skeletal muscle

Summary

Summary: Striated muscles having fibers connected at either or both extremities with the bony framework of the body. These are found in appendicular and axial muscles. (From Stedman, 25th ed)

Top Publications

  1. pmc MicroRNA-206: the skeletal muscle-specific myomiR
    John J McCarthy
    Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Biochim Biophys Acta 1779:682-91. 2008
  2. ncbi Cellular and molecular regulation of muscle regeneration
    Sophie B P Chargé
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Physiol Rev 84:209-38. 2004
  3. ncbi Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
    A C McPherron
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 387:83-90. 1997
  4. ncbi Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
    S C Bodine
    Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road, Tarrytown, New York 10591 6707, USA
    Nat Cell Biol 3:1014-9. 2001
  5. pmc Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture
    P M Gilbert
    Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 329:1078-81. 2010
  6. ncbi PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    Vamsi K Mootha
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Nat Genet 34:267-73. 2003
  7. pmc Asymmetric self-renewal and commitment of satellite stem cells in muscle
    Shihuan Kuang
    The Sprott Center for Stem Cell Research, Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
    Cell 129:999-1010. 2007
  8. ncbi Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
    Stewart H Lecker
    Renal Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    FASEB J 18:39-51. 2004
  9. pmc Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming
    Yi Cao
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 18:662-74. 2010
  10. ncbi FoxO3 controls autophagy in skeletal muscle in vivo
    Cristina Mammucari
    Venetian Institute of Molecular Medicine, 35129 Padova, Italy
    Cell Metab 6:458-71. 2007

Detail Information

Publications315 found, 100 shown here

  1. pmc MicroRNA-206: the skeletal muscle-specific myomiR
    John J McCarthy
    Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Biochim Biophys Acta 1779:682-91. 2008
    ..One of these myomiRs (myo=muscle+miR=miRNA), miR-206, is unique in that it is only expressed in skeletal muscle. The purpose of this review is to discuss what is currently known about miR-206 and its function in ..
  2. ncbi Cellular and molecular regulation of muscle regeneration
    Sophie B P Chargé
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Physiol Rev 84:209-38. 2004
    Under normal circumstances, mammalian adult skeletal muscle is a stable tissue with very little turnover of nuclei...
  3. ncbi Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
    A C McPherron
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 387:83-90. 1997
    ..member, growth/differentiation factor-8 (GDF-8), which is expressed specifically in developing and adult skeletal muscle. During early stages of embryogenesis, GDF-8 expression is restricted to the myotome compartment of ..
  4. ncbi Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
    S C Bodine
    Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road, Tarrytown, New York 10591 6707, USA
    Nat Cell Biol 3:1014-9. 2001
    ..rapamycin) and calcineurin/NFAT (nuclear factor of activated T cells), were investigated in several models of skeletal muscle hypertrophy and atrophy in vivo...
  5. pmc Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture
    P M Gilbert
    Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 329:1078-81. 2010
    ..Our studies provide novel evidence that by recapitulating physiological tissue rigidity, propagation of adult muscle stem cells is possible, enabling future cell-based therapies for muscle-wasting diseases...
  6. ncbi PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    Vamsi K Mootha
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Nat Genet 34:267-73. 2003
    ..Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments...
  7. pmc Asymmetric self-renewal and commitment of satellite stem cells in muscle
    Shihuan Kuang
    The Sprott Center for Stem Cell Research, Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
    Cell 129:999-1010. 2007
    Satellite cells play a central role in mediating the growth and regeneration of skeletal muscle. However, whether satellite cells are stem cells, committed progenitors, or dedifferentiated myoblasts has remained unclear...
  8. ncbi Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
    Stewart H Lecker
    Renal Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    FASEB J 18:39-51. 2004
    b>Skeletal muscle atrophy is a debilitating response to starvation and many systemic diseases including diabetes, cancer, and renal failure...
  9. pmc Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming
    Yi Cao
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 18:662-74. 2010
    Recent studies have demonstrated that MyoD initiates a feed-forward regulation of skeletal muscle gene expression, predicting that MyoD binds directly to many genes expressed during differentiation...
  10. ncbi FoxO3 controls autophagy in skeletal muscle in vivo
    Cristina Mammucari
    Venetian Institute of Molecular Medicine, 35129 Padova, Italy
    Cell Metab 6:458-71. 2007
    ..which plays a critical role in muscle atrophy, is necessary and sufficient for the induction of autophagy in skeletal muscle in vivo...
  11. pmc AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    Sibylle Jäger
    Dana Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:12017-22. 2007
    Activation of AMP-activated kinase (AMPK) in skeletal muscle increases glucose uptake, fatty acid oxidation, and mitochondrial biogenesis by increasing gene expression in these pathways...
  12. ncbi IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
    Dongsheng Cai
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Cell 119:285-98. 2004
    ....
  13. ncbi Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
    C Rommel
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591-6707, USA
    Nat Cell Biol 3:1009-13. 2001
    b>Skeletal muscle is composed of multinucleated fibres, formed after the differentiation and fusion of myoblast precursors. Skeletal muscle atrophy and hypertrophy refer to changes in the diameter of these pre-existing muscle fibres...
  14. pmc The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina Chapel Hill, North Carolina 27599, USA
    Nat Genet 38:228-33. 2006
    ..miR-1 and miR-133 have distinct roles in modulating skeletal muscle proliferation and differentiation in cultured myoblasts in vitro and in Xenopus laevis embryos in vivo...
  15. ncbi Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
    H Cho
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 292:1728-31. 2001
    ..are impaired in the ability of insulin to lower blood glucose because of defects in the action of the hormone on liver and skeletal muscle. These data establish Akt2 as an essential gene in the maintenance of normal glucose homeostasis.
  16. ncbi Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche
    Charlotte A Collins
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Cell 122:289-301. 2005
    ..Thus, within a normally stable tissue, the satellite cell exhibits archetypal stem cell properties and is competent to form the basal origin of adult muscle regeneration...
  17. ncbi Identification of ubiquitin ligases required for skeletal muscle atrophy
    S C Bodine
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
    Science 294:1704-8. 2001
    b>Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling...
  18. pmc Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
    Charlotte Bonnard
    INSERM, U870, IFR62, Oullins, France
    J Clin Invest 118:789-800. 2008
    Mitochondrial dysfunction in skeletal muscle has been implicated in the development of type 2 diabetes. However, whether these changes are a cause or a consequence of insulin resistance is not clear...
  19. pmc Regulation of myostatin activity and muscle growth
    S J Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:9306-11. 2001
    Myostatin is a transforming growth factor-beta family member that acts as a negative regulator of skeletal muscle mass...
  20. ncbi Notch-mediated restoration of regenerative potential to aged muscle
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Science 302:1575-7. 2003
    ..Thus, Notch signaling is a key determinant of muscle regenerative potential that declines with age...
  21. pmc Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 141:280-9. 2010
    ..Here we examine the functions of mitochondrial fusion in differentiated skeletal muscle through conditional deletion of the mitofusins Mfn1 and Mfn2, mitochondrial GTPases essential for fusion...
  22. ncbi Direct isolation of satellite cells for skeletal muscle regeneration
    Didier Montarras
    CNRS Unité de Recherche Associée 2578, Department of Developmental Biology, INSERM, Pasteur Institute, 75724 Paris Cedex 15, France
    Science 309:2064-7. 2005
    ..Such cells, grafted into muscles of mdx nu/nu mice, contributed both to fiber repair and to the muscle satellite cell compartment. Expansion of these cells in culture before engraftment reduced their regenerative capacity...
  23. pmc Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells
    J R Beauchamp
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, W12 ONN United Kingdom
    J Cell Biol 151:1221-34. 2000
    b>Skeletal muscle is one of a several adult post-mitotic tissues that retain the capacity to regenerate. This relies on a population of quiescent precursors, termed satellite cells...
  24. ncbi A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
    Frederic Relaix
    C N R S URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Nature 435:948-53. 2005
    ..demonstrate that they constitute resident muscle progenitor cells that subsequently become myogenic and form skeletal muscle. Late in fetal development, these cells adopt a satellite cell position characteristic of progenitor cells in ..
  25. ncbi Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy
    J Liu
    Day Neuromuscular Research Laboratory, Charlestown, Massachusetts 02129, USA
    Nat Genet 20:31-6. 1998
    ..Five skeletal muscle expressed sequence tags (ESTs) map in this region...
  26. ncbi A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
    Alex Clop
    Unit of Animal Genomics, Department of Animal Production, Faculty of Veterinary Medicine and Centre for Biomedical Integrative Genoproteomics, University of Liège B43, 20 Boulevard de Colonster, 4000 Liege, Belgium
    Nat Genet 38:813-8. 2006
    ..in the 3' UTR that creates a target site for mir1 and mir206, microRNAs (miRNAs) that are highly expressed in skeletal muscle. This causes translational inhibition of the myostatin gene and hence contributes to the muscular hypertrophy ..
  27. ncbi Myostatin mutation associated with gross muscle hypertrophy in a child
    Markus Schuelke
    Department of Neuropediatrics, Charite, University Medical Center Berlin, Berlin, Germany
    N Engl J Med 350:2682-8. 2004
  28. ncbi A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    J C Bruning
    Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell 2:559-69. 1998
    b>Skeletal muscle insulin resistance is among the earliest detectable defects in humans with type 2 diabetes mellitus...
  29. ncbi Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    Samar I Itani
    Diabetes Unit, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Diabetes 51:2005-11. 2002
    ..Whether acute FFA-induced insulin resistance in human skeletal muscle is caused by the activation of these specific PKC isoforms and the IKK-beta/IkappaB/NFkappaB pathway remains ..
  30. ncbi Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
    Ian Janssen
    School of Physical and Health Education, Queen s University, Kingston, Ontario, Canada
    J Am Geriatr Soc 50:889-96. 2002
    ..To establish the prevalence of sarcopenia in older Americans and to test the hypothesis that sarcopenia is related to functional impairment and physical disability in older persons...
  31. doi Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy
    Antonio L Serrano
    Program on Differentiation and Cancer, Center for Genomic Regulation CRG and Center for Neurodegenerative Diseases CIBERNED, Pompeu Fabra University, Barcelona, Spain
    Cell Metab 7:33-44. 2008
    ..These findings unveil a role for IL-6 in hypertrophic muscle growth and provide mechanistic evidence for the contribution of satellite cells to this process...
  32. ncbi Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:30014-21. 2007
    ..receptor gamma coactivator 1alpha (PGC-1alpha) is a key integrator of neuromuscular activity in skeletal muscle. Ectopic expression of PGC-1alpha in muscle results in increased mitochondrial number and function as well as ..
  33. pmc PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16260-5. 2006
    ..Thus, the high levels of PGC-1alpha in dark and exercising muscles can explain their resistance to atrophy, and the rapid fall in PGC-1alpha during atrophy should enhance the FoxO-dependent loss of muscle mass...
  34. ncbi Invited review: Aging and sarcopenia
    Timothy J Doherty
    RM 066, St Mary s Hospital, St Joseph s Health Centre, 21 Grosvenor St, London, ON, Canada N6A 1Y6
    J Appl Physiol (1985) 95:1717-27. 2003
    ..The term sarcopenia is now commonly used to describe the loss of skeletal muscle mass and strength that occurs in concert with biological aging...
  35. ncbi Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 418:797-801. 2002
    The biochemical basis for the regulation of fibre-type determination in skeletal muscle is not well understood...
  36. pmc The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation
    Giuseppina Caretti
    Muscle Gene Expression Group, Laboratory of Muscle Biology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 18:2627-38. 2004
    ....
  37. pmc Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice
    Margaret Wong
    Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, 558 Ross Building, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Hum Mol Genet 19:2284-302. 2010
    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs) that causes skeletal muscle paralysis. Familial forms of ALS are linked to mutations in the superoxide dismutase-1 (SOD1) gene...
  38. ncbi Pax7 is required for the specification of myogenic satellite cells
    P Seale
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Cell 102:777-86. 2000
    ..Cell culture and electron microscopic analysis revealed a complete absence of satellite cells in Pax7(-/-) skeletal muscle. Surprisingly, fluorescence-activated cell sorting analysis indicated that the proportion of muscle-derived ..
  39. pmc MIR-206 regulates connexin43 expression during skeletal muscle development
    Curtis Anderson
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miller School of Medicine, Gautier Building 303, 1011 NW 15 Street, Miami, FL 33136, USA
    Nucleic Acids Res 34:5863-71. 2006
    ..that miR-1 is involved in myogenesis, in this work we show that miR-206 is also upregulated during perinatal skeletal muscle development in mice in vivo and that both miR-1 and miR-206 downregulate Cx43 expression during myoblast ..
  40. ncbi Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
    A Musaro
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts, USA
    Nat Genet 27:195-200. 2001
    ..transgene encoding a locally acting isoform of insulin-like growth factor-1 that is expressed in skeletal muscle (mIgf-1)...
  41. pmc Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells
    Francesco Saverio Tedesco
    Division of Regenerative Medicine, San Raffaele Scientific Institute, 58 Via Olgettina, Milan, Italy
    J Clin Invest 120:11-9. 2010
    b>Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers...
  42. pmc Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    Xiao ding Peng
    Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 17:1352-65. 2003
    ..These mice display impaired skin development because of a proliferation defect, severe skeletal muscle atrophy because of a marked decrease in individual muscle cell size, and impaired bone development...
  43. doi Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle
    Akiyoshi Uezumi
    Division for Therapies against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, 1 98 Dengakugakubo, Kutsukake, Toyoake, Aichi 470 1192, Japan
    Nat Cell Biol 12:143-52. 2010
    Ectopic fat deposition in skeletal muscle is closely associated with several disorders, however, the origin of these adipocytes is not clear, nor is the mechanism of their formation...
  44. pmc AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    Haihong Zong
    Howard Hughes Medical Institute and the Departments of Internal Medicine, Cell Biology, and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:15983-7. 2002
    ..These data demonstrate that by sensing the energy status of the muscle cell, AMPK is a critical regulator involved in initiating mitochondrial biogenesis...
  45. ncbi Defective membrane repair in dysferlin-deficient muscular dystrophy
    Dimple Bansal
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Nature 423:168-72. 2003
    ..dystrophy includes a diverse group of inherited muscle diseases characterized by wasting and weakness of skeletal muscle. Mutations in dysferlin are linked to two clinically distinct muscle diseases, limb-girdle muscular dystrophy ..
  46. pmc Role of AMP-activated protein kinase in mechanism of metformin action
    G Zhou
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Clin Invest 108:1167-74. 2001
    ..Activation of AMPK provides a unified explanation for the pleiotropic beneficial effects of this drug; these results also suggest that alternative means of modulating AMPK should be useful for the treatment of metabolic disorders...
  47. pmc Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells
    Fabien Le Grand
    Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Regenerative Medicine Program, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
    Cell Stem Cell 4:535-47. 2009
    Satellite cells in skeletal muscle are a heterogeneous population of stem cells and committed progenitors...
  48. doi Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
    C Florian Bentzinger
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Cell Metab 8:411-24. 2008
    ..Finally, we show that activation of PKB/Akt does not require mTORC2. Together, these results demonstrate that muscle mTORC1 has an unexpected role in the regulation of the metabolic properties and that its function is essential for life...
  49. ncbi Costameres: the Achilles' heel of Herculean muscle
    James M Ervasti
    Department of Physiology, University of Wisconsin Medical School, Madison 53706, USA
    J Biol Chem 278:13591-4. 2003
  50. ncbi Regulation of contraction in striated muscle
    A M Gordon
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195 7290, USA
    Physiol Rev 80:853-924. 2000
    ..In skeletal muscle, strong binding of cycling cross bridges promotes additional Tm movement...
  51. ncbi Dystrophin expression in the mdx mouse restored by stem cell transplantation
    E Gussoni
    Division of Genetics, Children s Hospital, Boston, Massachusetts 02115, USA
    Nature 401:390-4. 1999
    ..Our studies also suggest that the inherent developmental potential of stem cells isolated from diverse tissues or organs may be more similar than previously anticipated...
  52. pmc Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells
    Aster H Juan
    Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 36:61-74. 2009
    ..of developmental regulators in embryonic stem (ES) cells and in committed cell lineages, including skeletal muscle cells (SMC)...
  53. ncbi Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity
    Daniel Bach
    Parc Cientific de Barcelona, Facultat de Biologia, Universitat de Barcelona, Barcelona 08028, Spain
    J Biol Chem 278:17190-7. 2003
    ....
  54. pmc Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
    Zachary Gerhart-Hines
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    EMBO J 26:1913-23. 2007
    ..Here, we show that fasting induced PGC-1alpha deacetylation in skeletal muscle and that SIRT1 deacetylation of PGC-1alpha is required for activation of mitochondrial fatty acid oxidation ..
  55. pmc Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:8466-71. 2003
    ..In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, glycogen synthesis, and accumulation of ..
  56. ncbi A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle
    L Grobet
    Department of Genetics, Faculty of Veterinary Medicine, University of Liege, Belgium
    Nat Genet 17:71-4. 1997
    ..We report an 11-bp deletion in the coding sequence for the bioactive carboxy-terminal domain of the protein causing the muscular hypertrophy observed in Belgian Blue cattle...
  57. ncbi Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
    Andrew S Brack
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 317:807-10. 2007
    The regenerative potential of skeletal muscle declines with age, and this impairment is associated with an increase in tissue fibrosis...
  58. doi Autophagy in skeletal muscle
    Marco Sandri
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    FEBS Lett 584:1411-6. 2010
    ..However, excessive protein degradation in the skeletal muscle is detrimental for the economy of the body and it can lead to death...
  59. pmc Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 75390 9148, USA
    Nature 408:106-11. 2000
    ....
  60. ncbi The skeletal muscle satellite cell: the stem cell that came in from the cold
    Peter S Zammit
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL England
    J Histochem Cytochem 54:1177-91. 2006
    ..This is a fast-moving and dynamic field, however, and in this review we discuss the evidence that we think puts this enigmatic cell firmly back at the center of adult myogenesis...
  61. ncbi Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation
    Peter Plomgaard
    Department of Infectious Diseases, Rigshopitalet University of Copenhagen, Denmark
    Diabetes 54:2939-45. 2005
    ..Here, we demonstrate that TNF-alpha infusion in healthy humans induces insulin resistance in skeletal muscle, without effect on endogenous glucose production, as estimated by a combined euglycemic insulin clamp and ..
  62. ncbi Inflammatory processes in muscle injury and repair
    James G Tidball
    Department of Physiological Science, 5833 Life Science Bldg, University of California, Los Angeles, CA 90095, USA
    Am J Physiol Regul Integr Comp Physiol 288:R345-53. 2005
    ..Recent investigations have begun to explore the relationship between inflammatory cell functions and skeletal muscle injury and repair by using genetically modified animal models, antibody depletions of specific inflammatory ..
  63. ncbi Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA
    Science 306:457-61. 2004
    ..Pharmacologic manipulation of this pathway may offer novel opportunities for treating these common diseases...
  64. pmc AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    Carles Canto
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Nature 458:1056-60. 2009
    ..Here we demonstrate that AMPK controls the expression of genes involved in energy metabolism in mouse skeletal muscle by acting in coordination with another metabolic sensor, the NAD+-dependent type III deacetylase SIRT1...
  65. pmc Double muscling in cattle due to mutations in the myostatin gene
    A C McPherron
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:12457-61. 1997
    ..beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass in mice...
  66. pmc Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 117:399-412. 2004
    b>Skeletal muscle atrophy is a debilitating response to fasting, disuse, cancer, and other systemic diseases...
  67. pmc microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7
    Jian Fu Chen
    McAllister Heart Institute, Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 190:867-79. 2010
    b>Skeletal muscle satellite cells are adult stem cells responsible for postnatal skeletal muscle growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite cell survival, self-renewal, and proliferation...
  68. pmc An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
    Ning Liu
    Departments of Molecular Biology and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 104:20844-9. 2007
    ..together with MyoD also regulates the miR-1-2/-133a-1 intragenic enhancer in the somite myotomes and in all skeletal muscle fibers during embryogenesis and adulthood...
  69. pmc Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo
    James G Tidball
    Department of Physiological Science, 5833 Life Science Building, University of California, Los Angeles, CA 90095, USA
    J Physiol 578:327-36. 2007
    ..These findings collectively show that macrophages play a significant role in muscle fibre membrane repair, regeneration and growth during increased muscle use after a period of atrophy...
  70. pmc Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration
    Kathleen Kelly Tanaka
    MCD Biology, University of Colorado, Boulder, CO 80309, USA
    Cell Stem Cell 4:217-25. 2009
    b>Skeletal muscle satellite cells, located between the basal lamina and plasma membrane of myofibers, are required for skeletal muscle regeneration...
  71. pmc Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles
    Massimiliano Cerletti
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA
    Cell 134:37-47. 2008
    Satellite cells reside beneath the basal lamina of skeletal muscle fibers and include cells that act as precursors for muscle growth and repair...
  72. ncbi Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
    A Zisman
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 6:924-8. 2000
    ..The specific genes involved are not yet known, but impaired glucose uptake in skeletal muscle is an early, genetically determined defect that is present in non-diabetic relatives of diabetic subjects...
  73. ncbi The kinase domain of titin controls muscle gene expression and protein turnover
    Stephan Lange
    Muscle Signalling and Development, Randall Division, King s College London, London SE1 1UL, UK
    Science 308:1599-603. 2005
    ..A human mutation in the titin protein kinase domain causes hereditary muscle disease by disrupting this pathway...
  74. ncbi The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 3:397-409. 2002
    ....
  75. ncbi Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells
    Arianna Dellavalle
    Stem Cell Research Institute, San Raffaele Scientific Institute, 58 Via Olgettina, 20132 Milan, Italy
    Nat Cell Biol 9:255-67. 2007
    Cells derived from blood vessels of human skeletal muscle can regenerate skeletal muscle, similarly to embryonic mesoangioblasts...
  76. pmc Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise
    Stephanie Eva Wohlgemuth
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL 32610, USA
    Exp Gerontol 45:138-48. 2010
    ..We conclude that mild CR attenuates the age-related impairment of autophagy in rodent skeletal muscle, which might be one of the mechanisms by which CR attenuates age-related cellular damage and cell death in ..
  77. ncbi Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control
    Yasutomi Kamei
    PRESTO, Japan Science and Technology Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Biol Chem 279:41114-23. 2004
    FOXO1, a member of the FOXO forkhead type transcription factors, is markedly up-regulated in skeletal muscle in energy-deprived states such as fasting and severe diabetes, but its functions in skeletal muscle have remained poorly ..
  78. ncbi Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation
    A Asakura
    Ottawa Health Research Institute, Ontario, Canada
    Differentiation 68:245-53. 2001
    ..represent a committed stem cell population that is responsible for the postnatal growth and regeneration of skeletal muscle. However, the observation that cultured myoblasts differentiate into osteocytes or adipocytes following ..
  79. pmc AMPK and PPARdelta agonists are exercise mimetics
    Vihang A Narkar
    Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037, USA
    Cell 134:405-15. 2008
    ..These results demonstrate that AMPK-PPARdelta pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise...
  80. ncbi Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
    Daniel Cuthbertson
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, Scotland
    FASEB J 19:422-4. 2005
    ..Countermeasures to maximize muscle maintenance should target these deficits...
  81. ncbi Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
    W W Winder
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol (1985) 88:2219-26. 2000
    ..chemical activation of AMPK will increase mitochondrial enzymes, GLUT-4, and hexokinase in different types of skeletal muscle of resting rats...
  82. pmc Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activity
    Lionel Bey
    Department of Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri Columbia, MO, USA
    J Physiol 551:673-82. 2003
    We have examined the regulation of lipoprotein lipase (LPL) activity in skeletal muscle during physical inactivity in comparison to low-intensity contractile activity of ambulatory controls...
  83. ncbi Induction of cachexia in mice by systemically administered myostatin
    Teresa A Zimmers
    Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 296:1486-8. 2002
    Mice and cattle with genetic deficiencies in myostatin exhibit dramatic increases in skeletal muscle mass, suggesting that myostatin normally suppresses muscle growth...
  84. ncbi Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    David E Kelley
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Diabetes 51:2944-50. 2002
    b>Skeletal muscle is strongly dependent on oxidative phosphorylation for energy production...
  85. doi Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia
    Simona Greco
    Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese, Milan, Italy
    FASEB J 23:3335-46. 2009
    The aim of this work was to identify micro-RNAs (miRNAs) involved in the pathological pathways activated in skeletal muscle damage and regeneration by both dystrophin absence and acute ischemia...
  86. ncbi The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation
    Irina Naguibneva
    UPR9079 CNRS Ligue Nationale Contre le Cancer, 7 rue Guy Moquet, 94801 Villejuif Cedex, France
    Nat Cell Biol 8:278-84. 2006
    Deciphering the mechanisms underlying skeletal muscle-cell differentiation in mammals is an important challenge. Cell differentiation involves complex pathways regulated at both transcriptional and post-transcriptional levels...
  87. doi Skeletal muscle is a primary target of SOD1G93A-mediated toxicity
    Gabriella Dobrowolny
    Institute Pasteur Cenci Bolognetti, Department of Histology and Medical Embryology, CE BEMM and IIM, Sapienza University of Rome, Via A Scarpa, 14 Rome 00161, Italy
    Cell Metab 8:425-36. 2008
    ..by the generation of a transgenic mouse model expressing a mutant SOD1 gene (SOD1(G93A)) selectively in skeletal muscle. Transgenic mice developed progressive muscle atrophy, associated with a significant reduction in muscle ..
  88. doi HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha
    Zoltan Arany
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 451:1008-12. 2008
    ..and oxygen, and PGC-1alpha powerfully regulates VEGF expression and angiogenesis in cultured muscle cells and skeletal muscle in vivo...
  89. ncbi Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia
    Fulvio Lauretani
    Geriatric Department, Italian National Insitute of Research and Care on Aging, Florence, Italy
    J Appl Physiol 95:1851-60. 2003
    ..The findings of the study lay the basis for a cost-effective, clinical marker of sarcopenia based on a measure of isometric handgrip strength. Our findings should be verified in a longitudinal study...
  90. pmc Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
    Ludovic Arnold
    Institut National de la Sante et de la Recherche Medicale, Unite 841, Institut Mondor de Recherche Biomedicale, Cell Interactions in the Neuromuscular System Team, Universite Paris 12 Val de Marne, Creteil, France
    J Exp Med 204:1057-69. 2007
    Macrophages (MPs) are important for skeletal muscle regeneration in vivo and may exert beneficial effects on myogenic cell growth through mitogenic and antiapoptotic activities in vitro...
  91. ncbi A population of myogenic stem cells that survives skeletal muscle aging
    Charlotte A Collins
    The Dubowitz Neuromuscular Unit, Department of Paediatrics, Imperial College London, Hammersmith Hospital, London, U K
    Stem Cells 25:885-94. 2007
    ..The satellite cell, resident beneath the basal lamina of skeletal muscle myofibers, is the principal myogenic stem cell...
  92. doi Fibre types in skeletal muscle: a personal account
    S Schiaffino
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Acta Physiol (Oxf) 199:451-63. 2010
    ....
  93. pmc Microrna-221 and microrna-222 modulate differentiation and maturation of skeletal muscle cells
    Beatrice Cardinali
    Istituto di Biologia Cellulare, Consiglio Nazionale delle Ricerche, Monterotondo, Italy
    PLoS ONE 4:e7607. 2009
    ..miRNAs have been shown to play crucial roles in muscle development and in regulation of muscle cell proliferation and differentiation...
  94. ncbi Stem and progenitor cells in skeletal muscle development, maintenance, and therapy
    Bruno Peault
    Stem Cell Research Center, Children s Hospital of Pittsburgh, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Mol Ther 15:867-77. 2007
    ..As an alternative to myoblast transplantation, stem cells such as mesoangioblasts and CD133+ progenitors administered through blood circulation have recently shown great potential to regenerate dystrophic muscle...
  95. ncbi Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors
    H E Young
    Division of Basic Medical Science, Mercer University School of Medicine, Macon, Georgia 31207, USA
    Anat Rec 264:51-62. 2001
    ..Stem cells were isolated from the connective tissues of dermis and skeletal muscle derived from fetal, mature, and geriatric humans...
  96. ncbi Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 8:1288-95. 2002
    ..activation of the 5'-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full-length Ad in the liver...
  97. ncbi Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy
    R S Savkur
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    Nat Genet 29:40-7. 2001
    ..People with DM1 have an unusual form of insulin resistance caused by a defect in skeletal muscle. Here we demonstrate that alternative splicing of the insulin receptor (IR) pre-mRNA is aberrantly regulated ..
  98. pmc MicroRNA transcriptome profiles during swine skeletal muscle development
    Tara G McDaneld
    USDA ARS Meat Animal Research Center, Clay Center, NE, USA
    BMC Genomics 10:77. 2009
    ..To evaluate the role of miR in skeletal muscle of swine, global microRNA abundance was measured at specific developmental stages including proliferating ..
  99. pmc The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 104:12587-94. 2007
    We examined the hypothesis that insulin resistance in skeletal muscle promotes the development of atherogenic dyslipidemia, associated with the metabolic syndrome, by altering the distribution pattern of postprandial energy storage...
  100. ncbi Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction
    G Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University Hospital, Philadelphia PA 19140, USA
    Eur J Clin Invest 32:14-23. 2002
    Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart, liver and pancreas. However, chronically elevated plasma FFA appear to have pathophysiological consequences...
  101. ncbi The anti-inflammatory effect of exercise
    Anne Marie W Petersen
    Dept of Infectious Diseases, Rigshospitalet, Section 7641, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    J Appl Physiol 98:1154-62. 2005
    ..IL-6 was introduced as the first myokine, defined as a cytokine that is produced and released by contracting skeletal muscle fibers, exerting its effects in other organs of the body...

Research Grants75

  1. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..at the hypothalamus;and it modulates peripheral metabolism through effects on adipose tissue, the liver, skeletal muscle and the endocrine pancreas...
  2. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..In addition, the PRDM16^'BAT expressed higher levels of skeletal muscle (Sl\/l)-specific genes (2) supporting the notion that SIVl and BAT may arise from a common lineage (3)...
  3. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..Research, primarily conducted in fat and skeletal muscle tissue, indicates that several Ser kinases, including ROK, may inhibit insulin metabolic signaling by ..
  4. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..of injury, there are significant decrease in whole body fat-free mass (FFM), particularly lower extremity skeletal muscle mass and subsequent increase in fat mass (FM)...
  5. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..breathing, and swallowing, depend on the rapid transfer of information between motor neurons and the skeletal muscle fibers they innervate that takes place at a specialized contact called the neuromuscular junction...
  6. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..may be driven by a decrease in INS-mediated vasorelaxation and glucose transport in cardiovascular (CV) and skeletal muscle tissue...
  7. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..and demonstrated that Txnip modulates mitochondrial fuel oxidation and insulin sensitivity in cardiac and skeletal muscle. Mitochondrial dysfunction and abnormal fuel metabolism are linked to the development of obesity, diabetes ..
  8. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..b>Skeletal muscle is also a prime target organ for gene therapy, since engineered myoblasts can be made to fuse with mature ..
  9. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..Defect in glycogen synthesis of the skeletal muscle is thought to be one of the major causes of insulin resistance...
  10. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..In skeletal muscle its patterns of interest cover multiple time scales: milliseconds -Ca2+ movements that determine contraction ..
  11. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..We will employ Lrat-/- and Rbp-/- mice and mice expressing lipoprotein lipase (LpL) solely in skeletal muscle (MCK-LpL0 mice) to investigate these relationships...
  12. Notch and Regulators of Notch Signaling Impact Both Glucose and Lipid Metabolism
    UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2013
    ..available insulin sensitizers are only partially effective at improving glucose disposal in skeletal muscle and suppressing glucose production in liver...
  13. Pathogenesis of the Metabolic Syndrome
    W Timothy Garvey; Fiscal Year: 2013
    ..Insulin resistance at the level of skeletal muscle is central to the underlying pathogenesis of all these disease manifestations...
  14. MR Monitoring of PTC124 Treatment in DMD
    KRISTA H VANDENBORNE; Fiscal Year: 2010
    ..study to determine the ability of MRI/MRS to monitor the short and long term effect of PTC124 treatment on skeletal muscle. Magnetic resonance measurements of muscle damage/inflammation, muscle contractile tissue and intramuscular ..
  15. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
    ..exclusively in adipose cells, but can be found in many, if not most, tissues and cells, including liver, skeletal muscle, cardiac muscle, enterocytes, and leukocytes, under certain physiological and pathophysiological conditions ..
  16. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..coupling, and calcium transport) will be evaluated in mitochondria isolated from several tissues (liver, skeletal muscle, heart, and adipose)...
  17. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..and tested several GC analogues that efficiently block inflammation by inhibiting NF-kB activity in skeletal muscle cells...
  18. Interactions of the RAAS and a Western Diet on Insulin Metabolic Actions
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..may be driven by a decrease in INS-mediated vasorelaxation and glucose transport in cardiovascular (CV) and skeletal muscle tissue...
  19. UNDERSTANDING VIBRATION INJURY
    Danny A Riley; Fiscal Year: 2013
    ..frequency, acceleration, amplitude and duration to structural damage of the innervation of skin, artery and skeletal muscle and the functional deficits related to loss of feeling and muscle weakness (nerve conduction velocity, von ..
  20. Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant Depression
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..is endogenous to all vertebrates, and is known to play a vital role in maintaining ATP supplies in brain and skeletal muscle. In preclinical animal models, creatine supplementation alters rodent depression-like behaviors in a gender-..
  21. Maternal nutrient restriction and nonhuman primate fetal skeletal muscle developm
    Min Du; Fiscal Year: 2010
    ..Underlying mechanisms remain undefined. RATIONALE: Sheep and rat studies indicate that FNR affects fetal skeletal muscle (SM) development with long-lasting effects on adult SM properties...
  22. Ca Signaling in Progression of Amyotrophic Lateral Sclerosis in Skeletal Muscle
    Jingsong Zhou; Fiscal Year: 2013
    ..ALS) is a progressive neuromuscular disorder involving degeneration of motor neurons and atrophy of skeletal muscle. Mutations in the superoxide dismutase (SOD1) gene are linked to most cases of inherited ALS, resulting in ..
  23. Vascular and Skeletal Muscle Function in Gulf War Veterans Illness
    Scott Kinlay; Fiscal Year: 2013
    ..Our Pilot study will assess three facets of vascular and skeletal muscle function in 25 cases with GWVI and 25 Veteran controls without GWVI...
  24. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..finding that T1AM is robustly transported into a variety of cell types, including cells derived from fat and skeletal muscle, and this transport is mechanism is highly selective for T1AM and occurs by a mechanism that does not involve ..
  25. Role of murine induced pluripotent stem cells on the correction of cardiac and sk
    Diego Fraidenraich; Fiscal Year: 2010
    ..In this application we would like to characterize the murine iPS cells in their role to rescue cardiac and skeletal muscle disease, exemplified by the Id knockout mice and the mdx mice...
  26. Secondary Muscle Pathology &Metabolic Dysregulation in Adult with Cerebral Palsy
    Mark Peterson; Fiscal Year: 2013
    ..3) To develop the technical and statistical skills to conduct specialized imaging for quantifying skeletal muscle and adipose tissue, serum and in vivo studies for markers of inflammation and insulin resistance, and ..
  27. Nutrition and Anabolic Interventions in Cancer Cachexia
    Melinda Sheffield-Moore; Fiscal Year: 2013
    Project Summary/Abstract Cancer cachexia severely depletes skeletal muscle mass leading to impairments in physical function and a diminished quality of life. In the clinical realm, malnutrition and cachexia are synonymous...
  28. Role of troponin T isoforms in nemaline myopathy
    Jian Ping Jin; Fiscal Year: 2012
    ..The ANM allele contains a nonsense mutation in the slow skeletal muscle troponin T (TnT) gene (TNNT1), which results in truncation of the TnT protein at amino acid 179...
  29. Effects of periodontitis on insulin target organs and glucose homeostasis
    Keiko Watanabe; Fiscal Year: 2013
    ..glucose levels in a narrow ideal range by balancing production of glucose by the liver and glucose uptake by skeletal muscle and adipose tissue...
  30. Novel pathways for fat burning that protects from high fat diet-induced metabolic
    Sihem Boudina; Fiscal Year: 2013
    ..Under this aim, we will first determine the contribution of white and brown adipose tissue, liver and skeletal muscle in enhancing whole body fat oxidation, then investigate whether the increase in whole body fat oxidation ..
  31. NPC1L1 and Metabolic Diseases
    Liqing Yu; Fiscal Year: 2013
    ..associated with increased expression of genes promoting energy expenditure in brown adipose tissue (BAT) and skeletal muscle. Thus, we hypothesize that NPC1L1 deficiency protects mice from DIO by increasing energy expenditure...
  32. MicroRNA Regulation of Macrophage Polarization in Muscle Regeneration
    Paula K Shireman; Fiscal Year: 2013
    ..b>Skeletal muscle, while being the tissue most vulnerable to ischemic damage in the extremities, also has an amazing potential ..
  33. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..lean mass unnecessarily increase risk of an adverse outcome in the setting of ongoing age-related declines in skeletal muscle and bone mass? Ideally, older adults using a prescribed dietary intervention combined with exercise would be ..
  34. Maternal Obesity affects AMP-Kinase in Muscle Cell Differentiation
    Min Du; Fiscal Year: 2013
    ..The underlying mechanisms remain poorly defined. RATIONALE: Skeletal muscle (SM) is a key tissue responsive to the oxidation of fatty acids and glucose, and its transition to insulin ..
  35. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..and tested several GC analogues that efficiently block inflammation by inhibiting NF-kB activity in skeletal muscle cells...
  36. Activity Dependent Signaling in Adult Skeletal Muscle Fiber Plasticity
    Martin F Schneider; Fiscal Year: 2012
    Regular skeletal muscle activity, including endurance exercise, is a key determinant of overall well being, and is crucial for countering the metabolic syndrome of obesity, insulin resistance and hypertension...
  37. Growth hormone and adult physiology
    Rhonda D Kineman; Fiscal Year: 2013
    ..sensitivity is due to global improvement in insulin actions or due to tissue-specific changes (liver, fat, skeletal muscle) 3) determine if AOiGHD will influence whole body metabolism and weight changes in response to acute fasting/..
  38. Intravenous Protein Therapy for Myotonic Dystrophy Type 1
    Richard Weisbart; Fiscal Year: 2010
    ..The ENT2 nucleotide scavenger transporter is enriched in skeletal muscle and cancer cells and mediates the cell-penetrating ability of Fv3E10 and Fv3E10 conjugates (28)...
  39. Nuclear Receptor Coactivator Functions and Mechanisms
    Robert G Roeder; Fiscal Year: 2013
    ..I myofiber genes;increased insulin sensitivity/glucose tolerance and resistance to diet-induced obesity) in skeletal muscle-specific Med1 knockout mice...
  40. Endoplasmic Reticulum Chaperone as a Regulator of Obesity and Diabetes
    Amy S Lee; Fiscal Year: 2010
    ..In contrast, glucose metabolism was not altered in skeletal muscle and no chaperone upregulation was observed...
  41. Effect of exposure to organochlorine compounds on the development of obesity and
    GEORGE E HOWELL; Fiscal Year: 2011
    ..The effect of exposure to OC compounds on insulin signaling in the skeletal muscle has not been delineated...
  42. RYGB Improves Metabolism by Interrupting the Gastric Adipose Tissue Axis
    Naji N Abumrad; Fiscal Year: 2013
    ..complimentary and comprehensive approaches: (i) In vivo studies to determine insulin sensitivity in liver and skeletal muscle and microdialysis of subcutaneous adipose tissue to assess tissue-specific oxidative stress, cytokine ..
  43. Molecular control of differential peptide transmitter exocytosis.
    COREY B SMITH; Fiscal Year: 2013
    ..generalized analgesia (enkephalin), increased cardiac output (elevated catecholamines), blood flow to skeletal muscle (atrial natriuretic factor, Neuropeptide Y) and blood glucose (pancreastatin)...
  44. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
    ..insulin, a peptide hormone that promotes the uptake and storage of carbohydrates and other nutrients in skeletal muscle while simultaneously repressing glucose efflux from the liver...
  45. PERIPHERAL AND CENTRAL INTERACTIONS IN ENERGY BALANCE
    Barbara B Kahn; Fiscal Year: 2010
    ..included the neural pathways activated by leptin and the cellular pathways engaged by leptin in the CMS and skeletal muscle. We also examined the effects of manipulation of leptin receptors in specific neuronal cell groups on energy ..
  46. In vitro Type Two Diabetes Mellitus Tissue Model to Investigate Insulin Resistanc
    KELLY ANNE BURKE; Fiscal Year: 2013
    ..lipolysis in insulin resistant adipose tissue can directly contribute to insulin resistance in liver and skeletal muscle through secretion of free fatty acids (FFAs) that activate pathways known to disrupt insulin signaling...
  47. Pbx Homeodomain Proteins in Skeletal Muscle Differentiation
    LISA A MAVES; Fiscal Year: 2011
    PROJECT SUMMARY The differentiation of muscle precursor cells into contractile skeletal muscle fibers is necessary for normal muscle development and regeneration and, when defective, leads to musculoskeletal diseases such as muscular ..
  48. Nuclear Control of Mitochondrial Gene Expression
    Gerald Shadel; Fiscal Year: 2013
    ..disrupt a multitude of cellular processes that can cause human disease pathology, ranging from heart, skeletal muscle and nerve dysfunction to diabetes, blindness, and deafness...
  49. The Impact of Heat Shock Protein Expression on Inflammation and Insulin Action
    Andrea L Hevener; Fiscal Year: 2013
    ..is a key metabolic abnormality of type 2 diabetes and is characterized by diminished insulin action in skeletal muscle, liver, and adipose tissue...
  50. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012
    ..and published literature, our working hypothesis is that HHcy impairs coordination of blood flow control in skeletal muscle by reducing cell-cell communication through gap junction and that this impairment can be reversed by exercise ..
  51. Dysfunctional PGC-1alpha expression in skeletal muscle during diabetes
    S Russ Price; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Skeletal muscle atrophy is a frequent co-morbidity of diabetes mellitus (DM) and other chronic diseases that causes fatigue and weakness...
  52. SIRT1 as a regulator of health and lifespan of mammals
    David A Sinclair; Fiscal Year: 2013
    ..proposal will investigate the mechanisms by which SIRT1 maintains genome synchrony and ETC stoichiometry in skeletal muscle, independent of the canonical PGC- 1[unreadable]/[unreadable] pathway...
  53. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ..Specific Aim 1. To evaluate the effect of uremia on GH mediated signal transduction in human skeletal muscle. Animal studies indicate that muscle wasting may be due in part to impaired GH mediated signal transduction...
  54. Experimental engineering of ovarian grafting to promote angiogenesis for fertilit
    GLENN LEWIS SCHATTMAN; Fiscal Year: 2010
    ..the role of candidate factors, notably VEGF and PDGF, involved in revascularizing mouse ovaries grafted into skeletal muscle and human ovarian xenografts in NOD-scid mice as a translational model...
  55. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2013
    ..cells, blood platelets, sweat and salivary glands, dentition, vascular smooth muscle, endothelial cells, and skeletal muscle. In the immune system, STIM1 and Orai1 mediate antigen-induced Ca2+ signaling, motility inhibition at the ..
  56. Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth
    Eugene D Albrecht; Fiscal Year: 2013
    ..e. skeletal muscle, of the fetus leadin to insulin sensitivity/glucose homeostasis after birth...
  57. Skeletal Muscle Mitochondrial Adaptations to a Two-Year Caloric Restiction
    STEVEN RICHARD SMITH; Fiscal Year: 2012
    ..with measures of mitochondrial enzyme content and mitochondrial ROS production assays performed on fresh skeletal muscle biopsies...
  58. Role of Selectins in Burns and Inhalation Injury
    Daniel Traber; Fiscal Year: 2009
    ..the activation of blood PMNs, PARP and NF-kappaB and limit tissue damage seen in the lung, ileum, pancreas, skeletal muscle and liver after burn and inhalation injury...
  59. Targeted investigation of tissue specific oxidative stress in the etiology of ALS
    Holly Van Remmen; Fiscal Year: 2013
    ..Through targeted expression of Cre recombinase to specific tissues (e.g., motor neurons, skeletal muscle, microglia and astrocytes) in the Gpx4flfl conditional knockout ALS mutant mice, we will generate tissue-..
  60. Noncoding RNA targets of the spinal muscular atrophy protein
    Livio Pellizzoni; Fiscal Year: 2010
    SMA is an autosomal recessive disorder characterized by degeneration of motor neurons in the spinal cord and skeletal muscle atrophy...
  61. Imaging Strategies to Measure Brown Fat and Its Activity
    C Ronald Kahn; Fiscal Year: 2010
    ..BAT), which is important for both basal and inducible energy expenditure directly via thermogenesis, and skeletal muscle, which generates heat through shivering...
  62. Planning a Multicenter Trial of PDE5A Inhibition for Duchenne Muscular Dystrophy
    Ronald G Victor; Fiscal Year: 2012
    ..of sarcolemmal nNOSm renders the diseased muscle fibers susceptible to functional ischemia and implicated skeletal muscle-derived nitric oxide (NO) as a novel therapeutic target for this refractory disease...
  63. Myogenic Potential of Extraocular Muscle Satellite Cells
    Linda K McLoon; Fiscal Year: 2010
    ..The reason for this sparing in DMD is unknown. Unlike limb skeletal muscle, normal adult EOM retain a population of activated satellite cells, the regenerative cell in adult skeletal ..
  64. FUNCTIONAL AND MOLECULAR STUDY OF HUMAN MASSETER FIBERS
    James Sciote; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Applicant's Abstract): Mammalian skeletal muscle fibers have been traditionally classified into specific types by characterization of their myofibrillar ATPase and metabolic histochemistry and more recently ..
  65. High Content Screening for Muscular Dystrophy
    Herman Vandenburgh; Fiscal Year: 2007
    ..to be developed in this Phase 1 SBIR project for Duchene muscular dystrophy (DMD) is based upon an in vitro skeletal muscle tissue force measurement technique for high content screening (HCS) of compounds to attenuate muscle weakness...
  66. Noninvasive assessment of skeletal muscle integrity and function with statin use
    Jill Slade; Fiscal Year: 2009
    ..g. lowering heart disease risk, vascular protection. As a result, statin use has increased in recent years. Skeletal muscle weakness and pain are occasional side effects of statin use (1-7%) and in rare cases severe muscle ..
  67. Aging, AMP Kinase and Skeletal Muscle Overload
    Scott Gordon; Fiscal Year: 2005
    Significant skeletal muscle atrophy results in a loss of functional independence and quality of life, and interventions such as resistance exercise training are not fully effective in restoring muscle mass in elderly individuals...
  68. Microvascular O2 Delivery: Impact of Erythrocyte-Released ATP
    Mary Ellsworth; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The regulation of oxygen (O2) supply to match demand in skeletal muscle is such a fundamental, physiological process that it is often assumed that the mechanisms responsible are well understood...
  69. SK CHANNELS IN HYPEREXCITABLE SKELETAL MUSCLE
    John Adelman; Fiscal Year: 2001
    DESCRIPTION: Skeletal muscle excitation is normally controlled by the influence of innervating nerve...
  70. A novel model for studying fetal skeletal muscle development
    Min Du; Fiscal Year: 2009
    ..b>Skeletal muscle is the main periphery tissue responsible for glucose and fatty acid utilization...
  71. Estrogen Effects on Atrophic Skeletal Muscle
    Marybeth Brown; Fiscal Year: 2009
    ..a lack of circulating E2 (subsequent to ovariectomy (OVX)) impairs recovery of laboratory-induced atrophic skeletal muscle. Failure to regrow atrophied muscles in OVX rats was associated with failure to initiate protein synthesis...
  72. Mammalian Target of Rapamycin and Insulin Resistance
    Thomas Reynolds; Fiscal Year: 2005
    ..Since skeletal muscle is the primary site for insulin-mediated glucose disposal, insulin resistance is thought to be due, in part, ..
  73. Aging and Endothelial Function of Muscle Arterioles
    JUDY DELP; Fiscal Year: 2002
    DESCRIPTION: (Verbatim from application) Skeletal muscle perfusion and endothelium-mediated vasodilation of the skeletal muscle resistance vasculature appear to diminish with advancing age; however, the precise mechanisms that underlie ..
  74. REHABILITATION OF MICRONEUROVASCULAR GRAFTS IN OLD RATS
    Lisa Larkin; Fiscal Year: 2000
    ..Her Ph.D. dissertation involved studies on the effect of aging on skeletal muscle glucose metabolism. Her primary research interest is the effect of aging on skeletal muscle metabolism...