immune system

Summary

Summary: The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.

Top Publications

  1. pmc Myeloid-derived suppressor cells as regulators of the immune system
    Dmitry I Gabrilovich
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Nat Rev Immunol 9:162-74. 2009
  2. pmc Interactions between the microbiota and the immune system
    Lora V Hooper
    The Howard Hughes Medical Institute and Department of Immunology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Science 336:1268-73. 2012
  3. ncbi An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    Sarkis K Mazmanian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:107-18. 2005
  4. ncbi NF-kappaB regulation in the immune system
    Qiutang Li
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Immunol 2:725-34. 2002
  5. doi The immune system in atherosclerosis
    Goran K Hansson
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Nat Immunol 12:204-12. 2011
  6. pmc Peripheral education of the immune system by colonic commensal microbiota
    Stephanie K Lathrop
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 478:250-4. 2011
  7. pmc Human nutrition, the gut microbiome and the immune system
    Andrew L Kau
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 474:327-36. 2011
  8. pmc The many roles of FAS receptor signaling in the immune system
    Andreas Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Immunity 30:180-92. 2009
  9. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
  10. doi Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions
    Pascal Gourbeyre
    INRA, UR1268, Unite de recherche sur les Biopolyme res, leurs Interactions et Assemblages, Nantes, France
    J Leukoc Biol 89:685-95. 2011

Detail Information

Publications376 found, 100 shown here

  1. pmc Myeloid-derived suppressor cells as regulators of the immune system
    Dmitry I Gabrilovich
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Nat Rev Immunol 9:162-74. 2009
    ..These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases...
  2. pmc Interactions between the microbiota and the immune system
    Lora V Hooper
    The Howard Hughes Medical Institute and Department of Immunology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Science 336:1268-73. 2012
    ..numbers of microorganisms that inhabit mammalian body surfaces have a highly coevolved relationship with the immune system. Although many of these microbes carry out functions that are critical for host physiology, they nevertheless ..
  3. ncbi An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    Sarkis K Mazmanian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:107-18. 2005
    ..tract harbors a complex ecosystem consisting of countless bacteria in homeostasis with the host immune system. Shaped by evolution, this partnership has potential for symbiotic benefit...
  4. ncbi NF-kappaB regulation in the immune system
    Qiutang Li
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Immunol 2:725-34. 2002
    ..In this review, we focus on our current understanding of NF-kappaB regulation and its role in the immune system and inflammatory diseases...
  5. doi The immune system in atherosclerosis
    Goran K Hansson
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Nat Immunol 12:204-12. 2011
    ..Studies are now under way to develop new therapies based on these concepts of the involvement of the immune system in atherosclerosis.
  6. pmc Peripheral education of the immune system by colonic commensal microbiota
    Stephanie K Lathrop
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 478:250-4. 2011
    The instruction of the immune system to be tolerant of self, thereby preventing autoimmunity, is facilitated by the education of T cells in a specialized organ, the thymus, in which self-reactive cells are either eliminated or ..
  7. pmc Human nutrition, the gut microbiome and the immune system
    Andrew L Kau
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 474:327-36. 2011
    ..composition and dynamic operations of our gut microbial communities, and the innate and adaptive arms of our immune system, represents an area of scientific need, opportunity and challenge...
  8. pmc The many roles of FAS receptor signaling in the immune system
    Andreas Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Immunity 30:180-92. 2009
    ..Studies with mutant mice and cells from human patients have shown that FAS plays critical roles in the immune system, including the killing of pathogen-infected cells and the death of obsolete and potentially dangerous ..
  9. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
    To maintain immune homeostasis, the intestinal immune system has evolved redundant regulatory strategies. In this regard, the gut is home to a large number of regulatory T (T reg) cells, including the Foxp3(+) T reg cell...
  10. doi Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions
    Pascal Gourbeyre
    INRA, UR1268, Unite de recherche sur les Biopolyme res, leurs Interactions et Assemblages, Nantes, France
    J Leukoc Biol 89:685-95. 2011
    ..They may therefore be tools that can prevent or alleviate certain pathologies involving the gut immune system, such as allergies for which no treatment is yet available...
  11. doi Obesity, inflammation and the immune system
    Fátima Pérez de Heredia
    Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition of the Spanish National Research Council ICTAN CSIC, Madrid, Spain
    Proc Nutr Soc 71:332-8. 2012
    ..The chronic inflammatory response has its origin in the links existing between the adipose tissue and the immune system. Obesity, like other states of malnutrition, is known to impair the immune function, altering leucocyte counts ..
  12. pmc The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    Stephan Gasser
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Nature 436:1186-90. 2005
    Some stimulatory receptors of the innate immune system, such as the NKG2D receptor (also called KLRK1) expressed by natural killer cells and activated CD8(+)T cells, recognize self-molecules that are upregulated in diseased cells by ..
  13. pmc The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
    A Ozinsky
    Department of Immunology, University of Washington, H 574 Health Sciences, Box 357650, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:13766-71. 2000
    Toll-like receptors (TLRs) have been shown to participate in the recognition of pathogens by the innate immune system, but it is not clear how a restricted family of receptors has the capacity to recognize the wide spectrum of TLR ..
  14. ncbi Innate immunity of the newborn: basic mechanisms and clinical correlates
    Ofer Levy
    Department of Medicine, Division of Infectious Diseases, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Nat Rev Immunol 7:379-90. 2007
    ..These demands shape a distinct neonatal innate immune system that is biased against the production of pro-inflammatory cytokines...
  15. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo.
  16. doi Heat shock proteins and immune system
    Min Fu Tsan
    Office of Research Oversight, Department of Veterans Affairs, 50 Irving Street, N W, Washington, DC 20422, USA
    J Leukoc Biol 85:905-10. 2009
    ..The reported antigen presentation and cross-presentation and in vitro HSP cytokine functions are a result of molecules bound to or chaperoned by HSPs but not a result of HSPs themselves...
  17. doi Programmed necrosis: backup to and competitor with apoptosis in the immune system
    Jiahuai Han
    State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China
    Nat Immunol 12:1143-9. 2011
    Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli...
  18. ncbi Molecular identification of a danger signal that alerts the immune system to dying cells
    Yan Shi
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Nature 425:516-21. 2003
    In infections, microbial components provide signals that alert the immune system to danger and promote the generation of immunity. In the absence of such signals, there is often no immune response or tolerance may develop...
  19. pmc Vitamin effects on the immune system: vitamins A and D take centre stage
    J Rodrigo Mora
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 8:685-98. 2008
    Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and ..
  20. ncbi Propolis and the immune system: a review
    J M Sforcin
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618 000 Botucatu, SP, Brazil
    J Ethnopharmacol 113:1-14. 2007
    ..provided new information concerning its mechanisms of action, thus a review dealing with propolis and the immune system became imperative...
  21. pmc Circadian control of the immune system
    Christoph Scheiermann
    Ruth L and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Rev Immunol 13:190-8. 2013
    ..Circadian oscillations of immune mediators coincide with the activity of the immune system, possibly allowing the host to anticipate and handle microbial threats more efficiently...
  22. doi Vitamin D metabolism and signaling in the immune system
    John H White
    Department of Physiology, McGill University, McIntyre Bldg, Rm 1112, 3655 Drummond St, Montreal, QC, H3G 1Y6, Canada
    Rev Endocr Metab Disord 13:21-9. 2012
    ..regulator of human physiology, and recent work has revealed that it has several roles in control of human immune system function...
  23. doi The role of the immune system in the generation of neuropathic pain
    Margarita Calvo
    Department of Neurorestoration, Wolfson CARD, King s College London, London, UK
    Lancet Neurol 11:629-42. 2012
    ..This response involves the innate immune system, but evidence also exists of T-lymphocyte recruitment, and in some patient cohorts antibodies to neuronal ..
  24. doi Emerging role of high density lipoproteins as a player in the immune system
    Giuseppe Danilo Norata
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Italy
    Atherosclerosis 220:11-21. 2012
    ..of HDL in immunity could be related, to either the ability of HDL to modulate cholesterol content in immune cell lipid rafts and to their role as reservoir for several biologically active substances that may impact the immune system.
  25. pmc Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
    Fumihiko Ishikawa
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, no 770, Boston, MA 02115, USA
    Blood 106:1565-73. 2005
    ..Thus, the NOD/SCID/IL2rgamma(null) newborn system might be an important experimental model to study the human hemato-lymphoid system...
  26. ncbi A review of the multiple actions of melatonin on the immune system
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Seville, Spain
    Endocrine 27:189-200. 2005
    ..which have shown that one of the most significant of melatonin's pleiotropic effects is the regulation of the immune system. The overview summarizes the immune effects of pinealectomy and the association between rhythmic melatonin ..
  27. ncbi Regulation of JAK-STAT signalling in the immune system
    Ke Shuai
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Immunol 3:900-11. 2003
  28. pmc Comparative genomic analysis of the Tribolium immune system
    Zhen Zou
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Genome Biol 8:R177. 2007
    ..Components of the innate immune system are hardly known in this insect, which is in a key phylogenetic position to inform us about genetic ..
  29. pmc In vitro reconstitution of an Escherichia coli RNA-guided immune system reveals unidirectional, ATP-dependent degradation of DNA target
    Sabin Mulepati
    Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 288:22184-92. 2013
    ..Following nicking and powered by ATP hydrolysis, the concerted actions of the helicase and nuclease domains of Cas3 proceed to unwind and degrade the entire DNA target in a unidirectional manner. ..
  30. ncbi Glycosylation and the immune system
    P M Rudd
    The Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Science 291:2370-6. 2001
    ..In the cellular immune system, specific glycoforms are involved in the folding, quality control, and assembly of peptide-loaded major ..
  31. doi Regulation and function of NF-kappaB transcription factors in the immune system
    Sivakumar Vallabhapurapu
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Cancer Center, University of California, San Diego, California 93093, USA
    Annu Rev Immunol 27:693-733. 2009
    ..p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs ..
  32. doi The role of interleukin-2 during homeostasis and activation of the immune system
    Onur Boyman
    Laboratory of Applied Immunobiology, University of Zurich, Gloriastrasse 30, CH 8006 Zurich, Switzerland
    Nat Rev Immunol 12:180-90. 2012
    ....
  33. doi Direct effects of type I interferons on cells of the immune system
    Sandra Hervas-Stubbs
    Division of Gene Therapy and Hepatology, Centre for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    Clin Cancer Res 17:2619-27. 2011
    ..Recently, mouse experiments have shown that IFNs-I directly activate other cells of the immune system, such as antigen-presenting dendritic cells (DC) and CD4 and CD8 T cells...
  34. pmc A decade of imaging cellular motility and interaction dynamics in the immune system
    Ronald N Germain
    Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 336:1676-81. 2012
    ..Here, we review themes emerging from such studies and speculate on the future of immunoimaging...
  35. pmc Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
    Mol Pharm 5:487-95. 2008
    ..We will also provide an overview of in vitro methods useful in identifying interactions with components of the immune system and the potential effects of such interaction on particle distribution to tissues.
  36. pmc Quantifying adaptive evolution in the Drosophila immune system
    Darren J Obbard
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK
    PLoS Genet 5:e1000698. 2009
    ..These patterns appear to be general features of immune system evolution in both species, as rates of adaptive evolution are correlated between the D. melanogaster and D...
  37. pmc Arginase: an emerging key player in the mammalian immune system
    Markus Munder
    Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany
    Br J Pharmacol 158:638-51. 2009
    ..Besides its fundamental role in the hepatic urea cycle, arginase is also expressed the immune system of mice and man...
  38. ncbi Arthritis critically dependent on innate immune system players
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Immunity 16:157-68. 2002
    ..We suggest that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response...
  39. ncbi Experimental stroke induces massive, rapid activation of the peripheral immune system
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 26:654-65. 2006
    Clinical experimental stroke induces injurious local brain inflammation. However, effects on the peripheral immune system have not been well characterized...
  40. ncbi Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system
    Ralph M Steinman
    The Rockefeller University, 1230 York Avenue, New York, New York 10065 6399, USA
    Nat Med 13:1155-9. 2007
  41. pmc Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    J Psychiatry Neurosci 34:4-20. 2009
    Activation of the inflammatory immune system provokes numerous neuroendocrine and neurotransmitter changes, many of which are similar to those provoked by physical or psychological stressors...
  42. pmc Complexity of dendritic cell subsets and their function in the host immune system
    Rahul Kushwah
    Physiology and Experimental Medicine Research Program, Hospital for Sick Children, Toronto, ON, Canada
    Immunology 133:409-19. 2011
    ..We classify DCs derived from common DC progenitor and pre-DC populations as conventional DCs, which includes both migratory and lymphoid-resident DC subsets and classify monocyte-derived DCs and plasmacytoid DCs as non-conventional DCs...
  43. ncbi Atopic disease, immune system, and the environment
    Salvatore Leonardi
    Department of Pediatrics, Catania University, Catania, Italy
    Allergy Asthma Proc 28:410-7. 2007
    ..The purpose of this study is to review recent knowledge concerning the developing human immune system and its interaction with external environmental factors for a better understanding of the changing faces of ..
  44. doi Micromanagement of the immune system by microRNAs
    Harvey F Lodish
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Immunol 8:120-30. 2008
    ..Here, we provide an overview of the mechanisms by which miRNAs regulate gene expression, with specific focus on the role of miRNAs in regulating the development of immune cells and in modulating innate and adaptive immune responses...
  45. pmc Priming of protective T cell responses against virus-induced tumors in mice with human immune system components
    Till Strowig
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1423-34. 2009
    ..We demonstrate that primary T cell responses in mice with reconstituted human immune system components control infection with the oncogenic and persistent Epstein-Barr virus (EBV)...
  46. doi The aging of the immune system
    Daniela Weiskopf
    Immunology Division, Institute for Biomedical Aging Research, Innsbruck, Austria
    Transpl Int 22:1041-50. 2009
    ..Age-dependent defects in T- and B-cell function coexist with age-related changes within the innate immune system. In this review, we discuss the mechanisms and consequences of age-associated immune alterations as well as ..
  47. pmc Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
    Lesley Jones
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom
    PLoS ONE 5:e13950. 2010
    ..We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes...
  48. pmc Regulatory interactions between muscle and the immune system during muscle regeneration
    James G Tidball
    Molecular, Cellular and Integrative Physiology Program, Department of Integrative Biology and Physiology, University of California Los Angeles, CA 90095 1606, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1173-87. 2010
    Recent discoveries reveal complex interactions between skeletal muscle and the immune system that regulate muscle regeneration...
  49. pmc Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology
    Richard M Ransohoff
    Neuroinflammation Research Center Lerner Research Institute and Mellen Center for MS Treatment and Research Neurological Institute, Cleveland Clinic, Mail Code NC30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Immunity 31:711-21. 2009
    ..The challenge is to integrate knowledge of the roles of key receptors (as well as their ligands) into a coherent account of events during pathologic processes, in order to guide therapeutic development...
  50. ncbi Involvement of the choroid plexus in central nervous system inflammation
    B Engelhardt
    Max Planck Institut fur Physiologische und Klinische Forschung, W G Kerckhoff Institut, Bad Nauheim, Germany
    Microsc Res Tech 52:112-29. 2001
    ..Taken together, our observations imply a previously unappreciated function of the choroid plexus in the immunosurveillance of the CNS...
  51. ncbi Gender differences in the development and function of the immune system
    Richard S Shames
    Division of Allergy and Clinical Immunology, Stanford University Medical Center, Stanford, California 94305 5208, USA
    J Adolesc Health 30:59-70. 2002
  52. doi MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death
    R Schickel
    The Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Oncogene 27:5959-74. 2008
    ..miRNAs control various activities of the immune system and different stages of hematopoietic development, and their misexpression is the cause of various blood ..
  53. pmc Cell type-specific DNA methylation at intragenic CpG islands in the immune system
    Aimée M Deaton
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    Genome Res 21:1074-86. 2011
    ..Altered DNA methylation in the immune system occurred predominantly at CGIs within gene bodies, which have the properties of cell type-restricted promoters,..
  54. pmc Origin and evolution of the adaptive immune system: genetic events and selective pressures
    Martin F Flajnik
    Department of Microbiology and Immunology, University of Maryland at Baltimore, Baltimore, Maryland 21201, USA
    Nat Rev Genet 11:47-59. 2010
    The adaptive immune system (AIS) in mammals, which is centred on lymphocytes bearing antigen receptors that are generated by somatic recombination, arose approximately 500 million years ago in jawed fish...
  55. pmc CD8(+) T cells: foot soldiers of the immune system
    Nu Zhang
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Immunity 35:161-8. 2011
    ..Here we review recent advances in CD8(+) T cell recognition of antigen in lymphoid as well as in nonlymphoid tissues in the periphery, and how CD8(+) T cell expansion and differentiation are controlled in these contexts...
  56. doi Malignant pirates of the immune system
    Lixin Rui
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:933-40. 2011
    ....
  57. pmc Aging of the innate immune system
    Albert C Shaw
    Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, 300 Cedar St Box 208022, New Haven, CT 06520, USA
    Curr Opin Immunol 22:507-13. 2010
    The innate immune system is composed of a network of cells including neutrophils, NK and NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions with pathogens...
  58. pmc MicroRNA in the immune system, microRNA as an immune system
    Li Fan Lu
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Immunology 127:291-8. 2009
    ..In the immune system, microRNA appear to have a key role in the early differentiation and effector differentiation of B cells...
  59. pmc The immune system and cardiac repair
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Baylor College of Medicine, One Baylor Plaza BCM620, Houston, TX 77030, United States
    Pharmacol Res 58:88-111. 2008
    ..In addition, understanding the role of the immune system in cardiac repair is necessary in order to design optimal strategies for cardiac regeneration.
  60. pmc Stromal cell contributions to the homeostasis and functionality of the immune system
    Scott N Mueller
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010 Victoria, Australia
    Nat Rev Immunol 9:618-29. 2009
    A defining characteristic of the immune system is the constant movement of many of its constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph nodes, where crucial interactions that underlie homeostatic ..
  61. pmc Vitamin D and the immune system: new perspectives on an old theme
    Martin Hewison
    Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Endocrinol Metab Clin North Am 39:365-79, table of contents. 2010
    Interaction with the immune system is one of the most well-established nonclassic effects of vitamin D...
  62. doi The cellular and signaling networks linking the immune system and metabolism in disease
    Olivia Osborn
    Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, La Jolla, California, USA
    Nat Med 18:363-74. 2012
    ..to type 2 diabetes and cardiovascular disease, and a number of studies have clearly demonstrated that the immune system and metabolism are highly integrated...
  63. doi Regulatory B cells play a key role in immune system balance
    Jean Marie Berthelot
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Joint Bone Spine 80:18-22. 2013
    ..Research into the interactions between the gut microbiota and Bregs holds considerable promise...
  64. ncbi Glutamine and the immune system
    P C Calder
    Institute of Human Nutrition, University of Southampton, United Kingdom
    Amino Acids 17:227-41. 1999
    Glutamine is utilised at a high rate by cells of the immune system in culture and is required to support optimal lymphocyte proliferation and production of cytokines by lymphocytes and macrophages...
  65. doi The effects of ghrelin on inflammation and the immune system
    Dolgor Baatar
    Laboratory of Molecular Biology and Immunology, NIA IRP, NIH, Biomedical Research Center, Baltimore, MD 21224, USA
    Mol Cell Endocrinol 340:44-58. 2011
    ..The functional roles of ghrelin and other growth hormone secretagogues (GHS) within the immune system and under states of inflammatory stress and injury are only now coming to light...
  66. ncbi Evolution of the mammary gland from the innate immune system?
    Claudia Vorbach
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria
    Bioessays 28:606-16. 2006
    ..Therefore, we postulate that the mammary gland evolved from the innate immune system. In addition, we suggest that lactation partly evolved as an inflammatory response to tissue damage and ..
  67. doi Modulation of the immune system by UV radiation: more than just the effects of vitamin D?
    Prue H Hart
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, PO Box 855, Perth, Western Australia 6872, Australia
    Nat Rev Immunol 11:584-96. 2011
    ..Here, we compare and contrast the effects of UV radiation and vitamin D on immune function in immunopathological diseases, such as psoriasis, multiple sclerosis and asthma, and during infection...
  68. doi Interactions of nanomaterials with the immune system
    Salik Hussain
    Unit of Functional and Adaptive Biology, Laboratory of Molecular and Cellular Responses to Xenobiotics, Universite Paris Diderot, Paris, France
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:169-83. 2012
    ..Various nanomaterials interact with the immune system, in a beneficial or deleterious way, but mechanistic details about such interactions are scarce...
  69. pmc The case of oncolytic viruses versus the immune system: waiting on the judgment of Solomon
    Robin J Prestwich
    Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, United Kingdom
    Hum Gene Ther 20:1119-32. 2009
    The three-way interaction between oncolytic viruses, the tumor microenvironment, and the immune system is critical to the outcome of antitumor therapy...
  70. doi An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of Phase II and III clinical trials
    M Ligueros-Saylan
    Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
    Diabetes Obes Metab 12:495-509. 2010
    ..To assess the safety of vildagliptin versus all comparators (ACs) with regard to organs, systems or tissues of particular interest in type 2 diabetes (T2DM) and areas of potential concern with dipeptidyl peptidase-IV (DPP-4) inhibitors...
  71. ncbi Danger signals: SOS to the immune system
    S Gallucci
    Ghost Laboratory, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 111, Bethesda, MD 20892, USA
    Curr Opin Immunol 13:114-9. 2001
    ....
  72. pmc From inflammation to sickness and depression: when the immune system subjugates the brain
    Robert Dantzer
    Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
    Nat Rev Neurosci 9:46-56. 2008
    ..When activation of the peripheral immune system continues unabated, such as during systemic infections, cancer or autoimmune diseases, the ensuing immune ..
  73. doi MicroRNA control in the immune system: basic principles
    Changchun Xiao
    Immune Disease Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Cell 136:26-36. 2009
    MicroRNA (miRNA) control has emerged as a critical regulatory principle in the mammalian immune system. Genetic ablation of the miRNA machinery, as well as loss or deregulation of certain individual miRNAs, severely compromises immune ..
  74. pmc The immune system in pregnancy: a unique complexity
    Gil Mor
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, School of Medicine, Yale University, New Haven, CT 06520, USA
    Am J Reprod Immunol 63:425-33. 2010
    ....
  75. doi Autophagy and the immune system
    Petric Kuballa
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA
    Annu Rev Immunol 30:611-46. 2012
    ..In this review, we discuss the mechanisms by which autophagy is regulated, as well as the functions of autophagy and autophagy proteins in immunity and inflammation...
  76. pmc Immune-neural connections: how the immune system's response to infectious agents influences behavior
    Robert H McCusker
    Integrative Immunology and Behavior Program, Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801 3873, USA
    J Exp Biol 216:84-98. 2013
    ..g. nucleotide-binding oligomerization domain (Nod)-like receptors] of cells of the innate immune system, primarily macrophages and dendritic cells...
  77. ncbi Activation of the mucosal immune system in irritable bowel syndrome
    Vinton S Chadwick
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, New Zealand
    Gastroenterology 122:1778-83. 2002
    A role for the mucosal immune system in the pathogenesis of irritable bowel syndrome is suggested by its association with intestinal infections.
  78. ncbi Neuropilin-1 in the immune system
    Paul Henri Romeo
    Institut Cochin, Département Hématologie, INSERM U567, CNRS UMR 8104, Maternite Port Royal, 123 Boulevard de Port Royal, 75014 Paris, France
    Adv Exp Med Biol 515:49-54. 2002
    ..These results emphasize the molecular similarities between the nervous and the immune systems and open new areas in the modulation of the immune response...
  79. ncbi Forkhead-box transcription factors and their role in the immune system
    Paul J Coffer
    Department of Pulmonary Diseases, University Medical Centre, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Nat Rev Immunol 4:889-99. 2004
    ..This review focuses on FOXP3, FOXN1, FOXJ1 and members of the FOXO subfamily and their function in the immune system.
  80. ncbi The immune system in extreme longevity
    P Sansoni
    Dipartimento di Medicina Interna e Scienze Biomediche, Universita di Parma, Via Gramsci 14, 43100 Parma, Italy
    Exp Gerontol 43:61-5. 2008
    ..In addition, it appears that the ancestral/innate compartment of the immune system is relatively preserved during aging in comparison to the more recent and sophisticated adaptive compartment ..
  81. doi Aging of the immune system as a prognostic factor for human longevity
    Anis Larbi
    University of Tubingen, Center for Medical Research, Tubingen, Germany
    Physiology (Bethesda) 23:64-74. 2008
    ..relationship between immune status, response to vaccination, health, and longevity, suggesting that the immune system becomes less effective with advancing age and that this is clinically relevant...
  82. doi Gimme shelter: the immune system during pregnancy
    Alba Muñoz-Suano
    Laboratory of Molecular Biology, Medical Research Council, Cambridge, UK
    Immunol Rev 241:20-38. 2011
    ..This alloreactivity turns placental viviparity into a major immunological challenge. The maternal immune system has to balance the opposing needs of maintaining robust immune reactivity to protect both mother and fetus ..
  83. ncbi Melatonin-immune system relationships
    Juan M Guerrero
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Spain
    Curr Top Med Chem 2:167-79. 2002
    ..the historical milestones that first highlighted the existence of a relationship between melatonin and the immune system and we summarize data from experiments which correlate the rhythmic production of melatonin with the rhythmic ..
  84. doi Functions of notch signaling in the immune system: consensus and controversies
    Julie S Yuan
    Hospital for Sick Children Research Institute, Department of Immunology, University of Toronto, Ontario, Canada
    Annu Rev Immunol 28:343-65. 2010
    ..Here we review recent advances in general aspects of Notch signaling, as well as studies probing Notch functions in these immunological processes...
  85. ncbi What brought the adaptive immune system to vertebrates?--The jaw hypothesis and the seahorse
    T Matsunaga
    Department of Immunology, University of Umea, Sweden
    Immunol Rev 166:177-86. 1998
    A hypothesis is discussed that the adaptive immune system of vertebrates evolved in the gastrointestinal regions of primitive jawed fish (placoderms) due to increased localized injuries and infections which were inadvertently brought ..
  86. pmc Requirement of bic/microRNA-155 for normal immune function
    Antony Rodriguez
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 316:608-11. 2007
    ..Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.
  87. pmc Effect of the novel influenza A (H1N1) virus in the human immune system
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, Greece, Athens, Greece
    PLoS ONE 4:e8393. 2009
    The pandemic by the novel H1N1 virus has created the need to study any probable effects of that infection in the immune system of the host.
  88. doi Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?
    Nathan Guéguinou
    Development and Immunogenetics Team, Nancy University, Faculte de Medecine, 5400 Vandoeuvre lès Nancy, JE 2537, France
    J Leukoc Biol 86:1027-38. 2009
    ..Weakening of the immune system associated with spaceflight is therefore an area that should be considered more thoroughly before we undertake ..
  89. doi Effects of triterpenes on the immune system
    Jose Luis Rios
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n 46100 Burjassot, Valencia, Spain
    J Ethnopharmacol 128:1-14. 2010
    ..and pharmacological effects of many medicinal plants used in folk medicine against diseases in which the immune system is implicated...
  90. pmc The many roles of TOX in the immune system
    Parinaz Aliahmad
    Research Division of Immunology, Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Curr Opin Immunol 24:173-7. 2012
    ..Although the exact molecular mechanism of action of TOX remains to be elucidated, the role of TOX in establishment of gene programs in the thymus and the potential of TOX as a regulator of E protein activity are discussed...
  91. doi The immune system in the aging human
    Paulina Dominika Rymkiewicz
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, 8A Biomedical Grove, 03 Immunos, Biopolis, Singapore
    Immunol Res 53:235-50. 2012
    ..The robustness of the immune system to eliminate or control infections is often eroded with advancing age...
  92. doi The immune system: role in hypertension
    Ernesto L Schiffrin
    Lady Davis Institute for Medical Research and Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Can J Cardiol 29:543-8. 2013
    ..T regulatory cells protect from blood pressure elevation acting on similar targets. These novel findings may open the way for new therapeutic approaches to improve outcomes in hypertension and cardiovascular disease in humans...
  93. pmc Identification of transcriptional regulators in the mouse immune system
    Vladimir Jojic
    Computer Science Department, Stanford University, Stanford, California, USA
    Nat Immunol 14:633-43. 2013
    The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood...
  94. pmc The human malaria parasite Pfs47 gene mediates evasion of the mosquito immune system
    Alvaro Molina-Cruz
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA
    Science 340:984-7. 2013
    ..falciparum gene that allows the parasite to infect A. gambiae without activating the mosquito immune system. Disruption of Pfs47 greatly reduced parasite survival in the mosquito, and this phenotype could be reverted ..
  95. doi Crosstalk between the circadian clock circuitry and the immune system
    Nicolas Cermakian
    Laboratory of Molecular Chronobiology, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Chronobiol Int 30:870-88. 2013
    Various features, components, and functions of the immune system present daily variations. Immunocompetent cell counts and cytokine levels present variations according to the time of day and the sleep-wake cycle...
  96. ncbi CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system
    S Levy
    Department of Medicine, Stanford University Medical Center, California 94305, USA
    Annu Rev Immunol 16:89-109. 1998
    ..Like CD81, several tetraspanins are involved in cell adhesion, motility, and metastasis, as well as cell activation and signal transduction...
  97. doi Adenosine: an endogenous modulator of innate immune system with therapeutic potential
    Vijay Kumar
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    Eur J Pharmacol 616:7-15. 2009
    ....
  98. doi Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system
    Femke Baeke
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven KUL, Herestraat 49, O and N1, bus 902, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 121:221-7. 2010
    ..Within the immune system, dendritic cells represent key targets for this hormone and 1,25(OH)2D3-induced changes in their phenotype and ..
  99. doi The role of glia and the immune system in the development and maintenance of neuropathic pain
    Ricardo Vallejo
    Millennium Pain Center, Bloomington, Illinois 61701, USA
    Pain Pract 10:167-84. 2010
    ..Recent studies indicate a communication between the immune system and the nervous system...
  100. pmc Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system
    Nicolas Rapin
    Biotech Research and Innovation Centre and Bioinformatics Centre, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e9862. 2010
    We present a new approach to the study of the immune system that combines techniques of systems biology with information provided by data-driven prediction methods...
  101. doi MicroRNA in the adaptive immune system, in sickness and in health
    Adrian Liston
    VIB and University of Leuven, Leuven, 3000, Belgium
    J Clin Immunol 30:339-46. 2010
    ..These 19-24 nucleotide regulatory RNA molecules have essential roles in multiple faucets of adaptive immunity, from regulating the development of the key cellular players to the activation and function in immune responses...

Research Grants72

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..It is associated with immune system disorders like rheumatoid arthritis. It can cause blindness in severe cases...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..It is associated with immune system disorders like rheumatoid arthritis. It can cause blindness in severe cases...
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..chronically infects one third of the worlds'population and similarly must avoid clearance by the host immune system. However, there is currently little understanding of whether M...
  5. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  6. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..and viral, alcoholic and autoimmune hepatitis and even the hepatic stage of malaria, especially if a human immune system were reconstituted in addition to the liver...
  7. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..A biomarker study [The Corn Farmer Study], nested within the AHS is assessing perturbations in the immune system of a group of Iowa corn farmers and a control group not exposed to corn farming, during a calendar year, some ..
  8. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..A biomarker study [The Corn Farmer Study], nested within the AHS is assessing perturbations in the immune system of a group of Iowa corn farmers and a control group not exposed to corn farming, during a calendar year, some ..
  9. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    ..Our work is applicable to other cell types, particularly other cells of the immune system. Results of these analyses will contribute important new insight into the nature and assembly of membrane ..
  10. Carole R Mendelson; Fiscal Year: 2016
    ..After birth, SP-A serves as an important component of the innate immune system within the lung to protect against invading microorganisms and to modulate inflammation...
  11. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..from psoriatic arthritis has increased level of NGF and whether NGF is damaging the joint by altering the immune system. To determine these goals we are studying blood, joint fluid and joint tissues from patients with psoriatic ..
  12. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..studies in monkeys suggest that it is unlikely that vaccine approaches that stimulate a single arm of the immune system will provide effective protection from viral infection...
  13. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..error at the point of testing introduces extremely high false negative rates for direct PCR and that the host immune system has little opportunity to develop antibodies against this bacteria...
  14. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..endocannabinoid system (ECS) is a natural system that plays an important role in the regulation of the CNS and immune system. Ajulemic acid (AJA), a non-psychotropic endocannabinoid mimetic has been shown to be highly effective in ..
  15. Craig T Morita; Fiscal Year: 2016
    ..effectiveness of these therapies provides evidence that it is possible to treat malignancies by activating the immune system with bacteria...
  16. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The Ets transcription factor Fli1 clearly has effects on the immune system and the pathogenesis of lupus as evidenced by the immune phenotype of Fli1 transgenic mice and the profound effect of Fli1 ..
  17. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..entails characterization of the donor's white blood cells in the recipient, how the recipient's immune system responds toward the modified transplants, and the extent to which the transplant remains viable in recipient ..
  18. Mitchell Kronenberg; Fiscal Year: 2014
    ..RELEVANCE: The immune system prevents infections, but can also create autoimmune or inflammatory diseases such as type I diabetes and ..
  19. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..imaging technique to measure nanoparticle mediated cytoskeletal dysfunction and damage (toxicity) on immune system cells...
  20. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..The findings would shed light on the role of immune system in health and disease and may identify new therapeutic approaches for arthritis.
  21. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..Diseases of long term Ca2+ signals, which show striking parallels in muscle and the immune system, include SCID, a familial immune defect that combines loss of SOCE in lymphocytes and a myogenic myopathy...
  22. Trichothecene Toxicity and the Ribotoxic Stress Response
    James J Pestka; Fiscal Year: 2012
    ..as food contaminants worldwide, have been etiologically linked to human and animal illnesses with the immune system being a major target...
  23. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..host will improve current understanding of the GAS strategies to avoid killing by phagocytic cells of the immune system, and may uncover target molecules and/or pathways for the development of new antibacterial targets or a GAS ..
  24. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    ..Aim2. To develop a pig hosting a human immune system. Aim 2a...
  25. Charlotte Cunningham-Rundles; Fiscal Year: 2015
    ..RELEVANCE (See instructions): Defects of the humoral immune system lead to infectious diseases, an inability to be vaccinated, immune dysregulation and autoimmune disease...
  26. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..and severity in the murine CIA mode of RA due to activation of the SNS which results in priming of the immune system to CII...
  27. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..There is growing awareness of the vital role played by the innate immune system in IRI...
  28. DANIEL J CARR; Fiscal Year: 2015
    ..Resistance to infection includes the innate immune system. Central to the innate immune response to virus infection is the type I interferon (IFN) pathway which upon ..
  29. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..by applicant): Autoimmune diseases, a constellation of chronic, disabling illnesses that result from the immune system attacking the body's own tissues, are estimated to adversely affect up to 25 million persons in the U.S...
  30. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    Viral infections caused by Herpes Simplex virus-1 (HSV-1), often occur as a result of a compromised immune system. The innate immune system is the first line of defense against prevention of these pathogens and consists of numerous ..
  31. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..specialized antigen-presenting cells (APCs) mediate innate immunity, subsequent activation of the adaptive immune system and in the development of immune tolerance...
  32. Cornelia M Weyand; Fiscal Year: 2016
    ..Our studies have led to the discovery that patients with RA have premature aging of the immune system. Remodeling of the T cell pool, characterized by shrinkage of T cell diversity and accumulation of end-..
  33. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mucosal immune system plays a central role in preventing the transmission of HIV-1 by a combination of rapid, non-specific responses mediated by innate immune cells, as well as by the induction of ..
  34. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..Although genetic susceptibility, such as the MHC, play an important role in type 1 diabetes, an immune system-mediated disease, the disease process is significantly shaped by environmental factors as a) there is a ..
  35. Non-coding RNA engineers antibody diversity
    Uttiya Basu; Fiscal Year: 2011
    ..produced from B-lymphocytes that are present in the bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign antigens, such as bacteria and viruses...
  36. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..These adjuvants have been shown in animal models to augment targeting of vaccine antigens to the immune system while safely eliciting potent humoral and Th1-type cellular immune responses without inducing inflammation...
  37. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..More recently, we have shown that the adaptive immune system and the cytokine IL-17 are important in the genesis of hypertension...
  38. Knockdown of Gene Expression in Immune Cells in Humanized Mice
    Judy Lieberman; Fiscal Year: 2010
    ..BLT mice reconstitute an immune system that mimics human immune cell distribution in uninfected mice, as well as viral dynamics and B and T cell ..
  39. Tatiana Efimova; Fiscal Year: 2014
    ..given the global nature of p384 ablation, p384 may act non cell autonomously, for instance, in the innate immune system, known for its promoting role in skin carcinogenesis...
  40. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ..Public Health Relevance: Signal transmission within cells of the immune system coordinates the host defense against microbial pathogens and must be tightly regulated to avoid chronic ..
  41. Betty L Slagle; Fiscal Year: 2014
    ..in mediating carcinogenesis is complex and includes integration of viral DNA into host chromosomes, the host immune system, and expression of the viral regulatory HBx protein...
  42. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    ..Also swine metabolize retinol comparable to humans. Thus the effects of vitamin A on the porcine immune system most closely mimic that in humans, and piglets best mirror responses of infants to rotavirus diarrhea and ..
  43. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Quentin J Baca; Fiscal Year: 2010
    ..mechanisms of membrane receptor mobility regulation and how they relate to T cell activation in the human immune system. Specifically, we will examine the mobility control mechanisms and molecular associations of the receptor-like ..
  44. Ameae M Walker; Fiscal Year: 2015
    ..time points, it seems unlikely that the transferred cells became long-lived components of the recipient's immune system, but rather that information was transferred from dam to pup...
  45. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ..are distributed throughout many organ systems and have established roles in the regulation of bone health, the immune system, growth, differentiation and development...
  46. Christin Carter-Su; Fiscal Year: 2016
    ..growth and metabolism, and other SH2B1 activating ligands contribute to, prevent and/or alleviate symptoms of a variety of diseases including obesity, various cancers, diabetes, multiple sclerosis, and diseases of the immune system.
  47. Sienmi Du; Fiscal Year: 2014
    ..Irradiation bone marrow chimera is a widely used tool in basic immunology to manipulate the immune system independently from other tissues...
  48. Claire Larmonier; Fiscal Year: 2014
    ..role of Parp1 in colitis is restricted to either colonic epithelial cells or other cells of the innate immune system. A novel mouse model for conditional cell-type specific Parp1 targeting, Parp1/Rag1 double knockout mice, and ..
  49. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..In this application, we will study the role of a subset of cells in the immune system called T helper cells to determine if they could be responsible for the destruction of lung in subjects with ..
  50. KATHERINE YUDEH KING; Fiscal Year: 2014
    ..The significance of these studies is that they will elucidate the mechanisms by which the immune system triggers replenishment of the pool of peripheral immune cells during infection...
  51. Jakub Tolar; Fiscal Year: 2016
    ..and the fact that genetically corrected iPSC-derived keratinocytes would not be rejected by the patient's immune system, since EBS is a dominant form of EB, we believe that EBS is an ideal model for generating "proof of concept" ..
  52. MOLECULAR BIOLOGY OF HEMORRHAGIC SHOCK
    Timothy R Billiar; Fiscal Year: 2013
    ..the proximal steps have provided compelling evidence that pattern recognition receptors (PRR) of the innate immune system (Toll-like receptors) are engaged early following injury and both initiate and drive the inflammatory response...
  53. Richard J Samulski; Fiscal Year: 2014
    ..antigen presentation will be attenuated only in AAV2 transduced cells without systemic side effects on the immune system (as would be the case with immunosuppressive drugs or application of regulator T cells)...
  54. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Engineering the Brain Immune System for Tumor Therapy Abstract Brain glioblastoma multiforme (GBM) kills through glioma cells that infiltrate normal surrounding brain, with consequent displacement ..
  55. James E Gern; Fiscal Year: 2016
    ..of allergen sensitization and highest vulnerability to VRIs coincides with the maturation phase of the immune system, and there is evidence that farm exposures enhance development of innate immunity and T regulatory (Treg) cell ..
  56. Fic-mediated Adenylylation
    CAROLYN ANN WORBY; Fiscal Year: 2013
    ..type III effector protein, YopT, one of several virulence factors used by Yersinia to compromise the host immune system. We previously demonstrated that Yersinia YopT functions as a cysteine protease that cleaves and inactivates ..
  57. Amy Johnson; Fiscal Year: 2015
    ..linked obesity and inflammation;pro-inflammatory, classically activated M1 macrophage cells of the innate immune system infiltrate adipose tissue at the onset of weight gain contributing to the inflammatory state of fat, ..
  58. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    ..unknown, though toll-like receptors (TLR) which are pattern recognition receptors involved in the innate immune system are a likely candidate...
  59. Identifying underlying mechanisms of intracellular changes in response to caregiv
    MELANIE SARAH FLINT; Fiscal Year: 2013
    ..is to determine how deregulation of cytoskeletal proteins in T cells (the major mediators of the adaptive immune system) correlate with psycho behavioral responses over time assessed in the parent grant thus negatively impacting ..
  60. Localization and characterization of the Clostridium difficile biofilm
    Adam Driks; Fiscal Year: 2013
    ..critical host-defense molecules such as antimicrobial peptides and antibodies, and avoid recognition by the immune system. A C...
  61. Scott R Barnum; Fiscal Year: 2014
    ..The complement system, a major arm of the innate immune system, drives neuroinflammation along with other inflammatory mediators in most, if not all, central nervous system ..
  62. Characterization of IL36, a novel cytokine
    Albert Zlotnik; Fiscal Year: 2012
    ..Given that many human genes remain uncharacterized, we sought to identify novel genes associated with the immune system through a systematic analysis of the BIGE database...
  63. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2005
    ..In theory, the immune system usually reacts against an invading organism such as an insect bite or bacterial infection, or is over-..
  64. ApoVax-SVN as a Novel Vaccine for Cancer Immunotherapy
    Haval Shirwan; Fiscal Year: 2007
    ..potential remains to be realized partially due to the complex nature of interactions taking place between the immune system and cancer cells in the course of tumor progression...
  65. Effects of Probiotic Lactobacilli on Rotavirus Immunity
    Lijuan Yuan; Fiscal Year: 2006
    ..of the human intestine with commensal microbes is hypothesized to drive the maturation of the mucosal immune system during neonatal life, but the mechanisms are unknown...
  66. Analysis of Human B Cell Tolerance in Humanized Mice
    Roberta Pelanda; Fiscal Year: 2009
    ..of the process of B cell tolerance and B cell selection in humans originates from studies of the mouse immune system and, in particular, of the immune system of immunoglobulin transgenic mice, because in these systems we can ..
  67. Opioid-Mediated Fas Expression in Lymphocyte Apoptosis
    Yufang Shi; Fiscal Year: 2005
    Space flight has profound effects on the immune system of humans, monkeys and rodents...