Genomes and Genes
Summary: The fluid inside CELLS.
Publications227 found, 100 shown here
- Separation and characterization of currents through store-operated CRAC channels and Mg2+-inhibited cation (MIC) channelsMurali Prakriya
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Gen Physiol 119:487-507. 2002....
- The extracellular fluid-to-intracellular fluid volume ratio is associated with large-artery structure and function in hemodialysis patientsYao Ping Lin
Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
Am J Kidney Dis 42:990-9. 2003..It is not clear how body fluid distribution affects large-artery structure and function in patients with ESRD...
- Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neuronsJohn M Power
Division of Neuroscience, John Curtin School for Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Neurosci 22:3454-62. 2002..Because rises in nuclear calcium are known to initiate the transcription of novel genes, we suggest that these actions of cholinergic stimulation may underlie its effects on learning and memory...
- Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathwaysPhilipp Henneke
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 169:3970-7. 2002..We conclude that the inflammatory, bactericidal, and phagocytic responses to GBS occur via parallel but independent processes...
- Intracellular Ca2+ signals evoked by stimulation of nicotinic acetylcholine receptors in SH-SY5Y cells: contribution of voltage-operated Ca2+ channels and Ca2+ storesFederico A Dajas-Bailador
Department of Biology and Biochemistry, University of Bath, Bath, UK
J Neurochem 81:606-14. 2002..Moreover, the alpha7, but not alpha3beta2* nAChR, are responsible for a fraction of the VOCC-independent nicotine-evoked Ca2+ increase that appears to be functionally coupled to ryanodine sensitive Ca2+ stores...
- Structure and regulation of voltage-gated Ca2+ channelsW A Catterall
Department of Pharmacology, Box 357280, University of Washington, Seattle, Washington 98195 7280, USA
Annu Rev Cell Dev Biol 16:521-55. 2000....
- Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutantsJ P Morello
Département de Biochimie and Le Groupe de Recherche sur le Système Nerveux Autonome, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
J Clin Invest 105:887-95. 2000....
- Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc releaseE Aizenman
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurochem 75:1878-88. 2000..Our studies suggest that under conditions of oxidative stress, Zn(2+) released from intracellular stores may contribute to the initiation of neuronal apoptosis...
- Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cellsK A Harkness
Department of Neurology, Addenbrooke s NHS Trust, Cambridge CB2 2QQ, UK
J Neuroimmunol 142:1-9. 2003..These findings suggest that endothelial cell-derived MCP-1 plays a key role in leukocyte recruitment across the blood-brain and blood-retinal barriers in vivo...
- Intracellular A-beta amyloid, a sign for worse things to come?Valentina Echeverria
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
Mol Neurobiol 26:299-316. 2002....
- Intracellular fluid flow in rapidly moving cellsKinneret Keren
Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Cell Biol 11:1219-24. 2009..We present a physical model for fluid pressure and flow in moving cells that quantitatively accounts for our experimental data...
- Transient rise in intracellular calcium produces a long-lasting increase in plasma membrane calcium pump activity in rat sensory neuronsWilliam J Pottorf
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Neurochem 83:1002-8. 2002..We conclude that PMCA-mediated Ca2+ efflux in DRG neurons is a dynamic process in which intense stimuli prime the pump for the next Ca2+ challenge...
- Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and GolgiW Xia
Department of Neurology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Biochemistry 37:16465-71. 1998..Our results indicate PS1 and APP can interact in the ER and Golgi, where PS1 is required for proper gamma-secretase processing of APP CTFs, and that PS1 mutations augment Abeta42 levels principally in Golgi-like vesicles...
- Intracellular and extracellular Abeta, a tale of two neuropathologiesA Claudio Cuello
Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
Brain Pathol 15:66-71. 2005....
- Impact of intracellular beta-amyloid in transgenic animals and cell modelsA Claudio Cuello
Department of Pharmacology and Therapeutics, McGill University, Montreal, Que, Canada
Neurodegener Dis 5:146-8. 2008..Moreover, intracellular pathology would be independent and additive to the toxic effects of the extracellular Abeta burden...
- CO2 permeability and bicarbonate transport in microperfused interlobular ducts isolated from guinea-pig pancreasH Ishiguro
Internal Medicine II, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
J Physiol 528:305-15. 2000....
- Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathwaysM Canossa
Department of Neurobiochemistry, Max Planck Institute of Neurobiology, Am Klopferspitz 18a, D 82152 Martinsried, Germany
EMBO J 20:1640-50. 2001..Thus, PLC-mediated signal transduction pathways are the common mechanisms for both Trk- and mGluRI-mediated NT secretion...
- Antigen-independent selection of intracellular stable antibody frameworksAdrian Auf der Maur
ESBATech AG, Wagistrasse 21, CH 8952 Zurich Schlieren, Switzerland
Methods 34:215-24. 2004....
- Intracellular amyloid-beta in Alzheimer's diseaseFrank M LaFerla
Department of Neurobiology and Behaviour, and Institute for Brain Aging and Dementia, University of California, Irvine, California 92697 4545, USA
Nat Rev Neurosci 8:499-509. 2007....
- Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's diseaseC Glabe
Department of Molecular Biology and Biochemistry, University of California, Irvine 92697, USA
J Mol Neurosci 17:137-45. 2001....
- Plasmodium falciparum malaria parasites display a THG-sensitive Ca2+ poolFernando P Varotti
Departamento de Fisiologia, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, Brazil
Cell Calcium 33:137-44. 2003
- Acid detection by taste receptor cellsJ A DeSimone
Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298, USA
Respir Physiol 129:231-45. 2001..We shall discuss the current status of proposed acid-sensing taste mechanisms, emphasizing pH-tracking in receptor cells...
- Time-resolved sperm responses to an egg peptide measured by stopped-flow fluorometryT Nishigaki
, , Cuernavaca, Morelos, 62250,
Biochem Biophys Res Commun 284:531-5. 2001..These time delays probably reflect biochemical processes underlying each sperm response to speract that circumscribe the time sequence of the signaling events...
- Identification of store-independent and store-operated Ca2+ conductances in Caenorhabditis elegans intestinal epithelial cellsAna Y Estevez
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Gen Physiol 122:207-23. 2003....
- Excitation and adaptation in the detection of hydrogen ions by taste receptor cells: a role for cAMP and Ca(2+)Vijay Lyall
Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
J Neurophysiol 87:399-408. 2002..However, an increase in [Ca(2+)]i stimulates pH(i) recovery, which, in turn, increases sensory adaptation to acids...
- Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic miceJin G Sheng
Department of Pathology Division of Neuropathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neurobiol Dis 14:133-45. 2003..It remains to be seen whether such events can cause neuronal dysfunction/degeneration and, with time, lead to extracellular Abeta deposits, as they occur in Alzheimer's disease...
- Cytosolic free magnesium modulates Na/Ca exchange currents in pig myocytesShao Kui Wei
Division of Cardiology A 3060, Department of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Cardiovasc Res 53:334-40. 2002..We asked whether changes in [Mg(2+)](i) in a physiologically relevant range could alter the I(NCX)...
- Enhanced intracellular stability of sFv-Fc fusion intrabodiesRandall W Strube
Department of Cancer Biology, Wake Forest University Graduate School of Arts and Sciences, Winston Salem, NC 27157, USA
Methods 34:179-83. 2004..Here, we describe the rationale and design for this strategy using two anti-cyclin E sFvs constructed for use as intrabodies...
- Distinct intracellular calcium profiles following influx through N- versus L-type calcium channels: role of Ca2+-induced Ca2+ releaseKeith Tully
Program of Neuroscience, Department of Neuobiology, University of Massachusetts Medical School, Worcester 01605, USA
J Neurophysiol 92:135-43. 2004....
- Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cellsLucia Formigli
Department of Anatomy, Histology, and Forensic Medicine, University of Florence, 50134 Florence, Italy
Am J Physiol Cell Physiol 282:C1361-73. 2002..This event, however, was unrelated to [Ca2+]i increase, because the two phenomena were temporally shifted. We propose that SPP may promote C2C12 cell contraction through Ca2+-independent mechanisms...
- Impact of progestins on estradiol potentiation of the glutamate calcium responseJon Nilsen
Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
Neuroreport 13:825-30. 2002..These results may have important implications for effective use of HRT to maintain cognitive function during menopause and aging...
- Lipopolysaccharide sensitizes microglia toward Ca(2+)-induced cell death: mode of cell death shifts from apoptosis to necrosisTakayuki Nagano
Department of Pharmacology, Hyogo College of Medicine, Hyogo, Japan
Glia 53:67-73. 2006..These results indicate that microglial activation sensitizes the cells toward cell death induced by the change in intracellular Ca2+ concentration and shifts the mode of cell death from apoptosis to necrosis...
- Store depletion-induced calcium influx in rat cerebellar astrocytesKuo Jung Lo
Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China
Br J Pharmacol 135:1383-92. 2002..7. In conclusion, in rat cerebellar astrocytes, store depletion activated a CCE via channels which were permeable to Ca(2+) and Na(+) and regulated by phosphorylation...
- Brain-derived neurotrophic factor induces long-lasting Ca2+-activated K+ currents in rat visual cortex neuronsYoshito Mizoguchi
Department of Cellular and Systems Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Eur J Neurosci 16:1417-24. 2002..While BDNF, likely acting through the Trk B receptor, was necessary for the induction of long-lasting Ca2+-activated K+ currents via intracellular Ca2+ elevation, BDNF was not necessary for the maintenance of this current...
- Nitric oxide modulates calcium entry through P/Q-type calcium channels and N-methyl-d-aspartate receptors in rat cortical neuronsGabor C Petzold
Department of Experimental Neurology, Charite University Medicine Berlin, Schumannstr 20 21, 10117 Berlin, Germany
Brain Res 1063:9-14. 2005..These results suggest that NO can modulate neuronal calcium entry during depolarization by interacting with P/Q-type VGCC and NMDAR...
- Matrix protein glycation impairs agonist-induced intracellular Ca2+ signaling in endothelial cellsNour B Bishara
Microvascular Biology Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
J Cell Physiol 193:80-92. 2002..The results demonstrate that matrix glycation impairs agonist-induced Ca(2+) (i) increases which may impact on regulatory functions of the endothelium and implicate possible involvement of oxidative stress...
- Release and sequestration of Ca2+ by a caffeine- and ryanodine-sensitive store in a sub-population of human SH-SY5Y neuroblastoma cellsFiona C Riddoch
Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle upon Tyne, UK
Cell Calcium 38:111-20. 2005..We conclude that a caffeine- and ryanodine-sensitive store can act as a Ca(2+) source and sink in SH-SY5Y cells, and that effects of the store can become obscured if data from caffeine-insensitive cells are not excluded...
- A new neuromodulatory pathway with a glial contribution mediated via A(2a) adenosine receptorsT Nishizaki
Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan
Glia 39:133-47. 2002..The results of the present study thus represent a novel neuromodulatory pathway with a glial contribution, bearing both inhibition of GLT-1 function and stimulation of glial glutamate release, as mediated via A(2a) adenosine receptors...
- Glutamate-induced increases in intracellular Ca2+ in cultured rat neocortical neuronsGang Wang
Department of Bioengineering, Faculty of Engineering, Kagoshima University, 1 21 40 Korimoto, Kagoshima 8900065, Japan
Neuroreport 13:1051-6. 2002..In both the cell body and dendritic processes, [Ca2+]i increase induced by low concentrations of glutamate was mainly due to the activation of NMDA receptors...
- AMPA glutamate receptor-mediated calcium signaling is transiently enhanced during development of oligodendrocytesTakayuki Itoh
The Children s Hospital of Philadelphia, Pennsylvania, USA
J Neurochem 81:390-402. 2002..susceptibility to excitotoxicity of cells at these stages of oligodendroglial differentiation, and is likely to be important to these cells in the trans-synaptic Ca2+-signaling from glutamatergic neurons, which occurs in hippocampus..
- Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosisB L Schwab
Molecular Toxicology, Faculty of Biology, University of Konstanz, Germany
Cell Death Differ 9:818-31. 2002..These findings suggest that caspase-mediated cleavage and inactivation of PMCAs can lead to necrosis, an event that is reduced by caspase inhibitors in brain ischemia...
- Secreted phospholipase A2 potentiates glutamate-induced calcium increase and cell death in primary neuronal culturesMark A DeCoster
Neuroscience Center, LSU Health Sciences Center, New Orleans, Louisiana 70112, USA
J Neurosci Res 67:634-45. 2002..These results indicate that sPLA2 affects neuronal responses to both nontoxic (0.1-10 microM) and toxic (=25 microM) concentrations of glutamate, implicating this enzyme in neuronal functions in pathology...
- Transient receptor potential channel activation causes a novel form of [Ca 2+]I oscillations and is not involved in capacitative Ca 2+ entry in glial cellsMaurizio Grimaldi
Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Neurosci 23:4737-45. 2003..In conclusion, in glial cells, natively expressed TRPC3s mediates a novel form of Ca 2+ signaling, distinct from capacitative Ca 2+ entry, which suggests a specific signaling function for this channel in glial cells...
- Acute effects of glucocorticoids on ATP-induced Ca2+ mobilization and nitric oxide production in cochlear spiral ganglion neuronsH Yukawa
Hearing Research Laboratory, Department of Otolaryngology, Kansai Medical University, Fumizono cho 10 15, Moriguchi, Osaka 570 8507, Japan
Neuroscience 130:485-96. 2005..The present study suggests that NO may play an important role in auditory signal transduction. Our results also indicate that glucocorticoids may rapidly affect auditory neurotransmission due to a novel non-genomic mechanism...
- Functional alterations in immature cultured rat hippocampal neurons after sustained exposure to static magnetic fieldsTakao Hirai
Laboratory of Molecular Pharmacology, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Japan
J Neurosci Res 75:230-40. 2004..These results suggest that sustained exposure to static magnetic fields may affect cellular functionality and maturity in immature cultured rat hippocampal neurons through modulation of expression of particular NMDA receptor subunits...
- Chronic interleukin-6 exposure alters metabotropic glutamate receptor-activated calcium signalling in cerebellar Purkinje neuronsThomas E Nelson
Department of Neuropharmacology, CVN 11, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Eur J Neurosci 20:2387-400. 2004..The results support the hypothesis that chronic IL-6 exposure disrupts neuronal function and thereby may contribute to the pathophysiology associated with many neurological diseases...
- Cholesterol depletion perturbs calcium handling by rat submandibular glandsM Garcia-Marcos
Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad del Pais Vasco, Bilbao, Spain
J Cell Physiol 203:429-38. 2005..At the opposite, the store-operated calcium channel (SOCC) is not affected by DRM-disruption...
- Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagationA C P Carvalho
Departament of Pharmacology, Universidade Federal de Sao Paulo, UNIFESP, Sao Paulo, Brazil
Cell Death Differ 11:1265-76. 2004..Our results show that Bax induces mitochondrial alteration that affects Ca2+ homeostasis and signaling. These changes show that Ca2+ signals might be correlated with the proapoptotic activities of Bax...
- Adenosine modulation of [Ca2+]i in cerebellar granular cells: multiple adenosine receptors involvedJavier Vacas
Area de Bioquímica C R I B, Facultad de Quimicas, Universidad de Castilla La Mancha, Camilo Jose Cela, 10, Ciudad Real, 13071, Spain
Brain Res 992:272-80. 2003..These results suggest that adenosine modulate [Ca(2+)](i) in cerebellar granule cells through different adenosine receptor subtypes which, at least in part, seem to act through R-type calcium channels...
- Differences in calcium signalling in rat peripheral sensory neuronsM Kress
Institute of Physiology and Experimental Pathophysiology, Erlangen, Germany
Neurosci Lett 354:127-30. 2004..We conclude that the compartmentalization of sensory neurons for calcium ions may be decisive on further signalling cascades accounting, for example, for neuronal plasticity...
- Hydrogen sulfide induces calcium waves in astrocytesYasuo Nagai
National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
FASEB J 18:557-9. 2004..These observations suggest that H2S induces Ca2+ waves that propagate to neighboring astrocytes...
- Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: potential application to biomolecular screeningKamondanai Hemstapat
School of Pharmacy, University of Queensland, St Lucia Campus, Brisbane, Queensland, 4072, Australia
J Pharmacol Toxicol Methods 49:81-7. 2004..Such an approach has the potential to identify lead compounds for the development of novel drugs for the treatment of epilepsy, pathological pain states, Parkinson's disease, or other neurological disorders...
- Ca(2+)-independent spine dynamics in cultured hippocampal neuronsShengxiang Zhang
Kinsmen Laboratory of Nuerology Research and Brain Research Centre, University of British Columbia, Vancouver, Columbia, Canada
Mol Cell Neurosci 25:334-44. 2004..We conclude that the basal spine motility of cultured hippocampal neurons may represent an intrinsic feature of developing neurons and is not necessarily choreographed by ongoing changes in [Ca(2+)](i) levels...
- Modulation of intercellular calcium signaling in astrocytes by extracellular calcium and magnesiumCharles Stout
Loma Linda University School of Medicine, Loma Linda, California, USA
Glia 43:265-73. 2003..These currents were inhibited by extracellular Mg(2+). We conclude that extracellular divalent cations modulate intercellular Ca(2+) signaling in astrocytes by modulating the release of ATP, possibly via connexin hemichannels...
- Inhibition of the Na+-H+ exchanger with cariporide abolishes stretch-induced calcium but not sodium accumulation in mouse ventricular myocytesDenis Kondratev
Julius Bernstein Institute of Physiology, University of Halle, Magdeburger Strasse 6, D 06097 Halle, Germany
Cell Calcium 37:69-80. 2005..The discovery that cariporide prevents the stretch-induced rise in cytosolic [Ca] demonstrates an important additional effect of the drug on calcium handling...
- Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicityAndrey Y Abramov
Mitochondrial Biology Group, Department of Physiology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 23:5088-95. 2003..Thus, astrocytes appear to be the primary target of betaA, whereas the neurotoxicity reflects the neuronal dependence on astrocytes for antioxidant support...
- Ca2+-dependent induction of intracellular Ca2+ oscillation in hippocampal astrocytes during metabotropic glutamate receptor activationYoshitoku Yoshida
Molecular Life Science Division, School of Life Science, Tokyo University of Pharmacy and Life Science, Japan
J Pharmacol Sci 97:212-8. 2005..These findings indicate the involvement of [Ca(2+)](i)-dependent regulatory mechanisms in the induction of the t-ACPD-induced oscillatory change in the [Ca(2+)](i) in astrocytes...
- Depletion of intracellular Ca2+ stores sensitizes the flow-induced Ca2+ influx in rat endothelial cellsHiu Yee Kwan
Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China
Circ Res 92:286-92. 2003....
- Role of BK potassium channels shaping action potentials and the associated [Ca(2+)](i) oscillations in GH(3) rat anterior pituitary cellsPablo Miranda
Departamento de Bioquimica y Biologia Molecular, Edificio Santiago Gascon, Campus del Cristo, Universidad de Oviedo, Oviedo, Spain
Neuroendocrinology 77:162-76. 2003....
- Intercellular calcium waves in cultured enteric glia from neonatal guinea pigWeizhen Zhang
Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
Glia 42:252-62. 2003....
- Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signalYuki Hashimotodani
Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
Neuron 45:257-68. 2005..We therefore conclude that PLCbeta1 serves as a coincidence detector through its Ca(2+) dependency for endocannabinoid release in hippocampal neurons...
- Mechanism and role of high-potassium-induced reduction of intracellular Ca2+ concentration in rat osteoclastsHiroshi Kajiya
Department of Physiological Science and Molecular Biology, Fukuoka Dental College, 2 15 1 Tamura, Sawara ku, Fukuoka 814 0193, Japan
Am J Physiol Cell Physiol 285:C457-66. 2003..Changes in membrane potential regulate osteoclastic motility by controlling the net amount of Ca2+ entry in a "reversed" voltage-dependent manner, i.e., depolarization decreases and hyperpolarization increases [Ca2+]i...
- Intracellular Cs+ activates the PKA pathway, revealing a fast, reversible, Ca2+-dependent inactivation of L-type Ca2+ currentFabien Brette
Centre National de la Recherche Scientifique Unité Mixte de Recherche 6542, Universite de Tours, France
Am J Physiol Cell Physiol 285:C310-8. 2003..Cs+ seems to activate the cAMP-dependent protein kinase pathway when used as a substitute for K+ in the pipette solution...
- A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytesJun Ishikawa
Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
J Immunol 170:4441-9. 2003..Furthermore, YM-58483 would be a candidate for the study of capacitative Ca(2+) entry mechanisms through SOC/CRAC channels and for identification of putative Ca(2+) channel genes...
- Intracellular calcium measurements as a method in studies on activity of purinergic P2X receptor channelsMu Lan He
Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
Am J Physiol Cell Physiol 285:C467-79. 2003....
- Phosphatidylinositol 3-kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferationLarissa Lipskaia
INSERM U446 IFR 75, Institut de signalisation et innovation thérapeutique, Faculte de Pharmacie, Tour D4, 5 rue JB Clement, 92296 Chatenay Malabry, France
Circ Res 92:1115-22. 2003..Blockade of the Ca2+-induced Ca2+ release mechanism and dephosphorylation of pCREB contribute but were not sufficient to induce a proliferating phenotype...
- Gap junction channels coordinate the propagation of intercellular Ca2+ signals generated by P2Y receptor activationS O Suadicani
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Glia 48:217-29. 2004..These data indicate that in 1321N1 cells gap junctional communication provides intercellular integration of Ca(2+) signals generated by P2YR activation, thus coordinating the propagation of intercellular calcium waves...
- Dendritic calcium encodes striatal neuron output during up-statesJason N D Kerr
Unit of Neural Network Physiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 22:1499-512. 2002..We suggest that this conveys information about the contribution of a spiny projection neuron to a basal ganglia output specifically back to the corticostriatal synapses involved in generating these outputs...
- Ca2+ signaling regulated by an ATP-dependent autocrine mechanism in astrocytesH Shiga
Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan
Neuroreport 12:2619-22. 2001..These two different Ca2+ cascades are involved in signal transduction and may function separately during intercellular communication...
- Tuning the mechanosensitivity of a BK channel by changing the linker lengthHuCheng Zhao
Institute of Biomechanics and Medical Engineering, Tsinghua University, Beijing 100084, PR China
Cell Res 18:871-8. 2008..Our results are consistent with the idea that membrane stretch is transferred to the gate via the linker-gating ring complex of the MS BK channels...
- Atypical neuroleptic drugs downregulate dopamine sensitivity in rat cortical and striatal astrocytesB Reuss
Neuroanatomy and Interdisciplinary Center for Neurosciences (IZN, University of Heidelberg, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany
Mol Cell Neurosci 18:197-209. 2001....
- Glutamate pretreatment affects Ca2+ signaling in processes of astrocyte pairsRagunathan Padmashri
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
J Neurochem 100:105-17. 2007....
- Glutamate-mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR-induced release of Ca++ from intracellular stores and is prevented by estradiolGenell D Hilton
Department of Physiology, University of Maryland, Baltimore, Maryland 21201, USA
Eur J Neurosci 24:3008-16. 2006....
- Beta-amyloid enhances intracellular calcium rises mediated by repeated activation of intracellular calcium stores and nicotinic receptors in acutely dissociated rat basal forebrain neuronsJames H Chin
Department of Medicine, Division of Neurology, University of Alberta, 530 Heritage Medical Research Centre, Edmonton, AB, Canada T6G 2S2
Brain Cell Biol 35:173-86. 2006....
- PLC-dependent intracellular Ca2+ release was associated with C6-ceramide-induced inhibition of Na+ current in rat granule cellsZheng Liu
Institute of Brain Science, School of Life Sciences, Fudan University, Shanghai, PR China
J Neurochem 106:2463-75. 2008....
- Activator protein-1 responsive to the group II metabotropic glutamate receptor subtype in association with intracellular calcium in cultured rat cortical neuronsChie Sugiyama
Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
Neurochem Int 51:467-75. 2007..These results suggest that activation of the group II mGluR subtype would modulate the gene expression mediated by AP1 through increased intracellular Ca(2+) levels in cultured rat cortical neurons...
- Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulationKirk E Dineley
Department of Biology, Francis Marion University, Florence, SC, USA
J Neurochem 106:2184-93. 2008..We conclude that glutamate-induced [Zn(2+)](i) transients are caused in part by [Ca(2+)](i)-induced reactive oxygen species that arises from both cytosolic and mitochondrial sources...
- Microtubule disruption by colchicine reversibly enhances calcium signaling in intact rat cardiac myocytesB G Kerfant
Physiopathologie Cardiovasculaire, INSERM U-390, Montpellier, France
Circ Res 88:E59-65. 2001..In summary, we demonstrate that microtubule disruption by colchicine reversibly modulates Ca(2+) signaling in cardiac cells with intact sarcolemma...
- Reverse mode Na+/Ca2+ exchangers trigger the release of Ca2+ from intracellular Ca2+ stores in cultured rat embryonic cortical neuronsMeng Pei Wu
Institute of Zoology, Department of Life Science, National Taiwan University, Taipei, Taiwan, ROC
Brain Res 1201:41-51. 2008....
- Comparison of intracellular calcium signals evoked by heat and capsaicin in cultured rat dorsal root ganglion neurons and in a cell line expressing the rat vanilloid receptor, VR1J R Savidge
Novartis Institute for Medical Sciences, 5 Gower Place, WC1E 6BN, London, UK
Neuroscience 102:177-84. 2001....
- Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated culturesH Tanaka
Department of Neurology, Tokyo Medical and Dental University School of Medicine, Japan
J Muscle Res Cell Motil 21:507-26. 2000....
- Altered cardiac sarcoplasmic reticulum function of intact myocytes of rat ventricle during metabolic inhibitionC L Overend
Department of Medicine, University of Manchester, Manchester, UK
Circ Res 88:181-7. 2001..In the context of ischemia, this extra accumulation of Ca(2+) would present a risk of potentially arrhythmogenic, spontaneous release of Ca(2+) on reperfusion of the tissue...
- Ca2+ flux and signaling implications by nicotinic acetylcholine receptors in rat medial habenulaXiaochuan Guo
Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham, 1825 University Boulevard, Birmingham AL 35294 2182, USA
J Neurophysiol 97:83-92. 2007....
- Bidirectional Ca2+ coupling of mitochondria with the endoplasmic reticulum and regulation of multimodal Ca2+ entries in rat brown adipocytesMasako Kuba
Laboratory of Anatomy and Physiology, School of Nutritional Sciences, Nagoya Univ of Arts and Sciences, 57 Takenoyama, Iwasaki cho, Nissin, Aichi 470 0196, Japan
Am J Physiol Cell Physiol 292:C896-908. 2007....
- No evidence for bradykinin B1 receptors in rat dorsal root ganglion neuronsM Brand
Institute of Physiology, , , , Germany
Neuroreport 12:3165-8. 2001..Normal external solution applied at this flow rate constituted a mechanical stimulus causing a response in some neurons. Thus, in comparable set-ups mechanosensitivity has first to be tested to avoid masking effects...
- Odorant receptors directly activate phospholipase C/inositol-1,4,5-trisphosphate coupled to calcium influx in Odora cellsGuang Liu
Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Neurochem 96:1591-605. 2006..Thus, individual ORs are capable of elevating calcium through pathways not directly mediated by cAMP and this may provide another avenue for odorant signaling in the olfactory system...
- Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytesLixia Zhao
Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
Brain Res 943:117-31. 2002..To our knowledge, this is the first documentation of a vasopressin receptor-induced calcium signaling cascade in cortical astrocytes and the first documentation of vasopressin receptor induction of nuclear calcium signaling...
- Effects of 17beta-estradiol on intracellular calcium changes and neuronal survival after mechanical strain injury in neuronal-glial culturesSaitida Lapanantasin
Department of Anatomy and Center for Neuroscience, Faculty of Science, Mahidol University, Bangkok, Thailand
Synapse 60:406-10. 2006..These results demonstrate the neuroprotective activity of E2 in an in vitro model of neuronal injury, and suggest that such effects may be related to the ability of E2 to modulate [Ca(2+)](i)...
- Effects of intracellular and extracellular concentrations of Ca2+, K+, and Cl- on the Na+-dependent Mg2+ efflux in rat ventricular myocytesMichiko Tashiro
Department of Physiology, Tokyo Medical University, Tokyo, Japan
Biophys J 91:244-54. 2006..2%, n=8); and 3), extracellular and intracellular perfusion with K+-free and Cl--free solutions (71.6+/-5.1%, n=5). These results suggest that Mg2+ is transported in exchange with Na+, but not with Ca2+, K+, or Cl-, in cardiac myocytes...
- Dual role of calbindin-D28K in vesicular catecholamine release from mouse chromaffin cellsR H S Westerink
Cellular and Molecular Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
J Neurochem 99:628-40. 2006..Consequently, the possibility that calbindin-D(28K) functions not only as a Ca(2+) buffer but also as a modulator of vesicular catecholamine release is discussed...
- Neuroendocrine mechanisms during reversible hypovolaemic shock in humans with emphasis on the histaminergic and serotonergic systemS H Matzen
Department of Medical Physiology, Panum Institute, Denmark
Acta Physiol Scand Suppl 628:1-31. 1995..extracellular fluid only, changing more than the high frequency current that passes extra as well as intracellular fluid. Central hypovolaemia was found to stimulate the pituitary-adrenal axis, and the development of hypotension ..
- Electrolytes and trace elements in human breast cyst fluidAli Riza Sisman
Department of Biochemistry, Faculty of Medicine, Dokuz Eylul University, Inciralti, Izmir, Turkey
Biol Trace Elem Res 128:18-30. 2009..Type I cysts contain fluid with an electrolyte composition similar to that of intracellular fluid (Na/K ratio <3), whereas type II cysts fluid's content resembles that of plasma (Na/K ratio >3)...
- Compulsory hyperventilation and hypocapnia of patients with Leigh syndrome associated with SURF1 gene mutations as a cause of low serum bicarbonatesE Pronicka
Department of Metabolic Diseases, Children s Memorial Health Institute, Warsaw, Poland
J Inherit Metab Dis 24:707-14. 2001..Acidification of intracellular fluid by accumulation of lactate may compensate the effect of respiratory alkalosis...
- Fluid volume control during short-term space flight and implications for human performanceD E Watenpaugh
Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
J Exp Biol 204:3209-15. 2001..Extracellular fluid volume decreases by 10-15% in microgravity, and intracellular fluid volume appears to increase. Total red blood cell mass decreases by approximately 10% within 1 week in space...
- Water and the cytoskeletonJ F Leterrier
UMR CNRS 6558, University of Poitiers, France
Cell Mol Biol (Noisy-le-grand) 47:901-23. 2001The diffusion of intracellular fluid and solutes is mainly limited by the density and the geometry of crossbridges between cytoskeletal polymers mediating the formation of an integrated cytoplasmic scaffold...
- [Hyperkalemias]J Rado
Nephrologia Hypertonia Osztály, Uzsoki utcai Kórház, Budapest
Orv Hetil 140:2611-8. 1999..K] intake and output) as well as the "internal balance" (distribution of K in the extracellular and intracellular fluid compartments). Factors playing a role in it are: the upright posture, physical activity and hyperosmolality...
- Epithelial magnesium transport and regulation by the kidneyG A Quamme
Department of Medicine, University of British Columbia, Vancouver, BC Canada
Front Biosci 5:D694-711. 2000Magnesium is the fourth most abundant cation in the body and the second most common cation in the intracellular fluid. It is the kidney that provides the most sensitive control for magnesium balance...
- Pathomechanisms of cystoid macular edemaAndreas Bringmann
Department of Ophthalmology, Eye Clinic, University of Leipzig, Germany
Ophthalmic Res 36:241-9. 2004..CME) is a well-known endpoint of various ocular diseases, but the relative pathogenic impact of extra- and intracellular fluid accumulation within the retinal tissue still remains uncertain...
- Effect of water phase salt content and storage temperature on Listeria monocytogenes survival in chum salmon (Oncorhynchus keta) roe and caviar (ikura)Joong Han Shin
Dept of Food Science and Human Nutrition, Washington State Univ, Pullman, WA 99164 6376, USA
J Food Sci 72:M160-5. 2007..Components in the salmon egg intracellular fluid appear to inhibit the growth of L. monocytogenes...
- Acute effects of sodium ingestion on thirst and cardiovascular functionNina S Stachenfeld
The John B Pierce Laboratory and Yale University School of Medicine, New Haven, Connecticut 06519, USA
Curr Sports Med Rep 7:S7-13. 2008..water is used to replenish body water, plasma volume is preferentially restored over the interstitial and intracellular fluid space, suppressing plasma sodium concentration and removing the dipsogenic drive long before total body ..
- Bioimpedance spectroscopy technique: intra-, extracellular, and total body waterL E Armstrong
University of Connecticut, Department of Physiology and Neurobiology, Storrs 06269 1110, USA
Med Sci Sports Exerc 29:1657-63. 1997..frequency bioimpedance spectroscopy (BIS) technique that estimates extracellular fluid volume (ECV), intracellular fluid volume (ICV), and total body water (TBW)...
- Measuring Intra/Extracellular Volume and HemodynamicsLeslie Montgomery; Fiscal Year: 2003..Swept frequency bioimpedance by EIS has been used to estimate intravascular, interstitial and intracellular fluid volumes...
- THE CARDIAC RESPONSE TO CHRONIC METABOLIC ACIDOSISJOHN BETTICE; Fiscal Year: 1980..has been linked to a fall in the intracellular pH and to changes in the electrolyte composition of the intracellular fluid of the heart...
- MANAGEMENT OF COMPARTMENT SYNDROME WITH ULTRAFILTRATIONWILLIAM FOWLER; Fiscal Year: 2002..an innovative use of tissue ultrafiltration (UF) to reduce tissue pressure by removing interstitial and/or intracellular fluid volume, and to use the increased fluid levels of metabolites to improve diagnosis...
- Exploring Growth Energy Expenditure in Normal-Weight and Overweight ChildrenZiMian Wang; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- MICELLAR CARRIERS FOR SPARINGLY SOLUBLE PHARMACEUTICALSVladimir Torchilin; Fiscal Year: 2007..unreadable] [unreadable]..
- TRAINING IN MOLECULAR NEUROBIOLOGYWilliam Catterall; Fiscal Year: 2008..The training program will integrate the substantial expertise of this group of faculty in a coordinated pre-doctoral and post-doctoral training effort. ..
- Genetic analysis of C. elegans cellular ormoregulationKevin Strange; Fiscal Year: 2004..elegans will likely provide unique insights into osmoregulation, signaling mechanisms, and cellular stress and damage repair )rocesses in kidney cells as well as other mammalian cell types and tissues. ..
- MICELLAR CARRIERS FOR SPARINGLY SOLUBLE PHARMACEUTICALSVladimir Torchilin; Fiscal Year: 2002..abstract_text> ..
- Culture of differentiated C elegans embryonic cellsKevin Strange; Fiscal Year: 2002..The speed and economy with which this can be done in C. elegans cannot be duplicated in other metazoan animals. ..
- Fifth International Nanomedicine and Drug DeliveryVladimir Torchilin; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Synaptic Alterations in the Cerebral Cortex during AgingA Cuello; Fiscal Year: 2005..abstract_text> ..
- Effects of intracellular angiotensin IIJulia Cook; Fiscal Year: 2009..abstract_text> ..
- Long-Circulating Polymer-Modified LiposomesVladimir Torchilin; Fiscal Year: 2008..abstract_text> ..
- CYROBIOLOGICAL PRESERVATION OF ANOPHELES EMBRYOSPeter Mazur; Fiscal Year: 2001..Such a mutant has been isolated in a related species, Anopheles quadrimaculatus. We also propose to collaborate with the Laboratory of Parasitic Diseases at NIH in the cryopreservation of A gambiae larvae. ..
- MULTIFUNCTIONAL STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERSVladimir P Torchilin; Fiscal Year: 2010....
- ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGINGVladimir Torchilin; Fiscal Year: 2006..abstract_text> ..
- Mechanisms and use of antidiabetic agents in brain aging and Alzheimer's diseaseOlivier Thibault; Fiscal Year: 2008..Furthermore, these studies will contribute to future drug discovery efforts to generate new TZD-derived or similar drugs for the treatment of AD. [unreadable] [unreadable] [unreadable]..
- Antioxidant vitamins in models of Alzheimer's DiseaseJames May; Fiscal Year: 2008..If antioxidant vitamins ameliorate toxicity in cell and animal models of Alzheimer's disease, then oxidant stress is involved in disease progression, and antioxidant vitamin supplements may be beneficial. ..
- Structure/Function of Peroxisomes in NeuroinflammationInderjit Singh; Fiscal Year: 2008..unreadable] [unreadable]..
- Kinase-phosphatase complex in transducing pain signalsXian Min Yu; Fiscal Year: 2008..No such studies have yet been conducted in Vc, and so the proposed research promises to reveal novel molecular networks involved in the regulation of orofacial pain. [unreadable] [unreadable]..
- Liberation of Intracellular Zinc and Neuronal Cell DeathElias Aizenman; Fiscal Year: 2007..With this information, we hope to uncover novel therapeutic strategies to prevent or halt the progression of these and other neurodegenerative conditions. ..
- Structural Studies of the Innate Immune PathwayMICHAEL LASKER; Fiscal Year: 2008....
- 2008 Calcium Signaling and Disease SGP ConferenceIlya Bezprozvanny; Fiscal Year: 2008..The major purpose of the SGP is to host a symposium each year on a different subject of wide interest to cell biologists, physiologists and biophysicists. [unreadable] [unreadable] [unreadable]..
- Estrogen & Progesterone Effects on Orthostatic ToleranceNINA STACHENFELD; Fiscal Year: 2010..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
- Chemokines in pathogenesis of Experimental ArthritisSEEMA SINGH AHUJA; Fiscal Year: 2010..Thus information obtained from proposed studies which explore how CCR2 modulates arthritis will have significant impact on potential therapeutic strategies to treat this chronic deblitating disease. ..
- Gating of Neuronal Kv4 ChannelsMANUEL L COVARRUBIAS; Fiscal Year: 2010..This work is likely to impact the stud of neurological entities possibly linked to the Kv4 channel complex, such as epilepsy, pain plasticity, neur egenerative disorders, and autism. ..
- IL-6 Regulation of Hippocampal Synaptic FunctionDonna L Gruol; Fiscal Year: 2010..The proposed studies focus on this issue as it relates to CNS disorders. ..
- Lipid Raft Microdomains in Neutrophil FunctionROBERT GARY SITRIN; Fiscal Year: 2010..Hopefully, targeting the function of lipid raft microdomains will engender new therapeutic strategies for enhancing antimicrobial defenses and suppressing the deleterious effects of acute inflammation. ..
- Mechanism of Nicotine Action in the Healing SkeletonMichael Zuscik; Fiscal Year: 2009....
- Mechanisms of activation of vagal afferent neuronsSteven Simasko; Fiscal Year: 2009..A better appreciation of this important signaling pathway will contribute to the understanding of energy homeostasis and GI function, and aid in the design of therapeutic interventions for better health. ..
- Regulation of Cx43 by Src and Novel Interacting ProteinsAlan Lau; Fiscal Year: 2009....
- A Novel Inhibitor of Stat3 for Prostate Cancer TherapyNaijie Jing; Fiscal Year: 2009..abstract_text> ..
- SHEAR STRESS EFFECTS ON ENDOTHELIAL TRANSPORTJohn M Tarbell; Fiscal Year: 2010..abstract_text> ..
- Lipid Transport-Connecting Fundamental Membrane Assembly To Human DiseaseDENNIS VOELKER; Fiscal Year: 2008..7. Project Narrative N/A [unreadable] [unreadable] [unreadable]..
- NONINVASIVE MEASUREMENT OF ENERGY EXPENDITURE IN HUMANSDale Schoeller; Fiscal Year: 2007..These studies will provide important guidelines for the prescription of exercise for the prevention and treatment of obesity. ..
- The Role of p53 and 14-3-3 in Genomic InstabilityJesse Martinez; Fiscal Year: 2008....
- DEVELOPMENTAL CIRCUITS IN GASTRULATION AND NEURULATIONMarc Kirschner; Fiscal Year: 2008..Our major approach here is to examine the early embryology of the acorn worm, Saccoglossus kowalevskii, and identify genes which in vertebrates play a major role in the Organizer. ..
- Antioxidant Functions of Lipoic AcidJames May; Fiscal Year: 2004..Despite the widespread use of lipoic acid, these studies are necessary to establish the biological basis and rationale for the clinical use of the agent. ..
- Meeting of American Society for Reproductive Immunology:Gil Mor; Fiscal Year: 2003..abstract_text> ..
- MOLECULAR ANALYSIS OF GLP-1 RECEPTOR ACTIVATIONMartin Beinborn; Fiscal Year: 2003..Receptor will be expressed in cell lines derived from beta cells and its ability to modulate cAMP levels in the absence of ligands evaluated. ..
- SEX HORMONES AND BODY FLUID REGULATIONNINA STACHENFELD; Fiscal Year: 2003....
- DYNAMICS OF CALMODULIN IN NEURONSSALLY KIM; Fiscal Year: 2003..These studies will provide essential information for understanding how neurons process information through the Ca2+/calmodulin-dependent signaling pathway. ..
- WALL SHEAR STRESS IN THE CARDIOVASCULAR SYSTEMJOHN TARBELL; Fiscal Year: 2003....
- BEHAVIORAL AND VIROLOGIC FEATURES OF HIV+ IDUS IN CHINAXiao Fang Yu; Fiscal Year: 2002..These aims will be carried out in Guangxi Province through a longitudinal investigation of 600 drug users about whom demographic, social, and drug use information will be collected and analyzed. ..
- DEVELOPING A POTENT INHIBITOR OF HIV-I INTEGRASENaijie Jing; Fiscal Year: 2001....
- MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASEGeorge Kaysen; Fiscal Year: 2001..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..
- EVALUATION OF HIV GAG DNA VACCINE TO MAX T HELPER/CTLXiao Fang Yu; Fiscal Year: 2001..C) Combination studies by using DNA vectors identified from this specific aim with DNA vectors identified from specific aim 1. ..
- ALCOHOL, HIV, AND THE BRAINAdolf Pfefferbaum; Fiscal Year: 2004..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
- NEURONAL ACTIONS OF HOST FACTORS IN NEUROAIDSDONNA GRUOL; Fiscal Year: 2005..The overall design will address effects of both acute and chronic chemokine exposure on neuronal cell function and will include examination of two distinct classes of neurons, excitatory glutamatergic and inhibitory GABAergic neurons. ..
- Multiplex arrays using Confocal Raman for BRCA1 alternative splice profilingJoseph Irudayaraj; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Modulating IBM pathology in transgenic miceFrank LaFerla; Fiscal Year: 2005....
- Role of prion protein in neuronal survivalAndrea LeBlanc; Fiscal Year: 2006..The result of these experiments will clearly define the neuroprotective role of PrP against Bax mediated cell death. ..
- Mechanisms of Alcohol Effects on SleepSteven Simasko; Fiscal Year: 2006..Such interventions could prove to be a useful adjunct to treat recovering alcoholics since prolonged sleep disturbances are a predicting factor for relapse into drinking behavior. ..
- Investigation of Human Muscle Function in vivoBRUCE DAMON; Fiscal Year: 2005..In this application we have requested partial support for the trainees to attend and benefit from the workshop; we have also requested support for a minority trainee travel stipend program...
- Quantifying Oxidative Metabolism in Diabetic MuscleBRUCE DAMON; Fiscal Year: 2005..Moreover, these techniques will be suitable for future studies of the effects of exercise training or other interventions in diabetic animal models. ..
- Effect of Pertussis Toxin on Cough in Guinea PigNICHOLAS CARBONETTI; Fiscal Year: 2005..abstract_text> ..
- Magnex Model MRBR 7T/201 AS Shielded Magnet SystemJean Philippe Galons; Fiscal Year: 2005..7 Tesla platform. Therefore, the need to acquire new imaging capabilities and the growth of the UoA MRI imaging community are the main justification for the present request. ..
- LASER DOPPLER VELOCIMETER SYSTEM FOR BIOMEDICAL STUDIESJOHN TARBELL; Fiscal Year: 2001..The system will be the primary measurement system for the ongoing research in cardiovascular prosthetics including mechanical heart valve cavitation and ventricular assist devices. ..
- Mechanisms Underlying the Cognitive Function of SleepSubimal Datta; Fiscal Year: 2009....
- Regulation of calcium signaling pathways by presenilinsFrank LaFerla; Fiscal Year: 2005..Lastly, by manipulating calcium signaling and determining its effects on AB production, aim 5 will address whether the effects of presenilin mutations on calcium signaling are necessary and/or sufficient to increase Ab formation. ..
- Regulation of CART Expression in Rat Nucleus AccumbensDouglas Jones; Fiscal Year: 2007..abstract_text> ..
- Studies of Diacylglycerol-Binding ProteinsWonhwa Cho; Fiscal Year: 2009....
- INNER RETINAL CONTRIBUTIONS TO THE ERGBret Hughes; Fiscal Year: 2003....