fetal blood

Summary

Summary: Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.

Top Publications

  1. ncbi Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro
    Ross N La Motte-Mohs
    Department of Immunology, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
    Blood 105:1431-9. 2005
  2. ncbi Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells
    Geneve Awong
    Department of Immunology, University of Toronto, Toronto, ON, Canada
    Blood 114:972-82. 2009
  3. ncbi Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    Susanne Kern
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Mannheim, Germany
    Stem Cells 24:1294-301. 2006
  4. ncbi Mesenchymal progenitor cells in human umbilical cord blood
    A Erices
    Unidad de Biologia Celular, INTA, Universidad de Chile, Santiago, Chile
    Br J Haematol 109:235-42. 2000
  5. ncbi Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 104:2752-60. 2004
  6. ncbi Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow
    C Campagnoli
    Department of Maternal and Fetal Medicine, Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, London, United Kingdom
    Blood 98:2396-402. 2001
  7. ncbi Isolation of multipotent mesenchymal stem cells from umbilical cord blood
    Oscar K Lee
    Department of Orthopaedics and Traumatology, Veterans General Hospital Taipei, Taipei 11221, Taiwan
    Blood 103:1669-75. 2004
  8. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
  9. ncbi Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats
    J Chen
    Departments of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    Stroke 32:2682-8. 2001
  10. ncbi Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood: preliminary report
    M Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 21:297-303. 2007

Detail Information

Publications267 found, 100 shown here

  1. ncbi Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro
    Ross N La Motte-Mohs
    Department of Immunology, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
    Blood 105:1431-9. 2005
    ..These results establish an efficient in vitro coculture system for the generation of T cells from human HSCs, providing a new avenue for the study of early T-cell differentiation and function...
  2. ncbi Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells
    Geneve Awong
    Department of Immunology, University of Toronto, Toronto, ON, Canada
    Blood 114:972-82. 2009
    ..Taken together, the identification of T-progenitor subsets readily generated in vitro may offer important avenues to improve cellular-based immune-reconstitution approaches...
  3. ncbi Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    Susanne Kern
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Mannheim, Germany
    Stem Cells 24:1294-301. 2006
    ..Both UCB and AT are attractive alternatives to BM in isolating MSC: AT as it contains MSCs at the highest frequency and UCB as it seems to be expandable to higher numbers...
  4. ncbi Mesenchymal progenitor cells in human umbilical cord blood
    A Erices
    Unidad de Biologia Celular, INTA, Universidad de Chile, Santiago, Chile
    Br J Haematol 109:235-42. 2000
    ..Our results suggest that preterm, as compared with term, cord blood is richer in mesenchymal progenitors, similar to haematopoietic progenitors...
  5. ncbi Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 104:2752-60. 2004
    ....
  6. ncbi Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow
    C Campagnoli
    Department of Maternal and Fetal Medicine, Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, London, United Kingdom
    Blood 98:2396-402. 2001
    ..MSCs were isolated and characterized in first-trimester fetal blood, liver, and bone marrow...
  7. ncbi Isolation of multipotent mesenchymal stem cells from umbilical cord blood
    Oscar K Lee
    Department of Orthopaedics and Traumatology, Veterans General Hospital Taipei, Taipei 11221, Taiwan
    Blood 103:1669-75. 2004
    ..In conclusion, umbilical cord blood does contain mesenchymal stem cells and should not be regarded as medical waste. It can serve as an alternative source of mesenchymal stem cells to bone marrow...
  8. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  9. ncbi Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats
    J Chen
    Departments of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    Stroke 32:2682-8. 2001
    ..01) compared with normal brain tissue. CONCLUSIONS: Intravenously administered HUCBC enter brain, survive, migrate, and improve functional recovery after stroke. HUCBC transplantation may provide a cell source to treat stroke...
  10. ncbi Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood: preliminary report
    M Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 21:297-303. 2007
    ..Further studies are needed to see if human CB-isolated VSELs similar to their murine BM-derived counterparts are endowed with pluripotent stem cell properties...
  11. ncbi Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice
    Willy A Noort
    Department of Hematology, Leiden University Medical Center, Leiden University Medical Center, The Netherlands
    Exp Hematol 30:870-8. 2002
    ..In cotransplantation experiments, we examined the homing of MSC as well as the effect on engraftment of human umbilical cord blood (UCB)-derived CD34(+) cells in NOD/SCID mice...
  12. ncbi Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848
    Ofer Levy
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 173:4627-34. 2004
    ..Conversely, relative preservation of responses to R-848 may present unique opportunities for augmenting innate and acquired immunity in the human newborn...
  13. pmc Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization
    T Murohara
    The Cardiovascular Research Institute, Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    J Clin Invest 105:1527-36. 2000
    ..In conclusion, umbilical cord blood is a valuable source of EPCs, and transplantation of cord blood-derived EPCs represents a promising strategy for modulating postnatal neovascularization...
  14. ncbi Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors
    M J Laughlin
    Department of Medicine, Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, OH 44106 5065, USA
    N Engl J Med 344:1815-22. 2001
    ..We studied the use of transplantation of umbilical-cord blood to restore hematopoiesis in adults...
  15. pmc Influence of prenatal lead exposure on genomic methylation of cord blood DNA
    J Richard Pilsner
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Environ Health Perspect 117:1466-71. 2009
    ..Epigenetic fetal programming via DNA methylation may provide a pathway by which environmental lead exposure can influence disease susceptibility...
  16. ncbi Malaria elicits type 1 cytokines in the human placenta: IFN-gamma and TNF-alpha associated with pregnancy outcomes
    M Fried
    U S Army Medical Research Unit, Kenya Medical Research Institute, Kisumu
    J Immunol 160:2523-30. 1998
    ..This is the first demonstration that these placental cytokine changes are associated with poor pregnancy outcomes in humans...
  17. ncbi Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival
    John E Wagner
    Blood and Marrow Transplant Program of the Department of Pediatrics, University of Minnesota Cancer Center and School of Medicine, Minneapolis 55455, USA
    Blood 100:1611-8. 2002
    ..7 x 10(5) CD34(+) cells per kilogram of recipient's body weight. Therefore, graft selection should be based principally on CD34 cell dose when multiple UCB units exist with an HLA disparity of 2 or less...
  18. pmc Relation between cord blood mercury levels and early child development in a World Trade Center cohort
    Sally Ann Lederman
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 116:1085-91. 2008
    ..This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development...
  19. ncbi The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA
    Cell Transplant 20:85-94. 2011
    ..Evidence of anti-inflammatory effects and secretion of specific cytokines and growth factors that promote cell survival, rather than cell replacement, have been detected in both transplanted cells...
  20. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
    ..Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform...
  21. ncbi Transplantation of ex-vivo culture-expanded parental haploidentical mesenchymal stem cells to promote engraftment in pediatric recipients of unrelated donor umbilical cord blood: results of a phase I-II clinical trial
    M L MacMillan
    Division of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 43:447-54. 2009
    ..This encouraging safety profile with haploidentical MSCs supports the investigation of unrelated 'off the shelf' allogeneic HLA-mismatched MSC products...
  22. ncbi Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue
    C K Rebelatto
    Laboratorio Experimental de Cultivo Celular, Pontificia Universidade Catolica do Parana, Rua Imaculada Conceição 1155, Curitiba 80215 901, Brazil
    Exp Biol Med (Maywood) 233:901-13. 2008
    ..Therefore, it may be crucial to predetermine the most appropriate MSC source for future clinical applications...
  23. ncbi Multipotent stem cells from umbilical cord: cord is richer than blood!
    Mariane Secco
    Human Genome Research Center, Department of Genetic and Evolutive Biology, University of Sao Paulo, Rua do Matao, n 106, Cidade Universitaria, Sao Paulo, SP, CEP 05508 090, Brazil
    Stem Cells 26:146-50. 2008
    ....
  24. pmc Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution
    Colleen Delaney
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Med 16:232-6. 2010
    ..To our knowledge, this is the first instance of rapid engraftment derived from ex vivo expanded stem/progenitor cells in humans...
  25. ncbi Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling
    Kambis Sadeghi
    Department of Pediatrics, Division of Neonatology, Inborn Errors and Intensive Care, Medical University of Vienna, A 1090 Vienna, Austria
    J Infect Dis 195:296-302. 2007
    ..The reduced functional response to bacterial cell wall components appears to be part of the functional immaturity of the neonatal immune system and might predispose premature newborns to bacterial infection...
  26. ncbi Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood
    Karen Bieback
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Friedrich Ebert Strasse 107, D 68167 Mannheim
    Stem Cells 22:625-34. 2004
    ..Because MSC-like cells can be isolated at high efficacy from full-term UCB donations, we regard UCB as an additional stem cell source for experimental and potentially clinical purposes...
  27. pmc Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics
    Ralitza Danova-Alt
    Vita 34 AG, Leipzig, Germany
    PLoS ONE 7:e34899. 2012
    ..These data support neither an embryonic nor an adult stem cell like phenotype, suggesting rather that hUCB VSEL cells are an aberrant and inactive population that is not comparable to murine VSEL cells...
  28. ncbi Immunological and regenerative properties of cord blood stem cells
    Roberto Francese
    Dipartimento di Medicina ed Oncologia Sperimentale, Universita degli Studi di Torino, Italy Sorgente Research, Milano, Italy
    Clin Immunol 136:309-22. 2010
    ..g., type 1 diabetes). Our review will demonstrate how CB-SCs could become a powerful tool not only for regenerative medicine but for autoimmune and inflammatory diseases as well...
  29. pmc Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells
    Kejin Hu
    Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, WI 53715, USA
    Blood 117:e109-19. 2011
    ..This approach provides an opportunity to explore banked normal and diseased CB and BM samples without the limitations associated with virus-based methods...
  30. pmc Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life
    M E Belderbos
    Wilhelmina Children s Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands
    Clin Immunol 133:228-37. 2009
    ..Polarization in neonatal cytokine responses to LPS could contribute to neonatal susceptibility to severe bacterial infection...
  31. ncbi Organochlorine and heavy metals in newborns: results from the Flemish Environment and Health Survey (FLEHS 2002-2006)
    Gudrun Koppen
    Environmental Risk and Health, Toxicology Group, Flemish Institute of Technological Research, 2400 Mol, Belgium
    Environ Int 35:1015-22. 2009
    ..It was concluded that the place of birth in Flanders is an important determinant of the load of pollutants measured at the start of life. This underlines the validity of human biomonitoring on (relatively) small geographical scale...
  32. ncbi Beneficial effects of a polyunsaturated fatty acid on infant development: evidence from the inuit of arctic Quebec
    Joseph L Jacobson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Pediatr 152:356-64. 2008
    ....
  33. pmc Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice
    William V Nikolic
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    Stem Cells Dev 17:423-39. 2008
    ..Increased microglial phagocytic activity in this scenario was inhibited by addition of recombinant CD40L protein. These data suggest that HUCBC infusion mitigates AD-like pathology by disrupting CD40L activity...
  34. ncbi Ex vivo expansion of umbilical cord blood for transplantation
    S S Tung
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Best Pract Res Clin Haematol 23:245-57. 2010
    ..CB ex vivo expansion holds the promise of delivering higher cell doses and improved outcomes. Here we discuss different methods of expansion, their shortcomings and future directions...
  35. ncbi Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim
    H Nagayama
    Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 29:197-204. 2002
    ..Immunological examination after autologous hematopoietic recovery revealed an almost normal T cell count. However, immune functions were severely impaired. The patient died from infectious complication 210 days after the accident...
  36. pmc Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels
    Patrick Au
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Blood 111:1302-5. 2008
    ..Thus, umbilical cord blood EPCs hold great therapeutic potential, and their use should be pursued for vascular engineering...
  37. pmc Role of MyD88 in diminished tumor necrosis factor alpha production by newborn mononuclear cells in response to lipopolysaccharide
    Sen Rong Yan
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia B3J 3G9, Canada
    Infect Immun 72:1223-9. 2004
    ..Since TLR-4 signals intracellularly through the adapter protein, MyD88, we hypothesize that MyD88-dependent factors are responsible for delayed and decreased TNF-alpha secretion in newborn monocytes...
  38. pmc Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus
    Ute M Schaefer-Graf
    Department of Obstetrics, Vivantes Medical Center Berlin Neukoelln, Berlin, Germany
    Diabetes Care 31:1858-63. 2008
    ..To determine the contribution of maternal glucose and lipids to intrauterine metabolic environment and fetal growth in pregnancies with gestational diabetes mellitus (GDM)...
  39. ncbi Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction
    V A Rodie
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary University NHS Trust, Glasgow G31 2ER, UK
    Atherosclerosis 176:181-7. 2004
    ..Our findings are potentially pertinent to understanding the future cardiovascular health of the offspring...
  40. ncbi Mesenchymal stem/progenitor cells developed in cultures from UC blood
    S E Yang
    Department of Research and Development for Cellular Therapy, Medipost Biomedical Research Institute, Yongin, Korea
    Cytotherapy 6:476-86. 2004
    ..Our results may encourage the use of UCB as an attractive target for allogeneic cellular therapeutic options in tissue engineering...
  41. pmc Acquisition of adult-like TLR4 and TLR9 responses during the first year of life
    Muriel Nguyen
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    PLoS ONE 5:e10407. 2010
    ..Herein, we analyzed the evolution of these responses within the first year of life...
  42. pmc High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy
    Jan Spanholtz
    Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 5:e9221. 2010
    ..Our culture system exemplifies a major breakthrough in producing pure NK cell products from limited numbers of CD34(+) cells for cancer immunotherapy...
  43. ncbi Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy
    Juliet N Barker
    Blood and Marrow Transplant Program, Division of Medical and Pediatric Oncology, University of Minnesota, Box 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 105:1343-7. 2005
    ..Therefore, transplantation of 2 partially HLA-matched UCB units is safe, and may overcome the cell-dose barrier that limits the use of UCB in many adults and adolescents...
  44. pmc Placental tumor necrosis factor alpha but not gamma interferon is associated with placental malaria and low birth weight in Malawian women
    Stephen J Rogerson
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Department of Obstetrics and Gynaecology, College of Medicine, University of Malawi, Blantyre, Malawi
    Infect Immun 71:267-70. 2003
    ..Placental production of TNF-alpha, but not of IFN-gamma, may be implicated in impaired fetal growth in Malawian women...
  45. ncbi Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice
    Takashi Yahata
    Research Center for Cell Transplantation, Kanagawa, Japan
    J Immunol 169:204-9. 2002
    ..This newly developed mouse model is expected to become a useful tool for the analysis of human T lymphopoiesis and immune response, and an animal model for studying T lymphotropic viral infections, such as HIV...
  46. pmc Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells
    Yong Zhao
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 West Polk Street, Chicago, IL 60612, USA
    BMC Med 10:3. 2012
    ....
  47. ncbi Maternal vitamin D predominates over genetic factors in determining neonatal circulating vitamin D concentrations
    Boris Novakovic
    Cancer and Disease Epigenetics Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Australia
    Am J Clin Nutr 96:188-95. 2012
    ..There are multiple potential regulators of neonatal vitamin D status of environmental, genetic, and epigenetic origins. The relation between these factors and circulating neonatal vitamin D has yet to be fully characterized...
  48. ncbi Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women
    Iman Al-Saleh
    Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Int J Hyg Environ Health 214:79-101. 2011
    ..Preventive measures to eliminate or minimize the unnecessary risk of fetus exposure to heavy metals or other pollutants during pregnancy should be initiated once these factors are identified...
  49. ncbi The stress of birth enhances in vitro spontaneous and IL-8-induced neutrophil chemotaxis in the human newborn
    Elham Yektaei-Karin
    Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Pediatr Allergy Immunol 18:643-51. 2007
    ..Assisted delivery may trigger excessive recruitment of additional inflammatory cells and IFN-gamma release...
  50. ncbi Neonatal vitamin D status at birth at latitude 32 degrees 72': evidence of deficiency
    L A Basile
    Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Perinatol 27:568-71. 2007
    ..With vitamin D deficiency as a serious public health problem, vitamin D status at birth was measured in neonates at latitude 32 degrees 72' (southeastern United States)...
  51. ncbi Interferon regulatory factor 7-mediated responses are defective in cord blood plasmacytoid dendritic cells
    Benedicte Danis
    Institute for Medical Immunology IMI, Universite Libre de Bruxelles ULB, Charleroi, Belgium
    Eur J Immunol 38:507-17. 2008
    ..Our data provide a molecular understanding for the decreased ability of cord blood pDC to produce type I IFN upon viral stimulation...
  52. ncbi Paracrine effect of canine allogenic umbilical cord blood-derived mesenchymal stromal cells mixed with beta-tricalcium phosphate on bone regeneration in ectopic implantations
    Ye Eun Byeon
    Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Cytotherapy 12:626-36. 2010
    ..The aim of this study was to evaluate the paracrine effects of canine umbilical cord blood (cUCB) mesenchymal stromal cells (MSC) mixed with beta-tricalcium phosphate (beta-TCP) on bone regeneration in ectopic implantation...
  53. ncbi Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: results from the Duisburg cohort study
    Yuguang Cao
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int J Hyg Environ Health 211:30-9. 2008
    ..This study was done to evaluate effects related to the HPG axis...
  54. pmc The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn
    Ofer Levy
    Infectious Diseases, Children s Hospital, Boston, MA 02115, USA
    J Immunol 177:1956-66. 2006
    ..We conclude that the distinct adenosine system of newborns polarizes TLR-mediated cytokine production during the perinatal period and may thereby modulate their innate and adaptive immune responses...
  55. pmc Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice
    Yong Zhao
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e4226. 2009
    ..Regulatory T cells (Tregs) play a pivotal role in maintaining self-tolerance through their inhibitory impact on autoreactive effector T cells. An abnormality of Tregs is associated with initiation of progression of T1D...
  56. ncbi Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples
    Rocio Monroy
    Department of Obstetrics and Gynecology, McMaster University, HSC 3N52D, 1200 Main Street West, Hamilton, Ontario, Canada
    Environ Res 108:56-62. 2008
    ..Taken together our data demonstrate that although there is widespread exposure to PFCs during development, these exposures do not affect birth weight...
  57. pmc Efficient reprogramming of human cord blood CD34+ cells into induced pluripotent stem cells with OCT4 and SOX2 alone
    Xianmei Meng
    Division of Regenerative Medicine MC1528B, Department of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Mol Ther 20:408-16. 2012
    ..This report is the first to describe the generation of transgene-free iPSCs with the use of OCT4 and SOX2 alone. These findings have important implications for the clinical applications of iPSCs...
  58. pmc Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan
    Wei Chun Chou
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    Environ Health 10:94. 2011
    ....
  59. pmc Hematopoietic differentiation of umbilical cord blood-derived very small embryonic/epiblast-like stem cells
    J Ratajczak
    Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 25:1278-85. 2011
    ..Overall, our data suggest that UCB-VSELs correspond to the most primitive population of HSPCs in UCB...
  60. pmc T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells
    Magda De Smedt
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, 4Blok A, De Pintelaan 185, 9000 Ghent, Belgium
    Haematologica 96:646-54. 2011
    ..This study focuses on the comparison of the capacity of cord blood and bone marrow hematopoietic stem cells to generate T cells in vitro...
  61. ncbi BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells
    Aleksandra Rizo
    Department of Hematology, University Medical Center Groningen, Groningen, The Netherland
    Blood 116:4621-30. 2010
    ..Retroviral introduction of BMI1 in primary chronic-phase CD34(+) cells from CML patients elevated their proliferative capacity and self-renewal properties. Thus, our data identify BMI1 as a potential therapeutic target in CML...
  62. pmc Sensitivity of continuous performance test (CPT) at age 14 years to developmental methylmercury exposure
    Jordi Julvez
    Harvard School of Public Health, Boston, MA, USA
    Neurotoxicol Teratol 32:627-32. 2010
    ..When using CPT data as a possible measure of neurotoxicity, test results should therefore be analyzed in regard to time from test initiation and not as overall average reaction times...
  63. ncbi Neonatal blood glucose concentrations in caesarean and vaginally delivered term infants
    Ronella Marom
    Department of Neonatology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Israel
    Acta Paediatr 99:1474-7. 2010
    ..Little is known about the glucose concentrations at and after birth of infants delivered by caesarean section (CS), when compared with infants born vaginally (VD)...
  64. ncbi Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells
    Bianca Schaub
    Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU Munich, Munich, Germany
    J Allergy Clin Immunol 123:774-82.e5. 2009
    ..Cross-sectional studies suggest that maternal exposure to farming decreases the risk of allergic diseases in offspring. The potential underlying immunologic mechanisms are not understood...
  65. ncbi Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia
    Mary J Laughlin
    Case Comprehensive Cancer Center and University Hospitals of Cleveland Ireland Cancer Center, Cleveland, USA
    N Engl J Med 351:2265-75. 2004
    ..Data regarding the outcome of cord-blood transplantation in adults are scant, despite the fact that these grafts are increasingly used in adults...
  66. ncbi Phthalate exposure in pregnant women and their children in central Taiwan
    Susana Lin
    National Health Research Institutes, Taiwan
    Chemosphere 82:947-55. 2011
    ..The level of phthalate metabolites in milk and cord blood were comparable to those found in other populations. Further studies of health effects related to DEHP and DiNP exposure are necessary for the children...
  67. pmc Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo
    Alice B Salter
    Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Blood 113:2104-7. 2009
    ..These data demonstrate that allogeneic EPC infusions can augment hematopoiesis and suggest a relationship between BM microvascular recovery and hematopoietic reconstitution in vivo...
  68. ncbi Early detection of an early onset infection in the neonate based on measurements of procalcitonin and C-reactive protein concentrations in cord blood
    Agnieszka Kordek
    Pomeranian Medical University, Szczecin, Poland
    Clin Chem Lab Med 46:1143-8. 2008
    ....
  69. ncbi Differences in the implications of maternal lipids on fetal metabolism and growth between gestational diabetes mellitus and control pregnancies
    U M Schaefer-Graf
    Berlin Center for Diabetes in Pregnancy, Department of Obstetrics and Gynecology, St Joseph s Hospital, Berlin, Germany
    Diabet Med 28:1053-9. 2011
    ....
  70. ncbi Human maternal and umbilical cord blood concentrations of polybrominated diphenyl ethers
    Warren G Foster
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Chemosphere 84:1301-9. 2011
    ....
  71. ncbi Megakaryocytopoiesis and thrombopoiesis in hematopoietic stem cells exposed to ionizing radiation
    Satoru Monzen
    Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences, 66 1 Hon cho, Hirosaki, Aomori 036 8564, Japan
    Radiat Res 176:716-24. 2011
    ..Ionizing radiation may have the potential to promote both megakaryocytopoiesis and thrombopoiesis...
  72. ncbi First trimester embryo-fetoscopic and ultrasound-guided fetal blood sampling for ex vivo viral transduction of cultured human fetal mesenchymal stem cells
    Jerry Chan
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
    Hum Reprod 23:2427-37. 2008
    ..We investigated the feasibility of harvesting circulating first trimester human fetal mesenchymal stem cells (hfMSCs) for ex vivo gene therapy...
  73. ncbi Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Exp Hematol 33:1402-16. 2005
    ..Whereas surface antigen markers have failed to precisely define this population, microarray analysis might provide a better tool for characterization of MSC...
  74. pmc The relation of lead neurotoxicity to the event-related potential P3b component in Inuit children from arctic Québec
    Olivier Boucher
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Neurotoxicology 30:1070-7. 2009
    ..This study strengthens the arguments for reducing sources of Pb exposure in Nunavik and for lowering the blood Pb concentrations considered "acceptable" in governmental policies...
  75. ncbi Oxidative stress and antioxidant status in neonates born to pre-eclamptic mother
    Md Zakir H Howlader
    Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh
    J Trop Pediatr 55:363-7. 2009
    ..To observe the effect of pre-eclampsia on neonates, this study was designed to explore oxidative stress and anti-oxidant status in the fetal circulation in pre-eclampsia...
  76. pmc Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort
    Rosalind J Wright
    The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 182:25-33. 2010
    ..Stress-elicited disruption of immunity begins in utero...
  77. ncbi Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism
    Yu Show Fu
    155 Sec 2, Li Nung Street, 112, Department of Anatomy, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Stem Cells 24:115-24. 2006
    ..4 mm both rostrally and caudally. These results suggest that human umbilical mesenchymal stem cells have the potential for treatment of Parkinson's disease...
  78. pmc Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity
    Petter S Woll
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 113:6094-101. 2009
    ..These studies demonstrate that hESCs provide an important model to study human lymphocyte development and may serve as a novel source for antitumor immunotherapy...
  79. ncbi Generation of induced pluripotent stem cells from human cord blood
    Alexandra Haase
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Cell Stem Cell 5:434-41. 2009
    ..CB could readily become available for pediatric patients and, in particular, for newborns with genetic diseases or congenital malformations...
  80. ncbi Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation
    Didier Bouscary
    Departement d Hematologie, Institut Cochin, Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique, UMR 8104, Universite Rene Descartes, Paris, France
    Blood 101:3436-43. 2003
    ....
  81. pmc Exposure of cord blood to Mycobacterium bovis BCG induces an innate response but not a T-cell cytokine response
    M L V Watkins
    Division of Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Clin Vaccine Immunol 15:1666-73. 2008
    ..NK cell-derived IFN-gamma produced in naïve neonates likely plays a key protective role via monocyte activation and the priming of a subsequent adaptive Th1 response...
  82. ncbi Cord-blood transplants from unrelated donors in patients with Hurler's syndrome
    Susan L Staba
    Pediatric Stem Cell Transplant Program, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 350:1960-9. 2004
    ..We investigated the feasibility of using cord-blood transplants from unrelated donors and a myeloablative preparative regimen that did not involve total-body irradiation in young children with Hurler's syndrome...
  83. pmc Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial
    M De Lima
    Department of Stem Cell Transplantation and Cell Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Bone Marrow Transplant 41:771-8. 2008
    ..Median time to neutrophil and platelet engraftment was 30 (range, 16-46) and 48 (range, 35-105) days. There were no cases of grades 3-4 acute graft-versus-host disease (GVHD) and 100-day survival was 90%. This strategy is feasible...
  84. ncbi Concentrations of xenobiotic chemicals in the maternal-fetal unit
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    Reprod Toxicol 23:260-6. 2007
    ..Many xenobiotic chemicals have been shown to pass through the placental barrier and into the fetal blood stream...
  85. pmc Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway
    Venkata Ramesh Dasari
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA
    PLoS ONE 5:e10350. 2010
    ..Based on this capability, new therapeutic approaches have been developed using mesenchymal stem cells to cure glioblastoma. However, molecular mechanisms of interactions between glioma cells and stem cells are still unknown...
  86. pmc Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESS
    Junenette L Peters
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
    J Allergy Clin Immunol 123:1041-6. 2009
    ..Whereas some evidence suggests that antigen sensitization may begin prenatally, the influence of maternal allergen exposure during pregnancy has not been fully elucidated...
  87. ncbi Population cohort associating chorioamnionitis, cord inflammatory cytokines and neurologic outcome in very preterm, extremely low birth weight infants
    Tuula Kaukola
    Department of Pediatrics, University of Oulu, FIN 90014 Oulu, Finland
    Pediatr Res 59:478-83. 2006
    ..We propose that HCA together with other insults (placental perfusion defect or maternal systemic infection) increases the risk of poor neurologic outcome in very preterm ELBW infants...
  88. pmc Cord blood stem cell-mediated induction of apoptosis in glioma downregulates X-linked inhibitor of apoptosis protein (XIAP)
    Venkata Ramesh Dasari
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
    PLoS ONE 5:e11813. 2010
    ..We hypothesized that downregulation of XIAP by human umbilical cord blood mesenchymal stem cells (hUCBSC) in glioma cells would cause them to undergo apoptotic death...
  89. ncbi Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development
    Shunsuke Takei
    Department of Histology and Embryology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Am J Physiol Heart Circ Physiol 296:H1793-803. 2009
    ..These findings showed that BMP-4 in combination with FBS at the appropriate time and concentrations significantly promotes cardiomyocyte induction from human ES cells...
  90. ncbi Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia
    Vanderson Rocha
    Hopital Saint Louis, Assistance Publique des Hôpitaux de Paris and Paris University, Paris, France
    N Engl J Med 351:2276-85. 2004
    ..Promising results of cord-blood transplants from unrelated donors have been reported in adults...
  91. ncbi Fine specificity of neonatal lymphocytes to an abundant malaria blood-stage antigen: epitope mapping of Plasmodium falciparum MSP1(33)
    Indu Malhotra
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 180:3383-90. 2008
    ..We conclude that the fetal malaria response functions in a fully adaptive manner and that this response may serve to help protect the infant from severe malaria during infancy...
  92. ncbi Cord blood levels of interleukin-6 and interleukin-8 for the immediate diagnosis of early-onset infection in premature infants
    M Krueger
    University Children s Hospital, University of Freiburg, Germany
    Biol Neonate 80:118-23. 2001
    ..This study aimed at evaluating the significance of cord blood levels of interleukin (IL)-6 and IL-8 determined by a fully automated random access assay within 90 min of admission to predict systemic bacterial infection...
  93. ncbi Relation of cord serum levels of growth hormone, insulin-like growth factors, insulin-like growth factor binding proteins, leptin, and interleukin-6 with birth weight, birth length, and head circumference in term and preterm neonates
    Hui Chen Lo
    Department of Medical Education and Research, Changhua Christian Hospital, 135 Nanhsia Street, Changhua 500, Taiwan, Republic of China
    Nutrition 18:604-8. 2002
    ..Fetal growth process is governed by multiple factors. We investigated the relation of insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs), leptin, and interleukin-6 (IL-6) with intrauterine growth in preterm and term neonates...
  94. ncbi Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function
    Miranda Smith
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 121:1460-6, 1466.e1-7. 2008
    ..The role of regulatory T (Treg) cells in allergic predisposition is not known...
  95. ncbi Endothelial colony forming cells and mesenchymal stem cells are enriched at different gestational ages in human umbilical cord blood
    M Jawad Javed
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Pediatr Res 64:68-73. 2008
    ..These studies demonstrate that circulating MSCs and ECFCs appear at different GA in the human UCB, and that 24-28 wk GA UCB may be a novel source of MSCs for therapeutic use in human diseases...
  96. ncbi Prenatal exposure to a farm environment modifies atopic sensitization at birth
    Markus Johannes Ege
    University Children s Hospital, Munich, Germany
    J Allergy Clin Immunol 122:407-12, 412.e1-4. 2008
    ..Previous cross-sectional surveys have suggested that maternal exposure to animal sheds during pregnancy exerted a protective effect on atopic sensitization in children lasting until school age...
  97. ncbi Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues
    Keon Hee Yoo
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Cell Immunol 259:150-6. 2009
    ..These findings suggest that MSCs derived from AT, CB, or WJ could be substituted for BM-MSCs for treatment of allogeneic conflicts...
  98. ncbi Lead and other trace metals in preeclampsia: a case-control study in Tehran, Iran
    Mohsen Vigeh
    Department of Public Health, Graduate School of Medicine, The University of Tokyo, Hongo Bunkyo ku, Tokyo, Japan
    Environ Res 100:268-75. 2006
    ..Further studies are necessary to confirm these findings, especially on Sb and Mn...
  99. pmc Induction of apoptosis in glioma cells requires cell-to-cell contact with human umbilical cord blood stem cells
    Christopher S Gondi
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA
    Int J Oncol 36:1165-73. 2010
    ..Taken together, these results demonstrate that hUCB have therapeutic potential with possible clinical implications...
  100. pmc A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential
    Gesine Kogler
    Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Center, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Exp Med 200:123-35. 2004
    ..No tumor formation was observed in any of these animals...
  101. ncbi Differentiation of umbilical cord blood-derived multilineage progenitor cells into respiratory epithelial cells
    M J Berger
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Cytotherapy 8:480-7. 2006
    ..We report differentiation of human UCB-derived multipotent stem cells, termed multilineage progenitor cells (MLPC), into respiratory epithelial cells (i.e. type II alveolar cells)...

Research Grants62

  1. The baroreflex in pregnancy: effects of adrenal and placental steroids
    Maureen Keller-Wood; Fiscal Year: 2012
    ..This model also causes reduced fetal blood pressure and increased incidence of fetal hypoxia and fetal and maternal death...
  2. Cellular Mechanisms of Amniotic Fluid Volume Regulation
    Cecilia Y Cheung; Fiscal Year: 2013
    ..The current understanding suggests that the transfer of AF water and solutes across the fetal membranes into fetal blood vessels that vascularize the surface of the placenta is the pathway where regulation occurs...
  3. Role of natriuretic peptides in the ductus arteriosus
    JOHN JEFFREY REESE; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The ductus arteriosus is a fetal blood vessel whose patency is critical for survival in the womb due to its role in transmitting oxygenated blood from ..
  4. Endothelial Progenitor Cell Transplant to Accelerate Hematopoietic Recovery
    John P Chute; Fiscal Year: 2011
    ..relevant model, we propose the following Specific Aims: 1) Determine whether transplantation of primary fetal blood EPCs can enhance hematopoietic recovery in a murine model of fetal blood transplantation, 2) Determine whether ..
  5. The maternal-fetal adiponectin differential and fetal fat deposition
    Jianhua Shao; Fiscal Year: 2013
    ..that maternal obesity increases fetal mouse fat tissue mass with a significant elevation of adiponectin in fetal blood. However, in adiponectin gene knockout (Adipoq-/-) mice, maternal obesity failed to increase fetal body weight ..
  6. FETAL CARDIOVASCULAR AND ENDOCRINE REFLEX RESPONSES
    Charles E Wood; Fiscal Year: 2013
    ..provided by applicant): Baroreceptor and chemoreceptor reflexes are actively involved in the control of fetal blood pressure and in the maintenance of blood flow to the placenta and to the metabolizing tissues...
  7. Role of nitrite and hemoglobin in vascular NO homeostasis in the fetus and adult
    Arlin B Blood; Fiscal Year: 2013
    ..In the third aim, in vitro studies are proposed which will determine whether fetal blood is more effective than adult blood at producing vasoactive quantities of NO from nitrite...
  8. Fetal Endocrine Disruption by Triclosan
    Charles E Wood; Fiscal Year: 2012
    ..The placenta provides nearly all of the estrogen that circulates in fetal blood, through secretion in the form of sulfate conjugates of estradiol and related estrogens...
  9. Skin Regeneration: Cellular &Molecular Mechanisms
    HERMANN PETER LORENZ; Fiscal Year: 2012
    ..Dot cells are present in the blood of fetal and adult mice and humans. The percentage of Dot cells in fetal blood is about twenty-times higher than in blood of four-week old mice. 2...
  10. THE EFFECTS OF COCAINE ON FETAL OXYGENATION
    James Woods; Fiscal Year: 1993
    ..maternal femoral and uterine blood flow measurements and fetal arterial and venous catheters will be placed for fetal blood pressure, heart rate, and blood gas (p02, 02 content, pC02, pH) levels...
  11. EXPERIMENTAL MODEL FOR CHORIOAMNIONITIS AND PREMATURITY
    Michael Gravett; Fiscal Year: 2005
    ..Uterine contractility will be continuously monitored and periodic samples of amniotic fluid and maternal and fetal blood (1-4 cc) will be obtained for assays of eicosanoids, steroid hormones, cytokines, matrix metalloproteinases and ..
  12. Mouse Model For Amniotic Fluid Volume Regulation
    CECILIA CHEUNG; Fiscal Year: 2002
    ..a vascular pathway within the fetal membranes for the transfer of fluid from the amniotic compartment into the fetal blood. This pathway is constituted by a network of microvessels on the surface of the placenta and, in sheep, within ..
  13. REGULATION OF VEGF EXPRESSION IN PLACENTA AND MEMBRANES
    CECILIA CHEUNG; Fiscal Year: 2004
    ..membranes and fetal surface of the placenta for fluid and solute exchange between the amniotic compartment and fetal blood. This pathway is an important determinant of amniotic fluid volume...
  14. INTESTINAL & PLACENTAL FC-RECEPTORS FOR IMMUNOGLOBULIN
    Neil Simister; Fiscal Year: 2000
    ..The presence of the receptor in one or both of the cellular barriers between maternal and fetal blood, the syncytiotrophoblast and fetal vessel endothelia, would be consistent with a transport role...
  15. Dissociating hypoxia from pathology in preeclampsia and*
    Stacy Zamudio; Fiscal Year: 2007
    ..to placental morphology, and the expression of placental nutrient transporters in relation to maternal and fetal blood flow...
  16. FETAL RESPONSES TO SULFOCONJUGATED ESTROGENS
    Charles Wood; Fiscal Year: 2001
    ..is highly logical, given the high activity of STS within the fetal brain and given the incomplete nature of the fetal blood-brain barrier...
  17. Early Predictors of Postpartum Depression
    ILONA YIM; Fiscal Year: 2009
    ..Specifically, corticotropin releasing hormone (CRH) is released into the maternal and fetal blood stream by the placenta, resulting in exponential CRH increase as pregnancy progresses...
  18. Transcriptional Control of Placental Development
    Yaacov Barak; Fiscal Year: 2007
    ..These defects, in turn, abrogate the penetration of fetal blood vessel into the placenta, and severely disrupt the trophoblast-lined maternal vascular interface in the organ...
  19. Perfusion System for In Utero Cardiac Surgery
    SARAH MONTAG; Fiscal Year: 2007
    ..utilizing computational fluid dynamics (CFD) techniques to optimize and subsequently freeze the designs of the fetal blood pump and miniature oxygenator developed during our Phase I work, 2) fabricating a sufficient number of ..
  20. FETAL LYMPH FLOW DYNAMICS AND CONTROL
    ROBERT BRACE; Fiscal Year: 1993
    ..of whole-body lymph flow in the normal fetus but they will also provide insights into the understanding of fetal blood volume regulation, fetal fluid balance, and clinical problems such as non- immune hydrops fetalis (ie, fetal ..
  21. CORD BLOOD COLLECTION DEVICE
    RICHARD MEYST; Fiscal Year: 2000
    ..will offer to the medical community a means to collect with high reliability and safety a valuable source of fetal blood cells capable of supporting restoration of the hematopoietic system in individuals with cancer and inherited ..
  22. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 2001
    ..6 and 0.7 ga, and that fluctuations in fetal blood pressure due to post asphyxial NMDA mediated seizures at 0...
  23. FETAL NUTRIENT THERAPY: EFFECTS ON GROWTH RETARDATION
    Valerie Charlton; Fiscal Year: 1992
    ..Hormones measured will be GH, insulin, somatomedin-C/IGF1, prolactin, and oCS. Maternal and fetal blood flow will be determined prospectively with an antipyrine technique; flow distribution will be determined with ..
  24. LONG-TERM REGULATION OF BLOOD VOLUME BY THE FETUS
    Debra Anderson; Fiscal Year: 1993
    ..Regulation of fetal blood volume is subject to constraints which do not exist in the adult...
  25. Ontogenic changes in erythroid gene expression
    MARCUS MUENCH; Fiscal Year: 2005
    Erythropoiesis dominates hematopoiesis during fetal life to accommodate the rapid expansion in fetal blood volume...
  26. COCAINE--EFFECT ON FETAL BRAIN METABOLISM AND FUNCTION
    David Burchfield; Fiscal Year: 2000
    ..of pregnancy after which we will study maternal blood pressure, heart rate and uterine blood flow as well as fetal blood pressure, heart rate, behavioral state, hypothalamic-pituitary-adrenal axis hormones and cerebral and ..
  27. ANGIOTENSIN II AND NEPHROGENESIS IN VITRO
    TERI MAUCH; Fiscal Year: 2002
    ..effects of AII modulate fetal renal development, and that these actions occur even in the absence of altered fetal blood flow...
  28. GENETIC CONTROL OF DIPHOSPHOGLYCERATE IN FETAL BLOOD
    JOHN GILMAN; Fiscal Year: 1980
    ..The study should also increase our knowledge of the functioning of red cells during mammalian embryonic and fetal life...
  29. MECHANISMS OF ALCOHOLS EFFECTS ON BONE METABOLISM
    KATHERINE KEIVER; Fiscal Year: 2000
    ..decrease in maternal blood iCa levels retards fetal growth and skeletal development by causing a decrease in fetal blood iCa levels, which may a) inhibit bone formation directly, or b) trigger a compensatory response by the fetus, ..
  30. EFFECT OF HCGNRH ON HUMAN PLACENTAL PROSTANOID
    Theresa Siler Khodr; Fiscal Year: 1990
    ..Due to the very important role of prostanoids in implantation, in placental and fetal blood flow and in the initiaion and progress of labor, these studies may provide needed information which may be able ..
  31. CONSEQUENCES OF FETAL HYPOXIA ON THE NEONATAL CNS
    W Lust; Fiscal Year: 1999
    ..by quantitative histochemical measurement of metabolites in nanogram pieces of brain, nanoliters of CSF and in fetal blood. The resulting biochemical profile of the various fetal brain compartments from E11 to E21 will reflect ..
  32. CRITICAL REAGENTS THAT SUPPORT FETAL HEMATOPOIESIS
    Ronald Brown; Fiscal Year: 1993
    ..Such an in vitro system will be valuable in assessing the changes in fetal blood populations during ontogeny...
  33. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  34. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  35. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ....
  36. Mesenchymal Stem Cells for Fetal Gene Delivery
    Alice Tarantal; Fiscal Year: 2006
    ..abstract_text> ..
  37. Center for Fetal Gene Transfer for HLB Diseases
    Alice Tarantal; Fiscal Year: 2005
    ..abstract_text> ..
  38. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  39. SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS
    Charles Wood; Fiscal Year: 2008
    ..The emphasis of this training program in the next five years will be to significantly expand the students' horizons and to recruit students into basic biomedical science. ..
  40. Estrogen Influences on Fetal Adrenocorticotropin
    Charles Wood; Fiscal Year: 2006
    ..abstract_text> ..
  41. Center for Pediatric Stem/Progenitor Cell Translational Research
    Alice Tarantal; Fiscal Year: 2008
    ..If imaging techniques can be developed that allows one to monitor the cells over time, this would provide a very powerful tool to determine the fate of the cells after injection into humans. ..
  42. Aberrant Ovine Pancreatic Development in IUGR Fetuses
    Sean Limesand; Fiscal Year: 2007
    ....
  43. ANDROGENIZED FEMALE AS A MODEL FOR P0LYCYSTIC OVARIAN SY
    David Abbott; Fiscal Year: 2002
    ..Such results would offer novel insights into the origin and mechanism of PCOS, and would provide a unifying determinant for a multifactorial syndrome. ..
  44. Polymorphism of Multi-Drug-Resistance Protein-1
    RODNEY HO; Fiscal Year: 2005
    ....
  45. Clinical trial of leptin for hypothalamic amenorrhea
    Christos Mantzoros; Fiscal Year: 2005
    ..Support is needed to finalize key study design issues, establish collaborative arrangements for a multi-center study, develop an infrastructure for conducting a RCT, and plan subject recruitment strategies. ..
  46. CNS specific Knock-out and Multidrug Transport
    RODNEY HO; Fiscal Year: 2006
    ..The potential benefits to overall biomedical research outweigh the calculated risks associated with this exploratory research. ..
  47. Bilirubin-induced Auditory Neuropathy in Preterms
    SANJIV AMIN; Fiscal Year: 2008
    ..abstract_text> ..
  48. Role of Leptin in the Neuroendocrine Response to Fasting
    Christos S Mantzoros; Fiscal Year: 2011
    ..abstract_text> ..
  49. Measurement & modulation of the mutation rate in humans
    David Araten; Fiscal Year: 2007
    ..These studies will begin to elucidate the relationship between f and cancer risk and provide a highly relevant in vitro parameter with which to evaluate chemoprevention. ..
  50. Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary Embolism
    Carlos Camargo; Fiscal Year: 2008
    ..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..
  51. HYPOXIA EFFECTS ON AMNIOTIC FLUID VOLUME
    ROBERT BRACE; Fiscal Year: 2008
    ..This knowledge will promote a rational basis for improved therapies to treat AF volume abnormalities, thereby helping to reduce fetal and neonatal morbidity and mortality. ..
  52. Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children
    Carlos Camargo; Fiscal Year: 2008
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of asthma. [unreadable] [unreadable] [unreadable] [unreadable]..
  53. DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Carlos Camargo; Fiscal Year: 2002
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..