respiratory muscles

Summary

Summary: These include the muscles of the DIAPHRAGM and the INTERCOSTAL MUSCLES.

Top Publications

  1. ncbi Use of inspiratory strength training to wean six patients who were ventilator-dependent
    Samuel S Sprague
    Phys Ther 83:171-81. 2003
  2. ncbi American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
    Linda Nici
    Am J Respir Crit Care Med 173:1390-413. 2006
  3. pmc Effect of acute hypoxia on respiratory muscle fatigue in healthy humans
    Samuel Verges
    HP2 laboratory INSERM ERI17, Joseph Fourier University, Grenoble University Hospital, Grenoble, France
    Respir Res 11:109. 2010
  4. pmc A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Rd, London SW3 6NP, UK
    Respir Res 8:25. 2007
  5. ncbi The effects of 1 year of specific inspiratory muscle training in patients with COPD
    Marinella Beckerman
    Department of Medicine A, Hillel Yaffe Medical Center, Hadera, Israel
    Chest 128:3177-82. 2005
  6. ncbi Comparative assessment of the quadriceps and the diaphragm in patients with COPD
    Marc André Caron
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada G1V 4G5
    J Appl Physiol (1985) 107:952-61. 2009
  7. ncbi +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Road, London SW3 6NP, United Kingdom
    Am J Clin Nutr 83:912-7. 2006
  8. ncbi Ubiquitination and proteolysis in limb and respiratory muscles of patients with chronic obstructive pulmonary disease
    Richard Debigare
    P T, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725, Chemin Ste Foy, PQ, G1V 4G5 Canada
    Proc Am Thorac Soc 7:84-90. 2010
  9. ncbi Inspiratory muscle training increases inspiratory muscle strength in patients weaning from mechanical ventilation: a systematic review
    Lisa Moodie
    Auckland District Health Board, New Zealand
    J Physiother 57:213-21. 2011
  10. pmc Nutritional status is related to fat-free mass, exercise capacity and inspiratory strength in severe chronic obstructive pulmonary disease patients
    Pollyane Galinari Sabino
    Department of Physical Therapy, Londrina State University, Parana, Brazil
    Clinics (Sao Paulo) 65:599-605. 2010

Detail Information

Publications284 found, 100 shown here

  1. ncbi Use of inspiratory strength training to wean six patients who were ventilator-dependent
    Samuel S Sprague
    Phys Ther 83:171-81. 2003
    ....
  2. ncbi American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
    Linda Nici
    Am J Respir Crit Care Med 173:1390-413. 2006
  3. pmc Effect of acute hypoxia on respiratory muscle fatigue in healthy humans
    Samuel Verges
    HP2 laboratory INSERM ERI17, Joseph Fourier University, Grenoble University Hospital, Grenoble, France
    Respir Res 11:109. 2010
    ..Hence, we assessed the effect of different blood oxygenation level on isolated hyperpnoea-induced inspiratory and expiratory muscle fatigue...
  4. pmc A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Rd, London SW3 6NP, UK
    Respir Res 8:25. 2007
    ..We therefore prospectively investigated the impact of disease severity, exacerbation frequency and treatment with corticosteroids on change in body composition and maximum isometric quadriceps strength (QMVC) over one year...
  5. ncbi The effects of 1 year of specific inspiratory muscle training in patients with COPD
    Marinella Beckerman
    Department of Medicine A, Hillel Yaffe Medical Center, Hadera, Israel
    Chest 128:3177-82. 2005
    ..We assessed the long-term benefits of inspiratory muscle training (IMT) on inspiratory muscle strength, exercise capacity, the perception of dyspnea, quality of life, primary care use, and hospitalizations in patients with significant COPD...
  6. ncbi Comparative assessment of the quadriceps and the diaphragm in patients with COPD
    Marc André Caron
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada G1V 4G5
    J Appl Physiol (1985) 107:952-61. 2009
    ..Several studies have highlighted important structural and biochemical modifications in limb and respiratory muscles in COPD...
  7. ncbi +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Road, London SW3 6NP, United Kingdom
    Am J Clin Nutr 83:912-7. 2006
    ....
  8. ncbi Ubiquitination and proteolysis in limb and respiratory muscles of patients with chronic obstructive pulmonary disease
    Richard Debigare
    P T, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725, Chemin Ste Foy, PQ, G1V 4G5 Canada
    Proc Am Thorac Soc 7:84-90. 2010
    ..Based on this information, the reader should be able to understand the essential role of this pathway in the context of muscle homeostasis and to picture the coming research in this area...
  9. ncbi Inspiratory muscle training increases inspiratory muscle strength in patients weaning from mechanical ventilation: a systematic review
    Lisa Moodie
    Auckland District Health Board, New Zealand
    J Physiother 57:213-21. 2011
    ..Does inspiratory muscle training improve inspiratory muscle strength and endurance, facilitate weaning, improve survival, and reduce the rate of reintubation and tracheostomy in adults receiving mechanical ventilation?..
  10. pmc Nutritional status is related to fat-free mass, exercise capacity and inspiratory strength in severe chronic obstructive pulmonary disease patients
    Pollyane Galinari Sabino
    Department of Physical Therapy, Londrina State University, Parana, Brazil
    Clinics (Sao Paulo) 65:599-605. 2010
    ..This paradoxical relationship indicates that the influence of nutritional status on functional parameters should be further investigated...
  11. pmc Patterns of expiratory and inspiratory activation for thoracic motoneurones in the anaesthetized and the decerebrate rat
    Anoushka T R de Almeida
    Sobell Department, UCL Institute of Neurology, University College London, Queen Square, London, UK
    J Physiol 588:2707-29. 2010
    ....
  12. ncbi Ventilator-induced diaphragmatic dysfunction
    Theodoros Vassilakopoulos
    Respiratory Division, McGill University Health Center, McGill University, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 169:336-41. 2004
  13. ncbi Inspiratory muscle training in patients with chronic obstructive pulmonary disease: structural adaptation and physiologic outcomes
    Alba Ramirez-Sarmiento
    Servei de Pneumologia, Hospital del Mar Grup de Recerca de Pneumologia, Unitat de Recerca Respiratoria i Ambiental, Barcelona, Spain
    Am J Respir Crit Care Med 166:1491-7. 2002
    ..No changes were observed in the control muscle. The study demonstrates that inspiratory training induces a specific functional improvement of the inspiratory muscles and adaptive changes in the structure of external intercostal muscles...
  14. ncbi Restoration of respiratory muscle function following spinal cord injury. Review of electrical and magnetic stimulation techniques
    Anthony F DiMarco
    Department of Physiology and Biophysics, Case Western Reserve University, MetroHealth Medical Center, Rammelkamp Center for Education and Research, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    Respir Physiol Neurobiol 147:273-87. 2005
    ..These techniques hold promise to reduce the incidence of respiratory tract infections, atelectasis and respiratory failure in patients with spinal cord injury and reduce the morbidity and mortality associated with these complications...
  15. ncbi New reference values for maximal respiratory pressures in the Brazilian population
    Dirceu Costa
    Universidade Federal de Sao Carlos, Federal University of Sao Carlos, Sao Carlos, SP, Brazil
    J Bras Pneumol 36:306-12. 2010
    ..To compare MIP and MEP determined in healthy subjects with those predicted using the equations proposed in another study, and, if necessary, to suggest new equations for MIP and MEP to be used in the Brazilian population...
  16. pmc Impact of pulmonary system limitations on locomotor muscle fatigue in patients with COPD
    Markus Amann
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison Medical School, Madison, Wisconsin, USA
    Am J Physiol Regul Integr Comp Physiol 299:R314-24. 2010
    ....
  17. ncbi Intercostal and abdominal respiratory motoneurons in the neonatal rat spinal cord: spatiotemporal organization and responses to limb afferent stimulation
    Aurore Giraudin
    Universite Victor Segalen Bordeaux 2, UMR CNRS 5227, Laboratoire Mouvement Adaptation Cognition, Bâtiment 2A, 146 rue Leo Saignat, Bordeaux, France
    J Neurophysiol 99:2626-40. 2008
    ....
  18. pmc Multiple phases of excitation and inhibition in central respiratory drive potentials of thoracic motoneurones in the rat
    Anoushka T R de Almeida
    Sobell Department, UCL Institute of Neurology, University College London, Queen Square, London, UK
    J Physiol 588:2731-44. 2010
    ..They also provide new insights into the functional roles of inhibition in motoneurones physiologically activated in natural rhythmic behaviours...
  19. ncbi The effect of inspiratory muscles fatigue on postural control in people with and without recurrent low back pain
    Lotte Janssens
    Musculoskeletal Research Unit, Department of Rehabilitation Sciences, University of Leuven K U Leuven, Tervuursevest 101, Leuven, Belgium
    Spine (Phila Pa 1976) 35:1088-94. 2010
    ..A 2-group experimental design...
  20. ncbi Inspiratory muscle training in pulmonary rehabilitation program in COPD patients
    Rasmi Magadle
    Department of Medicine A, Hillel Yaffe Medical Center, Hadera 38100, Israel
    Respir Med 101:1500-5. 2007
    ..IMT provides additional benefits to patients undergoing PR program and is worthwhile even in patients who have already undergone a GER program...
  21. ncbi Postural and respiratory activation of the trunk muscles changes with mode and speed of locomotion
    Steven W Saunders
    School of Physiotherapy, The University of South Australia, Adelaide, Australia
    Gait Posture 20:280-90. 2004
    ..Furthermore, the pattern of recruitment of the trunk muscles and their respiratory and postural coordination is dependent on the speed and mode of locomotion...
  22. ncbi Respiratory muscle function and activation in chronic obstructive pulmonary disease
    David K McKenzie
    Department of Respiratory and Sleep Medicine, Prince of Wales Medical Research Institute, Prince of Wales Hospital and University of New South Wales, Barker St, Randwick, NSW 2031, Australia
    J Appl Physiol (1985) 107:621-9. 2009
    ..The improvement in exercise capacity and dyspnea following lung volume reduction surgery is associated with a substantial reduction in neural drive to the inspiratory muscles...
  23. ncbi The role of spinal manipulation, soft-tissue therapy, and exercise in chronic obstructive pulmonary disease: a review of the literature and proposal of an anatomical explanation
    Roger Engel
    Department of Chiropractic, Macquarie University, Sydney, New South Wales, Australia
    J Altern Complement Med 17:797-801. 2011
    ..Improvements in breathing mechanics reduce the work of the respiratory muscles and delay the onset of dyspnea...
  24. ncbi Respiratory muscle training in healthy humans: resolving the controversy
    A K McConnell
    Department of Sport Sciences, Brunel University, Uxbridge, Middlesex, UK
    Int J Sports Med 25:284-93. 2004
    ..Putative mechanisms include a delay of respiratory muscle fatigue, a redistribution of blood flow from respiratory to locomotor muscles, and a decrease in the perceptions of respiratory and limb discomfort...
  25. ncbi Effect of bronchoscopic lung volume reduction on dynamic hyperinflation and exercise in emphysema
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Department of Respiratory Medicine, Royal Brompton Hospital, Fulham Road, London SW3 6NP, UK
    Am J Respir Crit Care Med 171:453-60. 2005
    ..47; p = 0.03). Endobronchial valve placement can improve lung volumes and gas transfer in patients with chronic obstructive pulmonary disease and prolong exercise time by reducing dynamic hyperinflation...
  26. pmc Determinants of weaning success in patients with prolonged mechanical ventilation
    Annalisa Carlucci
    Respiratory Intensive Care Unit, Fondazione S, Maugeri, IRCCS, Pavia 27100, Italy
    Crit Care 13:R97. 2009
    ..In this physiological study, we assessed the determinants of weaning success in patients acting as their own control, once they are eventually liberated from the ventilator...
  27. pmc Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial
    A Daniel Martin
    Department of Physical Therapy, University of Florida, 1600 South West Archer Road, PO Box 100154, Gainesville, FL 32610, USA
    Crit Care 15:R84. 2011
    ..MV induced inspiratory muscle weakness has been implicated as a contributor to FTW and recent work has documented inspiratory muscle weakness in humans supported with MV...
  28. ncbi Consequences of exercise-induced respiratory muscle work
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, Madison, WI 53706, USA
    Respir Physiol Neurobiol 151:242-50. 2006
    ..Clinical implications for respiratory limitations to exercise in patients with chronic obstructive lung disease (COPD) and chronic heart failure (CHF) are discussed and key unresolved problems are outlined...
  29. pmc Effects of chest physiotherapy on the respiratory function of postoperative gastroplasty patients
    Eli Forti
    Postgraduate program in Physical Therapy, Federal University of Sao Carlos UFSCar, Sao Carlos SP, Brazil
    Clinics (Sao Paulo) 64:683-9. 2009
    ....
  30. ncbi Effects of respiratory muscle work on exercise performance
    C A Harms
    John Rankin Laboratory of Pulmonary Medicine, Department Preventive Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 89:131-8. 2000
    ....
  31. ncbi Corticospinal control of respiratory muscles in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, London SW3 6NP, UK
    Respir Physiol Neurobiol 141:1-12. 2004
    ..These results suggest that there is a ceiling effect in motor control output to the respiratory muscles of patients with COPD.
  32. ncbi Structure and function of the respiratory muscles in patients with COPD: impairment or adaptation?
    M Orozco-Levi
    Muscle Research Unit, Servei de Pneumologia, Hospital del Mar, Institut Municipal d Investigacio Medica, CEXS Universitat Pompeu Fabra, Carrer Dr Aiguader, 80 Barcelona, E 08003 Spain
    Eur Respir J Suppl 46:41s-51s. 2003
    b>Respiratory muscles are essential to alveolar ventilation. These muscles work against increased mechanical loads due to airflow limitation and geometrical changes of the thorax derived from pulmonary hyperinflation...
  33. ncbi Nasal continuous positive airway pressure decreases respiratory muscles overload in young infants with severe acute viral bronchiolitis
    Gilles Cambonie
    Pediatric Intensive Care Unit, CHU Montpellier, 34000 Montpellier, France
    Intensive Care Med 34:1865-72. 2008
    ..To determine the efficacy of nasal continuous positive airway pressure (nCPAP) on respiratory distress symptoms and respiratory effort in young infants with acute respiratory syncytial virus bronchiolitis...
  34. ncbi Respiratory muscle endurance training in chronic obstructive pulmonary disease: impact on exercise capacity, dyspnea, and quality of life
    T A Scherer
    Department of Internal Medicine, Triemli Hospital, Zurich, Switzerland
    Am J Respir Crit Care Med 162:1709-14. 2000
    ..In conclusion, home-based respiratory muscle endurance training with the new device used in this study is feasible and has beneficial effects in subjects with COPD and ventilatory limitation...
  35. ncbi Consequences of the combined deficiency in dystrophin and utrophin on the mechanical properties and myosin composition of some limb and respiratory muscles of the mouse
    N Deconinck
    Department de Physiologie, Universite Catholique de Louvain, Bruxelles, Belgium
    Neuromuscul Disord 8:362-70. 1998
    ..Moreover these results bring some support to the idea that the expression of utrophin in mdx muscle compensates, to some extent, for the lack of dystrophin...
  36. ncbi Chronic respiratory failure in patients with neuromuscular diseases: diagnosis and treatment
    Ilma Aparecida Paschoal
    Pulmonology Department, State University at Campinas, School of Medical Sciences, Campinas, SP, Brazil
    J Bras Pneumol 33:81-92. 2007
    ..Moreover, the maneuvers used to increase cough efficiency, as well as the proper timing of their introduction, are discussed...
  37. ncbi Efficacy of nutritional supplementation therapy in depleted patients with chronic obstructive pulmonary disease
    Eva C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Nutrition 19:120-7. 2003
    ..Maintenance systemic glucocorticosteroids, prescribed in a substantial number of patients, further contribute to muscle weakness. We investigated the efficacy of oral nutritional supplementation therapy in depleted patients with COPD...
  38. ncbi Inspiratory muscle strength in chronic obstructive pulmonary disease depending on disease severity
    Hans Joachim Kabitz
    Department of Pneumology, University Hospital Freiburg, Freiburg, Germany
    Clin Sci (Lond) 113:243-9. 2007
    ..57; P<0.001). Inspiratory muscle strength, as reliably assessed by TwPmo, decreased with increasing severity of COPD and should be considered as an important factor in rating disease severity and to reflect burden in COPD...
  39. ncbi Maintenance of inspiratory muscle training in COPD patients: one year follow-up
    P Weiner
    Dept of Medicine A, Hillel Yaffe Medical Center, Hadera, Israel
    Eur Respir J 23:61-5. 2004
    ..The benefits of 12-weeks of inspiratory muscle training decline gradually over 1 yr of follow-up if maintenance training is not performed...
  40. ncbi Using an evidence-based protocol to guide rehabilitation and weaning of ventilator-dependent cervical spinal cord injury patients
    Charles J Gutierrez
    Department of Respirator, Care and Diagnostic Services, Spinal Cord Injury Disorder Service, Spinal Cord Injury, Center, James A Haley Veterans Hospital, Tampa, FL 33612, USA
    J Rehabil Res Dev 40:99-110. 2003
    ....
  41. ncbi [The effect of hyperinflation on respiratory muscles and breathing pattern in COPD]
    Oznur Akkoca
    Ankara University Faculty of Medicine, Pulmonary Diseases, Ankara, Turkey
    Tuberk Toraks 51:244-52. 2003
    ..The aim of this study was to investigate the influence of hyperinflation on respiratory muscles, gas transfer and breathing pattern and compare the differences between mild and severe COPD...
  42. ncbi Effects of respiratory muscle training versus placebo on endurance exercise performance
    D A Sonetti
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, 504 N. Walnut Street, Madison, WI 53705, USA
    Respir Physiol 127:185-99. 2001
    ..Significant placebo and test familiarization effects must be accounted for in experimental designs utilizing performance tests which are critically dependent on volitional effort...
  43. ncbi Adenotonsillectomy improves the strength of respiratory muscles in children with upper airway obstruction
    Melissa Guerato Pires Banzatto
    University of Sao Paulo, School of Medicine, Brazil
    Int J Pediatr Otorhinolaryngol 74:860-3. 2010
    ..Children were evaluated in 3 different moments: 1 week before and 3 and 6 months after surgery...
  44. ncbi Respiratory muscle endurance training in obese patients
    J C Villiot-Danger
    HP2 Laboratory, INSERM ERI17, Joseph Fourier University, Grenoble, France
    Int J Obes (Lond) 35:692-9. 2011
    ..We evaluated the effect of respiratory muscle endurance training (RMET) on respiratory muscle capacities, symptoms and exercise capacity in obese patients...
  45. ncbi Coordination between breathing and forearm movements during sinusoidal tracking
    D Ebert
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstrasse 27, D 04103 Leipzig, Germany
    Eur J Appl Physiol 81:288-96. 2000
    ..The frequency of coordination between breathing and rhythmical tracking movements depends critically upon the movement rate...
  46. ncbi Respiratory parameters during professional flute playing
    I Cossette
    Meakins Christie Laboratories, McGill University, 3626 rue St Urbain, Quebec, H2X 2PZ, Montreal, Canada
    Respir Physiol 121:33-44. 2000
    We studied three professional flautists while playing to determine: (1) what respiratory muscles and percent vital capacity (%VC) were used; (2) how mouth pressure (Pm), embouchure resistance (Rem), embouchure aperture (Aem), flow (V) ..
  47. ncbi Drive to the human respiratory muscles
    Jane E Butler
    Prince of Wales Medical Research Institute, University of New South Wales, Sydney, NSW 2031, Australia
    Respir Physiol Neurobiol 159:115-26. 2007
    The motor control of the respiratory muscles differs in some ways from that of the limb muscles...
  48. ncbi Experimental approaches to the study of the mechanics of breathing during exercise
    Paolo B Dominelli
    School of Kinesiology, The University of British Columbia, 6108 Thunderbird Blvd, Vancouver, BC, Canada V6T 1Z3
    Respir Physiol Neurobiol 180:147-61. 2012
    ..Finally, recent technological advancements that contribute to the understanding of respiratory mechanics are explained...
  49. ncbi Impact of obesity on exercise performance and pulmonary rehabilitation
    Michael Dreher
    Department of Pneumology, University Hospital, Freiburg, Germany
    Respirology 17:899-907. 2012
    ..Otherwise, there are no conclusive data on the impact of obesity on PR in respiratory disorders other than COPD, and this remains to be investigated in the future...
  50. pmc Lower thoracic spinal cord stimulation to restore cough in patients with spinal cord injury: results of a National Institutes of Health-sponsored clinical trial. Part I: methodology and effectiveness of expiratory muscle activation
    Anthony F DiMarco
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA
    Arch Phys Med Rehabil 90:717-25. 2009
    ..Evaluation of the capacity of lower thoracic spinal cord stimulation (SCS) to activate the expiratory muscles and generate large airway pressures and high peak airflows characteristic of cough, in subjects with tetraplegia...
  51. ncbi Does using pressure-controlled ventilation to rest respiratory muscles improve sleep in ICU patients?
    Claire Andrejak
    Respiratory Intensive Care Unit, Centre Hospitalier Universitaire Sud, Amiens, France
    Respir Med 107:534-41. 2013
    ..Ventilatory mode may impact on quality of sleep. The aim of our study was to evaluate the effect on sleep of pressure-controlled ventilation (PCV) to spontaneous ventilation with 6 cm H2O inspiratory pressure (low-PSV)...
  52. ncbi Respiratory muscle unloading improves leg muscle oxygenation during exercise in patients with COPD
    A Borghi-Silva
    Pulmonary Function and Clinical Exercise Physiology Unit, Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
    Thorax 63:910-5. 2008
    ..Respiratory muscle unloading during exercise could improve locomotor muscle oxygenation by increasing oxygen delivery (higher cardiac output and/or arterial oxygen content) in patients with chronic obstructive pulmonary disease (COPD)...
  53. ncbi Comparison of respiratory muscle training methods in individuals with motor and sensory complete tetraplegia: a randomized controlled trial
    Gabi Mueller
    Clinical Trial Unit, Swiss Paraplegic Center, CH 6207 Nottwil, Switzerland
    J Rehabil Med 45:248-53. 2013
    ..To compare the effects of inspiratory resistance training and isocapnic hyperpnoea vs incentive spirometry (placebo) on respiratory function, voice, thorax mobility and quality of life in individuals with tetraplegia...
  54. pmc Neuromuscular ultrasound for evaluation of the diaphragm
    Aarti Sarwal
    Department of Neurology, Wake Forest School of Medicine, Reynolds M, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Muscle Nerve 47:319-29. 2013
    ..In this study we review different techniques for assessing the diaphragm using neuromuscular ultrasound and the application of these techniques to enhance diagnosis and prognosis by neuromuscular clinicians...
  55. ncbi Non-invasive assessment of respiratory muscle strength in patients with previous poliomyelitis
    Mohamed Gouda Soliman
    Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, Lane Fox Unit, Lambeth Palace Road, London SE1 7EH, UK
    Respir Med 99:1217-22. 2005
    ..Some patients continue to require long-term nocturnal ventilatory support; others are weaned but subsequently require support because of a late deterioration in ventilatory function...
  56. ncbi Respiratory muscle fatigue following exercise in patients with interstitial lung disease
    Davide Elia
    NIHR Respiratory Biomedical Research Unit at Royal Brompton and Harefield NHS Foundation Trust and Imperial College, Royal Brompton Hospital, London, UK
    Respiration 85:220-7. 2013
    ..It is not known whether respiratory muscle fatigue occurs as a consequence of exercise in patients with interstitial lung disease (ILD) and, if so, to what extent it is related to changes in dynamic lung volumes...
  57. ncbi Respiratory muscle training in healthy individuals: physiological rationale and implications for exercise performance
    A William Sheel
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada bill sheel ubc ca
    Sports Med 32:567-81. 2002
    ..suggest that specific respiratory muscle (RM) training can improve the endurance and strength of the respiratory muscles in healthy humans. The effects of RM training on exercise performance remains controversial...
  58. ncbi Specific respiratory warm-up improves rowing performance and exertional dyspnea
    S Volianitis
    School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Med Sci Sports Exerc 33:1189-93. 2001
    ..The purpose of this study was a) to compare the effect of three different warm-up protocols upon rowing performance and perception of dyspnea, and b) to identify the functional significance of a respiratory warm-up...
  59. ncbi The effect of inspiratory and expiratory respiratory muscle training in rowers
    S Forbes
    Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
    Res Sports Med 19:217-30. 2011
    ..The experimental group trained respiratory muscles using a device that provided both an inspiratory and expiratory resistance while the control group used a ..
  60. pmc Phasic motor activity of respiratory and non-respiratory muscles in REM sleep
    Jimmy J Fraigne
    Texas Tech University Health Sciences Center School of Medicine, Department of Cell Physiology and Molecular Biophysics, Lubbock TX, USA
    Sleep 34:425-34. 2011
    In this study, we quantified the profiles of phasic activity in respiratory muscles (diaphragm, genioglossus and external intercostal) and non-respiratory muscles (neck and extensor digitorum) across REM sleep...
  61. pmc The gross morphology and histochemistry of respiratory muscles in bottlenose dolphins, Tursiops truncatus
    Pamela B Cotten
    Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, North Carolina 28403, USA
    J Morphol 269:1520-38. 2008
    ..These combined results suggest that dolphins utilize muscles, similar to those used by galloping mammals, to power their explosive ventilation...
  62. ncbi Effect of respiratory muscle training on exercise performance in healthy individuals: a systematic review and meta-analysis
    Sabine K Illi
    Exercise Physiology, Institute of Human Movement Sciences, ETH Zurich, Zurich, Switzerland
    Sports Med 42:707-24. 2012
    ..We performed a systematic review and meta-analysis in order to determine the factors that affect the change in endurance performance after RMT in healthy subjects...
  63. ncbi Integrated approach for in vivo evaluation of respiratory muscles mechanics
    Anat Ratnovsky
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech 36:1771-84. 2003
    The respiratory muscles constitute the respiratory pump, which determines the efficacy of ventilation. Any functional disorder in their performance may cause insufficient ventilation...
  64. ncbi High-intensity inspiratory muscle training in patients with chronic obstructive pulmonary disease and severely reduced function
    M K Covey
    University of Illinois at Chicago, College of Nursing, 845 South Damen Avenue, Chicago, IL, USA
    J Cardiopulm Rehabil 21:231-40. 2001
    ..This study examined the effects of inspiratory muscle training (IMT) with high-intensity inspiratory pressure loads on respiratory muscle performance and exertional dyspnea...
  65. ncbi The respiratory muscles in eucapnic obesity: their role in dyspnea
    Giorgio Scano
    Fondazione Don C Gnocchi, Pozzolatico, Florence, Italy
    Respir Med 103:1276-85. 2009
    ..That a decrease in efficiency of the respiratory muscles during exercise contributes to dyspnea in hyperinflating obese subjects should not be disregarded.
  66. ncbi High-intensity inspiratory muscle training in COPD
    K Hill
    Dept of Pulmonary Physiology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia, 6009 Australia
    Eur Respir J 27:1119-28. 2006
    ..In conclusion, high-intensity inspiratory muscle training improves inspiratory muscle function in subjects with moderate-to-severe chronic obstructive pulmonary disease, yielding meaningful reductions in dyspnoea and fatigue...
  67. ncbi Expression of myosin heavy-chain isoforms in the respiratory muscles following inspiratory resistive breathing
    J Gea
    Centre de Recherche du CHUM, Université de Montréal and Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 161:1274-8. 2000
    ..IRB) on the expression of the genes encoding fast and slow isoforms of myosin heavy chain (MyHC) in respiratory muscles. Eleven mongrel dogs were studied for baseline MyHC messenger RNA (mRNA) expression, seven of which were ..
  68. ncbi Respiratory disturbance to posture varies according to the respiratory mode
    Alain Hamaoui
    Laboratory of Posture and Movement Physiology, University JF Champollion, Rodez, France LAPMA, University Paul Sabatier, Toulouse, France
    Neurosci Lett 475:141-4. 2010
    ..It was concluded that respiratory kinematics have a more prominent disturbing effect on posture when they involve the rib cage rather than the abdomen...
  69. ncbi Mechanics of respiratory muscles
    Anat Ratnovsky
    Department of Medical Engineering, Afeka College of Engineering, Tel Aviv 69107, Israel
    Respir Physiol Neurobiol 163:82-9. 2008
    Lung ventilation is a mechanical process in which the respiratory muscles are acting in concert to remove air in and out of the lungs...
  70. ncbi Effects of inspiratory muscle training on time-trial performance in trained cyclists
    Lee M Romer
    The Human Performance Laboratory, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, UK
    J Sports Sci 20:547-62. 2002
    ..Furthermore, they provide evidence of performance enhancements in competitive cyclists after inspiratory muscle training...
  71. ncbi Inspiratory muscle training in patients with COPD: effect on dyspnea, exercise performance, and quality of life
    H Sánchez Riera
    Pneumology Service, Virgen del Rocio University Hospital, Sevilla, Spain
    Chest 120:748-56. 2001
    ..The aim of the study was to assess the effect of target-flow inspiratory muscle training (IMT) on respiratory muscle function, exercise performance, dyspnea, and health-related quality of life (HRQL) in patients with COPD...
  72. ncbi Muscular patterns and activation levels of auxiliary breathing muscles and thorax movement in classical singing
    Viggo Pettersen
    Department of Music and Dance, University of Stavanger, Stavanger, Norway
    Folia Phoniatr Logop 57:255-77. 2005
    ..Substantial muscle activity is observed in PN during inhalation and phonation. EMG biofeedback performed on TR and STM have a secondary effect of lowering EMG activity in PN...
  73. ncbi Abdominal volume contribution to tidal volume as an early indicator of respiratory impairment in Duchenne muscular dystrophy
    A Lo Mauro
    TBM Lab, Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy
    Eur Respir J 35:1118-25. 2010
    ..DeltaV(AB) is not only an important marker of the progression of the disease but is also an early indicator of nocturnal hypoxaemia...
  74. ncbi Respiratory muscles, exercise performance, and health in overweight and obese subjects
    Irene Frank
    Exercise Physiology, Institute of Human Movement Sciences, ETH Zurich, and Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Med Sci Sports Exerc 43:714-27. 2011
    ..We hypothesized that RMET 1 month before and during a 6-month (3 months supervised + 3 months unsupervised) exercise and nutrition counseling program (EN) would improve the benefits of EN...
  75. ncbi Lung and respiratory muscle function in facioscapulohumeral muscular dystrophy
    Joerg Patrick Stübgen
    Department of Neurology, University of Pretoria, Pretoria, South Africa
    Muscle Nerve 39:729-34. 2009
    ..It is probably not necessary to routinely monitor respiratory muscle function in ambulant FSHD patients who lack symptoms or signs of respiratory impairment...
  76. ncbi Differential activation among five human inspiratory motoneuron pools during tidal breathing
    Julian P Saboisky
    Prince of Wales Medical Research Inst and University of New South Wales, Sydney, Australia
    J Appl Physiol 102:772-80. 2007
    ..05). There was a unimodal distribution of recruitment times of motor units in all muscles. Neural drive to human inspiratory pump muscles differs in timing, strength, and distribution, presumably to achieve efficient ventilation...
  77. ncbi Breathing more with weaker respiratory muscles in pulmonary arterial hypertension
    R Naeije
    Eur Respir J 25:6-8. 2005
  78. ncbi Inspiratory strengthening effect on resistive load detection and magnitude estimation
    B A Kellerman
    Departments of Physical Therapy and Physiological Sciences, University of Florida, Gainesville 32610, USA
    Med Sci Sports Exerc 32:1859-67. 2000
    ..This study investigated effects of inspiratory muscle training (IMT) on maximal inspiratory pressure (MIP), magnitude estimation (ME), and load detection (LD) of external resistive loads (deltaR) in healthy subjects...
  79. pmc Fatiguing inspiratory muscle work causes reflex reduction in resting leg blood flow in humans
    A W Sheel
    Department of Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison, Madison, WI, USA
    J Physiol 537:277-89. 2001
    ..Q(L) and increases in LVR. We attribute these changes to a metaboreflex originating in the diaphragm. Diaphragm and forearm muscle fatigue showed very similar time-dependent effects on LVR and .Q(L)...
  80. pmc Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis
    Harry R Gosker
    Department of Respiratory Medicine, NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Thorax 62:944-9. 2007
    ..A study was conducted to determine whether vastus lateralis muscle fibre type proportions are associated with COPD disease severity and to provide reference values for the proportions of fibre types in the vastus lateralis in COPD...
  81. ncbi Breathlessness, fatigue and the respiratory muscles
    John Mioxham
    King s College London School of Medicine
    Clin Med 9:448-52. 2009
    ..underlying the symptom can be gained by considering the balance between the load on, and capacity of, the respiratory muscles and increased neural respiratory drive, reflecting increased respiratory effort...
  82. pmc Pre-operative inspiratory muscle training preserves postoperative inspiratory muscle strength following major abdominal surgery - a randomised pilot study
    S R Kulkarni
    Department of General and Vascular Surgery, Cheltenham General Hospital, Cheltenham GL53 7AN, UK
    Ann R Coll Surg Engl 92:700-7. 2010
    ..The aim of this pilot study was to assess the effect of pre-operative inspiratory muscle training (IMT) on respiratory variables in patients undergoing major abdominal surgery...
  83. ncbi Impact of obstructive apnea syndrome on upper airway respiratory muscles
    Eva Svanborg
    Department of Clinical Neurophysiology, University Hospital, 581 85 Linkoping, Sweden
    Respir Physiol Neurobiol 147:263-72. 2005
    ..This supports the hypothesis that progression from habitual snoring to the clinical disease of OSAS could be attributed to peripheral neurogenic lesions...
  84. ncbi Abnormal mitochondrial function in locomotor and respiratory muscles of COPD patients
    L Puente-Maestu
    Servicio de Neumologia, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Eur Respir J 33:1045-52. 2009
    Several cellular and molecular alterations have been described in skeletal and respiratory muscles of patients with chronic obstructive pulmonary disease (COPD), but information on potential abnormalities of mitochondrial function is ..
  85. ncbi Role of the respiratory muscles in acute respiratory failure of COPD: lessons from weaning failure
    Martin J Tobin
    Division of Pulmonary and Critical Care Medicine, Edward Hines Jr VA Hospital, Hines, Illinois 60141, USA
    J Appl Physiol (1985) 107:962-70. 2009
    ..Although the disease originates within the lung parenchyma, much of the distress faced by patients with COPD, especially during acute respiratory failure, is caused by the burdens imposed on the respiratory muscles.
  86. ncbi Measuring inspiratory muscle strength in neuromuscular disease: one test or two?
    N Terzi
    Intensive Care Unit, Dept of Physiology Functional Testing and Centre for Technological Innovation, Raymond Poincaré Teaching Hospital, Garches, France
    Eur Respir J 31:93-8. 2008
    ..However, when sniff nasal inspiratory pressure measurement yields the best value at baseline, using sniff nasal inspiratory pressure alone during follow-up may be appropriate...
  87. ncbi Arm work interferes with normal ventilation
    Frank J Cerny
    Department of Exercise and Nutrition Sciences, University at Buffalo, 410 Kimball Tower, NY 14214, USA
    Appl Ergon 35:411-5. 2004
    Arm work, by limiting movement of the chest wall and use of the respiratory muscles, may alter breathing pattern and gas exchange sufficiently to interfere with the ability to perform certain tasks...
  88. ncbi Control of breathing in mechanically ventilated patients
    D Georgopoulos
    Pulmonary and Critical Care Dept General Hospital G Papanicolaou, University of Thessaloniki, Greece
    Eur Respir J 9:2151-60. 1996
    ..the respiratory system is under the influence of two pumps, the ventilator pump and the patient's own respiratory muscles. Depending on the mode of mechanical ventilatory support, ventilation may be totally controlled by the ..
  89. ncbi Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise
    C A Harms
    Department of Preventive Medicine, John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 85:609-18. 1998
    ..exercise has two significant effects on the cardiovascular system: 1) up to 14-16% of the CO is directed to the respiratory muscles; and 2) local reflex vasoconstriction significantly compromises blood flow to leg locomotor muscles.
  90. ncbi Respiratory muscle training increases cycling endurance without affecting cardiovascular responses to exercise
    G Markov
    Institute for Human Movement Sciences, Swiss Federal Institute of Technology, Institute of Physiology, University of Zurich, Winterthurerstr. 190, 8057 Zurich, Switzerland
    Eur J Appl Physiol 85:233-9. 2001
    ..It is concluded that the increased cycling endurance that is observed after RMT is not due to cardiovascular adaptations, and that the results provide evidence for the role of the respiratory system as an exercise-limiting factor...
  91. ncbi Diaphragmatic fatigue during sepsis and septic shock
    Sophie Lanone
    INSERM U 700 and IFR 02, Faculte Xavier Bichat, 16 rue Henri Huchard, 75018, Paris, France
    Intensive Care Med 31:1611-7. 2005
  92. pmc Respiratory muscle fibres: specialisation and plasticity
    B Polla
    Hospital S Biagio, Department of Pneumology, Alessandria, Italy
    Thorax 59:808-17. 2004
    ..The properties of respiratory muscle fibres can also be modified by pharmacological agents such as beta2 agonists and corticosteroids used for the treatment of respiratory diseases...
  93. ncbi Response of the respiratory muscles to rehabilitation in COPD
    Marc Decramer
    Respiratory Division, University Hospital, University of Leuven, 3000 Leuven, Belgium
    J Appl Physiol (1985) 107:971-6. 2009
    ..Eight randomized studies examined the effects of the combination. Greater improvements in exercise capacity were only found in three studies, and none showed a greater reduction in dyspnea...
  94. ncbi [Clinical consequences of muscle dysfunction in chronic obstructive pulmonary disease]
    J Sauleda Roig
    Servei Pneumologia Hospital Son Dureta, Palma de Mallorca
    Nutr Hosp 21:69-75. 2006
    The function of respiratory muscles, and mainly inspiratory muscles, is impaired in COPD patients. Most of these impairments are essentially due to pulmonary hyperinflation that puts these muscles in a disadvantageous situation...
  95. ncbi Gene expression microarrays and respiratory muscles
    Erik van Lunteren
    Division of Pulmonary, Critical Care and Sleep Medicine, Cleveland VA Medical Center and Case Western Reserve University, Cleveland, OH 44106, United States
    Respir Physiol Neurobiol 156:103-15. 2007
    ....
  96. ncbi Prevalence of reduced respiratory muscle strength in institutionalized elderly people
    Rodrigo Polaquini Simões
    Postgraduate Program on Physiotherapy, Cardiopulmonary Physiotherapy Laboratory, Universidade Federal de Sao Carlos, Sao Carlos, Sao Paulo, Brazil
    Sao Paulo Med J 127:78-83. 2009
    ....
  97. pmc Mechanisms of improvement of respiratory failure in patients with restrictive thoracic disease treated with non-invasive ventilation
    A H Nickol
    Osler Chest Unit, Churchill Hospital, Headington, Oxford OX4 7LJ, UK
    Thorax 60:754-60. 2005
    ..We hypothesised that NIV may reverse respiratory failure by increasing the ventilatory response to carbon dioxide, reducing inspiratory muscle fatigue, or enhancing pulmonary mechanics...
  98. ncbi Long-term reduction of hyperinflation in stable COPD by non-invasive nocturnal home ventilation
    Stephan Budweiser
    Fachklinik für Erkrankungen der Atmungsorgane, Donaustauf, Germany
    Respir Med 99:976-84. 2005
    ..The role of non-invasive positive pressure ventilation (NPPV) in stable COPD with chronic ventilatory failure remains controversial. The impact of long-term home nocturnal NPPV treatment on deflation has not yet been evaluated in detail...
  99. ncbi Effects of respiratory muscle unloading on exercise-induced diaphragm fatigue
    Mark A Babcock
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison 53706 2368, USA
    J Appl Physiol 93:201-6. 2002
    ..In this study, we use positive-pressure proportional assist ventilation (PAV) to unload the respiratory muscles during exercise to determine the effects of respiratory muscle work, per se, on exercise-induced ..
  100. ncbi The Italian multicentre study on noninvasive ventilation in chronic obstructive pulmonary disease patients
    E Clini
    Division of Pulmonary Rehabilitation, Fondazione Villa Pineta ONLUS, Pavullo MO, Italy
    Eur Respir J 20:529-38. 2002
    ..Further work is required to evaluate the effect of noninvasive positive-pressure ventilation on reducing the frequency and severity of chronic obstructive pulmonary disease exacerbation...
  101. ncbi Impact of expiratory trigger setting on delayed cycling and inspiratory muscle workload
    Didier Tassaux
    Medical Intensive Care, University Hospital, Geneva, Switzerland
    Am J Respir Crit Care Med 172:1283-9. 2005
    ..In obstructive disease, the slower rise and decrease of inspiratory flow entails delayed cycling, an increase in intrinsic positive end-expiratory pressure, and nontriggering breaths...

Research Grants64

  1. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles.
  2. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ....
  3. Pharmacological strategies to improve breathing after cervical spinal cord injury
    FRANCIS GOLDER; Fiscal Year: 2009
    ..injury causes life-threatening respiratory failure by decreasing function of the neural cells that control respiratory muscles, the respiratory motoneurons...
  4. Respiratory motor control and blood pressure regulation after spinal cord injury
    ALEXANDER VLADIMIROVICH OVECHKIN; Fiscal Year: 2013
    ..common impediment to rehabilitation after SCI is respiratory insufficiency due to paresis and paralysis of respiratory muscles. Physiologically, these respiratory and cardiovascular dysfunctions are closely related...
  5. Planning a Multicenter Trial of PDE5A Inhibition for Duchenne Muscular Dystrophy
    Ronald G Victor; Fiscal Year: 2012
    ....
  6. CRCNS: Computation-Enabled Adaptive Ventilatory Control System
    Ranu Jung; Fiscal Year: 2013
    ..More recently, intramuscular stimulation of multiple respiratory muscles has been proposed as a viable less surgically invasive approach, in particular for people with insufficient ..
  7. Control of Breathing and Pompe Disease
    David D Fuller; Fiscal Year: 2013
    ..in Pompe disease is that brainstem neurons and spinal cord motoneurons fail to adequately control the respiratory muscles. This renewal application targets optimization of adeno-associated virus (AAV) based therapies to treat ..
  8. Mechanisms of Respiratory Muscle Dysfunction in Heart Failure
    LEONARDO FERREIRA; Fiscal Year: 2013
    ..Aim 2. To define SMase as a mediator of diaphragm muscle dysfunction in CHF. Aim 3: To test the role of NAD(P)H oxidase on diaphragm muscle dysfunction of CHF mice. ..
  9. Physiology of Respiratory Muscle Micromechanics
    ALADIN BORIEK; Fiscal Year: 2009
    ..The completion of these aims will significantly contribute to the fundamental understanding of mechanical signal transduction in the respiratory pump. ..
  10. Therapeutic Development for Amyotrophic Lateral Sclerosis in a Canine Model
    JOAN RIPLEY COATES; Fiscal Year: 2013
    ..Patients die in 3-5 years secondary to failure of respiratory muscles. There are no effective therapies for ALS...
  11. Respiratory Muscle Weakness in Chronic Inflammation
    Francisco H Andrade; Fiscal Year: 2013
    ..The goal of this project is to identify new therapies that preserve respiratory muscle function in order to lessen illness and prolong life. ..
  12. Effect of Satellite Cell Ablation on the Aging Diaphragm
    Esther E Dupont-Versteegden; Fiscal Year: 2013
    ..However, age-related dysfunction of the respiratory muscles has an even greater impact on quality of life: impairment of the aging diaphragm disrupts a number of ..
  13. Antidote for botulism
    DAVID OWEN BEENHOUWER; Fiscal Year: 2010
    ..There is currently no treatment available that reverses BoNT-induced paralysis. The ultimate goal of these studies is to generate an effective antidote to BoNT/A intoxication. ..
  14. Mechanical ventilation, oxidative stress, and diaphragmatic atrophy
    Scott K Powers; Fiscal Year: 2012
    ..Our long-term goal is to develop methods for the prevention of MV-induced diaphragmatic weakness based on an understanding of the cellular mechanisms responsible for MV-induced diaphragmatic atrophy and contractile dysfunction. ..
  15. Mechanisms of Mutant SOD 1-Mediated Mitochondria Toxicity in the Spinal Cord of A
    Davide Trotti; Fiscal Year: 2012
    ..This leads to spasticity, hyper-reflexia, general weakness and muscle atrophy. Failure of respiratory muscles is generally the fatal event, occurring within 1 - 5 years after the onset of the first symptoms...
  16. VESTIBULAR REGULATION OF RESPIRATORY MUSCLE ACTIVITY
    Bill J Yates; Fiscal Year: 2013
    ....
  17. Evaluation and Treatment of Skeletal Muscle Weakness in Critically Ill Patients
    GERALD SUPINSKI; Fiscal Year: 2009
    ....
  18. Novel therapeutic approaches to treatment of botulinum neurotoxin poisoning
    Eric A Johnson; Fiscal Year: 2013
    ..Our current methods can produce sufficient quantities for in vitro and in vivo testing. These ABTs can be administered in a post-exposure setting by oral or inhalational routes. ..
  19. RNAi Therapy for Dominant Limb Girdle Muscular Dystrophy Type 1A
    Scott Q Harper; Fiscal Year: 2012
    ..We propose that reducing mutant myotilin in muscles will improve muscular dystrophy in LGMD1A patients. In this proposal, we will investigate a strategy to reduce mutant myotilin using gene therapy. ..
  20. Pilot Placebo-Controlled Trial of Early Noninvasive Ventilation for ALS
    Kirsten L Gruis; Fiscal Year: 2011
    ..The proposed research and educational experience will develop the candidate into an independent researcher well prepared to make fundamental contributions to ALS research in the future. ..
  21. Spinal and brainstem respiratory neurons in Pompe disease
    David D Fuller; Fiscal Year: 2013
    ..This work is a collaborative effort between a respiratory control scientist (Fuller), an AAV specialist and clinician working with Pompe patients (Byrne), and an AAV specialist with expertise in stereotaxic delivery (Mandel). ..
  22. The Multimodal Rehabilitation of Older Ventilated Survivors Of Critical Illness
    Avelino Catalino Verceles; Fiscal Year: 2013
    ..abstract_text> ..
  23. Mechanisms and therapies for respiratory muscle failure
    Ahlke Heydemann; Fiscal Year: 2013
    ..We also hypothesize that TGF2-mediated fibrosis and resultant scar tissue functionally impedes diaphragm muscle function in muscular dystrophy and other pulmonary diseases. ..
  24. Treatment of Skeletal Muscle Dysfunction in ICU Patients
    Gerald S Supinski; Fiscal Year: 2013
    ..These data support our hypotheses and suggest that the proposed studies are likely to define a new treatment that will have an important impact on the care of critically ill patients. ..
  25. Passive stretch of the chest wall in patients with Congential Muscular Dystrophy
    Raouf S Amin; Fiscal Year: 2013
    ..5. The results of this application will pave the way for the development of a future randomized control trial of daily passive stretch of the chest wall through lung hyperinsuflation in patients with neuromuscular disorders. ..
  26. Respiratory muscle work and oxidative stress in COPD: impact on leg blood flow an
    Markus Amann; Fiscal Year: 2011
    ..It is anticipated that this improvement in the rehabilitation process will prevent the deterioration of muscle function which is currently prevalent in the sedentary COPD population. ..
  27. Associations between laryngeal and cough dysfunction in bulbar amyotrophic latera
    Deanna Britton; Fiscal Year: 2012
    ..For those with limb involvement, cough dysfunction occurs due to weakened respiratory muscles. Although cough dysfunction in those with bulbar involvement is not well understood, it is recognized that ..
  28. Gene therapy in canine myotubular myopathy for clinical translation
    Martin K Childers; Fiscal Year: 2013
    ..suffice to sustain long-term functionality of striated muscles throughout the body, including the vital respiratory muscles. We propose to utilize the canine system to test this hypothesis and to optimize vector selection (Aim 1) ..
  29. Reducing Dynamic Hyperinflation through Breathing Retraining
    Eileen G Collins; Fiscal Year: 2013
    ..Multiple regression analysis will be employed to determine the predictors of improved exercise performance. ..
  30. Work of Breathing and Oxidative Stress in COPD: Impact on Blood Flow and Fatigue
    Markus Amann; Fiscal Year: 2013
    ..It is anticipated that this improvement in the rehabilitation process will prevent the deterioration of muscle function which is currently prevalent in the sedentary COPD population. ..
  31. New Directions in Biology and Disease of Skeletal Muscle
    Elizabeth M McNally; Fiscal Year: 2012
    ..abstract_text> ..
  32. Mechanisms of Respiratory Muscle Dysfunction in Heart Failure
    LEONARDO FERREIRA; Fiscal Year: 2010
    ..heart failure due to, for example, heart attack or long history of high blood pressure have weakness of the respiratory muscles that contribute to shortness of breath...
  33. Plasticity and Repair in the Phrenic Motor System
    Paul J Reier; Fiscal Year: 2013
    ..gray matter contributions to other SCI-related functional outcomes. ..
  34. Gene Therapy for Cardiac and Skeletal Myopathies
    Darin J Falk; Fiscal Year: 2011
    ..Aside from its relevance to patients with Pompe disease, this work will have a profound impact by offering a novel therapeutic option to patients who present alternative cardiovascular and skeletal muscle disease. ..
  35. MICROMECHANICS OF RESPIRATORY MUSCLES
    ALADIN BORIEK; Fiscal Year: 1999
    The respiratory muscles are a major determinant of thoracic cavity shape and; therefore, of the regional ventilation distribution. Respiratory insufficiency is the cause of death in many primary neuromuscular disorders...
  36. Mechanisms of Swallow Control of Breathing
    KENDALL FRANCIS MORRIS; Fiscal Year: 2013
    ..and activation of convergent neural elements in sCPG and rCPGs that control upper airway, pharyngeal and respiratory muscles. The sCPG must reconfigure the respiratory neural network because many of the muscles used for control of ..
  37. Pulmonary Biomarkers of Inflammation in Chronic Tetraplegia
    Miroslav Radulovic; Fiscal Year: 2009
    Persons with tetraplegia exhibit pulmonary dysfunction attributed to paralysis of respiratory muscles leading to inadequate ventilation and inability to clear secretions, predisposing this population to be more susceptible to repeated ..
  38. Mu Opioid Receptor Regulation in Neonatal Brainstem
    GEORGE OLSEN; Fiscal Year: 2006
    ..site for these effects is the nucleus tractus solitarius (NTS), which integrates sensory signals and drives respiratory muscles. Profound disturbance of neonatal breathing is a well-documented consequence of maternal opioid abuse...
  39. NURSING MODEL--RESPIRATORY MUSCLE STRENGTH IN COPD
    Janet Larson; Fiscal Year: 2001
    ..The first four variables will be measured after recovery from each exacerbation/RTI. Data will be analyzed with descriptive statistics and repeated measures ANOVA. ..
  40. RESPIRATORY PUMP FAILURE--APPLIED PHYSIOLOGY
    Rolf Hubmayr; Fiscal Year: 1992
    ..diaphragm fatigue, and b) diaphragm fatigue results from an imbalance between the mechanical load on the respiratory muscles and their endurance. Three studies are presented...
  41. HISTOINCOMPATIBLE MYOBLAST INJECTION AGAINST DYSTROPHY
    Peter Law; Fiscal Year: 1992
    ..Appropriate control experiments will be conducted. Results from this project will be compared with those obtained from implantation of histocompatible GPI-ICC myoblasts/fibroblasts...
  42. DIAPHRAGM ADAPTATIONS TO CHRONIC RESISTIVE LOADING
    David Prezant; Fiscal Year: 2001
    ..Do prior adaptations make the diaphragm more or less susceptible to exercise-induced muscle injury? ..
  43. RESPIRATORY SYSTEM MECHANICS
    ALADIN BORIEK; Fiscal Year: 2002
    DESCRIPTION: The respiratory muscles are a major determinant of thoracic cavity shape and thus the distribution of regional ventilation. Respiratory insufficiency is the usual cause of death in many primary neuromuscular disorders...
  44. Drug-Induced Motor Recovery After Spinal Cord Injury
    Kwaku Nantwi; Fiscal Year: 2005
    ..and subsequent pharmacologic activation of latent respiratory motor pathways to restore function to respiratory muscles paralyzed by spinal cord injury...
  45. RESPIRATORY CONSEQUENCES OF OPIATES
    TEODORO SANTIAGO; Fiscal Year: 1992
    ..suggested that opioid elaboration in this setting relieves dyspnea and possibly postpones fatigue of the respiratory muscles. In the proposed studies, the mechanisms by which opiates and opioids modulate breathing during conditions ..
  46. NEURAL CONTROL RESPIRATORY MUSCLES DURING EXPIRATION
    Erik van Lunteren; Fiscal Year: 1991
    Active control of expiratory airflow by the respiratory muscles influences gas exchange, the degree of emptying of the lungs, and the work of breathing; may help optimize inspiratory muscle function; and is important during coughing and ..
  47. FREE RADICALS AND RESPIRATORY LOADING
    GERALD SUPINSKI; Fiscal Year: 1999
    ..Objective I experiments will examine the respiratory muscles following various regimens of chronic loading for evidence of free radical elaboration, lipid peroxidation ..
  48. Does sleep apnea exacerbate respiratory muscle dysfunction in muscular dystrophy?
    GASPAR FARKAS; Fiscal Year: 2009
    ..Dystrophin-deficient muscles are more susceptible than normal to a variety of stresses. The respiratory muscles are critical for survival and their failure is a leading cause of death in DMD...
  49. NEURAL INHIBITION AND REM SLEEP DISORDERED BREATHING
    Joan Hendricks; Fiscal Year: 1992
    ..Lesions in this area can abolish muscle inhibition and, we propose, relieve SDB by increasing the drive for respiratory muscles during REMS...
  50. RESPIRATORY MUSCLE FUNCTION IN HEALTH AND DISEASE
    Steven Kelsen; Fiscal Year: 1991
    Chronic obstructuve lung disease (COPD) alters the length and alignment of the respiratory muscles and causes generalized body wasting...
  51. NEUROMUSCULAR TARGETS OF BOTULINUM TOXIN
    JULIE COFFIELD; Fiscal Year: 2006
    ....
  52. NEURAL MECHANISMS OF LARYNGEAL CONTROL
    Charles Larson; Fiscal Year: 1993
    ....
  53. RESPIRATORY MUSCLES DURING DEVELOPMENT
    Gary Sieck; Fiscal Year: 2001
    ..With shortening contractions, the increase in actomyosin ATPase activity varies across fiber types, reflecting differences in the impact of active shortening on alpha-fs and g-app. ..
  54. Neural control of noninvasive ventilation in the preterm
    Michael Dunn; Fiscal Year: 2004
    ..abstract_text> ..
  55. RESPIRATORY MUSCLE ENERGETICS DURING EXERCISE
    Murli Manohar; Fiscal Year: 1992
    ..exercise have focussed our attention on the question "whether the metabolic O2 requirements of the respiratory muscles are sufficient to limit VO2max and exercise capacity of the locomotor muscles?" As yet only limited ..
  56. AUTONOMIC REGULATION OF RESPIRATORY MUSCLE & SECRETION
    Alan Leff; Fiscal Year: 1992
    ..Data derived from these studies will suggest approaches for therapeutic interventions in asthma and obstructive airways disease in humans...
  57. RESPIRATORY AFFERENT PROJECTIONS TO THE CEREBRAL CORTEX
    Paul Davenport; Fiscal Year: 1991
    ..Determination of the projection and processing of respiratory muscle afferents by higher brain centers provides a basis for continued study of the mechanism of respiratory sensation...
  58. Identification of Botulinum Toxin Membrane Targets
    JULIE COFFIELD; Fiscal Year: 2005
    ....
  59. DIAPHRAGM ADAPTATIONS TO RESPIRATORY TRAINING
    David Prezant; Fiscal Year: 1992
    ....
  60. MOLECULAR PHYSIOLOGY OF RESPIRATORY MUSCLES
    Jeffrey Boone Miller; Fiscal Year: 2010
    ..Lay summary: Our work will evaluate a therapeutic strategy for specific neuromuscular diseases. These diseases are highly debilitating and currently have poor treatment options. ..
  61. DEVELOPMENTAL CONTROL OF THE DIAPHRAGM AND UPPER AIRWAYS
    William Cameron; Fiscal Year: 2003
    ....
  62. DYSRHYTHMIAS OF THE RESPIRATORY OSCILLATOR
    David Paydarfar; Fiscal Year: 2002
    ..abstract): Breathing is controlled by a central neural oscillator that produces rhythmic output to the respiratory muscles. Pathological disturbances in rhythm (dysrhythmias) are commonly observed in clinical practice...
  63. Respiratory Function and Illness in Spinal Cord Injury
    Eric Garshick; Fiscal Year: 2006
    ..abstract_text> ..
  64. SCOR IN CARDIOPULMONARY DISORDERS DURING SLEEP
    Jerome Dempsey; Fiscal Year: 1992
    ..to patients with neuromuscular weakness and chronic lung disease as a means of intermittently "resting" respiratory muscles. Finally, our single largest undertaking brings an epidemiologic focus to the problem of cardiopulmonary ..