lower esophageal sphincter

Summary

Summary: The physiologic or functional barrier to GASTROESOPHAGEAL REFLUX at the esophagogastric junction. Sphincteric muscles remain tonically contracted during the resting state and form the high-pressure zone separating the lumen of the ESOPHAGUS from that of the STOMACH. (Haubrich et al, Bockus Gastroenterology, 5th ed., pp399, 415)

Top Publications

  1. ncbi Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 131:1725-33. 2006
  2. ncbi A unique longitudinal muscle contraction pattern associated with transient lower esophageal sphincter relaxation
    Arash Babaei
    Division of Gastroenterology, San Diego VA Health Care System and University of California, San Diego, California
    Gastroenterology 134:1322-31. 2008
  3. pmc Obesity and gastroesophageal reflux: quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptoms
    Shahin Ayazi
    Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St, Ste 514, Los Angeles, CA 90033, USA
    J Gastrointest Surg 13:1440-7. 2009
  4. ncbi Manometric changes of the lower esophageal sphincter after sleeve gastrectomy in obese patients
    Italo Braghetto
    Department of Surgery, Faculty of Medicine, University of Chile, Santos Dumont 999, Santiago, Chile
    Obes Surg 20:357-62. 2010
  5. ncbi The impact of continuous positive airway pressure on the lower esophageal sphincter
    Kelly L Shepherd
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    Am J Physiol Gastrointest Liver Physiol 292:G1200-5. 2007
  6. ncbi Effects of dexmedetomidine and propofol on lower esophageal sphincter and gastroesophageal pressure gradient in healthy volunteers
    Alparslan Turan
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, OH 44195, USA
    Anesthesiology 112:19-24. 2010
  7. ncbi Dysfunction of the lower esophageal sphincter and dysmotility of the tubular esophagus in morbidly obese patients
    M A Küper
    Department of General, Visceral, and Transplant Surgery, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Obes Surg 19:1143-9. 2009
  8. ncbi An endoscopically implantable device stimulates the lower esophageal sphincter on demand by remote control: a study using a canine model
    J O Clarke
    Johns Hopkins Hospital, Baltimore, Maryland, USA
    Endoscopy 39:72-6. 2007
  9. ncbi The effects of cricoid pressure, remifentanil, and propofol on esophageal motility and the lower esophageal sphincter
    Kristian Thorn
    Department of Anesthesiology and Intensive Care, Orebro University Hospital, 701 85 Orebro, Sweden
    Anesth Analg 100:1200-3. 2005
  10. ncbi Effect of lower esophageal sphincter distension and acidification on esophageal pressure and electromyographic activity: the identification of the "sphinctero-esophageal excitatory reflex"
    Ahmed Shafik
    Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
    Ann Thorac Surg 79:1126-31; discussion 1131. 2005

Detail Information

Publications224 found, 100 shown here

  1. ncbi Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 131:1725-33. 2006
    ..was to perform a detailed analysis of the mechanics leading to esophagogastric junction (EGJ) opening during transient lower esophageal sphincter relaxations (tLESRs) using high-resolution manometry coupled with simultaneous fluoroscopy.
  2. ncbi A unique longitudinal muscle contraction pattern associated with transient lower esophageal sphincter relaxation
    Arash Babaei
    Division of Gastroenterology, San Diego VA Health Care System and University of California, San Diego, California
    Gastroenterology 134:1322-31. 2008
    ..of the longitudinal muscle of the esophagus may play a role in the relaxation and opening of the lower esophageal sphincter (LES)...
  3. pmc Obesity and gastroesophageal reflux: quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptoms
    Shahin Ayazi
    Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St, Ste 514, Los Angeles, CA 90033, USA
    J Gastrointest Surg 13:1440-7. 2009
    ..The aim of this study is to quantify the relationship between body mass index (BMI) and 24-h esophageal pH measurements and the status of the lower esophageal sphincter (LES) in patients with reflux symptoms.
  4. ncbi Manometric changes of the lower esophageal sphincter after sleeve gastrectomy in obese patients
    Italo Braghetto
    Department of Surgery, Faculty of Medicine, University of Chile, Santos Dumont 999, Santiago, Chile
    Obes Surg 20:357-62. 2010
    ..Laparoscopic sleeve gastrectomy has been accepted as an option for surgical treatment of obesity. After surgery, some patients present reflux symptoms associated with endoscopic esophagitis, therefore PPI's treatment must be indicated...
  5. ncbi The impact of continuous positive airway pressure on the lower esophageal sphincter
    Kelly L Shepherd
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    Am J Physiol Gastrointest Liver Physiol 292:G1200-5. 2007
    The lower esophageal sphincter (LES) is the primary barrier to gastroesophageal reflux. Reflux is associated with periods of LES relaxation, as occurs during swallowing...
  6. ncbi Effects of dexmedetomidine and propofol on lower esophageal sphincter and gastroesophageal pressure gradient in healthy volunteers
    Alparslan Turan
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, OH 44195, USA
    Anesthesiology 112:19-24. 2010
    Many anesthetics reduce lower esophageal sphincter pressure (LESP)...
  7. ncbi Dysfunction of the lower esophageal sphincter and dysmotility of the tubular esophagus in morbidly obese patients
    M A Küper
    Department of General, Visceral, and Transplant Surgery, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Obes Surg 19:1143-9. 2009
    ..Morbid obesity is associated with gastroesophageal reflux (GERD). The aim of this prospective study was to determine esophageal motility in asymptomatic morbidly obese patients and compare it to non-obese individuals...
  8. ncbi An endoscopically implantable device stimulates the lower esophageal sphincter on demand by remote control: a study using a canine model
    J O Clarke
    Johns Hopkins Hospital, Baltimore, Maryland, USA
    Endoscopy 39:72-6. 2007
    ..Selective stimulation to increase lower esophageal sphincter (LES) pressure may be useful in the control of gastroesophageal reflux disease...
  9. ncbi The effects of cricoid pressure, remifentanil, and propofol on esophageal motility and the lower esophageal sphincter
    Kristian Thorn
    Department of Anesthesiology and Intensive Care, Orebro University Hospital, 701 85 Orebro, Sweden
    Anesth Analg 100:1200-3. 2005
    ..purpose of this study was to investigate the effects of cricoid pressure, remifentanil, and propofol on lower esophageal sphincter (LES) and esophageal motility...
  10. ncbi Effect of lower esophageal sphincter distension and acidification on esophageal pressure and electromyographic activity: the identification of the "sphinctero-esophageal excitatory reflex"
    Ahmed Shafik
    Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
    Ann Thorac Surg 79:1126-31; discussion 1131. 2005
    ..We investigated the hypothesis that lower esophageal sphincter (LES) dilatation rather than the refluxed acid affected reflex increase in the esophageal peristaltic ..
  11. pmc Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter
    YanFen Jiang
    Division of Gastroenterology, San Diego Veterans Affairs Healthcare System and University of California, San Diego, San Diego, California 92161, USA
    Am J Physiol Gastrointest Liver Physiol 297:G397-405. 2009
    ..found that an orally directed stretch of the esophagus activates a neurally mediated relaxation of the lower esophageal sphincter (LES)...
  12. ncbi Neurotransmission in lower esophageal sphincter of W/Wv mutant mice
    Y Zhang
    Division of Gastroenterology, Hotel Dieu Hospital, 166 Brock St, Kingston, Ontario K7L5G2, Canada
    Am J Physiol Gastrointest Liver Physiol 298:G14-24. 2010
    ..ICC) in nitrergic neurotransmission to gastrointestinal smooth muscle, circular smooth muscle from the lower esophageal sphincter (LES) of W/W(v) wild-type and mutant (ICC-deficient) mice were studied by using intracellular and ..
  13. ncbi Barrett's esophagus and medications that relax the lower esophageal sphincter
    Douglas A Corley
    Northern California Kaiser Permanente Division of Research, Oakland 94612, USA
    Am J Gastroenterol 101:937-44. 2006
    ..We evaluated patients with a high-risk condition, Barrett's esophagus, to identify risk factors that may act early in the carcinogenic process...
  14. ncbi Obesity is associated with increased transient lower esophageal sphincter relaxation
    Justin Che Yuen Wu
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Gastroenterology 132:883-9. 2007
    ..We evaluated the association between obesity and function of lower esophageal sphincter (LOS) in subjects without GERD.
  15. ncbi Transient lower esophageal sphincter relaxations in dogs are inhibited by a metabotropic glutamate receptor 5 antagonist
    Jorgen Jensen
    AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    Eur J Pharmacol 519:154-7. 2005
    Transient lower esophageal sphincter relaxation is the major mechanism for gastroesophageal reflux...
  16. ncbi Novel treatments of GERD: focus on the lower esophageal sphincter
    A Lehmann
    Bioscience, AstraZeneca R and D, Molndal, Sweden
    Eur Rev Med Pharmacol Sci 12:103-10. 2008
    ..The lower esophageal sphincter (LES) plays a crucial role in maintaining the mechanical barrier necessary for prevention of gastric ..
  17. ncbi Manometric study of lower esophageal sphincter in children with primary acid gastroesophageal reflux and acid gastroesophageal reflux secondary to food allergy
    J Semeniuk
    III Department of Pediatrics, Medical University of Bialystok, Bialystok, Poland
    Adv Med Sci 53:283-92. 2008
    The comparison of values of selected lower esophageal sphincter (LES) manometric parameters measured in children suspected of gastroesophageal reflux disease (GERD) (preliminary study) and in children with primary acid GER and acid GER ..
  18. ncbi (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action
    Anders Lehmann
    AstraZeneca R and D, Molndal, Sweden
    J Pharmacol Exp Ther 331:504-12. 2009
    ..We describe a new therapeutic approach for GERD, based on inhibition of transient lower esophageal sphincter relaxation (TLESR) with a proposed peripherally acting GABA(B) receptor agonist, (R)-(3-amino-2-..
  19. ncbi Gastroesophageal reflux disease and obesity. Pathophysiology and implications for treatment
    Fernando A M Herbella
    Department of Surgery, University of California San Francisco, CA 94143 0790, USA
    J Gastrointest Surg 11:286-90. 2007
    ..in morbidly obese (body mass index (BMI) > or =35) and nonmorbidly patients (BMI <35) with GERD: (a) lower esophageal sphincter (LES) profile; (b) esophageal body function; and (c) esophageal acid exposure...
  20. ncbi Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus tone
    Mark Niedringhaus
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
    Am J Physiol Regul Integr Comp Physiol 294:R121-31. 2008
    ..of our study were to determine the CNS site that controls the CD and whether simultaneous changes in lower esophageal sphincter (LES) pressure and CD activity occur when this site is activated...
  21. ncbi Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis
    Ling Cheng
    Division of Gastroenterology, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    Gastroenterology 129:1675-85. 2005
    We have previously used the normal lower esophageal sphincter (N-LES) of human organ donors to examine the physiologic signal transduction of lower esophageal sphincter (LES) circular muscle...
  22. ncbi Presence of GABA(B) receptors forming heterodimers with GABA(B1) and GABA(B2) subunits in human lower esophageal sphincter
    Yasuhiro Torashima
    Division of Surgery, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
    J Pharmacol Sci 111:253-9. 2009
    ..for the management of gastro-esophageal reflux disease, but whether the compound acts directly at the lower esophageal sphincter (LES) remains to be elucidated...
  23. ncbi The effects on the lower esophageal sphincter of sevoflurane induction and increased intra-abdominal pressure during laparoscopy
    K Thorn
    Department of Anesthesiology and Intensive Care, Orebro University Hospital, Orebro, Sweden
    Acta Anaesthesiol Scand 50:978-81. 2006
    ..patients was to investigate the effects of sevoflurane during inhalation induction on the lower esophageal sphincter pressure (LESP) and barrier pressure (BrP)...
  24. ncbi Transient lower esophageal sphincter relaxations do not result from passive opening of the cardia by gastric distention
    Benson T Massey
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Gastroenterology 130:89-95. 2006
    Transient lower esophageal sphincter relaxation is the main mechanism for gastroesophageal reflux...
  25. ncbi Lower esophageal sphincter pressure in patients with gastroesophageal reflux diseases and posture and time patterns
    A Meining
    Department of Medicine, Klinikum Innenstadt, University of Munich, Germany
    Dis Esophagus 17:155-8. 2004
    Gastroesophageal reflux disease is caused predominantly by lower esophageal sphincter insufficiency...
  26. ncbi Response of the lower esophageal sphincter to gastric distention by carbonated beverages
    Nahid Hamoui
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Gastrointest Surg 10:870-7. 2006
    Gastroesophageal reflux disease often occurs in patients with normal resting pressure and length of the lower esophageal sphincter. Such patients often have postprandial reflux. The mechanism of postprandial reflux remains controversial...
  27. ncbi The value of high-resolution manometry in the assessment of the resting characteristics of the lower esophageal sphincter
    Shahin Ayazi
    Division of Thoracic and Foregut Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA, USA
    J Gastrointest Surg 13:2113-20. 2009
    ..There has been less emphasis on the use of HRM to evaluate the lower esophageal sphincter (LES) resting pressure and length, both factors important in LES barrier function...
  28. ncbi Transient lower esophageal sphincter relaxation in morbid obesity
    J H Schneider
    Department of General, Visceral and Transplant Surgery, University Hospital of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Obes Surg 19:595-600. 2009
    ..Gastroesophageal reflux is caused predominantly by transient lower esophageal sphincter relaxations (TLESRs)...
  29. pmc Upper esophageal sphincter during transient lower esophageal sphincter relaxation: effects of reflux content and posture
    Arash Babaei
    University of California, San Diego, USA
    Am J Physiol Gastrointest Liver Physiol 298:G601-7. 2010
    Although some studies show that the upper esophageal sphincter (UES) contracts during transient lower esophageal sphincter relaxation (TLESR), others show that it relaxes...
  30. ncbi Apnea-associated reduction in lower esophageal sphincter tone in premature infants
    Taher I Omari
    Gastroenterology Unit, Children, Youth and Women s Health Services, North Adelaide, Australia
    J Pediatr 154:374-8. 2009
    ..To characterize esophageal motility during episodes of prolonged apnea in premature infants...
  31. ncbi Inhibition of transient lower esophageal sphincter relaxations by electrical acupoint stimulation
    Duowu Zou
    Dept of Gastroenterology, Hepatology, and General Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
    Am J Physiol Gastrointest Liver Physiol 289:G197-201. 2005
    ..Gastric distension is the major trigger for transient lower esophageal sphincter (LES) relaxations (TLESRs)...
  32. ncbi The role of transsphincteric pressure and proximal gastric volume in acid reflux before and after fundoplication
    Robert C H Scheffer
    Gastrointestinal Research Unit, Department of Gastroenterology and Department of Surgery, University Medical Center, Utrecht, The Netherlands
    Gastroenterology 129:1900-9. 2005
    ..the role of proximal gastric volume and transsphincteric pressure on acid reflux during transient lower esophageal sphincter relaxation (TLESR) in patients with gastroesophageal reflux disease (GERD) both before and after ..
  33. ncbi Lower oesophageal sphincter pressure and timed barium oesophagogram: two objective parameters in the non-invasive assessment of primary achalasia
    G Montazeri
    Gastroenterology and Hepatology, Digestive Disease Research Center, Tehran University of Medical Science, Shariati Hospital, Tehran, Iran
    Aliment Pharmacol Ther 22:261-5. 2005
    ..The non-invasive assessment of primary achalasia is not precise...
  34. ncbi The real value of lower esophageal sphincter measurement for predicting acid gastroesophageal reflux or Barrett's esophagus
    Oscar Alonso
    Department of Surgery and Abdominal Organ Transplantation, 12 de Octubre University Hospital, Madrid, Spain
    J Gastrointest Surg 9:973-9. 2005
    The study goal was to ascertain the true value of lower esophageal sphincter measurement in order to establish the risk of presenting gastroesophageal reflux or Barrett's esophagus...
  35. ncbi [Effects of two test-meals on transient lower esophageal sphincter relaxation in patients with gastroesophageal reflux disease and mechanism of gastroesophageal reflux]
    Xiao Hong Sun
    Department of Gastroenterology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26:628-33. 2004
    To investigate the effects of standard meal and fat meal distending the fundus on transient lower esophageal sphincter relaxation (TLESR) and esophageal motility and to explore the mechanism of gastroesophageal reflux (GER) in patients ..
  36. ncbi Structure and function of the esophagus of the American alligator (Alligator mississippiensis)
    T J Uriona
    Department of Biology, 257 South 1400 East, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Biol 208:3047-53. 2005
    ..We observed a large increase in pressure in the lower esophageal sphincter (LES) during ventilation that ranged from 200% to 3000% of the pressures measured during apnea...
  37. ncbi Transient lower esophageal sphincter relaxations (TLESRs) are the major mechanism of gastroesophageal reflux but are not the cause of reflux disease
    Katsuhiko Iwakiri
    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Dig Dis Sci 50:1072-7. 2005
    In healthy subjects, the rate of acid reflux during transient lower esophageal sphincter relaxations (TLESRs) is more frequent at the proximal margin of the LES...
  38. ncbi Surgical treatment of achalasia: current status and controversies
    Farshad Abir
    Department of Surgery, Yale University School of Medicine, New Haven, Conn 06520 8062, USA
    Dig Surg 21:165-76. 2004
    ..To review the current management of achalasia, and the controversies regarding the different treatment options...
  39. ncbi Gastric electrical stimulation (GES) with parameters for morbid obesity elevates lower esophageal sphincter (LES) pressure in conscious dogs
    J H Xing
    Veterans Research Foundation, VAMC, Oklahoma City, OK, and Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX 77555 0632, USA
    Obes Surg 15:1321-7. 2005
    ..Treatment of obese patients with the implantable gastric stimulator (IGS) was reported to improve reflux symptoms, independent of weight loss. We evaluated the effect of gastric electrical stimulation on LES pressure in conscious dogs...
  40. ncbi Esophageal manometric changes and gastroesophageal reflux symptoms after distal gastrectomy for gastric cancer
    Norihiro Haga
    Department of Surgery, Gunma Cancer Center, Ota, Japan
    Hepatogastroenterology 52:310-3. 2005
    ..However, its mechanism is not completely understood. We investigated the effects of distal gastrectomy for gastric cancer on the lower esophageal sphincter (LES) and esophageal motility.
  41. ncbi Pneumatic balloon dilatation in primary achalasia: the long-term follow-up results
    Gungor Boztas
    Department of Internal Medicine, Gastroenterology Division, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
    Hepatogastroenterology 52:475-80. 2005
    ..Pneumatic dilatation is a safe and most effective treatment for achalasia. We analyzed the long-term results of pneumatic dilatation in primary achalasia by objective and subjective findings...
  42. ncbi Postprandial water intake inhibits gastric antral motility with increase of cholecystokinin in humans
    Motoyasu Kusano
    Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Japan
    Scand J Gastroenterol 40:1176-81. 2005
    ..The effects of postprandial water intake on the gastrointestinal tract have not been systematically investigated in humans...
  43. ncbi Reproducibility of meal-induced transient lower oesophageal sphincter relaxations in patients with gastro-oesophageal reflux disease
    G E Boeckxstaens
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Neurogastroenterol Motil 17:23-8. 2005
    ....
  44. ncbi Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis
    Denesh K Chitkara
    The Motility Unit, Division of Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, Boston, MA 02111, USA
    J Pediatr Gastroenterol Nutr 40:70-5. 2005
    ..To evaluate esophageal body motor contractions occurring during esophageal reflux in pediatric patients with gastro-esophageal reflux disease (GERD)...
  45. ncbi Abnormal acid reflux in asthmatic patients in a region with low GERD prevalence
    Jen Yuan Hsu
    Division of Chest Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    J Gastroenterol 40:11-5. 2005
    ..However, only a few data from Asia are available. This study evaluated the incidence of abnormal gastroesophageal reflux (GER) in asthmatic patients in Taiwan...
  46. ncbi Pathophysiology of gastroesophageal reflux diseases in Chinese--role of transient lower esophageal sphincter relaxation and esophageal motor dysfunction
    Wai Man Wong
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Am J Gastroenterol 99:2088-93. 2004
    Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism for gastroesophageal reflux in the Western population. The major reflux mechanism in Chinese patients with GERD has not been studied before.
  47. ncbi Manometric evaluation of achalasia in the elderly
    N Hashemi
    Division of Gastroenterology and Hepatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107 5244, USA
    Aliment Pharmacol Ther 21:431-4. 2005
    ..The effect of ageing on oesophageal motility in patients with achalasia is not well described. Oesophageal contraction amplitude is decreased in otherwise healthy elderly subjects...
  48. ncbi Preoperative esophageal manometry does not predict postoperative dysphagia following anti-reflux surgery
    S J Cole
    Department of Surgery, University of Pretoria, Pretoria, South Africa
    Dis Esophagus 18:51-6. 2005
    ..In conclusion, preoperative manometry does not predict postoperative dysphagia following laparoscopic Toupet partial fundoplication...
  49. ncbi Relationships among nocturnal jaw muscle activities, decreased esophageal pH, and sleep positions
    Shouichi Miyawaki
    Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Am J Orthod Dentofacial Orthop 126:615-9. 2004
    ..These results suggest that most jaw muscle activities, ie, RMMA, single short-burst, and clenching episodes, occur in relation to gastroesophageal reflux mainly in the supine position...
  50. ncbi Gastro-oesophageal reflux disease in infants and children: new insights, developments and old chestnuts
    Taher Omari
    Centre for Pediatric and Adolescent Gastroenterology, Women s and Children s Hospital, North Adelaide, Australia
    J Pediatr Gastroenterol Nutr 41:S21-3. 2005
  51. ncbi Clinical, radiographic, and manometric evolution of esophageal involvement by Chagas' disease
    Ulysses G Meneghelli
    Departamento de Clinica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Ribeirao Preto, Brazil
    Dysphagia 20:40-5. 2005
    ..of esophageal Chagas' disease includes nonperistaltic contractions in the esophageal body, absent lower esophageal sphincter (LES) relaxation, and dilatation of the organ...
  52. ncbi Lower esophageal sphincter analysis using computerized manometry in patients with chagasic megaesophagus
    C G Andrade
    Department of Gastroenterology, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Dis Esophagus 19:31-5. 2006
    ..of computer technology into manometry laboratories, three-dimensional manometric images of the lower esophageal sphincter can be constructed based on radially oriented pressures, a method termed 'computerized axial manometry...
  53. ncbi Gastroesophageal and pharyngeal reflux detection using impedance and 24-hour pH monitoring in asymptomatic subjects: defining the normal environment
    Brant K Oelschlager
    Swallowing Center, Department of Surgery, University of Washington, Seattle, 98195, USA
    J Gastrointest Surg 10:54-62. 2006
    ..Most reflux episodes (348 of 496) reached the mid esophagus (9 cm above lower esophageal sphincter). There were 51 reflux episodes that reached the pharynx (PR)...
  54. ncbi New observations on the gastroesophageal antireflux barrier
    Larry Miller
    Department of Gastroenterology, Temple University Hospital, Gastroenterology Section, 8th Floor, Parkinson Pavilion, Philadelphia, PA 19043, USA
    Gastroenterol Clin North Am 36:601-17, ix. 2007
    ....
  55. ncbi The lower esophageal sphincter strength in patients with gastroesophageal reflux before and after laparoscopic Nissen fundoplication
    J H Schneider
    Department of Visceral Surgery and Transplantation of University of Tübingen, Tubingen, Germany
    Dis Esophagus 20:58-62. 2007
    b>Lower esophageal sphincter pressure (LESP) and sphincter strength (LESS) were measured before and after short and floppy laparoscopic Nissen fundoplication (LNF) in 38 patients with severe gastro-esophageal reflux disease (GERD)...
  56. ncbi The effect of laparoscopic partial fundoplication on dysphagia, esophageal and lower esophageal sphincter motility
    M Y A Lindeboom
    Department of Gastroenterology Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Dis Esophagus 20:63-8. 2007
    ..Symptoms, lower esophageal sphincter (LES) characteristics and esophageal body motility were evaluated prospectively in 62 patients before ..
  57. pmc High-resolution manometry and impedance-pH/manometry: valuable tools in clinical and investigational esophagology
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Gastroenterology 135:756-69. 2008
    ..Ultimately, however, both technologies will be strengthened as outcome studies evaluating their utilization become available...
  58. ncbi Esophageal motility disorders in the morbidly obese population
    J S Koppman
    The Bariatric Institute and Section of Minimally Invasive Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA
    Surg Endosc 21:761-4. 2007
    ..investigating esophageal motility among the morbidly obese have focused on the relationship between lower esophageal sphincter (LES) pressure and gastroesophageal reflux disease (GERD)...
  59. doi Heller-type cardiomyotomy using NOTES
    A Mathew
    Endoscopy 40:352. 2008
  60. ncbi Is aperistalsis with complete lower esophageal sphincter relaxation an early stage of classic achalasia?
    Jeong Hwan Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 22:536-41. 2007
    Aperistalsis with complete lower esophageal sphincter (LES) relaxation, characterized by the complete relaxation of the LES and aperistalsis of the esophageal body on manometry, has been considered by some authors to be an early ..
  61. ncbi Mechanisms of gastroesophageal reflux in children with sequelae of birth asphyxia
    Licia Pensabene
    Department of Pediatrics, University Magna Graecia of Catanzaro, Italy
    Brain Dev 30:563-71. 2008
    ..When the rate of decrease of lower esophageal sphincter (LES) pressure was >1 mmHg/s, the decrease of LES pressure was defined as LES relaxation...
  62. ncbi Evidence for the ''paradox'' association between hypertensive lower esophageal sphincter and gastroesophageal reflux disease
    G Kouklakis
    Medical School, Democritus University of Thrace Alexandroupolis, Greece
    Minerva Gastroenterol Dietol 54:97-100. 2008
    ..Manometry revealed a hypertensive lower esophageal sphincter pressure (resting pressure 35 mmHg) and pHmetry revealed a DeMeester score > 14.72 (43.27)...
  63. ncbi Endoscope-guided pneumatic dilatation of esophageal achalasia without fluoroscopy is another safe and effective treatment option: a report of Taiwan
    Seng Kee Chuah
    Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Surg Laparosc Endosc Percutan Tech 18:8-12. 2008
    ..Thirty-three patients were treated, excellent results in 27, good results in 3, and failure in 3 (1 requiring surgical treatment later). Overall, we demonstrated that the technique is effective and safe option for achalasia treatment...
  64. ncbi High-resolution manometry
    A J Bredenoord
    Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
    Dig Liver Dis 40:174-81. 2008
    ..Further studies will have to determine whether high-resolution manometry is superior to conventional manometry in the diagnostic work-up of patients with oesophageal symptoms...
  65. ncbi Laparoscopic partial posterior (Toupet) fundoplication improves esophageal bolus propagation on scintigraphy
    H Wykypiel
    Department of General and Transplant Surgery, Medical University, Anichstrasse 35, A 6020, Innsbruck, Austria
    Surg Endosc 22:1845-51. 2008
    ..The aim of this study was to investigate the effect of laparoscopic Nissen fundoplication (NF), laparoscopic partial posterior (Toupet) fundoplication (PPF) or medical therapy on esophageal clearance...
  66. ncbi Effect of laparoscopic fundoplication on hypertensive lower esophageal sphincter associated with gastroesophageal reflux
    Gabor Varga
    Department of Surgery, Medical School, University of Pecs, Pecs, Hungary
    J Gastrointest Surg 12:304-7. 2008
    For hypertensive lower esophageal sphincter with dysphagia and chest pain, a laparoscopic cardiomyotomy is recommended. Recently, the role of gastroesophageal reflux in this abnormality has been recognized...
  67. ncbi Submucosal endoscopic esophageal myotomy: a novel experimental approach for the treatment of achalasia
    P J Pasricha
    Divison of Gastroenterology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 0764, USA
    Endoscopy 39:761-4. 2007
    ..We hypothesized that we could perform a safe and robust myotomy by working in the submucosal space, accessed from the esophageal lumen...
  68. ncbi Long-term results of conventional myotomy in patients with achalasia: a prospective 20-year analysis
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, and the Department of Gastroenterology, German Diagnostic Clinic, Wiesbaden, Germany
    J Gastrointest Surg 10:1400-8. 2006
    ..4 (range, 1-10) mm to 10 (range, 5-15) mm. The resting pressure of the lower esophageal sphincter could be reduced from 28.4 (range, 9.4-56.0) mm Hg to 8.6 (range, 3.0-22.5) mm Hg...
  69. ncbi [Functional changes in the cardioesophageal region following laparoscopic fundoplication]
    M Lovecek
    I Chirurgická klinika FN Olomouc
    Rozhl Chir 87:237-41. 2008
    ..Functional changes of antireflux mechanisms after laparoscopic fundpolication...
  70. pmc Endoscopic findings around the gastroesophageal junction: an experience from a tertiary hospital in Korea
    Ji Hyun Kim
    Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea
    Korean J Intern Med 23:127-33. 2008
    ..This study examined the distribution of endoscopic findings around the GEJ and elucidated their relationship to each other and esophageal manometric features...
  71. ncbi Physiology of reflux disease: role of the lower esophageal sphincter
    P F Crookes
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Surg Endosc 20:S462-6. 2006
    The function of the lower esophageal sphincter (LES) has historically been elucidated by two major manometric methods: the one concentrating on static parameters including resting pressure, overall length, and intraabdominal length, and ..
  72. ncbi Does laparoscopic antireflux surgery prevent the occurrence of transient lower esophageal sphincter relaxation?
    F Bahmeriz
    Department of Surgery, St Joseph s Healthcare, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Surg Endosc 17:1050-4. 2003
    Transient lower esophageal sphincter relaxation (TLESR) is the most common mechanism underlying gastroesophageal reflux disease (GERD), causing 70% to 100% of the reflux episodes in normal subjects and 63% to 74% of the reflux episodes in ..
  73. ncbi Oesophagitis is common in patients with achalasia after pneumatic dilatation
    I Leeuwenburgh
    Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 23:1197-203. 2006
    ..Treatment aims at lowering of the lower oesophageal sphincter pressure, enhancing the risk of gastro-oesophageal reflux. Nevertheless, the incidence of oesophagitis after achalasia treatment is unknown...
  74. ncbi Dor fundoplication after myotomy for achalasia: useful, unnecessary, or harmful?
    Venanzio Porziella
    J Thorac Cardiovasc Surg 132:216-7; author reply 217. 2006
  75. ncbi Laparoscopic partial myectomy: an experimental reflux model
    T P Hüttl
    Department of Surgery, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Surg Endosc 20:665-72. 2006
    ..Due to the lack of an animal model of inadequate esophageal sphincter function, most experimental studies on antireflux procedures were done on normally functioning esophageal sphincters...
  76. ncbi Effect of an acute intraluminal administration of capsaicin on oesophageal motor pattern in GORD patients with ineffective oesophageal motility
    L Grossi
    Department of Medicine and Sciences of Aging, School of Gastroenterology, c o Unit of Medicine I, Ospedale Spirito Santo, G D Annunzio University of Chieti, Pescara, Italy
    Neurogastroenterol Motil 18:632-6. 2006
    ..Whether this could represent the basis for further therapeutic approaches of GORD patients needs further study...
  77. ncbi Gastro-oesophageal reflux of liquids and gas during transient lower oesophageal sphincter relaxations
    A J Bredenoord
    Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands
    Neurogastroenterol Motil 18:888-93. 2006
    ..We conclude that factors, other than TLOSR characteristics, are important of whether or not a TLOSR is reflux-related...
  78. ncbi New esophageal function testing (impedance, Bravo pH monitoring, and high-resolution manometry): clinical relevance
    Jason A Wilson
    Division of Gastroenterology and Hepatology, Medical University of South Carolina, 25 Courtenay Drive, ART 7100A, MSC 290, Charleston, SC 29425, USA
    Curr Gastroenterol Rep 10:222-30. 2008
    ..The advantages, disadvantages, and clinical importance of these new esophageal tests are discussed in this review...
  79. ncbi Intraoperative manometry of the lower esophageal sphincter pressure during laparoscopic antireflux surgery with a mechanical calibration--early results
    Z Kala
    Department of Surgery, Faculty Hospital Brno, Bohunice, Czech Republic
    Hepatogastroenterology 53:710-4. 2006
    ..An excessive increase of the intraoperative lower esophageal sphincter pressure (LESp) is supposed to be related to the persistent postoperative dysphagia and its knowledge ..
  80. pmc Signal transduction in esophageal and LES circular muscle contraction
    K M Harnett
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Yale J Biol Med 72:153-68. 1999
    ..In contrast, lower esophageal sphincter (LES) contraction induced by maximally effective doses of ACh is mediated by muscarinic M3 receptors, ..
  81. ncbi Does major depression in patients with gastroesophageal reflux disease affect the outcome of laparoscopic antireflux surgery?
    T Kamolz
    Division of Clinical Psychology, Department of General Surgery, Public Hospital of Zell am See, Paracelsusstr 8, A 5700 Zell am See, Austria
    Surg Endosc 17:55-60. 2003
    ....
  82. ncbi Ketamine and midazolam differentially inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation in rabbits: role of superoxide anion and nitric oxide synthase
    Atsushi Kohjitani
    Department of Dental Anesthesiology, Okayama University Hospital of Dentistry, Shikata cho, Japan
    Anesthesiology 98:449-58. 2003
    ..reported that ketamine and midazolam inhibited nitric oxide-mediated nonadrenergic noncholinergic (NANC) lower esophageal sphincter (LES) relaxation nitric oxide-3',5'-cyclic guanosine monophosphate pathway modulation...
  83. ncbi Esophageal motility in patients with sliding hiatal hernia with reflux esophagitis
    Ping Ye
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Chin Med J (Engl) 121:898-903. 2008
    ..The aim of the present study was to investigate the role of acid reflux and duodenal gastroesophageal reflux (DGER), esophageal manometry, and esophageal dysmotility by applying the barium meal examination...
  84. ncbi Esophageal manometric characteristics and outcomes for laparoscopic esophageal diverticulectomy, myotomy, and partial fundoplication for epiphrenic diverticula
    Lora Melman
    Section of Minimally Invasive Surgery, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA
    Surg Endosc 23:1337-41. 2009
    The purpose of this study is to characterize the esophageal motor and lower esophageal sphincter (LES) abnormalities associated with epiphrenic esophageal diverticula and analyze outcomes for laparoscopic esophageal diverticulectomy, ..
  85. ncbi An analysis of distal esophageal impedance in individuals with and without esophageal motility abnormalities
    Wojciech Blonski
    Division of Gastroenterology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Gastroenterol 42:776-81. 2008
    ..The aim of this study was to analyze and to compare distal esophageal impedance values between healthy volunteers and patients with normal and abnormal esophageal manometry...
  86. ncbi Effects of repeated administration of baclofen on transient lower esophageal sphincter relaxation in the dog
    A Lehmann
    Gastrointestinal Pharmacology, AstraZeneca R and D Molndal, S 431 83, Molndal, Sweden
    Eur J Pharmacol 403:163-7. 2000
    ..gamma-aminobutyric acid (GABA) receptor (GABA(B) receptor) agonist baclofen inhibits transient lower esophageal sphincter relaxation in dogs, ferrets, and humans...
  87. ncbi Endoscopic injection of skeletal muscle-derived cells augments gut smooth muscle sphincter function: implications for a novel therapeutic approach
    Pankaj J Pasricha
    Division of Gastroenterology and Hepatology, Stanford University, Stanford, California 94305 5187, USA
    Gastrointest Endosc 70:1231-7. 2009
    ..Sphincter function is a common problem in gastroenterology and leads to disorders such as GERD and fecal incontinence...
  88. ncbi Prokinetic therapy in gastroesophageal reflux disease
    M C Champion
    Ottawa Civic Hospital, Ontario
    Can J Gastroenterol 11:55B-65B. 1997
    ..The key factor in the pathogenesis of GERD is disordered function of the lower esophageal sphincter. Other factors include delayed gastric emptying and decreased peristalsis in the body of the esophagus...
  89. ncbi Cisapride decreases gastroesophageal reflux in preterm infants
    R L Ariagno
    Department of Pediatrics, Stanford University, Palo Alto, California 94304 1510, USA
    Pediatrics 107:E58. 2001
    ..are commonly used in pediatric practice to improve gastric emptying, to decrease emesis, to improve lower esophageal sphincter tone, and to improve irritability and feeding aversion associated with gastroesophageal reflux (GER)...
  90. ncbi Initial experience with the stretta procedure for the treatment of gastroesophageal reflux disease
    W O Richards
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2577, USA
    J Laparoendosc Adv Surg Tech A 11:267-73. 2001
    ..It can be used for the endoscopic treatment of gastroesophageal reflux disease (GERD)...
  91. ncbi Total gastrectomy reconstructed by interposition of a jejunal J pouch with preservation of hepatic vagus branch and lower esophageal sphincter for T2 gastric cancer without lymph node metastasis
    Ryouichi Tomita
    Department of Surgery, Nippon Dental University School of Dentistry, Tokyo, Japan
    Hepatogastroenterology 51:1233-40. 2004
    ..lymph node metastasis, which mainly locates in the middle third of stomach, we have performed a total gastrectomy preserving both hepatic vagus branches and the lower esophageal sphincter as a function-preserving surgical procedure.
  92. ncbi Esophageal striated muscle contractions in patients with Chagas' disease and idiopathic achalasia
    R O Dantas
    Departamento de Clinica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 35:677-83. 2002
    ..of the number of intrinsic neurons of the esophageal myenteric plexus, with consequent absent or partial lower esophageal sphincter relaxation and loss of peristalsis in the esophageal body...
  93. ncbi Association between medications that relax the lower esophageal sphincter and risk for esophageal adenocarcinoma
    J Lagergren
    Karolinska Institutet and Danderyd Hospital, Stockholm, Sweden
    Ann Intern Med 133:165-75. 2000
    ..adenocarcinoma coincided with the introduction of medications that promote reflux by relaxing the lower esophageal sphincter (LES), such as nitroglycerin, anticholinergics, beta-adrenergic agonists, aminophyllines, and ..
  94. ncbi Effect of proximal gastric volume on hiatal hernia
    R C H Scheffer
    Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Neurogastroenterol Motil 22:552-6, e120. 2010
    Spatial separation of the diaphragm and the lower esophageal sphincter (LES) occurs frequently and intermittently in patients with a sliding hiatus hernia and favors gastro-esophageal reflux...
  95. ncbi Subtypes of muscarinic receptors in vagal inhibitory pathway to the lower esophageal sphincter of the opossum
    R J Gilbert
    Department of Pharmacology, Medical College of Wisconsin, Milwaukee 53226
    Dig Dis Sci 32:1130-5. 1987
    We assessed the characteristics of muscarinic neural transmission in the vagal inhibitory pathway to the lower esophageal sphincter (LES) of anesthetized opossums. LES relaxation was induced by electrical stimulation of the cervical vagus...
  96. ncbi Return of esophageal function after treatment for achalasia as determined by impedance-manometry
    Roger P Tatum
    Department of Surgery, University of Washington, VA Puget Sound HCS, 1660 S Columbian Way, s 112 gs, Seattle, WA 98108, USA
    J Gastrointest Surg 11:1403-9. 2007
    Treatment for achalasia is aimed at the lower esophageal sphincter (LES), although little is known about the effect, if any, of these treatments on esophageal body function (peristalsis and clearance)...
  97. ncbi Intravenous anesthetics inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation via nitric oxide-cyclic guanosine monophosphate pathway modulation in rabbits
    A Kohjitani
    Department of Dental Anesthesiology, Okayama University School of Dentistry, Japan
    Anesthesiology 95:176-83. 2001
    Nonadrenergic noncholinergic (NANC) nerves have important roles in the regulation of the lower esophageal sphincter (LES) motility and function. The effects of thiopental, ketamine, and midazolam on NANC LES relaxation were investigated.
  98. ncbi Peppermint oil improves the manometric findings in diffuse esophageal spasm
    M Pimentel
    GI Motility Program, Department of Medicine, Cedars Sinai Medical Center, CSMC Burns and Allen Research Institute, 8700 Beverly Boulevard, Los Angeles, CA 90048, U S A
    J Clin Gastroenterol 33:27-31. 2001
    ..Current medical treatment of DES is frequently unsatisfactory. We hypothesized that, as a smooth muscle relaxant, peppermint oil may improve the manometric findings in DES...
  99. pmc Defining GERD
    S J Sontag
    VA Hospital, Hines, Illinois, USA
    Yale J Biol Med 72:69-80. 1999
    ..Hypothesis 1: congenital. The antireflux barrier, comprising the smooth-muscled lower esophageal sphincter, the skeletal-muscled right crural diaphragm and the phreno-esophageal ligament does not completely ..
  100. ncbi Pharyngeal dilation in cricopharyngeus muscle dysfunction and Zenker diverticulum
    Peter C Belafsky
    Center for Voice and Swallowing, University of California, Davis School of Medicine, Department of Otolaryngology HNS, Sacramento, California, USA
    Laryngoscope 120:889-94. 2010
    Prolonged obstruction at the level of the lower esophageal sphincter is associated with a dilated, poorly contractile esophagus...
  101. ncbi Calcium carbonate antacids alter esophageal motility in heartburn sufferers
    Sheila Rodriguez-Stanley
    Oklahoma Foundation for Digestive Research, Oklahoma City, Oklahoma 73104, USA
    Dig Dis Sci 49:1862-7. 2004
    ..Subjects with hypertensive esophageal contractions or hypertensive lower esophageal sphincter pressure (LESP) were excluded. Subjects with normal to low LESP were included...

Research Grants39

  1. Mechanosensory Motor Neurons of Lower Esophageal Sphincter
    Ravinder K Mittal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Introduction: Impaired lower esophageal sphincter (LES) relaxation is the hallmark of achalasia and other spastic motor disorders of the esophagus...
  2. Obstruction-initiated mechanotranscription in colonic smooth muscle cells
    Xuan Zheng Shi; Fiscal Year: 2012
    ..stretch-related motility disorders such as achalasia and gastroparesis, where lack of relaxation of lower esophageal sphincter and pylorus sphincter is associated with distension and hypomotility in the esophageal body and antrum, ..
  3. Simple &Safe Implantable Device for Treatment of Gastroesophageal Reflux Disease
    CLAUDE NMN TIHON; Fiscal Year: 2013
    ..They aim to achieve the same objective as surgery in increasing the constraints of the lower esophageal sphincter (LES)...
  4. THE DIAPHRAGM--AN EXTERNAL LOWER ESOPHAGEAL SPHINCTER
    RAVINDER MITTAL; Fiscal Year: 1993
    ..suggested that this pressure resulted exclusively from the tonic activity of the smooth muscles of the lower esophageal sphincter (LES)...
  5. NEUROPEPTIDE CONTROL OF ENTERIC SPHINCTERS
    James Reynolds; Fiscal Year: 1990
    ..Our work determining neuropeptide sequences in the activation of the lower esophageal sphincter responses to acid and the pyloric responses to intraluminal nutrients suggests that Sphincteric reflexes ..
  6. ESOPHAGEAL RECEPTOR REFLEXES: BRAINSTEM CIRCUITRY
    STEVEN ALTSCHULER; Fiscal Year: 1991
    ..Studies indicate that the crural diaphragm and the intrinsic lower esophageal sphincter are important to the genesis of the high pressure zone, and that both muscles act in concert to form the ..
  7. EVALUATION OF RISK FACTORS FOR BARRETT'S ESOPHAGUS
    Douglas Corley; Fiscal Year: 2001
    ..People with Barrett's metaplasia have different intakes of fats and medications that relax the lower esophageal sphincter (e.g. calcium channel blockers, beta-agonists, anticholinergic agents) than do controls. B...
  8. PHYSIOLOGY & PATHOPHYSIOLOGY OF ESOPHAGEAL MOTILITY
    Raj Goyal; Fiscal Year: 1993
    ..of this research proposal are: (1) to elucidate the physiology of (a) esophageal peristalsis and (b) lower esophageal sphincter (LES) tone and relaxation; (2) to identify the nature of the neurotransmitters involved in esophageal ..
  9. DEVELOPMENTAL ASPECTS OF UPPER GASTROINTESTINAL MOTILITY
    A Hillemeier; Fiscal Year: 1990
    ..studies to evaluate the effect of age on: a) Maintenance and modulation of upper esophageal sphincter, lower esophageal sphincter tone and relaxation, and esophageal peristalsis...
  10. NOVEL ESOPHAGEAL MOTOR FUNCTION ASSESSMENT SYSTEM
    JianFeng Chen; Fiscal Year: 2006
    ..of such an assessment system with the following specific aims: Aim 1: Automated localization of the lower esophageal sphincter and interactive data acquisition; Aim 2: The removal of respiratory artifacts in the LES pressure ..
  11. Redefinition of Gastroesophageal Reflux in Children
    Hayat Mousa; Fiscal Year: 2004
    The prolonged measurement of the pH values close to the lower esophageal sphincter (LES) is considered the "gold standard" in the diagnosis of gastroesophageal reflux (GER). A pH below 4.0 is considered indicative of GER...
  12. LASER CATHETER FOR TREATMENT OF GASTROESOPHAGEAL REFLUX
    Ashok Gowda; Fiscal Year: 2001
    ..Gastroesophageal reflux disease (GERD) is a physical condition resulting from an inability of the lower esophageal sphincter (LES) to prevent reflux of stomach acids into the esophagus...
  13. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
    ..To date, much of the research on the competence of the EGJ in GERD has been focused on the lower esophageal sphincter. Our hypothesis is that acquired anatomic changes inclusive of, but not restricted to hiatal hernia may ..
  14. PHARYNGEAL RECEPTORS AND REFLUX DISEASE
    RAVINDER MITTAL; Fiscal Year: 2001
    ..DESCRIPTION: Traditional view holds that gastroesophageal reflux is the consequence of a persistently weak lower esophageal sphincter. Several investigators over the last decade have found that most reflux events, during brief ..
  15. ROLE OF PUBORECTALIS MUSCLE IN FECAL CONTINENCE
    RAVINDER MITTAL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  16. AUTONOMIC CONTROL OF BODY WEIGHT AND FEEDING
    TERRY POWLEY; Fiscal Year: 2006
    ..abstract_text> ..
  17. PURDUE INTEGRATIVE NEUROSCIENCE PROGRAM
    TERRY POWLEY; Fiscal Year: 2002
    ..Students trained in the interdisciplinary Purdue Integrative Neuroscience program will make substantial contributions to mental health research and its applications in the next century. ..
  18. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
  19. PHYSIOLOGY AND PATHOPHYSIOLOGY OF ESOPHAGEAL MOTILITY
    Raj Goyal; Fiscal Year: 2002
    ..The effects of NO on single cells will be relate to nitrergic neurotransmission and physiology with microelectrode, mechanical studies and measurement of esophageal motility in vivo. ..
  20. Research Symposium on Functional Abdoninal Pain in Children
    Samuel Nurko; Fiscal Year: 2007
    ..7. To educate the NASPGHAN membership on the state of the art of functional abdominal pain and IBS in children. [unreadable] [unreadable] [unreadable]..
  21. PLACEBO CONTROLLED STUDY OF BACLOFEN FOR GERD IN CHILDREN WITH CEREBRAL PALSY
    Samuel Nurko; Fiscal Year: 2008
    ..a high failure rate in children with CP, presumably because they do not affect the rate of transient lower esophageal sphincter relaxations (TLESRs) and do not control or may increase the presence of non-acid reflux...
  22. THE HIGH PRESSURE ZONE OF THE DISTAL ESOPHAGUS
    Larry Miller; Fiscal Year: 2006
    ..Abstract): The PI's hypothesis is that the crural diaphragm interacts with the intrinsic lower esophageal sphincter in a very complex manner...
  23. New Approach to Detect CP and Brain Injury by Term Age
    RONALD ARIAGNO; Fiscal Year: 2003
    ..It is essential to discover a new approach to identify brain injury early, before it will be possible to effectively investigate interventions that can improve neurological outcome of these high risk very premature infants. ..
  24. Novel direct vago-vagal recording of i.v. ghrelin action
    David Adelson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  26. BIOPHYSICAL PRINCIPLES OF PERISTALTIC PHENOMENA
    Piero Biancani; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Disorders of esophageal motor function and Lower Esophageal Sphincter (LES) competence affect more than one in ten adults over 40 and one in four adults over 60 years of age...
  27. Comparison of Two Therapies for UES Dysphagia
    Reza Shaker; Fiscal Year: 2004
    ..anteroposterior and lateral diameter of maximum deglutitive UES opening, and b. maximum deglutitive laryngeal anterior and superior excursions. ..
  28. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
    ..These methods will be employed pre- and post-therapy on all patients to assess their potential clinical utility, especially in those unresponsive to medical therapy after aggressive acid suppression. ..
  29. MII to characterize reflux in Barrett's esophagus
    Donald Castell; Fiscal Year: 2005
    ....
  30. Quantitative Approach to Analysis of Cortical Dynamics
    Hualou Liang; Fiscal Year: 2005
    ..abstract_text> ..