ligaments

Summary

Summary: Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.

Top Publications

  1. ncbi The effect of focused extracorporeal shock wave therapy on collagen matrix and gene expression in normal tendons and ligaments
    G Bosch
    Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12, 3584 CM Utrecht, The Netherlands
    Equine Vet J 41:335-41. 2009
  2. pmc Combined high-resolution magnetic resonance imaging and histological examination to explore the role of ligaments and tendons in the phenotypic expression of early hand osteoarthritis
    A L Tan
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 65:1267-72. 2006
  3. ncbi Sensory-motor control of ligaments and associated neuromuscular disorders
    M Solomonow
    Musculoskeletal Disorders Research Laboratory, Bioengineering Section, Department of Orthopaedic Surgery, University of Colorado at Denver and Health Sciences Center, 12800 East 19th Avenue, Aurora, Denver, CO 80045, USA
    J Electromyogr Kinesiol 16:549-67. 2006
  4. pmc New insights into mutable collagenous tissue: correlations between the microstructure and mechanical state of a sea-urchin ligament
    Ana R Ribeiro
    Instituto de Engenharia Biomedica, Biomaterials Division, NewTherapies Group, Universidade do Porto, Porto, Portugal
    PLoS ONE 6:e24822. 2011
  5. ncbi Biomechanical role of lumbar spine ligaments in flexion and extension: determination using a parallel linkage robot and a porcine model
    Kevin A Gillespie
    Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Spine (Phila Pa 1976) 29:1208-16. 2004
  6. ncbi A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I
    O Brandau
    Department of Experimental Pathology, Lund University, Lund, Sweden
    Dev Dyn 221:72-80. 2001
  7. doi Magnetic resonance imaging of the ankle at 3.0 Tesla and 1.5 Tesla in human cadaver specimens with artificially created lesions of cartilage and ligaments
    Jan S Bauer
    Department of Radiology, Technical University, Munich, Germany
    Invest Radiol 43:604-11. 2008
  8. ncbi Sectional imaging anatomy: pelvic ring ligaments
    N Attias
    Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030-3498, USA
    J Comput Assist Tomogr 25:975-9. 2001
  9. doi Wild-type transthyretin-derived amyloidosis in various ligaments and tendons
    Takanao Sueyoshi
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Hum Pathol 42:1259-64. 2011
  10. ncbi The cell and developmental biology of tendons and ligaments
    M Benjamin
    Anatomy Unit, School of Biosciences, Cardiff University, United Kingdom
    Int Rev Cytol 196:85-130. 2000

Detail Information

Publications279 found, 100 shown here

  1. ncbi The effect of focused extracorporeal shock wave therapy on collagen matrix and gene expression in normal tendons and ligaments
    G Bosch
    Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12, 3584 CM Utrecht, The Netherlands
    Equine Vet J 41:335-41. 2009
    ..Extracorporeal shock wave therapy (ESWT) is frequently used in equine practice, but little is known about its biological action...
  2. pmc Combined high-resolution magnetic resonance imaging and histological examination to explore the role of ligaments and tendons in the phenotypic expression of early hand osteoarthritis
    A L Tan
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 65:1267-72. 2006
    ..of the early stages of hand osteoarthritis is poorly understood, but recent high-resolution magnetic resonance imaging (hrMRI) studies suggest that the joint ligaments have a major role in the phenotypic expression of the disease.
  3. ncbi Sensory-motor control of ligaments and associated neuromuscular disorders
    M Solomonow
    Musculoskeletal Disorders Research Laboratory, Bioengineering Section, Department of Orthopaedic Surgery, University of Colorado at Denver and Health Sciences Center, 12800 East 19th Avenue, Aurora, Denver, CO 80045, USA
    J Electromyogr Kinesiol 16:549-67. 2006
    The ligaments were considered, over several centuries, as the major restraints of the joints, keeping the associated bones in position and preventing instability, e.g. their separation from each other and/or mal-alignment...
  4. pmc New insights into mutable collagenous tissue: correlations between the microstructure and mechanical state of a sea-urchin ligament
    Ana R Ribeiro
    Instituto de Engenharia Biomedica, Biomaterials Division, NewTherapies Group, Universidade do Porto, Porto, Portugal
    PLoS ONE 6:e24822. 2011
    ..Further evidence that the juxtaligamental cells are the effectors of these changes in mechanical properties was provided by a correlation between their cytology and the tensile state of the CDLs...
  5. ncbi Biomechanical role of lumbar spine ligaments in flexion and extension: determination using a parallel linkage robot and a porcine model
    Kevin A Gillespie
    Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Spine (Phila Pa 1976) 29:1208-16. 2004
    ..Porcine lumbar spine specimens were cyclically loaded in flexion and extension with a pure moment. The resistance to flexion and extension of the individual spinal elements was quantified using a sequential resection procedure...
  6. ncbi A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I
    O Brandau
    Department of Experimental Pathology, Lund University, Lund, Sweden
    Dev Dyn 221:72-80. 2001
    ..In 17.5-day-old mouse embryos, in situ hybridization revealed high levels of tendin transcript in tendons and ligaments. Additional signals were detected in brain and spinal cord, liver, lung, bowels, thymus, and eye...
  7. doi Magnetic resonance imaging of the ankle at 3.0 Tesla and 1.5 Tesla in human cadaver specimens with artificially created lesions of cartilage and ligaments
    Jan S Bauer
    Department of Radiology, Technical University, Munich, Germany
    Invest Radiol 43:604-11. 2008
    ..To compare magnetic resonance imaging of the ankle joint at 1.5 Tesla (T) and 3.0 T in the assessment of cartilage and ligament pathology in fresh human cadaver specimens...
  8. ncbi Sectional imaging anatomy: pelvic ring ligaments
    N Attias
    Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030-3498, USA
    J Comput Assist Tomogr 25:975-9. 2001
    The purpose of this article is to describe the complex anatomy of the pelvic ligaments. It uses schematics to display 10 color-coded ligaments in relation to the bony architecture...
  9. doi Wild-type transthyretin-derived amyloidosis in various ligaments and tendons
    Takanao Sueyoshi
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Hum Pathol 42:1259-64. 2011
    Transthyretin-derived amyloid deposition is commonly found in intercarpal ligaments of patients with senile systemic amyloidosis...
  10. ncbi The cell and developmental biology of tendons and ligaments
    M Benjamin
    Anatomy Unit, School of Biosciences, Cardiff University, United Kingdom
    Int Rev Cytol 196:85-130. 2000
    ..review, a modern synthesis of opinion on the cell, developmental, and molecular biology of tendons, ligaments, and their associated structures (tendon sheaths, vinculi, and retinacula)...
  11. doi The sacroiliac spine - computer simulation of motion and modeling of the ligaments
    William L Buford
    Univ of Texas Medical Branch UTMB, Galveston, TX 77555, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:5117-20. 2010
    ..The major ligaments are added to the simulation data structure using deformable cubic B-spline curve paths...
  12. ncbi Age-related changes of elements and relationships among elements in human tendons and ligaments
    Motohisa Yamada
    Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Biol Trace Elem Res 98:129-42. 2004
    To elucidate compositional changes of the tendons and ligaments with aging, the authors investigated age-related changes of element contents in the insertion tendons of the biceps brachii muscle, central tendons of the diaphragma, ..
  13. ncbi Trace elements in human tendons and ligaments
    Tsukasa Kumai
    Laboratory of Cell Biology, Department of Anatomy, Nara Medical University, Kashihara, Nara 634 8522, Japan
    Biol Trace Elem Res 114:151-61. 2006
    Tendons and ligaments are key structures in promoting joint movement and maintaining joint stability...
  14. ncbi Three-dimensional finite element modeling of ligaments: technical aspects
    Jeffrey A Weiss
    Department of Bioengineering, University of Utah, 50 South Central Campus Drive, Room 2480, Salt Lake City, UT 84112, USA
    Med Eng Phys 27:845-61. 2005
    ..of this paper is to describe strategies for addressing technical aspects of the computational modeling of ligaments with the finite element (FE) method...
  15. doi The effect of growth factors on both collagen synthesis and tensile strength of engineered human ligaments
    Paul Hagerty
    Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, CA 95616, USA
    Biomaterials 33:6355-61. 2012
    ..designed array of varying concentrations of growth factors and ascorbic acid were applied to engineered ligaments and the collagen content and mechanics of the grafts were determined...
  16. doi A nonlinear constitutive model for stress relaxation in ligaments and tendons
    Frances M Davis
    Mechanics of Soft Biological Systems Laboratory, Department of Engineering Science and Mechanics, Virginia Tech, Blacksburg, VA 24061, USA
    Ann Biomed Eng 40:2541-50. 2012
    ..constitutive model that describes stress relaxation in transversely isotropic soft collagenous tissues such as ligaments and tendons is presented...
  17. pmc Carpal tunnel expansion by palmarly directed forces to the transverse carpal ligament
    Zong Ming Li
    Department of Orthopaedic Surgery, Hand Research Laboratory, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Biomech Eng 131:081011. 2009
    ..The model illustrated the effectiveness of carpal tunnel expansion by TCL elongation or arch width narrowing...
  18. ncbi Numbering of lumbosacral transitional vertebrae on MRI: role of the iliolumbar ligaments
    Richard J Hughes
    Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, London, England HA7 4LP
    AJR Am J Roentgenol 187:W59-65. 2006
    The objective of this study was to determine whether identification of the iliolumbar ligaments is of practical use for numbering lumbosacral transitional vertebrae (LSTV).
  19. doi Probabilistic constitutive law for damage in ligaments
    Zheying Guo
    Mechanics of Soft Biological Systems Laboratory, Engineering Science and Mechanics Department, 230 Norris Hall, Virginia Tech, Blacksburg, VA 24061, USA
    Med Eng Phys 31:1104-9. 2009
    ..equation is presented to describe the damage evolution process in parallel-fibered collagenous tissues such as ligaments. The model is formulated by accounting for the fibrous structure of the tissues...
  20. doi Heberden's nodes and what Heberden could not see: the pivotal role of ligaments in the pathogenesis of early nodal osteoarthritis and beyond
    D McGonagle
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Rheumatology (Oxford) 47:1278-85. 2008
    ..cartilage or bone disease, this article offers a viewpoint on why GOA may, in fact, be primarily a disorder of ligaments, and to a lesser extent tendon and joint capsule dysfunction...
  21. doi Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments
    Shunfu Chin
    Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Biochem Biophys Res Commun 436:698-704. 2013
    ..In our previous in vitro study, we showed the existence of MSCs in human spinal ligaments and hypothesized that these MSCs contributed to the pathogenesis of ossification of spinal ligaments...
  22. pmc Pro-inflammatory cytokines expression increases following low- and high-magnitude cyclic loading of lumbar ligaments
    Peter D'Ambrosia
    Musculoskeletal Disorders Research Laboratory, Bioengineering Division, Department of Orthopedic Surgery, Health Sciences Center, University of Colorado, Denver, 12800 E 19th Ave, RC 1N, Mail Stop 8343, Box 6511, Aurora, CO 80045, USA
    Eur Spine J 19:1330-9. 2010
    ..Following a 7-h post-loading rest, the supraspinous ligaments of L-3/4, L-4/5 and L-5/6 and the unstimulated T-10/11 were excised for mRNA analysis and IL-1beta, IL-6, IL-8, ..
  23. doi Elastic fiber depletion in the supporting ligaments of the gastroesophageal junction: a structural basis for the development of hiatal hernia
    John A Curci
    Washington University Institute for Minimally Invasive Surgery and the Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Coll Surg 207:191-6. 2008
    The position of the gastroesophageal junction is maintained by a complex of fibroelastic ligaments. The purpose of this study was to characterize and compare the histology of these ligaments in patients with gastroesophageal reflux ..
  24. pmc Functional attachment of soft tissues to bone: development, healing, and tissue engineering
    Helen H Lu
    Columbia University, Department of Biomedical Engineering, New York, NY 10027, USA
    Annu Rev Biomed Eng 15:201-26. 2013
    Connective tissues such as tendons or ligaments attach to bone across a multitissue interface with spatial gradients in composition, structure, and mechanical properties...
  25. pmc Biomechanical interaction between the transverse carpal ligament and the thenar muscles
    Zhilei Liu Shen
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Appl Physiol (1985) 114:225-9. 2013
    ..This study sheds light on the potential cause of TCL hypertrophy, which may be an etiological factor for carpal tunnel syndrome...
  26. ncbi Treatment of Neer type II fractures of the lateral clavicle using distal radius locking plates combined with TightRope augmentation of the coraco-clavicular ligaments
    Erik Hohmann
    Department of Orthopaedic Surgery, Rockhampton Hospital, Rockhampton, Australia
    Arch Orthop Trauma Surg 132:1415-21. 2012
    ..the outcome of Neer type II lateral clavicle fractures treated using a novel technique, which incorporates a superiorly placed distal radius locking plate combined with TightRope™ fixation to augment the coraco-clavicular ligaments.
  27. doi Anatomic variants and pitfalls of the labrum, glenoid cartilage, and glenohumeral ligaments
    Kevin S Dunham
    Department of Radiology, New York University Langone Medical Center, 560 First Avenue, New York, NY 10016, USA
    Magn Reson Imaging Clin N Am 20:213-28, x. 2012
    ..discusses the normal anatomy and anatomic variants of the glenoid labrum, articular cartilage, and glenohumeral ligaments. An improved understanding of normal anatomy, biomechanics, and variants will help to avoid potential pitfalls ..
  28. ncbi Modelling the behaviour of ligaments: a technical note
    Samer Adeeb
    Department of Civil Engineering, University of Calgary, Calgary, AB, Canada
    Comput Methods Biomech Biomed Engin 7:33-42. 2004
    ..Glisson, R. and Parker Vail, T. (2001) "Regional material properties of the human hip joint capsule ligaments", Journal of Orthopaedic Research 19(3), 359-364]) due to the very high level of anisotropy of the tissue; ..
  29. doi Mesenchymal stem cell isolation and characterization from human spinal ligaments
    Toru Asari
    Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Biochem Biophys Res Commun 417:1193-9. 2012
    ..describe isolating MSCs from various human tissues, there are no reports of isolating MSCs from human spinal ligaments, and their localization in situ...
  30. ncbi Evaluation of tartrate-resistant acid phosphatase and cathepsin K in ruptured cranial cruciate ligaments in dogs
    Peter Muir
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
    Am J Vet Res 63:1279-84. 2002
    To determine localization of tartrate-resistant acid phosphatase (TRAP) and cathepsin K in ruptured and healthy cranial cruciate ligaments (CCL) in dogs.
  31. doi Carpal tunnel and transverse carpal ligament stiffness with changes in wrist posture and indenter size
    Michael W R Holmes
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Orthop Res 29:1682-7. 2011
    ..The complexity of the TCL makes it an important part of the carpal tunnel and the mechanical properties found are essential to understanding mechanisms of carpal tunnel syndrome. ..
  32. ncbi Determining the effect of hydration upon the properties of ligaments using pseudo Gaussian stress stimuli
    Allen H Hoffman
    Mechanical Engineering Department, Worcester Polytechnic Institute, 100, Institute Road, Worcester, MA, USA
    J Biomech 38:1636-42. 2005
    ..The material properties of medial collateral rat knee ligaments were studied in relation to hydration, using (sequentially) 0...
  33. ncbi The origins of the thenar and hypothenar muscles
    J Kung
    Department of Orthopaedic Surgery, Baylor College of Medicine, Houston TX, USA
    J Hand Surg Br 30:475-6. 2005
    ..This paper presents an anatomical study of the origins of the thenar and hypothenar muscles and postulates the causes of weakness and pillar pain following carpal tunnel release...
  34. doi Clinical characteristics, pain, and disability in relation to alar ligament MRI findings
    Rigmor Myran
    Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Spine (Phila Pa 1976) 36:E862-7. 2011
    ..Cross-sectional study...
  35. ncbi Cytokines and the role they play in the healing of ligaments and tendons
    C H Evans
    Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Sports Med 28:71-6. 1999
    ..Various cytokines are expressed endogenously during the healing responses of those ligaments and tendons which possess them, and there is evidence that the exogenous application of certain cytokines ..
  36. doi Magnetic resonance imaging of the alar and transverse ligaments in acute whiplash-associated disorders 1 and 2: a cross-sectional controlled study
    Nils Vetti
    Department of Radiology, Haukeland University Hospital, Bergen, Norway
    Spine (Phila Pa 1976) 36:E434-40. 2011
    ..Cross-sectional...
  37. pmc Are MRI high-signal changes of alar and transverse ligaments in acute whiplash injury related to outcome?
    Nils Vetti
    Department of Radiology, Haukeland University Hospital, Bergen, Norway
    BMC Musculoskelet Disord 11:260. 2010
    ..The purpose of this study was to examine if alar and transverse ligament high-signal changes on MRI immediately following the car accident are related to outcome after 12 months for patients with acute WAD grades 1-2...
  38. doi Craniocervical junction in dogs revisited--new ligaments and confirmed presence of enthesis fibrocartilage
    M Kupczyńska
    Institute of Comparative and Clinical Anatomy, Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159, 02 779 Warsaw, Poland
    Res Vet Sci 92:356-61. 2012
    ..Occurrence and distribution of fibrocartilage in the ligaments from 10 dogs was analysed histologically...
  39. ncbi The efficacy of magnetic resonance imaging in pediatric cervical spine clearance
    Joshua B Frank
    Hospital for Joint Diseases, New York University School of Medicine, New York, New York, USA
    Spine (Phila Pa 1976) 27:1176-9. 2002
    ..A retrospective chart analysis of pediatric trauma patients with suspected cervical spine injury was performed...
  40. ncbi Age estimation based on aspartic acid racemization in elastin from the yellow ligaments
    S Ritz-Timme
    Institut für Rechtsmedizin der Christian Albrechts Universität zu Kiel, Arnold Heller Strasse 12, 24105 Kiel, Germany
    Int J Legal Med 117:96-101. 2003
    The yellow ligaments of the spine are characterized by an exceptionally high content of elastin, a protein with a proved longevity in several human tissues...
  41. pmc Regional differences within the human supraspinous and interspinous ligaments: a sheet plastination study
    Gillian M Johnson
    Otago School of Physiotherapy, University of Otago, PO Box 56, Dunedin, New Zealand
    Eur Spine J 11:382-8. 2002
    ..to which neighboring muscles and the fascia contribute to the formation of the supraspinous and interspinous ligaments is not clear from the literature...
  42. ncbi Pelvic nerve plexus trauma at radical and simple hysterectomy: a quantitative study of nerve types in the uterine supporting ligaments
    Simon A Butler-Manuel
    Division of Gynaecological Oncology, St George s Hospital, London, United Kingdom
    J Soc Gynecol Investig 9:47-56. 2002
    ..neuropeptide and enzyme markers to autonomic nerves, we sought to demonstrate and quantify the nerve types contained within the uterosacral ligaments (USLs) and cardinal ligaments (CLs) that are divided during radical hysterectomy (RH).
  43. ncbi Collagen metabolism in the uterosacral ligaments and vaginal skin of women with uterine prolapse
    Christian H Phillips
    Faculty of Medicine Maternal, Fetal and Neonatal Physiology Group, Department of Gynecology, Princess Anne Hospital, Southampton, Hampshire, UK
    BJOG 113:39-46. 2006
    To compare tissue markers of collagen metabolism in the uterosacral ligaments with those in vaginal tissue in women with uterine prolapse.
  44. doi Outcome after lacerations of the superficial and deep digital flexor tendons, suspensory ligament and/or distal sesamoidean ligaments in 106 horses
    Mireia Jordana
    Department of Surgery and Anaesthesiology of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium
    Vet Surg 40:277-83. 2011
    To report outcome after the surgical treatment of lacerations of the superficial digital flexor tendon (SDFT), deep digital flexor tendon (DDFT), suspensory ligament (SL), and/or distal sesamoidean ligaments (DSL) in horses.
  45. doi Sequential biochemical and mechanical stimulation in the development of tissue-engineered ligaments
    Jodie E Moreau
    Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA
    Tissue Eng Part A 14:1161-72. 2008
    ..The current results suggest a dynamic culturing regime in the development of engineered tissues...
  46. doi Effect of hormone replacement and selective estrogen receptor modulators (SERMs) on the biomechanics and biochemistry of pelvic support ligaments in the cynomolgus monkey (Macaca fascicularis)
    Azin Shahryarinejad
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Keck School of Medicine at USC, Los Angeles, CA, USA
    Am J Obstet Gynecol 202:485.e1-9. 2010
    To evaluate the effect of selective estrogen receptor modulators and ethinyl estradiol on the biomechanical and biochemical properties of the uterosacral and round ligaments in the monkey model of menopause.
  47. ncbi A model for loading-dependent growth, development, and adaptation of tendons and ligaments
    T A Wren
    Rehabilitation Research and Development Center, Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
    J Biomech 31:107-14. 1998
    The geometric and material properties of tendons and ligaments change during growth and development...
  48. doi Human cervical spine ligaments exhibit fully nonlinear viscoelastic behavior
    Kevin L Troyer
    Colorado State University, Ft Collins, CO, USA
    Acta Biomater 7:700-9. 2011
    Spinal ligaments provide stability and contribute to spinal motion patterns. These hydrated tissues exhibit time-dependent behavior during both static and dynamic loading regimes...
  49. doi Differential expression of fibulins in the uterosacral ligaments of women with uterine prolapse
    Peter Takacs
    Department of Obstetrics and Gynecology, Jackson Memorial Hospital, University of Miami, Miami, FL 33010, USA
    Arch Gynecol Obstet 282:389-94. 2010
    To compare fibulin-3 (FIB-3) and fibulin-5 (FIB-5) expressions in uterosacral ligaments (USL) of women with and without uterine prolapse.
  50. doi MRI of the transverse and alar ligaments in rheumatoid arthritis: feasibility and relations to atlantoaxial subluxation and disease activity
    Nils Vetti
    Department of Radiology, Haukeland University Hospital, Bergen, 5021, Norway
    Neuroradiology 52:215-23. 2010
    Dysfunctional transverse and alar craniovertebral ligaments can cause instability and osseous destruction in rheumatoid arthritis (RA)...
  51. ncbi Differential elastin and tenascin immunolabeling in the uterosacral ligaments in postmenopausal women with and without pelvic organ prolapse
    Christian Goepel
    Department of Gynecology, Martin Luther University Halle Wittenberg, Ernst Grube Strabe 40, D O6097 Halle Saale, Germany
    Acta Histochem 110:204-9. 2008
    ..These data indicate a complex architecture of the extracellular matrix in the uterosacral ligaments, with marked differences in tenascin and elastin expression between postmenopausal women with or without POP.
  52. doi Ultrasonographic morphometric measurements of digital flexor tendons and ligaments of the palmar metacarpal region in Haflinger horses
    S Boehart
    Equine Clinic, Faculty of Veterinary Medicine, Freie Universitat Berlin, Oertzenweg 19b, 14163 Berlin, Germany
    Anat Histol Embryol 39:366-75. 2010
    ..Reference values for the tendons and ligaments in the palmar metacarpal region in sound Haflinger mares were obtained and the influence of different factors ..
  53. ncbi Comparison of structure, mechanical properties, and functions of lumbar spinal ligaments
    D W Hukins
    Department of Medical Biophysics, University of Manchester, England
    Spine (Phila Pa 1976) 15:787-95. 1990
    The organization of collagen in the supraspinous, interspinous, and longitudinal ligaments, as well as the ligamenta flava, in lumbar spines from human cadavers has been investigated by polarized light microscopy, scanning electron ..
  54. doi Biomechanical and histologic evaluation of tissue engineered ligaments using chitosan and hyaluronan hybrid polymer fibers: a rabbit medial collateral ligament reconstruction model
    Toru Irie
    Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Biomed Mater Res A 97:111-7. 2011
    ..At 3, 6, and 12 weeks after surgery, the failure loads of the engineered ligaments in the CSS groups were significantly greater than those in the NCSS groups...
  55. ncbi [Direct MR arthrography of the wrist- value in detecting complete and partial defects of intrinsic ligaments and the TFCC in comparison with arthroscopy]
    H Braun
    Institut für Röntgendiagnostik Universität Würzburg
    Rofo 175:1515-24. 2003
    ..arthroscopy for the evaluation of defects of the triangular fibrocartilage complex (TFCC) and intrinsic ligaments in patients with refractory wrist pain...
  56. ncbi Human ligaments classification: a new proposal
    G K Paraskevas
    Department of Anatomy, Medical School, Aristotle University of Thessaloniki, Greece
    Folia Morphol (Warsz) 70:61-7. 2011
    A high concern exists among physicians about surgically important ligaments such as cruciate and collateral ligaments of the knee, patellar ligament, tibiofibular syndesmosis, collateral ligaments of the ankle, and coracoclavicular ..
  57. ncbi Tissue-engineering approach to the repair and regeneration of tendons and ligaments
    James Cho Hong Goh
    Department of Orthopedic Surgery, National University of Singapore
    Tissue Eng 9:S31-44. 2003
  58. ncbi Uterine preservation or hysterectomy at sacrospinous colpopexy for uterovaginal prolapse?
    C F Maher
    Royal Women s and Mercy Hospital, Melbourne, Australia
    Int Urogynecol J Pelvic Floor Dysfunct 12:381-4; discussion 384-5. 2001
    ..01). The sacrospinous hysteropexy is effective in the treatment of uterine prolapse. Vaginal hysterectomy may not be necessary in the surgical treatment of uterine prolapse...
  59. ncbi Reconstruction of the coracoclavicular ligaments with tendon grafts: a comparative biomechanical study
    Steven J Lee
    Nicholas Institute of Sports Medicine and Athletic Trauma, Department of Orthopaedic Surgery, Lenox Hill Hospital The Cooper Union for the Advancement of Science and Art, New York, New York 10021, USA
    Am J Sports Med 31:648-55. 2003
    Numerous surgical techniques have been described to address injuries to the coracoclavicular ligaments.
  60. ncbi Stability of acromioclavicular joint reconstruction: biomechanical testing of various surgical techniques in a cadaveric model
    Ashwin V Deshmukh
    Department of Orthopaedics, Kaiser Permanente West Los Angeles Medical Center, Los Angeles, California, USA
    Am J Sports Med 32:1492-8. 2004
    ..The authors of this study sought to determine whether there is a biomechanical basis for this assertion and which augmentative method, if any, most closely restored acromioclavicular motion to normal...
  61. ncbi Modulation of proliferation and differentiation of human bone marrow stromal cells by fibroblast growth factor 2: potential implications for tissue engineering of tendons and ligaments
    Stefan Hankemeier
    Trauma Department, Hannover Medical School MHH, Hannover, Germany
    Tissue Eng 11:41-9. 2005
    ..For tissue engineering of ligaments and tendons, both stimulation of cell proliferation and differentiation with increased expression of essential ..
  62. ncbi Ligaments: a source of work-related musculoskeletal disorders
    M Solomonow
    Department of Orthopaedic Surgery, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Electromyogr Kinesiol 14:49-60. 2004
    The mechanical and neurological properties of ligaments are reviewed and updated with recent development from the perspective which evaluates their role as a source of neuromusculoskeletal disorders resulting from exposure to ..
  63. ncbi Interlaminar shear stresses and laminae separation in a disc. Finite element analysis of the L3-L4 motion segment subjected to axial compressive loads
    V K Goel
    Iowa Spine Research Center, Department of Biomedical Engineering and Orthopaedics, University of Iowa, USA
    Spine (Phila Pa 1976) 20:689-98. 1995
    ..Clinical relevance of the findings and possible relationship to the aging process are explored...
  64. pmc A hypothesis of chronic back pain: ligament subfailure injuries lead to muscle control dysfunction
    Manohar M Panjabi
    Biomechanics Research Laboratory, Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06520 8071, USA
    Eur Spine J 15:668-76. 2006
    ..A new hypothesis, based upon the concept that subfailure injuries of ligaments (spinal ligaments, disc annulus and facet capsules) may cause chronic back pain due to muscle control ..
  65. ncbi Autologous platelet concentrates as a treatment for musculoskeletal lesions in five horses
    D Arguelles
    Department of Animal Medicine and Surgery, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Spain
    Vet Rec 162:208-11. 2008
    ..All the horses had returned to their pre-injury level of performance by six months after the completion of the treatment, and none of them had suffered a recurrence after 20 months...
  66. ncbi Development of controlled matrix heterogeneity on a triphasic scaffold for orthopedic interface tissue engineering
    Jeffrey P Spalazzi
    Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Tissue Eng 12:3497-508. 2006
    ..The results of this study demonstrate the feasibility of multi-tissue regeneration on a single scaffold, and the potential of interface tissue engineering to enable the biological fixation of soft tissue grafts to bone...
  67. ncbi Differences in the presence of mechanoreceptors and nerve structures between wrist ligaments may imply differential roles in wrist stabilization
    Elisabet Hagert
    Karolinska Institutet, Department of Hand Surgery, Stockholm Soder Hospital, 118 83 Stockholm, Sweden
    J Orthop Res 23:757-63. 2005
    The purpose of this study was to analyze human wrist ligaments with regard to presence of general innervation and mechanoreceptors...
  68. ncbi Clear cell myomelanocytic tumor of the falciform ligament/ligamentum teres: a novel member of the perivascular epithelioid clear cell family of tumors with a predilection for children and young adults
    A L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Surg Pathol 24:1239-46. 2000
    ..The differential diagnosis of these tumors includes clear cell sarcoma of tendons and aponeuroses, leiomyosarcoma, and angiomyolipoma...
  69. ncbi [Changes of collagen content in uterine ligaments of perimenopausal women with relaxation of pelvic supports]
    Xin Luo
    Department of Obstetrics and Gynecology, People s Hospital of Wuhan University, Wuhan 430060, China
    Zhonghua Fu Chan Ke Za Zhi 43:422-4. 2008
    To investigate the changes in histological characteristics and collagen content in uterosacral and cardinal ligaments of perimenopausal women in relation to relaxation of pelvic supports.
  70. ncbi Age-dependent changes in matrix composition and organization at the ligament-to-bone insertion
    I Ning E Wang
    Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Ave, 351 Engineering Terrace Bldg, MC8904, New York, New York 10027, USA
    J Orthop Res 24:1745-55. 2006
    ..Marked differences in collagen fiber orientation between the femoral and tibial insertions were observed, and these differences became more pronounced with age...
  71. ncbi Aging of the elastic and collagen fibers in the human cervical interspinous ligaments
    Erika M K P Barros
    Institute of Orthopedics and Traumatology, University of Sao Paulo, Sao Paulo, Brazil
    Spine J 2:57-62. 2002
    The ligaments consist of collagen bands intermingled with elastic fibers that support hundreds of pounds of stress per square inch. In the spine the basic functional unit comprises vertebrae, intervertebral disc and ligament tissues...
  72. ncbi Tendons and ligaments are anatomically distinct but overlap in molecular and morphological features--a comparative study in an ovine model
    Adam P Rumian
    Department of Musculoskeletal Surgery, Imperial College, Charing Cross Hospital, London, W6 8RF, UK
    J Orthop Res 25:458-64. 2007
    Tendons and ligaments are similar in composition but differ in function. Simple anatomical definitions do not reflect the fact individual tendons and ligaments have unique properties due to their adaptation to a specific role...
  73. doi Magnetic resonance imaging of ligaments and membranes in the craniocervical junction in whiplash-associated injury and in healthy control subjects
    Reidar Dullerud
    Department of Neuroradiology, Ulleval University Hospital, Oslo, Norway
    Acta Radiol 51:207-12. 2010
    ..The pathogenesis and imaging findings in whiplash-associated injury (WAD) are poorly understood and remain debatable...
  74. ncbi Biomaterials and scaffolds for ligament tissue engineering
    Zigang Ge
    Department of Orthopedic Surgery, National University of Singapore, Singapore 119260
    J Biomed Mater Res A 77:639-52. 2006
    ..Although many studies have been done, progress for tissue-engineered anterior cruciate ligaments (ACLs) has been slow due to their complex structures and mechanical properties...
  75. ncbi The surgical approach to subaxial cervical spine injuries: an evidence-based algorithm based on the SLIC classification system
    Marcel F Dvorak
    Division of Spine, Department of Orthopaedics, University of British Columbia, Vancouver, Canada
    Spine (Phila Pa 1976) 32:2620-9. 2007
    ..Systematic review of literature and expert clinical opinions of the members of the Spine Trauma Study Group were combined to develop and refine this algorithm...
  76. ncbi A numerical approach to the study of spatial pattern formation in the ligaments of arcoid bivalves
    Anotida Madzvamuse
    Oxford University Computing Laboratory, Wolfson Building, Parks Road, Oxford OX1 3QD, UK
    Bull Math Biol 64:501-30. 2002
    ..employ the novel application of a reaction-diffusion model on a growing domain to examine growth patterns of the ligaments of arcoid bivalves (marine molluscs) using realistic growth functions...
  77. ncbi Posterior tibial tendon insufficiency: which ligaments are involved?
    Jonathan T Deland
    Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
    Foot Ankle Int 26:427-35. 2005
    ....
  78. doi The meniscofibular ligament: an MRI study
    Haron Obaid
    Department of Radiology, Doncaster Royal Infirmary, Doncaster DN2 5LT, UK
    Eur J Radiol 73:159-61. 2010
    ..To describe the appearances and determine the prevalence of the meniscofibular ligament (ligamentum fibulare-MFibL) on MRI of the knee...
  79. ncbi Whiplash-associated disorders impairment rating: neck disability index score according to severity of MRI findings of ligaments and membranes in the upper cervical spine
    Bertel Rune Kaale
    Firda Medical Center, PO Box 194, N 6821 Sandane, Norway
    J Neurotrauma 22:466-75. 2005
    ..Pre-selected structures for MRI assessment included the alar ligaments, the transverse ligament, the tectorial and the posterior atlanto-occipital membranes...
  80. ncbi Laparoscopic femoral hernia repair using umbilical ligament as plug
    Danagra Georgia Ikossi
    Department of Surgery, Stanford University, Stanford, California 94305 5733, USA
    J Laparoendosc Adv Surg Tech A 15:197-200. 2005
    ..The procedure is safe, simple, and provides excellent functional and cosmetic results...
  81. ncbi Laparoscopic uterosacral ligament uterine suspension compared with vaginal hysterectomy with vaginal vault suspension for uterovaginal prolapse
    Aparna Diwan
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Int Urogynecol J Pelvic Floor Dysfunct 17:79-83. 2006
    ..No LUSUS group patient underwent reoperation for recurrent apical prolapse as compared to three TVH patients. LUSUS is an effective treatment for appropriately selected women with uterovaginal prolapse who desire uterine preservation...
  82. ncbi Perioperative complications in abdominal sacrocolpopexy and vaginal sacrospinous ligament fixation procedures
    Fuat Demirci
    Department of Obstetrics and Gynecology, Duzce Medical Faculty, Abant Izzet Baysal University, Duzce, Turkey
    Int Urogynecol J Pelvic Floor Dysfunct 18:257-61. 2007
    ..In conclusion, abdominal sacrocolpopexy had a higher rate of perioperative complications and longer hospital stay and operating time...
  83. doi Regenerative medicine for tendinous and ligamentous injuries of sport horses
    Lisa A Fortier
    Department of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
    Vet Clin North Am Equine Pract 24:191-201. 2008
    ..Successful restoration processes for any tissue are thought to recapitulate those of development, in which there are spatial and temporal interactions between scaffold, growth factors, and cell populations...
  84. ncbi Posterior aspect of the orbital septum is reinforced by ligaments
    Hirohiko Kakizaki
    Department of Ophthalmology, Aichi Medical University, Aichi, Japan
    Jpn J Ophthalmol 49:477-80. 2005
    To investigate the ligaments reinforcing the posterior aspect of the orbital septum.
  85. ncbi Bilateral extraperitoneal uterosacral suspension: a new approach to correct posthysterectomy vaginal vault prolapse
    Peter L Dwyer
    Department of Urogynecology, Mercy Hospital for Women, 163 Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia
    Int Urogynecol J Pelvic Floor Dysfunct 19:283-92. 2008
    ..We believe this procedure to have less risk of ureteral injury than the intraperitoneal approach...
  86. ncbi Ischiorectal abscess after sacrospinous ligament suspension
    Michael Hibner
    Department of Obstetrics and Gynecology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Am J Obstet Gynecol 193:1740-2. 2005
    ..The abscess was diagnosed 9 months after the patient had a sacrospinous ligament suspension. She was treated successfully with perianal incision, drainage, and intravenous antibiotics...
  87. ncbi The location and contents of the lateral ligaments of the rectum: a study in human soft cadavers
    Rattaplee Pak-art
    Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Dis Colon Rectum 48:1941-4. 2005
    This study was designed to identify the location of the lateral ligaments of the rectum and to reveal its contents.
  88. ncbi Head position and impact direction in whiplash injuries: associations with MRI-verified lesions of ligaments and membranes in the upper cervical spine
    Bertel Rune Kaale
    Firda Medical Centre, Sandane, Norway
    J Neurotrauma 22:1294-302. 2005
    ..Focus was on MRI abnormalities of the alar and the transverse ligaments, and the tectorial and posterior atlanto-occipital membranes, graded 0-3...
  89. doi MRI of the alar and transverse ligaments in whiplash-associated disorders (WAD) grades 1-2: high-signal changes by age, gender, event and time since trauma
    Nils Vetti
    Department of Radiology, Haukeland University Hospital, Bergen, Norway
    Neuroradiology 51:227-35. 2009
    ..describes the prevalence of high-signal changes at magnetic resonance imaging (MRI) of the alar and transverse ligaments in whiplash-associated disorders (WAD) grades 1-2 in relation to age, gender, spinal degeneration, type of ..
  90. doi Urinary complications after surgery for posterior deep infiltrating endometriosis are related to the extent of dissection and to uterosacral ligaments resection
    Gil Dubernard
    Service de Gynecologie, obstétrique et médecine de la reproduction, Hopital Tenon, Universite Pierre et Marie Curie Paris VI, Assistance Publique des Hopitaux de Paris, France
    J Minim Invasive Gynecol 15:235-40. 2008
    ..The main locations of endometriosis were colorectum (58 patients), uterosacral ligaments (21 patients), and rectovaginal septum (7 patients)...
  91. ncbi Heterogeneity in anatomic outcome of sacrospinous ligament fixation for prolapse: a systematic review
    Daniel M Morgan
    Departments of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Obstet Gynecol 109:1424-33. 2007
    ..To explore why failure rates vary so much between published reports of sacrospinous ligament fixation to correct pelvic organ prolapse and what the potential sources of heterogeneity may be...
  92. ncbi Facet joint kinematics and injury mechanisms during simulated whiplash
    Adam M Pearson
    Biomechanics Research Laboratory, Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06520 8071, USA
    Spine (Phila Pa 1976) 29:390-7. 2004
    ..Facet joint kinematics and capsular ligament strains were evaluated during simulated whiplash of whole cervical spine specimens with muscle force replication...
  93. ncbi Skin ligaments: regional distribution and variation in morphology
    Lance G Nash
    Department of Anatomy and Structural Biology, School of Medicine, University of Otago, Dunedin, New Zealand
    Clin Anat 17:287-93. 2004
    Skin ligaments (SL) (L. retinacula cutis) are present extensively in the face, hands, feet, and in breast tissue, but have seldom been reported elsewhere in the body...
  94. ncbi The effects of refreezing on the viscoelastic and tensile properties of ligaments
    Daniel K Moon
    Musculoskeletal Research Center, Department of Bioengineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, USA
    J Biomech 39:1153-7. 2006
    Biomechanical testing protocols for ligaments can be extensive and span two or more days. During this time, a specimen may have to undergo more than one cycle of freezing and thawing...
  95. ncbi Magnetic resonance imaging assessment of craniovertebral ligaments and membranes after whiplash trauma
    Jostein Krakenes
    Department of Radiology, Haukeland University Hospital, and Department of Surgical Sciences, University of Bergen Medical School, Bergen, Norway
    Spine (Phila Pa 1976) 31:2820-6. 2006
    ..Review article...
  96. ncbi Tensile strength of spinal ligaments
    J B Myklebust
    Department of Neurosurgery, Medical College of Wisconsin, Milwaukee
    Spine (Phila Pa 1976) 13:526-31. 1988
    Spinal ligaments from 41 fresh human male cadavers were tested. The ligaments were tested in situ by sectioning all elements except the one under study...
  97. ncbi Subfailure damage in ligament: a structural and cellular evaluation
    Paolo P Provenzano
    Department of Biomedical Engineering and Department of Orthopedic Surgery, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
    J Appl Physiol 92:362-71. 2002
    Subfailure damage in ligaments was evaluated macroscopically from a structural perspective (referring to the entire ligament as a structure) and microscopically from a cellular perspective...
  98. ncbi Anatomicohistologic study of the retaining ligaments of the face and use in face lift: retaining ligament correction and SMAS plication
    Ragip Ozdemir
    Department of Plastic and Reconstructive Surgery, Ankara Numune Hospital, Ankara, Turkey
    Plast Reconstr Surg 110:1134-47; discussion 1148-9. 2002
    ..The retaining ligaments of the face support facial soft tissue in normal anatomic position, resisting gravitational change...
  99. ncbi Relationship of the dura, Hofmann's ligaments, Batson's plexus, and a fibrovascular membrane lying on the posterior surface of the vertebral bodies and attaching to the deep layer of the posterior longitudinal ligament. An anatomical, radiologic, and clin
    L L Wiltse
    Long Beach Memorial Medical Center, California
    Spine (Phila Pa 1976) 18:1030-43. 1993
    ..With MRI, hematomas can be differentiated from an extruded fragment. They may cause symptoms similar to an extruded disc but will probably heal with time.(ABSTRACT TRUNCATED AT 400 WORDS)..
  100. ncbi Falciform ligament abscess: report of a case
    Valdinaldo Aragão de Melo
    Department of Medicine, Federal University of Sergipe, Brazil
    Rev Hosp Clin Fac Med Sao Paulo 58:37-8. 2003
    ..The presence of right uppper quadrant abdominal pain, epigastric tenderness, fever, leukocytosis, and a mass in the anterior abdomen should arouse suspicion of falciform ligament abscess. Its treatment consists of abscess drainage...
  101. ncbi Intraoperatively proven anomalous Struthers' ligament diagnosed by MRI
    M Pecina
    Department of Orthopaedic Surgery, School of Medicine, University of Zagreb, Zagreb, Croatia
    Skeletal Radiol 31:532-5. 2002
    ..It produced symptoms identical to supracondylar process syndrome. Excision of the supracondylar process of the humerus and Struthers' ligament relieved symptoms in this athlete...

Research Grants66

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2013
    ..In the most severely affected, progression of this inflammatory process to the deeper periodontal ligaments and alveolar bone results in tooth loss from loss of mandibular anchorage...
  2. Novel Collagen II Alternative Transcripts and Mouse Skeletal Development
    Audrey McAlinden; Fiscal Year: 2010
    ..tissues such as the notochord, somitic mesoderm, fetal brain, spinal cord, developing eye, tendons and ligaments. Additional work on this project will investigate the mechanisms for regulating the amount of each alternatively ..
  3. Aligned Tendon or Ligament Derived Matrix Nanoscaffolds for Rotator Cuff Repair
    Dianne Little; Fiscal Year: 2013
    ..Research: The rotator cuff is a composite of joint capsule, tendons and ligaments that is critical for stability and function of the shoulder...
  4. Predicting cell deformation from body level mechanical loads
    Ahmet Erdemir; Fiscal Year: 2012
    ..Through multiscale mechanical coupling of these models, a map of cellular deformation in cartilage, ligaments and menisci under a variety of tibiofemoral joint loads will be obtained...
  5. Stress: Potential Impact on an Animal Model of Endometriosis
    Caroline B Appleyard; Fiscal Year: 2012
    ..glands and stroma outside the endometrial cavity, mainly in ovaries, fallopian tubes, cul-de-sac and the uterine ligaments. Theories of endometriosis suggest that its etiology arises from a complex interaction of both genetic and ..
  6. Processing and Preservation of Human Umbilical Cord Stem Cells for Cell Therapeut
    Alfred Bahnson; Fiscal Year: 2010
    ..have potential to be used for un-related donors to treat diseases related to cartilage, bone, muscle or tendons/ligaments. By maximizing the cell yield from each cord and developing techniques to store these cells for extended periods,..
  7. Phase-contrast enhanced X-ray imaging system for small joints of hand
    Thomas J Beck; Fiscal Year: 2010
    ..using synchrotron X-rays demonstrate that DPC can image with high resolution soft tissues such as cartilage and ligaments in the joints of the hand, knee and ankle...
  8. Genetic Determinants of Physiological Responses to Fluoride in Bone
    Eric T Everett; Fiscal Year: 2012
    ..Excessive systemic fluoride can result in calcification of soft tissues (e.g. ligaments), osteosclerosis, osteoporosis, and osteomalacia which can compromise bone quality and strength leading to ..
  9. Bilayered Vocal Fold Tissue Engineering
    Jennifer L Long; Fiscal Year: 2013
    ..The constructs are attached to the vocal ligaments of excised larynges simulating implantation conditions, and airflow-induced vibration is recorded with high-..
  10. Dual-Energy Cone-Beam Tomographic Imaging and Analysis for Rheumatoid Arthritis
    Jeffrey H Siewerdsen; Fiscal Year: 2013
    ..sub-millimeter spatial resolution and soft-tissue contrast including synovial tissues, cartilage, tendons, and ligaments through DE decomposition...
  11. Biomechanical Measurement and Modeling of Normal and Diseased Middle Ears
    Rong Z Gan; Fiscal Year: 2013
    ..provided by applicant): The middle ear, composed of ossicles and soft tissues including the tympanic membrane, ligaments, and joints plays a vital role in the transmission of sound and the sense of hearing...
  12. Patient-Specific Modeling of Total Knee Arthroplasty
    ROBERT ANTHONY SISTON; Fiscal Year: 2012
    ..on measurements made in cadaver specimens, or the simulations are heavily influenced by the properties of the ligaments that surround the knee, which are typically are modeled using archival data from the literature...
  13. Noninvasive Measurement Of Strain And Mechanical Properties In Tendons/Ligaments
    Ray Vanderby; Fiscal Year: 2010
    ..in order to non-invasively compute mechanical properties (nonlinear stiffness) and functional strains in ligaments and tendons. Mechanical properties can diagnose damage or a pathologic state (i.e...
  14. Collagen Diversity and Pathobiology in Skeletal Tissues
    David R Eyre; Fiscal Year: 2013
    ..forms the structural framework of all major skeletal tissues in the body including bone, cartilages, tendons and ligaments. Specifically, we aim to define the biochemical pathways that equip bone collagen to mineralize, cartilage to ..
  15. A Middle Ear Twist: Imaging, Physiology & Biomechanics
    RYAN PATRICK JACKSON; Fiscal Year: 2010
    ..At lower frequencies, the hinging mode is utilized due to the stiffness of the connecting ligaments and tendons...
  16. Inflammation and Cardiovascular Disease in RA
    Andreas H Hielscher; Fiscal Year: 2013
    ..progressive, systemic, inflammatory disease that primarily attacks peripheral joints and surrounding tendons and ligaments. This often very painful and debilitating disease affects approximately 1...
  17. Patient Oriented Research and Mentoring Program in Orthopedics
    Elena Losina; Fiscal Year: 2013
    ..of conditions with diverse etiologies that result in pain and functional impairment of bones, joints, tendons, ligaments and/or muscles...
  18. A Biomimetic Prehensile Digit for Upper-Limb Prostheses
    BRADLEY D VEATCH; Fiscal Year: 2011
    ..exploits properties and functional characteristics of synthetic textile fibers to replicate key functions of ligaments, tendons, and cartilaginous articulations within the anatomical finger, along with "bone" elements fabricated ..
  19. Combined Use of BMP-2 and Low Intensity Pulsed Ultrasound in Bone Regeneration
    AMARJIT SINGH VIRDI; Fiscal Year: 2010
    ..g., muscles, nerves, ligaments and tendons)...
  20. The In Vivo Biomechanics of Lateral Ankle Ligament Injury and Reconstruction
    Louis E DeFrate; Fiscal Year: 2010
    Sprains of the lateral ligaments of the ankle are one of the most common injuries in sports and recreation...
  21. Massage Therapy In Eccentric Exercise Induced Muscle Weakness And Inflammation
    THOMAS MICHAEL BEST; Fiscal Year: 2012
    ..on muscle include;relief of muscle tension and stiffness, faster healing of strained muscles and sprained ligaments, reduced muscle pain, swelling, and spasm, greater range of motion, and even enhanced athletic performance...
  22. Origins of Elasticity and Viscoelasticity in Ligaments
    Jeffrey A Weiss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ligaments are short bands of fibrous connective tissue that guide normal joint motion and restrict abnormal joint movement...
  23. Mechanical System for Low Force Fatigue Tissue Testing
    Dawn M Elliott; Fiscal Year: 2010
    ..In particular, mechanical properties of bone, cartilage, tendons, ligaments, intervertebral disc, muscle, and neural soft tissue samples are evaluated, and the effect on mechanical ..
  24. Genetic and chemical screening in zebrafish to study tendon development
    Jenna L Galloway; Fiscal Year: 2012
    ..provided by applicant): Tendons transmit force from the muscles to the bone, enabling movement, while ligaments connect bone to bone, providing stabilization...
  25. Quantitative UTE MR Imaging: Sensitive Biomarkers for Osteoarthritis
    Jiang Du; Fiscal Year: 2013
    ..A particular problem arises in MRI assessment because many joint tissues such as menisci, ligaments and tendons have T2s of only a few milliseconds...
  26. Cross-scale interactions between mineral and collagen for tendon-bone attachment
    Stavros Thomopoulos; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Torn tendons and ligaments often require surgical repair to their bony insertions. A large percentage of these repairs have poor outcomes;for example, up to 94% of surgical rotator cuff repairs fail...
  27. Genetic and chemical screening in zebrafish to study tendon development
    Jenna L Galloway; Fiscal Year: 2013
    Tendons transmit force from muscles to bone, enabling movement, wfiile ligaments connect bone to bone, providing stabilization...
  28. University of Michigan's TMJD and Orofacial Pain Interdisciplinary Consortium
    SUNIL D KAPILA; Fiscal Year: 2013
    ..TMJ pathogenesis;and (3) developmental biology, regeneration and tissue engineering of joint, muscle and ligaments. Where appropriate, embedded within each of these areas will be research and didactic experiences in ..
  29. Ligament engineering; Effect of gene induction and cyclic stretch
    ROBYN SHAFFER; Fiscal Year: 2010
    ..The studies outlined in this proposal will generate a platform for developing functional ligaments using a multidimensional approach involving polymeric biomaterial architecture and mechanical stretch as well as ..
  30. Modulation of the Immune System to Improve Ligament/Ligament Graft Healing
    Ray Vanderby; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Healing of ligaments after rupture and ligament grafts after reconstruction remains a great challenge...
  31. Transcriptional regulation of tendon differentiation and matrix formation
    Ronen Schweitzer; Fiscal Year: 2013
    ..to decipher the transcriptional network that governs collagen fibrillogenesis and fibril growth in tendons and ligaments. Identifying the key regulatory players in this process is likely to open new avenues for enhancement of the ..
  32. ELECTROSPINNING ARTIFICIAL LIGAMENTS AND TENDONS FOR POTENTIAL PROSTHESES
    JAVIER MACOSSAY-TORRES; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Over 800,000 injuries to ligaments, tendons and the joint capsule occur every year in the U.S.A...
  33. Development & Validation of Instrumented Synthetic Mechanical Analog Lumbar Spine
    JOHN ERIC JAMES; Fiscal Year: 2010
    ..lumbar spine (S1 - T12) that will consist of synthetic, normal or osteoporotic vertebrae, intervertebral discs, ligaments and facet joints...
  34. Ear Biomechanics for Restoration of Hearing
    RONG GAN; Fiscal Year: 2009
    ..and tympanometry;(2) to measure mechanical properties or viscoelasticity of middle ear tissues such as the ligaments and tympanic membrane;(3) to develop multi-field (i.e...
  35. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2002
    ..to weakness of the levator ani muscles which in turn results in marked stress placed on the uterosacral cardinal ligaments and endopelvic fascia, ultimately leading to secondary failure of the fascia and development of prolapse...
  36. "Recruitment of a Bone and Cancer Early Stage Investigator"
    D Rick Sumner; Fiscal Year: 2010
    ..translational researchers focusing on connective tissues, particularly bone, articular cartilage and tendons and ligaments. Two important strategic focus areas for the Medical Center include orthopedics and cancer, as evidenced by a ..
  37. MUSCULOSKELETAL STIFFNESS AND LOCOMOTION
    CLAIRE FARLEY; Fiscal Year: 2000
    Muscles, tendons, and ligaments have spring-like characteristics. Because these musculoskeletal elements change length when joints flex or extend, it is not surprising that joints exhibit spring-like characteristics...
  38. Advanced Detector for Biological Synchrotron Fiber Diffraction
    Thomas C Irving; Fiscal Year: 2010
    ..X-ray technologies to study the properties of biological tissues such as heart muscle, cartilage, tendons and ligaments as well as pathological structures involving protein mis-folding...
  39. KINEMATICS AND STABILITY OF THE ARCH OF THE FOOT
    Harold Kitaoka; Fiscal Year: 2001
    ..The arch is constrained by bony and articular geometry, ligaments, joint capsules, and fascia...
  40. Convergent Molecular Evolution of Moth and Spider Silks
    NADIA AYOUB; Fiscal Year: 2009
    ..These artificial silks can then be used in biomedical applications, such as artificial ligaments or tendons and incredibly thin but strong sutures.
  41. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2009
    ..Possible applications of spider silk range from artificial ligaments and tendons to bandages for burns to composite materials for multiple applications.
  42. Identification of Muscle-Derived Soluble and Mechanical Cues to Direct Differenti
    CATHERINE KYLEEN KUO; Fiscal Year: 2013
    ..mesenchymal stem cell-based strategies in regenerating new tissue to replace injured or diseased tendons and ligaments. The outcome of this research effort would significantly advance knowledge of tendon developmental biology, help ..
  43. In Situ Biomechanical Testing of the Anterior Vaginal Support System
    Yvonne Hsu; Fiscal Year: 2010
    ..room to measure the tensile behavior of anterior compartment apical support structures (uterosacral and cardinal ligaments)...
  44. Scalable Purification of Silk-Like Proteins from Transgenic Tobacco
    WILLIAM MARCOTTE; Fiscal Year: 2007
    ..This makes them desirable for biomedical applications such as artificial tendons and ligaments, cell scaffolds for bone and cartilage implants, and biodegradable micro-sutures...
  45. The Dorsal Wrist: Function in the Normal & Injured State
    Rita Patterson; Fiscal Year: 2007
    ..unreadable] [unreadable] The role of the specific components of the dorsal ligaments and the modes of failure that result in the different dynamic and static classifications of the clinical injury ..
  46. BIOLOGICAL ROLE OF LYSYL OXIDASE-2 IN MATRIX DEVELOPMENT
    Ian Hornstra; Fiscal Year: 1999
    ..of cross-linking collagen and elastin in the presence of molecular oxygen, producing the strong and flexible ligaments and tendons of large animal bodies...
  47. The Clinical Role of Wrist Joint Mechanoreceptors
    Richard Berger; Fiscal Year: 2004
    ..To identify mechanoreceptors in the key wrist ligaments, classify them according to morphology and develop a spatial reconstruction using computer aided three-..
  48. STABILIZING ROLE OF THE LIGAMENTS OF THE HUMAN ANKLE
    Sorin Siegler; Fiscal Year: 1990
    Traumatic injury of the ankle joint involving injury to the collateral ligaments is one of the most frequently occurring injuries at the lower limb. These injuries most frequently occur during a variety of athletic activities...
  49. Coupling Strategies for Middle Ear Protheses
    ANN GRONDA; Fiscal Year: 2003
    ..It will be used to obtain first-ever measures of compliance/damping characteristics of ossicular chain ligaments and joints in human temporal bones...
  50. Birth, Muscle Injury and Pelvic Floor Dysfunction
    John O L Delancey; Fiscal Year: 2013
    ..the interaction between birth-related levator muscle injury and the properties of the uterovaginal supporting ligaments associated with prolapse...
  51. CLINICAL BIOMECHANICS OF CERVICAL SPINE
    Manohar Panjabi; Fiscal Year: 1990
    ..and their measurements? What are the mechanisms of injuries in this region? What roles doe each of the spinal ligaments play in providing stability? What type and magnitude of instability leads to vertebral artery insufficiency? ..
  52. BONE GROWTH, PERIOSTEAL MIGRATION AND MUSCLE FUNCTION
    Susan Herring; Fiscal Year: 2007
    ..Although usually neglected, soft tissues such as muscles, ligaments and cartilages play a critical role in cranial mechanics and growth...
  53. A Novel Load Sensing Tibial Prosthesis Design
    DARRYL D LIMA; Fiscal Year: 2006
    ..of motion, complex articular surface topography, changing joint contact position, intra- and extra-articular ligaments, number of muscles crossing the knee joint and the presence of the patellofemoral joint contribute to the ..
  54. Mechanisms of Sub-rupture Local Tendon Damage and Repair
    NELLY A ANDARAWIS; Fiscal Year: 2011
    ..Studies have therefore evaluated mechanical and structural degeneration of ligaments and tendons in response to overuse and cyclic loading to investigate mechanism of initiation and progression of ..
  55. IN VIVO STRAIN MEASUREMENT OF RECONSTRUCTED AC LIGAMENT
    Robert Johnson; Fiscal Year: 1993
    ..will be compared with data previously obtained in vivo from a group of patients with normal anterior cruciate ligaments, and demonstrate our ability to restore normal kinematics to the knee joint at the time of RACL implantation...
  56. HUMAN AND MURINE MODELS OF TYPE V COLLAGEN DEFICIENCY
    Richard Wenstrup; Fiscal Year: 2003
    ..Therefore, the biomechanical integrity of some connective tissues including skin, tendon, and ligaments appears to be exquisitely sensitive to the quantity of pro-alpha1 (V) chains available to participate in ..
  57. Acupuncture and Low Back Pain during Pregnancy
    Shu Ming Wang; Fiscal Year: 2007
    ..GLBP is caused by enlargement of uterus, loosening of tendons and ligaments, and additional stress to the low back in pregnant women...
  58. Prolotherapy for the treatement of chronic lateral epicondylitis
    Ronald Glick; Fiscal Year: 2009
    ..Prolotherapy (PrT) involves the injection of an irritant or proliferant solution into tendons, ligaments, and joints to treat chronic musculoskeletal pain...
  59. MODULATION OF LOCAL BONE TISSUE MATERIAL PROPERTIES
    Clifford Les; Fiscal Year: 2004
    ..properties (strength and stiffness) that we believe helps to limit bending to those planes where muscles and ligaments have maximal mechanical influence...
  60. ROLE OF JOINT AFFERENTS IN KNEE MEDIO-LATERAL STABILITY
    YASIN DHAHER; Fiscal Year: 2001
    ..Reflex action may, in turn, be mediated either by muscle stretch receptors or by periarticular tissue afferents (ligaments and capsule)...
  61. EXERCISE & ELECTRICAL STIMULATION IN LIGAMENT INJURIES
    Laurence Dahners; Fiscal Year: 1990
    ..literature documents that immobilization has an adverse effect and mobilization a beneficial effect on uninjured ligaments and on the healing of injured ligaments...
  62. MECHANISMS OF CRUSTACEAN CARDIAC SUSPENSORY LIGAMENTS
    MALCOLM DEMONT; Fiscal Year: 1993
    ..the human heart, the elastic system of the lobster heart is physically separated, and consists of suspensory ligaments that function as tensile elastic elements...
  63. DEVELOPMENT OF A ROBOTICS-BASED SPINE TESTING SYSTEM
    Lars Gilbertson; Fiscal Year: 2003
    ..3) Determine the effects of degeneration and (4) surgery on in-situ forces of the disc, ligaments and facet joints...
  64. 37th Midwest Connective Tissue Workshop
    Susan Chubinskaya; Fiscal Year: 2009
    ..2) ECM MOLECULES: Proteoglycans, Hyaluronan, Collagen and Matrix proteins;3) CELLS and TISSUES: Bone, Cartilage, Ligaments, Tendons, Meniscus 4) New Investigator Short Talks...
  65. Electrochemically Guided Collagen Synthesis for Functional Tissue Engineering
    Ozan Akkus; Fiscal Year: 2009
    ..play a key role in creating strategies towards replacement of load bearing connective tissues such as tendons, ligaments, bones and vascular walls provided that the current study proves its feasibility...
  66. JOINT CONTRACTURE--BIOMEDICAL/CHEMICAL CORRELATES
    Wayne Akeson; Fiscal Year: 1990
    ..We have also observed profound differences in structure and composition of tendons as compared with ligaments, which lead us to the conclusion that more detailed analysis of individual structures is required with respect ..