hair follicle

Summary

Summary: A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.

Top Publications

  1. pmc Defining the epithelial stem cell niche in skin
    Tudorita Tumbar
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10021, USA
    Science 303:359-63. 2004
  2. ncbi Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 118:635-48. 2004
  3. ncbi Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
    R Dasgupta
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    Development 126:4557-68. 1999
  4. ncbi A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages
    S Müller-Röver
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg, Germany
    J Invest Dermatol 117:3-15. 2001
  5. ncbi beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13092, Berlin, Germany
    Cell 105:533-45. 2001
  6. ncbi Controls of hair follicle cycling
    K S Stenn
    Beauty Genome Sciences Inc, Skillman, New Jersey, USA
    Physiol Rev 81:449-494. 2001
  7. pmc Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
    Valerie Horsley
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 126:597-609. 2006
  8. ncbi Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
    Mayumi Ito
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, M8 Stellar Chance Building, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Med 11:1351-4. 2005
  9. ncbi Lgr5 marks cycling, yet long-lived, hair follicle stem cells
    Viljar Jaks
    Karolinska Institutet, Department of Biosciences and Nutrition, Novum, SE 141 57 Huddinge, Sweden
    Nat Genet 40:1291-9. 2008
  10. ncbi Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
    Rui Yi
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nat Genet 38:356-62. 2006

Research Grants

Detail Information

Publications264 found, 100 shown here

  1. pmc Defining the epithelial stem cell niche in skin
    Tudorita Tumbar
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10021, USA
    Science 303:359-63. 2004
    ..Many of the >100 messenger RNAs preferentially expressed in the niche encode surface receptors and secreted proteins, enabling LRCs to signal and respond to their environment...
  2. ncbi Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 118:635-48. 2004
    In adult skin, each hair follicle contains a reservoir of stem cells (the bulge), which can be mobilized to regenerate the new follicle with each hair cycle and to reepithelialize epidermis during wound repair...
  3. ncbi Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
    R Dasgupta
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    Development 126:4557-68. 1999
    ..To probe the role of activated LEF/TCF transcription factor complexes in hair follicle morphogenesis and differentiation, we engineered mice harboring TOPGAL, a beta -galactosidase gene under the ..
  4. ncbi A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages
    S Müller-Röver
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg, Germany
    J Invest Dermatol 117:3-15. 2001
    Numerous strains of mice with defined mutations display pronounced abnormalities of hair follicle cycling, even in the absence of overt alterations of the skin and hair phenotype; however, in order to recognize even subtle, hair cycle-..
  5. ncbi beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13092, Berlin, Germany
    Cell 105:533-45. 2001
    ..Further analysis demonstrates that beta-catenin is essential for fate decisions of skin stem cells: in the absence of beta-catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate...
  6. ncbi Controls of hair follicle cycling
    K S Stenn
    Beauty Genome Sciences Inc, Skillman, New Jersey, USA
    Physiol Rev 81:449-494. 2001
    ..In this review we have used Chase as our model and tried to put the adult hair follicle growth cycle in perspective...
  7. pmc Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
    Valerie Horsley
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 126:597-609. 2006
    ..lineage commitment occurs when multipotent stem cells are specified to three lineages: the epidermis, the hair follicle, and the sebaceous gland (SG). How and when a lineage becomes specified remains unknown...
  8. ncbi Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
    Mayumi Ito
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, M8 Stellar Chance Building, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Med 11:1351-4. 2005
    The discovery of long-lived epithelial stem cells in the bulge region of the hair follicle led to the hypothesis that epidermal renewal and epidermal repair after wounding both depend on these cells...
  9. ncbi Lgr5 marks cycling, yet long-lived, hair follicle stem cells
    Viljar Jaks
    Karolinska Institutet, Department of Biosciences and Nutrition, Novum, SE 141 57 Huddinge, Sweden
    Nat Genet 40:1291-9. 2008
    ..multipotent stem cell population able to give rise to new hair follicles and maintain all cell lineages of the hair follicle over long periods of time...
  10. ncbi Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
    Rui Yi
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nat Genet 38:356-62. 2006
    ..Here we characterize miRNAs in skin, the existence of which was hitherto unappreciated, and demonstrate their differential expression and importance in the morphogenesis of epithelial tissues within this vital organ...
  11. ncbi De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
    U Gat
    Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Cell 95:605-14. 1998
    ..Our findings suggest that transient beta-catenin stabilization may be a key player in the long-sought epidermal signal leading to hair development and implicate aberrant beta-catenin activation in hair tumors...
  12. ncbi Capturing and profiling adult hair follicle stem cells
    Rebecca J Morris
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Biotechnol 22:411-7. 2004
    The hair follicle bulge possesses putative epithelial stem cells. Characterization of these cells has been hampered by the inability to target bulge cells genetically...
  13. pmc Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis
    Kim B Jensen
    Laboratory for Epidermal Stem Cell Biology, Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
    Cell Stem Cell 4:427-39. 2009
    ..We show that, in mouse epidermis, Lrig1 defines the hair follicle junctional zone adjacent to the sebaceous glands and infundibulum...
  14. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    b>Hair follicle morphogenesis is initiated by a dermal signal that induces the development of placodes in the overlying epithelium...
  15. ncbi Melanin pigmentation in mammalian skin and its hormonal regulation
    Andrzej Slominski
    Dept of Pathology, Suite 599, University of Tennessee Health Science Center, 930 Madison Avenue, Memphis, TN 38163, USA
    Physiol Rev 84:1155-228. 2004
    ..Indeed, the significance of melanogenesis extends beyond the mere assignment of a color trait...
  16. pmc Scratching the surface of skin development
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA
    Nature 445:834-42. 2007
    ..Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for use in the natural cycles of hair follicle regeneration and for re-epithelialization in response to wounding.
  17. pmc Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling
    Eric Festa
    Department of Molecular Biology, Yale University, 219 Prospect St, New Haven, CT 06520, USA
    Cell 146:761-71. 2011
    ..These data highlight adipogenic cells as skin niche cells that positively regulate skin stem cell activity, and suggest that adipocyte lineage cells may alter epithelial stem cell function clinically...
  18. pmc Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration
    Piul Rabbani
    Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    Cell 145:941-55. 2011
    Melanocyte stem cells (McSCs) intimately interact with epithelial stem cells (EpSCs) in the hair follicle bulge and secondary hair germ (sHG). Together, they undergo activation and differentiation to regenerate pigmented hair...
  19. pmc beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair
    David Enshell-Seijffers
    Cutaneous Biology Research Center, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
    Dev Cell 18:633-42. 2010
    The activity of keratinocytes in the hair follicle is regulated by signals from a specialized mesenchymal niche, the dermal papilla (DP)...
  20. ncbi Molecular mechanisms regulating hair follicle development
    Sarah E Millar
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 118:216-25. 2002
    ..The importance of the hair follicle in skin biology, however, does not rest solely with its ability to produce hair...
  21. pmc SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells
    Jeffrey Biernaskie
    Hospital for Sick Children, University of Toronto, ON, Canada
    Cell Stem Cell 5:610-23. 2009
    ..We show that SKPs derive from Sox2(+) hair follicle dermal cells and that these two cell populations are similar with regard to their transcriptome and functional ..
  22. pmc GATA-3: an unexpected regulator of cell lineage determination in skin
    Charles K Kaufman
    Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 17:2108-22. 2003
    Multipotent skin stem cells give rise to epidermis and its appendages, including the hair follicle. The Lef-1/Tcf family of Wnt-regulated transcription factors plays a major role in specification of the hair shaft, but little is known ..
  23. pmc Hair follicle stem cells are specified and function in early skin morphogenesis
    Jonathan A Nowak
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 3:33-43. 2008
    In adult skin, epithelial hair follicle stem cells (SCs) reside in a quiescent niche and are essential for cyclic bouts of hair growth. Niche architecture becomes pronounced postnatally at the start of the first hair cycle...
  24. pmc Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells
    Isaac Brownell
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Cell Stem Cell 8:552-65. 2011
    In adult skin, stem cells in the hair follicle bulge cyclically regenerate the follicle, whereas a distinct stem cell population maintains the epidermis. The degree to which all bulge cells have equal regenerative potential is not known...
  25. ncbi Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle
    L Karlsson
    Department of Medical Biochemistry, Goteborg University, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:2611-21. 1999
    ..Platelet-derived growth factor-A (PDGF-A) is expressed in the developing epidermis and hair follicle epithelium, and its receptor PDGF-Ralpha is expressed in associated mesenchymal structures...
  26. pmc Review of hair follicle dermal cells
    Chao Chun Yang
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Dermatol Sci 57:2-11. 2010
    b>Hair follicle stem cells in the epithelial bulge are responsible for the continual regeneration of the hair follicle during cycling. The bulge cells reside in a niche composed of dermal cells...
  27. ncbi The hair follicle-a stem cell zoo
    Viljar Jaks
    Karolinska Institutet, Center for Biosciences and Department of Biosciences and Nutrition, Novum, SE 141 57 Huddinge, Sweden
    Exp Cell Res 316:1422-8. 2010
    Recent studies on stem cells in the adult hair follicle (HF) have uncovered a veritable menagerie of exceptionally diverse and dynamic keratinocytes with stem cell properties located in distinct regions of the HF...
  28. ncbi Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
    Emi K Nishimura
    Department of Pediatric Hematology Oncology, Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 307:720-4. 2005
    ..Furthermore, physiologic aging of melanocyte stem cells was associated with ectopic pigmentation or differentiation within the niche, a process accelerated by mutation of the melanocyte master transcriptional regulator Mitf...
  29. pmc Epidermal stem cells of the skin
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Annu Rev Cell Dev Biol 22:339-73. 2006
    The skin constantly renews itself throughout adult life, and the hair follicle undergoes a perpetual cycle of growth and degeneration...
  30. pmc The tortoise and the hair: slow-cycling cells in the stem cell race
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 137:811-9. 2009
    ..This Review explores the challenges that mammalian stem cells face in balancing the competing demands of proliferation and differentiation in tissues...
  31. pmc The basement membrane of hair follicle stem cells is a muscle cell niche
    Hironobu Fujiwara
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, UK
    Cell 144:577-89. 2011
    The hair follicle bulge in the epidermis associates with the arrector pili muscle (APM) that is responsible for piloerection ("goosebumps")...
  32. pmc BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties
    Michael Rendl
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 22:543-57. 2008
    b>Hair follicle (HF) formation is initiated when epithelial stem cells receive cues from specialized mesenchymal dermal papilla (DP) cells...
  33. ncbi Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34
    Carol S Trempus
    Cancer Biology Group, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Invest Dermatol 120:501-11. 2003
    It is widely believed that epithelial stem cells reside in the hair follicle bulge region. We investigated the hematopoietic stem and progenitor cell marker, CD34, as a potential marker of hair follicle bulge keratinocytes...
  34. ncbi A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis
    R Paus
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    J Invest Dermatol 113:523-32. 1999
    ..mutations develop a hair phenotype, which is often associated with more or less discrete abnormalities in hair follicle development...
  35. ncbi Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge
    Yaping Liu
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 121:963-8. 2003
    Putative epithelial stem cells in the hair follicle bulge are thought to play pivotal roles in the homeostasis, aging, and carcinogenesis of the cutaneous epithelium...
  36. pmc Links between signal transduction, transcription and adhesion in epithelial bud development
    Colin Jamora
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nature 422:317-22. 2003
    ....
  37. ncbi Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
    Mayumi Ito
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 447:316-20. 2007
    The mammalian hair follicle is a complex 'mini-organ' thought to form only during development; loss of an adult follicle is considered permanent...
  38. pmc Epidermal stem cell diversity and quiescence
    Fiona M Watt
    Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, Cambridge, UK
    EMBO Mol Med 1:260-7. 2009
    ..While it is well established that Wnt signalling promotes hair follicle (HF) differentiation, new observations suggest a role for EGF receptor signalling in promoting differentiation ..
  39. pmc Characterization and isolation of stem cell-enriched human hair follicle bulge cells
    Manabu Ohyama
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:249-60. 2006
    The human hair follicle bulge is an important niche for keratinocyte stem cells (KSCs)...
  40. pmc Nestin expression in hair follicle sheath progenitor cells
    Lingna Li
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 100:9958-61. 2003
    ..During early anagen or growth phase of the hair follicle, nestin-expressing cells, marked by GFP fluorescence in nestin-GFP transgenic mice, appear in the permanent ..
  41. ncbi Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis
    S Reddy
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mech Dev 107:69-82. 2001
    Mutations in WNT effector genes perturb hair follicle morphogenesis, suggesting key roles for WNT proteins in this process...
  42. pmc EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair
    Elena Ezhkova
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 25:485-98. 2011
    ..Our findings reveal new insights into Polycomb-dependent tissue control, and provide a new twist to how different progenitors within one tissue respond to loss of H3K27me3...
  43. ncbi Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?
    Michael D Rosenblum
    Department of Pediatrics, Medical College of Wisonsin, Milwaukee, Wisconsin, USA
    J Invest Dermatol 123:880-7. 2004
    ..CD200 expression was accentuated in keratinocytes comprising the outer root sheath of the murine hair follicle (HF)...
  44. pmc Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation
    Demeng Chen
    Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 139:1522-33. 2012
    Dermal fibroblasts are required for structural integrity of the skin and for hair follicle development...
  45. ncbi Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours
    Cristina Lo Celso
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 131:1787-99. 2004
    ..The outgrowths expressed Sonic hedgehog, Patched and markers of hair follicle differentiation, indicative of de novo follicle formation...
  46. pmc Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons
    Yasuyuki Amoh
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 102:5530-4. 2005
    ..the expression of nestin, the neural stem cell marker protein, is expressed in bulge-area stem cells of the hair follicle. We used transgenic mice with GFP expression driven by the nestin regulatory element [nestin-driven GFP (ND-..
  47. ncbi Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis
    Soline Estrach
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 133:4427-38. 2006
    The Wnt and Notch signalling pathways regulate hair follicle maintenance, but how they intersect is unknown...
  48. pmc Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
    Ryan R Driskell
    Wellcome Trust Centre for Stem Cell Research, Cambridge, UK
    Development 136:2815-23. 2009
    The dermal papilla comprises the specialised mesenchymal cells at the base of the hair follicle. Communication between dermal papilla cells and the overlying epithelium is essential for differentiation of the hair follicle lineages...
  49. pmc Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells
    Luis A Garza
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:613-22. 2011
    Androgenetic alopecia (AGA), also known as common baldness, is characterized by a marked decrease in hair follicle size, which could be related to the loss of hair follicle stem or progenitor cells...
  50. ncbi Interferon-gamma is a potent inducer of catagen-like changes in cultured human anagen hair follicles
    T Ito
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Br J Dermatol 152:623-31. 2005
    ..Interferon (IFN)-gamma appears to be an important hair cycle modulator in mice. It is unclear whether it has similar hair growth modulatory functions in human hair follicles...
  51. pmc Molecular dissection of mesenchymal-epithelial interactions in the hair follicle
    Michael Rendl
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America
    PLoS Biol 3:e331. 2005
    De novo hair follicle formation in embryonic skin and new hair growth in adult skin are initiated when specialized mesenchymal dermal papilla (DP) cells send cues to multipotent epithelial stem cells...
  52. ncbi MGF (KIT ligand) is a chemokinetic factor for melanoblast migration into hair follicles
    S A Jordan
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom
    Dev Biol 225:424-36. 2000
    ..Soon after initiation of hair follicle development, melanoblasts localise in the follicles...
  53. ncbi Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice
    Ulrike Lichti
    NIH NCI CCR, Laboratory of Cancer Biology and Genetics, In vitro Pathogenesis Section, 37 Convent Drive, Building 37 4068, Bethesda, Maryland 20892 4255, USA
    Nat Protoc 3:799-810. 2008
    ..Related procedures are also provided: preparing immature hair follicle buds, developing dermal hair follicles and fibroblasts from newborn mice, preparing primary keratinocytes from ..
  54. ncbi Epithelial stem cells: a folliculocentric view
    George Cotsarelis
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 126:1459-68. 2006
    Putative epithelial stem cells were identified in the hair follicle bulge as quiescent "label retaining cells"...
  55. pmc Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
    Haiying Zhang
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:2270-5. 2011
    ..Finally, we identify Cyr61 as a target of YAP in MKs and demonstrate a requirement for TEA domain (TEAD) transcriptional factors to comediate YAP functions in MKs...
  56. ncbi The hair follicle as a dynamic miniorgan
    Marlon R Schneider
    Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany
    Curr Biol 19:R132-42. 2009
    ..The hair shaft consists of terminally differentiated keratinocytes that are produced by the hair follicle. Hair follicle development takes place during fetal skin development and relies on tightly regulated ..
  57. ncbi WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism
    Stefanie Sick
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Science 314:1447-50. 2006
    ..Here we identify WNT and its inhibitor DKK as primary determinants of murine hair follicle spacing, using a combined experimental and computational modeling approach...
  58. ncbi Tcf3 governs stem cell features and represses cell fate determination in skin
    Hoang Nguyen
    Howard Hughes Medical Institute, Department of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, NY 10021, USA
    Cell 127:171-83. 2006
    ..Further, Tcf3-repressed genes include transcriptional regulators of the epidermal, sebaceous gland and hair follicle differentiation programs, and correspondingly, all three terminal differentiation pathways are suppressed when ..
  59. pmc Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination
    S Raghavan
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biol 150:1149-60. 2000
    ..accompanied by massive failure of BM assembly/organization, hemidesmosome instability, and a failure of hair follicle keratinocytes to remodel BM and invaginate into the dermis...
  60. ncbi Sonic hedgehog signaling is essential for hair development
    B St-Jacques
    Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1058-68. 1998
    ..Wnt10b, Sonic hedgehog (Shh) and Bmp2/Bmp4, respectively) in the epidermis correlates with the initiation of hair follicle formation...
  61. ncbi Smad7-induced beta-catenin degradation alters epidermal appendage development
    Gangwen Han
    Department of Otolaryngology, Oregon Health and Science University, Portland, 97239, USA
    Dev Cell 11:301-12. 2006
    ..Smad7 transgene induction perturbed hair follicle morphogenesis and differentiation, but accelerated sebaceous gland morphogenesis...
  62. pmc Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes
    C Brakebusch
    Department of Experimental Pathology, Lund University, S 221 85 Lund, Sweden
    EMBO J 19:3990-4003. 2000
    ..Mutant mice developed severe hair loss due to a reduced proliferation of hair matrix cells and severe hair follicle abnormalities. Eventually, the malformed hair follicles were removed by infiltrating macrophages...
  63. ncbi Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
    Panagiota A Sotiropoulou
    Interdisciplinary Research Institute IRIBHM, Universite Libre de Bruxelles ULB, 808, Route de Lennik, BatC, C6 130, 1070 Brussels, Belgium
    Nat Cell Biol 12:572-82. 2010
    ..Because NHEJ is an error-prone mechanism, this novel characteristic of adult SCs may have important implications in cancer development and ageing...
  64. ncbi The hair cycle
    Laura Alonso
    Department of Medicine, Division of Endocrinology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Cell Sci 119:391-3. 2006
  65. pmc Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice
    David Van Mater
    Departments of Human Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1219-24. 2003
    Wnts have key roles in many developmental processes, including hair follicle growth and differentiation. Stabilization of beta-catenin is essential in the canonical Wnt signaling pathway...
  66. ncbi Identification of the cell lineage at the origin of basal cell carcinoma
    Khalil Kass Youssef
    Universite Libre de Bruxelles ULB, IRIBHM, Brussels B 1070, Belgium
    Nat Cell Biol 12:299-305. 2010
    ..Activation of SmoM2 in hair follicle bulge stem cells and their transient amplifying progenies did not induce cancer formation, demonstrating that ..
  67. pmc Wnt signaling, lgr5, and stem cells in the intestine and skin
    Andrea Haegebarth
    Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The
    Am J Pathol 174:715-21. 2009
    ..target gene Lgr5 has been recently identified as a novel stem cell marker of the intestinal epithelium and the hair follicle. In the intestine, Lgr5 is exclusively expressed in cycling crypt base columnar cells...
  68. ncbi Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
    Hugo J Snippert
    Hubrecht Institute KNAW Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands
    Science 327:1385-9. 2010
    Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene...
  69. ncbi Towards a molecular understanding of hair loss and its treatment
    G Cotsarelis
    Department of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, M8 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104, USA
    Trends Mol Med 7:293-301. 2001
    Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes...
  70. pmc Dynamics between stem cells, niche, and progeny in the hair follicle
    Ya Chieh Hsu
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Cell 144:92-105. 2011
    Here, we exploit the hair follicle to define the point at which stem cells (SCs) become irreversibly committed along a differentiation lineage...
  71. pmc Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction
    Yuhang Zhang
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Cell 17:49-61. 2009
    ..Using hair follicle induction as a model system, we show that patterning of dermal Wnt/beta-catenin signaling requires epithelial ..
  72. ncbi Hair-cycle-associated remodeling of the peptidergic innervation of murine skin, and hair growth modulation by neuropeptides
    E M Peters
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Martinstr. 52, D-20246 Hamburg, Germany
    J Invest Dermatol 116:236-45. 2001
    ..P can manipulate murine hair growth in vivo, we here further studied the role of sensory neuropeptides in hair follicle biology by determining the distribution and hair-cycle-dependent remodeling of the sensory innervation in ..
  73. pmc Paracrine TGF-β signaling counterbalances BMP-mediated repression in hair follicle stem cell activation
    Naoki Oshimori
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 10:63-75. 2012
    b>Hair follicle (HF) regeneration begins when communication between quiescent epithelial stem cells (SCs) and underlying mesenchymal dermal papillae (DP) generates sufficient activating cues to overcome repressive BMP signals from ..
  74. ncbi Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla
    Kevin J McElwee
    Department of Dermatology, Philipp University, Marburg, Germany
    J Invest Dermatol 121:1267-75. 2003
    ..The results indicate transplanted DP and DSC cells were equally capable of DP formation and hair follicle induction. This suggests the DP and peribulbar DSC may be functionally similar...
  75. ncbi Plasticity and cytokinetic dynamics of the hair follicle mesenchyme: implications for hair growth control
    Desmond J Tobin
    Department of Biomedical Sciences, University of Bradford, Bradford, UK
    J Invest Dermatol 120:895-904. 2003
    The continuously remodeled hair follicle is a uniquely exploitable epithelial-mesenchymal interaction system...
  76. ncbi Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation
    Christopher S Potter
    Departments of Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:29245-55. 2006
    It is increasingly evident that the molecular mechanisms underlying hair follicle differentiation and cycling recapitulate principles of embryonic patterning and organ regeneration...
  77. ncbi The bulge area is the major hair follicle source of nestin-expressing pluripotent stem cells which can repair the spinal cord compared to the dermal papilla
    Fang Liu
    AntiCancer Inc, San Diego, CA, USA
    Cell Cycle 10:830-9. 2011
    Nestin has been shown to be expressed in the hair follicle, both in the bulge area (BA) as well as the dermal papilla (DP)...
  78. pmc Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration
    Maksim V Plikus
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Nature 451:340-4. 2008
    ....
  79. ncbi Genetic basis of skin appendage development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, P O Box 56 Viikinkaari 9, University of Helsinki, 00014 Helsinki, Finland
    Semin Cell Dev Biol 18:225-36. 2007
    ..After the bud stage, these organs adopt diverse patterns of epithelial growth, reflected in the usage of more divergent genes in each...
  80. ncbi Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells
    Su yi Tsai
    Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Stem Cells 29:964-71. 2011
    ..We conclude that DP cells may represent a preferred cell type for reprogramming accessible cells with less manipulation and for ultimately establishing safe conditions in the future by replacing Oct4 with small molecules...
  81. ncbi Isolation of murine hair-inducing cells using the cell surface marker prominin-1/CD133
    Yuriko Ito
    Department of Tissue Regeneration, Research Institute, International Medical Center of Japan, Toyama, Shinjuku, Tokyo, Japan
    J Invest Dermatol 127:1052-60. 2007
    Hair is a mini-organ in which dermal papilla (DP) cells play important roles in hair follicle morphogenesis and formation via interactions with epithelial cells...
  82. pmc Wnt signaling maintains the hair-inducing activity of the dermal papilla
    J Kishimoto
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 14:1181-5. 2000
    The formation of the hair follicle and its cyclical growth, quiescence, and regeneration depend on reciprocal signaling between its epidermal and dermal components...
  83. pmc Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves
    Yasuyuki Amoh
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 102:17734-8. 2005
    The hair follicle bulge area is an abundant, easily accessible source of actively growing, pluripotent adult stem cells...
  84. pmc Noninvasive method for assessing the human circadian clock using hair follicle cells
    Makoto Akashi
    Research Institute for Time Studies, Yamaguchi University, Yamaguchi 753 8511, Japan
    Proc Natl Acad Sci U S A 107:15643-8. 2010
    ..reliable, and less invasive method for detecting human clock gene expression using biopsy samples of hair follicle cells from the head or chin...
  85. ncbi Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition
    Petra C Arck
    Biomedizinisches Forschungszentrum, Campus Virchow Klinikum, Charite University Medicine, Augustenburger Platz 1, 13353 Berlin, Germany
    J Mol Med (Berl) 83:386-96. 2005
    ..Recently we revealed the existence of a "brain-hair follicle axis" by characterizing the neurokinin (NK) substance P (SP) as a central element in the stress-induced threat ..
  86. pmc TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis
    Monika Petersson
    Center for Molecular Medicine Cologne CMMC, Institute of Pathology, University of Cologne, Cologne, Germany
    EMBO J 30:3004-18. 2011
    ..This process of de novo SG formation is accompanied by the establishment of new progenitor niches. Detailed molecular analysis suggests the recapitulation of steps of tissue morphogenesis...
  87. ncbi Hair cycle-dependent changes of alkaline phosphatase activity in the mesenchyme and epithelium in mouse vibrissal follicles
    Machiko Iida
    Division of Resources Life Science, The United Graduate School of Agricultural Sciences, Tottori University, 4 101 Koyama Minami, Tottori 680 8553, Japan
    Dev Growth Differ 49:185-95. 2007
    ..These dynamic changes of ALP expression might be related to DP's functions in hair induction and also to reconstruction of the bulbar structure during the hair cycle...
  88. ncbi The interfollicular epidermal stem cell saga: sensationalism versus reality check
    Pritinder Kaur
    Epithelial Stem Cell Biology Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, VIC 3002, Australia
    Exp Dermatol 20:697-702. 2011
    ..Although this view remains firmly embedded in the skin field, particularly in the area of hair follicle stem cell biology, it has been challenged by a number of notable publications in 2007...
  89. pmc Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
    Karen M Osorio
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 193:235-50. 2011
    Runx1 controls hematopoietic stem cell emergence and hair follicle stem cell (HFSC) activation and proliferation in adult skin...
  90. ncbi Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro
    E A Langan
    Dermatological Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, UK
    Br J Dermatol 162:1127-31. 2010
    ..However, how the expression of PRL and PRL receptor (PRLR) is regulated in human skin is unknown...
  91. ncbi Promotion of hair follicle development and trichogenesis by Wnt-10b in cultured embryonic skin and in reconstituted skin
    Yukiteru Ouji
    Program in Tissue Engineering and Department of Parasitology, Nara Medical University, Kashihara, Nara, Japan
    Biochem Biophys Res Commun 345:581-7. 2006
    ..the differentiation of primary skin epithelial cells (MPSEC) toward hair shaft and inner root sheath of the hair follicle (IRS) cells in vitro...
  92. pmc Delayed cutaneous wound healing and aberrant expression of hair follicle stem cell markers in mice selectively lacking Ctip2 in epidermis
    Xiaobo Liang
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, United States of America
    PLoS ONE 7:e29999. 2012
    ....
  93. pmc Endogenous retinoids in the hair follicle and sebaceous gland
    Helen B Everts
    Department of Human Nutrition, The Oio State University, 350 Campell Hall, 1787 Neil Ave, Columbus, OH 43210, USA
    Biochim Biophys Acta 1821:222-9. 2012
    ..This review discusses the localization of RA synthesis to specific sites within the hair follicle and sebaceous gland, including their stem cells, during both homeostasis and disease states...
  94. ncbi Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis
    Karin List
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA
    Oncogene 21:3765-79. 2002
    ..Loss of Matriptase/MT-SP1 also seriously affected hair follicle development resulting in generalized follicular hypoplasia, absence of erupted vibrissae, lack of vibrissal ..
  95. pmc More than one way to skin . .
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 22:976-85. 2008
    ..interactions to differentially adopt the cell fates that enable them to form the epidermis, hair follicle, and sebaceous gland...
  96. pmc Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells
    Ying V Zhang
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Cell Stem Cell 5:267-78. 2009
    ..Here, we examine the dynamic behavior of adult hair follicle stem cells in their normal setting by employing mice with repressible H2B-GFP expression to track cell ..
  97. ncbi Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis
    Anna Brancaccio
    Telethon Institute of Genetics and Medicine TIGEM, Via Pietro Castellino 111, 80131 Napoli, Italy
    Hum Mol Genet 13:2595-606. 2004
    The forkhead transcription factor FOXE1 is mutated in patients with Bamforth-Lazarus syndrome that exhibit hair follicle defects, suggesting a possible role for Foxe1 in hair follicle morphogenesis...
  98. pmc The pathogenesis of primary cicatricial alopecias
    Matthew J Harries
    Dermatology Centre, University of Manchester, Manchester, UK
    Am J Pathol 177:2152-62. 2010
    ..alopecia results from irreversible damage to epithelial stem cells located in the bulge region of the hair follicle, generally as a result of inflammatory mechanisms (eg, in the context of autoimmune disease)...
  99. ncbi Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling
    W Roth
    Institut für Molekulare Medizin und Zellforschung, Albert Ludwigs Universitat Freiburg, 79106 Freiburg, Germany
    FASEB J 14:2075-86. 2000
    ..The hair loss is due to alterations of hair follicle morphogenesis and cycling, dilatation of hair follicle canals, and disturbed club hair formation...
  100. ncbi An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution
    Abigail K Langton
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Invest Dermatol 128:1311-8. 2008
    ..However, the functional requirements for this hair follicle input are unknown...
  101. pmc Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy
    Eniko Bodo
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, D 23538 Lubeck, Ratzeburger Allee 160, Germany
    Am J Pathol 171:1153-67. 2007
    ..Thus, this novel system serves as a powerful yet pragmatic tool for dissecting and manipulating the impact of chemotherapy on the human HF...

Research Grants72

  1. Targeting p53-Dependent Repigmentation in Vitiligo
    TAMARA G TERZIAN; Fiscal Year: 2013
    ..for vitiligo is a classic example of regenerative medicine where activation of a stem cell population in a hair follicle niche can produce differentiated melanocytes that will repopulate the interfollicular epidermis and restore ..
  2. Cicatricial Alopecia Research Symposium 2011: Lipids, Inflammation &Stem Cells
    Pratima Karnik; Fiscal Year: 2011
    ..a strong emphasis on three major thematic areas 1) inflammation and inflammatory cells that target the hair follicle, 2) the role of nuclear receptors and lipids in skin and hair biology, and 3) importance and fate of hair ..
  3. Skin Regeneration with Stem Cells and Scaffolds
    SUSAN RENEE OPALENIK; Fiscal Year: 2013
    ..of connective tissue architecture, including the formation of functional elastic fibers and the initiation of hair follicle formation...
  4. TNF Alpha in PKC Epsilon Signaling to Carcinogenesis
    Ajit K Verma; Fiscal Year: 2013
    ..alpha (TNF1) and granulocyte colony-stimulating factor (G-CSF) which may directly promote the proliferation of hair follicle stem cells, the targets of SCC...
  5. MAMMALIAN POLYAMINE METABOLISM
    David J Feith; Fiscal Year: 2013
    ..First, skin sections will be analyzed to identify the developmental defects in hair follicle morphogenesis and cycling that are induced by AZ and AdoMetDC expression...
  6. Identification and Characterization of Adult Salivary Gland Stem Cells
    Soosan Ghazizadeh; Fiscal Year: 2013
    ..We also showed that these cells functioned independently of hair follicle stem cells located in the bulge...
  7. Stat3 in Epitherlial Carcinogenesis
    John DiGiovanni; Fiscal Year: 2012
    ..revealed that Stat3 is required for survival of DNA damaged keratinocytes, including those located in the hair follicle bulge region (i.e., stem cell compartment)...
  8. DEVELOPMENT AND REGENERATION OF SKIN APPENDAGES
    Cheng Ming Chuong; Fiscal Year: 2013
    ..2) The cycling of a single hair follicle has been studied, but the regenerative behavior of a population of hair follicles has not been studied...
  9. Cellular Determinants of Ah Receptor Signaling
    Thomas R Sutter; Fiscal Year: 2013
    ..of the interfollicular squamous epithelium, hyperproliferation and hyperkeratinization of cells of the hair follicle, as well as a metaplastic response of the ductular sebaceous glands...
  10. Epidermal stem cell properties in mice with altered polyamines
    Lisa M Shantz; Fiscal Year: 2010
    ..induces genetic changes in epidermal stem cells, which are thought to be located in the bulge region of the hair follicle. Initiation causes activation of the Ha-ras oncogene and chronic up-regulation of the Raf/MEK/ERK pathway...
  11. Cell Adhesion and Cytoskeletal Dynamics in Skin
    Elaine Fuchs; Fiscal Year: 2013
    ..self-renewing skin epithelium maintains and repairs its surface barrier and how a stem cell can give rise to a hair follicle (HF)...
  12. Skin Stem Cells: Purification and Characterization
    Elaine Fuchs; Fiscal Year: 2013
    ..basal) layer of the interfollicular epidermis (IFE) as well as the bulge, a niche located within the hair follicle (HF)...
  13. Role of vitamin D and calcium signaling in wound healing
    DANIEL DAVID BIKLE; Fiscal Year: 2013
    ..Stem cells in the bulge of the hair follicle provide keratinocytes not only for hair follicle formation but also for the reepithelialization of the ..
  14. PPAR-gamma Signaling in Normal Pilosebaceous Units and in Scarring Alopecia
    Pratima Karnik; Fiscal Year: 2013
    ..lost in lichen planopilaris (LPP), a lymphocytic CA, and that targeted deletion of PPAR in stem cells of the hair follicle causes scarring alopecia...
  15. Ligand independent signaling by VDR in Keratinocytes
    Paul N MacDonald; Fiscal Year: 2010
    ..These data as well as published data on hair follicle cycling in these mouse models and in humans, point to a novel ligand-independent role for VDR in keratinocytes...
  16. Characterization of neural crest stem cells in human hair follicles.
    Xiaowei Xu; Fiscal Year: 2013
    ..We hypothesize that human hair follicle NCSCs retain pluripotency and have similar functions as embryonic NCSCs...
  17. Role of Beta 1 containing Integrins in Cutaneous Basement Membrane Organization
    Srikala Raghavan; Fiscal Year: 2010
    ..membrane assembly and organization are central to many biological and pathological processes, including hair follicle morphogenesis, wound healing and cancer metastasis...
  18. Keratins, Wound Reepithelialization, and Hair Follicle Cycling
    PIERRE COULOMBE; Fiscal Year: 2013
    ..In Aim 1, we will build new mouse models that will further our understanding of the role of keratins during hair follicle cycling, wound repair, and disease...
  19. Functional Analysis of the Hairless Protein
    Angela M Christiano; Fiscal Year: 2012
    ..applicant): Our work during the first award period was focused on defining the functions of HR in the skin and hair follicle. We have been working to understand what controls hairless expression and have shown that hr is regulated by ..
  20. The Role of Calcium Signaling in Stem Cell Quiescence
    Gozde Yucel; Fiscal Year: 2010
    ..The murine hair follicle undergoes repeated, genetically controlled cycles of proliferation (anagen), regression (catagen) and ..
  21. Genome Wide Association Studies in Alopecia Areata
    Angela M Christiano; Fiscal Year: 2012
    ..genes containing the SNPs of interest will be prioritized using mRNA and protein expression patterns in the hair follicle. The positional information will be cross-referenced with information derived from expression studies in mouse ..
  22. Extrinsic Regulation of Epidermal Homeostatasis
    Valerie Horsley; Fiscal Year: 2013
    ..stem cells are responsible for the maintenance and regeneration of self-renewing tissues such as epidermis, hair follicle, and mammary gland...
  23. Topical DNA immunization by modifying the hair follicle cycle
    Zhengrong Cui; Fiscal Year: 2011
    ..and validation of this novel topical DNA immunization approach in future (clinical) trials by modifying the hair follicle cycle...
  24. Regulation of Quiescence and Activation in Skin Stem Cells
    Ya Chieh Hsu; Fiscal Year: 2013
    ..The hair follicle, one of the important skin appendages, is an ideal paradigm to address this problem...
  25. Planar Cell Polarity Signaling in Hair Follicle Formation
    Jiang Chen; Fiscal Year: 2013
    ..Recent studies have also implicated PCP signaling in the development of a skin appendage, the hair follicle. Specifically, core PCP genes of this signaling pathway have been shown to control the orientation of the hair ..
  26. Animal Model to Study Retinoic Acid Function in Postnatal and Adult Tissues
    GREGG L DUESTER; Fiscal Year: 2012
    ..functions including hippocampal neurogenesis, immune function, spermatogenesis, stem cell function, skin and hair follicle regeneration, and prevention of cancer...
  27. Characterizing interactions of the VDR and the canonical Wnt signatling pathway
    Hilary F Luderer; Fiscal Year: 2010
    ..Previous studies demonstrated that this is due to loss of ligand-independent functions of the VDR in the hair follicle resulting in decreased keratinocyte stem cell (KSC) number...
  28. Function of KLF4-expressing stem cells in mouse cutaneous wound healing
    Walden Ai; Fiscal Year: 2013
    ..Our preliminary data also showed that KLF4-expressing pluripotent cells, probably hair follicle stem cells, migrate from its original position toward the wound during wound healing, indicating that these ..
  29. Molecular Mechanisms of Cell Fate Decisions in Hair Follicle Stem Cells
    Tudorita Tumbar; Fiscal Year: 2013
    ..Because hair follicle stem cells synchronously proliferate and return to quiescence in the mouse skin, this system allows ..
  30. REGULATION OF EPIDERMAL DEVELOPMENT AND DIFFERENTIATION
    Elaine Fuchs; Fiscal Year: 2013
    ..goal is to understand how adult skin maintains and transcriptionally regulates a pool of stem cells in the hair follicle (HF-SCs) that drive new growth during the hair cycle and repair the epidermis upon injury...
  31. Molecular control of normal and neoplastic skin stem cells
    Andrey Sharov; Fiscal Year: 2013
    ..l)Compare molecular signature and BMP target genes in stem cells isolated from normal mouse skin and from hair follicle-derived tumors of K14-Noggin transgenic mice...
  32. Peripheral Mechanisms Governing Tactile Encoding During Normal Target Remodeling
    Ellen A Lumpkin; Fiscal Year: 2013
    ..By identifying mechanisms that govern the reliability of touch-evoked signals in healthy skin, these studies will set the stage to determine how these mechanisms fail in aging and pathophysiological states. ..
  33. The role of prostaglandin d2 in hair follicle biology
    LUIS ANDRES GARZA; Fiscal Year: 2012
    ..Finally, based on current literature, we hypothesize that the mechanism of PGD2 mediated hair follicle miniaturization and sebaceous hyperplasia is through bias of hair follicle stem cell fate from hair ..
  34. Role of Desmosomal Adhesion in Carcinogenesis
    MY GEORGIA MAHONEY; Fiscal Year: 2013
    ..infectious and heritable diseases highlighting their roles in cell-cell adhesion, skin barrier function, and hair follicle development...
  35. 14-3-3?? and epithelial differentiation in the eye and other tissues
    Qiutang Li; Fiscal Year: 2012
    ..of proliferating progenitor cells and a phenotype indistinguishable from that of Notch 1 in the cornea, hair follicle and ductal structures such as those in the meibomian gland...
  36. mTOR-dependent pathways in skin carcinogenesis
    Lisa M Shantz; Fiscal Year: 2011
    ..A number of studies have indicated that stem cells within the hair follicle bulge give rise to NMSC...
  37. Juvenile mouse model of delayed anthracycline cardiotoxicity
    Asa B Gustafsson; Fiscal Year: 2013
    ..is also the basis for hair loss during chemotherapy, as the vascular structures supporting the hair follicle involute...
  38. Role of Cilia/IFT in Skin and Hair
    Bradley K Yoder; Fiscal Year: 2012
    ..The role of primary cilia in skin and hair follicle biology remains completely unexplored...
  39. The Vitamin D Receptor:ligand-dependent and independent actions
    Marie Demay; Fiscal Year: 2013
    ..We have demonstrated that the ligand-independent actions of the VDR are required for hair follicle keratinocyte stem cell (KSC) function, normal hair cycling and canonical Wnt (cWnt) signaling in keratinocytes...
  40. Epithelial Stem Cell Migration during Wound Repair
    CATHERINE PEI JU LU; Fiscal Year: 2013
    ..requires skin epithelial stem cells, which migrate in both from the surrounding epidermis and also from the hair follicle. However, very little is known about the signals that activate stem cell migration and the molecular ..
  41. MOLECULAR REGULATION OF HAIR FOLLICLE MORPHOGENESIS
    Andrzej A Dlugosz; Fiscal Year: 2013
    ..by applicant): The long-term goal of this grant is to further our understanding of the molecular regulation of hair follicle development and cycling, with the hope that this new knowledge will provide clues to the pathogenesis of hair ..
  42. Specification of Dermal Papilla Cell Fate in the Hair Follicle Stem Cell Niche
    Michael Rendl; Fiscal Year: 2013
    ..We have recently developed novel genetic tools to study dermal papilla (DP) cells in the hair follicle SC niche, which are thought to direct follicular SC fate...
  43. Laminins in the Skin
    MATT PETER MARINKOVICH; Fiscal Year: 2013
    ..which acts upon the dermal papilla (DP), allowing it to properly respond to the follicular epithelium during hair follicle elongation...
  44. The role of p63 in hair follicle stem cells and cancer
    Maranke I Koster; Fiscal Year: 2013
    ..These studies will have implications for the treatment of hair abnormalities in patients with p63-related ectodermal dysplasias as well as for the treatment of patients with skin cancer. ..
  45. Inductive properties of the dermal papilla of the hair follicle
    Bruce A Morgan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The hair follicle has emerged as an important focus of research not only because of the psychological and emotional impacts of hair loss or excessive hair growth, but also because the hair follicle ..
  46. Cell-cell adhesion and signal transduction
    Valeri Vasioukhin; Fiscal Year: 2012
    ..We have evidence that deletion of 1E-catenin in skin hair follicle stem cell compartment results in development of completely penetrant skin tumors...
  47. Regulation of Dermal Fibroblasts in Skin Regeneration and Healing
    Thomas N Darling; Fiscal Year: 2013
    ..TSC2 is a protein that inhibits mTORC1 and other growth signaling pathways, and it appears to regulate hair follicle morphogenesis and skin regeneration...
  48. GENETIC MECHANISMS IN SKIN DISEASES
    DAVID RINSEY BICKERS; Fiscal Year: 2010
    ..mechanisms of carcinogenesis, the molecular basis of inherited skin and hair disorders, stem cells, control of hair follicle cycling, chemoprevention of skin cancer, cell cycle control, and pigmentation...
  49. Coordinated Regulation of Hair Growth and Pigmentation by Dermal Papilla Cells
    Yuhang Zhang; Fiscal Year: 2013
    ..The hair follicle is a self-renewing mini-organ supported by the proliferation and differentiation of follicular SCs of ..
  50. Identification of a Keratinocyte Stem Cell Regulatory Gene in the KSC2 Locus
    REBECCA JANE MORRIS; Fiscal Year: 2013
    ..This project not only has basic science ramifications for understanding hair follicle and epidermal homeostasis, it may have clinical impact for the diagnosis, prevention, and treatment of skin ..
  51. The regulation of melanocyte stem cells by Wnt signaling
    Mayumi Ito; Fiscal Year: 2013
    ..goal of this grant is to understand the function of Wnt signaling and its regulation in McSCs residing in the hair follicle. McSCs are coordinately activated with follicular epithelial stem cells (EpSCs) during the cyclical ..
  52. Vitamin D Receptor Coactivators in Keratinocytes
    DANIEL DAVID BIKLE; Fiscal Year: 2013
    ..while promoting keratinocyte differentiation leading to a protective epidermal barrier and normal hair follicle cycling...
  53. Elucidating the functions of epigenetic regulators in control of skin stem cells
    Elena Ezhkova; Fiscal Year: 2013
    ..In an adult organism, separate pools of epidermal and hair follicle stem cells control skin maintenance throughout the lifespan of the animal...
  54. Investigating the role of Hopx in cardiac progenitor proliferation
    Rajan Jain; Fiscal Year: 2013
    ..Recent studies have also identified specific Hopx expression in adult intestine and hair follicle stem cells...
  55. Function and mechanism of LGR4 and LGR5 in modulation of Wnt signaling
    Qingyun Liu; Fiscal Year: 2013
    ..is specifically expressed in the rapidly cycling crypt stem cells of the entire gastrointestinal tract and hair follicle stem cells in the bulge whie LGR4 is essential for survival of the crypt stem cells...
  56. Bone Morphogentic Protein signaling in the control of skin development, hair grow
    Vladimir Botchkarev; Fiscal Year: 2009
    ..Define the role of the BMP-Smad signaling in the reprogramming of normal hair follicle stem cells and/or their progenies towards the tumor progenitor cell phenotype. 2...
  57. Dissecting stage-specific roles of TGF-beta in epidermal tumor progression
    Naoki Oshimori; Fiscal Year: 2013
    ..I have shown that TGF[unreadable] plays a pivotal role in hair follicle regeneration by inducing quiescent stem cells to proliferate and migrate by counteracting repressive BMP ..
  58. Bone Morphogentic Protein signaling in the control of skin development, hair grow
    Vladimir A Botchkarev; Fiscal Year: 2013
    ..Define the role of the BMP-Smad signaling in the reprogramming of normal hair follicle stem cells and/or their progenies towards the tumor progenitor cell phenotype. 2...
  59. WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTH
    Sarah E Millar; Fiscal Year: 2013
    ..These pathways can interact with each other, and perform critical functions in skin and hair follicle development and disease...
  60. Exploring How Dermal Papilla Precursors Regulate Hair Follicle Formation
    Michael Rendl; Fiscal Year: 2013
    ..b>Hair follicle (HF) morphogenesis is an excellent model system for SC regulation by niche signals, since the developmental ..
  61. Interfollicular epidermal stem cells in human and mouse skin
    DENISE LEA GAY; Fiscal Year: 2011
    ..Although hair follicle stem cells in the bulge have been well characterized, our understanding of stem cells in the interfollicular ..
  62. MOLECULAR BASIS OF EPITHELIAL SKIN CANCER
    Andrzej A Dlugosz; Fiscal Year: 2013
    ..Although basal cell carcinoma tumor progenitors reside within the epithelial stem cell niche of the hair follicle, called the bulge, mobilization to form a transit amplifying cell population (a Wnt-mediated process) is ..
  63. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..This will be evaluated in human hair follicle grown ex vivo and in isolated sub-populations of hair follicle-derived follicular melanocytes and ..
  64. FUNCTION OF NOGGIN IN HAIR FOLLICLE GROWTH AND DISEASE
    Vladimir Botchkarev; Fiscal Year: 2006
    ..common hair growth disorders (androgenic alopecia and alopecia areata) are characterized by the development of hair follicle miniaturization with significant elongation of the resting stage, shortening of the growth stage of hair cycle,..
  65. A ROLE FOR NOGGIN AND BMP2/4 IN HAIR GROWTH CONTROL
    Vladimir Botchkarev; Fiscal Year: 2003
    ..two of the most common hair growth disorder (androgenic alopecia and alopecia areata) are characterized by hair follicle miniaturization with significant elongation of the resting stage, shortening of the growth stage of the hair ..
  66. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2005
    ..Our recent results suggest that the hair follicle is a promising source for such stem cells...
  67. Placental growth factor in skin angiogenesis
    Michael Detmar; Fiscal Year: 2001
    ..development, normal adult skin exhibits little vascular proliferation, with the exception of the cycling hair follicle. However, angiogenesis is a characteristic feature of inflammatory and neoplastic diseases and has been ..
  68. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..Our recent results suggest that the hair follicle is a promising source for such stem cells...
  69. HAIR FOLLICLE BULGE CELLS IN TUMORIGENESIS AND ALOPECIA
    George Cotsarelis; Fiscal Year: 2009
    ..Epithelial stem cells are responsible for the regeneration of self-renewing tissues such as epidermis, hair follicle, and cornea. We originally identified putative epithelial stem cells in the bulge of the hair follicle...
  70. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..For example, toward this goal, we have previously developed a selective topical liposome hair follicle targeting technology fo r genes and other large and small molecules...
  71. Molecular & cellular biology of hair follicle stem cells
    Stephen Lyle; Fiscal Year: 2006
    The overall goal of this project is to characterize the expression of genes within hair follicle stem cells and to study the role of specific genes in maintaining the stem cell phenotype...
  72. Endothelial Progenitor Cells in Multiple Myeloma
    Olcay Batuman; Fiscal Year: 2006
    ..EPCs display an extremely skewed (> 90%) pattern of X-chromosome inactivation, whereas lymphocyte and hair follicle specimens from the same patients revealed a random inactivation pattern...