kainic acid

Summary

Summary: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.

Top Publications

  1. ncbi Edaravone prevents kainic acid-induced neuronal death
    Ryohei Miyamoto
    Department of Pediatrics, Osaka Medical College, Japan
    Brain Res 1209:85-91. 2008
  2. pmc The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:6964-72. 2009
  3. ncbi Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration
    L C Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, 72079 9502, Jefferson, AR 72079 9502, USA
    Brain Res 874:123-30. 2000
  4. pmc miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132
    Eva M Jimenez-Mateos
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Am J Pathol 179:2519-32. 2011
  5. ncbi Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions
    Alok K Sharma
    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA
    Toxicol Pathol 35:984-99. 2007
  6. ncbi Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:9400-7. 2007
  7. ncbi Kainic acid-mediated excitotoxicity as a model for neurodegeneration
    Qun Wang
    Department of Medical Pharmacology, University of Missouri School of Medicine, Columbia, MO, USA
    Mol Neurobiol 31:3-16. 2005
  8. pmc Development of spontaneous recurrent seizures after kainate-induced status epilepticus
    Philip A Williams
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 29:2103-12. 2009
  9. ncbi Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus
    E J Baik
    Department of Physiology, School of Medicine, Ajou University, Suwon, South Korea
    Brain Res 843:118-29. 1999
  10. pmc Kainic acid-induced neurodegenerative model: potentials and limitations
    Xiang Yu Zheng
    Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China
    J Biomed Biotechnol 2011:457079. 2011

Detail Information

Publications323 found, 100 shown here

  1. ncbi Edaravone prevents kainic acid-induced neuronal death
    Ryohei Miyamoto
    Department of Pediatrics, Osaka Medical College, Japan
    Brain Res 1209:85-91. 2008
    ..treat cerebral infarction, could prevent neuronal loss when administered after the occurrence of seizures in a kainic acid (KA)-induced seizure model...
  2. pmc The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:6964-72. 2009
    ..These findings indicate that mTOR signaling mediates mechanisms of epileptogenesis in the kainate rat model and that mTOR inhibitors have potential antiepileptogenic effects in this model...
  3. ncbi Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration
    L C Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, 72079 9502, Jefferson, AR 72079 9502, USA
    Brain Res 874:123-30. 2000
    ..Like Fluoro-Jade, Fluoro-Jade B is compatible with a number of other labeling procedures including immunofluorescent and fluorescent Nissl techniques...
  4. pmc miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132
    Eva M Jimenez-Mateos
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Am J Pathol 179:2519-32. 2011
    ..how prior seizure preconditioning affects the miRNA response to status epilepticus evoked by intra-amygdalar kainic acid in mice...
  5. ncbi Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions
    Alok K Sharma
    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA
    Toxicol Pathol 35:984-99. 2007
    ..Among post-status epilepticus models, induction of systemic kainic acid or pilocarpine-induced epilepsy is less labor-intensive than electrical-stimulation models and these models ..
  6. ncbi Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:9400-7. 2007
    ....
  7. ncbi Kainic acid-mediated excitotoxicity as a model for neurodegeneration
    Qun Wang
    Department of Medical Pharmacology, University of Missouri School of Medicine, Columbia, MO, USA
    Mol Neurobiol 31:3-16. 2005
    ..b>Kainic acid (KA) is an agonist for a subtype of ionotropic glutamate receptor, and administration of KA has been shown to ..
  8. pmc Development of spontaneous recurrent seizures after kainate-induced status epilepticus
    Philip A Williams
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 29:2103-12. 2009
    ....
  9. ncbi Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus
    E J Baik
    Department of Physiology, School of Medicine, Ajou University, Suwon, South Korea
    Brain Res 843:118-29. 1999
    ..This study examined the role of COX-2 in kainic acid-induced seizure and in the following neuronal death by using selective inhibitors...
  10. pmc Kainic acid-induced neurodegenerative model: potentials and limitations
    Xiang Yu Zheng
    Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China
    J Biomed Biotechnol 2011:457079. 2011
    ..However, the mechanism by which excitotoxicity is implicated in neurodegenerative disorders remains unclear. Kainic acid (KA) is an epileptogenic and neuroexcitotoxic agent by acting on specific kainate receptors (KARs) in the CNS...
  11. pmc Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity
    Maryla Krajewska
    Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e24341. 2011
    ..Given the critical position of caspase 8 at the crossroads of cell death pathways, we generated a new viable mouse line (Ncasp8(-/-)), in which the gene encoding caspase 8 was selectively deleted in neurons by cre-lox system...
  12. ncbi Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation
    Chia Fu Chang
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    J Pineal Res 52:312-21. 2012
    In this study, the protective effect of melatonin on kainic acid (KA)-induced neurotoxicity involving autophagy and α-synuclein aggregation was investigated in the hippocampus of C57/BL6 mice...
  13. ncbi Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid
    J Widenfalk
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Neurosci 21:3457-75. 2001
    ..Injuries in adult rats included weight-drop, transection, and excitotoxic kainic acid delivery; in newborn rats, partial transection was performed...
  14. ncbi Exercise, but not environmental enrichment, improves learning after kainic acid-induced hippocampal neurodegeneration in association with an increase in brain-derived neurotrophic factor
    O L Gobbo
    Department of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Behav Brain Res 159:21-6. 2005
    ..To evaluate the neuroprotective effect of these conditions, we used the kainic acid (KA) model of neuronal injury...
  15. ncbi Kainate receptors in epilepsy and excitotoxicity
    P Vincent
    Laboratoire Physiologie Cellulaire de la Synapse, CNRS UMR5091, Bordeaux Neuroscience Institute, University of Bordeaux 2, 33077 Bordeaux, France
    Neuroscience 158:309-23. 2009
    ..Finally, we report recent findings proposing KARs as targets of antiepileptic drugs and neuroprotective agents...
  16. ncbi Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
    A Behrens
    Research Institute of Molecular Pathology, Vienna, Austria
    Nat Genet 21:326-9. 1999
    ..Our results provide evidence that JNP is dispensable for mouse development, and identify c-Jun as the essential substrate of JNK signalling during kainate-induced neuronal apoptosis...
  17. pmc Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus
    T Engel
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Cell Death Dis 1:e79. 2010
    ..Analysis of electroencephalogram (EEG) recordings during status epilepticus induced by intra-amygdala kainic acid (KA) showed that seizures lasted significantly longer in p53-deficient mice compared with wild-type animals...
  18. pmc EEG spike activity precedes epilepsy after kainate-induced status epilepticus
    Andrew White
    Department of Pediatrics and Neurology, School of Medicine, University of Colorado Health Sciences Campus, Denver, Colorado 80262, USA
    Epilepsia 51:371-83. 2010
    ....
  19. ncbi Kainate induces AKT, ERK and cdk5/GSK3beta pathway deregulation, phosphorylates tau protein in mouse hippocampus
    N Crespo-Biel
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Neurochem Int 50:435-42. 2007
    ..Taken together, our results provide new insights in the activation of several kinase-pathways implicated in cytoskeletal alterations that are a common feature of neurodegenerative diseases...
  20. ncbi Domoic acid induced spinal cord lesions in adult mice: evidence for the possible molecular pathways of excitatory amino acids in spinal cord lesions
    Renshi Xu
    Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
    Neurotoxicology 29:700-7. 2008
    ....
  21. ncbi Cloning, expression and characterisation of a single-chain Fv antibody fragment against domoic acid in Escherichia coli
    Xuejun Hu
    Department of Chemical and Environmental Sciences, University of Limerick, Plassey Technology Park, Limerick, Ireland
    J Biotechnol 120:38-45. 2005
    ..The purified scFv exhibited binding similar to the parent monoclonal antibody and is being used to develop an immunosensor to detect domoic acid in contaminated shellfish samples...
  22. ncbi Non-invasive imaging of GFAP expression after neuronal damage in mice
    Lingyun Zhu
    Xenogen Corporation, 860 Atlantic Avenue, Alameda, CA 94501, USA
    Neurosci Lett 367:210-2. 2004
    ..Biophotonic imaging was used to non-invasively detect the increase in GFAP expression after kainic acid induced neuronal cell death...
  23. pmc Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy
    J E Cavazos
    Department of Medicine Neurology and Pharmacology, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Neuroscience 126:677-88. 2004
    ..in the stratum lacunosum-moleculare of CA1 in three acute and two chronic models of TLE: intraventricular kainic acid (KA), systemic KA, systemic pilocarpine, chronic electric kindling and chronic i.p. pentylenetetrazol...
  24. ncbi Inhibition of delayed induction of p38 mitogen-activated protein kinase attenuates kainic acid-induced neuronal loss in the hippocampus
    Seung Woo Kim
    Department of Anatomy, Inha University School of Medicine, 7 241 Shinheung dong, Jung Gu, Inchon, 400 712, South Korea
    Brain Res 1007:188-91. 2004
    ..In a kainic acid (KA)-induced mouse seizure model, p38 MAPK is induced in reactive astrocytes in the CA3 region of the ..
  25. ncbi A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide
    C Culmsee
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore 21224, USA
    J Neurochem 77:220-8. 2001
    ....
  26. ncbi Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures
    Daisuke Tsuchiya
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    Neurosurgery 53:1179-87; discussion 1187-8. 2003
    ..The effects of hsp70 overexpression were also evaluated after transient global ischemia or kainic acid (KA)-induced seizures, to verify the results in other excitotoxic stress models.
  27. ncbi Neuroprotective effects of neuropeptide Y-Y2 and Y5 receptor agonists in vitro and in vivo
    Maria Śmiałowska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropeptides 43:235-49. 2009
    ..The obtained results indicate that neuropeptide Y produces neuroprotective effect via Y2 and Y5 receptors, and that the compounds may be effective after delayed application...
  28. ncbi Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death
    Juha T Järvelä
    Department of Pharmacology, Drug Development, and Therapeutics, Institute of Biomedicine, University of Turku, Itainen Pitkakatu 4B, FIN 20014 Turku, Finland
    Neuropharmacology 60:1116-25. 2011
    ..In this study, we investigated the role of inflammatory mediators in kainic acid (KA)-induced neuronal damage in organotypic hippocampal slice cultures (OHCs)...
  29. ncbi Enhanced neurogenesis in organotypic cultures of rat hippocampus after transient subfield-selective excitotoxic insult induced by domoic acid
    A Perez-Gomez
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PEI, Canada
    Neuroscience 208:97-108. 2012
    ..DOM is an excitatory amino acid analog to kainic acid that acts through glutamate receptors to elicit a rapid and potent excitotoxic response...
  30. ncbi p53 mediates autophagy activation and mitochondria dysfunction in kainic acid-induced excitotoxicity in primary striatal neurons
    X X Dong
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases SZS0703, Soochow University, School of Pharmaceutical Science, Wen Jing Road, Suzhou 215123, China
    Neuroscience 207:52-64. 2012
    ..to investigate if p53 mediates autophagy activation and mitochondria dysfunction in primary striatal neurons in kainic acid (KA)-induced excitotoxicity. The excitotoxic model of primary striatal neurons was established with KA...
  31. ncbi Hypometabolism precedes limbic atrophy and spontaneous recurrent seizures in a rat model of TLE
    Bianca Jupp
    Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
    Epilepsia 53:1233-44. 2012
    ..This study aimed to investigate the ontologic relationship among limbic atrophy, histological changes, and hypometabolism in rats...
  32. ncbi Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis
    Wan Yu Lo
    Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan
    Am J Chin Med 38:745-59. 2010
    ..the effect of (UR) on the expression of proteins using a proteomics analysis in Sprague-Dawley (SD) rats with kainic acid (KA)-induced epileptic seizures...
  33. ncbi Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures
    Gunther Sperk
    Department of Pharmacology, University of Innsbruck, Innsbruck, Austria
    Hippocampus 13:806-15. 2003
    b>Kainic acid-induced seizures cause a marked increase in the expression of glutamate decarboxylase 67 (GAD67) in granule cells of the dentate gyrus...
  34. ncbi Epileptic tolerance is associated with enduring neuroprotection and uncoupling of the relationship between CA3 damage, neuropeptide Y rearrangement and spontaneous seizures following intra-amygdala kainic acid-induced status epilepticus in mice
    E M Jimenez-Mateos
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Neuroscience 171:556-65. 2010
    ..These data show that tolerance-conferred neuroprotection is long-lasting and that tolerance disrupts the normal association between CA3 damage, synaptic rearrangement and occurrence of spontaneous seizures in this model...
  35. pmc Iron enrichment stimulates toxic diatom production in high-nitrate, low-chlorophyll areas
    Charles G Trick
    Departments of Biology, and Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A5B7, Canada
    Proc Natl Acad Sci U S A 107:5887-92. 2010
    ..Given the negative effects of DA in coastal food webs, these findings raise serious concern over the net benefit and sustainability of large-scale iron fertilizations...
  36. ncbi Effect of ageing on CA3 interneuron sAHP and gamma oscillations is activity-dependent
    Cheng B Lu
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Neurobiol Aging 32:956-65. 2011
    ....
  37. ncbi Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for
    Hafiz Mohmmad Abdul
    Department of Chemistry and Center of Membrane Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
    J Neurochem 96:1322-35. 2006
    ..those from wild-type mice, in the presence or absence of various oxidizing agents, viz, Abeta(1-42), H2O2 and kainic acid (KA)...
  38. ncbi Activation of Rho after traumatic brain injury and seizure in rats
    Catherine I Dubreuil
    Universite de Montreal, 2900 Edouard Montpetit, Faculte de Medecine, Departement de pathologie et biologie cellulaire, Montreal, QC, Canada H3T 1J4
    Exp Neurol 198:361-9. 2006
    ..post-traumatic events such as seizures may activate Rho, we examined RhoA activation in the brains of rats with kainic acid-induced seizures. Severe seizures resulted in bilateral RhoA activation in the cortex and hippocampus...
  39. ncbi Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice
    Kazuyasu Chihara
    Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kihara, Kiyotake, Miyazaki, Japan
    J Neurochem 110:956-65. 2009
    ..examined the roles of OASIS in neuronal degeneration in the hippocampi of mice intraperitoneally injected with kainic acid (KA)...
  40. pmc Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death
    Ik Hyun Cho
    Program in Molecular and Cellular Neuroscience, DRI, and Department of Oral Physiology, School of Dentistry, Seoul National University, Seoul, Korea
    Brain 131:3019-33. 2008
    ..b>Kainic acid (KA)-induced hippocampal neuronal cell death was reduced by 30% in LysM-Cre/Ikkbeta(F/F) mice compared with ..
  41. ncbi Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats
    Zheng Wu
    Department of Physiology, School of Basic Medical Science, Anhui Medical University, 230032 Hefei, China
    Neurochem Res 34:1393-400. 2009
    ..These results suggest that Res is a potent anti-epilepsy agent, which protects against epileptogenesis and progression of the kainate-induced TLE animal...
  42. ncbi TNF-alpha receptor 1 deficiency enhances kainic acid-induced hippocampal injury in mice
    Ming Ou Lu
    Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
    J Neurosci Res 86:1608-14. 2008
    The exact role of TNF-alpha in excitotoxic neurodegeneration of the brain is unclear. To address this issue, the kainic acid (KA)-induced hippocampal injury model, a well-characterized model of human neurodegenerative diseases, was used ..
  43. ncbi Melatonin attenuates kainic acid-induced hippocampal neurodegeneration and oxidative stress through microglial inhibition
    Seung Yun Chung
    Department of Pediatrics, Our Lady of Mercy Hospital, Catholic University Medical College, Inchon, Korea
    J Pineal Res 34:95-102. 2003
    The antioxidant and anti-inflammatory effects of melatonin on kainic acid (KA)-induced neurodegeneration in the hippocampus were evaluated in vivo...
  44. pmc Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathways
    Stephane Martin
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol, UK
    EMBO J 23:4749-59. 2004
    ..These results demonstrate that GluR6-containing KARs are subject to activity-dependent endocytic sorting, a process that provides a mechanism for both rapid and chronic changes in the number of functional receptors...
  45. ncbi Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats
    P S Buckmaster
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523, USA
    J Comp Neurol 385:385-404. 1997
    ..Adult rats were treated systemically with kainic acid, and, months later, after displaying spontaneous recurrent motor seizures, their dentate gyri were examined...
  46. ncbi Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region
    Takako Takemiya
    Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Neurosci Res 56:103-10. 2006
    Injection of kainic acid (KA) into the brain causes severe seizures with hippocampal neuron loss...
  47. ncbi Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains
    Jessica Pilar McLin
    Reeve Irvine Research Center, 1105 Gillespie Neuroscience Research Facility, University of California at Irvine, Irvine, CA 92697 4292, USA
    Eur J Neurosci 24:2191-202. 2006
    ..hybrid mouse strains for susceptibility to seizures and neurodegeneration induced by systemic administration of kainic acid (KA)...
  48. ncbi NAD(P)H fluorescence imaging of postsynaptic neuronal activation in murine hippocampal slices
    C William Shuttleworth
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    J Neurosci 23:3196-208. 2003
    ....
  49. pmc Kainate seizures cause acute dendritic injury and actin depolymerization in vivo
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:11604-13. 2007
    ....
  50. ncbi Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice
    Genshin Mouri
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin, 2, Ireland
    Brain Res 1213:140-51. 2008
    ..We previously developed a model of focally-evoked seizure-induced neuronal death using intra-amygdala kainic acid (KA) microinjection and characterized the acute hippocampal pathology...
  51. ncbi Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation
    Farah D Lubin
    Cain Foundation Laboratories, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA, and Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurochem 103:1381-95. 2007
    ..In summary, our findings provide additional insights into the role of NF-kappaB transcriptional regulation in hippocampus following status epilepticus and suggest that NF-kappaB pathway activation contributes to seizure susceptibility...
  52. ncbi NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury
    Sookyong Koh
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Epilepsia 45:569-75. 2004
    ....
  53. ncbi Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta
    Honghua Zheng
    Department of Brain Research, Division of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Neuroimmunomodulation 17:31-8. 2010
    ....
  54. ncbi Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathology
    G M McKhann
    Department of Neurological Surgery, Columbia University, 710 West 168th Street, NI 42, New York, NY 10032, USA
    Neuroscience 122:551-61. 2003
    ..A subcutaneous (s.c.) kainic acid multiple injection protocol was developed...
  55. pmc Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration
    Jian Luo
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:18326-31. 2006
    ..In vivo excitatory stimulation with kainic acid (KA) resulted in an increase in luciferase activity and phosphorylated Smad2 (Smad2P), and nuclear ..
  56. ncbi CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
    Science 302:84-8. 2003
    ..In mutant mice,the excitotoxin kainic acid (KA) induced excessive seizures in vivo...
  57. ncbi An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid
    Yan Wang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases SZS0703, Soochow University School of Medicine, Suzhou, China
    Autophagy 4:214-26. 2008
    Previous studies found that kainic acid (KA)-induced apoptosis involved the lysosomal enzyme cathepsin B, suggesting a possible mechanism of autophagy in excitotoxicity...
  58. pmc Cholinergic activation and tonic excitation induce persistent gamma oscillations in mouse somatosensory cortex in vitro
    E H Buhl
    MRC Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, UK
    J Physiol 513:117-26. 1998
    ..These findings (re)emphasize the role of the cholinergic ascending system in the cortical processing of sensory information...
  59. ncbi Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors
    Silvia Balosso
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Ann Neurol 57:804-12. 2005
    ..This evidence highlights a novel function of TNF-alpha in brain and indicates a new system for anticonvulsive intervention...
  60. ncbi Mechanisms of kainate-induced region-specific neuronal death in immature organotypic hippocampal slice cultures
    I E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itainen Pitkakatu 4, FIN 0520 Turku, Finland
    Neurochem Int 45:1-10. 2004
    ..Electron microscopy showed non-apoptotic injury in the CA3a/b pyramidal neurons in KA-treated slices. Our results suggest that KA-induced neuronal death in immature OHCs is a strictly region-specific, irreversible, necrotic process...
  61. ncbi Effect of safranal on extracellular hippocampal levels of glutamate and aspartate during kainic Acid treatment in anesthetized rats
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
    Planta Med 74:1441-5. 2008
    ..P.; p < 0.001). The results of this study show that acute systemic injection of safranal reduces the extracellular concentrations of glutamate and aspartate in the rat hippocampus following KA administration...
  62. ncbi NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury
    A Josephson
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Exp Neurol 169:319-28. 2001
    ..Rat mRNA expression was also studied in a spinal cord weight-drop model and in animals exposed to kainic acid. In human fetal tissue, nogo-A was strongly expressed in the ventral two-thirds of the spinal cord, the dorsal ..
  63. ncbi Lipoprotein lipase and endothelial lipase expression in mouse brain: regional distribution and selective induction following kainic acid-induced lesion and focal cerebral ischemia
    E Paradis
    Department of Medical Biology, Faculty of Medicine, Laval University, Ste Foy PQ, Canada
    Neurobiol Dis 15:312-25. 2004
    ..into the role played by lipases in the brain, neurodegeneration was induced by intraperitoneal injection of kainic acid (KA) or by occlusion of the middle cerebral artery (MCA)...
  64. ncbi Involvement of the transcription factor E2F1/Rb in kainic acid-induced death of murine cerebellar granule cells
    Robert A Smith
    Experimental Stroke Group, NRC Institute for Biological Sciences, National Research Council of Canada, Building M54, 1500 Montreal Road, Ottawa, ON K1A 0R6, Canada
    Brain Res Mol Brain Res 116:70-9. 2003
    ..current study aimed to investigate the role of this transcription factor in modulating neuronal death following kainic acid (KA) treatment of cultured mouse cerebellar granule cells (CGCs)...
  65. ncbi Acupuncture inhibits kainic Acid-induced hippocampal cell death in mice
    Seung Tae Kim
    Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, Republic of Korea
    J Physiol Sci 58:31-8. 2008
    ..whether acupuncture can reduce both the incidence of seizures and hippocampal cell death using a mouse model of kainic acid (KA)-induced epilepsy...
  66. ncbi Toxicokinetics of domoic acid in the fetal rat
    Jennifer Maucher Fuquay
    National Oceanographic and Atmospheric Administration, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
    Toxicology 294:36-41. 2012
    ..This has implications for the California sea lions (Zalophus californianus), which exhibit an epilepsy-like disease that arises months after DA producing blooms...
  67. ncbi Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy
    Ulrike Seegers
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, Building 218, D 30559 Hannover, Germany
    Epilepsy Res 51:257-68. 2002
    ..Seizure-induced over-expression of PGP in capillary endothelial cells of the BBB is likely to reduce the penetration of AEDs into brain parenchyma, which could explain the drug-refractoriness of seizures in TLE...
  68. ncbi Protective effect of topiramate on kainic acid-induced cell death in mice hippocampus
    Hae Jeong Park
    Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
    Epilepsia 49:163-7. 2008
    ..We investigated the effect and signaling mediators of TPM on seizure-induced hippocampal cell death in kainic acid (KA)-treated ICR mice...
  69. pmc Changes in the expression of GABAA receptor subunit mRNAs in parahippocampal areas after kainic acid induced seizures
    Meinrad Drexel
    Department of Pharmacology, Innsbruck Medical University Innsbruck, Austria
    Front Neural Circuits 7:142. 2013
    ..ventral subiculum, EC, and perirhinal cortex (PRC) at different intervals (1, 8, 30, and 90 days) after kainic acid (KA)-induced status epilepticus priming epileptogenesis in the rat...
  70. ncbi Acute neurotoxicity of domoic acid in the rat
    L Tryphonas
    Toxicology Research Division, Health and Welfare Canada, Ottawa
    Toxicol Pathol 18:1-9. 1990
    ..The results of this study suggest that domoic acid is excitotoxic and causes a characteristic syndrome with clinical signs and histopathologic lesions similar to those reported for kainic acid.
  71. ncbi The kainic acid model of temporal lobe epilepsy
    Maxime Levesque
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, QC, Canada H3A 2B4
    Neurosci Biobehav Rev 37:2887-99. 2013
    The kainic acid model of temporal lobe epilepsy has greatly contributed to the understanding of the molecular, cellular and pharmacological mechanisms underlying epileptogenesis and ictogenesis...
  72. ncbi Effects of COX inhibitors on neurodegeneration and survival in mice exposed to the marine neurotoxin domoic acid
    James C Ryan
    Marine Biotoxins Program, NOAA Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
    Neurosci Lett 487:83-7. 2011
    ..This study shows that COX2 plays a role in DA induced neurodegeneration and death, and that inhibitors may be of value for treatment in human and wildlife DA exposure...
  73. ncbi Association of an unusual marine mammal mortality event with Pseudo-nitzschia spp. Blooms along the southern California coastline
    Gretel Torres de la Riva
    Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, 1 Shields Ave, California 95616, USA
    J Wildl Dis 45:109-21. 2009
    ..In addition, California sea lion-strandings appear to be a very sensitive indicator of DA in the marine environment, and their monitoring should be included in public health surveillance plans...
  74. ncbi A pharmacological investigation of the role of GLUK5-containing receptors in kainate-driven hippocampal gamma band oscillations
    J T Brown
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, New Frontiers Science Park North, Harlow, Essex, UK
    Neuropharmacology 50:47-56. 2006
    ....
  75. ncbi Domoic acid induced status epilepticus promotes aggressive behavior in rats
    Jennifer Maucher Fuquay
    National Oceanographic and Atmospheric Administration, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412, USA
    Physiol Behav 105:315-20. 2012
    ....
  76. ncbi Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats
    Binbin Qian
    Institutes of Brain Science, State Key Laboratory for Medical Neurobiology, Fudan University, Shanghai 200032, China
    Seizure 20:312-9. 2011
    ..CA1 neurons in response to CTZ in epileptogenesis in comparison with two other classic convulsants of kainic acid (KA) and pentylenetetrazol (PTZ). CTZ administered intracerebral ventricle (i.c.v...
  77. pmc Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death
    Seiichiro Jinde
    Unit on the Genetics of Cognition and Behavior, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, MD 20892, USA
    Eur J Neurosci 30:1036-55. 2009
    ..We assessed the relationship between kainic acid (KA)-induced gamma oscillations and excitotoxicity in genetically engineered mice in which N-methyl-D-aspartic ..
  78. ncbi Kainate induces rapid redistribution of the actin cytoskeleton in ameboid microglia
    Randolph N Christensen
    Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci Res 84:170-81. 2006
    ..These findings suggest direct microglial excitation via glutamate receptor pathways. Thus, neurotransmitter release after brain or spinal cord injury might directly modulate the inflammatory response...
  79. ncbi Kainic acid induces rapid cell death followed by transiently reduced cell proliferation in the immature granule cell layer of rat organotypic hippocampal slice cultures
    Matthew Paul Sadgrove
    Division of Clinical Neurosciences, Southampton Neurosciences Group, School of Medicine, University of Southampton, Room 6207, Level 6, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, UK
    Brain Res 1035:111-9. 2005
    ..Our results suggest that kainate-induced injury in the early postnatal hippocampus damages precursor cells contributing to a reduction in granule layer cell proliferation...
  80. ncbi Regulation of rat hippocampal neural cadherin in the kainic acid induced seizures
    M Fujita
    Department of Neurosurgery, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, 467 8601, Nagoya, Japan
    Neurosci Lett 297:13-6. 2001
    ..in the hippocampus was examined by in situ hybridization and immunohistochemistry methods in the rat model of kainic acid (KA) induced seizures...
  81. ncbi Magnetic resonance imaging quality and volumes of brain structures from live and postmortem imaging of California sea lions with clinical signs of domoic acid toxicosis
    Eric W Montie
    College of Marine Science, University of South Florida, Florida 33701, USA
    Dis Aquat Organ 91:243-56. 2010
    ..Thus, postmortem MRI scanning (either intact or formalin-fixed) with volumetric analysis can be used to investigate the acute, chronic and possible developmental effects of DA on the brain of California sea lions...
  82. ncbi Uncaria rhynchophylla (miq) Jack plays a role in neuronal protection in kainic acid-treated rats
    Nou Ying Tang
    School of Chinese Medicine, China Medical University, Taichung, Taiwan
    Am J Chin Med 38:251-63. 2010
    ..Our previous studies have shown that UR has both anticonvulsive and free radical-scavenging activities in kainic acid (KA)-treated rats...
  83. ncbi Assessing cortico-hippocampal functional connectivity under anesthesia and kainic acid using generalized partial directed coherence
    Jiannis Taxidis
    School of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK
    Biol Cybern 102:327-40. 2010
    ..cortex (mPFC) and hippocampus and within the hippocampus of the rat brain, under isoflurane anesthesia and kainic acid-induced enhanced neuronal activity...
  84. ncbi Na+/K+-ATPase inhibitor palytoxin enhances vulnerability of cultured cerebellar neurons to domoic acid via sodium-dependent mechanisms
    Anabel Pérez-Gómez
    Departament of Biochemistry and Molecular Biology, Institute of Biotechnlogy of Asturias, University of Oviedo, 33006 Oviedo, Spain
    J Neurochem 114:28-38. 2010
    ..They also raise reasonable concern about possible risks for human health associated to the ingestion of low amounts of phycotoxins PTX and domoic acid in food...
  85. ncbi A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity
    Katrin Sonn
    Protein Laboratory, Department of Neuroscience and Pharmacology, Panum Institute, Copenhagen, Denmark
    J Neurosci Res 88:1074-82. 2010
    ..Here, we demonstrate the neuroprotective effect of EmtinB in the in vitro and in vivo models of kainic acid (KA)-induced neurotoxicity...
  86. ncbi Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466
    Brita Fritsch
    Epilepsy Research Section, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Epilepsia 51:108-17. 2010
    ..We assessed the ability of the noncompetitive AMPA receptor antagonist GYKI 52466 to protect against kainic acid-induced status epilepticus in mice.
  87. ncbi Age-dependent reduction of gamma oscillations in the mouse hippocampus in vitro
    M Vreugdenhil
    Department of Neurophysiology, Division of Neuroscience, School of Medicine, University of Birmingham, West Midlands, UK
    Neuroscience 132:1151-7. 2005
    ..Other mechanisms, including a change with age in the use-dependent modulation of synaptic strength, should account for the impaired gamma oscillations in the aged hippocampus that may contribute to age-dependent memory impairment...
  88. ncbi Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations
    André Fisahn
    Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:9658-68. 2004
    ....
  89. ncbi Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures
    Eun Ae Jeong
    Department of Anatomy and Neurobiology, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, Gyeongsang National University School of Medicine, Jinju, Gyeongnam, 660 751, Republic of Korea
    Exp Neurol 232:195-202. 2011
    ..Thus, the KD may inhibit neuroinflammation by suppressing a COX-2-dependent pathway via activation of PPARγ by the KD or AA...
  90. ncbi Adiponectin protects hippocampal neurons against kainic acid-induced excitotoxicity
    Byeong Tak Jeon
    Department of Anatomy and Neurobiology, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, Gyeongsang National University School of Medicine, 92 Chilam dong, Jinju, Gyeongnam, 660 751, Republic of Korea
    Brain Res Rev 61:81-8. 2009
    ..this study, we investigated the effects of Ad on cell survival and BBB integrity in the mouse hippocampus after kainic acid (KA) treatment...
  91. ncbi Gastrodia elata modulated activator protein 1 via c-Jun N-terminal kinase signaling pathway in kainic acid-induced epilepsy in rats
    Ching Liang Hsieh
    Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan
    J Ethnopharmacol 109:241-7. 2007
    ..elata is able to reduce epileptic seizures, oxygen free radicals, microglia activation, and apoptosis in kainic acid (KA)-treated rats. Activator protein 1 (AP-1) is involved in modulating the neuronal plasticity and apoptosis...
  92. ncbi Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element
    Andrew D Kraft
    University of Wisconsin, Madison, WI, USA
    J Neurochem 98:1852-65. 2006
    ..These results combine to support a role for Nrf2 in the neural cell defense response of the adult brain...
  93. pmc Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity
    Edward B Lee
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 31:14361-6. 2011
    ..C57BL/6J and adiponectin knock-out mice were fed a high-fat diet, followed by treatment with low doses of kainic acid to induce seizures...
  94. ncbi Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death
    R S Morrison
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle 98195 6470, USA
    J Neurosci 16:1337-45. 1996
    ..Subcutaneous injection of kainic acid, a potent excitotoxin, induced comparable seizures in both wild-type mice (+/+) and mice deficient in p53 (-/-)...
  95. pmc Pharmacologic suppression of oxidative damage and dendritic degeneration following kainic acid-induced excitotoxicity in mouse cerebrum
    Snjezana Zaja-Milatovic
    Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, United States
    Neurotoxicology 29:621-7. 2008
    ..b>Kainic acid (KA, 1 nmol/5 microl) was injected intracerebroventricularly to C57Bl/6 mice...
  96. ncbi Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death
    Ana I Rojo
    Instituto de Investigaciones Biomédicas Alberto Sols UAM CSIC, Departamento de Bioquimica, and Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas CIBERNED, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    Mol Cell Neurosci 39:125-32. 2008
    ..Our findings identify the axis GSK-3beta/Nrf2 as a pharmacological target in prevention of excitotoxic neuronal death...
  97. ncbi Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus
    Ik Hyun Cho
    Ewha Institute of Neuroscience and Department of Neuroscience, Ewha Womans University, Seoul, Republic of Korea
    J Neurosci Res 84:1505-11. 2006
    ..In addition, in passive avoidance tests, KA-induced memory impairment was improved markedly by EP. These results suggest that EP has a therapeutic potential for suppressing KA-induced pathogenesis in the brain...
  98. pmc Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: a kainic acid lesion study in guinea pigs
    Ronald K de Venecia
    Department of Otology and Laryngology, Harvard Medical School, and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 487:345-60. 2005
    ..reflex interneurons in the cochlear nucleus by assaying their regional distribution using focal injections of kainic acid. Our reflex metric was the amount of change in the distortion product otoacoustic emission (at 2f(1)-f(2)) just ..
  99. pmc Synaptic kainate currents reset interneuron firing phase
    Ellen J Yang
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Ave, K426, Bronx, NY 10461, USA
    J Physiol 578:259-73. 2007
    ..These data suggest that KARs are potent modulators of circuit behaviour and their activation alters hippocampal interneuron output...
  100. ncbi Kainate excitotoxicity in organotypic hippocampal slice cultures: evidence for multiple apoptotic pathways
    W Liu
    Department of Pharmacology, School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Brain Res 916:239-48. 2001
    ..Finally, inhibition of caspase-3 activity by z-VAD-fmk only partially protected neurons from KA toxicity, implying that multiple mechanisms may be involved in KA excitotoxicity...
  101. ncbi The role of RNA editing of kainate receptors in synaptic plasticity and seizures
    B Vissel
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Neuron 29:217-27. 2001
    ..Together, these results suggest that GluR6 Q/R site RNA editing may modulate synaptic plasticity and seizure vulnerability...

Research Grants70

  1. Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    Heike Wulff; Fiscal Year: 2012
    ....
  2. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    ..A better understanding of kainate receptor properties is essential in the rational development of novel therapeutic agents targeted at these receptors. ..
  3. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..Finally, the specific project will also help train two graduate students and a postdoctoral fellow. ..
  4. Oxaloacetate's Brain Effects
    Russell H Swerdlow; Fiscal Year: 2013
    ..The second is a 2003 study performed on mice, which found OAA prevented kainic acid-induced seizures, brain mtDNA degradation, and lipid peroxidation...
  5. Astrocyte Function and Temporal Lobe Epilepsy
    JAY ROBERT VARGAS; Fiscal Year: 2010
    ..It is anticipated that this work will reveal new potential therapeutic targets for the treatment of epilepsy. ..
  6. Calcium Signaling in a Model of Temporal Lobe Epilepsy
    Karen S Wilcox; Fiscal Year: 2013
    ..Recently we used the kainic acid (KA) model of TLE to investigate 'reactive'astrocytes in the hippocampus (HC), a brain region known ..
  7. Kainate receptor signaling in striatal synaptic function and plasticity
    John Marshall; Fiscal Year: 2012
    ..While currently 30% of OCD cases are intractable, understanding these biochemical and synaptic abnormalities will lead to treatments that are more effective, specific, and give rise to fewer complications. ..
  8. Mechanism of action of novel GluN2C NMDA receptor potentiators
    Alpa Khatri; Fiscal Year: 2013
    ..The data from this research could potentially be useful for developing new therapies for neurological disorders thought to be associated with aberrant NMDA receptor function such as, schizophrenia, autism, and psychosis. ..
  9. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2012
    ..congenic strains in which MEST QTLs are captured by testing them with chemoconvulsants pentylenetetrazol (PTZ), kainic acid (KA) and pilocarpine (PC)...
  10. The Functional Significance of Conformational States in Glutamatergic Signaling
    CATHERINE LOURDES SALUSSOLIA; Fiscal Year: 2013
    ..Thus, by defining novel aspects of glutamate receptor structure-function my studies will serve to further understand glutamate receptor gating and may lead to novel strategies to treat glutamate-based neurological diseases. ..
  11. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2011
    ..Such studies will identify novel therapeutic targets for the treatment of nicotine dependence and habitual tobacco smoking in humans. ..
  12. The role of Kainate receptors in oligodendrocyte toxicity and EAE
    Geoffrey T Swanson; Fiscal Year: 2010
    ..To test our hypothesis we will utilize newly developed selective pharmacological agents and gene-targeted mice lacking kainate receptor subunits. ..
  13. Glutamate Mediates Platelet Activation through an Ionotropic Glutamate Receptor
    Craig N Morrell; Fiscal Year: 2012
    ..that platelets express ionotropic glutamate receptors, including the AMPA type receptor (AMPAR) and the Kainic Acid (KA) type receptor (KAR)...
  14. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA F BRAGA; Fiscal Year: 2013
    ..Including a section of the particularly vulnerable population, and will result in the development of new compounds that will reduce mortality and morbidity during and after an emergency event involving nerve agents. ..
  15. New Pharmacotherapy for Alcohol and Co-morbid Disorders
    Bankole A Johnson; Fiscal Year: 2013
    ..This project supports NIAAA's mission to develop efficacious medications for the treatment of alcohol and nicotine dependence to prevent morbidity and deaths in society. ..
  16. The role of glucocorticoid signaling in immune cells during excitotoxicity.
    SHAWN SORRELLS; Fiscal Year: 2010
    ..This proposal is designed to measure immune cell-specific effects of GCs during kainic acid-induced excitotoxicity by using previously characterized leukocyte-specific, GR-knockout mice...
  17. GLUTAMATE-GATED CHANNELS IN CENTRAL &PERIPHERAL NEURONS
    James E Huettner; Fiscal Year: 2013
    ..This project analyzes the molecular basis of glutamate receptor modulation by DHA, which is present at high levels in the nervous system and is known to be essential for normal brain function. ..
  18. Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
    Susumu Tomita; Fiscal Year: 2013
    ..Because potential roles of kainate receptors in several neurological diseases including autism, schizophrenia, epilepsy and altered sensory transduction have been proposed, this work will identify novel targets for drug discovery. ..
  19. Cochlear Neurotransmitters
    William F Sewell; Fiscal Year: 2013
    ....
  20. Pathophysiology of dystonia: animal models
    Ellen J Hess; Fiscal Year: 2010
    ..Public health relevance: Dystonia is the third most common movement disorder, but current therapies are largely unsatisfactory. The goal is to understand the pathophysiology of dystonia to direct novel treatments. ..
  21. The role of glutamate receptors in compulsive and perseverative behavior
    Anis Contractor; Fiscal Year: 2013
    ....
  22. Evaluation of Scn8a as a target for the treatment of refractory epilepsy
    CHRISTOPHER DONALD MAKINSON; Fiscal Year: 2013
    ..Seizures that originate in the temporal lobe will be induced by intra-hippocampal injection of kainic acid. Aim 2 will provide important information about the role of Scn8a in preventing epileptogenesis (the process by ..
  23. CHEMICAL ARCHITECTURE OF RETINAL CIRCUITS
    Noga Vardi; Fiscal Year: 2012
    ..abstract_text> ..
  24. Diverse Roles of Adult Dentate Gyrus Neurogenesis
    Helen E Scharfman; Fiscal Year: 2013
    ..Our preliminary data also suggest, remarkably, that adult-born neurons reduce the effects of the convulsant kainic acid. These effects are significant because they would allow adult-born neurons to regulate the role of the DG as a "..
  25. Dynamics of pH Regulation in the Brain
    Mitchell Chesler; Fiscal Year: 2013
    ....
  26. AGE RELATED SEIZURE SUPPRESSION
    Solomon L Moshe; Fiscal Year: 2011
    ..Male and female rats will be used. Methods include induction of SE using kainic acid or pilocarpine, intracranial microinfusions of GABAA agents and seizure testing using flurothyl or ..
  27. Dopaminergic and glutamatergic mechanisms of cocaine addiction: sex differences
    WENDY JEAN LYNCH; Fiscal Year: 2012
    ..These studies will provide a much needed foundation for the development of hormonal, pharmacological, and/or molecular based therapeutics for cocaine abuse, especially in women. ..
  28. Calcium Signaling in Astrocytes
    KAREN S contact WILCOX; Fiscal Year: 2010
    ..population calcium transients are altered in brain slices derived from animals that have been subjected to the kainic acid (KA) model of TLE...
  29. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok K Shetty; Fiscal Year: 2010
    ..video-EEC), and learning and memory analyses in young adult F344 rats undergoing intraperitoneal kainic acid induced acute seizures and hippocampal injury, a model of temporal lobe epilepsy...
  30. Vulnerability of Aging White Matter to Ischemia
    Selva Baltan; Fiscal Year: 2013
    ..Our focus is to define appropriate age-specific therapeutic targets for stroke and other neurodegenerative diseases involving WM. ..
  31. Regulation of glutamate receptors by calcium-dependent protein kinase
    Susumu Tomita; Fiscal Year: 2013
    ..Our proposed studies will provide fundamental knowledge relevant to this question. ..
  32. Mitochondrial Bioenergetics and Epilepsy
    Shane D Rowley; Fiscal Year: 2013
    ..respiration rates in hippocampal synaptosomes isolated from epileptic and rats treated with the chemoconvulsant kainic acid. Different cell types and areas of the hippocampus will be used to further isolate where deficits are occurring...
  33. GABAergic regulation of entorhino-hippocampal excitability in epilepsy.
    Ivan Soltesz; Fiscal Year: 2013
    ..The project will determine whether aberrant inhibitory regulation of the entorhino-hippocampal circuits contributes to the generation of seizures. ..
  34. Cerebellar Neurogensis
    Angelique Bordey; Fiscal Year: 2013
    ....
  35. Rat transcriptome biomarkers for the prediction of temporal lobe epilepsy
    STANISLAV KARSTEN; Fiscal Year: 2009
    ..and Sprague-Dawley rats will be subjected to SE induced by either systemic pilocarpine or intrahippocampal kainic acid during either childhood (postnatal day 35) or adulthood (postnatal day 90)...
  36. Roles of Kainate Receptors in Compulsive-Like Behaviors
    Jian Xu; Fiscal Year: 2013
    ..The use of novel animal models will provide important insight into the roles of kainate receptors in pathogenesis of OCD. ..
  37. Prolonged activation of endogenous opioid analgesia after inflammation
    Gregory Corder; Fiscal Year: 2013
    ..to successfully compete for strong post-doctoral positions and ultimately, a successful career in research science and teaching beginning with a tenure-track position in a strong medical research university environment: ..
  38. Optical Detection of the Pre-seizure State
    Devin K Binder; Fiscal Year: 2013
    ..novel fiberoptic NIRS detection system to a well-established animal model of chronic epilepsy (intrahippocampal kainic acid model)...
  39. Sequencing of glutamatergic pathway genes in alcohol and nicotine co-dependence
    Lingjun Zuo; Fiscal Year: 2012
    ..The expected findings would significantly contribute to the improvement of public health. ..
  40. Excitatory synaptic transmission onto hippocampal interneurons
    MATTHEW E FRERKING; Fiscal Year: 2013
    ..This research will allow us to evaluate the possibility of developing therapeutic strategies to control seizure initiation or propagation by manipulating excitatory transmission onto these interneurons. ..
  41. Role of GluK6 in cerebella circuitry development
    Cathryn L Kubera; Fiscal Year: 2012
    ..Since GluK6 dysfunction may play a role in the etiology of autism spectrum disorders, understanding the role of GluK6 in cerebellum circuitry development is paramount. ..
  42. Function of Basal Synapses at Mammalian Photoreceptors
    Steven H DeVries; Fiscal Year: 2013
    ..Specific experiments will determine the extent to which ground squirrel cones recapture released glutamate and determine the locations of glutamate transporters relative to ribbon release sites. ..
  43. Moderate-throughput screening for anti-epileptogenic drugs.
    Kevin J Staley; Fiscal Year: 2012
    ..In vivo testing will be used to confirm the effects of the most promising agents found in the first stage of screening. ..
  44. Role of COX2 of Neuronal Origin in Blood-Brain Communication after status epilept
    Raymond J Dingledine; Fiscal Year: 2012
    ....
  45. Molecular mechanisms linking early life seizures, autism and intellectual disabil
    Timothy A Benke; Fiscal Year: 2013
    ..These hypotheses cannot be tested in a straightforward fashion in patients. The use of our novel animal model of ELS triggering ID with an autistic phenotype allows these elusive clinical questions to be addressed more directly. ..
  46. Regulation of epileptogenesis by the transcriptional repressor, REST
    Jenny Hsieh; Fiscal Year: 2013
    ..Both genetic and pharmacologic approaches will be used to pursue these aims. Strategies will involve conditional mutations of REST, HDAC2 and G9a, together with selective inhibitors of the REST epigenetic effector enzymes. ..
  47. Biomarkers for epileptogenesis after brain injury
    Kevin J Staley; Fiscal Year: 2013
    ..early electrographic epileptiform activity is a promising predictor of epilepsy after brain injury induced by kainic acid. Here we propose to address critical knowledge gaps regarding electrographic biomarkers of epileptogenesis...
  48. Astrocyte dysfunction in epileptogenesis: the role of adenosine
    Detlev Boison; Fiscal Year: 2013
    ..The model system to address this hypothesis consists of intraamygdaloid application of kainic acid (KA) to initiate epileptogenesis selectively in the CA3 area of the hippocampal formation of mice and to ..
  49. Mossy cell network dysfunction in temporal lobe epilepsy
    Anh Bui; Fiscal Year: 2013
    ..Discerning the role of mossy cells in temporal lobe epilepsy and related cognitive impairments may open doors in the development of novel therapeutical approaches for this disorder. ..
  50. Innate and Adaptive Immunity in Childhood Epilepsy
    Sookyong Koh; Fiscal Year: 2013
    ..a new clinically relevant murine model of prolonged febrile convulsions (FCs) followed by "second hit" kainic acid-induced seizures later in life...
  51. Dopamine modulation of glutamatergic signaling in C. elegans chemosensation
    Michael Y Chao; Fiscal Year: 2013
    ..This organism has a simple and well- characterized nervous system that allows us to examine the role of dopamine from molecular and genetic to neural and behavioral effects. ..
  52. The role of neonatal kainate receptors in developing hippocampal circuits.
    Anis Contractor; Fiscal Year: 2013
    ....
  53. Structural dynamics and function of the glutamate receptor ligand-binding domain
    Albert Y Lau; Fiscal Year: 2013
    ..These proteins have key roles in neurodegenerative and psychiatric diseases. The research will help better understand the action of drugs targeting glutamate receptors. ..
  54. Synaptic Glutamate Receptor Trafficking
    Roger A Nicoll; Fiscal Year: 2013
    ..Indeed, clinically promising AMPAkines exert their effect, in part, by controlling the kinetics of AMPAR gating similar to TARPs. ..
  55. Single Channel Properties and Structure of Glutamate Receptors
    James R Howe; Fiscal Year: 2012
    ..In Aim 2 we will extend and quantify these preliminary studies. ..
  56. Prevention of Temporal Lobe Epilepsy
    James O McNamara; Fiscal Year: 2013
    ..of this peptide;mice will be treated with varying doses and at varying intervals prior to induction of kainic acid-induced SE...
  57. Cerebellar Neuromodulation
    Kamran Khodakhah; Fiscal Year: 2013
    ..The goal of this proposal is to delineate the effects of serotonergic drugs on cerebellar Purkinje cells. ..
  58. Adaptive control of epileptic seizures using a genetically encoded sensor
    Galit Pelled; Fiscal Year: 2013
    ..abstract_text> ..
  59. Role of 4.1 proteins in kainate receptor localization and function
    Geoffrey T Swanson; Fiscal Year: 2013
    ..Understanding the molecular and cellular bases for these processes is an important objective, because KARs represent new therapeutic targets for a number of neuropathologies, including chronic pain, anxiety and epilepsy. ..
  60. OXIDATIVE STRESS IN SEIZURE INDUCED NEURONAL INJURY
    WOLF DIETRICH DETTBARN; Fiscal Year: 1999
    DESCRIPTION:(Adapted from the Investigator's Abstract) Diisopropylphosphorofluoridate (DFP) and kainic acid (KA)-induced excessive stimulation of cholinergic and glutamatergic synapses, and increased production of radical oxygen species (..
  61. PHARMACOLOGY OF FETAL STRIATAL TISSUE TRANSPLANTS
    Andrew Norman; Fiscal Year: 1992
    ..The excitotoxin kainic acid (KA) provides a useful model of Huntington's disease...
  62. Balanced, polyvalent antiglutamatergic action as a novel approach to efficacious
    Anatoly Martynyuk; Fiscal Year: 2009
    ....
  63. Astrocytes and temporal lobe epilepsy
    KAREN WILCOX; Fiscal Year: 2009
    ..Recently our laboratory utilized the kainic acid (KA) model of SE to investigate such `reactive'astrocytes...
  64. Pharmacoresistance in rats with kainate-induced epilepsy
    F Dudek; Fiscal Year: 2005
    ..abstract_text> ..
  65. The Medial Entorhinal Cortex and Temporal Lobe Epilepsy
    KAREN WILCOX; Fiscal Year: 2007
    ..is to determine the role of the medial entorhinal cortex (mEC) in the development of chronic epilepsy in the kainic acid model of TLE...
  66. BEHAVIORAL TOXICITY OF LEAD--A PHARMACOLOGICAL ANALYSIS
    Deborah Cory Slechta; Fiscal Year: 2004
    ..They will further define the comparative roles of NMDA and AMPA/kainate receptors in these projections and their interactions with DA systems, allowing rational behavioral and therapeutic approaches to mesolimbic system dysfunctions. ..
  67. NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATION
    JOSE CAVAZOS; Fiscal Year: 2003
    ..neurons, but we still need to determine whether there is a correlation between the anatomical distribution of Kainic acid induced hyperexcitability in the electrophysiological properties of CA1 pyramidal neurons and the anatomical ..
  68. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2001
    ..The interaction of ethanol with ischemic brain damage could yield important and clinically significant information on the neurotoxic effects of ethanol and the neuropathology of chronic alcohol abuse. ..
  69. Kainate Receptors on Hippocampal Interneurons
    Matthew Frerking; Fiscal Year: 2007
    ..abstract_text> ..
  70. Extracellular Modulation of Metabotropic GluRs
    Julie Saugstad; Fiscal Year: 2005
    ..abstract_text> ..