reticuloendothelial system

Summary

Top Publications

  1. ncbi Biliary obstruction reduces hepatic killing and phagocytic clearance of circulating microorganisms in rats
    Sumito Hoshino
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Gastrointest Surg 7:497-506. 2003
  2. ncbi Targeting study of gelatin adsorbed clodronate in reticuloendothelial system and its potential application in immune thrombocytopenic purpura of rat model
    Peiyong Li
    Department of Nuclear Medicine, Rui Jin Hospital Affiliated to Shanghai Second Medical University, Ruijin 2nd Road 197, Shanghai 200025, PR China
    J Control Release 114:202-8. 2006
  3. ncbi Autoimmune thrombocytopenia: flow cytometric determination of platelet-associated CD154/CD40L and CD40 on peripheral blood T and B lymphocytes
    Mohamed H Meabed
    Department of Pediatrics, Faculty of Medicine, Bani Suef University, Bani Suef, Egypt
    Hematology 12:301-7. 2007
  4. ncbi Iron metabolism in the reticuloendothelial system
    Mitchell Knutson
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Crit Rev Biochem Mol Biol 38:61-88. 2003
  5. pmc The adaptive response of the reticuloendothelial system to major liver resection in humans
    Martin J Schindl
    Edinburgh Liver Surgery and Transplantation Experimental Research Group eLISTER and the Department of Surgery, Royal Infirmary Edinburgh, University of Edinburgh, Edinburgh, United Kingdom
    Ann Surg 243:507-14. 2006
  6. pmc Adenovirus-platelet interaction in blood causes virus sequestration to the reticuloendothelial system of the liver
    Daniel Stone
    Division of Medical Genetics, Department of Medicine, University of Washington, Box 357720, Seattle, WA 98195, USA
    J Virol 81:4866-71. 2007
  7. ncbi Hepatic reticuloendothelial system dysfunction after ischemia-reperfusion: role of P-selectin-mediated neutrophil accumulation
    Nobuaki Sakamoto
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Liver Transpl 9:940-8. 2003
  8. ncbi Gut barrier permeability, reticuloendothelial system function and protease inhibitor levels following intestinal ischaemia and reperfusion--effects of pretreatment with N-acetyl-L-cysteine and indomethacin
    Z Sun
    Department of Surgery, Lund University Hospital, Lund, Sweden
    Dig Liver Dis 34:560-9. 2002
  9. ncbi Intestinal uptake and biodistribution of novel polymeric micelles after oral administration
    Frédéric Mathot
    Universite Catholique de Louvain, Department of Pharmaceutical Technology, Avenue E Mounier 73 UCL 73 20, 1200 Brussels, Belgium
    J Control Release 111:47-55. 2006
  10. ncbi Lactobacilli attenuate bacteremia and endotoxemia associated with severe intra-abdominal infection
    Henrik Thorlacius
    Department of Surgery, Malmo University Hospital, Malmo, Sweden
    Surgery 134:467-73. 2003

Detail Information

Publications231 found, 100 shown here

  1. ncbi Biliary obstruction reduces hepatic killing and phagocytic clearance of circulating microorganisms in rats
    Sumito Hoshino
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Gastrointest Surg 7:497-506. 2003
    ..This is thought to be related, in part, to dysfunction of the hepatic reticuloendothelial system (RES)...
  2. ncbi Targeting study of gelatin adsorbed clodronate in reticuloendothelial system and its potential application in immune thrombocytopenic purpura of rat model
    Peiyong Li
    Department of Nuclear Medicine, Rui Jin Hospital Affiliated to Shanghai Second Medical University, Ruijin 2nd Road 197, Shanghai 200025, PR China
    J Control Release 114:202-8. 2006
    ..Our preliminary data demonstrate that CLOD-GNS can effectively target reticuloendothelial system and its potentials in the treatment of ITP warrants further study.
  3. ncbi Autoimmune thrombocytopenia: flow cytometric determination of platelet-associated CD154/CD40L and CD40 on peripheral blood T and B lymphocytes
    Mohamed H Meabed
    Department of Pediatrics, Faculty of Medicine, Bani Suef University, Bani Suef, Egypt
    Hematology 12:301-7. 2007
    ..anti-platelet autoantibodies, which bind to circulating platelets resulting in their destruction by the reticuloendothelial system. Despite its clinical importance, the diagnosis of ITP is one of exclusion, thus, inevitably associated ..
  4. ncbi Iron metabolism in the reticuloendothelial system
    Mitchell Knutson
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Crit Rev Biochem Mol Biol 38:61-88. 2003
    Comprised mainly of monocytes and tissue macrophages, the reticuloendothelial system (RES) plays two major roles in iron metabolism: it recycles iron from senescent red blood cells and it serves as a large storage depot for excess iron...
  5. pmc The adaptive response of the reticuloendothelial system to major liver resection in humans
    Martin J Schindl
    Edinburgh Liver Surgery and Transplantation Experimental Research Group eLISTER and the Department of Surgery, Royal Infirmary Edinburgh, University of Edinburgh, Edinburgh, United Kingdom
    Ann Surg 243:507-14. 2006
    To evaluate the contribution of the liver to total circulatory reticuloendothelial system (RES) phagocytosis capacity in patients undergoing liver resection and to compare it with values in end-stage chronic liver disease.
  6. pmc Adenovirus-platelet interaction in blood causes virus sequestration to the reticuloendothelial system of the liver
    Daniel Stone
    Division of Medical Genetics, Department of Medicine, University of Washington, Box 357720, Seattle, WA 98195, USA
    J Virol 81:4866-71. 2007
    ..Identification of this new sequestration mechanism and construction of vectors that avoid it could improve levels of target cell transduction at lower vector doses...
  7. ncbi Hepatic reticuloendothelial system dysfunction after ischemia-reperfusion: role of P-selectin-mediated neutrophil accumulation
    Nobuaki Sakamoto
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Liver Transpl 9:940-8. 2003
    ..Although alterations in reticuloendothelial system (RES) function (specifically Kupffer cell function) after I-R have been delineated, the degree to which ..
  8. ncbi Gut barrier permeability, reticuloendothelial system function and protease inhibitor levels following intestinal ischaemia and reperfusion--effects of pretreatment with N-acetyl-L-cysteine and indomethacin
    Z Sun
    Department of Surgery, Lund University Hospital, Lund, Sweden
    Dig Liver Dis 34:560-9. 2002
    ..Pathophysiological mechanisms and ways to intervene on intestinal barrier dysfunction following small intestinal ischaemia and prolonged reperfusion are still not fully clarified...
  9. ncbi Intestinal uptake and biodistribution of novel polymeric micelles after oral administration
    Frédéric Mathot
    Universite Catholique de Louvain, Department of Pharmaceutical Technology, Avenue E Mounier 73 UCL 73 20, 1200 Brussels, Belgium
    J Control Release 111:47-55. 2006
    ..The oral bioavailability of the polymer was 40%. Polymeric micelles based on mmePEG750P(CL-co-TMC) showed very low clearance by the reticuloendothelial system (RES) and a renal excretion. A sustained release of risperidone was observed.
  10. ncbi Lactobacilli attenuate bacteremia and endotoxemia associated with severe intra-abdominal infection
    Henrik Thorlacius
    Department of Surgery, Malmo University Hospital, Malmo, Sweden
    Surgery 134:467-73. 2003
    ..In this study, we wanted to compare the protective effect of enteral administration of lactobacilli to gentamicin against severe intra-abdominal infection...
  11. ncbi Pathological consequences to reticuloendothelial system organs following infusion of unstable all-in-one mixtures in rats
    David F Driscoll
    Department of Medicine, Division of Clinical Nutrition, Beth Israel Deaconess Medical Center BIDMC, Harvard Medical School, Boston, MA, USA
    Clin Nutr 25:842-50. 2006
    ..Recent evidence of lung injury from the infusion of unstable lipid injectable emulsions as all-in-one mixtures (AIOs) was shown in a guinea pig infusion model...
  12. ncbi Objectives and mechanism of iron chelation therapy
    Chaim Hershko
    Department of Hematology, Shaare Zedek Medical Center, P O Box 3235, Jerusalem, Israel
    Ann N Y Acad Sci 1054:124-35. 2005
    ..The efficacy of combined chelation treatment is additive and offers an increased likelihood of success in patients previously failing DFO or deferiprone monotherapy...
  13. ncbi Temporal effect of hemoglobin resuscitation on sepsis survival
    H W Kim
    Brown University School of Medicine The Miriam Hospital, 164 Summit Avenue, Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 32:401-11. 2004
    ..In conclusion, HS resuscitation does not appear to enhance postresuscitation sepsis mortality. Rather, when conducted concomitantly or prior to sepsis, HS resuscitation appears to improve survival from a subsequent sepsis challenge...
  14. ncbi Prolonged circulation of large polymeric nanoparticles by non-covalent adsorption on erythrocytes
    Elizabeth Chambers
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Control Release 100:111-9. 2004
    ..delivery vehicles; however, their applications are limited by rapid clearance from circulation by the reticuloendothelial system (RES)...
  15. ncbi Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo
    Hiroto Hatakeyama
    Laboratory for Molecular Design of Pharmaceutics, Graduate School of Pharmaceutics, Hokkaido University, Sapporo, 060 0812, Japan
    Int J Pharm 281:25-33. 2004
    ..Collectively, these results indicate that size dependency in the uptake of Tf-PEG-L is tissue-dependent and therefore, controlling the size of Tf-PEG-L may be useful for the success of tissue targeting...
  16. ncbi Immunostimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus pyrethrum, Alpinia galanga and Citrullus colocynthis
    D Bendjeddou
    Department of Biology, Faculty of Sciences, Mentouri University, Constantine 25000, Algeria
    J Ethnopharmacol 88:155-60. 2003
    ..While the extract of Citrullus colocynthis showed much weaker and variable immunostimulating activity...
  17. ncbi Scavenger receptor block as strategy for the identification of bone marrow homing phages by panning in vivo random peptide phage displayed libraries
    Anita N Finger
    Gene Therapy Laboratory, Department of Clinical Research and Department of Urology, University of Bern, Sahli Haus 2, Inselspital, Bern, Switzerland
    J Immunol Methods 264:173-86. 2002
    ..Accordingly, this panning strategy in vivo may be useful for the identification of targeting motifs specific for cells located in the extravascular space of various tissues...
  18. ncbi AI-700 pharmacokinetics, tissue distribution and exhaled elimination kinetics in rats
    Julie A Straub
    Acusphere, Inc, Watertown, MA 02472, USA
    Int J Pharm 328:35-41. 2007
    ..At 1440 min post-dose, 52-72% of the Pd dose was recovered from organs of the reticuloendothelial system. Approximately 77% of the intravenously injected DFB was found in expired air within 3h after dosing, ..
  19. ncbi RES function and liver microcirculation in the early stage of acute experimental pancreatitis
    B Forgacs
    Department of Surgery II, Semmelweis Medical University, Budapest, Hungary
    Hepatogastroenterology 50:861-6. 2003
    The reticuloendothelial system and in particular the Kupffer cells in the liver are important for eliminating antigens and toxic substances in many diseases including acute pancreatitis...
  20. ncbi Thiazolidinediones increase the number of platelets in immune thrombocytopenic purpura mice via inhibition of phagocytic activity of the reticulo-endothelial system
    Keizo Kasono
    Department of Endocrinology and Metabolism, Jichi Medical School, Omiya Medical Center, 1 847 Amanuma cho, Saitama 330 8503, Japan
    Life Sci 71:2037-52. 2002
    ..These results suggest that TZDs improve platelet counts in this mouse model mainly by suppressing systemic reticulo-endothelial phagocytic function...
  21. ncbi [Differential diagnosis of intra- and perilienal tumors by use of a RES-specific MRI contrast agent]
    Gunnar Gaffke
    Klinik und Poliklinik für Strahlenheilkunde der Charité, CampusVirchow Klinikum, Medizinische Fakultat der Humboldt Universitat zu Berlin
    Rontgenpraxis 55:192-9. 2004
    ..To describe the additional benefit in detection and differential diagnosis of peri- and intrasplenic tumors by use of an superparamagnetic iron oxide contrast agent (SPIO)...
  22. ncbi Antibody- and complement-independent phagocytotic and cytolytic activities of human macrophages toward porcine cells
    Kentaro Ide
    Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Japan
    Xenotransplantation 12:181-8. 2005
    ..To address such a possibility, phagocytotic and cytolytic activities of human macrophages toward xenogeneic porcine cells were evaluated in vitro in the absence of antibodies and complement factors...
  23. ncbi [Bioeffects of chronic exposure to radiofrequency electromagnetic fields of low intensity (standardization strategy)]
    Iu G Grigor'ev
    State Research Center Institute of Biophysics, Moscow, 123182 Rissua
    Radiats Biol Radioecol 43:501-11. 2003
    ..The changes in parameters of reproductive functions and posterity, the increase in embryo mortality were found. The standartization strategy used in the USSR and currently applied in Russia has been discussed...
  24. ncbi Acute 40 percent exchange-transfusion with hemoglobin-vesicles (HbV) suspended in recombinant human serum albumin solution: degradation of HbV and erythropoiesis in a rat spleen for 2 weeks
    Hiromi Sakai
    Advanced Research Institute for Science and Engineering, Waseda University, Tokyo, Japan
    Transfusion 46:339-47. 2006
    ..Their efficacy for acute exchange transfusion has been characterized in animal models. However subsequent profiles of recovery involving the degradation of HbV in the reticuloendothelial system (RES) and hematopoiesis remain unknown.
  25. ncbi Targeting of mannosylated liposome incorporated benzyl derivative of Penicillium nigricans derived compound MT81 to reticuloendothelial systems for the treatment of visceral leishmaniasis
    Maitreyi Mitra
    Jadavpur University, Department of Pharmaceutical Technology, Kolkata, 700 032, India
    J Drug Target 13:285-93. 2005
    ....
  26. ncbi Polyion complex micelles composed of all-trans retinoic acid and poly (ethylene glycol)-grafted-chitosan
    Young Il Jeong
    Brain Tumor Research Laboratory, The Research Institute of Medical Science, Chonnam National University Medical School, Gwangju 501 746, Republic of Korea
    J Pharm Sci 95:2348-60. 2006
    ..A migration test was performed to investigate the inhibition of tumor cell invasion in vitro. The results suggested that the polyion complex micelles was more effective at inhibiting tumor cell migration than free ATRA...
  27. ncbi Iron mobilization from transferrin and non-transferrin-bound-iron by deferiprone. Implications in the treatment of thalassemia, anemia of chronic disease, cancer and other conditions
    George J Kontoghiorghes
    Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, Cyprus
    Hemoglobin 30:183-200. 2006
    ..Deferiprone and its combinations may also have potential applications in the treatment of cancer, the anemia of chronic disease and other conditions...
  28. ncbi The effect of the host's iron status on tuberculosis
    Johan R Boelaert
    Internal Medicine, Unit of Renal and Infectious Diseases, Algemeen Ziekenhuis St Jan, Brugge, B 8000, Belgium
    J Infect Dis 195:1745-53. 2007
    ..Thus, the host's iron status may be an important yet underevaluated factor in TB prevention and therapy and in TB vaccine design...
  29. ncbi Preparation and in vitro evaluation of carrier erythrocytes for RES-targeted delivery of interferon-alpha 2b
    M Hamidi
    Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, P O Box 71345 1583, Shiraz, Iran
    Int J Pharm 341:125-33. 2007
    ..study, human erythrocytes have been loaded with interferon-alpha 2b (IFN) with the aim to benefit the reticuloendothelial system (RES) targeting potential of the carrier cells...
  30. ncbi Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days
    Hiromi Sakai
    Advanced Research Institute for Science and Engineering, Waseda University, Tokyo 169 8555, Japan
    J Pharmacol Exp Ther 311:874-84. 2004
    ..for its degradation by daily repeated infusions (DRI) of HbV, focusing on its influence on the reticuloendothelial system (RES)...
  31. ncbi Severe pulmonary pathology after intravenous administration of vectors in cirrhotic rats
    Jeffrey S Smith
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Mol Ther 9:932-41. 2004
    After an intravascular injection, adenoviral vectors are normally taken up by the reticuloendothelial system in the liver, where they rapidly trigger an innate response...
  32. ncbi The expression of src-suppressed C kinase substrate (SSeCKS) and uptake of exogenous particles in endothelial and reticular cells
    Tilladit Rung-ruangkijkrai
    Laboratories of Anatomy, Department of Biomedical Sciences, Hokkaido University Graduate School of Veterinary Medicine, Sapporo, Japan
    Arch Histol Cytol 67:135-47. 2004
    ..Taken together, these findings indicate that SSeCKS expression in endothelial cells and reticular cells is a functional index of the reticulo-endothelial system and is involved in the uptake of particles from blood and lymph circulation...
  33. ncbi Multiple hepatic receptors cooperate to eliminate secretory mucins aberrantly entering the bloodstream: are circulating cancer mucins the "tip of the iceberg"?
    Mark G Wahrenbrock
    Glycobiology Research and Training Center, Department of Medicine, University of California, San Diego, California 92093 0687, USA
    Cancer Res 66:2433-41. 2006
    ..quot; Such aberrantly circulating mucins could play pathologic roles not only in cancer but also during injury or inflammation of hollow organs and in liver disease...
  34. ncbi Lack of recognition of Nepsilon-(carboxymethyl)lysine by the mouse liver reticulo-endothelial system: implications for pathophysiology
    Dmitri N Svistounov
    Department of Experimental Pathology, Medical Faculty, University of Tromsoe, Norway
    Biochem Biophys Res Commun 309:786-91. 2003
    ..Our results suggest that CML does not engender AGE-BSA clearance. Macromolecules substituted with CML only may escape elimination and cause pathological effects...
  35. ncbi Hepatic reticuloendothelial function during parenteral nutrition including an MCT/LCT or LCT emulsion after liver transplantation - a double-blind study
    Ernst R Kuse
    Hanover Medical Center, Abdominal and Transplant Surgery, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Transpl Int 15:272-7. 2002
    It has been demonstrated that total parenteral nutrition (TPN) modulates the function of the hepatic reticuloendothelial system (RES)...
  36. pmc Nanocrystal targeting in vivo
    Maria E Akerman
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:12617-21. 2002
    ..to target specific tissues and cell types and escape from the biological particulate filter known as the reticuloendothelial system. We set out to explore the feasibility of in vivo targeting by using semiconductor quantum dots (qdots)...
  37. pmc Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    Jodie L Babitt
    Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Invest 117:1933-9. 2007
    ..These data support a role for modulators of the BMP signaling pathway in treating diseases of iron overload and anemia of chronic disease...
  38. ncbi Melatonin corrects reticuloendothelial blockade and iron status in haemodialysed patients
    Walter Labonia
    Servicio de Nefrologia, Hospital Santojanni, Buenos Aires, Argentina
    Nephrology (Carlton) 10:583-7. 2005
    ..v. iron supplementation, thus proving iron trapping in the reticuloendothelial system. Melatonin has been reported to reduce cytokine production and, in dialysis patients, to prevent ..
  39. ncbi Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3)
    Vinod Devalia
    Department of Haematology, Princess of Wales Hospital, Bridgend, United Kingdom
    Blood 100:695-7. 2002
    ..These results indicate that this extracellular cluster is functionally important for iron transport, and its disruption leads to iron overload...
  40. ncbi Physical training attenuates the stress-induced changes in rat T-lymphocyte function
    Carol Góis Leandro
    Superior School of Physical Education, Federal University of Pernambuco, Recife, Brazil
    Neuroimmunomodulation 13:105-13. 2006
    ..Moderate physical training is associated with beneficial effects on immunological functions. We investigated the effects of a moderate physical training on T-lymphocyte function in rats submitted to acute restraint stress...
  41. ncbi Potential radiopharmaceuticals labeled with titanium-45
    K Ishiwata
    Division of Radiopharmaceutical Chemistry, Tohoku University, Sendai, Japan
    Int J Rad Appl Instrum A 42:707-12. 1991
    ..radioactivity uptake in the rat liver, followed by the spleen, suggesting potential for imaging the reticuloendothelial system. Three 45TiO-complexes with diethylenetriaminepentaacetic acid, citric acid and human serum albumin ..
  42. ncbi [Protective effect of human macrophage colony-stimulating factor (hM-CSF) on fungal infection (1). In vivo effect of hM-CSF on systemic candidiasis and in vitro effect of hM-CSF on macrophages activities]
    H Fujita
    Central Research Laboratory, The Green Cross Corporation
    Kansenshogaku Zasshi 69:60-7. 1995
    ..In addition, the effects of hM-CSF on the activity of reticuloendothelial system (RES) organ and on the phagocytic activity and NBT reduction activity of mouse macrophage were also ..
  43. ncbi Immune competence in 90Sr-exposed, adult thymectomized and antilymphocyteglobulin-treated CBA mice. II. Reticuloendothelial phagocytic function and in vitro mitogen responsiveness of spleen cells
    P Bierke
    Department of Pathology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala
    Acta Oncol 29:615-21. 1990
    ..of lymphoid cells to mitogens (LPS, PHA, Con-A) and the in vivo phagocytic functioning of the reticuloendothelial system (RES), measured as the rate of clearance of 125I-albumin micro-aggregates in peripheral blood...
  44. ncbi Effects of glucan on the reticuloendothelial system and on the development of tumors in 90Sr-exposed mice
    G Walinder
    Unit of Experimental Pathology and Risk Research, Swedish University of Agricultural Sciences, Uppsala
    Acta Oncol 31:461-7. 1992
    A series of experiments was conducted to examine the effect of glucan on the reticuloendothelial system (RES) and on the development of 90Sr-induced osteosarcomas and malignant lymphomas in CBA/S mice...
  45. ncbi Malignant histiocytosis with central nervous system involvement and hepatic mucinous cystadenoma in a single patient with review of the literature
    N Colovic
    Institute of Hematology, Clinical Center of Serbia, Belgrade, Serbia
    J BUON 12:539-42. 2007
    Malignant histiocytosis is a rare neoplasm of the reticuloendothelial system characterized by neoplastic proliferation of tissue histiocytes...
  46. ncbi Hepatic failure with neonatal tissue siderosis of hemochromatotic type in an infant presenting with meconium ileus. Case report and differential diagnosis of the perinatal iron storage disorders
    C Sergi
    Institute of Pathology, Department of Neonatology, University of Heidelberg, Germany
    Pathol Res Pract 197:699-709; discussion 711-3. 2001
    ..nodules as well as hepatic and extrahepatic iron accumulation of hemochromatotic type, sparing the reticuloendothelial system. Atomic absorption spectroscopy confirmed an increase in the iron content of various organs: liver, ..
  47. ncbi Ferric carboxymaltose: a review of its use in iron-deficiency anaemia
    Katherine A Lyseng-Williamson
    Wolters Kluwer Health mid R Adis, Auckland, New Zealand, an editorial office of Wolters Kluwer Health, Philadelphia, Pennsylvania, USA
    Drugs 69:739-56. 2009
    ..hydroxide carbohydrate complex, which allows for controlled delivery of iron within the cells of the reticuloendothelial system and subsequent delivery to the iron-binding proteins ferritin and transferrin, with minimal risk of ..
  48. ncbi Altered biodistribution and incidental findings on gallium and labeled leukocyte/bone marrow scans
    Charito Love
    Division of Nuclear Medicine, St Vincent Catholic Medical Center, New York, NY 10011, USA
    Semin Nucl Med 40:271-82. 2010
    ..The normal biodistribution of technetium-labeled leukocytes includes, in addition to the reticuloendothelial system, colon, urinary tract, and occasionally gall bladder...
  49. ncbi Measurement of thorium isotopes and 228Ra in soft tissues and bones of a deceased Thorotrast patient
    J F McInroy
    Los Alamos National Laboratory, NM 87545
    Health Phys 63:54-71. 1992
    ..all of the 232Th from the original injection was retained in the body, mostly in the tissues of the reticuloendothelial system. A total of 28 kBq (0.76 microCi) of 232Th was measured in the soft tissues and bones...
  50. ncbi Clinical studies of liposome-encapsulated doxorubicin
    A Gabizon
    Department of Oncology, Hadassah University Hospital, Jerusalem, Israel
    Acta Oncol 33:779-86. 1994
    ..doxorubicin entrapped in the bilayer of phosphatidylglycerol-rich liposomes were hindered by the avid reticuloendothelial system (RES) uptake and by drug leakage from circulating liposomes...
  51. ncbi Mortality after radiological investigation with radioactive Thorotrast: a follow-up study of up to fifty years in Portugal
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
    Radiat Res 159:521-34. 2003
    ..Thorotrast is retained by the reticuloendothelial system, with a biological half-life of several hundred years, so that such patients suffer lifetime exposure to ..
  52. ncbi [Study on mechanism of onset of endogenous endotoxemia during obstructive jaundice--with special reference to involvement of biliary infection]
    T Yamaguchi
    First Department of Surgery, Kumamoto University School of Medicine, Japan
    Nihon Geka Gakkai Zasshi 89:1223-32. 1988
    ..group was also significantly higher than that of non-jaundice group in animal study, and when the reticuloendothelial system was blocked, the endotoxin positive rate in the peripheral blood showed an increasing tendency...
  53. ncbi [Neonatal hemochromatosis. A cause of liver failure in utero. Report of two cases and review of the literature]
    Enrique Gebara
    Servicio de Neonatologia, Clinica Bazterrica, Ciudad de Buenos Aires
    Arch Argent Pediatr 106:155-61. 2008
    ..liver failure of intrauterine onset associated with intra-and extra- hepatic siderosis that spares reticuloendothelial system. It is the most frequently recognized cause of liver failure in neonates...
  54. pmc Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization
    Anita Hill
    1Department of Haematology, St James University Hospital, Leeds, UK
    Haematologica 95:567-73. 2010
    ..This may be due to C3-mediated clearance of paroxysmal nocturnal hemoglobinuria red blood cells through the reticuloendothelial system.
  55. ncbi Pathogen inactivation of Leishmania donovani infantum in plasma and platelet concentrates using riboflavin and ultraviolet light
    L J Cardo
    Walter Reed Army Institute of Research, Department of Blood Research, Transfusion Medicine Branch, Silver Spring, MD 20910 7500, USA
    Vox Sang 90:85-91. 2006
    ..The intent of this study was to examine the ability of the Mirasol PRT System to kill the Leishmania parasite in human plasma and platelet concentrates...
  56. ncbi Plasma chitotriosidase activity in patients with beta-thalassemia
    R Barone
    Division of Pediatric Neurology, Institute of Pediatrics, Catania Italy
    Blood Cells Mol Dis 25:1-8. 1999
    ..of beta-globin chains synthesis resulting in unproductive erythropoiesis and enormous expansion of the reticuloendothelial system. Plasma chitotriosidase was increased to a variable extent in 13 of 70 patients with beta-thalassemia ..
  57. ncbi The transplantation of neural stem cells and predictive factors in hematopoietic recovery in irradiated mice
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, 50005 Hradec Kralove, Czech Republic
    Transfus Apher Sci 32:157-66. 2005
    ..While we presumed the presence beta-galactosidase(+) cells in the spleen, as spleen and reticuloendothelial system represent an important retaining system for different cell types, the presence of beta-galactosidase(+) ..
  58. ncbi Identification of complement activation sites in human immunodeficiency virus type-1 glycoprotein gp120
    C Susal
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
    Blood 87:2329-36. 1996
    ..subsequent opsonization may represent a mechanism for the elimination of uninfected CD4+ cells by the reticuloendothelial system, thereby enhancing the progression of HIV disease...
  59. ncbi [Investigation on the etiology of sepsis by using experimental mouse model with leukocytopenia. 3. The role of Kupffer cells in the etiology of bacteremia]
    Y Hirakata
    Department of Laboratory Medicine, Nagasaki University School of Medicine
    Kansenshogaku Zasshi 64:1037-44. 1990
    In the previous report, we showed that the reticuloendothelial system (RES), especially the liver, played an important role in the etiology of bacteremia or sepsis as the major protective system...
  60. ncbi [Experimental study for thrombocytopenic purpura therapy by targeting macrophages in liver and spleen]
    Zhong Hua Tan
    Department of Nuclear Medicine, Ruijin Hospital, The Shanghai Jiaotong University, Shanghai 200025, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:103-7. 2007
    ..diphosphonate (Cl(2)MDP)-loaded gelatin particles can induce the depletion of macrophage in reticuloendothelial system of liver and spleen or can depress the immunity of macrophage in SD rat models of immune ..
  61. ncbi Liposome-complement interactions in rat serum: implications for liposome survival studies
    D V Devine
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Biochim Biophys Acta 1191:43-51. 1994
    Serum complement opsonizes particles such as bacteria for clearance by the reticuloendothelial system. Complement has been reported to interact with liposomes and therefore may mediate the reticuloendothelial system clearance of liposomes...
  62. ncbi Evaluation of hepatic function with (99m)Tc-galactosylated serum albumin scintigraphy in patients with malaria: comparison with (99m)Tc-colloid scintigraphy and liver ultrasonography
    Sang Woo Lee
    Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Korea
    Nucl Med Commun 28:95-9. 2007
    ....
  63. ncbi Characterization and cytotoxicity of mixed polyethyleneglycol modified liposomes containing doxorubicin
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 312:83-9. 2006
    ..Liposomes, bonding peculiarly with serum protein (opsonization), are taken up by reticuloendothelial system (RES) cells in the liver and spleen...
  64. ncbi The potential of transferrin-pendant-type polyethyleneglycol liposomes encapsulating decahydrodecaborate-(10)B (GB-10) as (10)B-carriers for boron neutron capture therapy
    Shin Ichiro Masunaga
    Particle Radiation Oncology Research Laboratory, Kyoto University, Kumatori, Osaka, Japan
    Int J Radiat Oncol Biol Phys 66:1515-22. 2006
    ..To evaluate GB-10-encapsulating transferrin (TF)-pendant-type polyethyleneglycol (PEG) liposomes as tumor-targeting (10)B-carriers for boron neutron capture therapy...
  65. ncbi Utility of MRI in assessment of pituitary iron overload
    Abdul Mueed Zafar
    Medical Student, Year V, Aga Khan University Hospital, Karachi
    J Pak Med Assoc 57:475-7. 2007
    ..The main complication of beta thalassemia major is iron overload, especially in reticuloendothelial system, heart, joints and endocrine glands...
  66. ncbi From combinatorial chemistry to cancer-targeting peptides
    Olulanu H Aina
    U C Davis Cancer Center, Division of Hematology Oncology, Department of Internal Medicine, University of California Davis, 4501 X Street, Sacramento, CA 95817, USA
    Mol Pharm 4:631-51. 2007
    ..limited by the large size of the antibody (160 kd) and its relatively nonspecific binding to the reticuloendothelial system. This latter property is particularly problematic if the antibody is used as a vehicle to deliver ..
  67. ncbi Ity influences the production of IFN-gamma by murine splenocytes stimulated in vitro with Salmonella typhimurium
    L Ramarathinam
    Department of Microbiology, University of Texas Medical Branch, Galveston 77555 1019
    J Immunol 150:3965-72. 1993
    ..Expression of the resistance gene(s) results in a slower net growth of these pathogens in the reticuloendothelial system early postinfection...
  68. ncbi Polyethylene glycol-complexed cationic liposome for enhanced cellular uptake and anticancer activity
    Suk Hyun Jung
    Biomaterials Research Center, Korea Research Institute of Chemical Technology, Yuseong, Deajeon, Republic of Korea Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University, Seoul, Republic of Korea
    Int J Pharm 382:254-61. 2009
    ..shortcomings such as their relatively short blood circulation time, fast clearance from human body by reticuloendothelial system (RES) and limited intracellular uptake to target cells...
  69. ncbi Therapeutic efficacy evaluation of 111In-labeled PEGylated liposomal vinorelbine in murine colon carcinoma with multimodalities of molecular imaging
    Tong Hsien Chow
    Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan
    J Nucl Med 50:2073-81. 2009
    ..The goal of this study was to investigate the real therapeutic effectiveness of 6 mol% PEG (111)In-vinorelbine liposomes via the elevation of the radiation dosage and reduction in the concentration of chemotherapeutic agents...
  70. pmc Galactosylated streptavidin for improved clearance of biotinylated intact and F(ab')2 fragments of an anti-tumour antibody
    D Marshall
    Department of Clinical Oncology, Royal Free Hospital School of Medicine, London, UK
    Br J Cancer 71:18-24. 1995
    ..much improved tumour to blood ratios as the radioantibody is complexed and subsequently cleared via the reticuloendothelial system, although prolonged splenic uptake is a problem...
  71. ncbi Cutaneous histoplasmosis in a child with hyper-IgM
    G G Yilmaz
    Department of Pediatrics, Akdeniz University, Medical Faculty, Antalya, Turkey
    Pediatr Dermatol 12:235-8. 1995
    ..granulomatous mycosis due to Histoplasma capsulatum and characterized by a particular affinity for the reticuloendothelial system. Glabrous skin involvement in histoplasmosis is highly unusual except in patients with advanced human ..
  72. ncbi Behavior and therapeutic efficacy of beta-glucuronidase-positive mononuclear phagocytes in a murine model of mucopolysaccharidosis type VII
    B J Freeman
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 94:2142-50. 1999
    ..However, both cell types retain the ability to home to tissues rich in cells of the reticuloendothelial system after intravenous injection into MPS VII mice...
  73. ncbi Immunity to systemic Salmonella infections
    Pietro Mastroeni
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Curr Mol Med 2:393-406. 2002
    ..The control of bacterial growth in the reticuloendothelial system (RES) in the early phases of a Salmonella infection relies on the NADPH oxidase-dependent anti-microbial ..
  74. ncbi Effect of sterical stabilization on macrophage uptake in vitro and on thickness of the fixed aqueous layer of liposomes made from alkylphosphocholines
    R Zeisig
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Biochim Biophys Acta 1285:237-45. 1996
    ..using liposomes for therapeutic purposes is the fast removal from blood circulation by components of the reticuloendothelial system (RES) most likely after opsonization of the vesicles...
  75. ncbi Kinetics of radioiodinated monoclonal antibodies in the rat. Influence of tumour growth and reticuloendothelial system host modulation
    S B Holmberg
    Department of Surgery, , Sahlgrenska Hospital, Sweden
    Acta Oncol 28:699-703. 1989
    ..In tumour-bearing animals, RES stimulation with Zymosan increased the whole body, liver and blood content of 131I activity. The two tested methods of iodination gave similar results...
  76. ncbi [Experimental studies of the value of SPIO for MRI of bone marrow before and after whole body irradiation]
    H E Daldrup-Link
    Institut fur Klinische Radiologie, Westfälischen Wilhelms Universität Münster
    Rofo 173:547-53. 2001
    ..of superparamagnetic iron oxides (SPIO; Endorem) for MRI-derived quantifications of the permeability of the blood-bone marrow barrier and the phagocytic activity of reticuloendothelial system (RES) bone marrow cells before and after TBI.
  77. ncbi Use of plain radiography to optimize skeletal outcomes in children with type 1 Gaucher disease in Brazil
    Ronald M V Mota
    Department of Pediatric Orthopedics, Socor Hospital, Belo Horizonte, Brazil
    J Pediatr Orthop 27:347-50. 2007
    ..in progressive accumulation of glucosylceramide (glucocerebroside) in lysosomes of cells of the reticuloendothelial system in the spleen, liver, and marrow...
  78. ncbi Two successful vaginal births after cesarean section in a patient with Hermansky-Pudlak syndrome who was treated with 1-deamino-8-arginine-vasopression during labor
    Ronald D Beesley
    Department of Obstetrics and Gynecology, University of Vermont, Burlington, VT 05401, USA
    Mil Med 173:1048-9. 2008
    ..characterized by oculocutaneous albinism, platelet storage dysfunction, and lipofuscin deposits in the reticuloendothelial system. Patients with the disorder are at high risk for major morbidity secondary to bleeding complications...
  79. ncbi Altered immune response (humoral and delayed-type hypersensitivity reactions) to sheep red blood cells in the course of experimental filarial infections (Litomosoides carinii, Brugia malayi, Acanthocheilonema viteae) of Mastomys natalensis
    H Zahner
    Institut für Parasitologie, Justus Liebig Universitat Giessen, Federal Republic of Germany
    Parasitol Res 75:401-11. 1989
    ..The phagocytic activity of the reticuloendothelial system (RES) was controlled in vivo by the elimination of 51Cr-labelled SRBC...
  80. ncbi Effects of CpG-oligonucleotides, poly I:C and LPS on Atlantic cod scavenger endothelial cells (SEC)
    Montserrat Martin-Armas
    Department of Cell Biology and Histology, Institute of Medical Biology, University of Tromsø, N 9037, Tromsø, Norway
    Dev Comp Immunol 32:100-7. 2008
    ..from the circulation, the scavenger endothelial cells (SECs) represent an important part of the reticuloendothelial system of vertebrates...
  81. ncbi Mannan-coated gelatin nanoparticles for sustained and targeted delivery of didanosine: in vitro and in vivo evaluation
    Amandeep Kaur
    Department of Pharmaceutical Sciences, Drug Research Punjabi University, Patiala, Punjab, 147 002, India
    Acta Pharm 58:61-74. 2008
    Macrophages of the reticuloendothelial system and brain act as major reservoir for HIV because of their long term survival after HIV infection and ability to spread virus particles to bystander CD4 positive lymphocyte cells...
  82. ncbi Ineffective erythropoiesis in mutant mice with deficient pyruvate kinase activity
    Shin Aizawa
    Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan
    Exp Hematol 33:1292-8. 2005
    ..depletion in individuals with a PK deficiency and are destroyed in the microcirculation of the reticuloendothelial system, leading to extravascular hemolysis...
  83. ncbi Quantification of pegylated phospholipids decorating polymeric microcapsules of perfluorooctyl bromide by reverse phase HPLC with a charged aerosol detector
    R Díaz-López
    Univ Paris Sud, UMR CNRS 8612, IFR 141, Faculte de Pharmacie, Chatenay Malabry, France
    J Pharm Biomed Anal 48:702-7. 2008
    ..the preparation of lipid or even polymer colloidal particles to avoid recognition and clearance by the reticuloendothelial system and to increase their plasmatic half-life...
  84. ncbi Experimental study of iron effect on the liver function
    M Hasegawa
    Department of Radiology, Showa University School of Medicine, Tokyo, Japan
    Ann Nucl Med 2:27-34. 1988
    ..were evaluated by using hepatobiliary and liver scintigraphy as the index of hepatocyte function and reticuloendothelial system function, respectively...
  85. pmc Salmonella enterica serovar Gallinarum requires the Salmonella pathogenicity island 2 type III secretion system but not the Salmonella pathogenicity island 1 type III secretion system for virulence in chickens
    M A Jones
    Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom
    Infect Immun 69:5471-6. 2001
    ..Specificity of the disease is primarily at the level of the reticuloendothelial system, but few virulence factors have been described other than the requirement for an 85-kb virulence plasmid...
  86. ncbi Romiplostim management of immune thrombocytopenic purpura
    Heather J Ipema
    College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Ann Pharmacother 43:914-9. 2009
    ..To review the pharmacology, pharmacokinetics, efficacy, and safety of romiplostim, the first drug approved for use in patients with immune thrombocytopenic purpura (ITP)...
  87. ncbi Targeted systemic gene therapy and molecular imaging of cancer contribution of the vascular-targeted AAVP vector
    Amin Hajitou
    Department of Gene Therapy, Section Division of Infectious Diseases, Faculty of Medicine, Imperial College London, Wright Fleming Institute, St Mary s Campus, Norfolk Place, London, United Kingdom
    Adv Genet 69:65-82. 2010
    ..This is mainly due to undesired uptake by the liver and reticuloendothelial system, broad tropism for mammalian cells causing toxicity, and their immunogenicity...
  88. pmc Adenovirus activates complement by distinctly different mechanisms in vitro and in vivo: indirect complement activation by virions in vivo
    Jie Tian
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 83:5648-58. 2009
    ..whereas complement activation in vivo involved both classical and nonclassical pathways as well as the reticuloendothelial system. Remarkably, the entry-deficient Ad mutant ts1 was completely unable to activate complement in vivo even ..
  89. ncbi [Endotoxemia and its compensatory mechanisms in experimental liver cirrhosis]
    M Ueno
    Department of Internal Medicine, School of Medicine, Keio University
    Nihon Shokakibyo Gakkai Zasshi 87:1692-700. 1990
    ..And functional activities of the reticuloendothelial system were also examined by radioassay with 59Fe-labelled iron-chondroitin sulfate colloid and by ..
  90. ncbi Labial salivary gland involvement in neonatal hemochromatosis: a report of 2 cases and review of literature
    King Chong Chan
    Oral and Maxillofacial Pathology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:e27-30. 2008
    ..onset, in which iron deposition occurs within hepatic and extrahepatic sites without involving the reticuloendothelial system. Labial minor salivary gland biopsy has been suggested as a diagnostic adjunct in patients suspected of ..
  91. ncbi Selective impairment of protein kinase C isotypes in murine macrophage by Leishmania donovani
    S Bhattacharyya
    Department of Microbiology, Bose Institute, Calcutta, India
    Mol Cell Biochem 216:47-57. 2001
    Leishmania donovani, an obligate intracellular parasite resides and multiplies within macrophage of the reticuloendothelial system. The intracellular signalling mechanism involved in the impaired oxidative response in leishmaniasis has ..
  92. ncbi Fatal acute respiratory distress syndrome in a patient with paracoccidioidomycosis: first case report
    Gil Benard
    Laboratory of Dermatology and Immunodeficiencies, and Laboratory of Medical Mycology, Dermatology Division, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Med Mycol 48:542-5. 2010
    ..Acute/subacute presentations can be observed in children and young adults, with the reticuloendothelial system frequently involved but the lungs are usually spared or present with mild clinical or radiological ..
  93. pmc Effects of colloidal resuscitation fluids on reticuloendothelial function and resistance to infection after hemorrhage
    E A van Rijen
    North Western Injury Research Centre, University of Manchester, United Kingdom
    Clin Diagn Lab Immunol 5:543-9. 1998
    ..of three resuscitation fluids, hydroxyethyl starch (HES), Haemaccel, and fresh autologous blood, on reticuloendothelial system phagocytic and catabolic functions and resistance to infection after 40% hemorrhages in BALB/c mice were ..
  94. ncbi Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes
    K J Harrington
    Oncology Unit, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, United Kingdom
    Clin Cancer Res 7:243-54. 2001
    ..In addition, significant localization of the liposomes was seen in the tissues of the reticuloendothelial system (liver, spleen, and bone marrow)...
  95. ncbi Scrutinizing the mechanisms underlying the induction of anemia of inflammation through GPI-mediated modulation of macrophage activation in a model of African trypanosomiasis
    Benoit Stijlemans
    Department of Molecular and Cellular Interactions, VIB, 1050 Brussel, Belgium
    Microbes Infect 12:389-99. 2010
    ..anemia of inflammation, involving a skewed iron homeostasis leading to iron accumulation within the reticuloendothelial system. Myeloid cells (M cells) have been implicated in the induction and maintenance of this type of anemia ..
  96. ncbi Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue
    Yukari Hagiwara
    Department of Oral Biology, Immunobiology Vaccine Center, University of Alabama, 845 19th Street South, Birmingham, AL 35294, USA
    J Immunol 170:1754-62. 2003
    ....
  97. ncbi Diagnosis of prion diseases
    Eric Kübler
    Prionics AG, Schlieren, Switzerland
    Br Med Bull 66:267-79. 2003
    ..In this report, we review the classical diagnostic methods as well as present and future tools for the diagnosis of prion diseases...
  98. ncbi First soluble M@C60 derivatives provide enhanced access to metallofullerenes and permit in vivo evaluation of Gd@C60[C(COOH)2]10 as a MRI contrast agent
    Robert D Bolskar
    TDA Research Inc, 12345 West 52nd Avenue, Wheat Ridge, Colorado 80033, USA
    J Am Chem Soc 125:5471-8. 2003
    ..MRI biodistribution study in a rodent model reveals Gd@C(60)[C(COOH)(2)](10) to possess the first non-reticuloendothelial system (RES) localizing behavior for a water-soluble endohedral metallofullerene species, consistent with its ..
  99. ncbi Bacillus Calmette-Guérin immunotherapy for genitourinary cancer
    Nilay M Gandhi
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21201, USA
    BJU Int 112:288-97. 2013
    ..BCG is a nonspecific stimulant to the reticuloendothelial system and induces a local inflammatory response with the infiltration of granulocytes followed by macrophages ..
  100. ncbi A comparative study on the histological structure of the spleen in the ostrich (Struthio camelus), the kestrel (Falco tinnunculus) and the osprey (Pandion haliaetus)
    Tolunay Kozlu
    Department of Histology and Embryology, Mustafa Kemal University, Hatay Turkey
    Acta Biol Hung 62:113-21. 2011
    ..and functionally belongs to the hematopoietic organs and is also an important component of the reticuloendothelial system, which is known to play a major role in host defense...
  101. pmc Precise quantification of nanoparticle internalization
    Claudia Gottstein
    Department of Chemical Engineering and California NanoSystems Institute, University of California Santa Barbara, Santa Barbara, California 93106 6105, USA
    ACS Nano 7:4933-45. 2013
    ..applied to measure the impact of surface coatings of vesosomes on their internalization by cells of the reticuloendothelial system (RES)...

Research Grants62

  1. Improved Peptide-based Tumor Targeting Agents Using Phage Display
    Susan L Deutscher; Fiscal Year: 2010
    ..peptides that are rapidly excreted in the urine and not retained in the kidneys or cleared through the reticuloendothelial system. These peptide sequences will be appended to tumor-targeting peptides and examined for their abilities ..
  2. Mechanically Stable Blood Substitutes
    Andre Francis Palmer; Fiscal Year: 2010
    ..This feature reduces recognition of these liposomes by the reticuloendothelial system (RES)...
  3. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    ..cannot respond adequately to this demand due to impaired erythropoiesis and impaired mobilization of reticuloendothelial system iron stores...
  4. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ..Within the reticuloendothelial system, macrophages (M&s) play a major role in the recycling of heme-iron via phagocytosis of senescent red ..
  5. Modifiers of hepcidin expression as new therapies for iron overload
    PAULA GOODMAN FRAENKEL; Fiscal Year: 2013
    ..therapy in thalassemia by reducing dietary iron absorption and promoting storage of iron in the reticuloendothelial system and could eliminate the need for phlebotomy treatment in patients with hemochromatosis...
  6. Pharmacology of Antiretroviral Nanoparticle Micelles
    Christopher J Destache; Fiscal Year: 2010
    ..The nanoformulations will be used as a drug delivery system to improve tissue penetrance of ART into the reticuloendothelial system (RES;spleen, liver, lymph nodes) in mice...
  7. Biomimetic Approach to the Fabrication of Red Blood Cell Mimics
    Joseph M DeSimone; Fiscal Year: 2010
    ..to conjugate "markers of self" onto these deformable molded RBC mimics to minimize elimination by the reticuloendothelial system (RES)...
  8. Phospholipid Nanocarriers Improve Chemotherapy by Targeted Drug Delivery
    Hayat Onyuksel; Fiscal Year: 2010
    ..The presence of a hydrophilic polymer (PEG) on the micelle surface reduces reticuloendothelial system (RES) uptake resulting in longer circulation of these nanocarriers...
  9. Acute vs. delayed iron therapy: effect on iron status, anemia and cognition
    Chandy C John; Fiscal Year: 2013
    ..leads to changes in iron metabolism (reduced intestinal iron absorption, iron trapping in the reticuloendothelial system) that can persist for >2 weeks, potentially reducing the efficacy of oral iron supplements^'^...
  10. NanoART Manufacture, Delivery and Pharmacokinetics for Optimizing Drug Adherence
    Howard E Gendelman; Fiscal Year: 2013
    ..a single intravenous dose of the nanoART can elicit high-sustained tissue and plasma drug levels in the reticuloendothelial system and brain...
  11. Targeted Polymer Micelles for Treatment of Metastatic Melanoma
    Kevin N Sill; Fiscal Year: 2013
    ..g. reticuloendothelial system (RES) uptake), and deliver drugs in response to a physiological stimuli encountered in solid tumor ..
  12. Conjugation of polysialic acid to biologics in glycoengineered Escherichia coli
    ADAM CHARLES FISHER; Fiscal Year: 2010
    ..is often compromised by limitations arising from proteolytic degradation, uptake by cells of the reticuloendothelial system, renal removal, and immunocomplex formation...
  13. Cytosolic sensing of intracellular Brucella infection
    Renee M Tsolis; Fiscal Year: 2013
    ..of the disease is its protracted nature that results from persistent bacterial colonization of the reticuloendothelial system and systemic dissemination...
  14. Murine Models of Heme Metabolism and Iron Recycling
    Mark D Fleming; Fiscal Year: 2013
    ..billion RBCs each day (5 million/sec) derives from recycling of heme-iron from aged RBCs catabolized by reticuloendothelial system (RES) macrophages;at steady state, dietary heme and non-heme iron absorption contribute only 1-2 mg/day ..
  15. Carbon Nanotubes as Multi-functional Spectroscopic Markers and Delivery Agents fo
    Hongjie Dai; Fiscal Year: 2012
    ..SWNTs are non-toxic when administered intravenously at high doses. Nanotubes retained in the reticuloendothelial system (RES) and are gradually excreted out of the body via the biliary and renal pathways...
  16. Iron oxide nanoparticle probes for target specific MR molecular imaging
    Y Andrew Wang; Fiscal Year: 2010
    ..Such phenomenon is vastly different from all literature reported results as all of them have high reticuloendothelial system (RES) uptake in the liver and spleen and none of them has renal clearance due to the relatively large ..
  17. A Suite of Tumor Targeting Peptides for Personalized Therapy of Lung Cancer
    Kathlynn C Brown; Fiscal Year: 2013
    ..level of liposome delivery to the tumor while minimizing uptake in other tissues and clearance by the reticuloendothelial system (RES)...
  18. Optical Imaging of Chemotherapy for Brain Tumors
    Shailendra Joshi; Fiscal Year: 2013
    ..of liposomes and nanoparticles, by the high- capacity/high affinity clearance mechanisms - mainly in the reticuloendothelial system that has prevented the development of effective liposome-based therapeutics since the late 1970's...
  19. Role of Physical Properties in Pharmacokinetics, Biodistribution and Tumor Uptake
    ISAAC MORRIS ADJEI; Fiscal Year: 2012
    ..lactic-co-glycolic acid)(PLGA) nanoparticles (NP) is hampered by their rapid clearance by cells of the reticuloendothelial system (RES). Clearance by the RES is influenced by the physical properties of the NP...
  20. Novel Magneto-Electric Nanodelivery of Drugs to Eradicate HIV from CNS
    Madhavan P Nair; Fiscal Year: 2013
    ..suffer from the lack of adequate transendothelial penetration before the drugs are engulfed by the reticuloendothelial system (RES) cells as well as the uncertainty of drug release from the carrier if and when the nanocarrier ..
  21. Manganese Transport and Toxicity
    Marianne Wessling-Resnick; Fiscal Year: 2013
    ..While ferroportin function in iron export by intestinal enterocytes and macrophages of the reticuloendothelial system has been established, its activity has yet-to-be fully explored in hepatocytes where the exporter also ..
  22. CpG-ODN Coated Hollow Gold Nanoshells for Photothermal Therapy
    Aaron E Foster; Fiscal Year: 2013
    ..for co- delivery of therapeutic agents that target MDSCs and other cellular constituents of the reticuloendothelial system, including antigen presenting dendritic cells (DCs)...
  23. Center of Nanotechnology for Treatment, Understanding, *
    SADIK ESENER; Fiscal Year: 2010
    ..Our goal is the development, of a multi-functional "smart mothership" platform that will: (1) evade the reticuloendothelial system and immune system, while attaching specifically to the tumor and its vasculature;(2) assemble a multi-..
  24. ALCOHOL AND LIVER ENDOTHELIAL CELLS IN IMMUNE RESPONSES
    Geoffrey Thiele; Fiscal Year: 1999
    ..a variety of macromolecules, thereby diminishing their important function as scavengers in the hepatic reticuloendothelial system. Additionally, liver endothelial cells play a role in the clearance of acetaldehyde modified proteins ..
  25. Nanocage System for Endoscopic Imaging and Staging of Pancreatic Cancer
    Stanislav Y Emelianov; Fiscal Year: 2010
    ..This nanocage will be shielded from the reticuloendothelial system by attachment of poly(ethylene glycol) (PEG) chains to the exterior...
  26. Characterization of the Brucella virB locus
    Renee M Tsolis; Fiscal Year: 2010
    ..An important aspect of B. abortus infection is its ability to persist within phagocytic cells of the reticuloendothelial system. We have shown that the virB locus, encoding a Type IV secretion system (T4SS), is essential for ..
  27. Brucella Type IV secretion and innate immunity
    Renee M Tsolis; Fiscal Year: 2011
    ..An important aspect of Brucella infection is its ability to persist within phagocytic cells of the reticuloendothelial system. We have shown that the virB locus, encoding a Type IV secretion system (T4SS), is essential for ..
  28. ANTIVIRAL DRUG DELIVERY WITH LYOPHILIZED PLATELETS
    Thomas Fischer; Fiscal Year: 2004
    ..strategy is to use rehydrated, lyophilized (RL) platelets to deliver ribavirin to the macrophages of the reticuloendothelial system (RES) that are involved in the initial stage of viral infection, as well as macrophages at sites of ..
  29. Micellar VIP Nanoparticles for Rheumatoid Arthritis
    Israel Rubinstein; Fiscal Year: 2007
    ..PEG molecules grafted on the surface of micelles confer steric hindrance thereby evading uptake by the reticuloendothelial system. Consequently, the dose of VIP required to achieve its intended biological effect is reduced appreciably ..
  30. TAS::75 0849::TAS MAGNETICALLY ENERGIZED NANOPARTICLES FOR TREATING OVARIAN CANC
    STEPHEN BARRY; Fiscal Year: 2010
    ..treatment of other metastatic diseases, nanoparticle uptake after intravenous injection by cells of the reticuloendothelial system limits tumor exposure and is an impediment to delivery of systemically administered nanoparticles...
  31. Synergistic chemo-siRNA combination therapy
    M Guillaume Wientjes; Fiscal Year: 2013
    ..to their unfavorable physicochemical properties, instability and rapid elimination or entrapment in the reticuloendothelial system (RES), lysosomal degradation, and toxicity...
  32. Contrast-Enhanced Ultrasound Detection of Secondary Lymph Nodes
    Barry B Goldberg; Fiscal Year: 2010
    ..thirty melanoma-bearing swine will be studied. A reticuloendothelial system-specific ultrasound contrast agent (UCA) will be injected around each melanoma followed by CEUS to ..
  33. STRUCTURE-FUNCTION STUDIES OF HUMAN PLASMA FIBRONECTIN
    Robert Smith; Fiscal Year: 1990
    ..of important biological processes including cell adhesion, connective tissue formation, organogenesis, reticuloendothelial system function, malignancy and metastasis, hemostasis and wound healing...
  34. CLUSTERIN AND RENAL INJURY
    Mark Rosenberg; Fiscal Year: 2004
    ..the uptake and degradation of immune complexes by Kupffer and endothelial cells, components of the liver reticuloendothelial system, will then be tested...
  35. Fluorescence-based screen to probe hepcidin-ferroportin interactions
    Marianne Wessling Resnick; Fiscal Year: 2006
    ..Macrophages of the reticuloendothelial system also play a major role in iron metabolism by recycling iron from damaged or senescent erythrocytes...
  36. CANDIDIASIS--IMMUNO-INHIBITION BY MANNAN CATABOLITES
    Robert Nelson; Fiscal Year: 1992
    ..from growing and phagocytized organisms is catabolized by local macrophages and fixed macrophages of the reticuloendothelial system. Mannan in its native form is an effective antigen for stimulation of T- lymphocyte proliferation, but ..
  37. Candida-endothelial interactions under conditions of flow
    Martin Thornhill; Fiscal Year: 2007
    ..into the tissues, prevent the resulting tissue damage and increase the exposure of circulating organisms to anti-fungal agents and the reticuloendothelial system so that they can be destroyed. [unreadable] [unreadable] [unreadable]
  38. Sulfhydryl Cross-linked Targeted Gene Delivery
    KEVIN RICE; Fiscal Year: 2006
    ..the surface of DNA condensates that blocks protein binding and masks DNA condensate recognition by the reticuloendothelial system. Targeting specificity will be achieved by derivatizing a cross-linking peptide with a single N-glycan ..
  39. Multifunctional low-density lipoprotein nanoplatforms
    Gang Zheng; Fiscal Year: 2005
    ..Being endogenous carriers, lipoproteins are not immunogenic and escape recognition by the reticuloendothelial system. This project will initiate a broad exploration of lipoprotein particles as diverse and biocompatible ..
  40. Nanocarrier-based CT constrast agents for cardiac imaging
    CHANDRA VIJAYALAKSHMI; Fiscal Year: 2005
    ..with a half-life of 8-24 hours, and, (2) clear from the circulation via the liver and the rest of the reticuloendothelial system. Contents of the liposomes will therefore only minimally contact the renal system...
  41. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2009
    ..Expression of zinc transporter genes of the reticuloendothelial system during the acute phase response will be evaluated...
  42. Therapeutic Targeting of the Infectious Path of Anthrax
    ANTHONY SCOTTO; Fiscal Year: 2003
    Anthrax is often misrepresented as an intracellular disease of the macrophages/reticuloendothelial system (RES)...
  43. SALMOLYSIN MEDIATED VIRULENCE IN SALMONELLA
    STEPHEN LIBBY; Fiscal Year: 1999
    ..involved in the characteristic ability of Salmonella to survive and replicate within the cells of the reticuloendothelial system. In this proposal, the survival and replication of a sly mutant of Salmonella typhimurium will be ..
  44. NEW STRATEGIES FOR IMMUNOTOXIN THERAPY
    Ellen Vitetta; Fiscal Year: 1993
    ..clearance, biodistribution, homing to target cells, damage to normal tissue and uptake by cells of the reticuloendothelial system. In addition, we will use the "piggyback" approach of cell-reactive A-IT and anti-antibody linked to ..
  45. ELECTRON MICROSCOPY OF THE RETICULOENDOTHELIAL SYSTEM
    LEON WEISS; Fiscal Year: 1991
    ..Work is in progress on the spleen in sickle cell disease and the thalassemias, correlating findings with those in animal models...
  46. Evaluation of vectors based on group B adenoviruses
    Andre Lieber; Fiscal Year: 2009
    ..CAR), and innate toxicity induced upon intravascular application (in part due to uptake by cells of the reticuloendothelial system, particularly Kupffer cells)...
  47. Role of Haptoglobin in Development Language Disorders
    SAYED SADRZADEH; Fiscal Year: 2004
    ..Haptoglobin (Hp) is a plasma protein which binds free Hb and speeds its removal through the reticuloendothelial system. Thus, we propose the defective removal of free Hb from the CNS, coupled with ensuing Hb-mediated CNS ..
  48. JCV Virus Expression in Oropharynx and HIV
    Joseph Berger; Fiscal Year: 2004
    ..JCV remains latent in the reticuloendothelial system following the initial infection...
  49. ALLOIMMUNIZATION TO PATERNAL LEUKOCYTES FOR HDN
    Kenneth Moise; Fiscal Year: 2002
    ..A monocyte monolayer assay will be performed using the spleens and sensitized red cells of the pups from the three serial breedings to determine the level of phagocytosis of the fetal reticuloendothelial system.
  50. OPSONINS IN NEONATAL IMMUNITY TO GROUP B STREPTOCOCCI
    MORVEN EDWARDS; Fiscal Year: 1991
    ..The reticuloendothelial system (RES) clearance of GBS will be characterized using a neonatal guinea pig (GP) model of infection by (1) ..
  51. LIPOSOME TARGETING TO TUMOR CELLS IN VIVO
    Demetrios Papahadjopoulos; Fiscal Year: 1991
    ..e., the endothelial barrier and the uptake by the reticuloendothelial system (RES)...
  52. LIPOSOMAL CONTRAST AGENTS FOR MR IMAGING
    Evan Unger; Fiscal Year: 1991
    ..To overcome this problem, liposomal iodinated contrast media, which target to the reticuloendothelial system have also been used for CT and have resulted in improved detection of malignancy, However, a limitation ..
  53. STEALTH LIPOSOME ENCAPSULATED HEMOGLOBIN--LOW TOXICITY
    PAUL USTER; Fiscal Year: 1992
    ..host defense by saturating the capacity of the mononuclear phagocyte system (also referred to as the reticuloendothelial system or RES) to clear pathogens from the bloodstream. "Stealth" liposomes (i.e...
  54. STRESS AND MYOCARDIAL INJURY: A SYSTEMATIC STUDY
    Dean Miller; Fiscal Year: 1980
    ..in normal control animals, with undamaged vascular endotheliums, platelets are simply destroyed by the reticuloendothelial system, or whether a more complex situation obtains, involving an adherence of some platelets to the "normal" ..
  55. STRUCTURED LIPIDS IN CATABOLIC STATES
    Bruce Bistrian; Fiscal Year: 1993
    ..one novel injury model (burn injury + monokine infusion) and 4) investigate whether the function of the reticuloendothelial system is relatively preserved with parenteral administration...
  56. CIG FUNCTION: INTERACTION WITH FREE MACROPHAGES
    ANDY REESE; Fiscal Year: 1980
    ..or indirectly associated its opsonic activity with the function of the sessile macrophages of the reticuloendothelial system (RES), particularly to the Kupffer cells of liver...
  57. Development of Carbon Nanoencapsulates for Biomedicine
    ROBERT BOLSKAR; Fiscal Year: 2001
    ..use in MRI laboratories and hospitals around the country in applications like MR angiography, imaging of reticuloendothelial system components, imaging of cancerous lesions with targeted agents, and for imaging gene expression and other ..
  58. COMPREHENSIVE SICKLE CELL CENTER
    Cage Johnson; Fiscal Year: 2002
    ..of the sickle RBC whole two other projects explore those characteristics of the vascular endothelium and reticuloendothelial system which contribute to vaso-occlusion...
  59. PROTOTYPES OF ARTIFICIAL RED BLOOD CELLS
    C Hunt; Fiscal Year: 1990
    ..Just as normal RBC's circulate undetected, and then age and are cleared by the reticuloendothelial system, artificial RBC's should initially be some what invisible to the RES, and as they age become ..
  60. Developing a CEST Reporter Gene (RMI)
    JEFF BULTE; Fiscal Year: 2008
    ..To achieve this goal, our aim is to synthesize novel, more efficient CEST reporter genes, and to detect double-labeled LRP/ARP transfected glioma cells and neural stem cells individually in live animals. [unreadable] [unreadable]..