urine

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Top Publications

  1. pmc Accuracy of urine circulating cathodic antigen (CCA) test for Schistosoma mansoni diagnosis in different settings of Côte d'Ivoire
    Jean T Coulibaly
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1384. 2011
  2. pmc Evaluation of circulating cathodic antigen (CCA) urine-tests for diagnosis of Schistosoma mansoni infection in Cameroon
    Louis Albert Tchuem Tchuenté
    Centre for Schistosomiasis and Parasitology, Yaounde, Cameroon
    PLoS Negl Trop Dis 6:e1758. 2012
  3. pmc The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins
    Jun Adachi
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz, D 82152 Martinsried, Germany
    Genome Biol 7:R80. 2006
  4. pmc Association of residual urine output with mortality, quality of life, and inflammation in incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for End-Stage Renal Disease (CHOICE) Study
    Tariq Shafi
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224 2780, USA
    Am J Kidney Dis 56:348-58. 2010
  5. doi Temporal profiling of human urine VOCs and its potential role under the ruins of collapsed buildings
    Pawel Mochalski
    Breath Research Institute of the Austrian Academy of Sciences, Dornbirn, Austria
    Toxicol Mech Methods 22:502-11. 2012
  6. doi Generation of integration-free neural progenitor cells from cells in human urine
    Lihui Wang
    Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
    Nat Methods 10:84-9. 2013
  7. ncbi Saliva parameters as potential indices of hydration status during acute dehydration
    Neil P Walsh
    School of Sport, Health and Exercise Sciences, University of Wales, Bangor, United Kingdom
    Med Sci Sports Exerc 36:1535-42. 2004
  8. doi An evaluation of urine-CCA strip test and fingerprick blood SEA-ELISA for detection of urinary schistosomiasis in schoolchildren in Zanzibar
    J Russell Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, UK
    Acta Trop 111:64-70. 2009
  9. doi Urine testing as a surveillance tool to monitor the impact of HPV immunization programs
    Kate Cuschieri
    Scottish HPV Reference Laboratory, Directorate of Laboratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    J Med Virol 83:1983-7. 2011
  10. ncbi Monitoring for polyomavirus BK And JC in urine: comparison of quantitative polymerase chain reaction with urine cytology
    Parmjeet Randhawa
    Division of Transplant Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA
    Transplantation 79:984-6. 2005

Detail Information

Publications344 found, 100 shown here

  1. pmc Accuracy of urine circulating cathodic antigen (CCA) test for Schistosoma mansoni diagnosis in different settings of Côte d'Ivoire
    Jean T Coulibaly
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1384. 2011
    Promising results have been reported for a urine circulating cathodic antigen (CCA) test for the diagnosis of Schistosoma mansoni...
  2. pmc Evaluation of circulating cathodic antigen (CCA) urine-tests for diagnosis of Schistosoma mansoni infection in Cameroon
    Louis Albert Tchuem Tchuenté
    Centre for Schistosomiasis and Parasitology, Yaounde, Cameroon
    PLoS Negl Trop Dis 6:e1758. 2012
    ..We evaluated the accuracy of circulating cathodic antigen (CCA) urine-assay as a diagnostic tool of S. mansoni. In comparison, a low sensitive CCA test (CCA-L) was assessed.
  3. pmc The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins
    Jun Adachi
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz, D 82152 Martinsried, Germany
    Genome Biol 7:R80. 2006
    b>Urine is a desirable material for the diagnosis and classification of diseases because of the convenience of its collection in large amounts; however, all of the urinary proteome catalogs currently being generated have limitations in ..
  4. pmc Association of residual urine output with mortality, quality of life, and inflammation in incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for End-Stage Renal Disease (CHOICE) Study
    Tariq Shafi
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224 2780, USA
    Am J Kidney Dis 56:348-58. 2010
    ..b>Urine output may provide an estimate of RKF...
  5. doi Temporal profiling of human urine VOCs and its potential role under the ruins of collapsed buildings
    Pawel Mochalski
    Breath Research Institute of the Austrian Academy of Sciences, Dornbirn, Austria
    Toxicol Mech Methods 22:502-11. 2012
    The scent profile of human urine was investigated as potential source of chemical markers of human presence in collapsed buildings after natural or man-made disasters.
  6. doi Generation of integration-free neural progenitor cells from cells in human urine
    Lihui Wang
    Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
    Nat Methods 10:84-9. 2013
    ..reprogramming factors with a chemically defined culture medium to reprogram epithelial-like cells from human urine into NPCs (hUiNPCs)...
  7. ncbi Saliva parameters as potential indices of hydration status during acute dehydration
    Neil P Walsh
    School of Sport, Health and Exercise Sciences, University of Wales, Bangor, United Kingdom
    Med Sci Sports Exerc 36:1535-42. 2004
    ..Secondly, we compared the sensitivity of saliva parameters to track hydration changes with the sensitivity of urine osmolality...
  8. doi An evaluation of urine-CCA strip test and fingerprick blood SEA-ELISA for detection of urinary schistosomiasis in schoolchildren in Zanzibar
    J Russell Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, UK
    Acta Trop 111:64-70. 2009
    ..of urinary schistosomiasis during ongoing control interventions, two commercially available diagnostic tests - the urine-circulating cathodic antigen (CCA) strip and the soluble egg antigen enzyme-linked immunosorbent assay (SEA-ELISA) ..
  9. doi Urine testing as a surveillance tool to monitor the impact of HPV immunization programs
    Kate Cuschieri
    Scottish HPV Reference Laboratory, Directorate of Laboratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    J Med Virol 83:1983-7. 2011
    ..This study was designed to evaluate the performance of HPV testing in urine to assess its suitability for epidemiological and surveillance purposes...
  10. ncbi Monitoring for polyomavirus BK And JC in urine: comparison of quantitative polymerase chain reaction with urine cytology
    Parmjeet Randhawa
    Division of Transplant Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA
    Transplantation 79:984-6. 2005
    ..the relative efficacy of exfoliative cytology and polymerase chain reaction (PCR) for detecting viruria in 100 urine samples. Definite decoy cells were seen in 8% and probable decoy cells in 5% of specimens...
  11. doi Urine for the diagnosis of tuberculosis: current approaches, clinical applicability, and new developments
    Jonathan Peter
    Lung Infection and Immunity Unit, Division of Pulmonology and Clinical Immunology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Curr Opin Pulm Med 16:262-70. 2010
    b>Urine is increasingly being investigated as a convenient clinical sample for the identification of mycobacterial products for the diagnosis of tuberculosis...
  12. doi Urine in clinical proteomics
    Stephane Decramer
    INSERM, U858 I2MR, Department of Cardiac and Renal Remodeling, Team 5, 1 avenue Jean Poulhes, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Cell Proteomics 7:1850-62. 2008
    b>Urine has become one of the most attractive biofluids in clinical proteomics as it can be obtained non-invasively in large quantities and is stable compared with other biofluids...
  13. ncbi Human hydration indices: acute and longitudinal reference values
    Lawrence E Armstrong
    Human Performance Laboratory, University of Connecticut, Storrs, CT, USA
    Int J Sport Nutr Exerc Metab 20:145-53. 2010
    ..1 L/24 hr (range 1.382-3.261, 95% confidence interval 0.970-3.778 L/24 hr); mean urine volume was >1.3 L/24 hr (0.875-2.250 and 0.675-3.000 L/24 hr); mean urine specific gravity was >1.018 (1...
  14. doi PCA3: a molecular urine assay for predicting prostate biopsy outcome
    Ina L Deras
    Gen Probe, Inc, San Diego, California 92121, USA
    J Urol 179:1587-92. 2008
    ..We further characterized PCA3 performance in different groups of men and determined whether the PCA3 score could synergize with other clinical information to predict biopsy outcome...
  15. pmc Identification of a third human polyomavirus
    Tobias Allander
    Laboratory for Clinical Microbiology, Department of Clinical Microbiology, Tumor and Cell Biology, L2 02, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    J Virol 81:4130-6. 2007
    ..5%) of 192 fecal samples but was not detected in sets of urine and blood samples...
  16. pmc Diagnostic accuracy of a urine lipoarabinomannan test for tuberculosis in hospitalized patients in a High HIV prevalence setting
    Maunank Shah
    Department of Medicine, Johns Hopkins University Center for Tuberculosis Research, Baltimore, MD 21231, USA
    J Acquir Immune Defic Syndr 52:145-51. 2009
    Effective tuberculosis (TB) control in HIV-prevalent settings is hindered by absence of accurate, rapid TB diagnostic tests. We evaluated the accuracy of a urine lipoarabinomannan (LAM) test for TB diagnosis in South Africa.
  17. pmc Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    BMC Infect Dis 12:47. 2012
    ..However, the LAM-ELISA assay has demonstrated variable sensitivity in diagnosing TB in diverse clinical populations. We therefore explored pathogen and host factors potentially impacting LAM detection...
  18. doi Global metabolic profiling procedures for urine using UPLC-MS
    Elizabeth J Want
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    Nat Protoc 5:1005-18. 2010
    ..The use of UPLC-MS for metabolic profiling in this way is not faster than the conventional HPLC-based methods but, because of improved chromatographic performance, provides superior metabolome coverage...
  19. pmc Conditionally immortalized human podocyte cell lines established from urine
    Toru Sakairi
    Kidney Disease Section, Kidney Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Am J Physiol Renal Physiol 298:F557-67. 2010
    Evidence suggests that loss of podocytes into urine contributes to development of glomerular diseases; shed podocytes are frequently viable and proliferate in culture conditions...
  20. pmc Comparison of self-collected vaginal, vulvar and urine samples with physician-collected cervical samples for human papillomavirus testing to detect high-grade squamous intraepithelial lesions
    J W Sellors
    Health Services Delivery Research Unit, Father Sean O Sullivan Research Centre, St Joseph s Hospital, Hamilton, Ont
    CMAJ 163:513-8. 2000
    ..We determined and compared the test characteristics of testing for HPV with samples obtained by patients and with samples obtained by their physicians...
  21. doi Excretion of West Nile virus in urine during acute infection
    Luisa Barzon
    Department of Molecular Medicine, University of Padova, Padova, Italy
    J Infect Dis 208:1086-92. 2013
    Detection of West Nile virus (WNV) RNA in urine has been anecdotally described and proposed for the diagnosis of WNV infection...
  22. pmc Optimized siRNA-PEG conjugates for extended blood circulation and reduced urine excretion in mice
    Frank Iversen
    Interdisciplinary Nanoscience Center iNANO and Department of Molecular Biology and Genetics, C F Møllers Alle, Building 1130, 8000 Aarhus C, Aarhus University, Aarhus, Denmark
    Theranostics 3:201-9. 2013
    ..fluorescent imaging of the living animal showed increased concentration of siRNA in peripheral tissue and delayed urine excretion when coupled to PEG 20k...
  23. doi Detection of human papillomavirus DNA in urine. A review of the literature
    A Vorsters
    Centre for Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Faculty of Medicine, Campus Drie Eiken, Universiteitsplein 1, 2610, Antwerpen, Belgium
    Eur J Clin Microbiol Infect Dis 31:627-40. 2012
    The detection of human papillomavirus (HPV) DNA in urine, a specimen easily obtained by a non-invasive self-sampling method, has been the subject of a considerable number of studies...
  24. ncbi Heavy schistosomiasis associated with poor short-term memory and slower reaction times in Tanzanian schoolchildren
    M C H Jukes
    Department of Infectious Disease Epidemiology, Imperial College School of Medicine, London, UK
    Trop Med Int Health 7:104-17. 2002
    ....
  25. pmc Prion disease detection, PMCA kinetics, and IgG in urine from sheep naturally/experimentally infected with scrapie and deer with preclinical/clinical chronic wasting disease
    Richard Rubenstein
    SUNY Downstate Medical Center, Department of Neurology, Box 1213, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Virol 85:9031-8. 2011
    ..agent and limited, infrequent success of disease transmissibility and PrP(Sc) detection have been reported with urine from experimentally infected clinical cervids and rodents...
  26. pmc The microbial communities in male first catch urine are highly similar to those in paired urethral swab specimens
    Qunfeng Dong
    Department of Biology, University of North Texas, Denton, Texas, United States of America
    PLoS ONE 6:e19709. 2011
    b>Urine is the CDC-recommended specimen for STI testing. It was unknown if the bacterial communities (microbiomes) in urine reflected those in the distal male urethra...
  27. pmc Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection
    David E Nelson
    Department of Biology, Indiana University, Bloomington, Indiana, USA
    PLoS ONE 5:e14116. 2010
    ....
  28. pmc Comparative genomic analysis of pathogenic and probiotic Enterococcus faecalis isolates, and their transcriptional responses to growth in human urine
    Heidi C Vebø
    Laboratory of Microbial Gene Technology and Food Microbiology, Department of Chemistry, Biotechnology and Food Science, The Norwegian University of Life Sciences, As, Norway
    PLoS ONE 5:e12489. 2010
    ..have performed comparative genomic analysis, and investigated growth capacity and transcriptome profiling in human urine in vitro. Six strains of different origins were cultivated and all grew readily in human urine...
  29. doi Impact of quinolone restriction on resistance patterns of Escherichia coli isolated from urine by culture in a community setting
    Bat Sheva Gottesman
    Infectious Diseases Unit, Meir Medical Center, Kfar Saba, Israel
    Clin Infect Dis 49:869-75. 2009
    ..Restoration of susceptibility once antimicrobial use is decreased is not self-evident. Our objective was to evaluate, in a community setting, the impact of quinolone restriction on the antimicrobial resistance of E. coli urine isolates.
  30. ncbi Individual recognition in mice mediated by major urinary proteins
    J L Hurst
    Department of Veterinary Clinical Science and Animal Husbandry, University of Liverpool, Leahurst, Neston CH64 7TE, UK
    Nature 414:631-4. 2001
    ..However, rodent urine also contains a class of proteins, termed major urinary proteins (MUPs), that bind and release small volatile ..
  31. ncbi Whole-cell response characteristics of ciliated and microvillous olfactory receptor neurons to amino acids, pheromone candidates and urine in rainbow trout
    K Sato
    Animal Behavior and Intelligence, Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan
    Chem Senses 26:1145-56. 2001
    ..20 beta-dihydroxy-4-pregnen-3-one and ECG; etiocholan-3 alpha-ol-17-one glucuronide), prostaglandins (PGFs) and urine samples collected from immature and mature female fish were applied focally to olfactory cilia or microvilli using ..
  32. ncbi Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
    Hassan Rahmoune
    Clinical Pharmacology Unit, GlaxoSmithKline, Translational Medicine and Technology, Human Biomarkers Centre, Addenbrooke s Hospital, Cambridge, CB2 2GG, UK
    Diabetes 54:3427-34. 2005
    ..isolation and novel primary culture of human exfoliated proximal tubular epithelial cells (HEPTECs) from fresh urine. The primary isolates are highly enriched and differentiated and express characteristic proximal tubular ..
  33. pmc Point-of-care detection of lipoarabinomannan (LAM) in urine for diagnosis of HIV-associated tuberculosis: a state of the art review
    Stephen D Lawn
    University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 12:103. 2012
    Detection of Mycobacterium tuberculosis antigens in urine is attractive as a potential means of diagnosing tuberculosis (TB) regardless of the anatomical site of disease...
  34. doi Human papillomavirus genotype detection and viral load in paired genital and urine samples from both females and males
    Sara L Bissett
    Virus Reference Department, Centre for Infections, Health Protection Agency, London, United Kingdom
    J Med Virol 83:1744-51. 2011
    ..Type-specific detection concordance between paired urine and genital samples from females (n = 264) undergoing routine colposcopy and males (n = 88) attending a ..
  35. pmc Changes in gene cassettes of class 1 integrons among Escherichia coli isolates from urine specimens collected in Korea during the last two decades
    Hak Sun Yu
    Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, 700 422, Korea
    J Clin Microbiol 41:5429-33. 2003
    Gene cassettes of class 1 integrons in Escherichia coli isolates from urine specimens collected in Korea during the last 2 decades were characterized...
  36. pmc Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT)
    Zhen Wang
    Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA
    Proteomics 12:329-38. 2012
    ..Nearly, 3280 proteins were identified from nine human urine samples with 31% overlap among nine samples...
  37. doi Up to 50-fold increase in urine viscosity with iso-osmolar contrast media in the rat
    Erdmann Seeliger
    Institute of Vegetative Physiology, Charite Universitatsmedizin Berlin, CCM, Tucholskystr 2, D 10117 Berlin, Germany
    Radiology 256:406-14. 2010
    ....
  38. doi Urine is a highly cytotoxic agent: does it influence stem cell therapies in urology?
    J Adamowicz
    Department of Tissue Engineering, Nicolaus Copernicus University, Bydgoszcz, Poland
    Transplant Proc 44:1439-41. 2012
    ..In this study we examined the influence of urine on bone marrow-derived mesenchymal stem cells (MSC)...
  39. doi Standard operating procedures for pre-analytical handling of blood and urine for metabolomic studies and biobanks
    Patrizia Bernini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biomol NMR 49:231-43. 2011
    1)H NMR metabolic profiling of urine, serum and plasma has been used to monitor the impact of the pre-analytical steps on the sample quality and stability in order to propose standard operating procedures (SOPs) for deposition in ..
  40. pmc Self-renewal and differentiation capacity of urine-derived stem cells after urine preservation for 24 hours
    Ren Lang
    Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People s Republic of China
    PLoS ONE 8:e53980. 2013
    ..The aim of this study was to characterize urine-derived stem cells (USCs) after optimal preservation of urine specimens for up to 24 hours...
  41. pmc Screening of in vivo activated genes in Enterococcus faecalis during insect and mouse infections and growth in urine
    Aurelie Hanin
    Laboratoire de Microbiologie de l Environnement, EA956 USC INRA2017, Universite de Caen, Caen, France
    PLoS ONE 5:e11879. 2010
    ..faecalis V583 derivative strain and tested in the insect model Galleria mellonella, during growth in urine, in a mouse bacteremia and in a mouse peritonitis model...
  42. pmc Urine heme dipsticks are useful in monitoring the impact of praziquantel treatment on Schistosoma haematobium in sentinel communities of Delta State, Nigeria
    Emmanuel Emukah
    The Carter Center, Owerri, Imo State, Nigeria
    Acta Trop 122:126-31. 2012
    ..is highly endemic for infection with Schistosoma haematobium, which most commonly manifests itself with blood in urine. To monitor the impact of annual mass drug administration (MDA) with Praziquantel for S...
  43. doi Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine
    Joana Carrola
    CICECO, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810 193 Aveiro, Portugal
    J Proteome Res 10:221-30. 2011
    ..has been applied, for the first time to our knowledge, to investigate lung cancer metabolic signatures in urine, aiming at assessing the diagnostic potential of this approach and gaining novel insights into lung cancer ..
  44. doi Urine metabolomics
    Aihua Zhang
    National TCM Key Lab of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, and Key Pharmacometabolomics Platform of Chinese Medicines, Heping Road 24, Harbin 150040, China
    Clin Chim Acta 414:65-9. 2012
    ..b>Urine is an ideal bio-medium for disease study because it is readily available, easily obtained and less complex than ..
  45. pmc A new loop-mediated isothermal amplification method for rapid, simple, and sensitive detection of Leptospira spp. in urine
    Nobuo Koizumi
    Department of Bacteriology, National Institute of Infectious Disease, Tokyo, Japan
    J Clin Microbiol 50:2072-4. 2012
    ..in urine. The method enables detection of two leptospiral cells per reaction mixture following boiling of urine specimens...
  46. ncbi Detection of human papillomavirus in urine and cervical swabs from patients with invasive cervical cancer
    Grazyna A Stanczuk
    Department of Obstetrics and Gynaecology, Medical School, University of Zimbabwe, Harare, Zimbabwe
    J Med Virol 71:110-4. 2003
    ..The presence of HPVs in urine and cervical swab samples collected from 43 women who presented with invasive cervical cancer was investigated...
  47. doi High performance of a new PCR-based urine assay for HPV-DNA detection and genotyping
    Elisabetta Tanzi
    Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
    J Med Virol 85:91-8. 2013
    ..However, both methods require the collection of cervical samples. Urine sample is easier and more acceptable to collect and could be helpful in facilitating cervical cancer screening...
  48. pmc Schistosomiasis and soil-transmitted helminths among an adult population in a war affected area, Southern Kordofan state, Sudan
    Alaa Hammad Ali Abou-Zeid
    Public Health Department, Faculty of Medicine, Cairo University, Kasr Al Ainy St, Manial, Cairo, Egypt
    Parasit Vectors 5:133. 2012
    ..Schistosomiasis remains a major health problem at global and national levels, contributing to the vulnerability of the poor people in Sudan. Southern Kordofan is affected by Schistosomiasis but the disease prevalence was unknown...
  49. doi Diagnostic accuracy of urine filtration and dipstick tests for Schistosoma haematobium infection in a lightly infected population of Ghanaian schoolchildren
    Karen C Kosinski
    Department of Civil and Environmental Engineering, Tufts University, Medford, MA 02155, USA
    Acta Trop 118:123-7. 2011
    Two screening methods, reagent dipsticks for hematuria and urine filtration for Schistosoma haematobium eggs, were evaluated for their sensitivity and specificity in diagnosing infection with S...
  50. pmc Pregame urine specific gravity and fluid intake by National Basketball Association players during competition
    Kristin L Osterberg
    Gatorade Sports Science Institute, 617 West Main Street, Barrington, IL 60010, USA
    J Athl Train 44:53-7. 2009
    b>Urine specific gravity (USG) has been used to estimate hydration status in athletes on the field, with increasing levels of hypohydration indicated by higher USG measurements (eg, greater than 1.020)...
  51. pmc Quantitative analysis of a urine-based assay for detection of lipoarabinomannan in patients with tuberculosis
    Maunank Shah
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Microbiol 48:2972-4. 2010
    ..Patients with disseminated TB and/or advanced HIV are target populations for whom urine LAM detection may be particularly useful.
  52. ncbi Urine cytology findings of polyomavirus infections
    Harsharan K Singh
    University of North Carolina at Chapel Hill, USA
    Adv Exp Med Biol 577:201-12. 2006
    ..along the transitional cell layer, resulting in the shedding of viral particles and infected cells into the urine. A morphologic sign of the (re)activation of polyomaviruses is the detection of typical intranuclear viral ..
  53. doi Trichomonas vaginalis: investigation of a novel diagnostic method in urine samples using cysteine proteinase 4 gene and PCR technique
    Mansoureh Vatanshenassan
    Medical Parasitology and Mycology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Exp Parasitol 126:187-90. 2010
    ..Thus the quest for reliable PCR techniques of T. vaginalis in vaginal discharge and urine sample is more importance...
  54. ncbi Combined morphologic and fluorescence in situ hybridization analysis of voided urine samples for the detection and follow-up of bladder cancer in patients with benign urine cytology
    Michal Daniely
    BioView Ltd, Rehovot, Israel
    Cancer 111:517-24. 2007
    ..Patients with bladder cancer are closely followed with periodic cystoscopies and urine cytology analyses due to the significant risk of tumor recurrence...
  55. pmc Comparative effectiveness of aminoglycosides, polymyxin B, and tigecycline for clearance of carbapenem-resistant Klebsiella pneumoniae from urine
    Michael J Satlin
    Department of Medicine, Weill Cornell Medical College, New York, New York 10021, USA
    Antimicrob Agents Chemother 55:5893-9. 2011
    ..Microbiologic clearance was defined as having a follow-up urine culture that did not yield CRKP...
  56. pmc Assessing diversity of the female urine microbiota by high throughput sequencing of 16S rDNA amplicons
    Huma Siddiqui
    Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, P O Box 1066 Blindern, 0316 Oslo, Norway
    BMC Microbiol 11:244. 2011
    b>Urine within the urinary tract is commonly regarded as "sterile" in cultivation terms...
  57. doi Lactobacillus colonization status in infants with urinary tract infection
    Jung Won Lee
    Department of Pediatrics, Hallym University, Kangnam Sacred Heart Hospital, 94 195 Yeongdeungpo dong, Yeongdeungpo gu, Seoul, 150 030, Korea
    Pediatr Nephrol 24:135-9. 2009
    ..urogenital lactobacilli against urinary tract infection (UTI), lactobacillus cultures were performed on stool and urine specimens and periurethral/vaginal swabs of febrile infants who were suspected of having UTI...
  58. pmc Biofilm formation by and antifungal susceptibility of Candida isolates from urine
    N Jain
    Department of Medicine and Microbiology and Immunology, Ullmann 1223, 1300 Morris Park Ave, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Appl Environ Microbiol 73:1697-703. 2007
    ..We determined BF and MIC to antifungals in Candida spp. isolates grown from urine samples of patients and performed a retrospective chart review to examine the correlation with risk factors...
  59. doi Actinobaculum schaalii: a common cause of urinary tract infection in the elderly population. Bacteriological and clinical characteristics
    Hans Linde Nielsen
    Department of Clinical Microbiology, Viborg Hospital, Heibergs Alle 4, Viborg, Denmark
    Scand J Infect Dis 42:43-7. 2010
    ..In these cases, microscopic findings of coccoid rods in wet smears of urine gave rise to clinical suspicion and subsequently to its isolation from urine. Typically only scant growth of A...
  60. doi Urine metabolite analysis offers potential early diagnosis of ovarian and breast cancers
    Carolyn M Slupsky
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Clin Cancer Res 16:5835-41. 2010
    ..Metabolomics is a new, rapidly expanding field dedicated to the global study of metabolites in biological systems. In this article metabolomics is applied to find urinary biomarkers for breast and ovarian cancer...
  61. pmc Detection of dengue virus in saliva and urine by real time RT-PCR
    Telma R Poloni
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Ribeirão Preto14040 903, Sao Paulo, Brasil
    Virol J 7:22. 2010
    ..The objective of this study was to analyze the usefulness of urine and saliva samples for early diagnosis of DENV infection by real time RT-PCR...
  62. pmc Use of an adaptation of a commercially available PCR assay aimed at diagnosis of chlamydia and gonorrhea to detect Trichomonas vaginalis in urogenital specimens
    Barbara Van Der Pol
    Division of Infectious Diseases, Indiana University Scool of Medicine, Indianapolis, IN 46202, USA
    J Clin Microbiol 44:366-73. 2006
    ..Evaluations included three primer sets, endocervical swabs, vaginal swabs and urine, and various storage conditions...
  63. ncbi Two-dimensional fluorescence difference gel electrophoresis analysis of the urine proteome in human diabetic nephropathy
    Kumar Sharma
    Center for Diabetic Kidney Disease, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proteomics 5:2648-55. 2005
    ..We employed two-dimensional differential in-gel electrophoretic analysis (2-D DIGE) to assess multiple urine samples in patients with diabetic nephropathy. Patient samples were collected as timed overnight collections...
  64. ncbi Exploring the hidden human urinary proteome via ligand library beads
    Annalisa Castagna
    Department of Clinical and Experimental Medicine, Unit of Internal Medicine, University of Verona, Italy
    J Proteome Res 4:1917-30. 2005
    ..In a control urine sample, 134 unique proteins could be identified...
  65. doi Colonization of residents and staff of a long-term-care facility and adjacent acute-care hospital geriatric unit by multiresistant bacteria
    A March
    Reparto di Geriatria, Comprensorio Sanitario di Bolzano, Bolzano, Italy
    Clin Microbiol Infect 16:934-44. 2010
    ..b>Urine samples and rectal, inguinal, oropharyngeal and nasal swabs were plated on chromogenic agar; isolates were typed ..
  66. doi Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering
    Shantaram Bharadwaj
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27101, USA
    Tissue Eng Part A 17:2123-32. 2011
    The goals of this study were to characterize urine-derived stem cells obtained from the upper urinary tract (uUSC), induce these cells to differentiate into urothelial and smooth muscle cells, and determine whether they could serve as a ..
  67. ncbi Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections
    Eliézer K N'goran
    Laboratoire de Biologie Animale, Universite de Cocody, Abidjan, Cote d lvoire
    Am J Trop Med Hyg 68:24-32. 2003
    ..haematobium, done in a highly endemic area of Côte d'Ivoire. Urine specimens from 440 schoolchildren were examined over 4 consecutive days, followed by two systematic praziquantel ..
  68. ncbi MHC class I peptides as chemosensory signals in the vomeronasal organ
    Trese Leinders-Zufall
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 306:1033-7. 2004
    ..MHC peptides constitute a previously unknown family of chemosensory stimuli by which MHC genotypic diversity can influence social behavior...
  69. pmc Evidence of uncultivated bacteria in the adult female bladder
    Alan J Wolfe
    Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA
    J Clin Microbiol 50:1376-83. 2012
    Clinical urine specimens are usually considered to be sterile when they do not yield uropathogens using standard clinical cultivation procedures...
  70. doi A comprehensive and non-prefractionation on the protein level approach for the human urinary proteome: touching phosphorylation in urine
    Qing Run Li
    Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Rapid Commun Mass Spectrom 24:823-32. 2010
    ..However, most of the urine proteomics studies routinely relied on protein pre-fractionation and so far did not present characterization on ..
  71. pmc Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study
    Amy B Howell
    Institut National de la Sante et de la Recherche Medicale, Espri26, Universite Montpellier 1, Nimes, France
    BMC Infect Dis 10:94. 2010
    ..coli adhesion to uroepithelial cells. Additional experiments were required to investigate the persistence in urine samples over a broader time period, to determine the most effective dose per day and to determine if the urinary ..
  72. pmc Adult population as potential reservoir of NTD infections in rural villages of Kwale district, Coastal Kenya: implications for preventive chemotherapy interventions policy
    Sammy M Njenga
    Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute, Mbagathi Road, Nairobi, Kenya
    Parasit Vectors 4:175. 2011
    ..This paper presents the results of a parasitological investigation among adults in the study villages...
  73. ncbi Twenty-four-hour urine chemistries and the risk of kidney stones among women and men
    G C Curhan
    Channing Laboratory, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 59:2290-8. 2001
    Results of a 24-hour urine collection are integral to the selection of the most appropriate intervention to prevent kidney stone recurrence...
  74. doi The ferric yersiniabactin uptake receptor FyuA is required for efficient biofilm formation by urinary tract infectious Escherichia coli in human urine
    Viktoria Hancock
    Microbial Adhesion Group, BioCentrum DTU, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Microbiology 154:167-75. 2008
    ..FyuA was found to be highly important for biofilm formation in iron-poor environments such as human urine. Mutants in fyuA show aberrant biofilm formation and the cells become filamentous; a VR50fyuA mutant showed a 92 % ..
  75. pmc Validation of a new test for Schistosoma haematobium based on detection of Dra1 DNA fragments in urine: evaluation through latent class analysis
    Olufunmilola Ibironke
    Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland, USA
    PLoS Negl Trop Dis 6:e1464. 2012
    ..We evaluated three tests for viable infection: detection of parasite specific DNA Dra1 fragments, haematuria and presence of parasite eggs for sensitivity (Se) and specificity (Sp)...
  76. pmc Characteristics of Candida albicans biofilms grown in a synthetic urine medium
    Priya Uppuluri
    Department of Biology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Clin Microbiol 47:4078-83. 2009
    ..Here, we describe the characterization of C. albicans biofilms formed in vitro using synthetic urine (SU) medium and the frequently used RPMI medium and compare the results. Biofilms of C...
  77. doi Detection of BK, JC, WU, or KI polyomaviruses in faecal, urine, blood, cerebrospinal fluid and respiratory samples
    Seweryn Bialasiewicz
    Queensland Pediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, QLD, Australia
    J Clin Virol 45:249-54. 2009
    ..The related human polyomaviruses JCV and BKV in contrast, have been detected in a wide range of sample types, leading to increased knowledge about their biology and pathogenesis...
  78. ncbi Apical cell membranes are shed into urine from injured podocytes: a novel phenomenon of podocyte injury
    Masanori Hara
    Department of Pediatrics, Yoshida Hospital, Yoshida machi, Nishikanbara gun, 959 0242 Niigata, Japan
    J Am Soc Nephrol 16:408-16. 2005
    Previously it was shown that urine from patients with nephritis contains podocytes and their fragments (podocalyxin [PCX]-positive granular structures [PPGS]), reflecting the degree of podocyte injury...
  79. ncbi Standardized peptidome profiling of human urine by magnetic bead separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Georg Martin Fiedler
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Leipzig, Germany
    Clin Chem 53:421-8. 2007
    Peptidome profiling of human urine is a promising tool to identify novel disease-associated biomarkers; however, a wide range of preanalytical variables influence the results of peptidome analysis...
  80. doi Metabolic profiling of accelerated aging ERCC1 d/- mice
    Ekaterina Nevedomskaya
    Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Proteome Res 9:3680-7. 2010
    ..In the current study, we have performed metabolic profiling of serum and urine of these mice in comparison to wild type and in relation to aging by (1)H NMR spectroscopy...
  81. ncbi Laboratory diagnosis of urinary tract infections in adult patients
    Michael L Wilson
    Department of Pathology and Laboratory Services, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado 80204 4507, USA
    Clin Infect Dis 38:1150-8. 2004
    ..Among the diagnostic tests, urinalysis is useful mainly for excluding bacteriuria. Urine culture may not be necessary as part of the evaluation of outpatients with uncomplicated UTIs, but it is necessary ..
  82. doi Detection and quantification of leptospires in urine of dogs: a maintenance host for the zoonotic disease leptospirosis
    P Rojas
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    Eur J Clin Microbiol Infect Dis 29:1305-9. 2010
    ..Maintenance hosts typically remain clinically asymptomatic and shed leptospires into the environment via urine. In contrast, accidental hosts such as humans can suffer severe acute forms of the disease...
  83. ncbi Responses of vomeronasal neurons to natural stimuli
    T E Holy
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 289:1569-72. 2000
    ..These cells responded to components of urine by increasing their firing rate. This chemosensory activation required phospholipase C function...
  84. pmc Mutational and transcriptional analyses of an avian pathogenic Escherichia coli ColV plasmid
    Jerod A Skyberg
    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    BMC Microbiol 8:24. 2008
    ..coli to kill avian embryos, grow in human urine, and colonize the murine kidney...
  85. doi Direct identification of bacteria causing urinary tract infections by combining matrix-assisted laser desorption ionization-time of flight mass spectrometry with UF-1000i urine flow cytometry
    X H Wang
    The Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, People s Republic of China
    J Microbiol Methods 92:231-5. 2013
    ..matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) combined with UF-1000i urine flow cytometry of urine specimens to quickly and accurately identify bacteria causing UTIs...
  86. ncbi Structure of Proteus mirabilis biofilms grown in artificial urine and standard laboratory media
    Steven M Jones
    Calgary Centre for Innovation and Technology, University of Calgary, Calgary, Alberta, Canada
    FEMS Microbiol Lett 268:16-21. 2007
    ..Therefore, a comparison of biofilm structure in artificial urine (AU) and laboratory media was undertaken. We compared the structure of P...
  87. pmc On-chip imaging of Schistosoma haematobium eggs in urine for diagnosis by computer vision
    Ewert Linder
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    PLoS Negl Trop Dis 7:e2547. 2013
    ..Images can be transferred for analysis both visually and by computer vision both at point-of-care and at remote locations...
  88. doi Non-invasive urine based tests for the detection of bladder cancer
    Neha Wadhwa
    School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, State Technological University of Madhya Pradesh, Bhopal, Madhya Pradesh
    J Clin Pathol 65:970-5. 2012
    ..Therefore, the development of non-invasive urine based tests for the early detection of bladder cancer would be of tremendous benefit to both patients and ..
  89. doi Longitudinal relationships between fluid status, inflammation, urine volume and plasma metabolites of icodextrin in patients randomized to glucose or icodextrin for the long exchange
    Simon J Davies
    Department of Nephrology, North Staffordshire Hospital, Princes Road, Hartshill, Stoke on Trent, ST4 7LN, UK
    Nephrol Dial Transplant 23:2982-8. 2008
    ....
  90. pmc Measuring morbidity associated with urinary schistosomiasis: assessing levels of excreted urine albumin and urinary tract pathologies
    José C Sousa-Figueiredo
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, UK
    PLoS Negl Trop Dis 3:e526. 2009
    ..We therefore aimed to determine associations between excreted urine-albumin, as measured using a HemoCue photometer, and UTPs, as detected by ultrasonography, in children and adults ..
  91. pmc Mapping the cytokine profile of painful bladder syndrome/interstitial cystitis in human bladder and urine specimens
    Anthony T Corcoran
    Department of Urology, University of Pittsburgh School of Medicine, Suite 700 Kaufmann Medical Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    World J Urol 31:241-6. 2013
    This study investigated the cytokine profile in bladder tissue and urine of painful bladder syndrome/interstitial cystitis (PBS/IC) patients.
  92. pmc Major uropathogenic Escherichia coli strain isolated in the northwest of England identified by multilocus sequence typing
    Siu Ha Lau
    Department of Medical Microbiology, School of Medicine, University of Manchester, Clinical Sciences Building 1, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
    J Clin Microbiol 46:1076-80. 2008
    A total of 88 uropathogenic Escherichia coli isolates, including 68 isolates from urine and 20 isolates from blood, were characterized by multilocus sequence typing (MLST). MLST has identified an important genetic lineage of E...
  93. ncbi Accuracy of urine specific gravity and osmolality as indicators of hydration status
    Robert A Oppliger
    Iowa Wrestling Research, Iowa City, IA 52240, USA
    Int J Sport Nutr Exerc Metab 15:236-51. 2005
    ..This investigation: 1) compared sensitivity of urine specific gravity (Usg), urine osmolality (U(osm)) and a criterion measurement of hydration, plasma osmolality (P(..
  94. doi Nasopharyngeal carriage of Streptococcus pneumoniae and pneumococcal urine antigen test in healthy elderly subjects
    Arto A Palmu
    National Institute for Health and Welfare, Helsinki, Finland
    Scand J Infect Dis 44:433-8. 2012
    ..Lower carriage rates have been reported in adults and only sparse data are available for the elderly. We sampled healthy elderly subjects for nasopharyngeal carriage to assess the prevalence of pneumococcal carriage using various assays...
  95. ncbi Comparison of NMP22 BladderChek test and urine cytology for the detection of recurrent bladder cancer
    Atul Kumar
    Department of Urology, All India Institute of Medical Sciences, New Delhi, India
    Jpn J Clin Oncol 36:172-5. 2006
    ..the clinical performance of the NMP22 BladderChek test, which is a qualitative test, and to compare it with voided urine cytology for the detection of recurrent bladder cancer...
  96. doi Day of surgery urine cultures identify urogynecologic patients at increased risk for postoperative urinary tract infection
    Cynthia S Fok
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Urology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA
    J Urol 189:1721-4. 2013
    ..In this study we assess the proportion of urogynecologic patients with a positive day of surgery urine culture, the clinical consequences of a positive day of surgery culture and differences in postoperative urinary ..
  97. doi Biofilm formation with mixed cultures of Pseudomonas aeruginosa/Escherichia coli on silicone using artificial urine to mimic urinary catheters
    Laura Cerqueira
    Centre of Biological Engineering, IBB Institute for Biotechnology and Bioengineering, University of Minho, Braga, Portugal
    Biofouling 29:829-40. 2013
    ..common bacteria associated with urinary tract infections, were formed in silicon coupons immersed in artificial urine medium. In single species experiments, E. coli appeared to form biofilms more easily than P. aeruginosa...
  98. doi Evaluation of diagnostic strategies for bladder cancer using computed tomography (CT) urography, flexible cystoscopy and voided urine cytology: results for 778 patients from a hospital haematuria clinic
    Christopher G T Blick
    Department of Urology, The Churchill Hospital, Oxford, UK
    BJU Int 110:84-94. 2012
    ..The present study also shows that the diagnostic accuracy of voided urine cytology is too low to justify its continuing use in a haematuria clinic using CT urography and flexible cystoscopy...
  99. doi Methodological aspects for metabolome visualization and characterization: a metabolomic evaluation of the 24 h evolution of human urine after cocoa powder consumption
    R Llorach-Asunción
    Nutrition and Food Science Department, XaRTA INSA, INGENIO CONSOLIDER program Fun C Food CSD2007 063, Pharmacy Faculty, University of Barcelona, Barcelona, Spain
    J Pharm Biomed Anal 51:373-81. 2010
    ..After overnight fasting, 10 subjects consumed cocoa powder with milk. Urine samples were collected before the ingestion product and at 0-6, 6-12, 12-24 h after test-meal consumption and ..
  100. ncbi Identification of protein pheromones that promote aggressive behaviour
    Pablo Chamero
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92030, USA
    Nature 450:899-902. 2007
    ..Our results substantiate the idea of MUP proteins as pheromone ligands that mediate male-male aggression through the accessory olfactory neural pathway...
  101. doi Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology
    Shantaram Bharadwaj
    Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Stem Cells 31:1840-56. 2013
    We sought to biologically characterize and identify a subpopulation of urine-derived stem cells (USCs) with the capacity for multipotent differentiation...

Research Grants86

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Design: - Participants will be screened with a physical exam, eye exam, and medical history. Blood and urine samples will be taken. - Participants will have at least eight clinic visits during the 64-week study period...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Design: - Participants will be screened with a physical exam, eye exam, and medical history. Blood and urine samples will be taken. - Participants will have at least eight clinic visits during the 64-week study period...
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..non-ablative technology to join and seal tissues for controlling the leakage of blood, gastrointestinal fluids, urine, bile, lymph, and cerebrospinal fluid...
  5. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..Blood and urine have been collected from 30 applicators applying the herbicide 2, 4-D to relate dose to possible biologic effects, ..
  6. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..Blood and urine have been collected from 30 applicators applying the herbicide 2, 4-D to relate dose to possible biologic effects, ..
  7. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..exhaled NO (eNO) and sinus CT score;as well as measurements of cytokines in serum and leukotrienes in urine. Finally teenagers aged 14-16 years will be studied to determine the independent effects of physical activity, ..
  8. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Kidney disease that is identified by the appearance of large amounts of protein in the urine, edema or swelling of tissues, low plasma proteins and increased cholesterol is termed nephrotic syndrome...
  9. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..In addition, we will analyze the plasma and urine glycoproteome, with focus on those glycoproteins serving as inflammatory cell messengers and hormones...
  10. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..stress that can serve as surrogate endpoints in early trials, and c) determine how biomarkers in serum and urine relate to antioxidant levels in the liver itself and to tissue markers of pre-neoplastic change...
  11. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..a high urea concentration in the inner medullary region so that water is absorbed to produce concentrated urine. Mice with one of the UT genes knocked out show reduced ability to absorb water, and genetic variations of human ..
  12. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..In addition to data collected at baseline and follow-up interviews, blood and urine samples were collected from more than 50,000 subjects at baseline and stored in ultra-low temperature condition ..
  13. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    ..of cells inside the bladder to high concentrations of waste products like urea, which are normally present in the urine, can interfere with the ability of the body to recognize and repair damage to its genetic code...
  14. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    ..is an antibacterial protein which is produced in the liver, circulates in the blood, and is excreted in the urine. It is a type II acute phase protein, the expression of which is induced by interleukin (IL)-6, and down-regulated ..
  15. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..high Na diet induces local increases in PG synthesis, specifically prostaglandin E2 (PGE2), which is measurable in urine and kidney. PGE2 is a potent inhibitor of Na and water reabsorption in the inner medullary collecting duct (IMCD)...
  16. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-Lead
    CYNTHIA T MCEVOY; Fiscal Year: 2013
    ..Patients will be monitored with a set of serial biomarkers to assess smoking and medication compliance, including urine cotinines levels, smoking questionnaires, pill counts and fasting plasma ascorbic acid levels...
  17. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..The candidate has recently shown that intraoperative concentrations of plasma and urine markers of oxidant injury (F2-isoprostanes and isofurans) predict the development of postoperative AKI...
  18. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Spirometry, symptoms, sputum, blood, urine, exhaled breath and ultrasonography will be collected on all subjects pre- and post-exposure...
  19. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..a clinical/translational aspect of our hypothesis by conducting a retrospective analysis using banked serum, urine and/or liver biopsy samples from healthy, uninfected individuals and HCV-infected patients (responders and non-..
  20. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
    ..metabolism will be collected throughout the study using participant reports, exhaled carbon monoxide (CO) levels, urine cotinine levels, and plasma nicotine, cotinine, and 3'-hydroxycotinine levels...
  21. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..by assaying tubule physiology, including measurement of transepithelial potential and potassium flux, rates of urine secretion, and lethality of adult flies on high-potassium food, as well as in vitro and cell culture assays of ..
  22. Molecular Basis of E. coli Adhesins in Bladder Disorders
    Scott J Hultgren; Fiscal Year: 2013
    ..There are two bladder associated niches for UPEC during acute UTI: the bladder tissue and the luminal space/urine. FimH, the type 1 pilus adhesin mediates UPEC colonization and invasion of human and murine bladder epithelial ..
  23. Pathogenesis of the Metabolic Syndrome
    W Timothy Garvey; Fiscal Year: 2013
    ..profiles will be assessed for acylcarnitines, fatty acids, organic acids, amino acids, and LCFA-CoAs in plasma, urine, and in biopsied muscle tissue...
  24. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
    ..obtained detailed medical and obstetrical information monthly, and serially collected plasma, serum, DNA, RNA, and urine. Preliminary data suggest that elevated levels of complement activation products antecede and predict poor fetal ..
  25. Autoimmunity Center of Excellence (ACE) at Stanford
    CHARLES GARRISON FATHMAN; Fiscal Year: 2013
    ..a two year research plan in Systemic Juvenile Idiopathic Arthritis (SJIA) patients to identify and validate urine peptide biomarkers that predict (a) response to TNF inhibition;(b) response to IL-1 inhibition;and (c) impending ..
  26. JACKSON HEART STUDY
    Herman Taylor; Fiscal Year: 2010
    ..inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  27. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2013
    ..inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  28. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..methods of isotope-dilution mass spectrometry for the quantitation of aflatoxin biomarkers in liver, blood, urine and feces in order to develop for the first time a comprehensive mass balance for the fate of the ultimate ..
  29. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2011
    ..inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  30. JACKSON HEART STUDY
    Asoka Srinivasan; Fiscal Year: 2010
    ..inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  31. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  32. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  33. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2011
    ..In addition, we will analyze the plasma and urine glycoproteome, with focus on those glycoproteins serving as inflammatory cell messengers and hormones...
  34. Arsenic Exposure, Genetic Determinants and Diabetes Risk in a Family Study
    Ana Navas-Acien; Fiscal Year: 2013
    ..Preliminary studies: We have identified an association between urine arsenic concentrations and the prevalence of diabetes in American Indians 45-74 year old from Arizona, Oklahoma ..
  35. Combined BAC Transgenic and Knock-Out Mouse Model of Lowe Syndrome Nephropathy
    Robert L Nussbaum; Fiscal Year: 2013
    ..Testing these hypotheses is hampered by the lack of a mouse model because mice with a knock-out of Ocrl, the urine homolog of OCRL, have no detectable phenotype...
  36. Citrulline to Prevent or Mitigate Acute Lung Injury in Severe Sepsis
    Todd W Rice; Fiscal Year: 2013
    ..Isoprostanes, isofurans, and nitrotyrosine from urine and breath condensate will be measured as markers of oxidative stress...
  37. Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    ..aims will address the central hypotheses that 1) increased levels of biomarkers (serum zonulin, Lactulose/Mannitol urine ratio, and/or fecal a-1 anti-trypsin) will identify infants with increased intestinal permeability;and 2) oral ..
  38. Abnormal Bladder Epithelial Cell Gene Expression in BPS/IC
    SUSAN F KEAY; Fiscal Year: 2013
    ..that is not secreted by control cells, is found uniquely in urine from approximately 95% of BPS/IC patients (but not in control urine), and which induces the same abnormalities in ..
  39. Role of Endocytosis and Vesicular Trafficking in Podocyte Health and Filter Integ
    Puneet Garg; Fiscal Year: 2012
    ..Glomerular diseases including diabetic nephropathy present with protein leak (proteinuria) in the urine. Several podocyte specific gene mutations including NPHS1 and NPHS2 that result in proteinuric renal diseases have ..
  40. Salivary-based Bone-loss Marker Detection Platform for Point-of-Care Screening
    MANAL BESHAY; Fiscal Year: 2012
    ..tests such as enzyme linked immunoassay (ELISA) kits for the detection of individual biomarkers in either blood or urine are generally not offered for screening and treatment follow-up applications because they are invasive and ..
  41. New Rapid Diagnostic Tests for Amebiasis
    JOEL F HERBEIN; Fiscal Year: 2010
    ..antigen in fecal specimens from patients with amebic colitis, and in serum, whole blood, saliva and urine from patients with extraintestinal amebiasis. Specific Aim #2 highlights production and FDA clearance of the E...
  42. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-DCC
    Cynthia D Morris; Fiscal Year: 2013
    ..Patients will be monitored with a set of serial biomarkers to assess smoking and medication compliance, including urine cotinines levels, smoking questionnaires, pill counts and fasting plasma ascorbic acid levels...
  43. Non-Alcoholic Fatty Liver Disease and Obstructive Sleep Apnea: Mechanistic Links
    SHIKHA SEKSARIA SUNDARAM; Fiscal Year: 2013
    ..Research subjects will undergo testing of blood and urine for evidence of liver injury, metabolic abnormalities, oxidative stress and activation of inflammatory pathways...
  44. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2012
    ..bladder cancer and many potentially protective compounds contained in plant-derived food are concentrated in the urine, it is plausible that bioactive agents in plants may play a role in bladder cancer chemoprevention...
  45. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..To address this gap, existing FDA methodologies must 4 be extended to testing of new matrices such as milk, urine, blood, and tissues...
  46. Clinical and genomic responses to remote ischemic preconditioning
    Brian W McCrindle; Fiscal Year: 2010
    ..These measures will include indices of renal (urine output, urea, creatinine), cardiac (troponin I, inotrope score), pulmonary (pulmonary and airway mechanics, ..
  47. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
    ..Renal clearances are not useful in these conditions because of mixture of urine in the bladder whereas independent catheterization of ureters (split renal function) lead to pyelonephritis...
  48. High affinity capturing agents for strychnine
    Kit S Lam; Fiscal Year: 2011
    ..in the liver by microsomal enzymes and its metabolites are eliminated from the body via the kidney into the urine. Biological half-life in humans is about 10-12 hours. Up to 20% is excreted unchanged in the urine within 24 hours...
  49. NATIONAL CHILDREN'S STUDY - CACHE COUNTY STUDY CENTER
    Edward Clark; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord ..
  50. Human developmental toxicity of metal mixture exposure from e-waste recycling
    Aimin Chen; Fiscal Year: 2010
    ..The applicants will assess the environmental (air, dust, soil) and biological (maternal blood, urine, hair, cord blood) exposure markers of e-waste metal mixtures (Pb, Hg, Cd, Cr, Mn)...
  51. Progression of Autoimmunity During Puberty in SLE
    KATHLEEN M O'NEIL; Fiscal Year: 2011
    ..We will collect clinical data, blood, RNA and urine serially to identify hormones that correlate with increased flare rates...
  52. Masked Hypertension in Chronic Kidney Disease
    Rajiv Agarwal; Fiscal Year: 2013
    ..Target organ damage will be assessed using LV mass and pulse wave velocity by echocardiogram and 24 hour urine for albuminuria. Examinations will be repeated biannually...
  53. A Rapid Point-of-care Diagnostic for C.trachomitis STDs
    RICHARD F contact SELDEN; Fiscal Year: 2010
    ..In the SBIR Phase II, we will: 1) Expand our methods to extract genomic DNA from conjunctival, pharyngeal, urine, ulcer, vaginal and rectal samples;2) Expand our primer design to identify strain types based on comparative ..
  54. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer L Coburn; Fiscal Year: 2010
    ..can serve as carriers, with the Leptospira persisting in the proximal tubules of the kidney and being shed in the urine. The persistence of leptospirosis in wildlife, companion animals, livestock, and in particular peridomestic rats, ..
  55. Biomarker Reference Laboratory, EDRN
    William E Grizzle; Fiscal Year: 2010
    ..UAB worked in the design and protocol development of the validation study of using microsatellite analysis of urine sediment in the early detection of transitional cell carcinoma of the bladder and as the primary validation ..
  56. Central Biochemistry Laboratory of the CKiD Consortium
    George J Schwartz; Fiscal Year: 2013
    ..required for performing iohexol-based glomerular filtration rate (GFR) studies and collecting blood and urine for analysis at URMC and other laboratories...
  57. ORGANOPHOSPHATE PESTICIDES AND HUMAN REPRODUCTIVE HEALTH
    Xiping Xu; Fiscal Year: 2003
    ..Each woman will keep a diary of her menstrual information, environmental exposures, and dietary intake. Daily urine samples will be collected from each female subject for up to one year or until a pregnancy occurs...
  58. Signal transduction in TRPM5-expressing olfactory sensory neurons
    Diego Restrepo; Fiscal Year: 2010
    ..Interestingly, TRPM5-expressing OSNs project to urine- and pheromone-responsive areas in the ventral olfactory bulb...
  59. Point-of-Care Diagnostic Assay for Direct Detection of Pathogenic Leptospira
    Jeffrey Smith; Fiscal Year: 2010
    ..Leptospirosis is contracted through skin or mucous membrane contact with urine of infected animals. Most often this occurs by contact with contaminated bodies of water or soil...
  60. Virus Electrodes for Fungal Pathogen Detection
    Gary Fujii; Fiscal Year: 2009
    ..Therefore, a technology that reliably measures the presence of these markers in the blood or urine on a real-time basis could have a major impact on the early detection and diagnosis of infectious diseases, such ..
  61. Omega 3 Fatty Acid Supplementation in Diabetic Kidney Disease
    EDGAR RAYMOND MILLER; Fiscal Year: 2010
    ..plans for a randomized controlled clinical trial to determine the effects of omega-3 fatty acid supplementation on urine protein excretion in adults with diabetes and kidney disease defined by the presence proteinuria...
  62. Arrayed Lateral Flow Biosensor for Rapid Molecular Identification of UTI-Related
    Anjal C Sharma; Fiscal Year: 2012
    ..5 billion ($1 billion for men;$2.5 billion for women) in year 2000. Because UTI is so common, large numbers of urine specimens are processed daily in most clinical microbiology laboratories and this comprises a significant ..
  63. Rapid Point-of-Care Test Kit for the Detection of Bacteriuria Calibrated for Imme
    MARK GEISBERG; Fiscal Year: 2010
    ..While bacteriuria at a level of 105 CFU/ml is the gold standard for UTI diagnosis, in practice the required urine culture is unfeasible due to the typical 2-day delay in obtaining results...
  64. Clinical Response to Biomarker Documentation of Child Secondhand Smoke Exposure
    ANNE JOSEPH; Fiscal Year: 2010
    ..and reports levels of tobacco toxicants (tobacco-specific carcinogens, nicotine and cotinine) found in the urine of children exposed to SHS will 1) increase provider delivery of tobacco treatment, 2) increase parental ..
  65. SERUM OSTEOCLASTIC ACID PHOSPHATASE IMMUNOASSAY
    KIN HING LAU; Fiscal Year: 1993
    DESCRIPTION (Adapted from the applicant's abstract): A convenient, sensitive, and accurate blood or urine test for bone resorption is needed for rapid diagnoses and close monitoring of the effectiveness of treatments of metabolic bone ..
  66. Glycosaminoglycans For IC Pathophysiology and Prognosis
    Vinata Lokeshwar; Fiscal Year: 2005
    ..Since the luminal glycosaminoglycan (GAG) layer protects the bladder urothelium from noxious substances in urine, alterations in urothelial GAGs may be associated with IC pathophysiology. Urinary levels of total (i.e...
  67. Prenatal Bisphenol A and Sexually Dimorphic Neurodevelopment
    Bernard Weiss; Fiscal Year: 2010
    ..2) It measures exposure biomarkers in both species (in urine, blood, or both). (3) It encompasses several behavioral endpoints, including cognitive function...
  68. Field-Deployable Monitor to Assess Personal Exposure to Multiple Heavy Metals
    BADAWI M DWEIK; Fiscal Year: 2010
    ..Trace metals can be measured in human tissue or fluids such as blood or urine in centralized laboratories using complex analytical methods such as high-performance liquid chromatography ..
  69. Quantitative Mass Spectrometry Assays to Detect Multiple Myeloma and Assess Relap
    JOHN MATTHEW KOOMEN; Fiscal Year: 2010
    ..and distribution, assays can be developed to quantify protein biomarkers from complex mixtures, such as blood or urine. The development of these assays relies on selective detection of specific peptides, which are enzymatically ..
  70. Proximal Prostate Fluids for Protein and miRNA Biomarkers
    Richard R Drake; Fiscal Year: 2010
    ..secreted by the prostate following a digital rectal prostate massage, which in turn can be collected in voided urine post-exam...
  71. Translational approaches to multilevel models of prenatal exposure to cigarettes
    Vanja Dukic; Fiscal Year: 2010
    ..exposure to cigarettes frequently acquire both self- report and biologic assays (such as cotinine levels in urine or blood) of maternal smoking...
  72. Development of a Urine Test for the Early Detection of Colon Cancer
    Wei Song; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Our overall goal is to develop a urine DNA-based screening test for the early detection of colorectal cancer (CRC) that is noninvasive, patient-friendly, and more sensitive than existing noninvasive ..
  73. MYELIN BASIC PROTEIN PEPTIDES IN BODY FLUIDS
    JOHN WHITAKER; Fiscal Year: 1993
    ..myelin basic protein originating from damaged central nervous system myelin enter cerebrospinal fluid, blood and urine of persons with multiple sclerosis and that measurement of these peptides offers a means of monitoring of tissue ..
  74. Profiling Urine Glycosylation of PSA and other Glyco-Biomarkers in Prostate Cance
    Lewis Pannell; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Urine represents an easily available yet largely discarded potential source of biomarkers of urogenital cancers. Biomarkers of cancer appear in urine, even from remote cancers such as lung and breast...
  75. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..specimens collected in the antenatal period; 2) Evaluate the correlation between amniotic fluid and maternal urine BPA concentration; and the reproducibility of maternal urine BPA concentration over the course of pregnancy; and 3)..
  76. EPITHELIAL OXALATE AND CITRATE TRANSPORT
    DAVID BRUCE MOUNT; Fiscal Year: 2011
    Oxalate is excreted in the urine via a combination of both glomerular filtration and proximal tubular secretion...
  77. Elastic biodegradable ureteral stent
    Haesun Park; Fiscal Year: 2009
    ..The ureter is a tube that allows urine to flow from the kidney to the bladder...
  78. AIDS DEMONSTATION--THREE LEVELS OF METHADONE MAINTENANCE
    ANNA CHILDRESS; Fiscal Year: 1990
    ..elimination of a minimum counselor- patient ratio requirement (now 1 to 50) and the reduction in the number of urine specimens required by methadone maintenance programs (now 1 per month)...
  79. Urinary peptide excretion and onset of puberty
    Stephen Barnes; Fiscal Year: 2009
    ..The study will utilize urine and blood samples collected previously from girls between the ages of 10-13 in an NCI-funded U54 observational ..
  80. INTER ALPHA TRYPSIN INHIBITOR IN CAOX UROLITHIASIS
    Susan Ruth Marengo; Fiscal Year: 2002
    Using samples from 101 volunteers and Western blot analysis of spot and 24 hr urine specimens, we have demonstrated that males who are confirmed active calcium oxalate (CaOx) stone formers (SF) typically expressed inter-alpha-trypsin ..