Genomes and Genes
lower esophageal sphincter
Summary: The physiologic or functional barrier to GASTROESOPHAGEAL REFLUX at the esophagogastric junction. Sphincteric muscles remain tonically contracted during the resting state and form the high-pressure zone separating the lumen of the ESOPHAGUS from that of the STOMACH. (Haubrich et al, Bockus Gastroenterology, 5th ed., pp399, 415)
Publications224 found, 100 shown here
- Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometryJohn E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Gastroenterology 131:1725-33. 2006..was to perform a detailed analysis of the mechanics leading to esophagogastric junction (EGJ) opening during transient lower esophageal sphincter relaxations (tLESRs) using high-resolution manometry coupled with simultaneous fluoroscopy.
- A unique longitudinal muscle contraction pattern associated with transient lower esophageal sphincter relaxationArash Babaei
Division of Gastroenterology, San Diego VA Health Care System and University of California, San Diego, California
Gastroenterology 134:1322-31. 2008..of the longitudinal muscle of the esophagus may play a role in the relaxation and opening of the lower esophageal sphincter (LES)...
- Obesity and gastroesophageal reflux: quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptomsShahin Ayazi
Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St, Ste 514, Los Angeles, CA 90033, USA
J Gastrointest Surg 13:1440-7. 2009..The aim of this study is to quantify the relationship between body mass index (BMI) and 24-h esophageal pH measurements and the status of the lower esophageal sphincter (LES) in patients with reflux symptoms.
- Manometric changes of the lower esophageal sphincter after sleeve gastrectomy in obese patientsItalo Braghetto
Department of Surgery, Faculty of Medicine, University of Chile, Santos Dumont 999, Santiago, Chile
Obes Surg 20:357-62. 2010..Laparoscopic sleeve gastrectomy has been accepted as an option for surgical treatment of obesity. After surgery, some patients present reflux symptoms associated with endoscopic esophagitis, therefore PPI's treatment must be indicated...
- The impact of continuous positive airway pressure on the lower esophageal sphincterKelly L Shepherd
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
Am J Physiol Gastrointest Liver Physiol 292:G1200-5. 2007The lower esophageal sphincter (LES) is the primary barrier to gastroesophageal reflux. Reflux is associated with periods of LES relaxation, as occurs during swallowing...
- Effects of dexmedetomidine and propofol on lower esophageal sphincter and gastroesophageal pressure gradient in healthy volunteersAlparslan Turan
Department of Outcomes Research, The Cleveland Clinic, Cleveland, OH 44195, USA
Anesthesiology 112:19-24. 2010Many anesthetics reduce lower esophageal sphincter pressure (LESP)...
- Dysfunction of the lower esophageal sphincter and dysmotility of the tubular esophagus in morbidly obese patientsM A Küper
Department of General, Visceral, and Transplant Surgery, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
Obes Surg 19:1143-9. 2009..Morbid obesity is associated with gastroesophageal reflux (GERD). The aim of this prospective study was to determine esophageal motility in asymptomatic morbidly obese patients and compare it to non-obese individuals...
- An endoscopically implantable device stimulates the lower esophageal sphincter on demand by remote control: a study using a canine modelJ O Clarke
Johns Hopkins Hospital, Baltimore, Maryland, USA
Endoscopy 39:72-6. 2007..Selective stimulation to increase lower esophageal sphincter (LES) pressure may be useful in the control of gastroesophageal reflux disease...
- The effects of cricoid pressure, remifentanil, and propofol on esophageal motility and the lower esophageal sphincterKristian Thorn
Department of Anesthesiology and Intensive Care, Orebro University Hospital, 701 85 Orebro, Sweden
Anesth Analg 100:1200-3. 2005..purpose of this study was to investigate the effects of cricoid pressure, remifentanil, and propofol on lower esophageal sphincter (LES) and esophageal motility...
- Effect of lower esophageal sphincter distension and acidification on esophageal pressure and electromyographic activity: the identification of the "sphinctero-esophageal excitatory reflex"Ahmed Shafik
Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
Ann Thorac Surg 79:1126-31; discussion 1131. 2005..We investigated the hypothesis that lower esophageal sphincter (LES) dilatation rather than the refluxed acid affected reflex increase in the esophageal peristaltic ..
- Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincterYanFen Jiang
Division of Gastroenterology, San Diego Veterans Affairs Healthcare System and University of California, San Diego, San Diego, California 92161, USA
Am J Physiol Gastrointest Liver Physiol 297:G397-405. 2009..found that an orally directed stretch of the esophagus activates a neurally mediated relaxation of the lower esophageal sphincter (LES)...
- Neurotransmission in lower esophageal sphincter of W/Wv mutant miceY Zhang
Division of Gastroenterology, Hotel Dieu Hospital, 166 Brock St, Kingston, Ontario K7L5G2, Canada
Am J Physiol Gastrointest Liver Physiol 298:G14-24. 2010..ICC) in nitrergic neurotransmission to gastrointestinal smooth muscle, circular smooth muscle from the lower esophageal sphincter (LES) of W/W(v) wild-type and mutant (ICC-deficient) mice were studied by using intracellular and ..
- Barrett's esophagus and medications that relax the lower esophageal sphincterDouglas A Corley
Northern California Kaiser Permanente Division of Research, Oakland 94612, USA
Am J Gastroenterol 101:937-44. 2006..We evaluated patients with a high-risk condition, Barrett's esophagus, to identify risk factors that may act early in the carcinogenic process...
- Obesity is associated with increased transient lower esophageal sphincter relaxationJustin Che Yuen Wu
Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
Gastroenterology 132:883-9. 2007..We evaluated the association between obesity and function of lower esophageal sphincter (LOS) in subjects without GERD.
- Transient lower esophageal sphincter relaxations in dogs are inhibited by a metabotropic glutamate receptor 5 antagonistJorgen Jensen
AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
Eur J Pharmacol 519:154-7. 2005Transient lower esophageal sphincter relaxation is the major mechanism for gastroesophageal reflux...
- Novel treatments of GERD: focus on the lower esophageal sphincterA Lehmann
Bioscience, AstraZeneca R and D, Molndal, Sweden
Eur Rev Med Pharmacol Sci 12:103-10. 2008..The lower esophageal sphincter (LES) plays a crucial role in maintaining the mechanical barrier necessary for prevention of gastric ..
- Manometric study of lower esophageal sphincter in children with primary acid gastroesophageal reflux and acid gastroesophageal reflux secondary to food allergyJ Semeniuk
III Department of Pediatrics, Medical University of Bialystok, Bialystok, Poland
Adv Med Sci 53:283-92. 2008The comparison of values of selected lower esophageal sphincter (LES) manometric parameters measured in children suspected of gastroesophageal reflux disease (GERD) (preliminary study) and in children with primary acid GER and acid GER ..
- (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of actionAnders Lehmann
AstraZeneca R and D, Molndal, Sweden
J Pharmacol Exp Ther 331:504-12. 2009..We describe a new therapeutic approach for GERD, based on inhibition of transient lower esophageal sphincter relaxation (TLESR) with a proposed peripherally acting GABA(B) receptor agonist, (R)-(3-amino-2-..
- Gastroesophageal reflux disease and obesity. Pathophysiology and implications for treatmentFernando A M Herbella
Department of Surgery, University of California San Francisco, CA 94143 0790, USA
J Gastrointest Surg 11:286-90. 2007..in morbidly obese (body mass index (BMI) > or =35) and nonmorbidly patients (BMI <35) with GERD: (a) lower esophageal sphincter (LES) profile; (b) esophageal body function; and (c) esophageal acid exposure...
- Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus toneMark Niedringhaus
Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
Am J Physiol Regul Integr Comp Physiol 294:R121-31. 2008..of our study were to determine the CNS site that controls the CD and whether simultaneous changes in lower esophageal sphincter (LES) pressure and CD activity occur when this site is activated...
- Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitisLing Cheng
Division of Gastroenterology, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
Gastroenterology 129:1675-85. 2005We have previously used the normal lower esophageal sphincter (N-LES) of human organ donors to examine the physiologic signal transduction of lower esophageal sphincter (LES) circular muscle...
- Presence of GABA(B) receptors forming heterodimers with GABA(B1) and GABA(B2) subunits in human lower esophageal sphincterYasuhiro Torashima
Division of Surgery, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
J Pharmacol Sci 111:253-9. 2009..for the management of gastro-esophageal reflux disease, but whether the compound acts directly at the lower esophageal sphincter (LES) remains to be elucidated...
- The effects on the lower esophageal sphincter of sevoflurane induction and increased intra-abdominal pressure during laparoscopyK Thorn
Department of Anesthesiology and Intensive Care, Orebro University Hospital, Orebro, Sweden
Acta Anaesthesiol Scand 50:978-81. 2006..patients was to investigate the effects of sevoflurane during inhalation induction on the lower esophageal sphincter pressure (LESP) and barrier pressure (BrP)...
- Transient lower esophageal sphincter relaxations do not result from passive opening of the cardia by gastric distentionBenson T Massey
Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Gastroenterology 130:89-95. 2006Transient lower esophageal sphincter relaxation is the main mechanism for gastroesophageal reflux...
- Lower esophageal sphincter pressure in patients with gastroesophageal reflux diseases and posture and time patternsA Meining
Department of Medicine, Klinikum Innenstadt, University of Munich, Germany
Dis Esophagus 17:155-8. 2004Gastroesophageal reflux disease is caused predominantly by lower esophageal sphincter insufficiency...
- Response of the lower esophageal sphincter to gastric distention by carbonated beveragesNahid Hamoui
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
J Gastrointest Surg 10:870-7. 2006Gastroesophageal reflux disease often occurs in patients with normal resting pressure and length of the lower esophageal sphincter. Such patients often have postprandial reflux. The mechanism of postprandial reflux remains controversial...
- The value of high-resolution manometry in the assessment of the resting characteristics of the lower esophageal sphincterShahin Ayazi
Division of Thoracic and Foregut Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA, USA
J Gastrointest Surg 13:2113-20. 2009..There has been less emphasis on the use of HRM to evaluate the lower esophageal sphincter (LES) resting pressure and length, both factors important in LES barrier function...
- Transient lower esophageal sphincter relaxation in morbid obesityJ H Schneider
Department of General, Visceral and Transplant Surgery, University Hospital of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
Obes Surg 19:595-600. 2009..Gastroesophageal reflux is caused predominantly by transient lower esophageal sphincter relaxations (TLESRs)...
- Upper esophageal sphincter during transient lower esophageal sphincter relaxation: effects of reflux content and postureArash Babaei
University of California, San Diego, USA
Am J Physiol Gastrointest Liver Physiol 298:G601-7. 2010Although some studies show that the upper esophageal sphincter (UES) contracts during transient lower esophageal sphincter relaxation (TLESR), others show that it relaxes...
- Apnea-associated reduction in lower esophageal sphincter tone in premature infantsTaher I Omari
Gastroenterology Unit, Children, Youth and Women s Health Services, North Adelaide, Australia
J Pediatr 154:374-8. 2009..To characterize esophageal motility during episodes of prolonged apnea in premature infants...
- Inhibition of transient lower esophageal sphincter relaxations by electrical acupoint stimulationDuowu Zou
Dept of Gastroenterology, Hepatology, and General Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
Am J Physiol Gastrointest Liver Physiol 289:G197-201. 2005..Gastric distension is the major trigger for transient lower esophageal sphincter (LES) relaxations (TLESRs)...
- The role of transsphincteric pressure and proximal gastric volume in acid reflux before and after fundoplicationRobert C H Scheffer
Gastrointestinal Research Unit, Department of Gastroenterology and Department of Surgery, University Medical Center, Utrecht, The Netherlands
Gastroenterology 129:1900-9. 2005..the role of proximal gastric volume and transsphincteric pressure on acid reflux during transient lower esophageal sphincter relaxation (TLESR) in patients with gastroesophageal reflux disease (GERD) both before and after ..
- Lower oesophageal sphincter pressure and timed barium oesophagogram: two objective parameters in the non-invasive assessment of primary achalasiaG Montazeri
Gastroenterology and Hepatology, Digestive Disease Research Center, Tehran University of Medical Science, Shariati Hospital, Tehran, Iran
Aliment Pharmacol Ther 22:261-5. 2005..The non-invasive assessment of primary achalasia is not precise...
- The real value of lower esophageal sphincter measurement for predicting acid gastroesophageal reflux or Barrett's esophagusOscar Alonso
Department of Surgery and Abdominal Organ Transplantation, 12 de Octubre University Hospital, Madrid, Spain
J Gastrointest Surg 9:973-9. 2005The study goal was to ascertain the true value of lower esophageal sphincter measurement in order to establish the risk of presenting gastroesophageal reflux or Barrett's esophagus...
- [Effects of two test-meals on transient lower esophageal sphincter relaxation in patients with gastroesophageal reflux disease and mechanism of gastroesophageal reflux]Xiao Hong Sun
Department of Gastroenterology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26:628-33. 2004To investigate the effects of standard meal and fat meal distending the fundus on transient lower esophageal sphincter relaxation (TLESR) and esophageal motility and to explore the mechanism of gastroesophageal reflux (GER) in patients ..
- Structure and function of the esophagus of the American alligator (Alligator mississippiensis)T J Uriona
Department of Biology, 257 South 1400 East, University of Utah, Salt Lake City, UT 84112, USA
J Exp Biol 208:3047-53. 2005..We observed a large increase in pressure in the lower esophageal sphincter (LES) during ventilation that ranged from 200% to 3000% of the pressures measured during apnea...
- Transient lower esophageal sphincter relaxations (TLESRs) are the major mechanism of gastroesophageal reflux but are not the cause of reflux diseaseKatsuhiko Iwakiri
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
Dig Dis Sci 50:1072-7. 2005In healthy subjects, the rate of acid reflux during transient lower esophageal sphincter relaxations (TLESRs) is more frequent at the proximal margin of the LES...
- Surgical treatment of achalasia: current status and controversiesFarshad Abir
Department of Surgery, Yale University School of Medicine, New Haven, Conn 06520 8062, USA
Dig Surg 21:165-76. 2004..To review the current management of achalasia, and the controversies regarding the different treatment options...
- Gastric electrical stimulation (GES) with parameters for morbid obesity elevates lower esophageal sphincter (LES) pressure in conscious dogsJ H Xing
Veterans Research Foundation, VAMC, Oklahoma City, OK, and Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX 77555 0632, USA
Obes Surg 15:1321-7. 2005..Treatment of obese patients with the implantable gastric stimulator (IGS) was reported to improve reflux symptoms, independent of weight loss. We evaluated the effect of gastric electrical stimulation on LES pressure in conscious dogs...
- Esophageal manometric changes and gastroesophageal reflux symptoms after distal gastrectomy for gastric cancerNorihiro Haga
Department of Surgery, Gunma Cancer Center, Ota, Japan
Hepatogastroenterology 52:310-3. 2005..However, its mechanism is not completely understood. We investigated the effects of distal gastrectomy for gastric cancer on the lower esophageal sphincter (LES) and esophageal motility.
- Pneumatic balloon dilatation in primary achalasia: the long-term follow-up resultsGungor Boztas
Department of Internal Medicine, Gastroenterology Division, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Hepatogastroenterology 52:475-80. 2005..Pneumatic dilatation is a safe and most effective treatment for achalasia. We analyzed the long-term results of pneumatic dilatation in primary achalasia by objective and subjective findings...
- Postprandial water intake inhibits gastric antral motility with increase of cholecystokinin in humansMotoyasu Kusano
Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Japan
Scand J Gastroenterol 40:1176-81. 2005..The effects of postprandial water intake on the gastrointestinal tract have not been systematically investigated in humans...
- Reproducibility of meal-induced transient lower oesophageal sphincter relaxations in patients with gastro-oesophageal reflux diseaseG E Boeckxstaens
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
Neurogastroenterol Motil 17:23-8. 2005....
- Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitisDenesh K Chitkara
The Motility Unit, Division of Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, Boston, MA 02111, USA
J Pediatr Gastroenterol Nutr 40:70-5. 2005..To evaluate esophageal body motor contractions occurring during esophageal reflux in pediatric patients with gastro-esophageal reflux disease (GERD)...
- Abnormal acid reflux in asthmatic patients in a region with low GERD prevalenceJen Yuan Hsu
Division of Chest Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
J Gastroenterol 40:11-5. 2005..However, only a few data from Asia are available. This study evaluated the incidence of abnormal gastroesophageal reflux (GER) in asthmatic patients in Taiwan...
- Pathophysiology of gastroesophageal reflux diseases in Chinese--role of transient lower esophageal sphincter relaxation and esophageal motor dysfunctionWai Man Wong
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
Am J Gastroenterol 99:2088-93. 2004Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism for gastroesophageal reflux in the Western population. The major reflux mechanism in Chinese patients with GERD has not been studied before.
- Manometric evaluation of achalasia in the elderlyN Hashemi
Division of Gastroenterology and Hepatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107 5244, USA
Aliment Pharmacol Ther 21:431-4. 2005..The effect of ageing on oesophageal motility in patients with achalasia is not well described. Oesophageal contraction amplitude is decreased in otherwise healthy elderly subjects...
- Preoperative esophageal manometry does not predict postoperative dysphagia following anti-reflux surgeryS J Cole
Department of Surgery, University of Pretoria, Pretoria, South Africa
Dis Esophagus 18:51-6. 2005..In conclusion, preoperative manometry does not predict postoperative dysphagia following laparoscopic Toupet partial fundoplication...
- Relationships among nocturnal jaw muscle activities, decreased esophageal pH, and sleep positionsShouichi Miyawaki
Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
Am J Orthod Dentofacial Orthop 126:615-9. 2004..These results suggest that most jaw muscle activities, ie, RMMA, single short-burst, and clenching episodes, occur in relation to gastroesophageal reflux mainly in the supine position...
- Gastro-oesophageal reflux disease in infants and children: new insights, developments and old chestnutsTaher Omari
Centre for Pediatric and Adolescent Gastroenterology, Women s and Children s Hospital, North Adelaide, Australia
J Pediatr Gastroenterol Nutr 41:S21-3. 2005
- Clinical, radiographic, and manometric evolution of esophageal involvement by Chagas' diseaseUlysses G Meneghelli
Departamento de Clinica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Ribeirao Preto, Brazil
Dysphagia 20:40-5. 2005..of esophageal Chagas' disease includes nonperistaltic contractions in the esophageal body, absent lower esophageal sphincter (LES) relaxation, and dilatation of the organ...
- Lower esophageal sphincter analysis using computerized manometry in patients with chagasic megaesophagusC G Andrade
Department of Gastroenterology, University of Sao Paulo Medical School, Sao Paulo, Brazil
Dis Esophagus 19:31-5. 2006..of computer technology into manometry laboratories, three-dimensional manometric images of the lower esophageal sphincter can be constructed based on radially oriented pressures, a method termed 'computerized axial manometry...
- Gastroesophageal and pharyngeal reflux detection using impedance and 24-hour pH monitoring in asymptomatic subjects: defining the normal environmentBrant K Oelschlager
Swallowing Center, Department of Surgery, University of Washington, Seattle, 98195, USA
J Gastrointest Surg 10:54-62. 2006..Most reflux episodes (348 of 496) reached the mid esophagus (9 cm above lower esophageal sphincter). There were 51 reflux episodes that reached the pharynx (PR)...
- New observations on the gastroesophageal antireflux barrierLarry Miller
Department of Gastroenterology, Temple University Hospital, Gastroenterology Section, 8th Floor, Parkinson Pavilion, Philadelphia, PA 19043, USA
Gastroenterol Clin North Am 36:601-17, ix. 2007....
- The lower esophageal sphincter strength in patients with gastroesophageal reflux before and after laparoscopic Nissen fundoplicationJ H Schneider
Department of Visceral Surgery and Transplantation of University of Tübingen, Tubingen, Germany
Dis Esophagus 20:58-62. 2007b>Lower esophageal sphincter pressure (LESP) and sphincter strength (LESS) were measured before and after short and floppy laparoscopic Nissen fundoplication (LNF) in 38 patients with severe gastro-esophageal reflux disease (GERD)...
- The effect of laparoscopic partial fundoplication on dysphagia, esophageal and lower esophageal sphincter motilityM Y A Lindeboom
Department of Gastroenterology Hepatology, Leiden University Medical Center, Leiden, The Netherlands
Dis Esophagus 20:63-8. 2007..Symptoms, lower esophageal sphincter (LES) characteristics and esophageal body motility were evaluated prospectively in 62 patients before ..
- High-resolution manometry and impedance-pH/manometry: valuable tools in clinical and investigational esophagologyPeter J Kahrilas
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
Gastroenterology 135:756-69. 2008..Ultimately, however, both technologies will be strengthened as outcome studies evaluating their utilization become available...
- Esophageal motility disorders in the morbidly obese populationJ S Koppman
The Bariatric Institute and Section of Minimally Invasive Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA
Surg Endosc 21:761-4. 2007..investigating esophageal motility among the morbidly obese have focused on the relationship between lower esophageal sphincter (LES) pressure and gastroesophageal reflux disease (GERD)...
- Heller-type cardiomyotomy using NOTESA Mathew
Endoscopy 40:352. 2008
- Is aperistalsis with complete lower esophageal sphincter relaxation an early stage of classic achalasia?Jeong Hwan Kim
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
J Gastroenterol Hepatol 22:536-41. 2007Aperistalsis with complete lower esophageal sphincter (LES) relaxation, characterized by the complete relaxation of the LES and aperistalsis of the esophageal body on manometry, has been considered by some authors to be an early ..
- Mechanisms of gastroesophageal reflux in children with sequelae of birth asphyxiaLicia Pensabene
Department of Pediatrics, University Magna Graecia of Catanzaro, Italy
Brain Dev 30:563-71. 2008..When the rate of decrease of lower esophageal sphincter (LES) pressure was >1 mmHg/s, the decrease of LES pressure was defined as LES relaxation...
- Evidence for the ''paradox'' association between hypertensive lower esophageal sphincter and gastroesophageal reflux diseaseG Kouklakis
Medical School, Democritus University of Thrace Alexandroupolis, Greece
Minerva Gastroenterol Dietol 54:97-100. 2008..Manometry revealed a hypertensive lower esophageal sphincter pressure (resting pressure 35 mmHg) and pHmetry revealed a DeMeester score > 14.72 (43.27)...
- Endoscope-guided pneumatic dilatation of esophageal achalasia without fluoroscopy is another safe and effective treatment option: a report of TaiwanSeng Kee Chuah
Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
Surg Laparosc Endosc Percutan Tech 18:8-12. 2008..Thirty-three patients were treated, excellent results in 27, good results in 3, and failure in 3 (1 requiring surgical treatment later). Overall, we demonstrated that the technique is effective and safe option for achalasia treatment...
- High-resolution manometryA J Bredenoord
Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
Dig Liver Dis 40:174-81. 2008..Further studies will have to determine whether high-resolution manometry is superior to conventional manometry in the diagnostic work-up of patients with oesophageal symptoms...
- Laparoscopic partial posterior (Toupet) fundoplication improves esophageal bolus propagation on scintigraphyH Wykypiel
Department of General and Transplant Surgery, Medical University, Anichstrasse 35, A 6020, Innsbruck, Austria
Surg Endosc 22:1845-51. 2008..The aim of this study was to investigate the effect of laparoscopic Nissen fundoplication (NF), laparoscopic partial posterior (Toupet) fundoplication (PPF) or medical therapy on esophageal clearance...
- Effect of laparoscopic fundoplication on hypertensive lower esophageal sphincter associated with gastroesophageal refluxGabor Varga
Department of Surgery, Medical School, University of Pecs, Pecs, Hungary
J Gastrointest Surg 12:304-7. 2008For hypertensive lower esophageal sphincter with dysphagia and chest pain, a laparoscopic cardiomyotomy is recommended. Recently, the role of gastroesophageal reflux in this abnormality has been recognized...
- Submucosal endoscopic esophageal myotomy: a novel experimental approach for the treatment of achalasiaP J Pasricha
Divison of Gastroenterology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 0764, USA
Endoscopy 39:761-4. 2007..We hypothesized that we could perform a safe and robust myotomy by working in the submucosal space, accessed from the esophageal lumen...
- Long-term results of conventional myotomy in patients with achalasia: a prospective 20-year analysisInes Gockel
Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, and the Department of Gastroenterology, German Diagnostic Clinic, Wiesbaden, Germany
J Gastrointest Surg 10:1400-8. 2006..4 (range, 1-10) mm to 10 (range, 5-15) mm. The resting pressure of the lower esophageal sphincter could be reduced from 28.4 (range, 9.4-56.0) mm Hg to 8.6 (range, 3.0-22.5) mm Hg...
- [Functional changes in the cardioesophageal region following laparoscopic fundoplication]M Lovecek
I Chirurgická klinika FN Olomouc
Rozhl Chir 87:237-41. 2008..Functional changes of antireflux mechanisms after laparoscopic fundpolication...
- Endoscopic findings around the gastroesophageal junction: an experience from a tertiary hospital in KoreaJi Hyun Kim
Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea
Korean J Intern Med 23:127-33. 2008..This study examined the distribution of endoscopic findings around the GEJ and elucidated their relationship to each other and esophageal manometric features...
- Physiology of reflux disease: role of the lower esophageal sphincterP F Crookes
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Surg Endosc 20:S462-6. 2006The function of the lower esophageal sphincter (LES) has historically been elucidated by two major manometric methods: the one concentrating on static parameters including resting pressure, overall length, and intraabdominal length, and ..
- Does laparoscopic antireflux surgery prevent the occurrence of transient lower esophageal sphincter relaxation?F Bahmeriz
Department of Surgery, St Joseph s Healthcare, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
Surg Endosc 17:1050-4. 2003Transient lower esophageal sphincter relaxation (TLESR) is the most common mechanism underlying gastroesophageal reflux disease (GERD), causing 70% to 100% of the reflux episodes in normal subjects and 63% to 74% of the reflux episodes in ..
- Oesophagitis is common in patients with achalasia after pneumatic dilatationI Leeuwenburgh
Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands
Aliment Pharmacol Ther 23:1197-203. 2006..Treatment aims at lowering of the lower oesophageal sphincter pressure, enhancing the risk of gastro-oesophageal reflux. Nevertheless, the incidence of oesophagitis after achalasia treatment is unknown...
- Dor fundoplication after myotomy for achalasia: useful, unnecessary, or harmful?Venanzio Porziella
J Thorac Cardiovasc Surg 132:216-7; author reply 217. 2006
- Laparoscopic partial myectomy: an experimental reflux modelT P Hüttl
Department of Surgery, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
Surg Endosc 20:665-72. 2006..Due to the lack of an animal model of inadequate esophageal sphincter function, most experimental studies on antireflux procedures were done on normally functioning esophageal sphincters...
- Effect of an acute intraluminal administration of capsaicin on oesophageal motor pattern in GORD patients with ineffective oesophageal motilityL Grossi
Department of Medicine and Sciences of Aging, School of Gastroenterology, c o Unit of Medicine I, Ospedale Spirito Santo, G D Annunzio University of Chieti, Pescara, Italy
Neurogastroenterol Motil 18:632-6. 2006..Whether this could represent the basis for further therapeutic approaches of GORD patients needs further study...
- Gastro-oesophageal reflux of liquids and gas during transient lower oesophageal sphincter relaxationsA J Bredenoord
Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands
Neurogastroenterol Motil 18:888-93. 2006..We conclude that factors, other than TLOSR characteristics, are important of whether or not a TLOSR is reflux-related...
- New esophageal function testing (impedance, Bravo pH monitoring, and high-resolution manometry): clinical relevanceJason A Wilson
Division of Gastroenterology and Hepatology, Medical University of South Carolina, 25 Courtenay Drive, ART 7100A, MSC 290, Charleston, SC 29425, USA
Curr Gastroenterol Rep 10:222-30. 2008..The advantages, disadvantages, and clinical importance of these new esophageal tests are discussed in this review...
- Intraoperative manometry of the lower esophageal sphincter pressure during laparoscopic antireflux surgery with a mechanical calibration--early resultsZ Kala
Department of Surgery, Faculty Hospital Brno, Bohunice, Czech Republic
Hepatogastroenterology 53:710-4. 2006..An excessive increase of the intraoperative lower esophageal sphincter pressure (LESp) is supposed to be related to the persistent postoperative dysphagia and its knowledge ..
- Signal transduction in esophageal and LES circular muscle contractionK M Harnett
Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
Yale J Biol Med 72:153-68. 1999..In contrast, lower esophageal sphincter (LES) contraction induced by maximally effective doses of ACh is mediated by muscarinic M3 receptors, ..
- Does major depression in patients with gastroesophageal reflux disease affect the outcome of laparoscopic antireflux surgery?T Kamolz
Division of Clinical Psychology, Department of General Surgery, Public Hospital of Zell am See, Paracelsusstr 8, A 5700 Zell am See, Austria
Surg Endosc 17:55-60. 2003....
- Ketamine and midazolam differentially inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation in rabbits: role of superoxide anion and nitric oxide synthaseAtsushi Kohjitani
Department of Dental Anesthesiology, Okayama University Hospital of Dentistry, Shikata cho, Japan
Anesthesiology 98:449-58. 2003..reported that ketamine and midazolam inhibited nitric oxide-mediated nonadrenergic noncholinergic (NANC) lower esophageal sphincter (LES) relaxation nitric oxide-3',5'-cyclic guanosine monophosphate pathway modulation...
- Esophageal motility in patients with sliding hiatal hernia with reflux esophagitisPing Ye
Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Chin Med J (Engl) 121:898-903. 2008..The aim of the present study was to investigate the role of acid reflux and duodenal gastroesophageal reflux (DGER), esophageal manometry, and esophageal dysmotility by applying the barium meal examination...
- Esophageal manometric characteristics and outcomes for laparoscopic esophageal diverticulectomy, myotomy, and partial fundoplication for epiphrenic diverticulaLora Melman
Section of Minimally Invasive Surgery, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA
Surg Endosc 23:1337-41. 2009The purpose of this study is to characterize the esophageal motor and lower esophageal sphincter (LES) abnormalities associated with epiphrenic esophageal diverticula and analyze outcomes for laparoscopic esophageal diverticulectomy, ..
- An analysis of distal esophageal impedance in individuals with and without esophageal motility abnormalitiesWojciech Blonski
Division of Gastroenterology, Medical University of South Carolina, Charleston, SC 29425, USA
J Clin Gastroenterol 42:776-81. 2008..The aim of this study was to analyze and to compare distal esophageal impedance values between healthy volunteers and patients with normal and abnormal esophageal manometry...
- Effects of repeated administration of baclofen on transient lower esophageal sphincter relaxation in the dogA Lehmann
Gastrointestinal Pharmacology, AstraZeneca R and D Molndal, S 431 83, Molndal, Sweden
Eur J Pharmacol 403:163-7. 2000..gamma-aminobutyric acid (GABA) receptor (GABA(B) receptor) agonist baclofen inhibits transient lower esophageal sphincter relaxation in dogs, ferrets, and humans...
- Endoscopic injection of skeletal muscle-derived cells augments gut smooth muscle sphincter function: implications for a novel therapeutic approachPankaj J Pasricha
Division of Gastroenterology and Hepatology, Stanford University, Stanford, California 94305 5187, USA
Gastrointest Endosc 70:1231-7. 2009..Sphincter function is a common problem in gastroenterology and leads to disorders such as GERD and fecal incontinence...
- Prokinetic therapy in gastroesophageal reflux diseaseM C Champion
Ottawa Civic Hospital, Ontario
Can J Gastroenterol 11:55B-65B. 1997..The key factor in the pathogenesis of GERD is disordered function of the lower esophageal sphincter. Other factors include delayed gastric emptying and decreased peristalsis in the body of the esophagus...
- Cisapride decreases gastroesophageal reflux in preterm infantsR L Ariagno
Department of Pediatrics, Stanford University, Palo Alto, California 94304 1510, USA
Pediatrics 107:E58. 2001..are commonly used in pediatric practice to improve gastric emptying, to decrease emesis, to improve lower esophageal sphincter tone, and to improve irritability and feeding aversion associated with gastroesophageal reflux (GER)...
- Initial experience with the stretta procedure for the treatment of gastroesophageal reflux diseaseW O Richards
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2577, USA
J Laparoendosc Adv Surg Tech A 11:267-73. 2001..It can be used for the endoscopic treatment of gastroesophageal reflux disease (GERD)...
- Total gastrectomy reconstructed by interposition of a jejunal J pouch with preservation of hepatic vagus branch and lower esophageal sphincter for T2 gastric cancer without lymph node metastasisRyouichi Tomita
Department of Surgery, Nippon Dental University School of Dentistry, Tokyo, Japan
Hepatogastroenterology 51:1233-40. 2004..lymph node metastasis, which mainly locates in the middle third of stomach, we have performed a total gastrectomy preserving both hepatic vagus branches and the lower esophageal sphincter as a function-preserving surgical procedure.
- Esophageal striated muscle contractions in patients with Chagas' disease and idiopathic achalasiaR O Dantas
Departamento de Clinica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
Braz J Med Biol Res 35:677-83. 2002..of the number of intrinsic neurons of the esophageal myenteric plexus, with consequent absent or partial lower esophageal sphincter relaxation and loss of peristalsis in the esophageal body...
- Association between medications that relax the lower esophageal sphincter and risk for esophageal adenocarcinomaJ Lagergren
Karolinska Institutet and Danderyd Hospital, Stockholm, Sweden
Ann Intern Med 133:165-75. 2000..adenocarcinoma coincided with the introduction of medications that promote reflux by relaxing the lower esophageal sphincter (LES), such as nitroglycerin, anticholinergics, beta-adrenergic agonists, aminophyllines, and ..
- Effect of proximal gastric volume on hiatal herniaR C H Scheffer
Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
Neurogastroenterol Motil 22:552-6, e120. 2010Spatial separation of the diaphragm and the lower esophageal sphincter (LES) occurs frequently and intermittently in patients with a sliding hiatus hernia and favors gastro-esophageal reflux...
- Subtypes of muscarinic receptors in vagal inhibitory pathway to the lower esophageal sphincter of the opossumR J Gilbert
Department of Pharmacology, Medical College of Wisconsin, Milwaukee 53226
Dig Dis Sci 32:1130-5. 1987We assessed the characteristics of muscarinic neural transmission in the vagal inhibitory pathway to the lower esophageal sphincter (LES) of anesthetized opossums. LES relaxation was induced by electrical stimulation of the cervical vagus...
- Return of esophageal function after treatment for achalasia as determined by impedance-manometryRoger P Tatum
Department of Surgery, University of Washington, VA Puget Sound HCS, 1660 S Columbian Way, s 112 gs, Seattle, WA 98108, USA
J Gastrointest Surg 11:1403-9. 2007Treatment for achalasia is aimed at the lower esophageal sphincter (LES), although little is known about the effect, if any, of these treatments on esophageal body function (peristalsis and clearance)...
- Intravenous anesthetics inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation via nitric oxide-cyclic guanosine monophosphate pathway modulation in rabbitsA Kohjitani
Department of Dental Anesthesiology, Okayama University School of Dentistry, Japan
Anesthesiology 95:176-83. 2001Nonadrenergic noncholinergic (NANC) nerves have important roles in the regulation of the lower esophageal sphincter (LES) motility and function. The effects of thiopental, ketamine, and midazolam on NANC LES relaxation were investigated.
- Peppermint oil improves the manometric findings in diffuse esophageal spasmM Pimentel
GI Motility Program, Department of Medicine, Cedars Sinai Medical Center, CSMC Burns and Allen Research Institute, 8700 Beverly Boulevard, Los Angeles, CA 90048, U S A
J Clin Gastroenterol 33:27-31. 2001..Current medical treatment of DES is frequently unsatisfactory. We hypothesized that, as a smooth muscle relaxant, peppermint oil may improve the manometric findings in DES...
- Defining GERDS J Sontag
VA Hospital, Hines, Illinois, USA
Yale J Biol Med 72:69-80. 1999..Hypothesis 1: congenital. The antireflux barrier, comprising the smooth-muscled lower esophageal sphincter, the skeletal-muscled right crural diaphragm and the phreno-esophageal ligament does not completely ..
- Pharyngeal dilation in cricopharyngeus muscle dysfunction and Zenker diverticulumPeter C Belafsky
Center for Voice and Swallowing, University of California, Davis School of Medicine, Department of Otolaryngology HNS, Sacramento, California, USA
Laryngoscope 120:889-94. 2010Prolonged obstruction at the level of the lower esophageal sphincter is associated with a dilated, poorly contractile esophagus...
- Calcium carbonate antacids alter esophageal motility in heartburn sufferersSheila Rodriguez-Stanley
Oklahoma Foundation for Digestive Research, Oklahoma City, Oklahoma 73104, USA
Dig Dis Sci 49:1862-7. 2004..Subjects with hypertensive esophageal contractions or hypertensive lower esophageal sphincter pressure (LESP) were excluded. Subjects with normal to low LESP were included...
- Mechanosensory Motor Neurons of Lower Esophageal SphincterRavinder K Mittal; Fiscal Year: 2013DESCRIPTION (provided by applicant): Introduction: Impaired lower esophageal sphincter (LES) relaxation is the hallmark of achalasia and other spastic motor disorders of the esophagus...
- Obstruction-initiated mechanotranscription in colonic smooth muscle cellsXuan Zheng Shi; Fiscal Year: 2012..stretch-related motility disorders such as achalasia and gastroparesis, where lack of relaxation of lower esophageal sphincter and pylorus sphincter is associated with distension and hypomotility in the esophageal body and antrum, ..
- Simple &Safe Implantable Device for Treatment of Gastroesophageal Reflux DiseaseCLAUDE NMN TIHON; Fiscal Year: 2013..They aim to achieve the same objective as surgery in increasing the constraints of the lower esophageal sphincter (LES)...
- THE DIAPHRAGM--AN EXTERNAL LOWER ESOPHAGEAL SPHINCTERRAVINDER MITTAL; Fiscal Year: 1993..suggested that this pressure resulted exclusively from the tonic activity of the smooth muscles of the lower esophageal sphincter (LES)...
- NEUROPEPTIDE CONTROL OF ENTERIC SPHINCTERSJames Reynolds; Fiscal Year: 1990..Our work determining neuropeptide sequences in the activation of the lower esophageal sphincter responses to acid and the pyloric responses to intraluminal nutrients suggests that Sphincteric reflexes ..
- ESOPHAGEAL RECEPTOR REFLEXES: BRAINSTEM CIRCUITRYSTEVEN ALTSCHULER; Fiscal Year: 1991..Studies indicate that the crural diaphragm and the intrinsic lower esophageal sphincter are important to the genesis of the high pressure zone, and that both muscles act in concert to form the ..
- EVALUATION OF RISK FACTORS FOR BARRETT'S ESOPHAGUSDouglas Corley; Fiscal Year: 2001..People with Barrett's metaplasia have different intakes of fats and medications that relax the lower esophageal sphincter (e.g. calcium channel blockers, beta-agonists, anticholinergic agents) than do controls. B...
- PHYSIOLOGY & PATHOPHYSIOLOGY OF ESOPHAGEAL MOTILITYRaj Goyal; Fiscal Year: 1993..of this research proposal are: (1) to elucidate the physiology of (a) esophageal peristalsis and (b) lower esophageal sphincter (LES) tone and relaxation; (2) to identify the nature of the neurotransmitters involved in esophageal ..
- DEVELOPMENTAL ASPECTS OF UPPER GASTROINTESTINAL MOTILITYA Hillemeier; Fiscal Year: 1990..studies to evaluate the effect of age on: a) Maintenance and modulation of upper esophageal sphincter, lower esophageal sphincter tone and relaxation, and esophageal peristalsis...
- NOVEL ESOPHAGEAL MOTOR FUNCTION ASSESSMENT SYSTEMJianFeng Chen; Fiscal Year: 2006..of such an assessment system with the following specific aims: Aim 1: Automated localization of the lower esophageal sphincter and interactive data acquisition; Aim 2: The removal of respiratory artifacts in the LES pressure ..
- Redefinition of Gastroesophageal Reflux in ChildrenHayat Mousa; Fiscal Year: 2004The prolonged measurement of the pH values close to the lower esophageal sphincter (LES) is considered the "gold standard" in the diagnosis of gastroesophageal reflux (GER). A pH below 4.0 is considered indicative of GER...
- LASER CATHETER FOR TREATMENT OF GASTROESOPHAGEAL REFLUXAshok Gowda; Fiscal Year: 2001..Gastroesophageal reflux disease (GERD) is a physical condition resulting from an inability of the lower esophageal sphincter (LES) to prevent reflux of stomach acids into the esophagus...
- Anatomic and Mechanical Variables of the EGJ in GERDJohn Pandolfino; Fiscal Year: 2006..To date, much of the research on the competence of the EGJ in GERD has been focused on the lower esophageal sphincter. Our hypothesis is that acquired anatomic changes inclusive of, but not restricted to hiatal hernia may ..
- PHARYNGEAL RECEPTORS AND REFLUX DISEASERAVINDER MITTAL; Fiscal Year: 2001..DESCRIPTION: Traditional view holds that gastroesophageal reflux is the consequence of a persistently weak lower esophageal sphincter. Several investigators over the last decade have found that most reflux events, during brief ..
- ROLE OF PUBORECTALIS MUSCLE IN FECAL CONTINENCERAVINDER MITTAL; Fiscal Year: 2007..unreadable] [unreadable]..
- AUTONOMIC CONTROL OF BODY WEIGHT AND FEEDINGTERRY POWLEY; Fiscal Year: 2006..abstract_text> ..
- PURDUE INTEGRATIVE NEUROSCIENCE PROGRAMTERRY POWLEY; Fiscal Year: 2002..Students trained in the interdisciplinary Purdue Integrative Neuroscience program will make substantial contributions to mental health research and its applications in the next century. ..
- Surveillance for Hepatocellular Carcinoma among HCV-infected VeteransHashem El Serag; Fiscal Year: 2009..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
- PHYSIOLOGY AND PATHOPHYSIOLOGY OF ESOPHAGEAL MOTILITYRaj Goyal; Fiscal Year: 2002..The effects of NO on single cells will be relate to nitrergic neurotransmission and physiology with microelectrode, mechanical studies and measurement of esophageal motility in vivo. ..
- Research Symposium on Functional Abdoninal Pain in ChildrenSamuel Nurko; Fiscal Year: 2007..7. To educate the NASPGHAN membership on the state of the art of functional abdominal pain and IBS in children. [unreadable] [unreadable] [unreadable]..
- PLACEBO CONTROLLED STUDY OF BACLOFEN FOR GERD IN CHILDREN WITH CEREBRAL PALSYSamuel Nurko; Fiscal Year: 2008..a high failure rate in children with CP, presumably because they do not affect the rate of transient lower esophageal sphincter relaxations (TLESRs) and do not control or may increase the presence of non-acid reflux...
- THE HIGH PRESSURE ZONE OF THE DISTAL ESOPHAGUSLarry Miller; Fiscal Year: 2006..Abstract): The PI's hypothesis is that the crural diaphragm interacts with the intrinsic lower esophageal sphincter in a very complex manner...
- New Approach to Detect CP and Brain Injury by Term AgeRONALD ARIAGNO; Fiscal Year: 2003..It is essential to discover a new approach to identify brain injury early, before it will be possible to effectively investigate interventions that can improve neurological outcome of these high risk very premature infants. ..
- Novel direct vago-vagal recording of i.v. ghrelin actionDavid Adelson; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Gene Expression in Barrett's EsophagusHashem El Serag; Fiscal Year: 2006..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
- BIOPHYSICAL PRINCIPLES OF PERISTALTIC PHENOMENAPiero Biancani; Fiscal Year: 2006DESCRIPTION (provided by applicant): Disorders of esophageal motor function and Lower Esophageal Sphincter (LES) competence affect more than one in ten adults over 40 and one in four adults over 60 years of age...
- Comparison of Two Therapies for UES DysphagiaReza Shaker; Fiscal Year: 2004..anteroposterior and lateral diameter of maximum deglutitive UES opening, and b. maximum deglutitive laryngeal anterior and superior excursions. ..
- Reflux Disease in Patients with Throat Signs/SymptomsMichael Vaezi; Fiscal Year: 2005..These methods will be employed pre- and post-therapy on all patients to assess their potential clinical utility, especially in those unresponsive to medical therapy after aggressive acid suppression. ..
- MII to characterize reflux in Barrett's esophagusDonald Castell; Fiscal Year: 2005....
- Quantitative Approach to Analysis of Cortical DynamicsHualou Liang; Fiscal Year: 2005..abstract_text> ..