hair

Summary

Summary: A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.

Top Publications

  1. doi Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
    Hugo J Snippert
    Hubrecht Institute KNAW Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands
    Science 327:1385-9. 2010
  2. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
  3. pmc beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair
    David Enshell-Seijffers
    Cutaneous Biology Research Center, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
    Dev Cell 18:633-42. 2010
  4. ncbi Controls of hair follicle cycling
    K S Stenn
    Beauty Genome Sciences Inc, Skillman, New Jersey, USA
    Physiol Rev 81:449-494. 2001
  5. ncbi Epidermal stem cells arise from the hair follicle after wounding
    Vered Levy
    Cutaneous Biology Research Center, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    FASEB J 21:1358-66. 2007
  6. pmc Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop
    Wei Meng Woo
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 26:1235-46. 2012
  7. ncbi A subset of skin-expressed microRNAs with possible roles in goat and sheep hair growth based on expression profiling of mammalian microRNAs
    Zhang Wenguang
    Key Laboratory of Animal Genetics, Breeding and Reproduction, Nei Mongol Autonomous Region, Hohhot, PR China
    OMICS 11:385-96. 2007
  8. pmc Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration
    Piul Rabbani
    Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    Cell 145:941-55. 2011
  9. pmc Complex hair cycle domain patterns and regenerative hair waves in living rodents
    Maksim V Plikus
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Invest Dermatol 128:1071-80. 2008
  10. pmc Common variants in the trichohyalin gene are associated with straight hair in Europeans
    Sarah E Medland
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 85:750-5. 2009

Detail Information

Publications338 found, 100 shown here

  1. doi Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
    Hugo J Snippert
    Hubrecht Institute KNAW Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands
    Science 327:1385-9. 2010
    Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene...
  2. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    b>Hair follicle morphogenesis is initiated by a dermal signal that induces the development of placodes in the overlying epithelium...
  3. pmc beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair
    David Enshell-Seijffers
    Cutaneous Biology Research Center, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
    Dev Cell 18:633-42. 2010
    The activity of keratinocytes in the hair follicle is regulated by signals from a specialized mesenchymal niche, the dermal papilla (DP)...
  4. ncbi Controls of hair follicle cycling
    K S Stenn
    Beauty Genome Sciences Inc, Skillman, New Jersey, USA
    Physiol Rev 81:449-494. 2001
    Nearly 50 years ago, Chase published a review of hair cycling in which he detailed hair growth in the mouse and integrated hair biology with the biology of his day...
  5. ncbi Epidermal stem cells arise from the hair follicle after wounding
    Vered Levy
    Cutaneous Biology Research Center, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    FASEB J 21:1358-66. 2007
    During normal development, the epidermis and hair follicle are distinct lineage compartments maintained by independent stem cell populations...
  6. pmc Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop
    Wei Meng Woo
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 26:1235-46. 2012
    During hair follicle morphogenesis, dermal papillae (DPs) function as mesenchymal signaling centers that cross-talk with overlying epithelium to regulate morphogenesis...
  7. ncbi A subset of skin-expressed microRNAs with possible roles in goat and sheep hair growth based on expression profiling of mammalian microRNAs
    Zhang Wenguang
    Key Laboratory of Animal Genetics, Breeding and Reproduction, Nei Mongol Autonomous Region, Hohhot, PR China
    OMICS 11:385-96. 2007
    ..In order to identify mammalian miRNAs that might function in hair growth, we characterized the expression of 159 miRNAs in adult body side skin and ear skin from goat and sheep ..
  8. pmc Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration
    Piul Rabbani
    Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    Cell 145:941-55. 2011
    Melanocyte stem cells (McSCs) intimately interact with epithelial stem cells (EpSCs) in the hair follicle bulge and secondary hair germ (sHG). Together, they undergo activation and differentiation to regenerate pigmented hair...
  9. pmc Complex hair cycle domain patterns and regenerative hair waves in living rodents
    Maksim V Plikus
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Invest Dermatol 128:1071-80. 2008
    Single hair follicles go through regeneration and involution cycles. In a population, hair follicles may affect each other during anagen re-entry, thus forming propagating regenerative hair waves...
  10. pmc Common variants in the trichohyalin gene are associated with straight hair in Europeans
    Sarah E Medland
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 85:750-5. 2009
    b>Hair morphology is highly differentiated between populations and among people of European ancestry...
  11. ncbi Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia
    M Ridanpaa
    Folkhalsan Institute of Genetics, 00280 Helsinki, Finland
    Cell 104:195-203. 2001
    The recessively inherited developmental disorder, cartilage-hair hypoplasia (CHH) is highly pleiotropic with manifestations including short stature, defective cellular immunity, and predisposition to several cancers...
  12. ncbi The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 129:2495-505. 2002
    ..organ of Corti from within the cochlear epithelium is patterned into a stereotyped array of inner and outer sensory hair cells separated from each other by non-sensory supporting cells...
  13. pmc Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations
    Sophie I Candille
    Department of Genetics, Stanford University, Stanford, California, United States of America
    PLoS ONE 7:e48294. 2012
    Pigmentation of the skin, hair, and eyes varies both within and between human populations...
  14. ncbi Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate
    P Zhou
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA
    Genes Dev 9:700-13. 1995
    ..We noticed that genes involved in hair-specific gene expression possess LEF-1/TCF-1 consensus motifs located in similar positions relative to their TATA ..
  15. doi Risk of Toxocara canis eggs in stray and domestic dog hair in Egypt
    Wael F El-Tras
    Department of Hygiene and Preventive Medicine Zoonoses, Faculty of Veterinary Medicine, Kafrelsheikh University, Elgesh, Kafrelsheikh 33516, Egypt
    Vet Parasitol 178:319-23. 2011
    The aim of the study was to assess whether the hair of stray and domestic dogs in Egypt was contaminated with the eggs of the zoonotic parasite Toxocara canis, and also to identify risk factors for T. canis for contamination...
  16. ncbi Sonic hedgehog signaling is essential for hair development
    B St-Jacques
    Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1058-68. 1998
    ..In each case the specific structure (for example scale, feather or hair) arises from an epidermal placode as a result of epithelial-mesenchymal interactions with the underlying dermal ..
  17. doi Two newly identified genetic determinants of pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 40:835-7. 2008
    ..Two coding variants in TPCN2 are associated with hair color, and a variant at the ASIP locus shows strong association with skin sensitivity to sun, freckling and red ..
  18. ncbi Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Arterioscler Thromb Vasc Biol 25:228-33. 2005
    ..We investigated the effects of high mercury content in hair on the risk of acute coronary events and cardiovascular and all-cause mortality in men from eastern Finland.
  19. pmc The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles
    Thomas Andl
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 16:1041-9. 2006
    ..We found that Dicer mRNA and multiple miRNAs are expressed in mouse skin, suggesting roles in skin- and hair-follicle biology...
  20. pmc Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles
    Danelle Devenport
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Nat Cell Biol 10:1257-68. 2008
    ..discovered that during embryogenesis, marked changes in cell shape and cytoskeletal polarization occur as nascent hair follicles become anteriorly angled, morphologically polarized and molecularly compartmentalized along the A-P axis...
  21. pmc Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice
    David Van Mater
    Departments of Human Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1219-24. 2003
    Wnts have key roles in many developmental processes, including hair follicle growth and differentiation. Stabilization of beta-catenin is essential in the canonical Wnt signaling pathway...
  22. pmc Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair
    Viviana Cordeddu
    Dipartimento di Ematologia, Oncologia e Medicina Molecolare, Istituto Superiore di Sanita, Rome, Italy
    Nat Genet 41:1022-6. 2009
    ..subjects with a relatively consistent phenotype previously termed Noonan-like syndrome with loose anagen hair (MIM607721) shared the 4A>G missense change in SHOC2 (producing an S2G amino acid substitution) that introduces ..
  23. pmc Hair as a biomarker of environmental manganese exposure
    Rachel R Eastman
    Microbiology and Environmental Toxicology Department, University of California, Santa Cruz, California 95064, United States
    Environ Sci Technol 47:1629-37. 2013
    ..We developed a hair cleaning methodology to establish the utility of hair as an exposure biomarker for Mn and other metals (Pb, Cr, Cu),..
  24. pmc Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline
    Woo Chi
    Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA
    Development 140:1676-83. 2013
    Although the hair shaft is derived from the progeny of keratinocyte stem cells in the follicular epithelium, the growth and differentiation of follicular keratinocytes is guided by a specialized mesenchymal population, the dermal papilla (..
  25. ncbi Determination of hair structure and shape
    Thomas Schlake
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Semin Cell Dev Biol 18:267-73. 2007
    The hair follicle attracted significant attention as a model for the investigation of diverse biological problems...
  26. pmc Molecular evidence for a diverse green algal community growing in the hair of sloths and a specific association with Trichophilus welckeri (Chlorophyta, Ulvophyceae)
    Milla Suutari
    Department of Environmental Sciences, P, O, Box 65, FIN 00014, University of Helsinki, Helsinki, Finland
    BMC Evol Biol 10:86. 2010
    ..However, this phenomenon has not been explored in any detail and there is little evidence to substantiate this widely held opinion...
  27. doi Topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating Shh and β-catenin expression in C57BL/6 mice
    Hye Jin Park
    Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang dong, Kwangjin gu, Seoul 143 701, Republic of Korea
    J Ethnopharmacol 135:369-75. 2011
    Polygonum multiflorum has traditionally been used for treating patients suffering from baldness and hair loss in East Asia.
  28. ncbi FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations
    J M Hebert
    Department of Anatomy and Programs in Genetics and in Developmental Biology, School of Medicine, University of California, San Francisco 94143
    Cell 78:1017-25. 1994
    ..null allele of the Fgf5 gene, fgf5neo, produced by gene targeting in embryonic stem cells, have abnormally long hair. This phenotype appears identical to that of mice homozygous for the spontaneous mutation angora (go)...
  29. ncbi Hair-inducing ability of human dermal papilla cells cultured under Wnt/β-catenin signalling activation
    Tsutomu Soma
    Exp Dermatol 21:307-9. 2012
    It is well known that dermal papilla cells (DPCs) play crucial roles in hair follicle induction. In this study, we examined whether Wnt/β-catenin activation results in maintenance of the hair-inducing ability of human DPCs...
  30. pmc Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation
    Jing Cai
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 326:420-30. 2009
    b>Hair shafts are produced from stem cells located in the bulge...
  31. pmc Maternal fish consumption, hair mercury, and infant cognition in a U.S. Cohort
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Environ Health Perspect 113:1376-80. 2005
    ..We examined associations of maternal fish intake during pregnancy and maternal hair mercury at delivery with infant cognition among 135 mother-infant pairs in Project Viva, a prospective U.S...
  32. ncbi Hox in hair growth and development
    Alexander Awgulewitsch
    Departments of Medicine and Dermatology, and Hollings Cancer Center, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 912, Charleston, SC 29425, USA
    Naturwissenschaften 90:193-211. 2003
    ..Among these, the hair follicle is of particular interest, as it is the only organ undergoing cyclical phases of regression and ..
  33. pmc Stable isotopes in elephant hair document migration patterns and diet changes
    Thure E Cerling
    Department of Geology and Geophysics, 135 South 1460 East, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 103:371-3. 2006
    We use chronologies of stable isotopes measured from elephant (Loxodonta africana) hair to determine migration patterns and seasonal diet changes in elephants in and near Samburu National Reserve in northern Kenya...
  34. ncbi Plasticity and cytokinetic dynamics of the hair follicle mesenchyme: implications for hair growth control
    Desmond J Tobin
    Department of Biomedical Sciences, University of Bradford, Bradford, UK
    J Invest Dermatol 120:895-904. 2003
    The continuously remodeled hair follicle is a uniquely exploitable epithelial-mesenchymal interaction system...
  35. pmc Hair loss and defective T- and B-cell function in mice lacking ORAI1
    Yousang Gwack
    Department of Pathology, Harvard Medical School and the Immune Disease Institute, Rm 152, Warren Alpert Bldg, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell Biol 28:5209-22. 2008
    ..Orai1(-/-) mice were small in size, with eyelid irritation and sporadic hair loss resembling the cyclical alopecia observed in mice with keratinocyte-specific deletion of the Cnb1 gene...
  36. ncbi Towards a molecular understanding of hair loss and its treatment
    G Cotsarelis
    Department of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, M8 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104, USA
    Trends Mol Med 7:293-301. 2001
    Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes...
  37. pmc Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration
    Maksim V Plikus
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Nature 451:340-4. 2008
    ..b>Hair stem cells located in the follicle bulge are regulated by the surrounding microenvironment, or niche...
  38. ncbi Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Development 131:2257-68. 2004
    ..thought to perform multiple functions in the regulation of skin appendage morphogenesis and the postnatal growth of hair follicles. However, definitive genetic evidence for these roles has been lacking...
  39. pmc Laminin-10 is crucial for hair morphogenesis
    Jie Li
    Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Room 2145, CA 94305, USA
    EMBO J 22:2400-10. 2003
    ..Here, we describe the essential role of laminin-10 (alpha5beta1gamma1) in hair follicle development...
  40. pmc Wnt signaling maintains the hair-inducing activity of the dermal papilla
    J Kishimoto
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 14:1181-5. 2000
    The formation of the hair follicle and its cyclical growth, quiescence, and regeneration depend on reciprocal signaling between its epidermal and dermal components...
  41. ncbi Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study
    Gary J Myers
    Department of Neurology, National Institute for Child Health and Development, National Institutes of Health, Department of Health and Human Services, Bethesda, USA
    Lancet 361:1686-92. 2003
    ..The most common form of prenatal exposure is maternal fish consumption, but whether such exposure harms the fetus is unknown. We aimed to identify adverse neurodevelopmental effects in a fish-consuming population...
  42. pmc Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways
    Petra Clara Arck
    Department of Internal Medicine, Charite School of Medicine, Humboldt University, Berlin, Germany
    Am J Pathol 162:803-14. 2003
    It has been much disputed whether or not stress can cause hair loss (telogen effluvium) in a clinically relevant manner...
  43. doi Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells
    Trond Aasen
    Center of Regenerative Medicine in Barcelona, Barcelona, Spain
    Nat Protoc 5:371-82. 2010
    ..human keratinocytes from foreskin samples and punch biopsies, as well as how to isolate keratinocytes from plucked hair. We further describe culture techniques and approaches to efficiently infect and reprogram these cells for the ..
  44. pmc A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs
    Fernando Barbosa
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Environ Health Perspect 113:1669-74. 2005
    ..both external and endogenous Pb exposure, past or recent exposure, as well as the significance of Pb determinations in human specimens including hair, nails, saliva, bone, blood (plasma, whole blood), urine, feces, and exfoliated teeth.
  45. ncbi Isolation of murine hair-inducing cells using the cell surface marker prominin-1/CD133
    Yuriko Ito
    Department of Tissue Regeneration, Research Institute, International Medical Center of Japan, Toyama, Shinjuku, Tokyo, Japan
    J Invest Dermatol 127:1052-60. 2007
    b>Hair is a mini-organ in which dermal papilla (DP) cells play important roles in hair follicle morphogenesis and formation via interactions with epithelial cells...
  46. ncbi p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
    Johanna Laurikkala
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 133:1553-63. 2006
    ..factor of the p53 family, result in abnormal morphogenesis of the skin and its associated structures, including hair follicles and teeth...
  47. ncbi Mercury pollution and childhood in Amazon riverside villages
    M C N Pinheiro
    Nucleo de Medicina Tropical, Universidade Federal do Para, Av Generalíssimo Deodoro, 92 Umarizal, 66055 240 Belém, PA, Brazil
    Environ Int 33:56-61. 2007
    ..A total of 168 children were analyzed to find possible correlations between gender, age, location, and hair mercury content. For each location, no statistically significant differences (P<0...
  48. pmc Scratching the surface of skin development
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA
    Nature 445:834-42. 2007
    ..that instruct them to commit to a particular differentiation programme and generate a stratified epidermis, hair follicles or sebaceous glands...
  49. ncbi Miz1 is required for hair follicle structure and hair morphogenesis
    Anneli Gebhardt
    Institute for Cell Biology, University of Marburg, Robert Koch Str 6, 35033 Marburg, Germany
    J Cell Sci 120:2586-93. 2007
    ..Miz1 is expressed in basal keratinocytes of the interfollicular epidermis and in hair follicles...
  50. doi A comparison of Toxocara canis embryonation under controlled conditions in soil and hair
    J Devoy Keegan
    Parasitology Research Group, Department of Zoology, University of Dublin, Trinity College, Dublin 2, Ireland
    J Helminthol 87:78-84. 2013
    ..We aimed to investigate whether the eggs of T. canis could embryonate in dog hair under controlled conditions of temperature and humidity and, if so, to what degree...
  51. ncbi Molecular biology of hair morphogenesis: development and cycling
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    J Exp Zool B Mol Dev Evol 298:164-80. 2003
    In mammals, hair follicles produce hairs that fulfill a number of functions including thermoregulation, collecting sensory information, protection against environmental trauma, social communication, and mimicry...
  52. pmc High levels of hair manganese in children living in the vicinity of a ferro-manganese alloy production plant
    José A Menezes-Filho
    Faculty of Pharmacy, Federal University of Bahia, Brazil
    Neurotoxicology 30:1207-13. 2009
    ..The objective of this study was to analyze hair Mn of children living in the vicinity of a ferro-manganese alloy production plant in the Great Salvador region, ..
  53. doi Prenatal and postnatal mercury exposure, breastfeeding and neurodevelopment during the first 5 years
    Rejane C Marques
    Fundação Universidade Federal de Rondônia, RO, Brasil
    Cogn Behav Neurol 22:134-41. 2009
    We evaluated the association between infant hair-Hg and Gesell schedules (GS).
  54. pmc Chronic restraint stress inhibits hair growth via substance P mediated by reactive oxygen species in mice
    Nan Liu
    Department of Clinical Psychology, Medical College of Soochow University, Suzhou, PR China
    PLoS ONE 8:e61574. 2013
    Solid evidence has demonstrated that psychoemotional stress induced alteration of hair cycle through neuropeptide substance P (SP) mediated immune response, the role of reactive oxygen species (ROS) in brain-skin-axis regulation system ..
  55. pmc Multi-layered environmental regulation on the homeostasis of stem cells: the saga of hair growth and alopecia
    Chih Chiang Chen
    Institute of Clinical Medicine and Department of Dermatology, National Yang Ming University and Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Dermatol Sci 66:3-11. 2012
    ..Here we review these environmental controls using the paradigm of hair stem cells, because to observe and analyze the growth of hair is easier due to their characteristic cyclic ..
  56. pmc A single-nucleotide polymorphism in CYP2B6 leads to >3-fold increases in efavirenz concentrations in plasma and hair among HIV-infected women
    Monica Gandhi
    Department of Medicine, University of California, San Francisco, CA, USA
    J Infect Dis 206:1453-61. 2012
    ..We analyzed numerous genetic and nongenetic factors impacting short-term and long-term exposure in a large heterogeneous population of human immunodeficiency virus (HIV)-infected women...
  57. doi Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts
    Katrin Streckfuss-Bömeke
    Department of Cardiology and Pneumology, Georg August University Gottingen, Robert Koch Str 40, 37075, Gottingen, Germany
    Eur Heart J 34:2618-29. 2013
    ....
  58. doi The correlation between smoking status of family members and concentrations of toxic trace elements in the hair of children
    Muhittin A Serdar
    Department of Clinical Biochemistry, Gulhane School of Medicine, Ankara, Turkey
    Biol Trace Elem Res 148:11-7. 2012
    b>Hair analysis is a promising tool for routine clinical screening and diagnosis of heavy metal exposure and essential trace element status in the human body...
  59. ncbi Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed
    C Perrin
    Hôpital L Pasteur, Laboratoire d Anatomie Pathologique, 30 Av voie Romaine, B P 69, 06002 Nice, Cedex 1, France
    Br J Dermatol 151:362-71. 2004
    Recently, the expression profiles of the members of the complex hair keratin family have been determined in the human anagen hair follicle. In contrast, the details of hair keratin expression in the human nail unit are poorly known.
  60. doi Dihydrotestosterone inhibits murine hair growth via the androgen receptor
    A Naito
    Biological Science Research Laboratories, Research and Development Headquarters, Lion Corporation, 100 Tajima, Odawara, Kanagawa 256 0811, Japan
    Br J Dermatol 159:300-5. 2008
    Androgens cause regression of human hair follicles in the parietofrontal scalp, but the precise mechanisms by which they do so are unknown...
  61. doi Method validation for measurement of hair nicotine level in nonsmokers
    Sung Roul Kim
    The Institute for Global Tobacco Control, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Biomed Chromatogr 23:273-9. 2009
    ..b>Hair provides a readily available matrix for assessing biomarkers of typical SHS exposure...
  62. doi Usefulness of alkaline hydrogen peroxide oxidation to analyze eumelanin and pheomelanin in various tissue samples: application to chemical analysis of human hair melanins
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Melanoma Res 24:605-13. 2011
    ..Its application to characterize eumelanin and pheomelanin in human hair shows that PTCA and TTCA serve as specific markers for eumelanin and pheomelanin, respectively, although some ..
  63. doi Eclipta alba extract with potential for hair growth promoting activity
    Kakali Datta
    Molecular Oncology Lab, Dabur Research Foundation, Sahibabad, Ghaziabad 201010, India
    J Ethnopharmacol 124:450-6. 2009
    Eclipta alba is traditionally known to potentiate hair growth promotion.
  64. pmc Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo
    Ryan R Driskell
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
    J Invest Dermatol 132:1084-93. 2012
    ..Nevertheless, spheres formed by CD133- cells did not efficiently support hair follicle formation in skin reconstitution assays...
  65. pmc Wounding mobilizes hair follicle stem cells to form tumors
    Sunny Y Wong
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:4093-8. 2011
    ..We have found that expression of an activated form of Smo by stem cells of the hair-follicle bulge and secondary hair germ does not induce robust Hh signaling or produce BCCs...
  66. ncbi Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage
    M Michel
    Laboratoire de Recherche des Grands Brûlés LOEX, Hôpital du Saint Sacrement, Quebec, Canada
    J Cell Sci 109:1017-28. 1996
    ..were also [3H]thymidine-label-retaining cells, suggesting that K19 is a marker for skin stem cells of hair follicles...
  67. ncbi Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin
    A Barel
    Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium
    Arch Dermatol Res 297:147-53. 2005
    ..The effect of ch-OSA on skin, nails and hair was investigated in a randomized, double blind, placebo-controlled study...
  68. doi Roles of MED1 in quiescence of hair follicle stem cells and maintenance of normal hair cycling
    Takeshi Nakajima
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Invest Dermatol 133:354-60. 2013
    ..and appendages of Med1(epi-/-) mice were macroscopically and microscopically normal until the second catagen of the hair cycle...
  69. pmc When whorls collide: the development of hair patterns in frizzled 6 mutant mice
    Yanshu Wang
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Development 137:4091-9. 2010
    ..In the frizzled 6 null (Fz6(-/-)) mouse the orientations of the earliest born hair follicles are uncorrelated, but over time the follicles reorient to create patterns that are characterized by a ..
  70. pmc Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors
    Carlos Clavel
    Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Cell 23:981-94. 2012
    How dermal papilla (DP) niche cells regulate hair follicle progenitors to control hair growth remains unclear...
  71. ncbi Androgen-inducible TGF-beta1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understand paradoxical effects of androgen on human hair growth
    Shigeki Inui
    Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    FASEB J 16:1967-9. 2002
    ..papilla cells (DPCs) from androgenetic alopecia (AGA) and keratinocytes (KCs) to explore the role of androgens in hair growth regulation...
  72. doi Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair
    Yutaka Shimomura
    Department of Dermatology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC15 204a, New York, New York 10032, USA
    Nat Genet 40:335-9. 2008
    The genetic determinants of hair texture in humans are largely unknown...
  73. ncbi Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13
    Nathanael D Pruett
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 279:51524-33. 2004
    Intermediate filament (IF) keratins and keratin-associated proteins (KAPs) are principal structural components of hair and encoded by members of multiple gene families...
  74. doi Comparable photoreactivity of hair melanosomes, eu- and pheomelanins at low concentrations: low melanin a risk factor for UVA damage and melanoma?
    Rachel M Haywood
    RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood, Middlesex, UK
    Photochem Photobiol 84:572-81. 2008
    ..We have shown previously that melanosomes isolated from human oriental and black cat hair, and synthetic eumelanins, are photoreactive producing superoxide at low concentrations when exposed to UVA ..
  75. ncbi Analyses of toxic metals and essential minerals in the hair of Arizona children with autism and associated conditions, and their mothers
    J B Adams
    Arizona State University, Tempe, AZ 85287 6006, USA
    Biol Trace Elem Res 110:193-209. 2006
    The objective of this study was to assess the levels of 39 toxic metals and essential minerals in hair samples of children with autism spectrum disorders and their mothers compared to controls...
  76. pmc Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface
    Julie Ann Mayer
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Pathol 173:1339-48. 2008
    Epithelial appendages, such as mammary glands and hair, arise as a result of epithelial-mesenchymal interactions...
  77. ncbi An own gender bias and the importance of hair in face recognition
    Daniel B Wright
    Psychology Department, University of Sussex, Brighton BN1 9QH, UK
    Acta Psychol (Amst) 114:101-14. 2003
    ..Encoding a person's hair is shown to account for approximately half of the own gender bias when measured using hit and false alarm rates...
  78. doi Is there a 'gut-brain-skin axis'?
    Petra Arck
    Center of Internal Medicine and Dermatology, Charite University Medicine Berlin, Berlin, Germany
    Exp Dermatol 19:401-5. 2010
    ..The latter is employed in response to stress challenge, along which neurogenic skin inflammation and hair growth inhibition is mediated...
  79. ncbi A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors
    Hiromi Kobayashi
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, Lubeck, Germany
    FASEB J 19:1710-2. 2005
    ..Here, we demonstrate melatonin-like immunoreactivity (IR) in the outer root sheath (ORS) of mouse and human hair follicles (HFs), which corresponds to melatonin, as shown by radioimmunoassay and liquid chromatography/tandem mass ..
  80. doi Contact between dermal papilla cells and dermal sheath cells enhances the ability of DPCs to induce hair growth
    Mikaru Yamao
    PhoenixBio, Higashihiroshima, Japan
    J Invest Dermatol 130:2707-18. 2010
    We previously showed that cultured rat dermal papilla cells (DPCs) retain their hair-inducing capacity on afollicular epidermal cell (EPCs)...
  81. doi Contamination of dog hair with eggs of Toxocara canis
    Gillian Roddie
    Research and Innovation Office, O Reilly Institute, Trinity College, Dublin 2, Ireland
    Vet Parasitol 152:85-93. 2008
    ..the prevalence and intensity of adult toxocaral worm infection in the intestines and eggs harboured in the hair. A novel method of washing the eggs from the hair was used. Sixty-seven percent of dogs were found to have T...
  82. ncbi Hair cycle-dependent changes of alkaline phosphatase activity in the mesenchyme and epithelium in mouse vibrissal follicles
    Machiko Iida
    Division of Resources Life Science, The United Graduate School of Agricultural Sciences, Tottori University, 4 101 Koyama Minami, Tottori 680 8553, Japan
    Dev Growth Differ 49:185-95. 2007
    ..Its localization and strength dramatically changed during the hair cycle...
  83. doi Spatial distributions of carbon, nitrogen and sulfur isotope ratios in human hair across the central United States
    Luciano O Valenzuela
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Rapid Commun Mass Spectrom 25:861-8. 2011
    We present data on the carbon (δ(13)C), nitrogen (δ(15)N) and sulfur (δ(34)S) isotope ratios of human hair collected in the central portions of the USA...
  84. pmc Infantile zinc deficiency: association with autism spectrum disorders
    Hiroshi Yasuda
    La Belle Vie Research Laboratory, Tokyo 103 0006, Japan
    Sci Rep 1:129. 2011
    ..In this study, we examine hair zinc concentrations for 1,967 children with autistic disorders (1,553 males and 414 females), and show considerable ..
  85. doi Ectodermal dysplasias: clinical and molecular review
    Atila F Visinoni
    Department of Genetics, Federal University of Parana, Curitiba, Parana, Brazil
    Am J Med Genet A 149:1980-2002. 2009
    ..characterized by alterations in two or more ectodermal structures, at least one of these involving alterations in hair, teeth, nails, or sweat glands...
  86. ncbi RET tyrosine kinase enhances hair growth in association with promotion of melanogenesis
    M Kato
    Graduate Department of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Oncogene 20:7536-41. 2001
    We first demonstrated that c-Ret protein is transiently expressed mainly in the inner and outer root sheaths of hair follicles soon after birth in the skin of normal C57BL/6 and BALB/c mice...
  87. pmc Incongruence in doping related attitudes, beliefs and opinions in the context of discordant behavioural data: in which measure do we trust?
    Andrea Petroczi
    School of Life Sciences, Kingston University London, Kingston upon Thames, Surrey, United Kingdom
    PLoS ONE 6:e18804. 2011
    ..Social psychology research on doping and outcome based evaluation of primary anti-doping prevention and intervention programmes have been dominated by self-reports. Having confidence in the validity and reliability of such data is vital...
  88. pmc Increased mortality in cartilage-hair hypoplasia
    O Makitie
    Hospital for Children and Adolescents, Helsinki University Hospital
    Arch Dis Child 84:65-67. 2001
    Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia with severe growth failure and impaired immunity. Impaired immunity may result in increased mortality.
  89. pmc Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair
    Dong Dong Wu
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, PR China
    BMC Evol Biol 8:241. 2008
    b>Hair is unique to mammals...
  90. ncbi Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla
    Kevin J McElwee
    Department of Dermatology, Philipp University, Marburg, Germany
    J Invest Dermatol 121:1267-75. 2003
    ..Dermal papiller (DP)-derived cells and cells from the peribulbar dermal sheath "cup" (DSC) induced new hair follicles in both implanted ears and footpads, while nonbulbar dermal sheath cells did not...
  91. doi Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism
    Malarveni Damodaran Lakshmi Priya
    Department of Biochemistry, Bharathi Women s College, Chennai, 600 108 Tamil Nadu, India
    Biol Trace Elem Res 142:148-58. 2011
    ..There are also studies reporting a decrease in nutritional trace elements in the hair and nail of autistic children with healthy controls; moreover, bioelements have been shown to play an important ..
  92. ncbi WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism
    Stefanie Sick
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Science 314:1447-50. 2006
    ..Here we identify WNT and its inhibitor DKK as primary determinants of murine hair follicle spacing, using a combined experimental and computational modeling approach...
  93. pmc Secondhand smoke exposure among women and children: evidence from 31 countries
    Heather Wipfli
    Institute for Global Tobacco Control, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, W6027, Baltimore, MD 21205, USA
    Am J Public Health 98:672-9. 2008
    ....
  94. doi Dietary intake and serum and hair concentrations of minerals and their relationship with serum lipids and glucose levels in hypertensive and obese patients with insulin resistance
    Joanna Suliburska
    Department of Human Nutrition and Hygiene, Life Sciences University in Poznan, Wojska Polskiego 31, PL 60 624 Poznan, Poland
    Biol Trace Elem Res 139:137-50. 2011
    ..In the present study, we sought to determine associations between serum and hair mineral concentrations and serum lipids and glucose levels...
  95. pmc Hydrogen and oxygen isotope ratios in human hair are related to geography
    James R Ehleringer
    IsoForensics, Inc, 423 Wakara Way, Suite 205, Salt Lake City, UT 84108, USA
    Proc Natl Acad Sci U S A 105:2788-93. 2008
    ..a model to predict the geographic region-of-origin of humans based on the stable isotope composition of their scalp hair. This model incorporates exchangeable and nonexchangeable hydrogen and oxygen atoms in amino acids to predict the ..
  96. pmc Loss of desmocollin 3 in mice leads to epidermal blistering
    Jiangli Chen
    Department of Dermatology, Charles C Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, CO 80045, USA
    J Cell Sci 121:2844-9. 2008
    ..the function of DSC3 in the development and maintenance of stratified epithelia, in particular the epidermis and hair follicles...
  97. doi Novel dry polymer foam electrodes for long-term EEG measurement
    Chin Teng Lin
    Department of Electrical Engineering, Institute of Imaging and Biomedical Photonics and Brain Research Center, National Chiao Tung University, Hsinchu 300, Taiwan
    IEEE Trans Biomed Eng 58:1200-7. 2011
    ..The experimental results presented that the dry foam electrode performs better for long-term EEG measurement, and is practicable for daily life applications...
  98. pmc Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
    Jing Gao
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 22:2111-24. 2008
    b>Hair morphogenesis takes place through reciprocal epithelial and mesenchymal signaling; however, the mechanisms controlling signal exchange are poorly understood...
  99. doi An assessment of cortisol analysis in hair and its clinical applications
    R Gow
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Forensic Sci Int 196:32-7. 2010
    b>Hair analyses for exogenous compounds, specifically drugs of abuse, have been a useful tool in detecting long-term drug exposure. More recently, studies have delved into the exposure of endogenous compounds in hair...
  100. pmc TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation
    Xiping Cheng
    The Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, 3089 Natural Science Building Kraus, 830 North University, Ann Arbor, MI 48109, USA
    Cell 141:331-43. 2010
    A plethora of growth factors regulate keratinocyte proliferation and differentiation that control hair morphogenesis and skin barrier formation...
  101. doi G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
    Sandra M Pasternack
    Institute of Human Genetics, University of Bonn, Bonn 53111, Germany
    Nat Genet 40:329-34. 2008
    ..is the first to implicate a G protein-coupled receptor as essential for and specific to the maintenance of human hair growth...

Research Grants76

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Blood samples will be collected. Other samples, such as saliva, tears, hair, stool, and urine, may be collected as needed. Adult participants may also provide a skin sample...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Blood samples will be collected. Other samples, such as saliva, tears, hair, stool, and urine, may be collected as needed. Adult participants may also provide a skin sample...
  3. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..Other treatment approaches target proteins involved in apoptosis which contribute to death of outer hair cells (OHCs)...
  4. Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
    Vickram Ramkumar; Fiscal Year: 2013
    ..ROS mediate damage to the outer hair cells (OHCs), stria vascularis (SV) and spiral ganglion cells (SGCs)...
  5. Targeting p53-Dependent Repigmentation in Vitiligo
    TAMARA G TERZIAN; Fiscal Year: 2013
    ..therapy for vitiligo is a classic example of regenerative medicine where activation of a stem cell population in a hair follicle niche can produce differentiated melanocytes that will repopulate the interfollicular epidermis and ..
  6. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
    ..indicate that the transplatin, an inactive isomer of cisplatin, reduces cisplatin induced death of cochlear hair cell in culture...
  7. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..burn scars) is compromised by their limited lifespan in vitro, and by anatomic deficiencies, including absence of hair, glands and nails...
  8. Mechanisms of Cochlear Oxidative Stress Injury and Strategies to Protect Hearing
    Michael J Brenner; Fiscal Year: 2013
    ..types of insults to the ear may converge on common molecular pathways to cause cochlear inflammation and ultimately hair cell death...
  9. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    Dennis G Drescher; Fiscal Year: 2013
    The overall objective of the proposal is to identify hair cell/efferent transmitters/modulators at the periphery, the receptors mediating their actions, and the basic biochemical events occurring in hair-cell synaptic transmission as ..
  10. NATIONAL CHILDREN'S STUDY - CACHE COUNTY STUDY CENTER
    Edward Clark; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and ..
  11. Human developmental toxicity of metal mixture exposure from e-waste recycling
    Aimin Chen; Fiscal Year: 2010
    ..The applicants will assess the environmental (air, dust, soil) and biological (maternal blood, urine, hair, cord blood) exposure markers of e-waste metal mixtures (Pb, Hg, Cd, Cr, Mn)...
  12. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
    ..of noise and aging shows that moderate exposures, which initially appear reversible and cause no acute or chronic hair cell loss, elicit a slow-onset loss of spiral ganglion cells (SGCs) when followed for months post-exposure...
  13. Understanding thyroid hormone regulation of neurogenesis in the cochlea
    Mirna Mustapha; Fiscal Year: 2013
    ..deficiency in the neonatal period permanently impairs neurogenesis and synapse formation with inner and outer hair cells resulting in deafness that cannot be rescued by later treatment with thyroid hormone...
  14. Visualization of ototoxic mitochondrial dysfunction in mammalian hair cells
    Shelley A Batts; Fiscal Year: 2012
    Hearing impairment is often caused by the sudden or gradual death of the cochlear hair cells, which are vulnerable to damage from noise, age, infection and toxic drugs...
  15. Klotho regulation and aging
    Gwendalyn D King; Fiscal Year: 2010
    ..humans (cognitive impairment, atherosclerosis, ectopic calcification, emphysema, osteoporosis, skin atrophy and hair loss, thymic involution, infertility and decreased bone mineral density)...
  16. Structure-function analyses on novel processes of type II vestibular hair cells
    Jennifer S Stone; Fiscal Year: 2013
    ..A major cause of balance disorders is the loss of vestibular hair cells in the inner ear, which convert head movements into electrical signals that are sent to the brain via the ..
  17. Functional characterization of the Bronx waltzer deafness gene
    Botond Banfi; Fiscal Year: 2013
    ..Histological analysis of bv mice revealed a selective loss of cochlear inner hair cells and vestibular hair cells during the perinatal period, without accompanying damage to outer hair cells...
  18. A reconstructed skin model for development of treatments for albinism
    Seth J Orlow; Fiscal Year: 2010
    ..OCA2 results in hypopigmentation of the skin, hair and eyes as well as visual deficits resulting from misrouting of the optic tract and maldevelopment of the retina...
  19. Central Biochemistry Laboratory of the CKiD Consortium
    George J Schwartz; Fiscal Year: 2013
    ..The CBL also provides the kits and instructions for collection and shipment of blood, plasma, sera, urine, hair, and nail samples to NIH repositories...
  20. Basic Mechanisms in Hearing Loss of Cochlear Origin
    Allen F Ryan; Fiscal Year: 2013
    ..Research Design: To improve our understanding of cellular processes underlying hair cell (HC) damage and loss, the contributions of molecular isoforms within known HC damage and survival pathways ..
  21. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..have been followed to age 2 years, involving the collection of extensive Pb, Mn, and As biomarker data (blood, hair, nails), providing a record of lifetime (including prenatal) exposures to these metals...
  22. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ..impaired ovulation and cysts on the ovaries that causes significant morbidity in adult women, including abnormal hair growth, acne, irregular menses, infertility, and an increased risk for diabetes, obesity and the metabolic syndrome...
  23. COCHLEAR MACROPHAGES AND EPITHELIAL REPAIR
    Keiko Hirose; Fiscal Year: 2013
    ..In prior work, we have demonstrated that hair cell injury evokes a strong, rapid recruitment of professional phagocytes in the form of monocytes and macrophages ..
  24. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..nano refers to the fact that these devices are very small, in the range of a hundredth of the thickness of human hair)...
  25. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2013
    ..by applicant): The long-term objectives are to understand the cellular mechanisms of transduction in auditory hair cells and delineate the factors underlying the cochlea's tonotopic organization...
  26. Genomic approaches to inner ear hair cell regeneration
    Michael Lovett; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Damage to inner ear hair cells is a leading cause of human deafness and balance disorders and affects >10% of the world's population. Mammals cannot regenerate their hair cells...
  27. Cicatricial Alopecia Research Symposium 2011: Lipids, Inflammation &Stem Cells
    Pratima Karnik; Fiscal Year: 2011
    ..momentum generated in the last five years has led to the planning of the current symposium that will bring together hair biologists, stem cell biologists, environmental toxicologists, immunologists, dermatologists, and hair transplant ..
  28. Core Center for BioBehavioral Sciences of Communication Disorders
    Mabel L Rice; Fiscal Year: 2013
    ..later cognitive and language development, clinical trials with a viral vector to induce regeneration of vestibular hair cells for the treatment of tinnitus/balance disorders, and gene regulation of axon growth related to cortical ..
  29. Genetics of Age-Related Hearing Loss
    Kenneth R Johnson; Fiscal Year: 2013
    ..Cdh23 encodes a component of the stereocilia tip link, which is essential to hair cell mechanotransduction, but it is unclear how the Cdh23ahl variant influences AHL...
  30. Cloning &Functional Studies of Deafness Mutations
    Kenneth R Johnson; Fiscal Year: 2013
    ..proposed functions of each gene, as they relate to such processes as inner ear development, endolymph homeostasis, hair cell morphogenesis, and mechanotransduction...
  31. ENDOGENOUS MODULATION OF COCHLEAR INJURY
    Leonard P Rybak; Fiscal Year: 2012
    ..This enzyme generates superoxide radicals that can damage outer hair cells (OHCs), leading to hearing loss. ROS can activate cochlear genes that may be protective or harmful...
  32. Skin Regeneration with Stem Cells and Scaffolds
    SUSAN RENEE OPALENIK; Fiscal Year: 2013
    ..of connective tissue architecture, including the formation of functional elastic fibers and the initiation of hair follicle formation...
  33. USHERIN: STRUCTURAL AND FUNCTIONAL ANALYSIS
    DOMINIC E COSGROVE; Fiscal Year: 2012
    ..tracheal epithelium and retinal extracts, and perform subcellular localization experiments in photoreceptors and hair cells...
  34. Diesel, Allergens and Gene Interaction and Child Atopy
    Grace LeMasters; Fiscal Year: 2009
    ..Objective measures of respiratory disease, including asthma, as well as DNA, hair samples and parental report of ETS exposures are currently being collected from the children aged seven by the ..
  35. TNF Alpha in PKC Epsilon Signaling to Carcinogenesis
    Ajit K Verma; Fiscal Year: 2013
    ..alpha (TNF1) and granulocyte colony-stimulating factor (G-CSF) which may directly promote the proliferation of hair follicle stem cells, the targets of SCC...
  36. A cell-specific inducible model of hearing loss
    Albert S Edge; Fiscal Year: 2011
    ..is to develop a genetic model in which we can induce the death of specific cell types in the cochlea including hair cells and spiral ganglion neurons, two critical cell types for hearing loss...
  37. Identifying the Atoh1 targetome in hair cells with deep sequencing
    Andrew K Groves; Fiscal Year: 2013
    ..The most common reason for hearing loss is the death of sensory hair cells in the inner ear...
  38. Klotho regulation and aging
    GWENDALYN DIANN KING; Fiscal Year: 2013
    ..humans (cognitive impairment, atherosclerosis, ectopic calcification, emphysema, osteoporosis, skin atrophy and hair loss, thymic involution, infertility and decreased bone mineral density)...
  39. MAMMALIAN POLYAMINE METABOLISM
    David J Feith; Fiscal Year: 2013
    ..First, skin sections will be analyzed to identify the developmental defects in hair follicle morphogenesis and cycling that are induced by AZ and AdoMetDC expression...
  40. The role of caspase-2 in osteoblast-osteoclast interactions
    DANIELLE ARDEN VICTOR; Fiscal Year: 2013
    ..Examples of aging-related traits seen in caspase-2 deficient mice include impaired hair regrowth ability, decreased body fat content, increased levels of protein oxidation in the liver, and importantly, ..
  41. Role of TRPM1 (Melastatin1) in the Biology of Human Melanocytes
    Vijayasaradhi Setaluri; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE Melanocytes are the source of skin and hair pigmentation...
  42. Tumor -Targeting Chemotherapeutic Agents
    Iwao Ojima; Fiscal Year: 2013
    ..very little or no specificity, which leads to systemic toxicity, causing undesirable severe side effects such as hair loss, damages to liver, kidney and bone marrow...
  43. CODING IN AUDITORY NEURONS: EFFECTS OF AMINO ACIDS
    Donald M Caspary; Fiscal Year: 2013
    ..These threshold changes are at least in part, independent of inner ear hair cell loss...
  44. Biomarkers in HPA axis and inflammatory pathways for suicidal behavior in youth
    Nadine M Melhem; Fiscal Year: 2013
    ..In this R21 pilot study, we propose to examine hair cortisol concentrations (HCC) in psychiatric inpatients, 13-25 years of age, admitted for suicide attempt (n=35) ..
  45. NATIONAL CHILDREN'S STUDY SUPPORT
    Betty Wood; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and ..
  46. NATIONAL CHILDREN'S STUDY SUPPORT
    Betty Wood; Fiscal Year: 2013
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and ..
  47. NATIONAL CHILDREN'S STUDY -CLINICAL BIOLOGICAL ANALYSIS
    VELAZQUEZ FRANCISCO; Fiscal Year: 2011
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and ..
  48. NATIONAL CHILDREN'S STUDY SUPPORT
    Betty Wood; Fiscal Year: 2011
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and ..
  49. INTRACOCHLEAR ELECTROCHEMICAL GRADIENTS
    Alexander A Spector; Fiscal Year: 2012
    ..The resulting electrochemical gradients act as a battery to power a membrane-based motor in the outer hair cell...
  50. Myosin 15:Genetics, Pathology and Therapeutic Potential
    Sally A Camper; Fiscal Year: 2013
    ..These mutants have profound congenital deafness, hair bundle pathology that is distinct from shaker 2 and shaker 2J mice, and apparently normal vestibular function...
  51. Rabies virus maintenance in bat populations
    APRIL DAWN DAVIS; Fiscal Year: 2013
    ..will be included in this proposal: big brown bats (Eptesicus fuscus), little brown bats (Myotis spp), and silver hair bats (Lasionycteris noctivagans)...
  52. Determinants of developing efferent synapses in the mammalian cochlea
    ISABELLE CATHERINA ROUX; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In the developing mammalian cochlea, the inner hair cells (IHCs) transiently and the outer hair cells (OHCs) permanently receive efferent innervation originating in the auditory brain stem...
  53. Genetics of Alopecia Areata in the C3H/HeJ Mouse
    JOHN PAUL SUNDBERG; Fiscal Year: 2013
    ..Alopecia areata (AA) is a disfiguring human autoimmune skin disease with a complex genetic basis that targets hair follicles in the actively growing anagen phase and is often associated with other systemic autoimmune diseases...
  54. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2013
    ..of neurotrophins rescues spiral ganglion (SG) neurons from degeneration resulted from the loss of cochlear hair cells...
  55. Regeneration of stereocilia of cochlear hair cells
    David Z Z He; Fiscal Year: 2010
    The senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Hair cells transduce mechanical stimuli into electrical activity...
  56. Mechanics of Inner Ear Hair Bundles
    KIRIAKI DOMENICA KARAVITAKI; Fiscal Year: 2012
    ..provided by applicant): The overall goal is to understand how sound is coupled to individual stereocilia within hair bundles of mammalian cochlea...
  57. Oocyte-derived R-spondin2 as a Follicle Stimulating Hormone
    AARON JW HSUEH; Fiscal Year: 2013
    ..secreted proteins have been found to be potent growth factors for adult stem cells in gastrointestinal organs and hair follicles by serving as co-ligands for the Wnt signaling pathway essential for cell proliferation...
  58. Preventing hair cell loss by regulating prestin's function
    Jing Zheng; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Mammals including humans need amplification by outer hair cells (OHCs) for their high sensitivity and sharp frequency selectivity...
  59. Accelerated Biologic Aging and Risk for Sepsis and Organ Failure Following Trauma
    ELIZABETH GROOMS NESMITH; Fiscal Year: 2012
    ..Chronic stress will be operationally defined by high scores on the Life Events and Difficulties Schedule and high hair cortisol...
  60. GENETIC & ENVIRONMENTAL RISK FACTORS FOR BLADDER CANCER
    Malcolm Pike; Fiscal Year: 2009
    ..b>Hair dyes represent another substantial source of arylamines in humans, and we recently showed that sustained use of ..
  61. Targeting S1P receptors to prevent hearing loss
    Jerold Chun; Fiscal Year: 2010
    Targeting S1P receptors to prevent hearing loss Cochlear hair cells, the primary functional subunits required for the transduction of vibration into the auditory sensation, are subject to irreversible degeneration and consequent loss of ..
  62. Support cell specific expression of regulatable Math-1
    David Poulsen; Fiscal Year: 2006
    b>Hair cells are the mechanosensory cells of the cochlea and may be lost as a consequence of aging or exposure to ototoxic agents and viral or bacterial pathogens...
  63. HAIR DYE USE AND RISK OF NONHODGKINS LYMPHOMA
    Tongzhang Zheng; Fiscal Year: 2000
    ..American Cancer Society and two recent case-control studies from the NCI found a strong association between dark hair dye use and risk of NHL while another recent follow-up study found no association...
  64. CELLULAR MECHANISMS OF THE VESTIBULAR SYSTEM
    Jay Goldberg; Fiscal Year: 2009
    ..is a continuing investigation of synaptic transmission in vestibular organs with particular emphasis on the type I hair cell and its calyx ending, phylogenetically recent acquisitions, only found in reptiles, birds and mammals...
  65. REGENERATION AND REINNERVATION OF VESTIBULAR HAIR CELLS
    MANNING CORREIA; Fiscal Year: 1999
    ..of the proposed research is to study the neuroelectric events that accompany immature avian (pigeon) vestibular hair cell regeneration and synaptic reinnervation of regenerated hair cells by primary afferents and efferents following ..
  66. MECHANISMS OF DRUG DEPOSITION IN HAIR
    JAMES RUTH; Fiscal Year: 2002
    ..b>Hair testing has the potential to offer numerous advantages over urine and serum testing; some of those being 1) reduced ..
  67. Gene-Expression Patterns During Hair-Cell Regeneration
    ALBERT JAMES HUDSPETH; Fiscal Year: 2010
    ..The specific Challenge Topic is 11-DC-101, Hair Cell Regeneration and Maintenance...
  68. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..Our recent results suggest that the hair follicle is a promising source for such stem cells...
  69. FUNCTION OF NOGGIN IN HAIR FOLLICLE GROWTH AND DISEASE
    Vladimir Botchkarev; Fiscal Year: 2006
    Despite different pathogenic mechanisms, most common hair growth disorders (androgenic alopecia and alopecia areata) are characterized by the development of hair follicle miniaturization with significant elongation of the resting stage, ..
  70. HAIR CELL REGENERATION IN THE VESTIBULAR OTOLITH ORGANS
    Richard Baird; Fiscal Year: 2001
    DESCRIPTION: Preliminary in vivo and in vitro studies have demonstrated that hair cell regeneration in the bullfrog vestibular otolith organs following gentamicin ototoxicity is accomplished via both mitotic and non-mitotic mechanisms...
  71. Hair Cell Regeneration in the Mature Mammalian Cochlea
    Yehoash Raphael; Fiscal Year: 2009
    Sensorineural hearing loss is most commonly a result of hair cell degeneration. Hair cells in the organ of Corti cannot be replaced once lost, and therefore, sensorineural hearing loss is permanent...
  72. A ROLE FOR NOGGIN AND BMP2/4 IN HAIR GROWTH CONTROL
    Vladimir Botchkarev; Fiscal Year: 2003
    Background: Despite different pathogenic mechanisms, two of the most common hair growth disorder (androgenic alopecia and alopecia areata) are characterized by hair follicle miniaturization with significant elongation of the resting stage,..
  73. Vestibular Hair Cell Regeneration
    LARRY HOFFMAN; Fiscal Year: 2007
    ..the morphological, physiological and molecular mechanisms of recovery of the horizontal crista vestibularis hair cells following surgical intraotic administration of gentamicin (GM) in the inner ear of adult chinchillas, a well ..
  74. The Production and Dissipation of Energy in the Hair Bundle of the Inner Ear
    ADRIA CLAIRE LEBOEUF; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The hair bundle, the mechanosensitive organelle of the hair cells of the inner ear, shows evidence of a remarkable battle between evolution and physical limitations...