but not in mammals, birds, or other dinosaurs...
  91. doi Estrogens maintain bone mass by regulating expression of genes controlling function and life span in mature osteoclasts
    Yuuki Imai
    Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
    Ann N Y Acad Sci 1173:E31-9. 2009
    ..In conclusion, in osteoclasts, estrogens function to inhibit bone resorption activity and vitality rather than differentiation...
  92. ncbi Bone tissue engineering: state of the art and future trends
    Antonio J Salgado
    3B s Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Macromol Biosci 4:743-65. 2004
    ..Scaffolds processed by using a methodology based on extrusion with blowing agents...
  93. pmc Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin
    Priscilla P Cherian
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Mol Biol Cell 16:3100-6. 2005
    ....
  94. pmc Osteoimmunology: interactions of the bone and immune system
    Joseph Lorenzo
    Department of Medicine, The University of Connecticut Health Center, N4054, MC5456, 263 Farmington Avenue, Farmington, Connecticut 06030 5456, USA
    Endocr Rev 29:403-40. 2008
    ..It is hoped that an appreciation of the interactions of these two organ systems will lead to better therapeutics for diseases that affect either or both...
  95. doi Electrospun materials as potential platforms for bone tissue engineering
    Jun Hyeog Jang
    Department of Biochemistry, Inha University College of Medicine, South Korea
    Adv Drug Deliv Rev 61:1065-83. 2009
    ..With the improvement in knowledge and techniques of bone-targeted nanofibrous matrices, bone tissue engineering is expected to be realized in the near future...
  96. doi Evidence for osteocyte regulation of bone homeostasis through RANKL expression
    Tomoki Nakashima
    Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
    Nat Med 17:1231-4. 2011
    ..Furthermore, the severe osteopetrotic phenotype that we observe in mice lacking RANKL specifically in osteocytes indicates that osteocytes are the major source of RANKL in bone remodeling in vivo...
  97. ncbi Bone cell proliferation on carbon nanotubes
    Laura P Zanello
    Department of Biochemistry, University of California, Riverside, 92521, USA
    Nano Lett 6:562-7. 2006
    ..There was a dramatic change in cell morphology in osteoblasts cultured on MWNTs, which correlated with changes in plasma membrane functions...
  98. ncbi Developmental morphology of the axial skeleton of the zebrafish, Danio rerio (Ostariophysi: Cyprinidae)
    Nathan C Bird
    Department of Biology, University of South Dakota, Vermillion, South Dakota 57069, USA
    Dev Dyn 228:337-57. 2003
    ..Because homology forms the basis for all evolutionary comparisons, these data are critical for integration in evo-devo studies...
  99. ncbi Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1
    A Yamaguchi
    Department of Oral Pathology, Nagasaki University School of Dentistry, Sakamoto, Japan
    Endocr Rev 21:393-411. 2000
    ..Thus, the intimate interaction between local factors such as BMPs and hedgehogs and the transcription factor, Cbfa1, is important to osteoblast differentiation and bone formation...
  100. ncbi Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus
    T Ikeda
    Department of Pathology and Immunology, Aging and Developmental Science, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Endocrinology 142:1419-26. 2001
    ..The presence of multiple RANKL-RANK pathways suggests a more complicated RANKL-RANK system for osteoclastogenesis or T cell differentiation than previously thought...
  101. ncbi Regulatory mechanisms in the pathways of cartilage and bone formation
    B de Crombrugghe
    The University of Texas M D Anderson Cancer Center, Department of Molecular Genetics, 1515 Holcombe Boulevard, Box 11, Houston, Texas 77030, USA
    Curr Opin Cell Biol 13:721-7. 2001
    ....

Research Grants133 found, 100 shown here

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  3. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Ourmissionalsoincludesmonitorinbgloodsafety amongtransfusion-dependtehnatlassemipaatientsa,ndprovidingoutreachand educationservicestoallat-riskpopulationtshroughoutht estate. ..
  4. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..We propose to develop anionic, partially lipophilic hyaluronic acid derivatives as a simple mechanistically-based treatment for this chronic extraordinarily common dental disorder. ..
  5. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..The overall objective is to understand the effects of obesity, physical activity and allergic sensitization in relation to symptoms of breathlessness and airway obstruction. ..
  6. Sogol Mostoufi-Moab; Fiscal Year: 2016
    ....
  7. MERVYN N WEITZMANN; Fiscal Year: 2016
    ....
  8. James D Bryers; Fiscal Year: 2016
    ..Our goal is to develop tissue regenerative biomaterials that will also provide a short-term defense and life long immune response to specific bacterial infections ..
  9. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..abstract_text> ..
  10. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..abstract_text> ..
  11. VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2014
    ....
  12. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..Using this approach, we predict that we will be able to correlate SIV specific mucosal immune responses with reduction of viremia and protection from disease progression in macaques infected with pathogenic viruses. ..
  13. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..The existing resources for this secondary data analysis provide an unprecedented cost- efficient opportunity to build on established work and expand knowledge in this important area of public health. ..
  14. Norma S Kenyon; Fiscal Year: 2015
    ..Furthermore, MSC administration may constitute a safe and effective way to reverse rejection episodes. ..
  15. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..Cancro and Akintoe (my collaborators), and the numerous faculty members that I will interact with at the many journal club, seminar, and symposiums offered at Penn and the surrounding schools. ..
  16. Robert T Means; Fiscal Year: 2014
    ..The proposed studies can potentially lead to an enhanced understanding of the mechanisms of ACD, and therefore to more effective therapy. ..
  17. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..We are aiming at developing a PCR approach to differentiate between the forms of PDCD2 found in normal bone marrow and blood, and the PDCD2 forms associated with leukemic cells. ..
  18. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
    ....
  19. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..The overall goal of this project is use these newly identified gene products as novel therapeutic targets for detection and treatment of NSCLC. ..
  20. Paul J Shami; Fiscal Year: 2014
    ..This new drug then goes one step further: it will improve the quality of life for cancer patients, their caregivers and families by providing a significantly more effective and less painful therapy than is currently available. ..
  21. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..The proposed experiments will provide essential mechanistic insight into the previously observed radio-protective and -mitigative effects of CBLB502. ..
  22. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..Experiments are proposed in animal models to test the activity of the compound and if successful the long-term goal of this work is to take this compound in human clinical trials for the treatment of GVHD. ..
  23. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    ....
  24. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..If successful, this grant could help explain the causes of iron deficiency anemia and could help in designing better drugs to combat iron deficiency anemia. ..
  25. Jianming Qiu; Fiscal Year: 2016
    ..e., EPCs ex vivo-expanded under hypoxic conditions for B19V in this application. ..
  26. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..This proposal aims to investigate new genes that regulate the formation and activity of osteoclasts to better understand bone biology in general, and potentially to find new ways to treat these widespread bone disorders. ..
  27. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..Functional characterization of such a pathway has implications for identifying early markers of disease progression in human myeloid malignancy and rational targets for molecular therapeutic approaches to diseases such as CML and MDS. ..
  28. Sharon M Moe; Fiscal Year: 2014
    ..Both of these problems may be linked. The purpose of this study is to determine if a commonly used group of drugs, bisphosphonates, may help both bone and heart/blood vessel disease and determine the mechanism the drugs work. ..
  29. Junichi Sadoshima; Fiscal Year: 2016
    ..The knowledge obtained from this investigation should be useful for the development of better treatment for heart failure, ischemic injury and stem cell therapy. ..
  30. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ....
  31. Thomas L Clemens; Fiscal Year: 2016
    ..An understanding of this pathway should ultimately enable better management of diabetic veterans and conceivably lead to the design a single therapy, which can simultaneously target both osteoporosis and type 2 diabetes. ..
  32. ANDREW GREGORY SIKORA; Fiscal Year: 2015
    ..abstract_text> ..
  33. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The Project of bi-functional pan-IgE therapeutics may yield a commercializable product for treating IgE-mediated allergic diseases of different indications. ..
  34. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010
    ..If this project is successful, it will prevent much human suffering, enable people to return to work more quickly, and save money. ..
  35. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..Its relatively small scale and concentrated focus promotes interaction and collaboration between participants across the globe. The meeting provides an excellent training environment for junior investigators and trainees. ..
  36. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    ..An interaction between this pathway and 2-catenin may enhance FOXO1-mediated transcription and regulate the anti-osteoclastogenic properties of 2-catenin. ..
  37. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..Acquired abnormalities of FA genes and FA gene expression have been reported in patients with sporadic malignancies of plasma cells, leukemia, head and neck cancer, lung cancer, and ovarian cancer. ..
  38. DANIEL J CARR; Fiscal Year: 2015
    ..Alternatively, mediators of neuropathogenesis can be targeted to alleviate collateral damage and thus, preservation of neurons in patients that suffer from acute or recurrent HSV-1 CNS or peripheral nerve infection. ..
  39. Yaya Wang; Fiscal Year: 2014
    ..In this grant I wil study the function of a genetic variant associated with multiple autoimmune diseases, the PTPN22 1858T variant, to examine its role in immune responses and disease pathogenesis. ..
  40. JAMES M COGHILL; Fiscal Year: 2015
    ..Through these experiences, Dr. Coghill will obtain the skills necessary to transition to an independent, NIH funded laboratory investigator. ..
  41. Brian F Volkman; Fiscal Year: 2016
    ..New inhibitors and variants of SDF developed in this project will likely find application as diagnostic and therapeutic agents in a wide range of human diseases, including cardiovascular disease, cancer and multiple sclerosis. ..
  42. SAMUEL SCOTT MURRAY; Fiscal Year: 2014
    ..We will also determine how the native bone protein spp24 (secreted phosphoprotein-24 kDa) inhibits BMP/TGF-b-dependent tumor cell growth. ..
  43. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ....
  44. Cell signaling as a leukemia biomarker
    JAMES WILLIAM JACOBBERGER; Fiscal Year: 2013
    ....
  45. CHARLES RICHARD STEELE; Fiscal Year: 2016
    ....
  46. Md Mizanur Rahman; Fiscal Year: 2014
    ..abstract_text> ..
  47. Identification of Proteins Important for Male Osteoporosis
    Hong Wen Deng; Fiscal Year: 2013
    ..This project aims to identify proteins that are important to male osteoporosis. The findings will provide essential scientific basis for effective prevention, diagnosis and treatment of the disease. ..
  48. ELIZABETH ANN EKLUND; Fiscal Year: 2016
    ..Targeting these mechanisms may lead to cure in CML by abolishing the CSC/LSC, and suggest therapeutic approaches to other forms of cancer with dysregulation of Fas and bcatenin. ..
  49. JUSTIN RODNEY SAVAGE; Fiscal Year: 2015
    ....
  50. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..abstract_text> ..
  51. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ....
  52. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..These results are expected to reveal deeper insight into interactive roles of inflammatory mediators in marrow regeneration and have relevance for combinatorial targeting to direct clinical outcome in transfusion biology. ..
  53. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2012
    ..Better understanding of the protecting cellular mechanisms that are in effect during septic conditions could lead to advanced protocols in treating the critically ill. ..
  54. Keith T Wilson; Fiscal Year: 2016
    ..These studies will have a major impact on our understanding of H. pylori immunopathogenesis and gastric carcinogenesis, and will lead to new approaches for risk assessment and treatment. ..
  55. Mark S Nanes; Fiscal Year: 2014
    ..Understanding this mechanism will allow us to find new medications that stimulate new bone formation and regeneration of tissue in veterans who suffer from arthritis, aging, and menopause associated fractures. ..
  56. Role of Glutathione S-Transferase P in Heart Failure
    Sumanth D Prabhu; Fiscal Year: 2013
    ....
  57. Anisa Shaker; Fiscal Year: 2016
    ..These studies may provide the basis for novel therapeutic approaches to inflammatory bowel disease and CAC. ..
  58. Runx Proteins and Sex Steroid Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2009
    ..They will decipher cryptic mechanisms of action of existing SERMs, and support the rationale development of novel ones, based on their influence on Runx proteins. ..
  59. PAUL CHRISTIAN SCHILLER; Fiscal Year: 2015
    ..Aim 3: Determine the role of progerin in the bone forming capacity of hMSCs in vivo. We expect that increased progerin expression in hMSCs will decrease their bone forming capacity in vivo. ..
  60. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..In addition, in vivo studies will be conducted to examine the ability of antioxidants to block EtOH-induced bone resorption. ..
  61. PEARLIE K BURNETTE; Fiscal Year: 2016
    ..Additionally, the efficacy of pharmacological inhibitors to block homing to the bone marrow will be tested to provide critical pre-clinical data for application to clinical studies in patients in the future. ..
  62. Non-coding RNA engineers antibody diversity
    Uttiya Basu; Fiscal Year: 2011
    ..Antibodies are polypeptide complexes produced from B-lymphocytes that are present in the bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign antigens, such as bacteria and viruses. ..
  63. Ted A Bateman; Fiscal Year: 2015
    ....
  64. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..The goal of this project is to use chemical screening to identify novel drugs to treat one type of CMT and test them in mouse models of the disease. ..
  65. Mechanisms of Bone Loss from Administration of the Second-Generation Antipsychoti
    KATHERINE JEAN MOTYL; Fiscal Year: 2013
    ..My results will also add to the increasing evidence for a key role of the nervous system in regulating skeletal homeostasis. ..
  66. Patrick Cahan; Fiscal Year: 2016
    ..An extensive program of formal training, course-work, meetings with the advisory committee, and dedicated supervision and mentorship by Dr. Daley will ensure that these goals are achieved. ..
  67. CLIFFORD JAMES ROSEN; Fiscal Year: 2015
    ..Importantly, these studies will shed new light on the ErbB and Dock7 signaling pathways in bone and in BAT. Defining shared metabolic-skeletal networks may lead to new treatments for age-related osteoporosis. ..
  68. Henryk F Urbanski; Fiscal Year: 2014
    ..These efforts have the potential to provide a new therapeutic approach to improve immunity in the growing elderly population. ..
  69. Sienmi Du; Fiscal Year: 2014
    ....
  70. Claire Larmonier; Fiscal Year: 2014
    ..Those specific aims will help address the following hypothesis: PARP1 contributes to aggravated mucosal immune response via modulation of inflammatory signaling pathways within the cells of the innate immune system. ..
  71. Jakub Tolar; Fiscal Year: 2016
    ..If the studies outlined in this application are successful, these pre-clinical data will pave the way for approval of iPSC-based clinical trials for not only other forms of EB, but also other inherited skin disorders. ..
  72. GEORGE NORBERT COX; Fiscal Year: 2015
    ..The drug should prove useful for treating other diseases for which G-CSF is used as a therapy, such as neutropenia resulting from chemotherapy use in cancer patients. ..
  73. Ara Nazarian; Fiscal Year: 2014
    ..abstract_text> ..
  74. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..The long term goal of this project is to develop a safe, effective, and cost-efficient therapy to treat RA. ..
  75. Oliver W Press; Fiscal Year: 2014
    ..We therefore anticipate rapid translation of the optimized promising pretargeted RIT into our clinical RIT HCT program for AML and MDS. ..
  76. Joshua F Baker; Fiscal Year: 2016
    ....
  77. JONATHAN JAMES HANSEN; Fiscal Year: 2014
    ..coli GadAB in experimental IBD's, 3) increase understanding of how IBD's develop, and 4) lead to future studies of manipulating bacterial stress responses for therapeutic purposes. ..
  78. THEA NOREEN GOLDEN; Fiscal Year: 2015
    ..Identification of the mechanism may result in discovery of novel therapeutic targets. This work provides a basis for a career studying other pharmacologic manipulations and injury models. ..
  79. Suzette Laing; Fiscal Year: 2016
    ..This research proposal supports training necessary for the applicant's career goal to become a dentist-scientist studying translational research in regenerative dentistry. ..
  80. Yan Zhang; Fiscal Year: 2016
    ..UC Berkeley and UC San Francisco offer world-class research environments and support for the preparation and training of young scientists for independent research careers. ..
  81. Novel Drug VS-105 for Treatment of Osteoporosis
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..Assuming Vidasym's VS-105 has a modest 5% penetration into the osteoporosis market, the estimated annual sales will be US$0.6+ billion. ..
  82. Bethany B Moore; Fiscal Year: 2016
    ..via which periostin and TGFb regulate each other and the function of lung mesenchymal cells Aim 4) To determine whether periostin levels in plasma or bronchoalveolar lavage fluid of IPF patients correlate with disease progression ..
  83. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2013
    ..This proposal could provide new strategies to prevent or treat diabetes. ..
  84. ANDREW GEORGE MUNTEAN; Fiscal Year: 2014
    ..These studies focus on the MLL-PAFc interaction and ubiquitination of MLL which are directly relevant to MLL and HOX dependent leukemias and may prove as effective therapeutic targets. ..
  85. ERNESTO ROQUE BONGARZONE; Fiscal Year: 2016
    ....
  86. Song Yao; Fiscal Year: 2015
    ..In the Pathways Study, we now have an exceptional opportunity to address an important gap in breast cancer survivorship research, and to reduce the burden of AI-induced osteoporotic fractures in a real-world clinical setting. ..
  87. Bruce Neil Cronstein; Fiscal Year: 2014
    ..unreadable] ..
  88. RUBIE ANN RAKIAN; Fiscal Year: 2016
    ..Through these studies, I will acquire state-of-the-art knowledge and skills toward my goal to become an established dentist- scientist. ..
  89. FASEB SRC on
    Bradley K Yoder; Fiscal Year: 2013
    ..T capitalize on the diversity of attendees, we also have "Interest Group Tables" for lunch and dinner to foster interactions between established and junior investigators. ..
  90. Mitchell W Mutz; Fiscal Year: 2014
    ..fumigatus wild-type and antifungal resistant strains, potentially transforming the treatment paradigm for IA. ..
  91. Peng Huang; Fiscal Year: 2016
    ....
  92. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2013
    ..Successful completion of this study will provide a molecular basis for the development of new and more specific antiresorptive agents for treating these devastating diseases. ..
  93. Yan Chun Li; Fiscal Year: 2016
    ..These studies will greatly advance our understanding of chemopreventive mechanisms of VD against colon cancer. ..
  94. Julie Paik; Fiscal Year: 2016
    ..Paik will be able to successfully further develop and refine her research skills and work towards her goal of becoming an independent clinical investigator in the field of bone and mineral metabolism. ..