lymphatic system

Summary

Summary: A system of organs and tissues that process and transport immune cells and LYMPH.

Top Publications

  1. ncbi Structure and function of the lymphatic system: an overview
    Sandy Ellis
    St George s Hospital, London
    Br J Community Nurs 11:S4-6. 2006
  2. pmc LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
    S Banerji
    University of Oxford, Molecular Immunology Group, Nuffield Department of Medicine, John Radcliff Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Cell Biol 144:789-801. 1999
  3. ncbi Lymphatic metastasis in the absence of functional intratumor lymphatics
    Timothy P Padera
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Science 296:1883-6. 2002
  4. ncbi Molecular mechanisms of lymphangiogenesis in health and disease
    Kari Alitalo
    Molecular Cancer Biology Laboratory, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Cancer Cell 1:219-27. 2002
  5. ncbi Focus on lymphangiogenesis in tumor metastasis
    Marc G Achen
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Cancer Cell 7:121-7. 2005
  6. doi VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium
    Tara Karnezis
    Tumour Angiogenesis Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Cancer Cell 21:181-95. 2012
  7. ncbi Intestinal lymphatic drug transport: an update
    C J Porter
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University Parkville Campus, 381 Royal Parade, Parkville, Victoria 3052, Australia
    Adv Drug Deliv Rev 50:61-80. 2001
  8. ncbi The physiology of the lymphatic system
    M A Swartz
    Departments of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Adv Drug Deliv Rev 50:3-20. 2001
  9. ncbi Molecular control of lymphangiogenesis
    Megan E Baldwin
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Bioessays 24:1030-40. 2002
  10. ncbi Lymphatic vessels in cancer metastasis: bridging the gaps
    Ramin Shayan
    Angiogenesis Laboratory, Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    Carcinogenesis 27:1729-38. 2006

Detail Information

Publications254 found, 100 shown here

  1. ncbi Structure and function of the lymphatic system: an overview
    Sandy Ellis
    St George s Hospital, London
    Br J Community Nurs 11:S4-6. 2006
    The lymphatic system is often overlooked, but is a vital part both of the circulation and the immune system...
  2. pmc LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
    S Banerji
    University of Oxford, Molecular Immunology Group, Nuffield Department of Medicine, John Radcliff Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Cell Biol 144:789-801. 1999
    ..Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves...
  3. ncbi Lymphatic metastasis in the absence of functional intratumor lymphatics
    Timothy P Padera
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Science 296:1883-6. 2002
    ..These findings suggest that the functional lymphatics in the tumor margin alone are sufficient for lymphatic metastasis and should be targeted therapeutically...
  4. ncbi Molecular mechanisms of lymphangiogenesis in health and disease
    Kari Alitalo
    Molecular Cancer Biology Laboratory, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Cancer Cell 1:219-27. 2002
    ..In addition, these studies have opened novel diagnostic and therapeutic avenues for the treatment of lymphedema and metastasis. This overview highlights the recent insights and developments in the field of lymphatic vascular research...
  5. ncbi Focus on lymphangiogenesis in tumor metastasis
    Marc G Achen
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Cancer Cell 7:121-7. 2005
  6. doi VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium
    Tara Karnezis
    Tumour Angiogenesis Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Cancer Cell 21:181-95. 2012
    ..Collecting lymphatics therefore play an active and important role in metastasis and may provide a therapeutic target to restrict tumor spread...
  7. ncbi Intestinal lymphatic drug transport: an update
    C J Porter
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University Parkville Campus, 381 Royal Parade, Parkville, Victoria 3052, Australia
    Adv Drug Deliv Rev 50:61-80. 2001
    ..Finally the possible future directions for studies of intestinal lymphatic transport are discussed, including the use of cell culture models and genetically modified animals...
  8. ncbi The physiology of the lymphatic system
    M A Swartz
    Departments of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Adv Drug Deliv Rev 50:3-20. 2001
    This paper presents an overview of the anatomy, physiology, and biology of the lymphatic system specifically relevant to lymphatic drug delivery...
  9. ncbi Molecular control of lymphangiogenesis
    Megan E Baldwin
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Bioessays 24:1030-40. 2002
    ..The capacity to induce lymphangiogenesis by manipulation of the VEGF-C/VEGF-D/VEGFR-3 signaling pathway offers new opportunities to understand the function of the lymphatic system and to develop novel treatments for lymphatic disorders.
  10. ncbi Lymphatic vessels in cancer metastasis: bridging the gaps
    Ramin Shayan
    Angiogenesis Laboratory, Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    Carcinogenesis 27:1729-38. 2006
    ..groups of clinical researchers and basic scientists have been working to unravel the mysteries of the lymphatic system. This review aims to summarize these contributions, in terms of the history, identification, structure and ..
  11. pmc Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis
    Janice A Nagy
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Exp Med 196:1497-506. 2002
    ..These findings raise the possibility that similar, abnormal lymphatics develop in other pathologies in which VEGF-A is overexpressed, e.g., malignant tumors and chronic inflammation...
  12. pmc Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
    T Makinen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, FIN 00014 Helsinki, Finland
    EMBO J 20:4762-73. 2001
    ..The culture of isolated lymphatic endothelial cells should now allow further studies of the molecular properties of these cells...
  13. ncbi The lymphatic system in body homeostasis: physiological conditions
    Waldemar L Olszewski
    Medical Research Center, Polish Academy of Science, Warsaw, Poland
    Lymphat Res Biol 1:11-21; discussion 21-4. 2003
    The lymphatic system is an organized network composed of functionally interrelated lymphoid tissue, and transportation pathways of tissue fluid/lymph and lymphoid cells. Its main components are 1...
  14. ncbi Interstitial flow as a guide for lymphangiogenesis
    Kendrick C Boardman
    Chemical Engineering Department, McCormick School of Engineering and Applied Sciences, Northwestern University, 2145 Sheridan, Evanston, Ill 60208 3107, USA
    Circ Res 92:801-8. 2003
    The lymphatic system is important in tissue fluid balance regulation, immune cell trafficking, edema, and cancer metastasis, yet very little is known about the sequence of events that initiate and coordinate lymphangiogenesis...
  15. ncbi Conjunctival lymphatic system
    Daljit Singh
    J Cataract Refract Surg 29:632-3. 2003
  16. ncbi Scintigraphic investigations of the lymphatic system: the influence of injected volume and quantity of labeled colloidal tracer
    Pierre Bourgeois
    Service of Nuclear Medicine, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    J Nucl Med 48:693-5. 2007
    ..The aim of the present study was to evaluate whether and how volume and quantity quantitatively affect lymphoscintigraphic results...
  17. pmc The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis
    Zhiying Zou
    Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 121:3228-36. 2013
    ..Our findings reveal that CCBE1 plays an essential role in regulating the fetal liver erythropoietic environment and suggest that EBI formation is regulated differently in the fetal liver and bone marrow...
  18. pmc Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma
    M Skobe
    Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Pathol 159:893-903. 2001
    ..Taken together, our results identify VEGF-C as multifunctional factor involved in regulating tumor lymphangiogenesis, angiogenesis, and immune response...
  19. ncbi New insights into the biology and pathology of the cutaneous lymphatic system
    Satoshi Hirakawa
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Dermatol Sci 35:1-8. 2004
    The cutaneous lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, in the afferent phase of the immune response, and in the metastatic spread of skin cancers...
  20. doi Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80
    Marianne L Lind
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    Eur J Pharm Sci 35:211-8. 2008
    ..The fraction of halofantrine transported to the lymphatic system was determined as the difference between the bioavailability in saline-pretreated rats and cycloheximide-..
  21. ncbi Evaluation of a chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophilic drugs
    Arik Dahan
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P O Box 12065, Jerusalem 91120, Israel
    Eur J Pharm Sci 24:381-8. 2005
    ..In conclusion, the chemical blockage of chylomicron flow provides a potential approach for lymphatic transport investigation, and may elucidate processes involving in the absorption of lipophilic compounds...
  22. ncbi Anatomy and physiology of lymphatic drainage of the breast from the perspective of sentinel node biopsy
    P J Tanis
    Department of Surgery, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam
    J Am Coll Surg 192:399-409. 2001
    Knowledge of the anatomy and physiology of the lymphatic system is helpful when considering a particular sentinel node biopsy technique...
  23. ncbi Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated microvessels in man and animals
    Dian Feng
    Department of Pathology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Microsc Res Tech 57:289-326. 2002
    ....
  24. ncbi Prox1 function is required for the development of the murine lymphatic system
    J T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell 98:769-78. 1999
    The lack of specific markers has raised problems in documenting the precise manner by which the lymphatic system develops...
  25. pmc Low doses of hepadnavirus induce infection of the lymphatic system that does not engage the liver
    Tomasz I Michalak
    Molecular Virology and Hepatology Research, Division of Basic Medical Sciences, Faculty of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland A1B 3V6, Canada
    J Virol 78:1730-8. 2004
    ..related to human hepatitis B virus and is considered to be principally hepatotropic, invades the host's lymphatic system and persists in lymphoid cells independently of whether the infection is symptomatic and serologically ..
  26. doi Lymphatic system: a prospective area for advanced targeting of particulate drug carriers
    Indu Singh
    National Institute of Pharmaceutical Education and Research NIPER, Department of Pharmaceutics, Hyderabad 500037, India 91 40 27193004, 91 40 23073741 91 40 27193753, 91 40 23073751
    Expert Opin Drug Deliv 11:211-29. 2014
    The lymphatic system has a critical role in the immune system's recognition and response to disease and it is an additional circulatory system throughout the entire body...
  27. ncbi Pathways of lymphatic drainage from the breast
    S D Nathanson
    Department of Surgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    Ann Surg Oncol 8:837-43. 2001
    ..We hypothesized that common lymphatic trunks drain both a large volume of breast parenchyma and skin and that intradermal or intraparenchymal routes flow to the same axillary node...
  28. pmc Advanced drug delivery to the lymphatic system: lipid-based nanoformulations
    Arshad Ali Khan
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia
    Int J Nanomedicine 8:2733-44. 2013
    The delivery of drugs and bioactive compounds via the lymphatic system is complex and dependent on the physiological uniqueness of the system...
  29. doi Examination of lymphatic transport of puerarin in unconscious lymph duct-cannulated rats after administration in microemulsion drug delivery systems
    Hongfei Wu
    Department of Pharmaceutics, Anhui University of Traditional Chinese Medicine, Anhui Province, China
    Eur J Pharm Sci 42:348-53. 2011
    ..The results imply that the pharmaceutical scientist may use microemulsion formulations to optimize lymph-targeting drug delivery systems, by improving the extent of lymphatic transport...
  30. ncbi Nonenhanced magnetic resonance lymphoductography: visualization of lymphatic system of the trunk on 3-dimensional heavily T2-weighted image with 2-dimensional prospective acquisition and correction
    Satoshi Matsushima
    Department of Radiology, The Jikei University School of Medicine, Tokyo, Japan
    J Comput Assist Tomogr 31:299-302. 2007
    ..T2-weighted images obtained with 2-dimensional prospective acquisition and correction in visualization of the lymphatic system of the trunk...
  31. doi The cardiac lymphatic system
    Marios Loukas
    Department of Anatomical Sciences, School of Medicine, St George s University, Grenada, West Indies
    Clin Anat 24:684-91. 2011
    The lymphatic system, a network of vessels carrying clear interstitial fluid called lymph, is found throughout the human body...
  32. ncbi Imaging the lymphatic system: possibilities and clinical applications
    Olivier Clement
    Service de Radiologie, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75908 Paris Cedex 15, France
    Eur Radiol 14:1498-507. 2004
    The lymphatic system is anatomically complex and difficult to image. Lymph ducts are responsible for the drainage of part of the body's interstitial fluid...
  33. ncbi Autopsy case of congenital pulmonary lymphangiectasis
    Hiroshi Hirano
    Second Department of Pathology, Hyogo College of Medicine, Hyogo, Japan
    Pathol Int 54:532-6. 2004
    ..The clinical behavior and prognosis of CPL depend on the extent of pulmonary involvement of the lymphatic dilatations regardless of systemic lymphatic dilations...
  34. pmc T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 22:3546-56. 2003
    ..These data identify T1alpha/podoplanin as a novel critical player that regulates different key aspects of lymphatic vasculature formation...
  35. ncbi Abnormal lymphatic vessel development in neuropilin 2 mutant mice
    Li Yuan
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75005 Paris, France
    Development 129:4797-806. 2002
    ..Arteries, veins and larger, collecting lymphatic vessels developed normally, suggesting that neuropilin 2 is selectively required for the formation of small lymphatic vessels and capillaries...
  36. pmc Microangiopathy of cutaneous blood and lymphatic capillaries in chronic venous insufficiency (CVI)
    U K Franzeck
    Department of Internal Medicine, University Hospital, , Switzerland
    Yale J Biol Med 66:37-46. 1993
    ..These findings demonstrate a special lymphatic microangiopathy in CVI, suggesting an additional lymphatic component in the edema formation...
  37. doi Assessment of the lymphatic system in patients with diffuse lymphangiomatosis by magnetic resonance imaging
    Christian Lohrmann
    Department of Radiology, University Hospital of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg i Br, Germany
    Eur J Radiol 80:576-81. 2011
    To assess the lymphatic system in patients with diffuse lymphangiomatosis by magnetic resonance imaging.
  38. doi Chronic lower extremity lymphedema: a comparative study of high-resolution interstitial MR lymphangiography and heavily T2-weighted MRI
    Qing Lu
    Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dong Fang Rd, Shanghai 200127, China
    Eur J Radiol 73:365-73. 2010
    ..To assess the role of heavily T2-weighted image and interstitial MR lymphangiography (MRL) for the visualization of lymphatic vessels in patients with disorders of the lymphatic circulation...
  39. doi Role of the lymphatic system in the pathogenesis of Crohn's disease
    Pierre Yves von der Weid
    Inflammation Research Network and Smooth Muscle Research Group, Snyder Institute of Infection, Immunity and Inflammation, Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Curr Opin Gastroenterol 27:335-41. 2011
    ..The lymphatic system is re-emerging as a critical player in inflammatory and immune processes and the purpose of this review is to ..
  40. ncbi Tumor lymphangiogenesis in inflammatory breast carcinoma: a histomorphometric study
    Ilse Van der Auwera
    Translational Cancer Research Group Antwerp, Laboratory of Pathology, University of Antwerp University Hospital Antwerp, Edegem, Belgium
    Clin Cancer Res 11:7637-42. 2005
    At the time of diagnosis, metastatic dissemination of tumor cells via the lymphatic system has occurred in nearly all patients with inflammatory breast cancer (IBC)...
  41. ncbi Manual techniques addressing the lymphatic system: origins and development
    Bruno J Chikly
    Medical Faculty of Paris
    J Am Osteopath Assoc 105:457-64. 2005
  42. ncbi Lymphatic system as a path underlying the spread of lung and gut injury after intestinal ischemia/reperfusion in rats
    Gabriela Cavriani
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brasil
    Shock 23:330-6. 2005
    We investigated in rats the influence of the lymphatic system and of tumor necrosis factor (TNF) on the lung inflammation resulting from intestinal ischemia/reperfusion (I/R) performed by 45-min occlusion of the superior mesenteric artery ..
  43. ncbi A model and reference data for retrospective dose assessment of organ doses (red bone marrow, lymphatic system) in diagnostic radiography and nuclear medicine, 1946-1995
    H von Boetticher
    Institute for Radiology, Klinikum Links der Weser, Bremen, Germany
    Health Phys 92:315-31. 2007
    ..The model and the results can be readily extended to different countries with different technical advancement and standard of radiologic practice...
  44. ncbi Arnold Heller and the lymph pump
    K Aukland
    Institute for Biomedicin, Physiology Section, University of Bergen, Bergen, Norway
    Acta Physiol Scand 185:171-80. 2005
    ..Recently it has been shown that passive lymph flow may add to active propulsion. Both mechanisms depend on lymph formation, i.e. the uptake of interstitial fluid by the initial lymph vessels which is still not well understood...
  45. pmc Lymphatic system: a vital link between metabolic syndrome and inflammation
    Sanjukta Chakraborty
    Division of Lymphatic Biology, Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Texas A and M Health Science Center College of Medicine, College Station, Texas 77843, USA
    Ann N Y Acad Sci 1207:E94-102. 2010
    ..However, despite the overlap of metabolic syndrome pathology with lymphatic function, tangent effects on the lymphatic system have not been extensively documented...
  46. pmc The new era of the lymphatic system: no longer secondary to the blood vascular system
    Inho Choi
    Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cold Spring Harb Perspect Med 2:a006445. 2012
    ..Although the blood system has been studied extensively, the lymphatic system has received much less scientific and medical attention because of its elusive morphology and mysterious ..
  47. ncbi The pathomechanism of posttraumatic edema of the lower limbs: II--Changes in the lymphatic system
    Grzegorz Szczesny
    Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    J Trauma 55:350-4. 2003
    The peripheral lymphatic system reacts to penetrating microorganisms and self-antigens released from tissues and cells damaged by trauma or intracellular pathogens...
  48. ncbi Use of an artificial lymphatic system during carboplatin infusion to improve canine osteosarcoma blood flow and clinical response
    Gene R DiResta
    Orthopaedic Surgical Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021 6007, USA
    Ann Surg Oncol 14:2411-21. 2007
    The artificial lymphatic system (ALS), a mechanical system designed to reduce increased interstitial fluid pressure in solid tumors and enhance the delivery of chemotherapy, was evaluated within a randomized clinical trial treating ..
  49. doi Superficial lymphatic system of the upper torso: preliminary radiographic results in human cadavers
    Hiroo Suami
    Jack Brockhoff Reconstructive Plastic Surgery Research Unit, Royal Melbourne Hospital, Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia
    Plast Reconstr Surg 121:1231-9. 2008
    ..Despite increasing clinical information, the basic anatomy of the superficial lymphatic system of the upper torso has not been fully elucidated.
  50. doi Molecular regulation of lymphatic contractility
    Mariappan Muthuchamy
    Department of Systems Biology and Translational Medicine, College of Medicine, Cardiovascular Research Institute Division of Lymphatic Biology, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Ann N Y Acad Sci 1131:89-99. 2008
    The lymphatic system plays critical roles in body fluid and macromolecular homeostasis, lipid absorption, immune function, and metastasis...
  51. ncbi Growth factors controlling angiogenesis and lymphangiogenesis
    Kari Alitalo
    Ugeskr Laeger 164:3170-2. 2002
  52. pmc Modelling the lymphatic system: challenges and opportunities
    K N Margaris
    Department of Bioengineering, University of Strathclyde, 106 Rottenrow, Glasgow G4 0NW, UK
    J R Soc Interface 9:601-12. 2012
    The lymphatic system is a vital part of the circulatory and immune systems, and plays an important role in homeostasis by controlling extracellular fluid volume and in combating infection...
  53. pmc Determinants of valve gating in collecting lymphatic vessels from rat mesentery
    Michael J Davis
    Dept of Medical Pharmacology and Physiology, Univ of Missouri School of Medicine, 1 Hospital Dr, Rm M451, Columbia, MO 65212, USA
    Am J Physiol Heart Circ Physiol 301:H48-60. 2011
    ..Similarly, the pressure gradient required for valve opening varied sixfold with vessel distention. Finally, our functional evidence supports the concept that lymphatic muscle tone exerts an indirect effect on valve gating...
  54. doi [Lymphatic system: Anatomy, histology and physiology]
    Isabelle Quere
    CHU Saint Eloi, Universite de Montpellier I, centre de compétence maladies lymphatiques constitutionnelles, Service de Medecine Vasculaire, 34295 Montpellier Cedex 5, France
    Presse Med 39:1269-78. 2010
    Our knowledge of the anatomy of the lymphatic system may have changed little, if at all, since the first descriptions of this system in the 17th and 18th centuries, but the identification of specific markers of lymphatic endothelial cells ..
  55. doi The role of the lymphatic system in vaccine trafficking and immune response
    Ivy Pal
    School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA
    Adv Drug Deliv Rev 63:909-22. 2011
    ..A thorough understanding of the lymphatic system is essential considering the role it plays in antigen trafficking and all immunological activity...
  56. pmc Existence of the lymphatic system in the primate corpus luteum
    Fuhua Xu
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Lymphat Res Biol 7:159-68. 2009
    To date, there have been no detailed studies on the lymphatic system in the primate corpus luteum (CL); early reports suggested that the presence of this "secondary circulation" in luteal tissue is species-dependant...
  57. ncbi Intrinsic pump-conduit behavior of lymphangions
    Christopher M Quick
    College of Veterinary Medicine, 4466 Texas A and M University, College Station, TX 77843 4466, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1510-8. 2007
    ..This analysis may explain a possible physiological benefit of the observed flow-mediated inhibition of the lymphatic pump at high flow rates...
  58. ncbi Physiology of human lymphatic contractility: a historical perspective
    A A Gashev
    Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, College Station 77843-1114, USA
    Lymphology 34:124-34. 2001
    The lymphatic system is a transport system that has important roles in fluid/macromolecule homeostasis, lipid absorption, metastasis and immune function...
  59. ncbi "Artificial lymphatic system": a new approach to reduce interstitial hypertension and increase blood flow, pH and pO2 in solid tumors
    G R DiResta
    Memorial Sloan Kettering Cancer Center s Department of Surgery Orthopaedic Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Biomed Eng 28:543-55. 2000
    A mechanical drainage system, the "artificial lymphatic system" (ALS), consisting of a vacuum source and drain, is evaluated for its ability to aspirate the interstitial fluids responsible for the elevated interstitial fluid pressure (IFP)..
  60. ncbi Pancreatic lymphatic system in rodents
    M Regoli
    Department of Biomedical Sciences, University of Siena, I-53100 Siena, Italy
    Anat Rec 263:155-60. 2001
    ..This research is aimed to supply the morphologic basis to outline the involvement of the lymphatic system in pancreatic pathology...
  61. pmc Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells
    Satoshi Hirakawa
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Am J Pathol 162:575-86. 2003
    ....
  62. ncbi Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate
    Young Kwon Hong
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Dev Dyn 225:351-7. 2002
    ....
  63. ncbi Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2
    Bradley K McColl
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
    FASEB J 21:1088-98. 2007
    ..The finding that PCs promote activation of VEGF-D and other proteins with roles in cancer such as matrix metalloproteinases, emphasizes the importance of these enzymes as potential regulators of tumor progression and metastasis...
  64. ncbi Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours
    M Fukunaga
    Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan
    Histopathology 46:396-402. 2005
    ..D2-40 is a novel monoclonal antibody to a Mr 40 000 O-linked sialoglycoprotein that reacts with a fixation-resistant epitope in lymphatic endothelium...
  65. ncbi Molecular lymphangiogenesis: new players
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Helsinki University Central Hospital, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Helsinki, Finland
    Trends Cell Biol 15:434-41. 2005
    ..This review provides an overview of the molecular players involved in lymphangiogenesis, with special emphasis on recently discovered molecular mechanisms...
  66. doi Effect of poloxamer 188 on lymphatic uptake of carvedilol-loaded solid lipid nanoparticles for bioavailability enhancement
    Baboota Sanjula
    Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi, India
    J Drug Target 17:249-56. 2009
    ..05) than that of carvedilol suspension (1.27 +/- 0.23 microgh/mL). These findings augur well with the possibility of enhancement of the oral bioavailability of drug, via the lymphatic system bypassing hepatic first pass metabolism.
  67. ncbi PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
    Renhai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    Cancer Cell 6:333-45. 2004
    Cancer metastases are commonly found in the lymphatic system. Like tumor blood angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several tumor-derived growth factors...
  68. ncbi Functional interaction of VEGF-C and VEGF-D with neuropilin receptors
    Terhi Karpanen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, P O B 63, FI 00014 University of Helsinki, Helsinki, Finland
    FASEB J 20:1462-72. 2006
    ..Our results show that NP2 is directly involved in an active signaling complex with the key regulators of lymphangiogenesis and thus suggest a mechanism by which NP2 functions in the development of the lymphatic vasculature...
  69. pmc Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D
    Bradley K McColl
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    J Exp Med 198:863-8. 2003
    ..Identification of an enzyme that activates the lymphangiogenic growth factors will facilitate development of inhibitors of metastasis...
  70. pmc Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Am J Pathol 166:913-21. 2005
    ....
  71. ncbi Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides
    Rene Holm
    Department of Pharmaceutics, The Royal Danish School of Pharmacy, Universitetsparken 2, 2100, Copenhagen, Denmark
    Eur J Pharm Sci 20:91-7. 2003
    ..This could indicate the utility of disperse lipid-base formulations based on structured triglycerides for the oral delivery of halofantrine, and potentially other lipophilic drugs...
  72. ncbi Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
    T Karpanen
    Molecular/Cancer Biology Laboratory, Haartman Institute and Ludwig Institute for Cancer Research, University of Helsinki, Finland
    Cancer Res 61:1786-90. 2001
    ..Our data suggest that VEGF-C facilitates tumor metastasis via the lymphatic vessels and that tumor spread can be inhibited by blocking the interaction between VEGF-C and its receptor...
  73. doi Animal models for the molecular and mechanistic study of lymphatic biology and disease
    William S Shin
    Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Ann N Y Acad Sci 1131:50-74. 2008
    The development of animal model systems for the study of the lymphatic system has resulted in an explosion of information regarding the mechanisms governing lymphatic development and the diseases associated with lymphatic dysfunction...
  74. ncbi LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis
    C Mouta Carreira
    Steele Laboratory for Tumor Biology, Department of Radiation Oncology Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Res 61:8079-84. 2001
    ..Finally, the presence of LYVE-1 in liver sinusoidal endothelia suggests that LYVE-1 has functions beyond the lymph vascular system...
  75. pmc Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages
    E Kriehuber
    Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, University of Vienna Medical School, Austria
    J Exp Med 194:797-808. 2001
    ..These results demonstrate that LECs and BECs constitute stable and specialized EC lineages equipped with the potential to navigate leukocytes and, perhaps also, tumor cells into and out of the tissues...
  76. ncbi Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812 8581, Japan
    J Nutr 135:155-9. 2005
    ..Because postprandial hypertriacylglycerolemia is a risk factor for coronary heart disease, our results suggest that catechins with a galloyl moiety may prevent this disease...
  77. ncbi Animal models for the study of lymphatic insufficiency
    William S Shin
    Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Lymphat Res Biol 1:159-69. 2003
    ..Such models will help to refine the assessment of various therapeutic approaches and their potential applicability to human disease interventions...
  78. ncbi Role of the gut lymphatic system in multiple organ failure
    E A Deitch
    Department of Surgery, New Jersey Medical School, Room G 506, 185 South Orange Avenue, Newark, NJ 07103, USA
    Curr Opin Crit Care 7:92-8. 2001
    ..Finally, it would help explain the discordant results between experimental and some clinical studies on the role of gut injury and loss of gut barrier function in the development of a systemic inflammatory state and distant organ injury...
  79. doi MR imaging of the lymphatic system in patients with lipedema and lipo-lymphedema
    Christian Lohrmann
    Department of Radiology, University Hospital of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg i Br, Germany
    Microvasc Res 77:335-9. 2009
    To assess for the first time the morphology of the lymphatic system in patients with lipedema and lipo-lymphedema of the lower extremities by MR lymphangiography.
  80. ncbi Lymphangiogenesis and lymphangiodysplasia: from molecular to clinical lymphology
    M H Witte
    Department of Surgery, The University of Arizona College of Medicine, Tucson, Arizona 85724 5063, USA
    Microsc Res Tech 55:122-45. 2001
    ....
  81. pmc Role of the lymphoreticular system in prion neuroinvasion from the oral and nasal mucosa
    Richard A Bessen
    Department of Veterinary Molecular Biology, P O Box 173610, Montana State University, Bozeman, MT 59717, USA
    J Virol 83:6435-45. 2009
    ....
  82. ncbi The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature
    Guillermo Oliver
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 16:773-83. 2002
  83. ncbi Vascular growth factors and lymphangiogenesis
    Lotta Jussila
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Finland
    Physiol Rev 82:673-700. 2002
    ..vessels were discovered already 300 years ago, at the same time as the blood circulation was described, the lymphatic system has remained relatively neglected until recently...
  84. pmc Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea
    Hajime Kubo
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, POB 63, Haartmaninkatu 8, 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 99:8868-73. 2002
    ..Because increased expression of FGF-2 and VEGF-C has been associated with lymphatic metastasis, our results provide a potential strategy for the inhibition of lymphatic metastasis in cancer therapy...
  85. pmc Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
    S J Mandriota
    Department of Morphology, University Medical Centre, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    EMBO J 20:672-82. 2001
    ..These mice frequently developed pancreatic lymph node metastases. Our findings demonstrate that VEGF-C-induced lymphangiogenesis mediates tumour cell dissemination and the formation of lymph node metastases...
  86. ncbi Molecular targeting of liposomal nano-particles to lymphatic system
    Nguyen Van Cuong
    Department of Biomedical Engineering, Chung Yuan Christian University, 200 Chung Pei Rd, Chung Li, Taiwan 32023, R O China
    Curr Cancer Drug Targets 11:147-55. 2011
    ..The lymphatic system is an important highway to spread the metastasis of most human cancers including breast, colon, and lung, ..
  87. pmc Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic duct
    Anatoliy A Gashev
    Department of Medical Physiology, Cardiovascular Research Institute, College of Medicine, Texas A and M University System Health Science Center, 336 Reynolds Medical Building, College Station, TX 77843 1114, USA
    J Physiol 540:1023-37. 2002
    ..Exposure to NO mimicked the effects of flow, and inhibition of the NO synthase by N (G)-monomethyl-L-arginine attenuated but did not completely abolish the effects of flow...
  88. ncbi Cannulation of the cardiac lymphatic system in swine
    J F Vazquez-Jimenez
    Thoracic Cardiovascular Surgery, Universitätsklinikum RWTH Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
    Eur J Cardiothorac Surg 18:228-32. 2000
    ..The purpose of this study was to investigate the cardiac lymphatic anatomy of the swine and to develop a reliable cannulation technique to collect the lymph...
  89. pmc Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk
    Farhad Abtahian
    Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 299:247-51. 2003
    ..These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals...
  90. ncbi Lymphatic function, lymphangiogenesis, and cancer metastasis
    M A Swartz
    Department of Biomedical and Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Microsc Res Tech 55:92-9. 2001
    The lymphatic system serves as the primary route for the metastasis of many cancers and the extent of lymph node involvement is the most important indicator of tumor aggressiveness...
  91. ncbi Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion
    M Glatzel
    Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091, Zurich, Switzerland
    Neuron 31:25-34. 2001
    ..We conclude that sympathetic innervation of lymphoid organs is rate limiting for prion neuroinvasion and that splenic sympathetic nerves may act as extracerebral prion reservoirs...
  92. ncbi Lymphatic system: unlocking the drains
    Phyllida Brown
    Nature 436:456-8. 2005
  93. ncbi Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer
    Cory S M Williams
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    J Pathol 200:195-206. 2003
    ....
  94. ncbi Evidence for a second valve system in lymphatics: endothelial microvalves
    J Trzewik
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, California 92093-0412, USA
    FASEB J 15:1711-7. 2001
    ..In conjunction with the classical (secondary) intralymphatic valves, the primary valves provide the mechanism that facilitates the unidirectional flow during periodic compression and expansion of initial lymphatics...
  95. ncbi Lymphangiogenesis in malignant tumours: Does it occur?
    R Clarijs
    Department of Pathology, University Medical Centre, Nijmegen, The Netherlands
    J Pathol 193:143-6. 2001
    ..been unclear, but since these particular tumour types are also known for their propensity to spread via the lymphatic system, it may be speculated that the presence of a pre-existing lymphatic bed and the formation of new lymphatics (..
  96. doi Lymphangioleiomyomatosis: a disease involving the lymphatic system
    Kuniaki Seyama
    Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Lymphat Res Biol 8:21-31. 2010
    ..The identification of LCCs in chylous effusion together with the characteristic clinical manifestations can therefore be an alternative for a lung biopsy if LAM patients are complicated with chylous effusion...
  97. doi Effects of autotransplanted lymph node fragments on the lymphatic system in the pig model
    K S Blum
    Institute of Diagnostic and Interventional Neuroradiology, OE 8210, Medical School of Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Breast Cancer Res Treat 120:59-66. 2010
    ..so far, therefore we wanted to show the reintegration of transplanted avascular lymph node fragments in the lymphatic system and positive effects of the transplanted fragments on the restoration of the lymphatic flow in this study...
  98. doi Review article: lymphatic system and associated adipose tissue in the development of inflammatory bowel disease
    P Y von der Weid
    Snyder Institute of Infection, Immunity and Inflammation, Department of Physiology and Pharmacology, University of Calgary, AB, Canada
    Aliment Pharmacol Ther 32:697-711. 2010
    The lymphatic system plays critical roles in tissue fluid homoeostasis, immune defence and metabolic maintenance...
  99. pmc Drug delivery to the lymphatic system: importance in future cancer diagnosis and therapies
    Yumei Xie
    University of Kansas, Department of Pharmaceutical Chemistry, Lawrence, KS 66047, USA
    Expert Opin Drug Deliv 6:785-92. 2009
    ..This combination has the potential to both reduce nonspecific organ toxicities and increase the chemotherapeutic dose to the most likely sites of locoregional cancer metastasis...
  100. ncbi Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes
    Anne Saaristo
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum, University of Helsinki and Helsinki University Central Hospital, 00014 Helsinki, Finland
    FASEB J 16:1041-9. 2002
    ..These results show that virally produced VEGF-C induces blood vessel changes, including vascular leak, but its angiogenic potency is much reduced compared with VEGF in normal skin...
  101. pmc The lymphatic system in health and disease
    Leah N Cueni
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Lymphat Res Biol 6:109-22. 2008
    ..There is growing evidence that the lymphatic system also contributes to a number of diseases, such as lymphedema, cancer metastasis and different inflammatory ..

Research Grants66

  1. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..Moreover, the brain lacks a lymphatic system, and is considered an immunologically privileged organ, relying on the blood-brain barrier (BBS) to exclude ..
  2. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    ..The lymphatic system participates centrally in returning HDL to the bloodstream via the thoracic duct, and it also absorbs ..
  3. The lymph node microenvionment in tumor metastasis
    Judith A Varner; Fiscal Year: 2012
    ..lymph nodes even in the absence of a primary tumor when tumor cells were injected directly into the lymphatic system. This homing could be blocked by suppressing lymphangiogenesis with antagonists of integrin ?4?1 or VEGF-R3...
  4. Molecular Basis of Nuchal Edema
    Young Kwon Hong; Fiscal Year: 2013
    ..Although NE has been reported to be associated with disturbed development of the lymphatic system, the molecular basis of NE is currently unknown...
  5. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..cancer LE, a syndrome of abnormal swelling and multiple distressing symptoms, is caused by injuries to the lymphatic system from cancer treatment...
  6. Fluorescein for Sentinel Lymph Node Detection
    James M McGreevy; Fiscal Year: 2012
    ..an operation for breast cancer, malignant melanoma, and other types of cancer that metastasize by way of the lymphatic system. The direct fluorescent visualization technology being developed by Vestan Medical Imaging, Inc...
  7. Role of mesenteric lymphatics and dietary endotoxin in metabolic syndrome
    DAVID CARL ZAWIEJA; Fiscal Year: 2013
    ..high-fat diet-induced MetSyn rat models and a LPS-induced inflammation model to determine the roles of the lymphatic system in the pathophysiology of MetSyn...
  8. The role of lymphatic contraction in inflammation and cancer metastasis
    Shan Liao; Fiscal Year: 2013
    ..cause of lymphedema world-wide is lymphatic filariasis caused by mosquito-borne parasitic infections of the lymphatic system. Globally, it is estimated that there are 120 million filiarial infections, with over 1...
  9. Mechanisms of the Age-related Alterations in Lymphatic Pumping
    Anatoliy A Gashev; Fiscal Year: 2012
    The major task of the lymphatic system is lymph transport. This system of vessels and nodes is designed to transport fluid, soluble molecules and cells from the interstitium through the lymph nodes to the central veins...
  10. Regulation of Pancreatic Tumor Progression by Disabled-2
    Barbara A Hocevar; Fiscal Year: 2010
    ..Part of this is due to the rapid metastasis of pancreatic cancer to the lymphatic system, as well as other organs such as the liver and lungs...
  11. Mechanisms of rapid paravascular fluid transport in the brain
    Jeffrey J Iliff; Fiscal Year: 2012
    ..The brain does not have a conventional lymphatic system, so metabolic waste is cleared from brain extracellular fluid by its transport along the basal lamina, a ..
  12. Color-Coded Imaging of Pancreatic Cancer Microenvironment for Drug Discovery
    Meng Yang; Fiscal Year: 2013
    ..Cells delivered to the lymphatic system are recorded on video in real-time leaving the inguinal lymph node and entering the axillary lymph node...
  13. Role of TNFa in Osteoclast-Mediated Bone Loss
    Lianping Xing; Fiscal Year: 2012
    ..But its role in osteoclast function has not been investigated and little is known about the role of the lymphatic system in the pathogenesis of joint destruction in RA...
  14. Role of a9b1 Integrin in lymphangiogenesis
    Nicholas E Vlahakis; Fiscal Year: 2010
    ..To date the biology of the lymphatic system has largely been ignored, however recently it has become clear this has been a mistake since human diseases ..
  15. Failure of metabolite clearance in a model of multi-lacunar infarcts
    Maiken Nedergaard; Fiscal Year: 2013
    ..which we designate the 'glymphatic system'- subserves a function homologous to the peripheral lymphatic system, and is essential for the clearance of metabolic waste products from the CNS...
  16. SYNTHESIS AND BIOTRANSFORMATION OF ANTI-HIV PRODRUGS
    Chung K Chu; Fiscal Year: 2010
    ..In order to further improve the potency, bioavailability, and selective targeted delivery to the lymphatic system and brain, we propose several prodrugs of DAPD...
  17. The glymphatic system, a new concept in glia biology
    Maiken Nedergaard; Fiscal Year: 2013
    Virtually unique among somatic tissues, the brain and spinal cord lack a lymphatic system. Despite the high metabolic activity and fragility of neural tissue, there exists no effective understanding of the means by which interstitial ..
  18. Quantifying the role of load-induced remodeling in lymphedema progression
    JAMES BRANDON DIXON; Fiscal Year: 2013
    ..altering the tissue microenvironment and further compromising fluid, protein, and lipid transport by the lymphatic system. This hypothesis will be tested through two Specific Aims: 1) Quantify the growth and remodeling response of ..
  19. Therapeutic Lymphatic Collecting Vessel Regeneration by Directed Fluid Flow
    Jeremy Goldman; Fiscal Year: 2012
    ..Because swelling of the arm follows injury to the lymphatic system, it has been hypothesized that increased lymphatic growth via growth factor mediated lymphangiogenesis of the ..
  20. The Role of Lymphangiogenesis in IBD Pathogenesis
    Claudio Fiocchi; Fiscal Year: 2013
    ..In particular, the lymphatic system is closely associated with the immune response by providing an extensive network of vessels responsible for ..
  21. Microparticle Capture-Based Analysis of Lymph Node Proteome
    Serguei Popov; Fiscal Year: 2013
    ..pestis, F. tularenis, and B. anthracis. In the case of B. anthracis, the lymphatic system serves as the conduit by which germinating spores are delivered by macrophages to the sentinel lymph nodes (..
  22. Mechanisms of Lymphatic Pump-Enhancement of Immune Function
    LISA MICHELLE HODGE; Fiscal Year: 2012
    ..In addition, this new information will expand basic understanding of the lymphatic system and its role in immunological function...
  23. Atherogenic role of T cell modulation by intestinal bacteria
    Debbie Beasley; Fiscal Year: 2013
    ..development within the intestinal wall of IL-17-expressing T cells, which are then mobilized into the lymphatic system and recruited to sites of aortic inflammation, where they act locally by producing IL-17 and IFN-?, which ..
  24. Quantification of HIV Reservoirs in the Gut-Associated Lymphatic System
    Steven Yukl; Fiscal Year: 2013
    ..The knowledge thus gained may ultimately contribute to new and improved therapies aimed at eradication or lifelong coexistence with HIV. ..
  25. Mechanisms of fibrosis and lymphatic dysfunction in post-surgical lymphedema
    BABAK MEHRARA MEHRARA; Fiscal Year: 2013
    ..the working hypothesis that impaired lymphatic function secondary to fibrosis is a consequence of indirect effects of T-cells and Th2 cytokines on the lymphatic system rather than down-regulation of lymphangiogenic cytokine expression.
  26. Development of Robust Culture Systems for the Human Splenic Littoral Cell
    JOYCE DIANE FINGEROTH; Fiscal Year: 2013
    ..overall organization of splenic white pulp is similar to that of lymph nodes, spleen is not connected to the lymphatic system. Instead, pathogens, RBCs, apoptotic/necrotic, altered and tumor cells all are delivered to and leave the ..
  27. Melatonin: pacemaker for nocturnal periodicity of microfilarial parasites
    JEFFERSON ARCHER VAUGHAN; Fiscal Year: 2012
    ..It is caused by filarial nematodes (Wuchereria bancrofti and Brugia malayi) that inhabit the lymphatic system. To perpetuate their life cycle, inseminated adult female worms produce millions of microfilariae (mf) that ..
  28. The Six1/Eya Transcriptional complex as a mediator of lymphangiogenesis and lymph
    Heide L Ford; Fiscal Year: 2013
    ..Spread of cancer cells occurs via blood vessels or, particularly important for breast cancer, via the lymphatic system. Although tumor dissemination via the blood has been extensively studied, the mechanisms that lead to ..
  29. Targeted Chemoprevention for Melanoma
    Gavin P Robertson; Fiscal Year: 2013
    ..chemopreventive agents exist to inhibit this cancer in its earliest forms or when cells are present in the lymphatic system in the proximity of the early primary lesion...
  30. Comparative In Vivo Biodistribution of Characterized Manufactured Nanomaterials
    Nancy A Monteiro Riviere; Fiscal Year: 2010
    ..In addition, we will specifically probe the involvement of the lymphatic system in MNM absorption and translocation...
  31. Prox1 in Mammalian Lymphangiogenesis
    GUILLERMO C OLIVER; Fiscal Year: 2013
    ..Malfunctions of the lymphatic system can lead to congenital or inherited disorders such as lymphedema, a disfiguring and disabling disorder that ..
  32. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2007
    The hereditary lymphedemas are developmental disorders of the lymphatic system that lead to disfiguring and often disabling edema (swelling) of the extremities together with various associated abnormalities...
  33. Ionic Mechanisms of Stretch-Activation in Muscular Lymphatics
    DAVID CARL ZAWIEJA; Fiscal Year: 2012
    To fulfill the roles the lymphatic system plays in body fluid regulation, macromolecular homeostasis, lipid absorption, immune function, it must transport lymph from the interstitium, along the lymphatic network, through the nodes, into ..
  34. 2010 Molecular Mechanisms in Lymphatic Function and Disease Gordon Research Confe
    Michael J Detmar; Fiscal Year: 2010
    ..into the mechanisms that control the function of the lymphatic vascular system, and into the role of the lymphatic system in human disease have experienced a dramatic growth within the last 10 years, largely due to the development ..
  35. Cyber Informatics Tools for Lymphedema Stakeholders
    Chi Ren Shyu; Fiscal Year: 2012
    ..to improve outcomes for patients with and at risk for lymphedema (LE), a chronic, progressive disease of the lymphatic system, often starting with seemingly innocuous superficial swelling of a limb which progresses to a distressing, ..
  36. Lymphatic Fluid Flow Modeling with Active Network Components
    James E Moore; Fiscal Year: 2012
    Summary The lymphatic system performs many crucial functions in health, gathering approximately 4 liters/day of interstitial fluid and returning it to the venous system...
  37. MASSAGE THERAPY FOR EXPERIMENTAL LYMPHEDEMA
    Marlys Witte; Fiscal Year: 2002
    ..practical standardized LE animal model for detailed delineation of physiologic mechanisms/effects in the lymphatic system, and (lymph)edema postulated for a wide array of inadequately tested alternative/complementary approaches (e...
  38. SYNDECAN FUNCTION IN ENDOTHELIAL CELLS
    Michael Simons; Fiscal Year: 2013
    ..Taken together these studies for the first time will paint a comprehensive picture of molecular signaling events and linked physical forces that underlie formation of the lymphatic system.
  39. MECHANISMS INVOLVED IN LYMPHATIC CONTRACTILE ACTIVITY
    David Zawieja; Fiscal Year: 2000
    ..level of understanding about the roles and mechanisms of an important but poorly understood organ system, the lymphatic system. My immediate career objectives are to: establish a reputation for independent, quality scientific studies; ..
  40. Short-term mesenteric lymphatic adaptation to trauma-related intestinal edema
    Emily Wilson; Fiscal Year: 2010
    ..The mesenteric lymphatic system plays a crucial role in limiting bowel edema by returning interstitial fluid to the blood stream...
  41. Physical Activity and Lymphedema Project (PAL Trial)
    Kathryn Schmitz; Fiscal Year: 2007
    ..daily living that require strenuous upper body work (shoveling snow, carrying children) would over-stress the lymphatic system. This proposal stems from compelling preliminary data from a 6 month randomized controlled trial of ..
  42. ENHANCED THERAPY RESPONSE IN OSTEOSARCOMA
    GENE DIRESTA; Fiscal Year: 2001
    ..Tumors lack a functioning lymphatic system. Fluid buildup from leaky tumor capillaries is responsible for elevated IFP...
  43. PDAC-on-a-Chip for Selection of Aggressive, Therapy-Resistant Tumor Cells
    MICHAEL GAMCSIK; Fiscal Year: 2013
    ..into a secondary oxygen-rich 'circulatory compartment'that mimics the tumor blood vessel or lymphatic system. The oxygen shock experienced by invasive cells further selects for circulation-viable cells likely ..
  44. Mechanisms That Mediate The Absence of Lymphatics in the Retina
    PATRICIA D AMORE; Fiscal Year: 2009
    The lymphatic system plays a dual role: 1) draining interstitial fluid from tissues and returning it to the blood and, 2) participating in the immune response...
  45. FETAL LYMPH FLOW DYNAMICS AND CONTROL
    ROBERT BRACE; Fiscal Year: 1993
    ..Data generated thus far show that the lymphatic system in the fetus is uniquely different from that in the adult in that lymph flow rates and lymph protein fluxes ..
  46. TREATMENT OF MALIGNANT PLEURAL EFFUSIONS
    Roman Perez Soler; Fiscal Year: 1993
    ..body cavities tend to remain for a prolonged period of time inside the cavity and are mainly drained by the lymphatic system. This may enhance the therapeutic effects of drugs incorporated in liposomes inside the cavity and in the ..
  47. PHYSIOLOGY OF RECOVERY FROM INTERSTITIAL PULMONARY EDEMA
    E Jerome; Fiscal Year: 1990
    ..interstitial edema to lung lymph flow, to test the hypothesis that there is little clearance via the lymphatic system. The data we obtain will clarify, quantitatively, the role of various pathways of lung interstitial liquid ..
  48. Genes important in breast cancer metastasis
    Robin Anderson; Fiscal Year: 2003
    ..Metastasis is a complex process in which cells migrate from the primary tumor to the blood or lymphatic system and hence to distant sites. Many cellular changes and interactions are required during this process...
  49. A Lymphatic-specific fluorescent transgenic model
    Young Kwon Hong; Fiscal Year: 2007
    ..generation of a transgenic mouse line that expresses the red fluorescent protein (RFP) specifically in the lymphatic system. We plan to achieve this goal by undertaking 2 separate approaches...
  50. SYNTHESIS AND BIOTRANSFORMATION OF ANTIHIV PRODRUGS
    David Chu; Fiscal Year: 2000
    ..There are at least two other major compartments which should be considered: the central nervous and the lymphatic system. In this application, Dr...
  51. The role of FoxM1 in pancreatic cancer
    Andrei Gartel; Fiscal Year: 2009
    ..cancer is very deadly, because it is resistant to conventional treatments and it rapidly disseminates to the lymphatic system and remote organs...
  52. "MSM" A multi-scale approach for understanding antigen presentation in immunity
    Denise Kirschner; Fiscal Year: 2007
    ..structured environment of the lymph node and ultimately by external compartmental dynamics of blood and the lymphatic system. A comprehensive understanding of the process of antigen presentation during an immune response will require ..
  53. Evaluation of Lymph Flow and Function
    David Zawieja; Fiscal Year: 2009
    ..Because our understanding of many basic functions of the lymphatic system is still quite rudimentary, lymphatic involvement in these disease processes is grossly understudied making ..
  54. MICROVASCULAR CONTROL--VASCULARITY AND FLUID ENVIRONMENT
    THOMAS ADAIR; Fiscal Year: 1992
    ..on two major aspects of the microcirculation: (1) regulation of blood vessel growth, and (2) function of the lymphatic system. Strong support now exists for the metabolic theory of angiogenesis...
  55. CONQUERING LYMPHATIC DISEASE--SETTING THE RESEARCH AGEND
    Marlys Witte; Fiscal Year: 2000
    ..System will foster adoption of varied basic and clinical research approaches that put the lymphatic system in perspective with regard to other body systems and its impact on the person; 3) Year 5-Building the ..
  56. Genital Herpes Vaccine Discovery
    Gary Fujii; Fiscal Year: 2007
    ..The small size of the liposomes ensures that they will readily distribute throughout the lymphatic system when administered subcutaneously resulting in high concentrations of antigen in immune tissues which should ..
  57. THE ORIGIN AND FORMATION OF RENAL LYMPH
    CHARLES O MORCHOE; Fiscal Year: 1980
    Studies concerning the structure and function of the renal lymphatic system are proposed...
  58. GENETIC STUDIES OF LYMPHEDEMA
    David Finegold; Fiscal Year: 2002
    ..These studies will ultimately lead to a better understanding of the developmental biology of the lymphatic system, and provide a means of identifying high risk individuals in lymphedema families, as well as the normal ..
  59. FLUID EXCHANGE IN EDEMATOUS LUNGS
    Robert Drake; Fiscal Year: 1992
    ..The proposed studies should help to define the role of the pulmonary lymphatic system in the pulmonary edema caused by endotoxin.
  60. MODULATION OF LEYDIG CELL FUNCTION BY INTERLEUKIN-1
    Tu Lin; Fiscal Year: 1991
    ..of a variety of cell types including Leydig cells, macrophages, fibroblasts and components of the blood and lymphatic system. In rats, testicular macrophages represent about 20% of the interstitial tissue profile in histologic ..
  61. Pressure stimulated cell adhesion
    Marc Basson; Fiscal Year: 2009
    ..we have shown that increased extracellular pressure, such as may occur during passage through the venous or lymphatic system, during surgical procedures, or postoperatively due to increased intra-abdominal pressure, stimulates FAK-Src ..
  62. Lymphatic targeted tamoxifen for breast cancer therapy
    Nandita Das; Fiscal Year: 2003
    ..of this novel lymphatic targeted drug delivery system could provide a radical improvement in breast cancer treatment with TAM, with possible implications in reducing metastatic potential, as metastasis occurs via the lymphatic system.
  63. International Symposium on Cancer Metastasis and the Lymphovascular System
    STANLEY LEONG; Fiscal Year: 2007
    ..Whether the cancer spreads through the lymphatic system initially (incubator hypothesis) or simultaneosly through the lymphatic and vascular system (marker ..
  64. EMBRYONIC ORIGIN OF LYMPHATIC HEART MUSCLE MYOBLASTS
    GARY RADICE; Fiscal Year: 1999
    ..to skeletal, smooth and cardiac muscle, many animals have an unusual muscle in the beating hearts of the lymphatic system (LHM muscle)...
  65. Next Generation Gamma Detector Arrays for High Resoluti*
    M CAPOTE; Fiscal Year: 2002
    ..applications are mammography, clinical cardiology, in vivo auto radiography, neuroscience studies, and lymphatic system imaging. There exists a huge potential for in vivo expression studies in small animals...
  66. Solid State Gamma Ray Imaging Detectors, Novel Packaging
    M CAPOTE; Fiscal Year: 2003
    ..applications are mammography, clinical cardiology, in vivo auto radiography, neuroscience studies, and lymphatic system imaging. There exists a huge potential for in vivo gene expression studies in small animals...