muscles

Summary

Summary: Contractile tissue that produces movement in animals.

Top Publications

  1. ncbi Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    M E Gurney
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611
    Science 264:1772-5. 1994
  2. ncbi Energy metabolism in orchid bee flight muscles: carbohydrate fuels all
    Raul K Suarez
    Department of Ecology, Evolution and Marine Biology, University of California Santa Barbara, Santa Barbara, CA 93106 9610, USA
    J Exp Biol 208:3573-9. 2005
  3. ncbi Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    F Bladt
    Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
    Nature 376:768-71. 1995
  4. ncbi Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
    L Luo
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco 94143
    Genes Dev 8:1787-802. 1994
  5. pmc Direct control of paralysed muscles by cortical neurons
    Chet T Moritz
    Department of Physiology and Biophysics and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Nature 456:639-42. 2008
  6. pmc MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development
    Paul L Boutz
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 21:71-84. 2007
  7. pmc Restoration of grasp following paralysis through brain-controlled stimulation of muscles
    C Ethier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nature 485:368-71. 2012
  8. pmc FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 143:813-25. 2010
  9. doi Systematic genetic analysis of muscle morphogenesis and function in Drosophila
    Frank Schnorrer
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nature 464:287-91. 2010
  10. ncbi Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion
    G J Bashaw
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 97:917-26. 1999

Detail Information

Publications403 found, 100 shown here

  1. ncbi Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    M E Gurney
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611
    Science 264:1772-5. 1994
    ..The results show that dominant, gain-of-function mutations in SOD contribute to the pathogenesis of familial ALS...
  2. ncbi Energy metabolism in orchid bee flight muscles: carbohydrate fuels all
    Raul K Suarez
    Department of Ecology, Evolution and Marine Biology, University of California Santa Barbara, Santa Barbara, CA 93106 9610, USA
    J Exp Biol 208:3573-9. 2005
    ..A metabolic map, based on data reported herein and information from the literature, is presented. The evidence available supports the hypothesis that carbohydrate serves as the main fuel for flight in bees...
  3. ncbi Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    F Bladt
    Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
    Nature 376:768-71. 1995
    Limb muscles develop from cells that migrate from the somites. The signal that induces migration of myogenic precursor cells to the limb emanates from the mesenchyme of the limb bud...
  4. ncbi Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
    L Luo
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco 94143
    Genes Dev 8:1787-802. 1994
    ..Expressions of analogous mutant Dcdc42 proteins cause qualitatively distinct morphological defects, suggesting that similar GTPases in the same subfamily have unique roles in morphogenesis...
  5. pmc Direct control of paralysed muscles by cortical neurons
    Chet T Moritz
    Department of Physiology and Biophysics and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Nature 456:639-42. 2008
    ..Such signals could then control electrical stimulation of muscles, thereby restoring volitional movement to paralysed limbs...
  6. pmc MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development
    Paul L Boutz
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 21:71-84. 2007
    ..These results indicate that miR-133 directly down-regulates a key splicing factor during muscle development and establishes a role for microRNAs in the control of a developmentally dynamic splicing program...
  7. pmc Restoration of grasp following paralysis through brain-controlled stimulation of muscles
    C Ethier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nature 485:368-71. 2012
    ..the patient uses residual proximal limb movements to trigger pre-programmed stimulation that causes the paralysed muscles to contract, allowing use of one or two basic grasps...
  8. pmc FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 143:813-25. 2010
    ..Both FOXO and 4E-BP delay muscle functional decay and extend life span. Moreover, FOXO/4E-BP signaling in muscles decreases feeding behavior and the release of insulin from producing cells, which in turn delays the age-related ..
  9. doi Systematic genetic analysis of muscle morphogenesis and function in Drosophila
    Frank Schnorrer
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nature 464:287-91. 2010
    ..identify a role in muscle for 2,785 genes, many of which we assign to specific functions in the organization of muscles, myofibrils or sarcomeres...
  10. ncbi Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion
    G J Bashaw
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 97:917-26. 1999
    ..functions as a repulsive Netrin receptor; neurons expressing Fra-Robo avoid the Netrin-expressing midline and muscles. Robo-Fra (Robo's ectodomain and Fra's cytoplasmic domain) is an attractive Slit receptor; neurons and muscle ..
  11. ncbi Mutations affecting somite formation and patterning in the zebrafish, Danio rerio
    F J van Eeden
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:153-64. 1996
    ....
  12. ncbi Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
    J D Molkentin
    Department of Biochemistry and Molecular Biology University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cell 83:1125-36. 1995
    ....
  13. ncbi Drosophila MEF2, a transcription factor that is essential for myogenesis
    B A Bour
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Genes Dev 9:730-41. 1995
    ..These results indicate that MEF2 is required for later aspects of differentiation of the three major types of musculature, which include body wall muscles, gut musculature, and the heart, in the Drosophila embryo.
  14. ncbi Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions
    B A Stewart
    Department of Physiology, University of Toronto, Ontario, Canada
    J Comp Physiol A 175:179-91. 1994
    ..Thus, haemolymph-like solutions allow for prolonged, stable recording of synaptic transmission...
  15. ncbi Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg
    V Budnik
    Department of Biology, University of Massachusetts, Amherst 01003, USA
    Neuron 17:627-40. 1996
    ..By selectively targeting DLG protein to either muscles or motorneurons using Gal-4 enhancer trap lines, we were able to rescue substantially the reduced postsynaptic ..
  16. ncbi Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 433:760-4. 2005
    ..These results suggest that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age...
  17. doi Regulation of metabolism by dietary carbohydrates in two lines of rainbow trout divergently selected for muscle fat content
    Biju Sam Kamalam
    Institut National de la Recherche Agronomique INRA, Nutrition, Metabolism and Aquaculture Unit UR1067, F 64310 Saint Pée sur Nivelle, France
    J Exp Biol 215:2567-78. 2012
    ....
  18. doi Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera
    Lars Arendt-Nielsen
    Department of Health Sciences and Technology, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    J Pain 10:556-72. 2009
    ..different pain modalities (thermal, mechanical, electrical, and chemical) are applied to different tissues (skin, muscles, and viscera) and the responses are assessed by psychophysical methods (thresholds and stimulus-response ..
  19. ncbi Gene expression profiling in the early phases of DMD: a constant molecular signature characterizes DMD muscle from early postnatal life throughout disease progression
    Mario Pescatori
    Institute of Neurology, Catholic University, L go A Gemelli 8, 0018, Rome, Italy
    FASEB J 21:1210-26. 2007
    ....
  20. ncbi Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies
    Daniel E Michele
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242 1101, USA
    Nature 418:417-22. 2002
    ....
  21. pmc Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans
    P G Okkema
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210
    Genetics 135:385-404. 1993
    ..genes encode muscle-type specific myosin heavy chain isoforms: myo-1 and myo-2 are expressed in the pharyngeal muscles; unc-54 and myo-3 are expressed in body wall muscles...
  22. pmc An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans
    Barbara Meissner
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Genet 5:e1000537. 2009
    ..Many of the genes affecting sarcomere integrity have human homologs for which little or nothing is known...
  23. ncbi Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo
    G Ranganayakulu
    Department of Molecular Biology and Oncology, Hamon Center for Basic Cancer Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA
    Dev Biol 176:143-8. 1996
    The segregation of founder cells from the somatic mesoderm is a prerequisite for the formation of body wall muscles in the Drosophila embryo...
  24. ncbi C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane
    A M Labrousse
    Department of Biological Chemistry, University of California, Los Angeles School of Medicine 90095, USA
    Mol Cell 4:815-26. 1999
    ..These data indicate that wild-type DRP-1 contributes to the final stages of mitochondrial division by controlling scission of the mitochondrial outer membrane...
  25. pmc Muscle transcriptomic profiles in pigs with divergent phenotypes for fatness traits
    Angela Cánovas
    IRTA, Genetica i Millora Animal, 191 Av Alcalde Rovira Roure, 25198 Lleida, Spain
    BMC Genomics 11:372. 2010
    ....
  26. ncbi Targeted disruption of the acid alpha-glucosidase gene in mice causes an illness with critical features of both infantile and adult human glycogen storage disease type II
    N Raben
    Arthritis and Rheumatism Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:19086-92. 1998
    ..5 months of age) despite indistinguishable biochemical and pathological changes. The genetic background of the mouse strains appears to contribute to the differences among the three models...
  27. ncbi The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction
    Michael M Francis
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Neuron 46:581-94. 2005
    ..We hypothesize that CAM-1 contributes to the localization or stabilization of postsynaptic ACR-16 receptors and presynaptic release sites...
  28. pmc Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans
    Jeffrey N Stirman
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
    Nat Methods 8:153-8. 2011
    ..This technology enhances our ability to control, alter, observe and investigate how neurons, muscles and circuits ultimately produce behavior in animals using optogenetics.
  29. ncbi Development of the indirect flight muscles of Drosophila
    J Fernandes
    Molecular Biology Unit, Tata Institute of Fundamental Research, Colaba, Bombay, India
    Development 113:67-77. 1991
    We have followed the pupal development of the indirect flight muscles (IFMs) of Drosophila melanogaster. At the onset of metamorphosis larval muscles start to histolyze, with the exception of a specific set of thoracic muscles...
  30. pmc Epidermal egr-like zinc finger protein of Drosophila participates in myotube guidance
    G Frommer
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    EMBO J 15:1642-9. 1996
    ..are exclusively expressed in the epidermal muscle attachment cells and their ectodermal precursors, but not in muscles or muscle precursors...
  31. ncbi Cells with persistent twist expression are the embryonic precursors of adult muscles in Drosophila
    M Bate
    Department of Zoology, Cambridge, UK
    Development 113:79-89. 1991
    ..in the abdomen, they form ventral, lateral and dorsal clusters, which are the precursors of the adult abdominal muscles, while in the thorax, they form populations of cells in the imaginal discs that correspond to the adepithelial ..
  32. ncbi Muscle and neuronal nicotinic acetylcholine receptors. Structure, function and pathogenicity
    Dimitra Kalamida
    Department of Pharmacy, University of Patras, Rio Patras, Greece
    FEBS J 274:3799-845. 2007
    ..Here, we review some of the latest advances in our understanding of nAChRs and their involvement in physiology and pathology...
  33. ncbi Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila
    B Lilly
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Science 267:688-93. 1995
    ..These results demonstrate that different muscle cell types share a common myogenic differentiation program controlled by MEF2...
  34. pmc Gene expression in skin, muscle, and dorsal root ganglion after plantar incision in the rat
    Christina M Spofford
    Department of Anesthesia, University of Iowa, Iowa City, Iowa 52242, USA
    Anesthesiology 117:161-72. 2012
    ..To date, few studies have examined expression of other neurotrophin-related mediators that may contribute to the development and/or maintenance of incisional pain...
  35. ncbi MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos
    B W Draper
    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell 87:205-16. 1996
    After the first division of the C. elegans embryo, the posterior blastomere can produce numerous muscles while the anterior blastomere cannot...
  36. ncbi twist: a myogenic switch in Drosophila
    M K Baylies
    Department of Zoology, University of Cambridge, UK
    Science 272:1481-4. 1996
    ..Vertebrate homologs of twist may also participate in the subdivision of mesoderm...
  37. doi RNA-binding motif protein 24 regulates myogenin expression and promotes myogenic differentiation
    Donghao Jin
    Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Genes Cells 15:1158-67. 2010
    ..Rbm24 plays a crucial role in myogenic differentiation at least in part through a myogenin-dependent post-transcriptional regulatory pathway...
  38. pmc dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies
    Kushal Kr Banerjee
    Tata Institute of Fundamental Research Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, Mumbai, India
    Aging (Albany NY) 4:206-23. 2012
    ..This report delineates the functions of dSir2 in the fatbody and muscles with systemic consequences on fat metabolism and insulin signaling...
  39. ncbi Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo
    M Park
    Department of Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Mech Dev 75:117-26. 1998
    ..in development, individual mesodermal precursor cells are singled out to become the founder cells for specific muscles. The selection of muscle founder cells is thought to employ a Notch-mediated process of lateral inhibition, ..
  40. doi Carnosine: new concept for the function of an old molecule
    A A Boldyrev
    International Biotechnological Center of M V Lomonosov Moscow State University, 119991 Moscow, Russia
    Biochemistry (Mosc) 77:313-26. 2012
    ..The first attempts for application of carnosine in sport and medical practice are described...
  41. doi Bmp signaling at the tips of skeletal muscles regulates the number of fetal muscle progenitors and satellite cells during development
    Hui Wang
    CNRS, UMR7622, Universite Pierre et Marie Curie, 9 Quai St Bernard, Bat C, 6E, Case 24, 75252 Paris Cedex 05, France
    Dev Cell 18:643-54. 2010
    ..muscle progenitors and fibers, while blocking Bmp signaling reduces their numbers, ultimately leading to small muscles. The Bmp effect that we observed during fetal myogenesis is diametrically opposed to that previously observed ..
  42. pmc Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans
    Alexander Gottschalk
    Institute for Biochemistry, Goethe University, Frankfurt, Germany
    EMBO J 24:2566-78. 2005
    Nicotinic acetylcholine receptors (nAChRs) mediate fast excitatory neurotransmission in neurons and muscles. To identify nAChR accessory proteins, which may regulate their expression or function, we performed tandem affinity purification ..
  43. ncbi Twist and Notch negatively regulate adult muscle differentiation in Drosophila
    S Anant
    National Centre for Biological Sciences, Bangalore, India
    Development 125:1361-9. 1998
    ..relationship between Notch function and twist regulation during indirect flight muscle development and show that decline in Twist levels is a requirement for the differentiation of these muscles, unlike the somatic muscles of the embryo.
  44. pmc Muscle giants: molecular scaffolds in sarcomerogenesis
    Aikaterini Kontrogianni-Konstantopoulos
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Physiol Rev 89:1217-67. 2009
    Myofibrillogenesis in striated muscles is a highly complex process that depends on the coordinated assembly and integration of a large number of contractile, cytoskeletal, and signaling proteins into regular arrays, the sarcomeres...
  45. ncbi The Caenorhabditis elegans MYOD homologue HLH-1 is essential for proper muscle function and complete morphogenesis
    L Chen
    Carnegie Institute of Washington, Department of Embryology, Baltimore, MD 21210
    Development 120:1631-41. 1994
    ..of this family in Caenorhabditis elegans identified a single family member, hlh-1, which is expressed in striated muscles and their clonal precursors. We have isolated a null allele of hlh-1 following chemical mutagenesis...
  46. pmc Self-renewal and expansion of single transplanted muscle stem cells
    Alessandra Sacco
    Baxter Laboratory in Genetic Pharmacology, Department of Microbiology and Immunology, Stem Cell Institute, Stanford University School of Medicine, Stanford, California 94305 5175, USA
    Nature 456:502-6. 2008
    ....
  47. doi Differential proteomic responses in hepatopancreas and adductor muscles of the green-lipped mussel Perna viridis to stresses induced by cadmium and hydrogen peroxide
    Priscilla T Y Leung
    The Swire Institute of Marine Science and School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    Aquat Toxicol 105:49-61. 2011
    ..Our results suggested that investigations on these stress-associated protein changes could be used as a new and complementary approach in pollution monitoring by this popular biomonitor species...
  48. pmc Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates
    Ronen Schweitzer
    Shriners Hospital for Children, Research Division, Portland, OR 97239, USA
    Development 137:2807-17. 2010
    ..represents an intricate process of tissue assembly involving heterotypic inductive interactions between tendons, muscles and cartilage...
  49. ncbi Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies
    Chun Hong Zhu
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Aging Cell 6:515-23. 2007
    ..We demonstrate that it functions as well as young myoblasts in xenotransplant experiments in immunocompromized mice under conditions of regeneration following muscle damage...
  50. pmc A comparative study of Drosophila and human A-type lamins
    Sandra R Schulze
    Department of Biology, Western Washington University, Bellingham, Washington, United States of America
    PLoS ONE 4:e7564. 2009
    ..These studies provide new insights on the role of lamins in nuclear biology and support Drosophila as a model for studies of human laminopathies involving muscle dysfunction...
  51. ncbi The gene tinman is required for specification of the heart and visceral muscles in Drosophila
    R Bodmer
    Department of Biology, University of Michigan, Ann Arbor 48109 1048
    Development 118:719-29. 1993
    ..Even though tinman mutant embryos do not have a heart or visceral muscles, many of the somatic body wall muscles appear to develop although abnormally...
  52. pmc An integrated strategy for analyzing the unique developmental programs of different myoblast subtypes
    Beatriz Estrada
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Genet 2:e16. 2006
    ..This integrated strategy for examining embryonic gene expression and function provides a substantially expanded framework for further studies of this model developmental system...
  53. pmc Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
    Isaac M Chiu
    Program in Cellular and Molecular Medicine, Immune Disease Institute, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:20960-5. 2009
    ..These data reveal a progressive innate and humoral immune response in peripheral nerves that is separate and distinct from spinal cord immune activation in ALS transgenic mice...
  54. pmc Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability
    Chi F Lee
    Department of Biology and the Molecular Biology Institute, San Diego State University, San Diego, CA 92182, USA
    J Cell Sci 124:699-705. 2011
    ..At 14 hours, it accumulates most strongly in embryonic striated muscles, similarly to muscle myosin...
  55. pmc Coordination of opposing sex-specific and core muscle groups regulates male tail posture during Caenorhabditis elegans male mating behavior
    Allyson J Whittaker
    Division of Biology Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    BMC Biol 7:33. 2009
    ..We provide a better understanding of the molecular and neuro-muscular pathways that regulate male tail posture during mating...
  56. pmc X chromosome-linked muscular dystrophy (mdx) in the mouse
    G Bulfield
    Proc Natl Acad Sci U S A 81:1189-92. 1984
    ..Linkage analysis with four X chromosome loci indicates that mdx maps in the Hq Bpa region of the mouse X chromosome. This gives a gene order of mdx-Tfm-Pgk-1-Ags, the same as for the equivalent genes on the human X chromosome...
  57. ncbi A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes
    Brian N Finck
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 1:133-44. 2005
    ..These results identify PPARalpha-driven alterations in muscle fatty acid oxidation and energetics as a potential link between obesity and the development of glucose intolerance and insulin resistance...
  58. ncbi Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle
    R Kambadur
    AgResearch, Ruakura, Hamilton, New Zealand
    Genome Res 7:910-6. 1997
    ..It therefore appears likely that the mh allele in these breeds involves mutation within the myostatin gene and that myostatin is a negative regulator of muscle growth in cattle as well as mice...
  59. doi dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner
    Kushal Kr Banerjee
    Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, Mumbai 400005, India
    Cell Rep 2:1485-91. 2012
    ..life span phenotype of dSir2 perturbations (both knockdown and overexpression) in the fat body, but not muscles, negates the effects of background genetic mutations...
  60. ncbi Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle
    D Yaffe
    Nature 270:725-7. 1977
  61. ncbi Mutations affecting the indirect flight muscles of Drosophila melanogaster
    I I Deak
    J Embryol Exp Morphol 69:61-81. 1982
    The development of the indirect flight muscles of Drosophila melanogaster was studied by analysing mutations that cause flightlessness. Twenty-five mutations on the X-chromosome and two on the third chromosome were examined...
  62. ncbi The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor
    B A Bamber
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Neurosci 19:5348-59. 1999
    ..Together these data argue that UNC-49B and UNC-49C coassemble at the C. elegans neuromuscular junction. Thus, C. elegans is able to encode a heteromeric GABA receptor with a single locus...
  63. doi Decoding muscle alternative splicing
    Miriam Llorian
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Curr Opin Genet Dev 21:380-7. 2011
    ....
  64. ncbi The frequency of revertants in mdx mouse genetic models for Duchenne muscular dystrophy
    I Danko
    Department of Pediatrics, Waisman Center, University of Wisconsin, Madison 53705
    Pediatr Res 32:128-31. 1992
    ..The mdx3cv dystrophin mouse mutant may be a useful model for some types of human dystrophin deficiencies in which the levels of dystrophin are low but not completely absent...
  65. ncbi C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes
    A Craig Mackinnon
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Curr Biol 12:787-97. 2002
    ..ILK has been implicated in integrin-mediated signaling and is also an adaptor within integrin-associated cytoskeletal complexes...
  66. pmc Muscle regeneration in dystrophin-deficient mdx mice studied by gene expression profiling
    R Turk
    Center for Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, Nederland
    BMC Genomics 6:98. 2005
    ..To characterize the molecular processes associated with regeneration, we compared gene expression levels in hindlimb muscle tissue of mdx and control mice at 9 timepoints, ranging from 1-20 weeks of age...
  67. ncbi Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage
    Toshiyuki Motoike
    The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8573, USA
    Genesis 35:153-9. 2003
    ..Studies with these Cre lines provide direct evidence that Flk1(+) cells are progenitors for muscles, in addition to hematopoietic and vascular endothelial cells.
  68. ncbi Neuromuscular synapses can form in vivo by incorporation of initially aneural postsynaptic specializations
    Heather Flanagan-Steet
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
    Development 132:4471-81. 2005
    ..Moreover, many AChR clusters on later-born fast muscle fibers formed at sites that had already been contacted by axons, suggesting heterogeneity in the signaling mechanisms leading to synapse formation by a single axon...
  69. ncbi A zebrafish sox9 gene required for cartilage morphogenesis
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Development 129:5065-79. 2002
    ..Likewise, calcein labeling revealed that early bone formation was largely unaffected in jef (sox9a) mutants. These studies show that jef (sox9a) is essential for both morphogenesis of condensations and overt cartilage differentiation...
  70. ncbi Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion
    Camilla Englund
    Umeå Center for Molecular Pathogenesis, Umea University, Umea, S 901 87, Sweden
    Nature 425:512-6. 2003
    ....
  71. ncbi Defining the regulatory networks for muscle development
    J D Molkentin
    Hamon Center for Basic Research in Cancer, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, 75235 9148, USA
    Curr Opin Genet Dev 6:445-53. 1996
    ..Elucidation of these aspects of the myogenic program is leading to a detailed understanding of the regulatory circuits controlling muscle development...
  72. ncbi Modular proteins from the Drosophila sallimus (sls) gene and their expression in muscles with different extensibility
    Christoph Burkart
    Institut fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Mannheim, D 68167 Mannheim, Germany
    J Mol Biol 367:953-69. 2007
    ..These shorter isoforms would contribute to the high stiffness of IFM. Other muscles in the thorax and legs have longer Sls isoforms with varying amounts of PEVK sequence; all span the I-band to the ..
  73. ncbi Direct regulation of the muscle-identity gene apterous by a Hox protein in the somatic mesoderm
    M Capovilla
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 67084 Strasbourg, France
    Development 128:1221-30. 2001
    ..Finally, we determine that LT1-4 muscles contain more nuclei in the thorax than in the abdomen and we propose that one of the segmental differences under ..
  74. pmc Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
    Katsutaro Morino
    Howard Hughes Medical Institute, Yale University School of Medicine, P O Box 9812, New Haven, CT 06536 8012, USA
    Diabetes 55:S9-S15. 2006
    ..By elucidating the cellular and molecular mechanisms responsible for insulin resistance, these studies provide potential new targets for the treatment and prevention of type 2 diabetes...
  75. ncbi Decreased expression of myogenic transcription factors and myosin heavy chains in Caenorhabditis elegans muscles developed during spaceflight
    Akira Higashibata
    Japan Aerospace Exploration Agency, 2 1 1, Sengen, Tsukuba, Ibaraki 305 8505, Japan
    J Exp Biol 209:3209-18. 2006
    ....
  76. ncbi Muscle organization of the cubozoan jellyfish Tripedalia cystophora Conant 1897
    Richard A Satterlie
    Center for Marine Science, University of North Carolina Wilmington, 5600 Marvin K Moss Lane, Wilmington, North Carolina 28409, USA
    Biol Bull 209:154-63. 2005
    ....
  77. doi Structure and occurrence of cyphonautes larvae (bryozoa, ectoprocta)
    Claus Nielsen
    The Natural History Museum of Denmark, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    J Morphol 271:1094-109. 2010
    ..membranacea using SEM and CLSM are also reported. The overall configuration of muscles, nerves, and cilia of the two larvae are identical. However, the larva of H...
  78. ncbi wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis
    M K Baylies
    Development 121:3829-37. 1995
    The final pattern of the Drosophila larval body wall muscles depends critically on the prior segregation of muscle founder cells...
  79. pmc Expression-guided in silico evaluation of candidate cis regulatory codes for Drosophila muscle founder cells
    Anthony A Philippakis
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Comput Biol 2:e53. 2006
    ..We have confirmed this hypothesis by experimentally discovering six (out of 12 tested) new CRMs driving expression in the embryonic mesoderm, four of which drive expression in founder cells...
  80. ncbi Presynaptic development at the Drosophila neuromuscular junction: assembly and localization of presynaptic active zones
    A Prokop
    Department of Zoology, University of Cambridge, United Kingdom
    Neuron 17:617-26. 1996
    ..the embryonic neuromuscular junction of Drosophila can form in mutants where development of postsynaptic somatic muscles is affected...
  81. ncbi The development of adult muscles in Drosophila: ablation of identified muscle precursor cells
    K S Broadie
    Department of Zoology, Cambridge, UK
    Development 113:103-18. 1991
    ..These cells are the precursors of adult muscles. Each late twist-expressing cell begins to divide early in the second larval instar and division continues ..
  82. pmc Muscle beta1D integrin reinforces the cytoskeleton-matrix link: modulation of integrin adhesive function by alternative splicing
    A M Belkin
    Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    J Cell Biol 139:1583-95. 1997
    ..This reflects the major role for beta1D integrin in muscle, where extremely stable association is required for contraction...
  83. ncbi who encodes a KH RNA binding protein that functions in muscle development
    E H Baehrecke
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park 20742, USA
    Development 124:1323-32. 1997
    ..These phenotypes indicate that who also functions during metamorphosis, when muscles are reorganized to support adult structures and behavior...
  84. ncbi Molecular integration of inductive and mesoderm-intrinsic inputs governs even-skipped enhancer activity in a subset of pericardial and dorsal muscle progenitors
    S Knirr
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Biol 238:13-26. 2001
    Individual somatic muscles and heart progenitors are specified at defined positions within the mesodermal layer of Drosophila...
  85. ncbi Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
    Sung Hee Um
    Department of Genome Science, Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, Ohio 45237, USA
    Cell Metab 3:393-402. 2006
    ..Thus, S6K1 may mediate deleterious effects, like insulin resistance, and potentially type 2 diabetes in the face of nutrient excess...
  86. doi Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans
    Roger Pocock
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
    Nat Neurosci 11:894-900. 2008
    ..Similar genetic pathways may cause aberrant human brain development under hypoxic conditions...
  87. pmc Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancer
    Wun Jae Kim
    Department of Urology, College of Medicine, Chungbuk National University, Chungbuk, South Korea
    Mol Cancer 9:3. 2010
    ..The aim of this study was to identify genetic signatures associated with disease prognosis in bladder cancer...
  88. pmc The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
    Hansong Deng
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 105:14503-8. 2008
    ..These results suggest that pink1 and parkin are likely not core components of the drp1-mediated mitochondrial fission machinery. Modification of fusion and fission may represent a novel therapeutic strategy for Parkinson's disease...
  89. doi Whole-body cryotherapy in athletes
    Giuseppe Banfi
    IRCCS Galeazzi, School of Medicine, University of Milan, Milan, Italy
    Sports Med 40:509-17. 2010
    ..The published data are generally not controversial, but further studies are necessary to confirm the present observations...
  90. ncbi Regional specification of muscle progenitors in Drosophila: the role of the msh homeobox gene
    A Nose
    National Institute for Basic Biology, Okazaki, Japan
    Development 125:215-23. 1998
    ..to chart the development of muscle progenitors/founders during the formation of distinct groups of mature muscles. We then determined the function of the muscle segment homeobox (msh) gene in myogenesis...
  91. pmc mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
    Jessica J Howell
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, USA
    Trends Endocrinol Metab 22:94-102. 2011
    ..In this review, we detail the current knowledge of the physiological functions of mTORC1 in controlling systemic metabolism, with a focus on advances obtained through genetic mouse models...
  92. ncbi A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    Anne Sophie Van Laere
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
    Nature 425:832-6. 2003
    ..The result supports the long-held view that regulatory mutations are important for controlling phenotypic variation...
  93. ncbi An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action
    Bruno Lomonte
    Facultad de Microbiologia, Instituto Clodomiro Picado, Universidad de Costa Rica, San Jose, Costa Rica
    Toxicon 42:885-901. 2003
    ..This review summarizes the general properties of the Lys49 PLA2 myotoxins, emphasizing the development of current concepts and hypotheses concerning the molecular basis of their toxic activities...
  94. ncbi Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
    P Hasty
    Institute of Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Nature 364:501-6. 1993
    ..Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle...
  95. doi Liver and muscle metabolic changes induced by dietary energy content and genetic selection in rainbow trout (Oncorhynchus mykiss)
    C Kolditz
    Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1067 Nutrition Aquaculture and Genomics, Pôle d Hydrobiologie, Saint Pée sur Nivelle, France
    Am J Physiol Regul Integr Comp Physiol 294:R1154-64. 2008
    ..e., dietary energy content and selection) used in this study to modify muscle lipid content exerted some additive but mostly independent effects on these metabolic actors...
  96. ncbi Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells
    E Bober
    Department of Cell and Molecular Biology, Technical University of Braunschweig, Germany
    Development 120:603-12. 1994
    Limb muscles in vertebrates originate from dermomyotomal cells, which during early development migrate from the ventrolateral region of somites into the limb buds...
  97. ncbi Requirements of DFR1/Heartless, a mesoderm-specific Drosophila FGF-receptor, for the formation of heart, visceral and somatic muscles, and ensheathing of longitudinal axon tracts in CNS
    E Shishido
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo ku, Japan
    Development 124:2119-28. 1997
    ..signals and thus rendered incapable of differentiating into primordia for the heart, visceral and somatic muscles. DFR1 is also required for normal development of the central nervous system...
  98. ncbi Development of spontaneous mouth/tongue movement and related neural activity, and their repression in fetal mice lacking glutamate decarboxylase 67
    Naoko Tsunekawa
    Obata Research Unit, RIKEN Brain Science Institute, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Eur J Neurosci 21:173-8. 2005
    ....
  99. pmc Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation
    Haixia Wang
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, China
    Mol Biol Cell 19:1519-28. 2008
    ..e., E2F2, cyclin D3, and WISP1) are found to be required for myogenin expression, which provides a molecular basis to explain why different p38 isoforms are required for myogenic differentiation...
  100. ncbi A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program
    D G Edmondson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Genes Dev 3:628-40. 1989
    ..Together, these results suggest the existence of a family of myogenic regulatory genes that share a conserved motif with c-myc...
  101. ncbi Wnt4 is a local repulsive cue that determines synaptic target specificity
    Mikiko Inaki
    Department of Physics, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Curr Biol 17:1574-9. 2007
    ..We conducted single-cell microarray analysis of two neighboring muscles (M12 and M13) in Drosophila, which are innervated by distinct motor neurons, by directly isolating them from ..

Research Grants77

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  2. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..that Brn3a and Islet1 are required for pain receptor neurons to correctly connect to their targets in the skin, muscles and spinal cord...
  3. Right ventricular contractile dysfunction after pressure overload
    CLIFFORD RUSSELL GREYSON; Fiscal Year: 2013
    ..in conjunction with a new ex vivo model of acute RV pressure overload employing isolated rat RV papillary muscles. Rat RV papillary muscles subjected to contractile stress, modeling acute RV pressure overload, will be assessed ..
  4. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..degradation, accumulate sphingolipid intermediates and develop a progressive myopathy in the thoracic muscles needed to power flight...
  5. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..It is widely accepted that obstructive apnea is caused largely by abnormal activation of tongue muscles, which are in turn controlled by hypoglossal motoneurons...
  6. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..We propose that [Ca2+]SR -which decays when muscles fatigue- is sustained by SOCE, a universal Ca2+ entry pathway, crucial for mobilizing transcription factors that ..
  7. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..channels play important roles in generation of action potential and in excitation- contraction coupling for heart muscles. Therefore, human model of TS would be a useful platform to study mechanisms of arrhythmia and to test drugs for ..
  8. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..channels play important roles in generation of action potential and in excitation- contraction coupling for heart muscles. Therefore, human model of TS would be a useful platform to study mechanisms of arrhythmia and to test drugs for ..
  9. MR Monitoring of PTC124 Treatment in DMD
    KRISTA H VANDENBORNE; Fiscal Year: 2010
    ..muscle contractile tissue and intramuscular lipid accumulation will be performed in the lower extremity muscles prior to, and at multiple time points following initiation of PTC124 treatment...
  10. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..Microvessels spaced approximately 50 5m apart within brain tissue, are associated with smooth muscles that allow them to constrict and dilate, a process termed functional hyperemia...
  11. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    ..for the nonlinear descriptions needed to incorporate the forces exerted by the tensor tympani and the stapedius muscles, will also be used to understand how these muscles affect sound transmission through the middle ear...
  12. Prevention of age-associated musculoskeletal loss by n-3 fatty acids
    Md Mizanur Rahman; Fiscal Year: 2013
    ..I speculate that mild CR will have very minimal dietary restriction associated bone loss. The muscles and bones act as two parts of the same functional unit of the musculoskeletal system...
  13. Characterization of epsilon-sarcoglycan interacting proteins in mouse brain
    Yuqing Li; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Myoclonus refers to sudden, involuntary jerking of a muscle or group of muscles. Dystonia is defined as a syndrome of sustained muscle contractions, frequently causing twisting and repetitive ..
  14. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..The nerve degeneration causes the subsequent degeneration of the muscles in the extremities...
  15. Use of Interactive Gaming for Enhanced Function after Spinal Cord Injury
    BEATRICE JENNY KIRATLI; Fiscal Year: 2011
    ..The purpose will be to evaluate muscles used, active range of motion, forces generated, heart rate, and other measurable attributes of the actions used ..
  16. Maternal nutrient restriction and nonhuman primate fetal skeletal muscle developm
    Min Du; Fiscal Year: 2010
    ..At 0.9 gestation, fetal gastrocnemius and soleus muscles are sampled for analyses...
  17. Protein alterations in skeletal muscle cells with improved mtDNA repair
    Lyudmila I Rachek; Fiscal Year: 2010
    ..Additionally, evaluate mtDNA damage and mitochondrial dysfunction in skeletal muscles isolated from a mouse model of T2DM (C57BL6 mice fed a high fat diet)...
  18. Secondary Muscle Pathology &Metabolic Dysregulation in Adult with Cerebral Palsy
    Mark Peterson; Fiscal Year: 2013
    ..1) To conduct experiments to identify the discrete cellular etiology of fibro-adipose degeneration of skeletal muscles and metabolic dysregulation among sedentary individuals with CP;(2) To conduct a program of preventive health ..
  19. Role of troponin T isoforms in nemaline myopathy
    Jian Ping Jin; Fiscal Year: 2012
    ..TnT function in ANM may be partially compensated for by the continuing expression of cardiac TnT in skeletal muscles. Functional significance and activation of this compensatory cardiac TnT gene expression will be investigated at ..
  20. Role of Dendritic Ca2+ Transients in Respiratory Rhythm Generation
    Jack L Feldman; Fiscal Year: 2010
    ..and requires that the nervous system generate a reliable and robust rhythm that drives inspiratory and expiratory muscles. The proposed studies will significantly advance our understanding of the neural mechanisms generating ..
  21. Myosin phosphatase autoinhibition in gastrointestinal smooth muscle contraction
    Avril V Somlyo; Fiscal Year: 2012
    ..test the hypothesis that cyclic nucleotide-induced de-autoinhibition of MLCP in different gastrointestinal smooth muscles is mediated by multiple, but dominated by different pathways to relax Ca2+ sensitized force...
  22. Pharmacological strategies to improve breathing after cervical spinal cord injury
    FRANCIS GOLDER; Fiscal Year: 2009
    ..causes life-threatening respiratory failure by decreasing function of the neural cells that control respiratory muscles, the respiratory motoneurons...
  23. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ..Even in adipocytes and muscles, however, many critical steps in this process are not fully understood...
  24. Activity Dependent Signaling in Adult Skeletal Muscle Fiber Plasticity
    Martin F Schneider; Fiscal Year: 2012
    ..Skeletal muscles are composed of different fiber types, and the expression of muscle fiber type-specific genes is modulated by the ..
  25. Respiratory motor control and blood pressure regulation after spinal cord injury
    ALEXANDER VLADIMIROVICH OVECHKIN; Fiscal Year: 2013
    ..impediment to rehabilitation after SCI is respiratory insufficiency due to paresis and paralysis of respiratory muscles. Physiologically, these respiratory and cardiovascular dysfunctions are closely related...
  26. Epigenetic regulation of stem cell senescence in aging
    DAVID TOCHUKWU ASUZU; Fiscal Year: 2011
    ..be the major contributor to age-related GI problems due to degeneration of the enteric nervous system and smooth muscles. However, little is known of age-related changes to ICC, the pacemaker cells of the gut...
  27. Mapping Orofacial Nociceptive Pathways and Alterations Due to Inflammation
    JOSHUA EMRICK; Fiscal Year: 2013
    ..arise in the dental pulp (pulpitis), connective tissues supporting the dentition (gingivitis and periodontitis), muscles involved in mastication (myositis), or temporomandibular joint (arthritis or temporomandibular disorder/TMD)...
  28. Neural Representation of Reach-to-Grasp for Cortical FES Neuroprostheses
    Abidemi Bolu Ajiboye; Fiscal Year: 2012
    ..FES systems typically require SCI persons to retain some volitional movement such as contraction of muscles or movement of joints above the line of injury...
  29. High Throughput Screening of the Autoimmune Epitome
    Nancy J Olsen; Fiscal Year: 2010
    ..Area (04) Clinical Research and specific Challenge Topic 04-AR-101 Autoimmunity for Diseases of Skin, Joints, Muscles and Other Tissues...
  30. Development and Regulation of Cholinergic Synapses
    Andres Villu Maricq; Fiscal Year: 2013
    ..Rapid cholinergic neurotransmission at muscles and in the brain is via synaptically released acetylcholine (ACh), which binds to and activates ion-channel ..
  31. Identification and Validation of Alcohol Biomarker Signatures by Proteomics
    Emanuel Rubin; Fiscal Year: 2010
    ..A chronic effect of alcohol on the structure and function of the muscles has been shown to induce changes in several proteins and pathways...
  32. Striated Muscle Gene Transcription and Regulatory Gene Cassettes for Gene Therapy
    STEPHEN DENISON HAUSCHKA; Fiscal Year: 2012
    ..an informative model because it is expressed in skeletal and cardiac muscle, and at varying levels in different muscles &fast/slow muscle fibers...
  33. Optimization of HDAC6 Inhibitors in the Treatment of CMT
    Ludo Van Den Bosch; Fiscal Year: 2013
    ..CMT affects both motor and sensory nerves. A typical characteristic includes weakness of the foot and lower leg muscles, which may result in foot drop and a high-stepped gait with frequent tripping or falls...
  34. Rocker Shoes for Natural Immobilization of the Ankle during Single Limb Support
    Andrew H Hansen; Fiscal Year: 2012
    ..reduce the need for muscular contractions across the ankle joint, leading to atrophy and weakness of the leg muscles. Walking casts and boots are also highly noticeable interventions that may negatively affect patient compliance...
  35. REACTIVE OXYGEN SPECIES: STRESS AND DAMAGE IN OLD MUSCLE
    Susan V Brooks; Fiscal Year: 2012
    ..In addition, CuZnSOD activity was rescued separately in nerves, Sod1-/-(N) mice, and muscles, Sod1-/-(M) mice, to address additional hypotheses related to the specific tissues in which oxidative stress is ..
  36. Regenerative Adjuvant Therapy for Stress Urinary Incontinence
    Margot S Damaser; Fiscal Year: 2011
    ..method for the maternal injuries of childbirth is pelvic floor (Kegel) exercises which strengthen the muscles of the pelvic floor and prevent leakage between voids...
  37. Visualization of Pelvic Floor Reflexes
    CHRISTOS EURIPIDES CONSTANTINOU; Fiscal Year: 2010
    ..Modified Specific Aim Sections The function of the female Pelvic Floor (PF), which encompasses Pelvic Floor Muscles (PFM), bladder and urethral support, constitutes a very important element in addressing the problem of female ..
  38. Molecular mechanism of regulation of mI(CAT) in intestinal smooth muscle cells
    Michael X Zhu; Fiscal Year: 2012
    ..Most visceral smooth muscles co-express both type 2 and type 3 mAChRs (M2R and M3R)...
  39. The survival of motor neuron protein in axonal mRNA localization
    PAUL GREGORY DONLIN-ASP; Fiscal Year: 2013
    ..SMA is characterized by gradual loss of motor neurons leading to failed innervation of muscles which results in progressive muscle weakness and eventual death due to respiratory distress...
  40. Enhancing Plasticity in Damaged Spinal Cord to Repair Transmission and Function
    Victor L Arvanian; Fiscal Year: 2013
    ..1) strengthening synaptic connections through the injury epicenter to lumbar motoneurons, and then to hindlimb muscles (electrophysiology);(2) anatomical plasticity of fibers accounting for the persistence of the synaptic response ..
  41. Intravenous Protein Therapy for Treatment of Congenital Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..intracellular contractile apparatus, the muscle membrane, and extracellular basal lamina, and as a consequence muscles become abnormally sensitive to damage...
  42. Genetic control of quantitative traits associated with the metabolic syndrome
    Maria De Luca; Fiscal Year: 2013
    ..g. basal proton leak) in skeletal muscles. We have also shown that variation in mitochondrial state 4 respiration rates in skeletal muscles is negatively ..
  43. Role of Rab GAPs AS160 and Tbc1d1 in GLUT4 translocation and glucose homeostasis
    Susanna R Keller; Fiscal Year: 2013
    ..mice suggest that glucose uptake is regulated by AS160 in adipocytes, and by AS160 and Tbc1d1 in skeletal muscles. Our hypothesis is that AS160 and Tbc1d1 each alone control GLUT4 intracellular retention and release to the ..
  44. Neurotrophin-Secreting Muscle Stem Cell Therapy for Laryngeal Paralysis
    Stacey L Halum; Fiscal Year: 2013
    ..feasible techniques to enhance physiologic pathways involved in neural regeneration to selected laryngeal muscles while preventing functional antagonistic reinnervation, thereby potentially restoring vocal fold motion...
  45. 2011 Cell-Cell Fusion Gordon Research Conference and Seminar
    NANCY RYAN GRAY; Fiscal Year: 2011
    ..Important processes such as membrane fusion and fission, egg-sperm fusion, formation of bones, muscles, eye lens, stem cells, placenta, rare genetic diseases, and the invasion of cells by pathogens will be covered in ..
  46. In vivo Studies of Creatine Kinase Kinetics by 31P Magnetization Transfer MRS
    Adil Bashir; Fiscal Year: 2013
    ..The major problems arise from long examination time and signal contamination from the skeletal muscles in chest wall, which is further exacerbated by respiratory motion...
  47. RESPIRATORY PATTERN GENERATION STUDIED IN VITRO
    Jack L Feldman; Fiscal Year: 2012
    ..and requires that the nervous system generate a reliable and robust rhythm that drives inspiratory and expiratory muscles. The proposed studies will significantly advance our understanding of the neural mechanisms generating ..
  48. CRCNS: Computation-Enabled Adaptive Ventilatory Control System
    Ranu Jung; Fiscal Year: 2013
    ..More recently, intramuscular stimulation of multiple respiratory muscles has been proposed as a viable less surgically invasive approach, in particular for people with insufficient ..
  49. Excitation-contraction Coupling in Normal and Dystrophic Mammalian Muscle
    Julio L Vergara; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: In Duchenne Muscular Dystrophy (DMD) the muscles lack the protein dystrophin, an integral component of a dystrophin-glycoprotein complex (DGC)...
  50. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    FRANCES ANN WALKER; Fiscal Year: 2012
    ..Chagas'disease slowly weakens the autonomic muscles of the heart, lungs and/or gut and thereby may cause death some 30 or more years later. There is no cure...
  51. Dual AAV Vectors for Duchenne Muscular Dystrophy Therapy
    Dongsheng Duan; Fiscal Year: 2012
    ..gene mutations lead to Duchenne muscular dystrophy (DMD), a severe muscle disease that affected nearly all muscles in the body. A cure for DMD requires body-wide therapy...
  52. Aging, Inflammation and Exercise in Chronic Stroke
    Alice S Ryan; Fiscal Year: 2012
    ..JNK, IRS1- Ser307, Akt and p-38 MAPK phosphorylation) and GS activity in hemiparetic and nonparetic leg skeletal muscles. To accomplish these aims, 90 subjects (n=18 controls and n=72 hemiparetic stroke patients) aged 55-75 years, BMI ..
  53. Control of Breathing and Pompe Disease
    David D Fuller; Fiscal Year: 2013
    ..in Pompe disease is that brainstem neurons and spinal cord motoneurons fail to adequately control the respiratory muscles. This renewal application targets optimization of adeno-associated virus (AAV) based therapies to treat ..
  54. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
    ..Prostaglandins and adenosine are important by-products in active muscles and engaged in the abnormal reflex response in HF...
  55. ROLE AND REGULATION OF PROTEIN KINASE C ISOENZYMES
    Yusuf Awni Hannun; Fiscal Year: 2013
    ..processes that depend on availability of key proteins and/or lipids at the PM, including regulation of smooth muscles and endothelial cells, both of great importance to vascular biology...
  56. The Molecular Basis of Muscle Wasting in Cancer Cachexia
    SUSAN KANDARIAN; Fiscal Year: 2013
    ..be accomplished by overexpressing plasmids that encode dominant negative forms of NF-?B signaling proteins in muscles of tumor and non-tumor bearing mice...
  57. Cullin mediated protein turnover in skeletal and cardiac muscles
    Stephan Lange; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cullin mediated protein turnover in skeletal and cardiac muscles The regulated degradation of proteins is an important mechanism for the survival of cells...
  58. Diagnosis of sub-clinical cryptic group A streptococcal myonecrosis
    Amy Evelyn Bryant; Fiscal Year: 2013
    ..first time, 1) the well-known ability of GAS exotoxins to modify host proteins plus 2) the knowledge that injured muscles express unique proteins during regeneration, as the basis for a novel approach to diagnosis...
  59. Targeting fibrocytes in Duchenne muscular dystrophy
    Lan Zhou; Fiscal Year: 2013
    ..their ligands can inhibit fibrocyte recruitment and fibrogenic functions and ameliorate fibrosis in dystrophic muscles. We will address our hypothesis through three Specific Aims...
  60. Nitrergic Neuro-smooth Muscle Transmission in the Gut
    Raj K Goyal; Fiscal Year: 2013
    ..by applicant): Nitric oxide (NO) is an important inhibitory neurotransmitter for the gastrointestinal smooth muscles. As a neurotransmitter, NO plays a key role in peristalsis and physiological relaxation of the sphincters and ..
  61. Role of the Giant Protein Titin in Skeletal Muscle Structure and Function
    Henk L Granzier; Fiscal Year: 2013
    ..We will investigate how titin's contribution to passive stiffness varies in different muscles, depending on differential splicing and posttranslational modifications in titin...
  62. Somatosensory feedback controlling a neuroprosthesis
    Douglas J Weber; Fiscal Year: 2010
    ..for closed-loop control of functional electrical stimulation systems, which are used to restore action to muscles paralyzed by spinal cord or other central nervous system injuries...
  63. Exogenous growth factors for reversal of age-related laryngeal muscle denervation
    Joseph Stemple; Fiscal Year: 2011
    ..In the elderly, age-related changes in the intrinsic laryngeal muscles may compromise voice quality, thus impair the ability to communicate and diminish the ability to remain socially ..
  64. Intravenous Protein Therapy for the Treatment of Duchenne Muscular Dystrophy
    BRADLEY HODGES; Fiscal Year: 2009
    ..protein which tethers the contractile apparatus to the membrane and basal lamina of skeletal and cardiac muscles and protects myofibers from the shear forces of muscle contraction...
  65. Myogenic Potential of Extraocular Muscle Satellite Cells
    Linda K McLoon; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The extraocular muscles (EOM) are spared in Duchenne muscular dystrophy patients (DMD) and continue to function after most skeletal muscles in the body have completely degenerated...
  66. Molecular mechanisms of aging in the intrinsic laryngeal muscles
    Colleen McMullen; Fiscal Year: 2009
    ..In the elderly, age-related changes in the intrinsic laryngeal muscles may compromise voice quality, thus, impair the ability to communicate and diminish the ability to remain socially ..
  67. Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough
    Anthony F DiMarco; Fiscal Year: 2010
    ..cough mechanism due to the fact that their injury often results in paralysis of virtually all of their expiratory muscles. Consequently these patients are dependent upon caregiver assistance for the application of manual suctioning, ..
  68. MICROMECHANICS OF RESPIRATORY MUSCLES
    ALADIN BORIEK; Fiscal Year: 1999
    The respiratory muscles are a major determinant of thoracic cavity shape and; therefore, of the regional ventilation distribution. Respiratory insufficiency is the cause of death in many primary neuromuscular disorders...
  69. AMES+Brain Stimulation: Treatment for Profound Plegia in Stroke
    Paul Cordo; Fiscal Year: 2010
    ..While some plegic stroke patients have completely paralyzed muscles, without the ability to activate even minimally the plegic muscles ("profound plegia"), other plegic stroke ..
  70. HISTOINCOMPATIBLE MYOBLAST INJECTION AGAINST DYSTROPHY
    Peter Law; Fiscal Year: 1992
    ..co-culture) into dystrophic solei of histocompatible mice improved the structure and functions of the muscles to almost normal...
  71. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..and thermal hyperalgesia of FM and NC subjects in relation to carefully controlled tonic pain manipulation of muscles. We posit that local spontaneous pain in FM is strongly indicative of local and widespread thermal and mechanical ..
  72. Respiratory activities of intrinsic tongue muscles
    E Bailey; Fiscal Year: 2004
    ..both intrinsic (origin and insertion in the tongue) and extrinsic (attached to bone and inserted into the tongue) muscles. These muscles play a key role in swallowing, breathing, chewing, and speaking...
  73. Aging, AMP Kinase and Skeletal Muscle Overload
    Scott Gordon; Fiscal Year: 2005
    ..was tightly and negatively correlated with the degree of overload-induced hypertrophy in fast-twitch muscles. The first aim of this investigation is to determine if elevated AMPK activity is responsible for the age-related ..
  74. LIPID AND PROTEIN PO4 TURNOVER IN IRIS OF THE EYE
    ATA ABDEL LATIF; Fiscal Year: 1999
    ..and its derived second messengers in agonist-induced muscle contraction in the sphincter and dilator smooth muscles of the iris-ciliary body, (b) to seek novel interactions between the cAMP and IP3-DG-CA2+ second messenger ..
  75. Characterization of Endpoint Mechanical Actions of Thumb Muscles
    Joseph D Towles; Fiscal Year: 2011
    ..An understanding of the three-dimensional thumb-tip forces normally produced by flexor, abductor and adductor muscles and certain combinations of those muscles could provide a scientific basis for evaluating current surgeries and, ..
  76. Applying a Multidimensional Algorithm for Motor Control
    Emilio Bizzi; Fiscal Year: 2010
    ..additionally challenging by the fact that successful production of any movement necessitates coordination of many muscles representing many degrees of freedom...
  77. Spinal Cord Stimulation to Restore Cough In Humans
    Anthony DiMarco; Fiscal Year: 2007
    ..Patients with cervical and thoracic spinal cord injuries have paralysis of a major portion of their expiratory muscles and therefore, lack a normal cough mechanism...