intervertebral disk

Summary

Top Publications

  1. ncbi Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science
    Norbert Boos
    Orthopaedic University Hospital Balgrist, Zurich, Switzerland
    Spine (Phila Pa 1976) 27:2631-44. 2002
  2. ncbi Lumbar disc degeneration: epidemiology and genetics
    Michele C Battie
    Department of Physical Therapy, University of Alberta, 2 50 Corbett Hall, Edmonton, AB T6G 2G4, Canada
    J Bone Joint Surg Am 88:3-9. 2006
  3. ncbi A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration
    Koichi Masuda
    Department of Orthopedic Surgery, Rush Medical College, Chicago, Illinois 60612, USA
    Spine (Phila Pa 1976) 30:5-14. 2005
  4. pmc Complex loading affects intervertebral disc mechanics and biology
    B A Walter
    College of Engineering and Mathematical Sciences, University of Vermont, Burlington, VT, USA
    Osteoarthritis Cartilage 19:1011-8. 2011
  5. pmc Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile
    Christine Lyn Le Maitre
    Tissue Injury and Repair Group, School of Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Arthritis Res Ther 9:R77. 2007
  6. ncbi What is intervertebral disc degeneration, and what causes it?
    Michael A Adams
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 31:2151-61. 2006
  7. ncbi Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration
    Daisuke Sakai
    Department of Orthopaedic Surgery, Functional Reconstruction, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Biomaterials 24:3531-41. 2003
  8. ncbi The cell biology of intervertebral disc aging and degeneration
    Chang Qing Zhao
    Department of Orthopaedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092 Shanghai, China
    Ageing Res Rev 6:247-61. 2007
  9. ncbi The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain
    A J Freemont
    Tissue Injury and Repair Research Group, Research School of Clinical and Laboratory Sciences, University of Manchester, Manchester, UK
    Rheumatology (Oxford) 48:5-10. 2009
  10. ncbi Results of the prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement versus circumferential fusion for the treatment of 1-level degenerative disc disease
    Jack Zigler
    Texas Back Institute Texas Health Research Institute, Plano, TX 75093, USA
    Spine (Phila Pa 1976) 32:1155-62; discussion 1163. 2007

Detail Information

Publications387 found, 100 shown here

  1. ncbi Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science
    Norbert Boos
    Orthopaedic University Hospital Balgrist, Zurich, Switzerland
    Spine (Phila Pa 1976) 27:2631-44. 2002
    ..A histologic study on age-related changes of the human lumbar intervertebral disc was conducted...
  2. ncbi Lumbar disc degeneration: epidemiology and genetics
    Michele C Battie
    Department of Physical Therapy, University of Alberta, 2 50 Corbett Hall, Edmonton, AB T6G 2G4, Canada
    J Bone Joint Surg Am 88:3-9. 2006
    ..The extreme variations in prevalence rates are likely largely due to inconsistencies in the definitions and measurements of disc degeneration. Such inconsistencies and inaccuracies impede epidemiologic research on disc degeneration...
  3. ncbi A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration
    Koichi Masuda
    Department of Orthopedic Surgery, Rush Medical College, Chicago, Illinois 60612, USA
    Spine (Phila Pa 1976) 30:5-14. 2005
    ..OBJECTIVE.: To establish a reproducible rabbit model of disc degeneration by puncturing the anulus with needles of defined gauges and to compare it to the classic stab model...
  4. pmc Complex loading affects intervertebral disc mechanics and biology
    B A Walter
    College of Engineering and Mathematical Sciences, University of Vermont, Burlington, VT, USA
    Osteoarthritis Cartilage 19:1011-8. 2011
    ..Few studies have examined the interacting biologic and structural alterations associated with potentially injurious complex loading, which may be an important contributor to chronic progressive degeneration...
  5. pmc Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile
    Christine Lyn Le Maitre
    Tissue Injury and Repair Group, School of Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Arthritis Res Ther 9:R77. 2007
    ..The data thus suggest that although both cytokines may be involved in the pathogenesis of IVD degeneration, IL-1 may have a more significant role than TNFalpha, and thus may be a better target for therapeutic intervention...
  6. ncbi What is intervertebral disc degeneration, and what causes it?
    Michael A Adams
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 31:2151-61. 2006
    ..Review and reinterpretation of existing literature...
  7. ncbi Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration
    Daisuke Sakai
    Department of Orthopaedic Surgery, Functional Reconstruction, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Biomaterials 24:3531-41. 2003
    ..This study strengthens the viable efficacy of practical application of MSCs in treatment of intervertebral disc disease...
  8. ncbi The cell biology of intervertebral disc aging and degeneration
    Chang Qing Zhao
    Department of Orthopaedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092 Shanghai, China
    Ageing Res Rev 6:247-61. 2007
    ..Moreover, a very early intervention is indicated by the finding that the onset of human disc degeneration occurs as early as by adolescence...
  9. ncbi The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain
    A J Freemont
    Tissue Injury and Repair Research Group, Research School of Clinical and Laboratory Sciences, University of Manchester, Manchester, UK
    Rheumatology (Oxford) 48:5-10. 2009
    ....
  10. ncbi Results of the prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement versus circumferential fusion for the treatment of 1-level degenerative disc disease
    Jack Zigler
    Texas Back Institute Texas Health Research Institute, Plano, TX 75093, USA
    Spine (Phila Pa 1976) 32:1155-62; discussion 1163. 2007
    ..A prospective, randomized, multicenter, Food and Drug Administration-regulated Investigational Device Exemption clinical trial...
  11. ncbi Fas ligand exists on intervertebral disc cells: a potential molecular mechanism for immune privilege of the disc
    Toru Takada
    Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Spine (Phila Pa 1976) 27:1526-30. 2002
    ..Rat and human intervertebral disc specimens were examined immunohistochemically. Reverse transcription polymerase chain reaction (RT-PCR) analysis was also performed on rat disc tissue to demonstrate the existence of Fas ligand...
  12. ncbi Cells from different regions of the intervertebral disc: effect of culture system on matrix expression and cell phenotype
    Heather A Horner
    Physiology Laboratory, Oxford University, Oxford, and the Centre for Spinal Studies, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
    Spine (Phila Pa 1976) 27:1018-28. 2002
    ..This study examined how the culture system and region of cellular origin affect disc cell morphology and extracellular matrix production...
  13. ncbi Lumbar disc disorders and low-back pain: socioeconomic factors and consequences
    Jeffrey N Katz
    Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Bone Joint Surg Am 88:21-4. 2006
    ..These methodologic challenges notwithstanding, the toll of lumbar disc disorders is enormous, underscoring the critical importance of identifying strategies to prevent these disorders and their consequences...
  14. ncbi New in vivo measurements of pressures in the intervertebral disc in daily life
    H J Wilke
    Abteilung für kräftigungstherapie und Rehabilitation, Schmerzklinik Kirschgarten, Basel, Switzerland
    Spine (Phila Pa 1976) 24:755-62. 1999
    ..We conducted intradiscal pressure measurements with one volunteer performing various activities normally found in daily life, sports, and spinal therapy...
  15. pmc Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells
    Rosalyn Delia Abbott
    School of Engineering and Department of Orthopaedics and Rehabilitation, University of Vermont, Burlington, Vermont 05405, USA
    J Orthop Res 30:482-8. 2012
    ..Additional studies to optimize NC culture conditions are required to determine if NC conditioned medium can be made with the capacity to enhance NP cell proliferation and metabolism...
  16. ncbi Expression of Fas ligand and apoptosis of disc cells in herniated lumbar disc tissue
    J B Park
    Department of Orthopaedic Surgery, Uijongbu St Mary s Hospital, The Catholic University of Korea, Kyunggi Do
    Spine (Phila Pa 1976) 26:618-21. 2001
    ..An examination of surgically obtained herniated lumbar disc tissues performed by using immunohistochemical staining and the DNA nick end labeling method...
  17. ncbi 15. Discogenic low back pain
    Jan Willem Kallewaard
    Department of Anesthesiology and Pain Management, Alysis Rijnstate Hospital, Arnhem, The Netherlands
    Pain Pract 10:560-79. 2010
    ..It is advised that ozone discolysis, nucleoplasty, and targeted disc decompression should only be performed as part of a study protocol. Future studies should include more strict inclusion criteria...
  18. ncbi Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases
    J D Kang
    Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pennsylvania, USA
    Spine (Phila Pa 1976) 22:1065-73. 1997
    ..Endogenously produced nitric oxide appears to have a strong inhibitory effect on the production of interleukin-6, which suggests that autocrine mechanisms play an important role in the regulation of disc cell metabolism...
  19. pmc Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation
    Kyung Suk Choi
    Department of Molecular Genetics, University of Florida, College of Medicine, Gainesville, Florida 32610, USA
    Dev Dyn 237:3953-8. 2008
    ..In addition, the identification of notochordal remnants in mice is the first step towards generating an in vivo model of chordoma...
  20. ncbi Intervertebral disc: anatomy-physiology-pathophysiology-treatment
    P Prithvi Raj
    Department of Anesthesiology and Pain Management, Texas Tech University, Lubbock, Texas, USA
    Pain Pract 8:18-44. 2008
    ..The rationale for new therapies are to substitute the biochemical constituents, or augment nucleus pulposus or regenerate cartilaginous end-plate or finally artificial disc implantation....
  21. pmc Degeneration of the intervertebral disc
    Jill P G Urban
    University Laboratory of Physiology, Oxford University, Oxford, UK
    Arthritis Res Ther 5:120-30. 2003
    ..New developments, such as genetic and biological approaches, may allow better diagnosis and treatments in the future...
  22. ncbi Nutrition of the intervertebral disc
    Jill P G Urban
    Physiology Laboratory, Oxford University, Oxford, United Kingdom
    Spine (Phila Pa 1976) 29:2700-9. 2004
    ..A review of the literature on disc nutrition...
  23. ncbi Aging and degeneration of the human intervertebral disc
    J A Buckwalter
    Department of Orthopaedics, University of Iowa, Iowa City, USA
    Spine (Phila Pa 1976) 20:1307-14. 1995
    ....
  24. ncbi Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators
    J G Burke
    University College Dublin, The Mater Misericordiae Hospital, Ireland
    J Bone Joint Surg Br 84:196-201. 2002
    ....
  25. ncbi Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls
    H E Gruber
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, North Carolina, USA
    Spine (Phila Pa 1976) 23:751-7. 1998
    ..The authors of this study analyzed immunohistochemical distributions of Types I, II, III and VI collagen, in situ localization of apoptotic disc cells, and tartrate-resistant acid phosphatase localization...
  26. ncbi Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals
    Kenneth M C Cheung
    Department of Orthopaedics and Traumatology, University of Hong Kong, Hong Kong, China
    Spine (Phila Pa 1976) 34:934-40. 2009
    ..A cross-sectional population study of magnetic resonance imaging (MRI) changes. OBJECTIVE.: To examine the pattern and prevalence of lumbar spine MRI changes within a southern Chinese population and their relationship with back pain...
  27. ncbi Low back pain in relation to lumbar disc degeneration
    K Luoma
    Finnish Institute of Occupational Health, Helsinki, Finland
    Spine (Phila Pa 1976) 25:487-92. 2000
    ..Cross-sectional magnetic resonance imaging (MRI) study...
  28. ncbi A prospective, randomized, multicenter Food and Drug Administration investigational device exemptions study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: part I: evaluation of clinical outcomes
    Scott Blumenthal
    Texas Back Institute, Plano, Texas 75093, USA
    Spine (Phila Pa 1976) 30:1565-75; discussion E387-91. 2005
    ..A prospective, randomized, multicenter, Food and Drug Administration-regulated Investigational Device Exemption clinical trial...
  29. pmc BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Bone Miner Res 25:1179-90. 2010
    ..It is concluded that by controlling both GAG and aggrecan synthesis, these growth factors positively influence disk cell function...
  30. ncbi Disc chondrocyte transplantation in a canine model: a treatment for degenerated or damaged intervertebral disc
    Timothy Ganey
    Atlanta Medical Center, Atlanta, Georgia 30312, USA
    Spine (Phila Pa 1976) 28:2609-20. 2003
    ..A dog model was used to investigate the hypothesis that autologous disc chondrocytes can be used to repair damaged intervertebral disc...
  31. pmc The relationship between facet joint osteoarthritis and disc degeneration of the lumbar spine: an MRI study
    A Fujiwara
    Department of Orthopaedic Surgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Eur Spine J 8:396-401. 1999
    ....
  32. pmc Effect of nutrient deprivation on the viability of intervertebral disc cells
    S R S Bibby
    Physiology Laboratory, Oxford University, Parks Road, Oxford OX1 3PT, UK
    Eur Spine J 13:695-701. 2004
    ..These results indicate that the combined nutrient and metabolite environment, rather than concentrations of any single nutrient, should be considered when studying cellular physiology in the disc...
  33. ncbi Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc
    Amit Agrawal
    Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Arthritis Rheum 58:3798-808. 2008
    ....
  34. ncbi Correlation between T2 relaxation time and intervertebral disk degeneration
    Hiroyuki Takashima
    Department of Orthopedic Surgery, School of Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Skeletal Radiol 41:163-7. 2012
    ..The goal of the present study was to use T2 mapping to quantify intervertebral disk water content according to the Pfirrmann classification.
  35. pmc The effects of dynamic loading on the intervertebral disc
    Samantha C W Chan
    ARTORG Center for Biomedical Engineering, Spine Research Center, Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014 Bern, Switzerland
    Eur Spine J 20:1796-812. 2011
    ..In addition, the parameter space of 'physiological' loading may also be an important factor for the differentiation of stem cells towards most ideally 'discogenic' cells for tissue engineering purpose...
  36. pmc Simulated-physiological loading conditions preserve biological and mechanical properties of caprine lumbar intervertebral discs in ex vivo culture
    Cornelis P L Paul
    Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 7:e33147. 2012
    ..The characterization of caprine IVD response to culture in the LDCS under SPL conditions paves the way for controlled analysis of degeneration- and regeneration-associated processes in the future...
  37. ncbi Expression of the Trp2 allele of COL9A2 is associated with alterations in the mechanical properties of human intervertebral discs
    Darwesh M K Aladin
    Department of Orthopaedics and Traumatology, University of Hong Kong, Hong Kong, China
    Spine (Phila Pa 1976) 32:2820-6. 2007
    ..Biomechanical study into the association between genetic polymorphism in COL9A2 and mechanical properties of human nucleus pulposus...
  38. pmc Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc
    Chitra Lekha Dahia
    Division of Orthopaedic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    PLoS ONE 7:e35944. 2012
    ....
  39. ncbi An in vitro organ culturing system for intervertebral disc explants with vertebral endplates: a feasibility study with ovine caudal discs
    Benjamin Gantenbein
    AO Research Institute, Davos, Switzerland
    Spine (Phila Pa 1976) 31:2665-73. 2006
    ..Whole ovine caudal intervertebral discs with vertebral endplates were cultured under uniaxial diurnal loading for 7 days...
  40. pmc Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs
    Kyung Suk Choi
    Department of Molecular Genetics and Microbiology and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 108:9484-9. 2011
    ..As notochord cells form nuclei pulposi, we propose that the notochord sheath functions as a "wrapper" around the notochord to constrain these cells along the vertebral column...
  41. ncbi Relationship of Modic type 1 change with disc degeneration: a prospective MRI study
    Katariina Luoma
    Helsinki and Uudenmaa District University Hospitals, Helsinki University Central Hospital, HUS röntgen, PL 340, 00029 HUS, Helsinki, Finland
    Skeletal Radiol 38:237-44. 2009
    ..The objective was to study the natural course of Modic type 1 change (M1) in relation to lumbar disc degeneration...
  42. ncbi Upregulation of the viability of nucleus pulposus cells by bone marrow-derived stromal cells: significance of direct cell-to-cell contact in coculture system
    Yukihiro Yamamoto
    Department of Orthopaedic Surgery, Tokai University School of Medicine, Kanagawa, Japan
    Spine (Phila Pa 1976) 29:1508-14. 2004
    ..Upregulation of the viability of nucleus pulposus cells by coculture with bone marrow-derived stromal cells using a novel culture system...
  43. ncbi Postnatal growth, differentiation, and aging of the mouse intervertebral disc
    Chitra Lekha Dahia
    Division of Orthopaedic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati OH 45229, USA
    Spine (Phila Pa 1976) 34:447-55. 2009
    ..OBJECTIVE.: To initiate use of the mouse as a model system for postnatal IVD differentiation and growth, and to serve as a basis for assaying changes caused by disease or genetic or experimental perturbation...
  44. ncbi A systematic review of mechanical lumbar disc decompression with nucleoplasty
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 12:561-72. 2009
    ..There is a paucity of evidence for all decompression techniques, specifically alternative techniques including nucleoplasty...
  45. ncbi Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression
    Gwendolyn Sowa
    Departments of Orthopaedic Surgery and daggerPhysical Medicine and Rehabilitation, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Spine (Phila Pa 1976) 33:1821-8. 2008
    ..A cohort of young, healthy New Zealand White rabbits was followed longitudinally with serial magnetic resonance imaging (MRI) analysis and terminal analysis of histologic changes and gene expression...
  46. ncbi Analysis of cell viability in intervertebral disc: Effect of endplate permeability on cell population
    A Shirazi-Adl
    Department of Mechanical Engineering, Ecole Polytechnique, P O Box 6079, Station Centre Ville, Montreal, Quebec, Canada H3C 3A7
    J Biomech 43:1330-6. 2010
    ....
  47. pmc Future perspectives of cell-based therapy for intervertebral disc disease
    Daisuke Sakai
    Department of Orthopaedic Surgery, Surgical Science and Research Center for Regenerative Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa, 259 1193, Japan
    Eur Spine J 17:452-8. 2008
    ..Future perspectives for cell-based therapies for intervertebral disc disease are also discussed...
  48. ncbi ISSLS prize winner: A study of diffusion in human lumbar discs: a serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs
    S Rajasekaran
    Department of Orthopaedics and Spine Surgery, Ganga Hospital, Coimbatore, India
    Spine (Phila Pa 1976) 29:2654-67. 2004
    ..An in vivo serial magnetic resonance imaging study of diffusion characteristics in human lumbar discs over 24 hours in healthy volunteers and patients with low back pain...
  49. ncbi 2001 Volvo Award Winner in Basic Science Studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc
    H A Horner
    Physiology Laboratory, Oxford University, Parks Road, Oxford OX1 3PT, England, United Kingdom
    Spine (Phila Pa 1976) 26:2543-9. 2001
    ..Disc cell viability was analyzed in relation to nutrient supply and cellular demand in vitro in a diffusion chamber...
  50. pmc Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison
    Christopher J Hunter
    McCaig Centre for Joint Injury and Arthritis Research, Canada
    J Anat 205:357-62. 2004
    ..The present study examines several different species commonly used in lumbar spine investigations to explore the variability of notochordal cells in the IVD...
  51. ncbi Prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: five-year follow-up
    Richard D Guyer
    Texas Back Institute, 6020 West Parker Road, Suite 200, Plano, TX 75093, USA
    Spine J 9:374-86. 2009
    ..No long-term, randomized, prospective study on the CHARITE disc or any other artificial disc has been published to date...
  52. ncbi Matrix synthesis and degradation in human intervertebral disc degeneration
    C L Le Maitre
    Tissue Injury and Repair Group, School of Medicine, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Biochem Soc Trans 35:652-5. 2007
    ..Inhibition of IL-1 would therefore be an important therapeutic target for preventing/reversing disc degeneration...
  53. ncbi Transplantation of mesenchymal stem cells in a canine disc degeneration model
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259 1193, Japan
    J Orthop Res 26:589-600. 2008
    ..The results of this study suggest that MSC transplantation may contribute to the maintenance of IVD immune privilege by the differentiation of transplanted MSCs into cells expressing FasL...
  54. pmc Are animal models useful for studying human disc disorders/degeneration?
    Mauro Alini
    AO Research Institute, Clavadelerstrasse, 7270, Davos, Switzerland
    Eur Spine J 17:2-19. 2008
    ....
  55. ncbi The notochordal cell in the nucleus pulposus: a review in the context of tissue engineering
    C J Hunter
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Calgary, AB, Canada
    Tissue Eng 9:667-77. 2003
    ..During embryogenesis of the intervertebral disk, the cells of the notochord play a critical role in initiating tissue formation, and may be responsible for ..
  56. ncbi Modified Pfirrmann grading system for lumbar intervertebral disc degeneration
    James F Griffith
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Spine (Phila Pa 1976) 32:E708-12. 2007
    ..A reliability study was conducted. OBJECTIVE.: To modify a grading system for lumbar disc degeneration and to test the reliability of this modified grading system...
  57. ncbi Mechanical conditions that accelerate intervertebral disc degeneration: overload versus immobilization
    Ian A F Stokes
    Department of Orthopaedics and Rehabilitation, University of Vermont, Burlington, Vermont 05405, USA
    Spine (Phila Pa 1976) 29:2724-32. 2004
    ..A review of the literature on macromechanical factors that accelerate disc degeneration with particular focus on distinguishing the roles of immobilization and overloading...
  58. ncbi A prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: part II: evaluation of radiographic outcomes and correlation
    Paul C McAfee
    Spine and Scoliosis Center, St Joseph s Hospital, Baltimore, Maryland, USA
    Spine (Phila Pa 1976) 30:1576-83; discussion E388-90. 2005
    ..A prospective, randomized, multicenter, Food and Drug Administration-regulated, investigational device exemption clinical trial...
  59. pmc Total disc replacement surgery for symptomatic degenerative lumbar disc disease: a systematic review of the literature
    Karin D van den Eerenbeemt
    Department of Orthopaedics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur Spine J 19:1262-80. 2010
    ..High quality randomized controlled trials with relevant control group and long-term follow-up is needed to evaluate the effectiveness and safety of TDR...
  60. ncbi 1995 Volvo Award in clinical sciences. The diagnostic accuracy of magnetic resonance imaging, work perception, and psychosocial factors in identifying symptomatic disc herniations
    N Boos
    Department of Orthopaedic Surgery, Inselspital, Switzerland
    Spine (Phila Pa 1976) 20:2613-25. 1995
    ..The only highly significant difference between the study group and control group regarding morphologic fi..
  61. ncbi The Twin Spine Study: contributions to a changing view of disc degeneration
    Michele C Battie
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada
    Spine J 9:47-59. 2009
    ..The Twin Spine Study, a research program on the etiology and pathogenesis of disc degeneration, has contributed to a substantial revision of this view of determinants of lumbar disc degeneration...
  62. ncbi Influence of a follower load on intradiscal pressure and intersegmental rotation of the lumbar spine
    A Rohlmann
    Biomechanics Laboratory, Orthopaedic Hospital of the Free University of Berlin, Germany
    Spine (Phila Pa 1976) 26:E557-61. 2001
    ..CONCLUSIONS: A superimposed follower load renders spinal loading with pure moments more physiologic...
  63. ncbi Recent advances in disc cell biology
    Helen E Gruber
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, North Carolina 28232, USA
    Spine (Phila Pa 1976) 28:186-93. 2003
    ..There have been many advances over the past decade in understanding and experimentally modulating biologic aspects of intervertebral disc cell function. An overview of the current state of this biologic research is presented...
  64. ncbi Papain-induced in vitro disc degeneration model for the study of injectable nucleus pulposus therapy
    Samantha C W Chan
    Tissue and Organ Mechanobiology, Institute of Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
    Spine J 13:273-83. 2013
    ..Proteolytic enzyme digestion of the intervertebral disc (IVD) offers a method to simulate a condition of disc degeneration for the study of cell-scaffold constructs in the degenerated disc...
  65. ncbi A three-year follow-up of lumbar spine endplate (Modic) changes
    Mari Kuisma
    Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
    Spine (Phila Pa 1976) 31:1714-8. 2006
    ..A longitudinal follow-up of Modic changes on magnetic resonance imaging (MRI)...
  66. ncbi Biphasic scaffold for annulus fibrosus tissue regeneration
    Yuqing Wan
    Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Biomaterials 29:643-52. 2008
    ..The excellent mechanical properties and biocompatibility of the BMG/PPCLM scaffold make it a promising candidate for AF repair...
  67. ncbi Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment
    Makarand V Risbud
    Department of Orthopaedic Surgery and Graduate Program in Tissue Engineering and Regenerative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107
    J Cell Biochem 98:152-9. 2006
    ..The study confirmed that HIF-1alpha can be used as a phenotypic marker of nucleus pulposus cells...
  68. ncbi Notochordal cells stimulate migration of cartilage end plate chondrocytes of the intervertebral disc in in vitro cell migration assays
    Ki Won Kim
    Department of Orthopedic Surgery, St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    Spine J 9:323-9. 2009
    ..In addition, the effect of notochordal cells on this property has not been elucidated...
  69. ncbi Molecular pathogenic factors in symptomatic disc degeneration
    D Greg Anderson
    Department of Orthopaedics, Thomas Jefferson University, Rothman Institute, 925 Chestnut Street, Philadelphia, PA 19107, USA
    Spine J 5:260S-266S. 2005
    ..Although symptomatic disc degeneration is thought to be the leading cause of chronic low back pain, no available biologic therapy is yet available to treat this highly prevalent condition...
  70. ncbi Fas-ligand expression on nucleus pulposus begins in developing embryo
    Yoshihiro Inui
    Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Spine (Phila Pa 1976) 29:2365-9. 2004
    ..The expression of Fas ligand in the notochord or nucleus pulposus was examined immunohistochemically using rat embryos...
  71. ncbi Atherosclerosis and disc degeneration/low-back pain--a systematic review
    L I Kauppila
    Terveystalo Healthcare, Helsinki, Finland
    Eur J Vasc Endovasc Surg 37:661-70. 2009
    ..The diminished blood flow could result in various back problems. The aim of this systematic literature review was to assess associations between atherosclerosis and disc degeneration (DD) or low-back pain (LBP)...
  72. ncbi Recent advances in biological therapies for disc degeneration: tissue engineering of the annulus fibrosus, nucleus pulposus and whole intervertebral discs
    Katherine D Hudson
    Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States
    Curr Opin Biotechnol 24:872-9. 2013
    ..The few in vivo studies show promise in retaining disc height and MRI T2 signal intensity, the gold standard in determining disc health...
  73. ncbi Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration
    Cheryle A Séguin
    BioEngineering of Skeletal Tissues Team, University of Toronto, Ontario, Canada
    Matrix Biol 25:409-18. 2006
    ..Depletion of tissue proteoglycans was mediated by ERK and NF-kappaB-dependent "aggrecanase" activity, suggesting MT1-MMP and ADAMTS-4 and -5 as effectors of TNFalpha-induced tissue catabolism...
  74. ncbi Biaxial mechanics and inter-lamellar shearing of stem-cell seeded electrospun angle-ply laminates for annulus fibrosus tissue engineering
    Tristan P Driscoll
    McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Orthop Res 31:864-70. 2013
    The annulus fibrosus (AF) of the intervertebral disk plays a critical role in vertebral load transmission that is heavily dependent on the microscale structure and composition of the tissue...
  75. ncbi Rheological characterization of hyaluronic acid derivatives as injectable materials toward nucleus pulposus regeneration
    Antonio Gloria
    Institute of Composite and Biomedical Materials, National Research Council, P le Tecchio 80, 80125, Naples, Italy
    J Biomater Appl 26:745-59. 2012
    ..Both HA derivatives showed a 'gel-like' rheological behavior similar to the native NP tissue and this behavior was not altered by injection...
  76. ncbi Interobserver and intraobserver variability in interpretation of lumbar disc abnormalities. A comparison of two nomenclatures
    M N Brant Zawadzki
    Hoag Memorial Hospital, Newport Beach, California, USA
    Spine (Phila Pa 1976) 20:1257-63; discussion 1264. 1995
    ..CONCLUSIONS. Experienced readers using standardized nomenclature showed moderate to substantial agreement with interpreting disc extension beyond the interspace on magnetic resonance imaging...
  77. pmc Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord
    Makarand V Risbud
    Department of Orthopedic Surgery and Graduate Program in Tissue Engineering and Regenerative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Dev Dyn 239:2141-8. 2010
    ..Thus, the most critical choice for a suitable animal model should relate more to the anatomical and mechanical characteristics of the motion segment than concerns of cell loss and replacement by non-notochordal cells...
  78. ncbi An injectable vehicle for nucleus pulposus cell-based therapy
    Estelle C Collin
    Network of Excellence for Functional Biomaterials, MDRG and NFB Building, National University of Ireland, Galway NUIG, IDA Business Park, Newcastle Rd, Galway, Ireland
    Biomaterials 32:2862-70. 2011
    ..05). The optimally stabilised and functionalised type II collagen/HA hydrogel system developed in this study shows promise as an injectable reservoir system for intervertebral disc regeneration...
  79. ncbi Immunohistochemical study of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 human intervertebral discs
    M Kanemoto
    Department of Orthopaedic Surgery, Shiga University of Medical Science, Japan
    Spine (Phila Pa 1976) 21:1-8. 1996
    ....
  80. ncbi Calcification in human intervertebral disc degeneration and scoliosis
    Gergana I Hristova
    SMBD Jewish General Hospital, Lady Davis Institute for Medical Research, 3755 Cote Ste Catherine Road, Montreal, Canada H3T 1E2 QC
    J Orthop Res 29:1888-95. 2011
    ..The results suggest that disc degeneration in adults is associated with ongoing mineral deposition and that mineralization in AIS discs might reflect a premature degenerative process...
  81. ncbi The effects of cyclic tensile strain on the organisation and expression of cytoskeletal elements in bovine intervertebral disc cells: an in vitro study
    S Li
    Arthritis Research UK Biomechanics and Bioengineering Centre, School of Biosciences, Cardiff University, UK
    Eur Cell Mater 21:508-22. 2011
    ..Differential mechano-regulation of anabolic and catabolic ECM components in the OAF and NP populations reflects their respective mechanical environments in situ...
  82. pmc HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc
    Nobuyuki Fujita
    Department of Orthopaedic Surgery and Graduate Program in Cell and Developmental Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Bone Miner Res 27:401-12. 2012
    ..These results for the first time provide a rationale for the normoxic stabilization as well as the maintenance of steady-state levels of HIF-1α and HIF-2α in nucleus pulposus cells...
  83. ncbi Intervertebral disk degeneration and emerging biologic treatments
    Christopher K Kepler
    Department of Orthopedic Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
    J Am Acad Orthop Surg 19:543-53. 2011
    Although understanding of the biologic basis of intervertebral disk (IVD) degeneration is rapidly advancing, the unique IVD environment presents challenges to the development and delivery of biologic treatments...
  84. ncbi Intervertebral disc repair using adipose tissue-derived stem and regenerative cells: experiments in a canine model
    Timothy Ganey
    Department of Orthopaedic Surgery, Atlanta Medical Center, Atlanta, GA 30312, USA
    Spine (Phila Pa 1976) 34:2297-304. 2009
    ..Therapeutic treatment of intervertebral disc repair using cells...
  85. ncbi Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration
    James Melrose
    Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, The Royal North Shore Hospital of Sydney, St Leonards, New South Wales, Australia
    Spine (Phila Pa 1976) 37:18-25. 2012
    ....
  86. ncbi Differential phenotype of intervertebral disc cells: microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus
    Daisuke Sakai
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Spine (Phila Pa 1976) 34:1448-56. 2009
    ..Microarray gene expression profiling, quantitative gene expression analysis, and immunohistochemistry was used to investigate molecular variations between nucleus pulposus (NP) and anulus fibrosus (AF) of the dog intervertebral disc (IVD)...
  87. ncbi Correlation of matrix metalloproteinases-1 and -3 with patient age and grade of lumbar disc herniation
    Andreas Zigouris
    Department of Neurosurgery, University Hospital of Ioannina, Greece
    J Neurosurg Spine 14:268-72. 2011
    ..The authors studied the histological alterations and the expression of matrix metalloproteinase (MMP)-1 and MMP-3 in disc specimens of patients who had undergone operations for lumbar disc herniation...
  88. ncbi Human nucleus pulposus cells react to IL-6: independent actions and amplification of response to IL-1 and TNF-α
    Rebecca K Studer
    VA Pittsburgh, Pittsburgh, PA, USA
    Spine (Phila Pa 1976) 36:593-9. 2011
    ..CONCLUSION.: The results suggest maneuvers to diminish IL-6 production in the disc could provide some protection against the adverse effects of IL-1 and TNF-α, thus, helping preserve disc composition, structure, and function...
  89. pmc Disc height reduction in adjacent segments and clinical outcome 10 years after lumbar 360 degrees fusion
    Tobias L Schulte
    Department of Orthopaedics, University Hospital Munster, Albert Schweitzer Strasse 33, 48149, Munster, Germany
    Eur Spine J 16:2152-8. 2007
    ..This may be induced by additional biomechanical stress, ongoing degeneration affecting the lumbar spine and advancing age. However, clinical outcome is not correlated with adjacent DHR...
  90. ncbi Notochordal cell produce and assemble extracellular matrix in a distinct manner, which may be responsible for the maintenance of healthy nucleus pulposus
    Rodolfo Cappello
    Royal Veterinary College, University of London, London, UK
    Spine (Phila Pa 1976) 31:873-82; discussion 883. 2006
    ..Analysis of proteoglycan synthesis, distribution and assembly of notochordal cells and small nucleus pulposus cells embedded in alginate beads and cultured in presence of [S]-Na2SO4...
  91. pmc Characteristics and natural course of vertebral endplate signal (Modic) changes in the Danish general population
    Tue S Jensen
    The Back Research Center, Ringe, Denmark
    BMC Musculoskelet Disord 10:81. 2009
    ....
  92. ncbi A prospective cohort study of close interval computed tomography and magnetic resonance imaging after primary lumbar discectomy: factors associated with recurrent disc herniation and disc height loss
    Matthew J McGirt
    Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Spine (Phila Pa 1976) 34:2044-51. 2009
    ..Prospective cohort study...
  93. pmc In vivo 3.0-tesla magnetic resonance T1rho and T2 relaxation mapping in subjects with intervertebral disc degeneration and clinical symptoms
    Gabrielle Blumenkrantz
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 63:1193-200. 2010
    ..This study suggests that T(1rho) may be sensitive to early degenerative changes (corroborating previous studies) and clinical symptoms in intervertebral disc degeneration...
  94. ncbi Lumbar disc high-intensity zone. Correlation of magnetic resonance imaging and discography
    K P Schellhas
    Center for Diagnostic Imaging, St Louis Park, Minnesota, USA
    Spine (Phila Pa 1976) 21:79-86. 1996
    ..Only one high-intensity zone was found in the control subjects. CONCLUSIONS: In patients with symptomatic low back pain, the high-intensity zone is a reliable marker of painful outer anular disruption...
  95. ncbi Atlas-based segmentation of degenerated lumbar intervertebral discs from MR images of the spine
    Sofia K Michopoulou
    Department of Medical Physics and Bioengineering, University College London, London WC1E 6BT, U K
    IEEE Trans Biomed Eng 56:2225-31. 2009
    ..Moreover, this approach could be exploited in computer-assisted spine surgery...
  96. pmc Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells
    Mostafa A Gabr
    Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Orthop Res 29:1-7. 2011
    ..IL-17 may be an important regulator of inflammation in the IVD pathologies...
  97. ncbi Identification of cell proliferation zones, progenitor cells and a potential stem cell niche in the intervertebral disc region: a study in four species
    Helena Henriksson
    Department of Clinical Chemistry and Transfusion Medicine, The Institute of Biomedicine, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    Spine (Phila Pa 1976) 34:2278-87. 2009
    ..Descriptive experimental study in 4 different mammals...
  98. ncbi Familial predisposition for lumbar degenerative disc disease. A case-control study
    H Matsui
    Department of Orthopaedic Surgery, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Japan
    Spine (Phila Pa 1976) 23:1029-34. 1998
    ..There may be a genetic factor in the development of lumbar disc herniation as an expression of disc degeneration...
  99. ncbi Changes in nuclear composition following cyclic compression of the intervertebral disc in an in vivo rat-tail model
    Congo T S Ching
    Jockey Club Rehabilitation Engineering Centre, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, PR China
    Med Eng Phys 26:587-94. 2004
    ..Further studies are required to verify this, but the choice of control appears to need careful consideration in all studies of this nature...
  100. ncbi Load-sharing between anterior and posterior elements in a lumbar motion segment implanted with an artificial disc
    A P Dooris
    Iowa Spine Research Center, Departments of Biomedical Engineering andOrthopaedics, University of Iowa, Iowa City, Iowa, USA
    Spine (Phila Pa 1976) 26:E122-9. 2001
    ....
  101. ncbi Effect of aging and degeneration on disc volume and shape: A quantitative study in asymptomatic volunteers
    Christian W A Pfirrmann
    Department of Radiology, Orthopedic University Hospital, Balgrist, Switzerland
    J Orthop Res 24:1086-94. 2006
    ..In the absence of disc degeneration, however, age tends to result in an inverse relationship on disc height, volume, and shape...

Research Grants64

  1. MECHANICAL STIMULATION OF IVD CELLS
    Lori A Setton; Fiscal Year: 2013
    ....
  2. Image-based modeling of nonlinear and anisotropic intervertebral disc mechanics
    Edward J Vresilovic; Fiscal Year: 2010
    ..5 postdoctoral researchers, 0.2 technicians) and University of Minnesota (1 graduate student, 0.5 postdoctoral researchers). ..
  3. Self-assembling Biomimetic Hydrogels with Bioadhesive Properties for Intervertebr
    ANDREA JENNIFER VERNENGO; Fiscal Year: 2013
    ....
  4. Collagen Diversity and Pathobiology in Skeletal Tissues
    David R Eyre; Fiscal Year: 2013
    ..With this knowledge new targets for therapy and prevention of genetic and acquired human disorders of bones and joints are predicted. ..
  5. Developing Immature Nucleus Pulposus Cells for Regenerative Therapy
    Jun Chen; Fiscal Year: 2013
    ....
  6. Imaging NFkB Activity in Relation to Animal Behavior in Peripheral Neuropathy
    ROBERT D BOWLES; Fiscal Year: 2013
    ..The applicant will obtain broader training in research methodology, animal models, grant and manuscript preparation and responsible conduct in research that will prepare him for an academic career in bioengineering. ..
  7. Training and research application for c-spine ultrasound of an aging population.
    DANIEL BUCKLAND; Fiscal Year: 2013
    ....
  8. PATHOGENESIS OF DISEASE IN MUCOPOLYSACCHARIDOSIS I AND VII
    Katherine P Ponder; Fiscal Year: 2010
    ..These studies may demonstrate that the development of disease in the aorta and the cervical spine in MPS is due to a common mechanism, and may identify a therapy for these difficult-to-treat sites. ..
  9. Mechanobiology in CAM: Differential Effects of Amplitude
    ROBERT ALLEN HARTMAN; Fiscal Year: 2013
    ..abstract_text> ..
  10. The role of cellular senescence in intervertebral disc aging
    Nam V Vo; Fiscal Year: 2013
    ....
  11. Noninvasive measurement of intervertebral disc mechanics with MR Elastography
    Alexander C Wright; Fiscal Year: 2012
    ..abstract_text> ..
  12. Stem cells from the intervertebral disc: do they vary in degeneration?
    Zulma Gazit; Fiscal Year: 2010
    ..It is our hypothesis that stem cells residing in the degenerated nucleus pulposus demonstrate a change in their number and/or differentiation profile compared to SCs in healthy discs. ..
  13. Role of CCN2 and CCN3 in aging and degeneration of the intervertebral disc
    Cassie M Tran; Fiscal Year: 2013
    ..The information provided by the proposed study will provide insight into the role of CTGF and CCN3 in the aging nucleus pulposus. ..
  14. Mechanical System for Low Force Fatigue Tissue Testing
    Dawn M Elliott; Fiscal Year: 2010
    ..Jointly, these three sites employ 136 manufacturing positions and 160 service personnel who will immediately benefit from the sale of an ElectroPuls system by the preservation and/or creation of jobs. ..
  15. Novel Oral Therapy For the Mucopolysaccharidoses
    CALOGERA MARIA SIMONARO; Fiscal Year: 2013
    ..PPS could represent the first oral medication for MPS, and if these experiments are successful could have a very high and immediate impact on the treatment and management of patients with these disorders. ..
  16. Novel Biomaterials as Sealants for Applications in Annulus Fibrosus Repair
    Clare Canal Guterl; Fiscal Year: 2012
    ....
  17. Endplate permeability and spinal disc degeneration
    JEFFREY CHARLES LOTZ; Fiscal Year: 2010
    ..These data will be important to clarify the role of compromised nutrition in disc degeneration, and to specify whether endplate permeability modification is necessary to augment successful tissue engineering approaches for disc repair. ..
  18. PET/MRI Imaging of Neuraxial Inflammation in Sciatica Patients
    Yi Zhang; Fiscal Year: 2013
    ..Among the main causes of sciatica pain are intervertebral disk displacement and stenosis of the intervertebral foramen producing inflammation of neural structures and ..
  19. Alternative treatments for disc degeneration: Effects on matrix homeostasis
    Gwendolyn A Sowa; Fiscal Year: 2013
    ..The goals of this research are to understand the effects of motion based therapies, such as yoga, and oral supplements, including glusosamine, chondroitin, and omega-3 fatty acids, on the cartilage of the spine. ..
  20. Regeneration of Nucleus Pulposus by Tissue Engineering
    Irving M Shapiro; Fiscal Year: 2013
    ..The goal of the proposal is to understand the mechanism that controls the fate and function of these progenitor cells in both the normal and diseased intervertebral disc. ..
  21. Simvastatin to Retard Degenerative Disc Disease
    Chia Ying Lin; Fiscal Year: 2013
    ..It is then proposed in this study to observe the potential to inject simvastatin into degenerative disc to retard the progression of degenerative disc disease and also help repair the aberrant tissues. ..
  22. Biphasic Intervertebral Disc Regeneration using Biomimetic Scaffolds
    Benjamin R Whatley; Fiscal Year: 2012
    ..Scaffolds will first be created with immobilized signaling molecules followed by implantation and histological evaluation in subcutaneous rodent models. ..
  23. Role of matrix shear stress in annulus fibrosus cell mechanobiology
    Adam H Hsieh; Fiscal Year: 2012
    ..Results of this project will provide detailed insight into the effects of mechanical shear stresses on cell function. Such knowledge can aid the development of regenerative strategies against disorders such as degenerative disc disease. ..
  24. Mechansims and Clinical Importance of Hyperkyphosis:The Framingham Study
    ELIZABETH SAMELSON; Fiscal Year: 2013
    ....
  25. Hydrogels for hMSC delivery &engraftment
    Andres J Garcia; Fiscal Year: 2013
    ..Finally, because of the transformative potential of MSC, this research will have broad significance and impact to many regenerative medicine applications. ..
  26. 2011 Cartilage Biology &Pathology GRC
    Karen M Lyons; Fiscal Year: 2011
    ..The conference has consistently been rated as "outstanding" by the participants. The format remains unchanged from our previous highly successful conferences, with ample time for informal discussions. ..
  27. Formation of the intervertebral disk: a molecular approach
    BRIAN DAVID HARFE; Fiscal Year: 2012
    ..a year are spent on the treatment of back pain and there are presently no cures for a damaged/degenerating intervertebral disk. The center region of the intervertebral disk is composed of a soft, highly hydrated tissue called the ..
  28. Functional Notochordal Cell Interactions to Prevent and Repair Disc Degeneration
    James C Iatridis; Fiscal Year: 2010
    ..Clinical relevance involves determination of target molecules for pharmaceutical use on mature disc cells and on MSCs to prevent degenerative changes and promote cell therapy repair techniques. ..
  29. Strain-Dependent Glucose Transport and Metabolism in Intervertebral Disc
    ALICIA RENEE JACKSON; Fiscal Year: 2010
    ..The outcome of these studies will provide insight into the etiological causes of disc degeneration and LBP and may also be used in the development of new strategies for treatment of LBP. ..
  30. MECHANISM OF DISC PROTEOGLYCAN LOSS IN A MOUSE MODEL OF ACCELERATED AGING
    Nam V Vo; Fiscal Year: 2011
    ....
  31. Development of optimal sodium-MRI methodology for the musculoskeletal field.
    Jae Seung Lee; Fiscal Year: 2013
    ..In addition, optimal detection schemes will be designed for faster scan times, and finally, to translate the developed methods to clinical practice, thereby making sodium MRI a readily available diagnostic tool. ..
  32. Notochordal Cell Derived Therapies for Painful Disc Degeneration
    James C Iatridis; Fiscal Year: 2013
    ..Innovation and significance are also high because determining optimal microenvironmental culturing conditions of NCs will help accelerate the growing body of research on these underexplored cells. ..
  33. TGF-beta in the pathology and development of the spine.
    Rosa A Serra; Fiscal Year: 2013
    ..The experiments described here will characterize the earliest stages of IVD development and provide information necessary for future efforts to developmentally engineer IVD. ..
  34. Decellularized Stem Cell Matrix Rejuvenates Human Cells from Herniated Discs
    Ming Pei; Fiscal Year: 2013
    ..Our long-term goal is to develop an autologous disc cell-based minimally invasive therapeutic approach toward physiological reconstruction of a biologically functional disc in a clinical setting. ..
  35. An injectable biocompatible hydrogel nucleus pulposus replacement
    Gavin Braithwaite; Fiscal Year: 2009
    ....
  36. The genetic basis of disc disease
    BRIAN DAVID HARFE; Fiscal Year: 2013
    ..The proposed innovative screen is risky but has the potential to generate more knowledge about the molecular components involved in forming and maintaining disc structure than the entire field has generated in the last 50 years. ..
  37. Low Back Pain: A Multi-Center Clinical Trial
    James N Weinstein; Fiscal Year: 2013
    ..Long-term follow-up in these unique cohorts is crucial to assess long-term outcomes and cost-effectiveness. ..
  38. An Improved Atomic Force Microscope for Biomedical Applications: Deep AFM for lar
    Paul K Hansma; Fiscal Year: 2013
    ..This work will be synergistic with our ongoing collaboration with physicians on diagnosing bone fragility due to bone tissue degeneration in patients. ..
  39. PROGRAM PROJECT GRANT
    Gunnar B Andersson; Fiscal Year: 2010
    ..This Program Project will result in major progress that will directly translate into relief for so many individuals suffering from low back pain that is associated with intervertebral disc and facet joint degeneration. ..
  40. Role of HIF-1 in Intervertebral Disc Function
    Makarand V Risbud; Fiscal Year: 2013
    ..Outcomes from these studies will lead to the development of new pharmacological interventions aimed at maintaining the structural integrity of the disc and mitigating the inflammatory response. ..
  41. Mechanical Injury and Repair in the Intervertebral Disc
    James C Iatridis; Fiscal Year: 2013
    ..The chronic experiments will evaluate how changes in the message levels and enzyme activation/inhibition may lead to alterations in protein content and disc structure. ..
  42. Treatment of disc degeneration by nano-fullerenes
    XUDONG JOSHUA LI; Fiscal Year: 2012
    ....
  43. UTE MR Imaging of the Cartilaginous Endplate in the Lumbar Spine
    Won C Bae; Fiscal Year: 2013
    ..This is likely to be useful for early intervention in treatment of disc degeneration and selection of patients suitable for biological therapy. ..
  44. Cell Therapy for the degenerating intervertebral discs
    YEJIA NONE ZHANG; Fiscal Year: 2010
    ..Thomas Jefferson University provides a rich environment, and has a strong commitment to support her career development. ..
  45. Model of Human Disc Regeneration in the spectrum of Degenerative Disc Disease
    James C Iatridis; Fiscal Year: 2013
    ....
  46. BACK PAIN OUTCOME ASSESSMENT TEAM
    Richard Deyo; Fiscal Year: 1991
    ..Guidelines for use of these services will ge disseminated by professional and payer organizations and innovative CME efforts. New decision aids for both physicians and patients will incorporate data from all the assessment activities...
  47. Age-related changes in the intervertebral disk.
    BRIAN DAVID HARFE; Fiscal Year: 2011
    ..5 million people a year becoming disabled. The center region of the intervertebral disk is composed of soft, highly hydrated tissue called the nucleus pulposus...
  48. Immunity to versican and ankylosing spondylitis
    Yiping Zhang; Fiscal Year: 2007
    ..We also intend to identify the role of HLA-B27 in the pathogenesis of the VGI/model using human HLA-B*2705 transgenic animals. ..
  49. Engineered Multi-Functional Nanofibrous Meniscus Implants
    John Esterhai; Fiscal Year: 2009
    ..of millions of patients afflicted with debilitating joint pathology and degeneration due to trauma or disease, and may be extended for application in other dense fibrous tissues such as tendons and ligaments and the intervertebral disk.
  50. New Horizons in Intervertebral Disc Research
    Irving M Shapiro; Fiscal Year: 2013
    ..The conference organizers expect broad participation from basic researchers as well as clinicians concerned with diagnosis and treatment of spinal disorders. ..
  51. Phenotypes of pathologic vertebral endplate degeneration
    Jeffrey C Lotz; Fiscal Year: 2013
    ..Future studies will focus on clarifying mechanisms for the innervated disc pathologies that are linked to symptoms in patients. ..
  52. Structured co-culture of stem cells and chondrocytes for spinal disc repair
    Jeffrey C Lotz; Fiscal Year: 2013
    ..In Aim 3 we will determine whether optimized BCPs lead to morphologically-relevant improvements (as compared to appropriate control conditions) within a small animal model of disc injury. ..
  53. BIOELASTIC MATERIAL TO PREVENT POST-LAMINECTOMY ADHESION
    Jie Xu; Fiscal Year: 2001
    ..S. Development of materials that would improve the outcome of intervertebral disc laminectomy would clearly be of commercial significance while impacting favorably on medical care costs. ..
  54. TYPE III COLLAGEN GENE EXPRESSION IN CARTILAGE
    SHERRILL ADAMS; Fiscal Year: 2007
    ..type III collagen is found in adult articular cartilages and in the cartilage-like structures of the intervertebral disk. The amount of type III collagen is increased significantly in osteoarthritis and degenerative disk disease,..
  55. BIOELASTIC MATERIALS FOR INTERVERTEBRAL DISC RESTORATION
    Asima Pattanaik; Fiscal Year: 1999
    ..S. Development of materials to restore diseased intervertebral discs would be of commercial significance and would impact favorably on medical care costs. ..
  56. AGING AND FUNCTIONAL OUTCOME AFTER SURGERY FOR SDM
    Neil Oldridge; Fiscal Year: 1990
    ....
  57. TISSUE ENGINEERING OF THE INTERVERTEBRAL DISC
    J VRESILOVIC; Fiscal Year: 2002
    ....
  58. MUTATIONS CAUSING DISC DISEASE AND SCIATICA
    Leena Ala Kokko; Fiscal Year: 2003
    ..4) To do genome-wide screen on 100 affected sib pairs and/or families to identify additional loci for intervertebral disc disease. ..
  59. TISSUE ENGINEERING OF THE INTERVERTEBRAL DISC
    J VRESILOVIC; Fiscal Year: 2001
    ....
  60. Development of Hydrogel Spinal Disc Replacement
    Barbara Boyan; Fiscal Year: 2004
    ..abstract_text> ..
  61. Intervertebral Disc Response to Cyclic Loading in Vivo
    CLARK HUNG; Fiscal Year: 2005
    ..abstract_text> ..
  62. Causes and Consequences of Hyperkyphosis in Older Women
    Deborah Kado; Fiscal Year: 2007
    ..This cost-effective and innovative use of an existing data set is likely to produce the first systematic analyses of this common condition. ..
  63. THE PRIMARY CILIUM OF CONECTIVE TISSUE CELLS: INCIDENCE AND ORIENTATION
    Cornelia Farnum; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  64. Clinical Decision Making in Low Back Pain
    Jon Lurie; Fiscal Year: 2006
    ..To develop decision analytic models for specific patient subgroups, which also accommodate individual patient preference and quality of life data, for the purpose of identifying optimal treatment strategies. ..