intracellular fluid

Summary

Summary: The fluid inside CELLS.

Top Publications

  1. pmc Separation and characterization of currents through store-operated CRAC channels and Mg2+-inhibited cation (MIC) channels
    Murali Prakriya
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Gen Physiol 119:487-507. 2002
  2. ncbi The extracellular fluid-to-intracellular fluid volume ratio is associated with large-artery structure and function in hemodialysis patients
    Yao Ping Lin
    Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Am J Kidney Dis 42:990-9. 2003
  3. ncbi Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons
    John M Power
    Division of Neuroscience, John Curtin School for Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Neurosci 22:3454-62. 2002
  4. ncbi Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways
    Philipp Henneke
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 169:3970-7. 2002
  5. ncbi Intracellular Ca2+ signals evoked by stimulation of nicotinic acetylcholine receptors in SH-SY5Y cells: contribution of voltage-operated Ca2+ channels and Ca2+ stores
    Federico A Dajas-Bailador
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    J Neurochem 81:606-14. 2002
  6. ncbi Structure and regulation of voltage-gated Ca2+ channels
    W A Catterall
    Department of Pharmacology, Box 357280, University of Washington, Seattle, Washington 98195 7280, USA
    Annu Rev Cell Dev Biol 16:521-55. 2000
  7. pmc Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants
    J P Morello
    Département de Biochimie and Le Groupe de Recherche sur le Système Nerveux Autonome, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Clin Invest 105:887-95. 2000
  8. ncbi Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release
    E Aizenman
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurochem 75:1878-88. 2000
  9. ncbi Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cells
    K A Harkness
    Department of Neurology, Addenbrooke s NHS Trust, Cambridge CB2 2QQ, UK
    J Neuroimmunol 142:1-9. 2003
  10. ncbi Intracellular A-beta amyloid, a sign for worse things to come?
    Valentina Echeverria
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Mol Neurobiol 26:299-316. 2002

Research Grants

Detail Information

Publications227 found, 100 shown here

  1. pmc Separation and characterization of currents through store-operated CRAC channels and Mg2+-inhibited cation (MIC) channels
    Murali Prakriya
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Gen Physiol 119:487-507. 2002
    ....
  2. ncbi The extracellular fluid-to-intracellular fluid volume ratio is associated with large-artery structure and function in hemodialysis patients
    Yao Ping Lin
    Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Am J Kidney Dis 42:990-9. 2003
    ..It is not clear how body fluid distribution affects large-artery structure and function in patients with ESRD...
  3. ncbi Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons
    John M Power
    Division of Neuroscience, John Curtin School for Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Neurosci 22:3454-62. 2002
    ..Because rises in nuclear calcium are known to initiate the transcription of novel genes, we suggest that these actions of cholinergic stimulation may underlie its effects on learning and memory...
  4. ncbi Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways
    Philipp Henneke
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 169:3970-7. 2002
    ..We conclude that the inflammatory, bactericidal, and phagocytic responses to GBS occur via parallel but independent processes...
  5. ncbi Intracellular Ca2+ signals evoked by stimulation of nicotinic acetylcholine receptors in SH-SY5Y cells: contribution of voltage-operated Ca2+ channels and Ca2+ stores
    Federico A Dajas-Bailador
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    J Neurochem 81:606-14. 2002
    ..Moreover, the alpha7, but not alpha3beta2* nAChR, are responsible for a fraction of the VOCC-independent nicotine-evoked Ca2+ increase that appears to be functionally coupled to ryanodine sensitive Ca2+ stores...
  6. ncbi Structure and regulation of voltage-gated Ca2+ channels
    W A Catterall
    Department of Pharmacology, Box 357280, University of Washington, Seattle, Washington 98195 7280, USA
    Annu Rev Cell Dev Biol 16:521-55. 2000
    ....
  7. pmc Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants
    J P Morello
    Département de Biochimie and Le Groupe de Recherche sur le Système Nerveux Autonome, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Clin Invest 105:887-95. 2000
    ....
  8. ncbi Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release
    E Aizenman
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurochem 75:1878-88. 2000
    ..Our studies suggest that under conditions of oxidative stress, Zn(2+) released from intracellular stores may contribute to the initiation of neuronal apoptosis...
  9. ncbi Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cells
    K A Harkness
    Department of Neurology, Addenbrooke s NHS Trust, Cambridge CB2 2QQ, UK
    J Neuroimmunol 142:1-9. 2003
    ..These findings suggest that endothelial cell-derived MCP-1 plays a key role in leukocyte recruitment across the blood-brain and blood-retinal barriers in vivo...
  10. ncbi Intracellular A-beta amyloid, a sign for worse things to come?
    Valentina Echeverria
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Mol Neurobiol 26:299-316. 2002
    ....
  11. pmc Intracellular fluid flow in rapidly moving cells
    Kinneret Keren
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Cell Biol 11:1219-24. 2009
    ..We present a physical model for fluid pressure and flow in moving cells that quantitatively accounts for our experimental data...
  12. ncbi Transient rise in intracellular calcium produces a long-lasting increase in plasma membrane calcium pump activity in rat sensory neurons
    William J Pottorf
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Neurochem 83:1002-8. 2002
    ..We conclude that PMCA-mediated Ca2+ efflux in DRG neurons is a dynamic process in which intense stimuli prime the pump for the next Ca2+ challenge...
  13. ncbi Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi
    W Xia
    Department of Neurology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Biochemistry 37:16465-71. 1998
    ..Our results indicate PS1 and APP can interact in the ER and Golgi, where PS1 is required for proper gamma-secretase processing of APP CTFs, and that PS1 mutations augment Abeta42 levels principally in Golgi-like vesicles...
  14. ncbi Intracellular and extracellular Abeta, a tale of two neuropathologies
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Brain Pathol 15:66-71. 2005
    ....
  15. ncbi Impact of intracellular beta-amyloid in transgenic animals and cell models
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Que, Canada
    Neurodegener Dis 5:146-8. 2008
    ..Moreover, intracellular pathology would be independent and additive to the toxic effects of the extracellular Abeta burden...
  16. pmc CO2 permeability and bicarbonate transport in microperfused interlobular ducts isolated from guinea-pig pancreas
    H Ishiguro
    Internal Medicine II, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Physiol 528:305-15. 2000
    ....
  17. pmc Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways
    M Canossa
    Department of Neurobiochemistry, Max Planck Institute of Neurobiology, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 20:1640-50. 2001
    ..Thus, PLC-mediated signal transduction pathways are the common mechanisms for both Trk- and mGluRI-mediated NT secretion...
  18. ncbi Antigen-independent selection of intracellular stable antibody frameworks
    Adrian Auf der Maur
    ESBATech AG, Wagistrasse 21, CH 8952 Zurich Schlieren, Switzerland
    Methods 34:215-24. 2004
    ....
  19. ncbi Intracellular amyloid-beta in Alzheimer's disease
    Frank M LaFerla
    Department of Neurobiology and Behaviour, and Institute for Brain Aging and Dementia, University of California, Irvine, California 92697 4545, USA
    Nat Rev Neurosci 8:499-509. 2007
    ....
  20. ncbi Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease
    C Glabe
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92697, USA
    J Mol Neurosci 17:137-45. 2001
    ....
  21. ncbi Plasmodium falciparum malaria parasites display a THG-sensitive Ca2+ pool
    Fernando P Varotti
    Departamento de Fisiologia, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cell Calcium 33:137-44. 2003
  22. ncbi Acid detection by taste receptor cells
    J A DeSimone
    Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Respir Physiol 129:231-45. 2001
    ..We shall discuss the current status of proposed acid-sensing taste mechanisms, emphasizing pH-tracking in receptor cells...
  23. ncbi Time-resolved sperm responses to an egg peptide measured by stopped-flow fluorometry
    T Nishigaki
    , , Cuernavaca, Morelos, 62250,
    Biochem Biophys Res Commun 284:531-5. 2001
    ..These time delays probably reflect biochemical processes underlying each sperm response to speract that circumscribe the time sequence of the signaling events...
  24. pmc Identification of store-independent and store-operated Ca2+ conductances in Caenorhabditis elegans intestinal epithelial cells
    Ana Y Estevez
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Gen Physiol 122:207-23. 2003
    ....
  25. ncbi Excitation and adaptation in the detection of hydrogen ions by taste receptor cells: a role for cAMP and Ca(2+)
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
    J Neurophysiol 87:399-408. 2002
    ..However, an increase in [Ca(2+)]i stimulates pH(i) recovery, which, in turn, increases sensory adaptation to acids...
  26. ncbi Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice
    Jin G Sheng
    Department of Pathology Division of Neuropathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neurobiol Dis 14:133-45. 2003
    ..It remains to be seen whether such events can cause neuronal dysfunction/degeneration and, with time, lead to extracellular Abeta deposits, as they occur in Alzheimer's disease...
  27. ncbi Cytosolic free magnesium modulates Na/Ca exchange currents in pig myocytes
    Shao Kui Wei
    Division of Cardiology A 3060, Department of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Cardiovasc Res 53:334-40. 2002
    ..We asked whether changes in [Mg(2+)](i) in a physiologically relevant range could alter the I(NCX)...
  28. ncbi Enhanced intracellular stability of sFv-Fc fusion intrabodies
    Randall W Strube
    Department of Cancer Biology, Wake Forest University Graduate School of Arts and Sciences, Winston Salem, NC 27157, USA
    Methods 34:179-83. 2004
    ..Here, we describe the rationale and design for this strategy using two anti-cyclin E sFvs constructed for use as intrabodies...
  29. ncbi Distinct intracellular calcium profiles following influx through N- versus L-type calcium channels: role of Ca2+-induced Ca2+ release
    Keith Tully
    Program of Neuroscience, Department of Neuobiology, University of Massachusetts Medical School, Worcester 01605, USA
    J Neurophysiol 92:135-43. 2004
    ....
  30. ncbi Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells
    Lucia Formigli
    Department of Anatomy, Histology, and Forensic Medicine, University of Florence, 50134 Florence, Italy
    Am J Physiol Cell Physiol 282:C1361-73. 2002
    ..This event, however, was unrelated to [Ca2+]i increase, because the two phenomena were temporally shifted. We propose that SPP may promote C2C12 cell contraction through Ca2+-independent mechanisms...
  31. ncbi Impact of progestins on estradiol potentiation of the glutamate calcium response
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Neuroreport 13:825-30. 2002
    ..These results may have important implications for effective use of HRT to maintain cognitive function during menopause and aging...
  32. ncbi Lipopolysaccharide sensitizes microglia toward Ca(2+)-induced cell death: mode of cell death shifts from apoptosis to necrosis
    Takayuki Nagano
    Department of Pharmacology, Hyogo College of Medicine, Hyogo, Japan
    Glia 53:67-73. 2006
    ..These results indicate that microglial activation sensitizes the cells toward cell death induced by the change in intracellular Ca2+ concentration and shifts the mode of cell death from apoptosis to necrosis...
  33. pmc Store depletion-induced calcium influx in rat cerebellar astrocytes
    Kuo Jung Lo
    Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Br J Pharmacol 135:1383-92. 2002
    ..7. In conclusion, in rat cerebellar astrocytes, store depletion activated a CCE via channels which were permeable to Ca(2+) and Na(+) and regulated by phosphorylation...
  34. ncbi Brain-derived neurotrophic factor induces long-lasting Ca2+-activated K+ currents in rat visual cortex neurons
    Yoshito Mizoguchi
    Department of Cellular and Systems Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Eur J Neurosci 16:1417-24. 2002
    ..While BDNF, likely acting through the Trk B receptor, was necessary for the induction of long-lasting Ca2+-activated K+ currents via intracellular Ca2+ elevation, BDNF was not necessary for the maintenance of this current...
  35. ncbi Nitric oxide modulates calcium entry through P/Q-type calcium channels and N-methyl-d-aspartate receptors in rat cortical neurons
    Gabor C Petzold
    Department of Experimental Neurology, Charite University Medicine Berlin, Schumannstr 20 21, 10117 Berlin, Germany
    Brain Res 1063:9-14. 2005
    ..These results suggest that NO can modulate neuronal calcium entry during depolarization by interacting with P/Q-type VGCC and NMDAR...
  36. ncbi Matrix protein glycation impairs agonist-induced intracellular Ca2+ signaling in endothelial cells
    Nour B Bishara
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    J Cell Physiol 193:80-92. 2002
    ..The results demonstrate that matrix glycation impairs agonist-induced Ca(2+) (i) increases which may impact on regulatory functions of the endothelium and implicate possible involvement of oxidative stress...
  37. ncbi Release and sequestration of Ca2+ by a caffeine- and ryanodine-sensitive store in a sub-population of human SH-SY5Y neuroblastoma cells
    Fiona C Riddoch
    Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle upon Tyne, UK
    Cell Calcium 38:111-20. 2005
    ..We conclude that a caffeine- and ryanodine-sensitive store can act as a Ca(2+) source and sink in SH-SY5Y cells, and that effects of the store can become obscured if data from caffeine-insensitive cells are not excluded...
  38. ncbi A new neuromodulatory pathway with a glial contribution mediated via A(2a) adenosine receptors
    T Nishizaki
    Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan
    Glia 39:133-47. 2002
    ..The results of the present study thus represent a novel neuromodulatory pathway with a glial contribution, bearing both inhibition of GLT-1 function and stimulation of glial glutamate release, as mediated via A(2a) adenosine receptors...
  39. ncbi Glutamate-induced increases in intracellular Ca2+ in cultured rat neocortical neurons
    Gang Wang
    Department of Bioengineering, Faculty of Engineering, Kagoshima University, 1 21 40 Korimoto, Kagoshima 8900065, Japan
    Neuroreport 13:1051-6. 2002
    ..In both the cell body and dendritic processes, [Ca2+]i increase induced by low concentrations of glutamate was mainly due to the activation of NMDA receptors...
  40. ncbi AMPA glutamate receptor-mediated calcium signaling is transiently enhanced during development of oligodendrocytes
    Takayuki Itoh
    The Children s Hospital of Philadelphia, Pennsylvania, USA
    J Neurochem 81:390-402. 2002
    ..susceptibility to excitotoxicity of cells at these stages of oligodendroglial differentiation, and is likely to be important to these cells in the trans-synaptic Ca2+-signaling from glutamatergic neurons, which occurs in hippocampus..
  41. ncbi Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis
    B L Schwab
    Molecular Toxicology, Faculty of Biology, University of Konstanz, Germany
    Cell Death Differ 9:818-31. 2002
    ..These findings suggest that caspase-mediated cleavage and inactivation of PMCAs can lead to necrosis, an event that is reduced by caspase inhibitors in brain ischemia...
  42. ncbi Secreted phospholipase A2 potentiates glutamate-induced calcium increase and cell death in primary neuronal cultures
    Mark A DeCoster
    Neuroscience Center, LSU Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci Res 67:634-45. 2002
    ..These results indicate that sPLA2 affects neuronal responses to both nontoxic (0.1-10 microM) and toxic (=25 microM) concentrations of glutamate, implicating this enzyme in neuronal functions in pathology...
  43. ncbi Transient receptor potential channel activation causes a novel form of [Ca 2+]I oscillations and is not involved in capacitative Ca 2+ entry in glial cells
    Maurizio Grimaldi
    Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Neurosci 23:4737-45. 2003
    ..In conclusion, in glial cells, natively expressed TRPC3s mediates a novel form of Ca 2+ signaling, distinct from capacitative Ca 2+ entry, which suggests a specific signaling function for this channel in glial cells...
  44. ncbi Acute effects of glucocorticoids on ATP-induced Ca2+ mobilization and nitric oxide production in cochlear spiral ganglion neurons
    H Yukawa
    Hearing Research Laboratory, Department of Otolaryngology, Kansai Medical University, Fumizono cho 10 15, Moriguchi, Osaka 570 8507, Japan
    Neuroscience 130:485-96. 2005
    ..The present study suggests that NO may play an important role in auditory signal transduction. Our results also indicate that glucocorticoids may rapidly affect auditory neurotransmission due to a novel non-genomic mechanism...
  45. ncbi Functional alterations in immature cultured rat hippocampal neurons after sustained exposure to static magnetic fields
    Takao Hirai
    Laboratory of Molecular Pharmacology, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Japan
    J Neurosci Res 75:230-40. 2004
    ..These results suggest that sustained exposure to static magnetic fields may affect cellular functionality and maturity in immature cultured rat hippocampal neurons through modulation of expression of particular NMDA receptor subunits...
  46. ncbi Chronic interleukin-6 exposure alters metabotropic glutamate receptor-activated calcium signalling in cerebellar Purkinje neurons
    Thomas E Nelson
    Department of Neuropharmacology, CVN 11, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Neurosci 20:2387-400. 2004
    ..The results support the hypothesis that chronic IL-6 exposure disrupts neuronal function and thereby may contribute to the pathophysiology associated with many neurological diseases...
  47. ncbi Cholesterol depletion perturbs calcium handling by rat submandibular glands
    M Garcia-Marcos
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad del Pais Vasco, Bilbao, Spain
    J Cell Physiol 203:429-38. 2005
    ..At the opposite, the store-operated calcium channel (SOCC) is not affected by DRM-disruption...
  48. ncbi Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagation
    A C P Carvalho
    Departament of Pharmacology, Universidade Federal de Sao Paulo, UNIFESP, Sao Paulo, Brazil
    Cell Death Differ 11:1265-76. 2004
    ..Our results show that Bax induces mitochondrial alteration that affects Ca2+ homeostasis and signaling. These changes show that Ca2+ signals might be correlated with the proapoptotic activities of Bax...
  49. ncbi Adenosine modulation of [Ca2+]i in cerebellar granular cells: multiple adenosine receptors involved
    Javier Vacas
    Area de Bioquímica C R I B, Facultad de Quimicas, Universidad de Castilla La Mancha, Camilo Jose Cela, 10, Ciudad Real, 13071, Spain
    Brain Res 992:272-80. 2003
    ..These results suggest that adenosine modulate [Ca(2+)](i) in cerebellar granule cells through different adenosine receptor subtypes which, at least in part, seem to act through R-type calcium channels...
  50. ncbi Differences in calcium signalling in rat peripheral sensory neurons
    M Kress
    Institute of Physiology and Experimental Pathophysiology, Erlangen, Germany
    Neurosci Lett 354:127-30. 2004
    ..We conclude that the compartmentalization of sensory neurons for calcium ions may be decisive on further signalling cascades accounting, for example, for neuronal plasticity...
  51. ncbi Hydrogen sulfide induces calcium waves in astrocytes
    Yasuo Nagai
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    FASEB J 18:557-9. 2004
    ..These observations suggest that H2S induces Ca2+ waves that propagate to neighboring astrocytes...
  52. ncbi Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: potential application to biomolecular screening
    Kamondanai Hemstapat
    School of Pharmacy, University of Queensland, St Lucia Campus, Brisbane, Queensland, 4072, Australia
    J Pharmacol Toxicol Methods 49:81-7. 2004
    ..Such an approach has the potential to identify lead compounds for the development of novel drugs for the treatment of epilepsy, pathological pain states, Parkinson's disease, or other neurological disorders...
  53. ncbi Ca(2+)-independent spine dynamics in cultured hippocampal neurons
    Shengxiang Zhang
    Kinsmen Laboratory of Nuerology Research and Brain Research Centre, University of British Columbia, Vancouver, Columbia, Canada
    Mol Cell Neurosci 25:334-44. 2004
    ..We conclude that the basal spine motility of cultured hippocampal neurons may represent an intrinsic feature of developing neurons and is not necessarily choreographed by ongoing changes in [Ca(2+)](i) levels...
  54. ncbi Modulation of intercellular calcium signaling in astrocytes by extracellular calcium and magnesium
    Charles Stout
    Loma Linda University School of Medicine, Loma Linda, California, USA
    Glia 43:265-73. 2003
    ..These currents were inhibited by extracellular Mg(2+). We conclude that extracellular divalent cations modulate intercellular Ca(2+) signaling in astrocytes by modulating the release of ATP, possibly via connexin hemichannels...
  55. ncbi Inhibition of the Na+-H+ exchanger with cariporide abolishes stretch-induced calcium but not sodium accumulation in mouse ventricular myocytes
    Denis Kondratev
    Julius Bernstein Institute of Physiology, University of Halle, Magdeburger Strasse 6, D 06097 Halle, Germany
    Cell Calcium 37:69-80. 2005
    ..The discovery that cariporide prevents the stretch-induced rise in cytosolic [Ca] demonstrates an important additional effect of the drug on calcium handling...
  56. ncbi Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity
    Andrey Y Abramov
    Mitochondrial Biology Group, Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 23:5088-95. 2003
    ..Thus, astrocytes appear to be the primary target of betaA, whereas the neurotoxicity reflects the neuronal dependence on astrocytes for antioxidant support...
  57. ncbi Ca2+-dependent induction of intracellular Ca2+ oscillation in hippocampal astrocytes during metabotropic glutamate receptor activation
    Yoshitoku Yoshida
    Molecular Life Science Division, School of Life Science, Tokyo University of Pharmacy and Life Science, Japan
    J Pharmacol Sci 97:212-8. 2005
    ..These findings indicate the involvement of [Ca(2+)](i)-dependent regulatory mechanisms in the induction of the t-ACPD-induced oscillatory change in the [Ca(2+)](i) in astrocytes...
  58. ncbi Depletion of intracellular Ca2+ stores sensitizes the flow-induced Ca2+ influx in rat endothelial cells
    Hiu Yee Kwan
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China
    Circ Res 92:286-92. 2003
    ....
  59. ncbi Role of BK potassium channels shaping action potentials and the associated [Ca(2+)](i) oscillations in GH(3) rat anterior pituitary cells
    Pablo Miranda
    Departamento de Bioquimica y Biologia Molecular, Edificio Santiago Gascon, Campus del Cristo, Universidad de Oviedo, Oviedo, Spain
    Neuroendocrinology 77:162-76. 2003
    ....
  60. ncbi Intercellular calcium waves in cultured enteric glia from neonatal guinea pig
    Weizhen Zhang
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Glia 42:252-62. 2003
    ....
  61. ncbi Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal
    Yuki Hashimotodani
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    Neuron 45:257-68. 2005
    ..We therefore conclude that PLCbeta1 serves as a coincidence detector through its Ca(2+) dependency for endocannabinoid release in hippocampal neurons...
  62. ncbi Mechanism and role of high-potassium-induced reduction of intracellular Ca2+ concentration in rat osteoclasts
    Hiroshi Kajiya
    Department of Physiological Science and Molecular Biology, Fukuoka Dental College, 2 15 1 Tamura, Sawara ku, Fukuoka 814 0193, Japan
    Am J Physiol Cell Physiol 285:C457-66. 2003
    ..Changes in membrane potential regulate osteoclastic motility by controlling the net amount of Ca2+ entry in a "reversed" voltage-dependent manner, i.e., depolarization decreases and hyperpolarization increases [Ca2+]i...
  63. ncbi Intracellular Cs+ activates the PKA pathway, revealing a fast, reversible, Ca2+-dependent inactivation of L-type Ca2+ current
    Fabien Brette
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 6542, Universite de Tours, France
    Am J Physiol Cell Physiol 285:C310-8. 2003
    ..Cs+ seems to activate the cAMP-dependent protein kinase pathway when used as a substitute for K+ in the pipette solution...
  64. ncbi A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes
    Jun Ishikawa
    Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
    J Immunol 170:4441-9. 2003
    ..Furthermore, YM-58483 would be a candidate for the study of capacitative Ca(2+) entry mechanisms through SOC/CRAC channels and for identification of putative Ca(2+) channel genes...
  65. ncbi Intracellular calcium measurements as a method in studies on activity of purinergic P2X receptor channels
    Mu Lan He
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    Am J Physiol Cell Physiol 285:C467-79. 2003
    ....
  66. ncbi Phosphatidylinositol 3-kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation
    Larissa Lipskaia
    INSERM U446 IFR 75, Institut de signalisation et innovation thérapeutique, Faculte de Pharmacie, Tour D4, 5 rue JB Clement, 92296 Chatenay Malabry, France
    Circ Res 92:1115-22. 2003
    ..Blockade of the Ca2+-induced Ca2+ release mechanism and dephosphorylation of pCREB contribute but were not sufficient to induce a proliferating phenotype...
  67. pmc Gap junction channels coordinate the propagation of intercellular Ca2+ signals generated by P2Y receptor activation
    S O Suadicani
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Glia 48:217-29. 2004
    ..These data indicate that in 1321N1 cells gap junctional communication provides intercellular integration of Ca(2+) signals generated by P2YR activation, thus coordinating the propagation of intercellular calcium waves...
  68. ncbi Dendritic calcium encodes striatal neuron output during up-states
    Jason N D Kerr
    Unit of Neural Network Physiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 22:1499-512. 2002
    ..We suggest that this conveys information about the contribution of a spiny projection neuron to a basal ganglia output specifically back to the corticostriatal synapses involved in generating these outputs...
  69. ncbi Ca2+ signaling regulated by an ATP-dependent autocrine mechanism in astrocytes
    H Shiga
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan
    Neuroreport 12:2619-22. 2001
    ..These two different Ca2+ cascades are involved in signal transduction and may function separately during intercellular communication...
  70. ncbi Tuning the mechanosensitivity of a BK channel by changing the linker length
    HuCheng Zhao
    Institute of Biomechanics and Medical Engineering, Tsinghua University, Beijing 100084, PR China
    Cell Res 18:871-8. 2008
    ..Our results are consistent with the idea that membrane stretch is transferred to the gate via the linker-gating ring complex of the MS BK channels...
  71. ncbi Atypical neuroleptic drugs downregulate dopamine sensitivity in rat cortical and striatal astrocytes
    B Reuss
    Neuroanatomy and Interdisciplinary Center for Neurosciences (IZN, University of Heidelberg, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany
    Mol Cell Neurosci 18:197-209. 2001
    ....
  72. ncbi Glutamate pretreatment affects Ca2+ signaling in processes of astrocyte pairs
    Ragunathan Padmashri
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
    J Neurochem 100:105-17. 2007
    ....
  73. pmc Glutamate-mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR-induced release of Ca++ from intracellular stores and is prevented by estradiol
    Genell D Hilton
    Department of Physiology, University of Maryland, Baltimore, Maryland 21201, USA
    Eur J Neurosci 24:3008-16. 2006
    ....
  74. ncbi Beta-amyloid enhances intracellular calcium rises mediated by repeated activation of intracellular calcium stores and nicotinic receptors in acutely dissociated rat basal forebrain neurons
    James H Chin
    Department of Medicine, Division of Neurology, University of Alberta, 530 Heritage Medical Research Centre, Edmonton, AB, Canada T6G 2S2
    Brain Cell Biol 35:173-86. 2006
    ....
  75. ncbi PLC-dependent intracellular Ca2+ release was associated with C6-ceramide-induced inhibition of Na+ current in rat granule cells
    Zheng Liu
    Institute of Brain Science, School of Life Sciences, Fudan University, Shanghai, PR China
    J Neurochem 106:2463-75. 2008
    ....
  76. ncbi Activator protein-1 responsive to the group II metabotropic glutamate receptor subtype in association with intracellular calcium in cultured rat cortical neurons
    Chie Sugiyama
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
    Neurochem Int 51:467-75. 2007
    ..These results suggest that activation of the group II mGluR subtype would modulate the gene expression mediated by AP1 through increased intracellular Ca(2+) levels in cultured rat cortical neurons...
  77. pmc Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation
    Kirk E Dineley
    Department of Biology, Francis Marion University, Florence, SC, USA
    J Neurochem 106:2184-93. 2008
    ..We conclude that glutamate-induced [Zn(2+)](i) transients are caused in part by [Ca(2+)](i)-induced reactive oxygen species that arises from both cytosolic and mitochondrial sources...
  78. ncbi Microtubule disruption by colchicine reversibly enhances calcium signaling in intact rat cardiac myocytes
    B G Kerfant
    Physiopathologie Cardiovasculaire, INSERM U-390, Montpellier, France
    Circ Res 88:E59-65. 2001
    ..In summary, we demonstrate that microtubule disruption by colchicine reversibly modulates Ca(2+) signaling in cardiac cells with intact sarcolemma...
  79. ncbi Reverse mode Na+/Ca2+ exchangers trigger the release of Ca2+ from intracellular Ca2+ stores in cultured rat embryonic cortical neurons
    Meng Pei Wu
    Institute of Zoology, Department of Life Science, National Taiwan University, Taipei, Taiwan, ROC
    Brain Res 1201:41-51. 2008
    ....
  80. ncbi Comparison of intracellular calcium signals evoked by heat and capsaicin in cultured rat dorsal root ganglion neurons and in a cell line expressing the rat vanilloid receptor, VR1
    J R Savidge
    Novartis Institute for Medical Sciences, 5 Gower Place, WC1E 6BN, London, UK
    Neuroscience 102:177-84. 2001
    ....
  81. ncbi Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures
    H Tanaka
    Department of Neurology, Tokyo Medical and Dental University School of Medicine, Japan
    J Muscle Res Cell Motil 21:507-26. 2000
    ....
  82. ncbi Altered cardiac sarcoplasmic reticulum function of intact myocytes of rat ventricle during metabolic inhibition
    C L Overend
    Department of Medicine, University of Manchester, Manchester, UK
    Circ Res 88:181-7. 2001
    ..In the context of ischemia, this extra accumulation of Ca(2+) would present a risk of potentially arrhythmogenic, spontaneous release of Ca(2+) on reperfusion of the tissue...
  83. ncbi Ca2+ flux and signaling implications by nicotinic acetylcholine receptors in rat medial habenula
    Xiaochuan Guo
    Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham, 1825 University Boulevard, Birmingham AL 35294 2182, USA
    J Neurophysiol 97:83-92. 2007
    ....
  84. ncbi Bidirectional Ca2+ coupling of mitochondria with the endoplasmic reticulum and regulation of multimodal Ca2+ entries in rat brown adipocytes
    Masako Kuba
    Laboratory of Anatomy and Physiology, School of Nutritional Sciences, Nagoya Univ of Arts and Sciences, 57 Takenoyama, Iwasaki cho, Nissin, Aichi 470 0196, Japan
    Am J Physiol Cell Physiol 292:C896-908. 2007
    ....
  85. ncbi No evidence for bradykinin B1 receptors in rat dorsal root ganglion neurons
    M Brand
    Institute of Physiology, , , , Germany
    Neuroreport 12:3165-8. 2001
    ..Normal external solution applied at this flow rate constituted a mechanical stimulus causing a response in some neurons. Thus, in comparable set-ups mechanosensitivity has first to be tested to avoid masking effects...
  86. ncbi Odorant receptors directly activate phospholipase C/inositol-1,4,5-trisphosphate coupled to calcium influx in Odora cells
    Guang Liu
    Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Neurochem 96:1591-605. 2006
    ..Thus, individual ORs are capable of elevating calcium through pathways not directly mediated by cAMP and this may provide another avenue for odorant signaling in the olfactory system...
  87. ncbi Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes
    Lixia Zhao
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    Brain Res 943:117-31. 2002
    ..To our knowledge, this is the first documentation of a vasopressin receptor-induced calcium signaling cascade in cortical astrocytes and the first documentation of vasopressin receptor induction of nuclear calcium signaling...
  88. ncbi Effects of 17beta-estradiol on intracellular calcium changes and neuronal survival after mechanical strain injury in neuronal-glial cultures
    Saitida Lapanantasin
    Department of Anatomy and Center for Neuroscience, Faculty of Science, Mahidol University, Bangkok, Thailand
    Synapse 60:406-10. 2006
    ..These results demonstrate the neuroprotective activity of E2 in an in vitro model of neuronal injury, and suggest that such effects may be related to the ability of E2 to modulate [Ca(2+)](i)...
  89. pmc Effects of intracellular and extracellular concentrations of Ca2+, K+, and Cl- on the Na+-dependent Mg2+ efflux in rat ventricular myocytes
    Michiko Tashiro
    Department of Physiology, Tokyo Medical University, Tokyo, Japan
    Biophys J 91:244-54. 2006
    ..2%, n=8); and 3), extracellular and intracellular perfusion with K+-free and Cl--free solutions (71.6+/-5.1%, n=5). These results suggest that Mg2+ is transported in exchange with Na+, but not with Ca2+, K+, or Cl-, in cardiac myocytes...
  90. ncbi Dual role of calbindin-D28K in vesicular catecholamine release from mouse chromaffin cells
    R H S Westerink
    Cellular and Molecular Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    J Neurochem 99:628-40. 2006
    ..Consequently, the possibility that calbindin-D(28K) functions not only as a Ca(2+) buffer but also as a modulator of vesicular catecholamine release is discussed...
  91. ncbi Neuroendocrine mechanisms during reversible hypovolaemic shock in humans with emphasis on the histaminergic and serotonergic system
    S H Matzen
    Department of Medical Physiology, Panum Institute, Denmark
    Acta Physiol Scand Suppl 628:1-31. 1995
    ..extracellular fluid only, changing more than the high frequency current that passes extra as well as intracellular fluid. Central hypovolaemia was found to stimulate the pituitary-adrenal axis, and the development of hypotension ..
  92. ncbi Electrolytes and trace elements in human breast cyst fluid
    Ali Riza Sisman
    Department of Biochemistry, Faculty of Medicine, Dokuz Eylul University, Inciralti, Izmir, Turkey
    Biol Trace Elem Res 128:18-30. 2009
    ..Type I cysts contain fluid with an electrolyte composition similar to that of intracellular fluid (Na/K ratio <3), whereas type II cysts fluid's content resembles that of plasma (Na/K ratio >3)...
  93. ncbi Compulsory hyperventilation and hypocapnia of patients with Leigh syndrome associated with SURF1 gene mutations as a cause of low serum bicarbonates
    E Pronicka
    Department of Metabolic Diseases, Children s Memorial Health Institute, Warsaw, Poland
    J Inherit Metab Dis 24:707-14. 2001
    ..Acidification of intracellular fluid by accumulation of lactate may compensate the effect of respiratory alkalosis...
  94. ncbi Fluid volume control during short-term space flight and implications for human performance
    D E Watenpaugh
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Exp Biol 204:3209-15. 2001
    ..Extracellular fluid volume decreases by 10-15% in microgravity, and intracellular fluid volume appears to increase. Total red blood cell mass decreases by approximately 10% within 1 week in space...
  95. ncbi Water and the cytoskeleton
    J F Leterrier
    UMR CNRS 6558, University of Poitiers, France
    Cell Mol Biol (Noisy-le-grand) 47:901-23. 2001
    The diffusion of intracellular fluid and solutes is mainly limited by the density and the geometry of crossbridges between cytoskeletal polymers mediating the formation of an integrated cytoplasmic scaffold...
  96. ncbi [Hyperkalemias]
    J Rado
    Nephrologia Hypertonia Osztály, Uzsoki utcai Kórház, Budapest
    Orv Hetil 140:2611-8. 1999
    ..K] intake and output) as well as the "internal balance" (distribution of K in the extracellular and intracellular fluid compartments). Factors playing a role in it are: the upright posture, physical activity and hyperosmolality...
  97. ncbi Epithelial magnesium transport and regulation by the kidney
    G A Quamme
    Department of Medicine, University of British Columbia, Vancouver, BC Canada
    Front Biosci 5:D694-711. 2000
    Magnesium is the fourth most abundant cation in the body and the second most common cation in the intracellular fluid. It is the kidney that provides the most sensitive control for magnesium balance...
  98. ncbi Pathomechanisms of cystoid macular edema
    Andreas Bringmann
    Department of Ophthalmology, Eye Clinic, University of Leipzig, Germany
    Ophthalmic Res 36:241-9. 2004
    ..CME) is a well-known endpoint of various ocular diseases, but the relative pathogenic impact of extra- and intracellular fluid accumulation within the retinal tissue still remains uncertain...
  99. ncbi Effect of water phase salt content and storage temperature on Listeria monocytogenes survival in chum salmon (Oncorhynchus keta) roe and caviar (ikura)
    Joong Han Shin
    Dept of Food Science and Human Nutrition, Washington State Univ, Pullman, WA 99164 6376, USA
    J Food Sci 72:M160-5. 2007
    ..Components in the salmon egg intracellular fluid appear to inhibit the growth of L. monocytogenes...
  100. pmc Acute effects of sodium ingestion on thirst and cardiovascular function
    Nina S Stachenfeld
    The John B Pierce Laboratory and Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Curr Sports Med Rep 7:S7-13. 2008
    ..water is used to replenish body water, plasma volume is preferentially restored over the interstitial and intracellular fluid space, suppressing plasma sodium concentration and removing the dipsogenic drive long before total body ..
  101. ncbi Bioimpedance spectroscopy technique: intra-, extracellular, and total body water
    L E Armstrong
    University of Connecticut, Department of Physiology and Neurobiology, Storrs 06269 1110, USA
    Med Sci Sports Exerc 29:1657-63. 1997
    ..frequency bioimpedance spectroscopy (BIS) technique that estimates extracellular fluid volume (ECV), intracellular fluid volume (ICV), and total body water (TBW)...

Research Grants66

  1. Measuring Intra/Extracellular Volume and Hemodynamics
    Leslie Montgomery; Fiscal Year: 2003
    ..Swept frequency bioimpedance by EIS has been used to estimate intravascular, interstitial and intracellular fluid volumes...
  2. THE CARDIAC RESPONSE TO CHRONIC METABOLIC ACIDOSIS
    JOHN BETTICE; Fiscal Year: 1980
    ..has been linked to a fall in the intracellular pH and to changes in the electrolyte composition of the intracellular fluid of the heart...
  3. MANAGEMENT OF COMPARTMENT SYNDROME WITH ULTRAFILTRATION
    WILLIAM FOWLER; Fiscal Year: 2002
    ..an innovative use of tissue ultrafiltration (UF) to reduce tissue pressure by removing interstitial and/or intracellular fluid volume, and to use the increased fluid levels of metabolites to improve diagnosis...
  4. Exploring Growth Energy Expenditure in Normal-Weight and Overweight Children
    ZiMian Wang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  5. MICELLAR CARRIERS FOR SPARINGLY SOLUBLE PHARMACEUTICALS
    Vladimir Torchilin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. TRAINING IN MOLECULAR NEUROBIOLOGY
    William Catterall; Fiscal Year: 2008
    ..The training program will integrate the substantial expertise of this group of faculty in a coordinated pre-doctoral and post-doctoral training effort. ..
  7. Genetic analysis of C. elegans cellular ormoregulation
    Kevin Strange; Fiscal Year: 2004
    ..elegans will likely provide unique insights into osmoregulation, signaling mechanisms, and cellular stress and damage repair )rocesses in kidney cells as well as other mammalian cell types and tissues. ..
  8. MICELLAR CARRIERS FOR SPARINGLY SOLUBLE PHARMACEUTICALS
    Vladimir Torchilin; Fiscal Year: 2002
    ..abstract_text> ..
  9. Culture of differentiated C elegans embryonic cells
    Kevin Strange; Fiscal Year: 2002
    ..The speed and economy with which this can be done in C. elegans cannot be duplicated in other metazoan animals. ..
  10. Fifth International Nanomedicine and Drug Delivery
    Vladimir Torchilin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. Synaptic Alterations in the Cerebral Cortex during Aging
    A Cuello; Fiscal Year: 2005
    ..abstract_text> ..
  12. Effects of intracellular angiotensin II
    Julia Cook; Fiscal Year: 2009
    ..abstract_text> ..
  13. Long-Circulating Polymer-Modified Liposomes
    Vladimir Torchilin; Fiscal Year: 2008
    ..abstract_text> ..
  14. CYROBIOLOGICAL PRESERVATION OF ANOPHELES EMBRYOS
    Peter Mazur; Fiscal Year: 2001
    ..Such a mutant has been isolated in a related species, Anopheles quadrimaculatus. We also propose to collaborate with the Laboratory of Parasitic Diseases at NIH in the cryopreservation of A gambiae larvae. ..
  15. MULTIFUNCTIONAL STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERS
    Vladimir P Torchilin; Fiscal Year: 2010
    ....
  16. ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGING
    Vladimir Torchilin; Fiscal Year: 2006
    ..abstract_text> ..
  17. Mechanisms and use of antidiabetic agents in brain aging and Alzheimer's disease
    Olivier Thibault; Fiscal Year: 2008
    ..Furthermore, these studies will contribute to future drug discovery efforts to generate new TZD-derived or similar drugs for the treatment of AD. [unreadable] [unreadable] [unreadable]..
  18. Antioxidant vitamins in models of Alzheimer's Disease
    James May; Fiscal Year: 2008
    ..If antioxidant vitamins ameliorate toxicity in cell and animal models of Alzheimer's disease, then oxidant stress is involved in disease progression, and antioxidant vitamin supplements may be beneficial. ..
  19. Structure/Function of Peroxisomes in Neuroinflammation
    Inderjit Singh; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  20. Kinase-phosphatase complex in transducing pain signals
    Xian Min Yu; Fiscal Year: 2008
    ..No such studies have yet been conducted in Vc, and so the proposed research promises to reveal novel molecular networks involved in the regulation of orofacial pain. [unreadable] [unreadable]..
  21. Liberation of Intracellular Zinc and Neuronal Cell Death
    Elias Aizenman; Fiscal Year: 2007
    ..With this information, we hope to uncover novel therapeutic strategies to prevent or halt the progression of these and other neurodegenerative conditions. ..
  22. Structural Studies of the Innate Immune Pathway
    MICHAEL LASKER; Fiscal Year: 2008
    ....
  23. 2008 Calcium Signaling and Disease SGP Conference
    Ilya Bezprozvanny; Fiscal Year: 2008
    ..The major purpose of the SGP is to host a symposium each year on a different subject of wide interest to cell biologists, physiologists and biophysicists. [unreadable] [unreadable] [unreadable]..
  24. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  25. Chemokines in pathogenesis of Experimental Arthritis
    SEEMA SINGH AHUJA; Fiscal Year: 2010
    ..Thus information obtained from proposed studies which explore how CCR2 modulates arthritis will have significant impact on potential therapeutic strategies to treat this chronic deblitating disease. ..
  26. Gating of Neuronal Kv4 Channels
    MANUEL L COVARRUBIAS; Fiscal Year: 2010
    ..This work is likely to impact the stud of neurological entities possibly linked to the Kv4 channel complex, such as epilepsy, pain plasticity, neur egenerative disorders, and autism. ..
  27. IL-6 Regulation of Hippocampal Synaptic Function
    Donna L Gruol; Fiscal Year: 2010
    ..The proposed studies focus on this issue as it relates to CNS disorders. ..
  28. Lipid Raft Microdomains in Neutrophil Function
    ROBERT GARY SITRIN; Fiscal Year: 2010
    ..Hopefully, targeting the function of lipid raft microdomains will engender new therapeutic strategies for enhancing antimicrobial defenses and suppressing the deleterious effects of acute inflammation. ..
  29. Mechanism of Nicotine Action in the Healing Skeleton
    Michael Zuscik; Fiscal Year: 2009
    ....
  30. Mechanisms of activation of vagal afferent neurons
    Steven Simasko; Fiscal Year: 2009
    ..A better appreciation of this important signaling pathway will contribute to the understanding of energy homeostasis and GI function, and aid in the design of therapeutic interventions for better health. ..
  31. Regulation of Cx43 by Src and Novel Interacting Proteins
    Alan Lau; Fiscal Year: 2009
    ....
  32. A Novel Inhibitor of Stat3 for Prostate Cancer Therapy
    Naijie Jing; Fiscal Year: 2009
    ..abstract_text> ..
  33. SHEAR STRESS EFFECTS ON ENDOTHELIAL TRANSPORT
    John M Tarbell; Fiscal Year: 2010
    ..abstract_text> ..
  34. Lipid Transport-Connecting Fundamental Membrane Assembly To Human Disease
    DENNIS VOELKER; Fiscal Year: 2008
    ..7. Project Narrative N/A [unreadable] [unreadable] [unreadable]..
  35. NONINVASIVE MEASUREMENT OF ENERGY EXPENDITURE IN HUMANS
    Dale Schoeller; Fiscal Year: 2007
    ..These studies will provide important guidelines for the prescription of exercise for the prevention and treatment of obesity. ..
  36. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2008
    ....
  37. DEVELOPMENTAL CIRCUITS IN GASTRULATION AND NEURULATION
    Marc Kirschner; Fiscal Year: 2008
    ..Our major approach here is to examine the early embryology of the acorn worm, Saccoglossus kowalevskii, and identify genes which in vertebrates play a major role in the Organizer. ..
  38. Antioxidant Functions of Lipoic Acid
    James May; Fiscal Year: 2004
    ..Despite the widespread use of lipoic acid, these studies are necessary to establish the biological basis and rationale for the clinical use of the agent. ..
  39. Meeting of American Society for Reproductive Immunology:
    Gil Mor; Fiscal Year: 2003
    ..abstract_text> ..
  40. MOLECULAR ANALYSIS OF GLP-1 RECEPTOR ACTIVATION
    Martin Beinborn; Fiscal Year: 2003
    ..Receptor will be expressed in cell lines derived from beta cells and its ability to modulate cAMP levels in the absence of ligands evaluated. ..
  41. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ....
  42. DYNAMICS OF CALMODULIN IN NEURONS
    SALLY KIM; Fiscal Year: 2003
    ..These studies will provide essential information for understanding how neurons process information through the Ca2+/calmodulin-dependent signaling pathway. ..
  43. WALL SHEAR STRESS IN THE CARDIOVASCULAR SYSTEM
    JOHN TARBELL; Fiscal Year: 2003
    ....
  44. BEHAVIORAL AND VIROLOGIC FEATURES OF HIV+ IDUS IN CHINA
    Xiao Fang Yu; Fiscal Year: 2002
    ..These aims will be carried out in Guangxi Province through a longitudinal investigation of 600 drug users about whom demographic, social, and drug use information will be collected and analyzed. ..
  45. DEVELOPING A POTENT INHIBITOR OF HIV-I INTEGRASE
    Naijie Jing; Fiscal Year: 2001
    ....
  46. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..
  47. EVALUATION OF HIV GAG DNA VACCINE TO MAX T HELPER/CTL
    Xiao Fang Yu; Fiscal Year: 2001
    ..C) Combination studies by using DNA vectors identified from this specific aim with DNA vectors identified from specific aim 1. ..
  48. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2004
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  49. NEURONAL ACTIONS OF HOST FACTORS IN NEUROAIDS
    DONNA GRUOL; Fiscal Year: 2005
    ..The overall design will address effects of both acute and chronic chemokine exposure on neuronal cell function and will include examination of two distinct classes of neurons, excitatory glutamatergic and inhibitory GABAergic neurons. ..
  50. Multiplex arrays using Confocal Raman for BRCA1 alternative splice profiling
    Joseph Irudayaraj; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Modulating IBM pathology in transgenic mice
    Frank LaFerla; Fiscal Year: 2005
    ....
  52. Role of prion protein in neuronal survival
    Andrea LeBlanc; Fiscal Year: 2006
    ..The result of these experiments will clearly define the neuroprotective role of PrP against Bax mediated cell death. ..
  53. Mechanisms of Alcohol Effects on Sleep
    Steven Simasko; Fiscal Year: 2006
    ..Such interventions could prove to be a useful adjunct to treat recovering alcoholics since prolonged sleep disturbances are a predicting factor for relapse into drinking behavior. ..
  54. Investigation of Human Muscle Function in vivo
    BRUCE DAMON; Fiscal Year: 2005
    ..In this application we have requested partial support for the trainees to attend and benefit from the workshop; we have also requested support for a minority trainee travel stipend program...
  55. Quantifying Oxidative Metabolism in Diabetic Muscle
    BRUCE DAMON; Fiscal Year: 2005
    ..Moreover, these techniques will be suitable for future studies of the effects of exercise training or other interventions in diabetic animal models. ..
  56. Effect of Pertussis Toxin on Cough in Guinea Pig
    NICHOLAS CARBONETTI; Fiscal Year: 2005
    ..abstract_text> ..
  57. Magnex Model MRBR 7T/201 AS Shielded Magnet System
    Jean Philippe Galons; Fiscal Year: 2005
    ..7 Tesla platform. Therefore, the need to acquire new imaging capabilities and the growth of the UoA MRI imaging community are the main justification for the present request. ..
  58. LASER DOPPLER VELOCIMETER SYSTEM FOR BIOMEDICAL STUDIES
    JOHN TARBELL; Fiscal Year: 2001
    ..The system will be the primary measurement system for the ongoing research in cardiovascular prosthetics including mechanical heart valve cavitation and ventricular assist devices. ..
  59. Mechanisms Underlying the Cognitive Function of Sleep
    Subimal Datta; Fiscal Year: 2009
    ....
  60. Regulation of calcium signaling pathways by presenilins
    Frank LaFerla; Fiscal Year: 2005
    ..Lastly, by manipulating calcium signaling and determining its effects on AB production, aim 5 will address whether the effects of presenilin mutations on calcium signaling are necessary and/or sufficient to increase Ab formation. ..
  61. Regulation of CART Expression in Rat Nucleus Accumbens
    Douglas Jones; Fiscal Year: 2007
    ..abstract_text> ..
  62. Studies of Diacylglycerol-Binding Proteins
    Wonhwa Cho; Fiscal Year: 2009
    ....
  63. INNER RETINAL CONTRIBUTIONS TO THE ERG
    Bret Hughes; Fiscal Year: 2003
    ....