smooth muscle

Summary

Summary: Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)

Top Publications

  1. ncbi Mast-cell infiltration of airway smooth muscle in asthma
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    N Engl J Med 346:1699-705. 2002
  2. ncbi Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase
    Andrew P Somlyo
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia, PO Box 800736, Charlottesville, VA 22908 0736
    Physiol Rev 83:1325-58. 2003
  3. pmc Urinary bladder smooth muscle engineered from adipose stem cells and a three dimensional synthetic composite
    Gregory S Jack
    Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, United States
    Biomaterials 30:3259-70. 2009
  4. ncbi Differences in airway remodeling between subjects with severe and moderate asthma
    Carmela Pepe
    Meakins Christie Laboratories, Montreal H2X2P2, Québec CA
    J Allergy Clin Immunol 116:544-9. 2005
  5. ncbi Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway
    Hiroshi Doi
    Department of Medicine and Biological Science, Education and Research Center, Laboratory Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, Japan
    J Biol Chem 281:28555-64. 2006
  6. pmc Myocardin is a master regulator of smooth muscle gene expression
    Zhigao Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 100:7129-34. 2003
  7. pmc Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cells
    Fernando S Mesquita
    Department of Animal Sciences, University of Illinois, Urbana, Illinois, USA
    Biol Reprod 82:341-51. 2010
  8. pmc Alpha-smooth muscle actin expression upregulates fibroblast contractile activity
    B Hinz
    Department of Pathology, CMU, University of Geneva, 1211 Geneva 4, Switzerland
    Mol Biol Cell 12:2730-41. 2001
  9. pmc Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
    A P Somlyo
    Departments of Molecular Physiology and Biological Physics, Medicine Cardiology and Pathology, University of Virginia Health System, PO Box 800736, Charlottesville, VA 22908 0736, USA
    J Physiol 522:177-85. 2000
  10. ncbi Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression
    Zhigao Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Nature 428:185-9. 2004

Detail Information

Publications398 found, 100 shown here

  1. ncbi Mast-cell infiltration of airway smooth muscle in asthma
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    N Engl J Med 346:1699-705. 2002
    ..We tested the hypothesis that there were differences between the two conditions in the microlocalization of mast cells within the airway smooth muscle.
  2. ncbi Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase
    Andrew P Somlyo
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia, PO Box 800736, Charlottesville, VA 22908 0736
    Physiol Rev 83:1325-58. 2003
    Ca2+ sensitivity of smooth muscle and nonmuscle myosin II reflects the ratio of activities of myosin light-chain kinase (MLCK) to myosin light-chain phosphatase (MLCP) and is a major, regulated determinant of numerous cellular processes...
  3. pmc Urinary bladder smooth muscle engineered from adipose stem cells and a three dimensional synthetic composite
    Gregory S Jack
    Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, United States
    Biomaterials 30:3259-70. 2009
    Human adipose stem cells were cultured in smooth muscle inductive media and seeded into synthetic bladder composites to tissue engineer bladder smooth muscle...
  4. ncbi Differences in airway remodeling between subjects with severe and moderate asthma
    Carmela Pepe
    Meakins Christie Laboratories, Montreal H2X2P2, Québec CA
    J Allergy Clin Immunol 116:544-9. 2005
    ..Several studies have suggested an association between these changes and disease severity. The relationship between the extent of remodeling and lung function is not well defined...
  5. ncbi Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway
    Hiroshi Doi
    Department of Medicine and Biological Science, Education and Research Center, Laboratory Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, Japan
    J Biol Chem 281:28555-64. 2006
    ..cellular fates by interaction between cellular neighbors; however, the molecular mechanism underlying smooth muscle cell (SMC) differentiation by Notch signaling has not been well characterized...
  6. pmc Myocardin is a master regulator of smooth muscle gene expression
    Zhigao Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 100:7129-34. 2003
    Virtually all smooth muscle genes analyzed to date contain two or more essential binding sites for serum response factor (SRF) in their control regions...
  7. pmc Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cells
    Fernando S Mesquita
    Department of Animal Sciences, University of Illinois, Urbana, Illinois, USA
    Biol Reprod 82:341-51. 2010
    ..uterine tumors characterized by extracellular matrix remodeling, increased collagen deposition, and increased smooth muscle cell (SMC) proliferation...
  8. pmc Alpha-smooth muscle actin expression upregulates fibroblast contractile activity
    B Hinz
    Department of Pathology, CMU, University of Geneva, 1211 Geneva 4, Switzerland
    Mol Biol Cell 12:2730-41. 2001
    To evaluate whether alpha-smooth muscle actin (alpha-SMA) plays a role in fibroblast contractility, we first compared the contractile activity of rat subcutaneous fibroblasts (SCFs), expressing low levels of alpha-SMA, with that of lung ..
  9. pmc Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
    A P Somlyo
    Departments of Molecular Physiology and Biological Physics, Medicine Cardiology and Pathology, University of Virginia Health System, PO Box 800736, Charlottesville, VA 22908 0736, USA
    J Physiol 522:177-85. 2000
    We here review mechanisms that can regulate the activity of myosin II, in smooth muscle and non-muscle cells, by modulating the Ca2+ sensitivity of myosin regulatory light chain (RLC) phosphorylation...
  10. ncbi Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression
    Zhigao Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Nature 428:185-9. 2004
    b>Smooth muscle cells switch between differentiated and proliferative phenotypes in response to extracellular cues, but the transcriptional mechanisms that confer such phenotypic plasticity remain unclear...
  11. ncbi Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma?
    Luke J Janssen
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    Am J Physiol Lung Cell Mol Physiol 282:L1161-78. 2002
    ..Airway smooth muscle (ASM) also exhibits robust Ca(2+), K(+), and Cl(-) currents, and there are elaborate signaling pathways that ..
  12. ncbi Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma
    Davinder Kaur
    Institute for Lung Health, and Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, United Kingdom
    Am J Respir Crit Care Med 174:1179-88. 2006
    Airway smooth muscle (ASM) hyperplasia is a feature of asthma, and increases with disease severity...
  13. ncbi Myofibroblasts. I. Paracrine cells important in health and disease
    D W Powell
    University of Texas Medical Branch at Galveston, Departments of Internal Medicine, Physiology, and Biophysics and Pathology, Galveston, Texas 77555, USA
    Am J Physiol 277:C1-9. 1999
    ..Because of their ubiquitous presence in all tissues, myofibroblasts play important roles in various organ diseases and perhaps in multisystem diseases as well...
  14. ncbi Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects
    Xuefei Ma
    Departments of Physiology and Surgery, Faculty of Medicine, University of Manitoba, Manitoba, Winnipeg R3E 3J7, Canada
    Am J Physiol Lung Cell Mol Physiol 283:L1181-9. 2002
    Whether contractility of bronchial smooth muscle cells (BSMC) from asthmatic subjects is significantly altered has never been validated. We tested the hypothesis that such BSMC show increased contractility...
  15. pmc Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
    S S An
    Division of Physiology, Dept of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Eur Respir J 29:834-60. 2007
    Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected that dysfunction of ASM contributes to the ..
  16. pmc Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor beta type I receptor
    Micah L Burch
    From the Diabetes and Cell Biology Laboratory, BakerIDI Heart and Diabetes Institute, Melbourne, 3004 Victoria, Australia
    J Biol Chem 285:26798-805. 2010
    ..receptor-coupled agonists such as thrombin, signal changes the structure of proteoglycans produced by vascular smooth muscle cells (VSMCs)...
  17. ncbi Myocardin: a component of a molecular switch for smooth muscle differentiation
    Jiyuan Chen
    Center for Cardiovascular Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Mol Cell Cardiol 34:1345-56. 2002
    A hallmark of smooth muscle cells (SMCs) in culture and the injured vessel wall is their phenotypic modulation from a differentiated state to one of heightened growth, migration, and matrix synthesis...
  18. doi Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor
    Shu Chuan Ho
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    J Immunol 183:411-20. 2009
    ..Little is known about the regulation of NRF and its role in response to stimuli. Airway smooth muscle (ASM) is a rich source of inflammatory mediators that may regulate the development and progression of airway ..
  19. ncbi Airway smooth muscle cell proliferation is increased in asthma
    P R Johnson
    Department of Pharmacology, University of Sydney, Sydney, Australia
    Am J Respir Crit Care Med 164:474-7. 2001
    Increased airway smooth muscle (ASM) within the bronchial wall of asthmatic patients has been well documented and is likely to be the result of increased muscle proliferation...
  20. ncbi Differentially expressed gene networks in cultured smooth muscle cells from normal and neuropathic bladder
    Mikhail G Dozmorov
    Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73034, USA
    J Smooth Muscle Res 43:55-72. 2007
    ..However, we previously demonstrated that cultured bladder smooth muscle cells (SMCs) derived from neuropathic bladder exhibit and maintain altered pathologic phenotypes in culture...
  21. pmc Signaling processes for initiating smooth muscle contraction upon neural stimulation
    Hai Lei Ding
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 284:15541-8. 2009
    ..among biochemical signaling processes involved in Ca2+/calmodulin (CaM)-dependent phosphorylation of smooth muscle myosin regulatory light chain (RLC) by myosin light chain kinase (MLCK) were determined...
  22. ncbi Smooth Muscle alpha-actin is a direct target of Notch/CSL
    Michela Noseda
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, Canada
    Circ Res 98:1468-70. 2006
    ..regulates cell fate decisions that affect proliferation, survival, and differentiation of endothelial and smooth muscle cells...
  23. ncbi Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin
    Naoya Takeda
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Am J Respir Cell Mol Biol 35:722-9. 2006
    Enhanced proliferation of smooth muscle cells contributes to airway remodeling of bronchial asthma...
  24. pmc Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
    Deepak A Deshpande
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Nat Med 16:1299-304. 2010
    ..We found expression of TAS2Rs on human airway smooth muscle (ASM) and considered these to be avoidance receptors for inhalants that, when activated, lead to ASM ..
  25. ncbi The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain
    H C Etchevers
    Institut d Embryologie Cellulaire et Moleculaire du CNRS et du College de France, 94736 Nogent sur Marne Cedex, France
    Development 128:1059-68. 2001
    ..We show that NCC-derived pericytes and smooth muscle cells are distributed in a sharply circumscribed sector of the vasculature of the avian embryo...
  26. ncbi Modulating signaling events in smooth muscle: cleavage of annexin 2 abolishes its binding to lipid rafts
    Eduard B Babiychuk
    Department of Cell Biology, Institute of Anatomy, University of Bern, Switzerland
    FASEB J 16:1177-84. 2002
    ..In the present study, we demonstrate that the association of annexins 1 and 2 with the smooth muscle cell membrane can be terminated by their proteolytic cleavage...
  27. ncbi Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition
    Andras Masszi
    Department of Surgery, The Toronto General Hospital, Toronto, Ontario M5G 1L7, Canada
    Am J Physiol Renal Physiol 284:F911-24. 2003
    New research suggests that, during tubulointerstitial fibrosis, alpha-smooth muscle actin (SMA)-expressing mesenchymal cells might derive from the tubular epithelium via epithelial-mesenchymal transition (EMT)...
  28. pmc The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo
    Boris Hinz
    Department of Pathology, Centre Medical Universitaire, University of Geneva, 1211 Geneva 4, Switzerland
    J Cell Biol 157:657-63. 2002
    ..The marker of fibroblast-myofibroblast modulation is the neo expression of alpha-smooth muscle actin (alpha-SMA), the actin isoform typical of vascular smooth muscle cells that has been suggested to play ..
  29. ncbi Cytoskeletal modulation of sodium current in human jejunal circular smooth muscle cells
    Peter R Strege
    Department of Physiology and Biophysics, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Cell Physiol 284:C60-6. 2003
    A Na(+) current is present in human jejunal circular smooth muscle cells. The aim of the present study was to determine the role of the cytoskeleton in the regulation of the Na(+) current...
  30. ncbi Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
    K Kimura
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630 01, Japan
    Science 273:245-8. 1996
    ..triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells...
  31. pmc Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3β
    Junaith S Mohamed
    Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:29336-47. 2010
    Airway smooth muscle hypertrophy is one of the hallmarks of airway remodeling in severe asthma. Several human diseases have been now associated with dysregulated microRNA (miRNA) expression...
  32. ncbi Oxidized phospholipids in minimally modified low density lipoprotein induce apoptotic signaling via activation of acid sphingomyelinase in arterial smooth muscle cells
    Alexandra Loidl
    Department of Biochemistry, Technische Universitat Graz, Petersgasse 12 2, A 8010 Graz, Austria
    J Biol Chem 278:32921-8. 2003
    ..We found that in arterial smooth muscle cells, PGPC and POVPC activated sphingomyelinases, in particular the acid isoform, which is known to ..
  33. pmc Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor-alpha in human aortic smooth muscle and embryonic kidney cells
    K T Moe
    Research and Development Unit, National Heart Centre, Singapore
    J Cell Mol Med 10:231-9. 2006
    ..subunit of NADPH oxidase is a critical catalytic component for superoxide production in quiescent vascular smooth muscle cells...
  34. pmc Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis
    A H Baker
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Marlborough Road, Bristol BS2 8HW, United Kingdom
    J Clin Invest 101:1478-87. 1998
    ..system to overexpress individual TIMPs from the cytomegalovirus immediate early promoter in rat aortic smooth muscle cells...
  35. ncbi Invited review: regulation of myosin phosphorylation in smooth muscle
    G Pfitzer
    Department of Physiology, University of Cologne, D 50931 Koeln, Germany
    J Appl Physiol (1985) 91:497-503. 2001
    ..which is targeted to myosin by a regulatory subunit (MYPT1), are the predominant mechanisms of regulation of smooth muscle tone. The activities of both enzymes are modulated by several protein kinases...
  36. ncbi Protein kinases: tuners of the BKCa channel in smooth muscle
    R Schubert
    Institute of Physiology, University of Rostock, PSF 100888, D 18055, Rostock, Germany
    Trends Pharmacol Sci 22:505-12. 2001
    Large-conductance, Ca(2+)-activated K(+) (BK(Ca)) channels in smooth muscle cells are unique because they integrate changes in both intracellular Ca(2+) and membrane potential...
  37. doi T Cells localize with proliferating smooth muscle alpha-actin+ cell compartments in asthma
    David Ramos-Barbon
    Meakins Christie Laboratories, McGill University, Montreal, PQ, Canada
    Am J Respir Crit Care Med 182:317-24. 2010
    Airway remodeling in asthma comprises increased airway smooth muscle (ASM), an alteration linked to airway hyperresponsiveness and disease severity...
  38. ncbi Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists
    Alaina J Ammit
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Am J Respir Cell Mol Biol 26:465-74. 2002
    ..of interleukin (IL)-6 and regulated on activation, normal T cells expressed and secreted (RANTES) from airway smooth muscle (ASM) cells, with the induction of each molecule being differentially regulated (IL-6 increased, RANTES ..
  39. pmc A function for filamentous alpha-smooth muscle actin: retardation of motility in fibroblasts
    L Rønnov-Jessen
    Structural Cell Biology Unit, Institute of Medical Anatomy, The Panum Institute, Copenhagen, Denmark
    J Cell Biol 134:67-80. 1996
    ..six mammalian isoforms of which beta- and gamma-nonmuscle actins are present in all cells, whereas alpha-smooth muscle (alpha-sm) actin is normally restricted to cells of the smooth muscle lineages...
  40. ncbi W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity
    J D Huizinga
    Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
    Nature 373:347-9. 1995
    ..The cellular basis for this intrinsic activity is unknown. The smooth muscle cells of the external muscle layers and the innervated cellular network of interstitial cells of Cajal, which ..
  41. pmc The non-excitable smooth muscle: calcium signaling and phenotypic switching during vascular disease
    Suzanne J House
    The Center for Cardiovascular Sciences, Albany Medical College, 47, New Scotland Avenue, MC 8, Albany, NY, 12208, USA
    Pflugers Arch 456:769-85. 2008
    Calcium (Ca(2+)) is a highly versatile second messenger that controls vascular smooth muscle cell (VSMC) contraction, proliferation, and migration...
  42. ncbi Overexpression of heme oxygenase-1 protects smooth muscle cells against oxidative injury and inhibits cell proliferation
    Min Zhang
    Institute of Sports Medicine, The Third Hospital, Peking University, Beijing, China
    Cell Res 12:123-32. 2002
    To investigate whether the expression of exogenous heme oxygenase-1 (HO-1) gene within vascular smooth muscle cells (VSMC) could protect the cells from free radical attack and inhibit cell proliferation, we established an in vitro ..
  43. pmc Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis
    Erqiu Li
    Department of Biology, Reiss Building, Room 406, Georgetown University, Washington, DC 20057, USA
    Infect Immun 75:4514-8. 2007
    ..Infected mice exhibited increased spontaneous and cholecystokinin (CCK)-induced contractions of longitudinal smooth muscle. In contrast, enhanced contractile responses were not observed in response to acetylcholine, 5-..
  44. ncbi Muscarinic acetylcholine receptor subtypes in smooth muscle
    R M Eglen
    Institute of Pharmacology, Syntex Discovery Research, Palo Alto, CA 94304
    Trends Pharmacol Sci 15:114-9. 1994
    Muscarinic acetylcholine M2 and M3 receptor subtypes are coexpressed in many types of smooth muscle including gastrointestinal smooth muscle, urinary bladder and vascular and airway tissue...
  45. ncbi Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11)
    Kok Choi Kong
    Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, North Carolina 27157, USA
    FASEB J 20:1558-60. 2006
    ..GPCR) agonist thrombin potentiated the mitogenic effect of epidermal growth factor (EGF) on human airway smooth muscle (ASM) by promoting sustained late-phase activation of PI3K and p70S6K via a pathway dependent on Gbetagamma ..
  46. pmc Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat
    Monica G Ferrini
    Charles Drew University, Department of Medicine, Los Angeles, CA 90059, USA
    J Sex Med 6:415-28. 2009
    Corporal veno-occlusive dysfunction (CVOD), which usually is associated with a loss of smooth muscle cells (SMC) and an increase in fibrosis within the corpora cavernosa, can be induced by an injury to the cavernosal nerves...
  47. ncbi Effect of 1,25-(OH)2D3 (a vitamin D analogue) on passively sensitized human airway smooth muscle cells
    Yingfang Song
    Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Respirology 12:486-94. 2007
    In asthma, airway smooth muscle cell (ASMC) hyperplasia plays an important role in airway remodelling...
  48. doi Basic fibroblast growth factor causes urinary bladder overactivity through gap junction generation in the smooth muscle
    Masaaki Imamura
    Department of Urology, Graduate School of Medicine, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, 606 8507 Japan
    Am J Physiol Renal Physiol 297:F46-54. 2009
    ..Increased coupling of bladder smooth muscle cells (BSMC) via gap junctions has been hypothesized as a mechanism for myogenic bladder overactivity in BOO, ..
  49. ncbi Intestinal inflammation downregulates smooth muscle CPI-17 through induction of TNF-alpha and causes motility disorders
    Takashi Ohama
    Dept of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The Univ of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G1429-38. 2007
    ..We previously reported that in vitro treatment of intestinal smooth muscle tissue with IL-1beta decreases the expression of CPI-17, an endogenous inhibitory protein of smooth muscle ..
  50. ncbi Role of interstitial cells of Cajal in neural control of gastrointestinal smooth muscles
    S M Ward
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV, USA
    Neurogastroenterol Motil 16:112-7. 2004
    ..neurotransmission in the gut does not occur through loosely defined synaptic structures between nerves and smooth muscle, but rather via synaptic-like contacts that exist between varicose nerve terminals and intramuscular ICC (ICC-..
  51. ncbi Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers
    Claudia Veigel
    Division of Physical Biochemistry, NIMR, The Ridgeway Mill Hill, London NW7 1AA, UK
    Nat Cell Biol 5:980-6. 2003
    ..Here, we describe a new technique based on optical tweezers to rapidly apply force to a single smooth muscle myosin crossbridge...
  52. ncbi Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle
    Susumu Ohya
    Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuhoku, Nagoya 467 8603, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G277-87. 2002
    ..I(Kr) and I(Ks), respectively) in cardiac myocytes, to membrane currents was examined in stomach circular smooth muscle cells (SMCs)...
  53. ncbi Blockade of kit signaling induces transdifferentiation of interstitial cells of cajal to a smooth muscle phenotype
    S Torihashi
    Department of Anatomy, Nagoya University School of Medicine, Tsurumai, Nagoya, Japan
    Gastroenterology 117:140-8. 1999
    ..We studied the fate of functionally developed ICC after blockade of Kit receptors to determine whether ICC undergo cell death or whether the phenotype of the cells is modified. The fate of undeveloped ICC was also investigated...
  54. pmc Airway smooth muscle growth in asthma: proliferation, hypertrophy, and migration
    J Kelley Bentley
    Department of Pediatrics and Communicable Diseases, University of Michigan, Medical Science Research Building II, 1150 W Medical Center Drive, Room 3570B, Ann Arbor, MI 48109 0688, USA
    Proc Am Thorac Soc 5:89-96. 2008
    Increased airway smooth muscle mass is present in fatal and non-fatal asthma. However, little information is available regarding the cellular mechanism (i.e., hyperplasia vs. hypertrophy)...
  55. doi Tissue-specific regulation of microvascular diameter: opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1
    Tamás Kark
    Division of Clinical Physiology, Institute of Cardiology, Medical and Health Science Center, University of Debrecen, 22 Moricz Zs krt, 4032, Debrecen, Hungary
    Mol Pharmacol 73:1405-12. 2008
    ..detected by reverse transcriptase-polymerase chain reaction in the aorta and in cultured rat aortic vascular smooth muscle cells (A7r5)...
  56. ncbi Pharmacology of airway smooth muscle
    P J Barnes
    Department of Thoracic Medicine, Imperial College, National Heart and Lung Institute, London, United Kingdom
    Am J Respir Crit Care Med 158:S123-32. 1998
    Airway smooth muscle contributes to changes in airway caliber not only through the variations in its tone but also through its contribution to thickness of the airway wall...
  57. ncbi Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway
    Kang Yun Lee
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tun Hwa N Rd, Taipei, Taiwan
    Am J Respir Cell Mol Biol 35:407-14. 2006
    ..Airway smooth muscle (ASM), apart from its contractile properties, is critically involved in the pathogenesis of asthma by ..
  58. ncbi Signal transduction through the RhoA/Rho-kinase pathway in smooth muscle
    Andrew P Somlyo
    Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
    J Muscle Res Cell Motil 25:613-5. 2004
  59. ncbi Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia
    Saadia Eddahibi
    INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
    Circulation 113:1857-64. 2006
    The mechanism of pulmonary artery smooth muscle cell (PA-SMC) hyperplasia in idiopathic pulmonary artery hypertension (iPH) may involve both an inherent characteristic of PA-SMCs and abnormal control by external stimuli...
  60. ncbi The regulation of smooth muscle contractility by zipper-interacting protein kinase
    Eikichi Ihara
    Smooth Muscle Research Group and Department of Biochemistry and Molecular Biology, University of Calgary, Faculty of Medicine, 3330 Hospital Drive N W, Calgary, AB T2N 4N1, Canada
    Can J Physiol Pharmacol 85:79-87. 2007
    b>Smooth muscle contractility is mainly regulated by phosphorylation of the 20 kDa myosin light chains (LC20), a process that is controlled by the opposing activities of myosin light chain kinase (MLCK) and myosin light chain phosphatase (..
  61. ncbi BK channel beta1-subunit regulation of calcium handling and constriction in tracheal smooth muscle
    Iurii Semenov
    Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Lung Cell Mol Physiol 291:L802-10. 2006
    ..The BK channel accessory beta1-subunit promotes channel activation in smooth muscle and is required for proper tone in the vasculature and bladder...
  62. doi Effect of peroxisome proliferator-activated receptor-gamma on airway smooth muscle thickening in a murine model of chronic asthma
    Chin Kook Rhee
    Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seocho Gu, Seoul, Korea
    Int Arch Allergy Immunol 148:289-96. 2009
    ..In this study we examined the effect of a PPAR-gamma agonist on the airway smooth muscle and the production of transforming growth factor (TGF)-beta1 and vascular endothelial growth factor (VEGF).
  63. ncbi Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPL
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:32807-14. 2002
    ....
  64. ncbi New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant
    John E Dominy
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    Nutr Rev 62:348-53. 2004
    ..gamma-lyase and cystathionine beta-synthase, in catalyzing the desulfhydration of cysteine in brain and smooth muscle. The H2S produced from cysteine functions as a neuromodulator and smooth muscle relaxant...
  65. ncbi Spasmolytic and tonic effect of Iberogast (STW 5) in intestinal smooth muscle
    H P T Ammon
    Department of Pharmacology, Institute of Pharmaceutical Sciences, University of Tubingen, 72076 Tubingen, Germany
    Phytomedicine 13:67-74. 2006
    ..with acetylcholine or histamine, in order to find a possible effect on the contractility of intestinal smooth muscle. STW 5 decreased acetylcholine- and histamine-induced contraction of guinea pig ileum...
  66. ncbi Structural and functional changes in the airway smooth muscle of asthmatic subjects
    C Y Seow
    Departments of Anatomy, Pharmacology, and Medicine, and St Paul s Hospital Pulmonary Research Laboratory, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 158:S179-86. 1998
    It has been recognized since the early 1920s that the amount of smooth muscle in asthmatic subjects' airways is markedly increased...
  67. pmc SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation
    Xuguang Nie
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Development 137:755-65. 2010
    ..It was expressed in undifferentiated smooth muscle (SM) progenitors, but was downregulated in differentiating SM cells (SMCs) and had disappeared by E18.5...
  68. pmc Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands
    Duncan Sousa
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts, USA
    Biophys J 99:862-8. 2010
    ..In contrast, smooth muscle tropomyosin is more a mixture of varying-length chains of end-to-end polymers...
  69. pmc Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis
    Mei Y Speer
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    J Cell Biochem 110:935-47. 2010
    Vascular calcification is a major risk factor for cardiovascular morbidity and mortality. Smooth muscle cells (SMCs) may play an important role in vascular cartilaginous metaplasia and calcification via reprogramming to the ..
  70. ncbi The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle
    Dale D Tang
    Department of Cellular and Integrative Physiology, School of Medicine, Indiana University, Indianapolis, 46202, USA
    J Biol Chem 280:23380-9. 2005
    Actin polymerization has been shown to occur in tracheal smooth muscle tissues and cells in response to contractile stimulation, and there is evidence that the polymerization of actin is required for contraction...
  71. pmc The contribution of Ca2+ signaling and Ca2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice
    Yan Bai
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Lung Cell Mol Physiol 296:L947-58. 2009
    ..determine the relative contributions of Ca(2+) signaling and Ca(2+) sensitivity to the contractility of airway smooth muscle cells (SMCs), we compared the contractile responses of mouse and rat airways with the lung slice technique...
  72. doi Airway smooth muscle cell tone amplifies contractile function in the presence of chronic cyclic strain
    Nigel J Fairbank
    School of Biomedical Engineering, Dalhousie Univ, 5981 Univ Ave, Halifax, Nova Scotia B3H 1W2, Canada
    Am J Physiol Lung Cell Mol Physiol 295:L479-88. 2008
    ..with continuous stretching due to breathing may be involved in altering the contractile function of airway smooth muscle (ASM)...
  73. ncbi Sildenafil preserves intracorporeal smooth muscle after radical retropubic prostatectomy
    Eric J Schwartz
    Division of Urology, University of Connecticut Health Sciences Center, Farmington, USA
    J Urol 171:771-4. 2004
    ..The loss of intracorporeal smooth muscle (SM) and an increase in intracorporeal fibrosis have been demonstrated in vasculogenic impotence and ..
  74. pmc miR-10a contributes to retinoid acid-induced smooth muscle cell differentiation
    Huarong Huang
    Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:9383-9. 2010
    ..The purpose of this study is to determine the role of miRs during smooth muscle cell (SMC) differentiation from embryonic stem cells (ESCs)...
  75. pmc Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma
    Thomas Trian
    Universite Bordeaux 2, Laboratoire de Physiologie Cellulaire Respiratoire, F 33076 Bordeaux, France
    J Exp Med 204:3173-81. 2007
    ..are characterized by different patterns of airway remodeling, which all include an increased mass of bronchial smooth muscle (BSM). A remaining major question concerns the mechanisms underlying such a remodeling of BSM...
  76. pmc Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages
    Aiping Zhao
    Department of Medicine and the Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 135:217-225.e1. 2008
    ..The present study investigated the role of macrophages and the arginase pathway in nematode-induced changes in intestinal smooth muscle function and worm expulsion.
  77. ncbi Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression
    Biao Hu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Am J Respir Cell Mol Biol 29:397-404. 2003
    Transforming growth factor-beta (TGF-beta)-induced alpha-smooth muscle actin (ASMA) expression is a key indicator of myofibroblast differentiation from fibroblasts...
  78. ncbi Regulation of alpha-smooth muscle actin gene expression in myofibroblast differentiation from rat lung fibroblasts
    S G Roy
    Department of Pathology, University of Michigan Medical School, 48109-0602, Ann Arbor, MI, USA
    Int J Biochem Cell Biol 33:723-34. 2001
    Myofibroblasts express alpha-smooth muscle actin and have a phenotype intermediate between fibroblasts and smooth muscle cells...
  79. ncbi Vascular smooth muscle and endothelial functions in aging
    Oguzhan Yildiz
    Department of Pharmacology, Gulhane Military Medical Academy, Medical School, 06018 Etlik, Ankara, Turkey
    Ann N Y Acad Sci 1100:353-60. 2007
    ..As aging occurs, smooth muscle cells (SMCs) progressively migrate from the tunica media and accumulate into the tunica intima...
  80. pmc Airway hyperresponsiveness, remodeling, and smooth muscle mass: right answer, wrong reason?
    Madavi N Oliver
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Respir Cell Mol Biol 37:264-72. 2007
    We quantified the effects of airway wall remodeling upon airway smooth muscle (ASM) shortening. Isolated ASM from sheep was attached to a servo-controller that applied a physiologic load...
  81. ncbi Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma
    S M Drouin
    University of Texas Houston Institute of Molecular Medicine for the Prevention of Human Diseases, and Department of Biochemistry and Molecular Biology, Houston, TX 77030, USA
    J Immunol 166:2025-32. 2001
    ..peptides, C3a and C5a, in the lung can induce respiratory distress characterized by contraction of the smooth muscle walls in bronchioles and pulmonary arteries and aggregation of platelets and leukocytes in pulmonary vessels...
  82. pmc Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction
    Susan J Gunst
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Cell Physiol 295:C576-87. 2008
    A growing body of data supports a view of the actin cytoskeleton of smooth muscle cells as a dynamic structure that plays an integral role in regulating the development of mechanical tension and the material properties of smooth muscle ..
  83. ncbi Regulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GMP-dependent protein kinase
    Thomas M Lincoln
    Department of Physiology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Front Biosci 11:356-67. 2006
    ..science review examines the role of cGMP and cGMP-dependent protein kinase (PKG) in the regulation of vascular smooth muscle cell (VSMC) phenotype...
  84. ncbi Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src
    Daniel N Streblow
    Department of Molecular Microbiology and Immunology and The Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Portland Oregon 97201, USA
    J Biol Chem 278:50456-65. 2003
    The human cytomegalovirus-encoded chemokine receptor US28 induces arterial smooth muscle cell (SMC) migration; however, the underlying mechanisms involved in this process are unclear...
  85. pmc Acetylcholine-induced calcium signaling and contraction of airway smooth muscle cells in lung slices
    Albrecht Bergner
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 119:187-98. 2002
    The Ca(2+) signaling and contractility of airway smooth muscle cells (SMCs) were investigated with confocal microscopy in murine lung slices (approximately 75-microm thick) that maintained the in situ organization of the airways and the ..
  86. pmc Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions
    James West
    Vanderbilt University, 1161 21st Avenue S, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 295:L744-55. 2008
    ..To determine the in vivo consequences of BMPR2 tail domain mutation, we created a smooth muscle-specific doxycycline-inducible BMPR2 mutation with an arginine to termination mutation at amino acid 899...
  87. ncbi Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells
    Rowland W Rees
    Wolfson Institute for Biomedical Research, University College London, United Kingdom
    J Urol 170:2517-22. 2003
    ..urinary flow obstruction by 2 components, namely an enlarged prostate (static component) and elevated smooth muscle tone (dynamic component)...
  88. ncbi Gastrointestinal peristalsis: joint action of enteric nerves, smooth muscle, and interstitial cells of Cajal
    J D Huizinga
    Intestinal Disease Research Programme and Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada
    Microsc Res Tech 47:239-47. 1999
    ..now been isolated and their intrinsic properties reveal the presence of rhythmic inward currents not found in smooth muscle cells...
  89. ncbi epsilon-sarcoglycan replaces alpha-sarcoglycan in smooth muscle to form a unique dystrophin-glycoprotein complex
    V Straub
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 274:27989-96. 1999
    ..Here, we have characterized the smooth muscle sarcoglycan complex...
  90. ncbi Structural changes in the airways in asthma: observations and consequences
    Tony R Bai
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Clin Sci (Lond) 108:463-77. 2005
    ..submucosal mucus glands, angiogenesis, increased matrix deposition in the airway wall, increased airway smooth muscle mass, wall thickening and abnormalities in elastin...
  91. ncbi Transforming growth factor-beta1-induced expression of smooth muscle marker genes involves activation of PKN and p38 MAPK
    Rebecca A Deaton
    Cardiovascular Research Institute, Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    J Biol Chem 280:31172-81. 2005
    Differentiated vascular smooth muscle cells (SMCs) exhibit a work phenotype characterized by expression of several well documented contractile apparatus-associated proteins...
  92. ncbi Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons
    S M Ward
    Department of Physiology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    J Neurosci 20:1393-403. 2000
    Interstitial cells of Cajal (ICC) are interposed between enteric neurons and smooth muscle cells in gastrointestinal muscles...
  93. ncbi The differentiation and function of myofibroblasts is regulated by mast cell mediators
    J Gailit
    Department of Veterans Affairs Medical Center, Northport, New York, USA
    J Invest Dermatol 117:1113-9. 2001
    Myofibroblasts are fibroblasts that express certain features of smooth muscle differentiation...
  94. ncbi Store-operated Ca2+ entry in porcine airway smooth muscle
    Binnaz Ay
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Physiol Lung Cell Mol Physiol 286:L909-17. 2004
    ..via store-operated Ca(2+) channels (SOCC)] was characterized in enzymatically dissociated porcine airway smooth muscle (ASM) cells...
  95. ncbi Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis
    J M Miano
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Circ Res 75:803-12. 1994
    We cloned a portion of the mouse smooth muscle myosin heavy chain (SM-MHC) cDNA and analyzed its mRNA expression in adult tissues, several cell lines, and developing mouse embryos to determine the suitability of the SM-MHC promoter as a ..
  96. ncbi Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway
    Deepak A Deshpande
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, MN, USA
    Am J Respir Cell Mol Biol 31:36-42. 2004
    ..role in the regulation of intracellular calcium responses to agonists in a variety of cells, including airway smooth muscle (ASM) cells...
  97. pmc TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle
    Nezahat Tugba Durlu-Kandilci
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
    J Biol Chem 285:24925-32. 2010
    Agonists such as those acting at muscarinic receptors are thought to induce contraction of smooth muscle primarily through inositol 1,4,5-trisphosphate production and release of Ca(2+) from sarcoplasmic reticulum...
  98. pmc Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6
    Fay Hollins
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, United Kingdom
    J Immunol 181:2772-80. 2008
    ..This is particularly evident in asthma where they localize to the airway smooth muscle (ASM) bundles...
  99. pmc Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors
    Richard Einstein
    ExonHit Therapeutics, Inc, 217 Perry Parkway, Building 5, Gaithersburg, MD 20877, USA
    Proc Natl Acad Sci U S A 105:5230-5. 2008
    ..In many tissues, such as airway smooth muscle (ASM), complex, unexpected, or paradoxical responses to agonists/antagonists occur without known mechanisms...
  100. ncbi Dedicated myosin light chain kinases with diverse cellular functions
    K E Kamm
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9040, USA
    J Biol Chem 276:4527-30. 2001
  101. doi Electrospun collagen-chitosan nanofiber: a biomimetic extracellular matrix for endothelial cell and smooth muscle cell
    Z G Chen
    State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China
    Acta Biomater 6:372-82. 2010
    ..The results show that both endothelial cells and smooth muscle cells proliferate well on or within the nanofiber...

Research Grants71

  1. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..interstitial MMPs (13-18) and directly degrades cell surface proteins such as fibronectin (19), resulting in smooth muscle cell (20,21) and cardiomyocyte (22) death...
  2. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..before measuring metabolic and functional responses to insulin in primary cultured rat endothelial, vascular smooth muscle and cardiomyocyte cells...
  3. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..increased production of collagen and other extracellular matrix (ECM) components, and accumulation of alpha smooth muscle actin (ASMA) positive myofibroblasts...
  4. ROLE OF Rac AND REACTIVE OXYGEN SPECIES IN KAPOSI'S SARCOMA VIRAL ONCOGENESIS
    Enrique A Mesri; Fiscal Year: 2013
    ..We have found that expression of a constitutively-active Rac1 mutant (RacCA) driven by -smooth muscle actin (-SMA) promoter in transgenic mice led to the formation of lesions that strongly resemble those of ..
  5. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..between ANG II and S6K1 activation and INS signaling in primary cultured endothelial cells, vascular smooth muscle cells and cardiomyocytes...
  6. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..skin, liver, lymphocytes), adipose tissue dynamics and fat distribution, insulin sensitivity, and vascular smooth muscle cell proliferation...
  7. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    ..as well as enzyme activity are decreased in IPAH and test the impact of EC-SOD expression on pulmonary artery smooth muscle cell proliferation...
  8. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..Ischemia is one of the leading causes of smooth muscle spasm in the stomach, intestine, uterus, and bronchioles...
  9. Monitoring cellular redox signaling and oxidant stress in vivo
    Paul T Schumacker; Fiscal Year: 2010
    ..In Aim 3 we will breed the RoGFP mice with smooth muscle-specific Cre recombinase mice, to elicit RoGFP expression in pulmonary artery smooth muscle cells in the lung...
  10. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..identified and have begun to characterize a new heme-containing peroxidase that is present in heart, vascular smooth muscle and endothelial cells...
  11. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..50% of fistulas fail soon after their surgical construction due, in part, to intimal hyperplasia of venous smooth muscle cells (SMC) that occludes the fistula lumen...
  12. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..gt;30% increase in alveolar density, and >30% reductions in pulmonary fibrosis, pulmonary arteriolar smooth muscle hypertrophy, right ventricular mass, PMN infiltration, lipid peroxidation, peroxynitrite and poly(ADP-ribose) ..
  13. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..NTs and their receptors have now been found in different lung components including airway smooth muscle (ASM), with altered expression observed in asthma, allergy, and even lung cancer...
  14. The Role of Vascular MR-Regulated Genes in Vascular Function and Disease
    Iris Z Jaffe; Fiscal Year: 2013
    ..We recently discovered that MR is expressed and regulates gene transcription programs in human vascular smooth muscle cells (VSMC) and endothelial cells...
  15. Mechanisms and Consequences of Reduced PPAR gamma in Pulmonary Hypertension
    C Michael Hart; Fiscal Year: 2013
    ..Complementary studies will be performed in vitro in human pulmonary artery endothelial or smooth muscle cells (HPAEC or HPASMC) exposed to hypoxia or in HPAEC or HPASMC isolated from control or PH patients...
  16. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..and adventitia contribute critically to the pathogenesis of PAH, excessive proliferation of pulmonary arterial smooth muscle cells (PASMC) is a major contributor to the obstructive vascular pathology...
  17. Platelet TSP1 Mediates Vascular Disease and pulmonary hypertension in Sickle Cell
    Enrico M Novelli; Fiscal Year: 2013
    ..but also increases reactive oxygen species (ROS) production and endothelin A (ETA) receptor expression in smooth muscle, both canonical vasoconstrictive and mitogenic pathological signaling pathways contributing to pulmonary ..
  18. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..Demonstration that R-100 increases alveolar density and reduces pulmonary fibrosis, pulmonary arteriolar smooth muscle hypertrophy, and right ventricular mass will justify progression to a confirmatory study in premature lambs...
  19. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..studies, we will employ unique, genetically modified mice that permit us to increase or decrease vascular smooth muscle levels of reactive oxygen species to study how these contribute to arterial stiffening, vascular collagen and ..
  20. Interactions of the RAAS and a Western Diet on Insulin Metabolic Actions
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..Ang II/aldosterone/WD and S6K1 activation and INS signaling in primary cultured endothelial cells, vascular smooth muscle cells and cardiomyocytes...
  21. Dynamics of Kinesins, Dyneins, and Myosins
    Paul R Selvin; Fiscal Year: 2010
    ..We wish to study: a) Smooth muscle myosin: To continue the study of the conformational changes within the actomyosin complex using lanthanide-..
  22. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..1- and 21-subunits are altered and functional expression of BKCa current diminished in coronary microvascular smooth muscle cells from Ossabaw swine with the metabolic syndrome...
  23. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..In pulmonary arterial smooth muscle cells (PASMCs), Ca2+ signals that originate from ryanodine receptors (RyRs) play major roles in agonist- and ..
  24. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2013
    ..Upon BMP4 stimulation, FHL2 translocates to the nucleus and inhibits BMP-mediated activation of vascular smooth muscle cell (VSMC)- specific contractile genes in pulmonary artery smooth muscle cells (PASMCs)...
  25. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
    ..mass spectrometry) will be evaluated by molecular targeting of the kinase or phosphorylation sites in cultured smooth muscle cells and by knocking in dysregulated KCNQ channels in transgenic mice...
  26. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2013
    ..The faculty here at the University of Nevada School of Medicine is widely recognized for their expertise in smooth muscle physiology...
  27. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2012
    ..The faculty here at the University of Nevada School of Medicine is widely recognized for their expertise in smooth muscle physiology...
  28. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..the tubular scaffold and the two main cell types of blood vessels (endothelial cells lining the lumen, and smooth muscle cells in the wall)...
  29. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..segments, full-thickness muscle strips, variously dissected muscle strips), and culture (pure neuronal, pure smooth muscle, and nerve/muscle co-cultures) preparations...
  30. Neuropilin and semaphorin, anti-angiogenesis activities and mechanisms
    Michael Klagsbrun; Fiscal Year: 2009
    ..NRP2 Lacz+/- mice show strong expression of NRP2 in bladder smooth muscle cells (BSMC). SEMA3F alters the morphology of these SMC, a new SEMA3F function...
  31. The unique role of B-Raf in murine cardiac development and postnatal function
    Natasha N Chattergoon; Fiscal Year: 2013
    ..I studied vascular smooth muscle growth in the context of primary pulmonary hypertension for my doctoral dissertation...
  32. Myosin phosphatase autoinhibition in gastrointestinal smooth muscle contraction
    Avril V Somlyo; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Alterations in the contractile state of smooth muscle (SM) plays a key role in gastrointestinal diseases such as gastric, intestinal and sphincter dysfunction, abnormal motility and other pathologies...
  33. Mechanisms of Airway Smooth Muscle Hypertrophy
    Marc B Hershenson; Fiscal Year: 2013
    ..In the "new BPD," alveolar septa are thickened with collagen and 1-smooth muscle actin-positive, transforming growth factor (TGF)-[unreadable]-positive myofibroblasts...
  34. Ionic currents in gastrointestinal smooth muscle
    Hamid I Akbarali; Fiscal Year: 2013
    ..is that inflammation induces specific changes in expression, regulation and kinetics of ion channels in smooth muscle cells...
  35. Aldosterone, Autophagy, and Arterial Stiffness
    Jane A Leopold; Fiscal Year: 2013
    ..arterial stiffness is associated with architectural remodeling of the vessel media characterized by vascular smooth muscle cell disarray, increased deposition of aberrant collagen and fragmentation of elastin, all of which contribute ..
  36. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    ..Novel hypothesis suggests the effective utilization of knowledge about smooth muscle cells, organs, sphincters and possible replacement of defective IAS sphincters with implantation of ..
  37. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..Asthma is an inflammatory disease characterized by hypertrophy of smooth muscle, airway obstruction, and increased mucous production3...
  38. Irritable bowel syndrome-diarrhea: the role of gluten intolerance and HLA-DQ2
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..results in CD3, CD4 lymphocyte and macrophage infiltration of villi, and increased contractile responses of smooth muscle to electrical field stimulation and carbachol (Verdu et al 2008)...
  39. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..through cell surface receptors, recently it has been proposed to act as an intracellular signaling molecule in smooth muscle, platelets, and pancreatic beta-cells...
  40. Endothelium-Myocardium Interaction in Netrin-1 Induced Cardioprotection
    HUA LINDA CAI; Fiscal Year: 2013
    ..This shares some similarity with endothelium regulation of vascular smooth muscle relaxation and signaling in conduit arteries...
  41. TNF Family Members and Control of Fibrotic Disease
    Michael Croft; Fiscal Year: 2013
    ..T cells, dendritic cells, and inflamed epithelial cells, was responsible for mediating collagen production, smooth muscle hyperplasia, and overall fibrotic symptoms...
  42. Research Training in Cardiovascular and Pulmonary Diseases
    S Jamal Mustafa; Fiscal Year: 2012
    ..physiology, cardiac pathobiology, airway and vascular reactivity, lung epithelial pathology, vascular smooth muscle biology, gene expression and lipids, ischemia-reperfusion, reactive oxygen radicals, cell signaling pathways, ..
  43. Biochemical, Biomechanical & Morphological Properties of Quantitative Ultrasound
    Barbara L McFarlin; Fiscal Year: 2010
    ..Pharmacologic agents to arrest preterm labor have functions to modify contracting smooth muscle not cervical ripening,5 and have failed to reduce preterm birth rates in the last 40 years...
  44. Mechanisms for cell specific modulation of proliferation and migration
    Thomas S Monahan; Fiscal Year: 2013
    ..Intimal hyperplasia or restenosis results from the pathologic proliferation and migration of smooth muscle cells at the site of vascular injury, caused by surgery or angioplasty...
  45. ANP Receptor: Molecular approach of signaling mechanisms
    Kailash N Pandey; Fiscal Year: 2013
    ..mutagenesis and determine the role of ANP/NPRA signaling and physiological function(s) in vascular smooth muscle and mesangial cells transfected with wild-type and carboxyl-terminal mutant receptors in vitro and transgenic ..
  46. TRP channels in regulation of vascular tone
    David X Zhang; Fiscal Year: 2013
    ..Flow stimulates vascular endothelial cell to release vasodilator factors that subsequently relax underlying smooth muscle, a response often known as flow-mediated dilation (FMD)...
  47. Vascular Surgery - Estrogen and the Injury Response
    Richard H Karas; Fiscal Year: 2012
    ..of this application that vascular endothelial cell ER1 regulates eNOS expression and activity;vascular smooth muscle cell (VSMC) ER1 mediates estrogen inhibition of VSMC proliferation during vascular injury and atherosclerosis;..
  48. ECM compliance and cell cycle control
    RICHARD ASSOIAN; Fiscal Year: 2012
    ..by which ECM compliance and FAK regulate cyclin D1 gene expression in MEFs and freshly isolated mouse vascular smooth muscle cells (VSMCs)...
  49. Interventions Against the Molecular Etiology of BMPR2-induced PAH
    James D West; Fiscal Year: 2013
    ..Also, all BMPR2 mutations tested in cultured smooth muscle cells lead to a ~2x increase in peroxide formation, and RNA expression changes suggestive of increased ROS and ..
  50. Cellular interactions in asthma
    CHRISTOPHER DAVID CABALLERO ALLEN; Fiscal Year: 2012
    ..be the interaction of inflammatory cells with stromal components of the lung, including epithelial cells and smooth muscle cells...
  51. TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNG
    Namasivayam Ambalavanan; Fiscal Year: 2012
    ..Our laboratory has made the novel observations that Thy-1 null mice have IAD and increased phospho-Smad2, (-smooth muscle actin, interstitial collagen, tissue lung resistance (but normal airway resistance), and decreased lung ..
  52. Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
    Min Li; Fiscal Year: 2012
    ..processes including cardiac and neuronal excitation, sensory transduction, trans-epithelial secretion, smooth muscle contraction, and fertilization. In collaboration with Dr...
  53. Role of Inflammation in the Pathobiology of Abdominal Aortic Aneurysm
    KATHLEEN RAMAN; Fiscal Year: 2013
    ..inflammation results in two fundamental structural changes which underlie AAA;elastin degradation and loss of smooth muscle cells (SMC) within the aortic media...
  54. Neprilysin and Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms
    EDWARD CHARLES DEMPSEY; Fiscal Year: 2013
    ..Proliferation of pulmonary artery (PA) smooth muscle cells (SMCs) at the medial/adventitial border and migration to more distal sites are prominent features of the ..
  55. Contribution of Gstm1 to the severity of hypertension and chronic kidney disease
    Thu H Le; Fiscal Year: 2013
    ..for susceptibility to renal vascular injury, and that reduced expression of Gstm1 causes increased vascular smooth muscle cell (VSMC) proliferation, migration and oxidative stress...
  56. STRUCTURE AND FUNCTION OF HEPARIN COFACTOR II
    Douglas M Tollefsen; Fiscal Year: 2010
    ..is an inhibitor of thrombin in plasma that can be activated by dermatan sulfate (DS) proteoglycans on vascular smooth muscle cells and fibroblasts...
  57. Function and regulation of elemental Ca2+ signaling in urethral smooth muscle
    Ronghua Zhuge; Fiscal Year: 2013
    ..provided by applicant): Ca2+ signals and ion channels are essential in controlling the contraction of smooth muscle in several tissue types and organs...
  58. THE ROLE OF A-BETA SPECIES IN VASCULAR SMOOTH MUSCLE CELL AND CEREBRAL ARTERIOLE
    Gregory J Zipfel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The role of A[unreadable] species in vascular smooth muscle cell and cerebral arteriole dysfunction...
  59. Nitrated fatty acids/PPARgamma in the control of renal and vascular functions
    Tianxin Yang; Fiscal Year: 2012
    ..functions of PPAR using mice with conditional deletion of PPAR in endothelial cells (EC PPAR KO) and vascular smooth muscle cells (SM PPAR KO)...
  60. Epigenetic regulation of stem cell senescence in aging
    DAVID TOCHUKWU ASUZU; Fiscal Year: 2011
    ..by a dynamic interaction between the many cell types in the GI tract including epithelial cells, immune cells, smooth muscle cells, neurons and glia, and interstitial cells of Cajal (ICC)...
  61. ClC-3 Chloride Ion Channels in Vascular Smooth Muscle
    Fred Lamb; Fiscal Year: 2009
    ..We have shown that in vascular smooth muscle (VSM) cells, superoxide (O2-") production in response to cytokines (TNF[unreadable] and IL-1[unreadable]) ..
  62. SMOOTH MUSCLE MYOSIN PHOSPHATASE SUBUNIT ISOFORMS
    Steven A Fisher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Myosin phosphatase (MP) is the primary effector of smooth muscle relaxation and a key target of signaling pathways that regulate vessel tone...
  63. ACTIONS OF CYCLIC GMP IN SMOOTH MUSCLE
    Thomas Lincoln; Fiscal Year: 1999
    Cyclic GMP mediates vascular smooth muscle relaxation to nitric oxide and atrial natriuretic peptides...
  64. MODELS OF IN VIVO MYOMETRIAL GENE TRANSFER
    Gregory Christman; Fiscal Year: 2001
    ..Recently, gene transfer has been shown to be effective in vascular smooth muscle using the herpes virus thymidine kinase/ganciclovir (HSV-tk/GCV) cytotoxic gene therapy approach to ablate ..
  65. Mechanisms of Renal Vasodilation by Relaxin
    Kirk P Conrad; Fiscal Year: 2010
    ..Ultimately, vasodilation by relaxin depends on endothelial nitric oxide that relaxes the underlying vascular smooth muscle. The overarching hypothesis of this grant proposal is that the vasodilatory actions of relaxin hinge on bi-..
  66. REGULATION OF CYCLIC GMP DEPENDENT PROTEIN KINASE
    MICHAEL UHLER; Fiscal Year: 1999
    ..to mediate the intracellular effects of nitric oxide and atrial natriuretic factor (ANF) on the relaxation of smooth muscle. This same smooth muscle relaxation is thought to be the mechanism of action of nitrovasodilators in mediating ..
  67. MOLECULAR REGULATION OF SMOOTH MUSCLE ACTOMYOSIN
    Mitsuo Ikebe; Fiscal Year: 2004
    The long term objective of this research is to understand the regulation and function of myosin in smooth muscle cells...
  68. CGMP DEPENDENT PROTEIN KINASE IN VASCULAR BIOLOGY
    HOWARD SURKS; Fiscal Year: 2003
    b>Smooth muscle contractile state determines vascular tone, and ischemic and hypertensive cardiovascular diseases arise in part from abnormalities in smooth muscle cell function...
  69. CONTRACTILE PROTEIN ACCUMULATION IN AIRWAY SMOOTH MUSCLE
    Julian Solway; Fiscal Year: 2002
    One hallmark of asthmatic airway remodeling is an excess accumulation of otherwise normal-appearing smooth muscle. Contraction of this muscle constricts the airway lumen during acute asthma attacks...
  70. SIGNALING BY VASOPRESSIN--ARTERIAL SMOOTH MUSCLE CELLS
    KENNETH BYRON; Fiscal Year: 2002
    ..AVP is both a potent vasoconstrictor and a mitogen for vascular smooth muscle. These effects of AVP are important not only for physiological regulation of blood flow and pressure, but may ..
  71. Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway disea
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
    ..IL-13 can each independently induce airway hyperresponsiveness (AHR) in mice through direct effects on airway smooth muscle cells;2) AHR is induced independently of eosinophilia and goblet cell hyperplasia;3) induction of AHR by IL-4 ..