cerebrospinal fluid

Summary

Top Publications

  1. ncbi The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics
    P Zamboni
    Vascular Diseases Center, University of Ferrera, and Bellaria Neurosciences, Ferrara and Bologna, Italy
    Funct Neurol 24:133-8. 2009
  2. doi Recent insights into a new hydrodynamics of the cerebrospinal fluid
    Marin Bulat
    University of Zagreb School of Medicine, Department of Pharmacology and Croatian Institute for Brain Research, 10 000 Zagreb, Croatia
    Brain Res Rev 65:99-112. 2011
  3. doi The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction
    Britta Engelhardt
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, 3012, Bern, Switzerland
    Semin Immunopathol 31:497-511. 2009
  4. doi Venous and cerebrospinal fluid flow in multiple sclerosis: a case-control study
    Peter Sundström
    Department of Clinical Neuroscience, Umea University, Sweden
    Ann Neurol 68:255-9. 2010
  5. pmc The cerebrospinal fluid provides a proliferative niche for neural progenitor cells
    Maria K Lehtinen
    Division of Genetics, Howard Hughes Medical Institute, Children s Hospital Boston, Boston, MA 02115, USA
    Neuron 69:893-905. 2011
  6. doi The formation of cerebrospinal fluid: nearly a hundred years of interpretations and misinterpretations
    D Oreskovic
    Rudjer Boskovic Institute, Department of Molecular Biology, Bijenicka 54, Zagreb, Croatia
    Brain Res Rev 64:241-62. 2010
  7. ncbi Molecular epidemiological analysis of Japanese encephalitis virus in China
    Huan Yu Wang
    State Key Laboratory for Infectious Disease Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 100 YingXinJie, XuanWuQu, Beijing 100052, People s Republic of China
    J Gen Virol 88:885-94. 2007
  8. pmc Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection
    Tricia H Burdo
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    AIDS 27:1387-95. 2013
  9. doi Cine cerebrospinal fluid imaging in multiple sclerosis
    Christopher Magnano
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, New York, USA
    J Magn Reson Imaging 36:825-34. 2012
  10. doi Development of hydrocephalus and classical hypothesis of cerebrospinal fluid hydrodynamics: facts and illusions
    D Oreskovic
    Ruđer Bošković Institute, Department of Molecular Biology, Bijenicka 54, 10 000 Zagreb, Croatia
    Prog Neurobiol 94:238-58. 2011

Detail Information

Publications393 found, 100 shown here

  1. ncbi The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics
    P Zamboni
    Vascular Diseases Center, University of Ferrera, and Bellaria Neurosciences, Ferrara and Bologna, Italy
    Funct Neurol 24:133-8. 2009
    ..the relationship between a Doppler cerebral venous hemodynamic insufficiency severity score (VHISS) and cerebrospinal fluid (CSF) flow dynamics in 16 patients presenting with CCSVI and relapsing-remitting MS (CCSVI-MS) and in eight ..
  2. doi Recent insights into a new hydrodynamics of the cerebrospinal fluid
    Marin Bulat
    University of Zagreb School of Medicine, Department of Pharmacology and Croatian Institute for Brain Research, 10 000 Zagreb, Croatia
    Brain Res Rev 65:99-112. 2011
    According to the traditional hypothesis, the cerebrospinal fluid (CSF) is secreted inside the brain ventricles and flows unidirectionally along subarachnoid spaces to be absorbed into venous sinuses across arachnoid villi and/or via ..
  3. doi The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction
    Britta Engelhardt
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, 3012, Bern, Switzerland
    Semin Immunopathol 31:497-511. 2009
    ..CNS) is tightly sealed from the changeable milieu of blood by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB)...
  4. doi Venous and cerebrospinal fluid flow in multiple sclerosis: a case-control study
    Peter Sundström
    Department of Clinical Neuroscience, Umea University, Sweden
    Ann Neurol 68:255-9. 2010
    ..We found no differences regarding internal jugular venous outflow, aqueductal cerebrospinal fluid flow, or the presence of internal jugular blood reflux...
  5. pmc The cerebrospinal fluid provides a proliferative niche for neural progenitor cells
    Maria K Lehtinen
    Division of Genetics, Howard Hughes Medical Institute, Children s Hospital Boston, Boston, MA 02115, USA
    Neuron 69:893-905. 2011
    ..We found that the cerebrospinal fluid (CSF), which contacts this apical domain, has an age-dependent effect on proliferation, much of which is ..
  6. doi The formation of cerebrospinal fluid: nearly a hundred years of interpretations and misinterpretations
    D Oreskovic
    Rudjer Boskovic Institute, Department of Molecular Biology, Bijenicka 54, Zagreb, Croatia
    Brain Res Rev 64:241-62. 2010
    The first scientific and experimental approaches to the study of cerebrospinal fluid (CSF) formation began almost a hundred years ago...
  7. ncbi Molecular epidemiological analysis of Japanese encephalitis virus in China
    Huan Yu Wang
    State Key Laboratory for Infectious Disease Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 100 YingXinJie, XuanWuQu, Beijing 100052, People s Republic of China
    J Gen Virol 88:885-94. 2007
    Sixty-two new Japanese encephalitis virus (JEV) isolates were obtained from mosquitoes, biting midges, human cerebrospinal fluid and human blood samples in China during 2002-2005...
  8. pmc Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection
    Tricia H Burdo
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    AIDS 27:1387-95. 2013
    ....
  9. doi Cine cerebrospinal fluid imaging in multiple sclerosis
    Christopher Magnano
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, New York, USA
    J Magn Reson Imaging 36:825-34. 2012
    To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius in multiple sclerosis (MS) patients and healthy controls (HC) using cine phase contrast imaging.
  10. doi Development of hydrocephalus and classical hypothesis of cerebrospinal fluid hydrodynamics: facts and illusions
    D Oreskovic
    Ruđer Bošković Institute, Department of Molecular Biology, Bijenicka 54, 10 000 Zagreb, Croatia
    Prog Neurobiol 94:238-58. 2011
    According to the classical hypothesis of the cerebrospinal fluid (CSF) hydrodynamics, CSF is produced inside the brain ventricles, than it circulates like a slow river toward the cortical subarachnoid space, and finally it is absorbed ..
  11. pmc Polar invasion and translocation of Neisseria meningitidis and Streptococcus suis in a novel human model of the blood-cerebrospinal fluid barrier
    Christian Schwerk
    Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    PLoS ONE 7:e30069. 2012
    ..Discussed as entry sites for pathogens into the brain are the blood-brain and the blood-cerebrospinal fluid barrier (BCSFB)...
  12. pmc Discriminating Lyme neuroborreliosis from other neuroinflammatory diseases by levels of CXCL13 in cerebrospinal fluid
    N D van Burgel
    Department of Medical Microbiology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, Netherlands
    J Clin Microbiol 49:2027-30. 2011
    CXCL13 in cerebrospinal fluid (CSF) could be an important component for diagnosing Lyme neuroborreliosis (LNB)...
  13. ncbi Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial
    Annemarie E Brouwer
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 363:1764-7. 2004
    It frequently takes more than 2 weeks for drug treatments for cryptococcal meningitis to sterilise cerebrospinal fluid (CSF)...
  14. pmc Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis
    Anthony Lee
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Infect Immun 78:4213-25. 2010
    ..various microenvironments during growth in the mammalian host, including intracellular vacuoles, blood, and cerebrospinal fluid (CSF)...
  15. pmc Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin
    Pia Kivisakk
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195 Millennium Pharmaceuticals, Inc, Cambridge, MA 02142
    Proc Natl Acad Sci U S A 100:8389-94. 2003
    b>Cerebrospinal fluid (CSF) from healthy individuals contains between 1,000 and 3,000 leukocytes per ml. Little is known about trafficking patterns of leukocytes between the systemic circulation and the noninflamed CNS...
  16. doi Evaluation of transplantation of autologous bone marrow stromal cells into the cerebrospinal fluid for treatment of chronic spinal cord injury in dogs
    Hidetaka Nishida
    Nakayama Veterinary Hospital, 6 1 Minamifukuro, Nara, Nara, 630 8106, Japan
    Am J Vet Res 72:1118-23. 2011
    ..To evaluate effects of transplantation of bone marrow stromal cells (BMSCs) into the CSF for the treatment of chronic spinal cord injury in dogs that had not responded by 1 month after decompressive surgery...
  17. ncbi Cerebrospinal fluid concentrations of anti-inflammatory mediators in early-phase severe traumatic brain injury
    Tadahiko Shiozaki
    Department of Traumatology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Shock 23:406-10. 2005
    ..severe traumatic brain injury (TBI), the anti-inflammatory interleukin (IL)-10 concentration was lower in cerebrospinal fluid (CSF) than in serum, whereas proinflammatory IL-1beta and tumor necrosis factor (TNF)-alpha concentrations ..
  18. doi Effect of antibiotic pretreatment on cerebrospinal fluid profiles of children with bacterial meningitis
    Lise E Nigrovic
    Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Pediatrics 122:726-30. 2008
    The goal of this study was to evaluate the effect of antibiotic administration before lumbar puncture on cerebrospinal fluid profiles in children with bacterial meningitis.
  19. pmc Neurogenesis at the brain-cerebrospinal fluid interface
    Maria K Lehtinen
    Division of Genetics, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 27:653-79. 2011
    ..Recent research shows that the cerebrospinal fluid, which contacts apical progenitors at the ventricular surface and bathes the apical complex of these cells, ..
  20. pmc Identification and proteomic profiling of exosomes in human cerebrospinal fluid
    Jonathan M Street
    University British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    J Transl Med 10:5. 2012
    ..Although studied in several biofluids, exosomes have not been extensively studied in the cerebrospinal fluid (CSF) from humans...
  21. doi How to shorten patient follow-up after treatment for Trypanosoma brucei gambiense sleeping sickness
    Dieudonné Mumba Ngoyi
    Department of Parasitology, Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo
    J Infect Dis 201:453-63. 2010
    ..At each follow-up visit, cerebrospinal fluid (CSF) is examined for trypanosomes and white blood cells (WBCs)...
  22. doi The blood-cerebrospinal fluid barrier: structure and functional significance
    Conrad E Johanson
    Department of Clinical Neuroscience, Alpert Medical School at Brown University, Providence, RI, USA
    Methods Mol Biol 686:101-31. 2011
    ..Steady-state concentration ratios, CSF/plasma, ranging from 0.003 for IgG to 0.80 for urea, provide insight on plasma solute penetrability, barrier permeability, and CSF sink action to clear substances from CNS...
  23. ncbi Marked reduction of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhage
    Paul Klimo
    Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132 2303, USA
    J Neurosurg 100:215-24. 2004
    ..to evaluate the effectiveness of a lumbar drain in patients with SAH compared with those in whom an EVD or no form of cerebrospinal fluid (CSF) drainage was used to prevent the development of clinical vasospasm and its sequelae.
  24. doi Efficient diagnosis of tuberculous meningitis by detection of Mycobacterium tuberculosis DNA in cerebrospinal fluid filtrates using PCR
    Sagarika Haldar
    Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    J Med Microbiol 58:616-24. 2009
    ..In view of the paucibacillary nature of cerebrospinal fluid (CSF) and the recent demonstration of free Mycobacterium tuberculosis DNA in clinical specimens, the ..
  25. pmc Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    BMC Infect Dis 10:67. 2010
    ..We performed a retrospective study to determine these findings in a setting of high HIV and TB prevalence in Cape Town...
  26. ncbi Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels
    Marin Bulat
    Department of Pharmacology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia
    Coll Antropol 32:43-50. 2008
    It is generally accepted that volume of cerebrospinal fluid (CSF) is secreted in brain ventricles and flows to subarachnoid space to be absorbed into dural venous sinuses or/and into lymphatics via perineural sheats of cranial nerves...
  27. doi New experimental model of acute aqueductal blockage in cats: effects on cerebrospinal fluid pressure and the size of brain ventricles
    M Klarica
    Department of Pharmacology and Croatian Institute for Brain Research, School of Medicine University of Zagreb, Salata 11, Zagreb, HR 10 000, Croatia
    Neuroscience 158:1397-405. 2009
    It is generally assumed that cerebrospinal fluid (CSF) is secreted in the brain ventricles, and so after an acute blockage of the aqueduct of Sylvius an increase in the ventricular CSF pressure and dilation of isolated ventricles may be ..
  28. ncbi Does the secretion and circulation of the cerebrospinal fluid really exist?
    D Oreskovic
    Laboratory of Neurochemistry and Molecular Neurobiology, Department of Molecular Genetics, Rud er Bosković Institute, Bijenicka 54, Zagreb, HR 10000, Croatia
    Med Hypotheses 56:622-4. 2001
    The secretion and circulation of cerebrospinal fluid have been studied in anaesthetized cats by means of a plastic cannula introduced into the aqueduct of Sylvius and by inspection of free escape of cerebrospinal fluid out of the end of ..
  29. ncbi The formation and circulation of cerebrospinal fluid inside the cat brain ventricles: a fact or an illusion?
    Darko Oreskovic
    Department of Molecular Genetics, Laboratory of Neurochemistry and Molecular Neurobiology, Ruder Boskovic Institute, Bijenicka c 54, Zagreb, Croatia
    Neurosci Lett 327:103-6. 2002
    Formation and circulation of cerebrospinal fluid (CSF) have been studied in the isolated brain ventricles of anesthetized cats by a new approach and under direct observation...
  30. doi Direct venous spinal reabsorption of cerebrospinal fluid: a new concept with serial magnetic resonance cisternography in rabbits
    Huseyin Biceroglu
    Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Neurosurg Spine 16:394-401. 2012
    ..Huge absorptive surface areas of microvessels have been suggested to serve a putative role in reabsorption. The authors' aim was to observe direct venous connections between the subarachnoid space and the perispinal veins...
  31. ncbi Bacterial meningitis caused by the use of ventricular or lumbar cerebrospinal fluid catheters
    Rogier P Schade
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Neurosurg 102:229-34. 2005
    ..In the present study the authors compared the incidence and risk factors for external drainage-related bacterial meningitis (ED-BM) by using ventricular and lumbar catheters...
  32. pmc Combination flucytosine and high-dose fluconazole compared with fluconazole monotherapy for the treatment of cryptococcal meningitis: a randomized trial in Malawi
    Jesse C Nussbaum
    University of North Carolina UNC Project and 2Kamuzu Central Hospital, Lilongwe, Malawi
    Clin Infect Dis 50:338-44. 2010
    ..Fluconazole at a dosage of 1200 mg per day is more fungicidal than at a dosage of 800 mg per day, but mortality rates remain unacceptably high. Therefore, we examined the effect of adding oral flucytosine to fluconazole...
  33. pmc Cerebrospinal fluid and neuroimaging biomarker abnormalities suggest early neurological injury in a subset of individuals during primary HIV infection
    Michael J Peluso
    Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA
    J Infect Dis 207:1703-12. 2013
    b>Cerebrospinal fluid (CSF) and neuroimaging abnormalities demonstrate neuronal injury during chronic AIDS, but data on these biomarkers during primary human immunodeficiency virus (HIV) infection is limited.
  34. pmc Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa
    Matthew Scarborough
    College of Medicine, Blantyre, Malawi
    N Engl J Med 357:2441-50. 2007
    ..Adjuvant therapy with corticosteroids reduces mortality among adults in the developed world, but it has not been adequately tested in developing countries or in the context of advanced human immunodeficiency virus (HIV) infection...
  35. pmc Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
    Anne H Cross
    Box 8111, Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, Saint Louis, MO 63110, USA
    J Neuroimmunol 180:63-70. 2006
    ..Flow cytometry demonstrated reduced cerebrospinal fluid (CSF) B cells and T cells in most patients at 6 months post-treatment...
  36. ncbi Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 6:4433-9. 2007
    ..mass spectrometry method that enables accurate and rapid monitoring of the major Abeta isoforms in cerebrospinal fluid. Furthermore, we describe a technique of antibody immobilization, minimizing background signals...
  37. ncbi Cerebrospinal fluid analysis
    Dean A Seehusen
    Department of Family Practice and Emergency Medical Services, Tripler Army Medical Center, Honolulu, Hawaii, USA
    Am Fam Physician 68:1103-8. 2003
    Lumbar puncture is frequently performed in primary care. Properly interpreted tests can make cerebrospinal fluid (CSF) a key tool in the diagnosis of a variety of diseases...
  38. doi A mathematical model of blood, cerebrospinal fluid and brain dynamics
    Andreas A Linninger
    Laboratory for Product and Process Design LPPD, Department of Bioengineering and Chemical Engineering, University of Illinois at Chicago, Chicago, USA
    J Math Biol 59:729-59. 2009
    ..Blood, cerebrospinal fluid (CSF) and brain parenchyma as well as the spinal canal are included...
  39. pmc Protein analysis in human cerebrospinal fluid: Physiological aspects, current progress and future challenges
    Andreas F Huhmer
    Proteomics, Finnigan Mass Spectrometry, Thermo Electron, San Jose, CA 95134, USA
    Dis Markers 22:3-26. 2006
    ..over 100 years ago marks the beginning of the study of central nervous system diseases using the human cerebrospinal fluid (CSF)...
  40. ncbi Blood-mediated scavenging of cerebrospinal fluid glutamate
    Miroslav Gottlieb
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    J Neurochem 87:119-26. 2003
    ..occurring brain-to-blood Glu efflux was studied using paradigms based on the fate of Glu present in the cerebrospinal fluid or infused into the brain ventricles and monitored before, during, and after decreasing blood Glu levels ..
  41. doi Nosocomial ventriculitis and meningitis in neurocritical care patients
    R Beer
    Neurological Critical Care Unit, Dept of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 255:1617-24. 2008
    ....
  42. doi Primed status of transitional B cells associated with their presence in the cerebrospinal fluid in early phases of multiple sclerosis
    Catalina Lee-Chang
    Université de Lille Nord de France, 1 place de Verdun, Lille Cedex, Lille, France
    Clin Immunol 139:12-20. 2011
    ....
  43. doi Comparison of human parechovirus and enterovirus detection frequencies in cerebrospinal fluid samples collected over a 5-year period in edinburgh: HPeV type 3 identified as the most common picornavirus type
    Heli Harvala
    Specialist Virology Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    J Med Virol 83:889-96. 2011
    ..over a 5-year surveillance period using highly sensitive EV and HPeV PCR assays for screening 4,168 cerebrospinal fluid (CSF) specimens collected from hospitalized individuals between 2005 and 2010 in Edinburgh...
  44. ncbi Glutamine transport at the blood-brain and blood-cerebrospinal fluid barriers
    Jianming Xiang
    Department of Neurosurgery, University of Michigan, R5550 Kresge I, Ann Arbor, MI 48109 0532, USA
    Neurochem Int 43:279-88. 2003
    ..brain, the cerebral capillaries and the choroid plexuses that form the blood-brain barriers (BBB) and blood-cerebrospinal fluid (CSF) barriers, have the potential to influence brain glutamine concentrations...
  45. ncbi Relationship between cerebrospinal fluid and blood dynamics in healthy volunteers and patients with communicating hydrocephalus
    Olivier Baledent
    Department of Imaging and Biophysics, UMR 6600 CNRS, Teaching Hospitals, Jules Verne University of Picardie, Amiens, France
    Invest Radiol 39:45-55. 2004
    Using magnetic resonance imaging (MRI), we investigated cerebral blood and cerebrospinal fluid (CSF) flows in patients with communicating hydrocephalus (CH) and in healthy volunteers to determine the contribution of CSF flow to brain ..
  46. doi Clonal dissemination of human isolates of Streptococcus suis serotype 14 in Thailand
    Anusak Kerdsin
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Tiwanon Road, Muang, Nonthaburi 11000, Thailand
    J Med Microbiol 58:1508-13. 2009
    ..Because serotype 14 is becoming a more common cause of S. suis infections in humans, diagnostic tests for serotype 14 should be performed in South-East Asian countries...
  47. pmc Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens
    W Allan Nix
    Polio and Picornavirus Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:2698-704. 2006
    ..A product of the expected size was successfully amplified and sequenced from cerebrospinal fluid; serum; stool suspensions; and nasopharyngeal, eye, and rectal swab specimens, allowing unambiguous ..
  48. ncbi Proteome analysis of chick embryonic cerebrospinal fluid
    Carolina Parada
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Av Diagonal 645, 08028 Barcelona, Catalonia, Spain
    Proteomics 6:312-20. 2006
    During early stages of embryo development, the brain cavity is filled with embryonic cerebrospinal fluid (E-CSF), a complex fluid containing different protein fractions that contributes to the regulation of the survival, proliferation ..
  49. doi Epithelial pathways in choroid plexus electrolyte transport
    Helle H Damkier
    Department of Anatomy and the Water and Salt Research Center, Aarhus University, Aarhus C, Denmark
    Physiology (Bethesda) 25:239-49. 2010
    ..The choroid plexus epithelium produces the cerebrospinal fluid and in doing so influences the chemical composition of the interstitial fluid of the brain...
  50. pmc Establishing the proteome of normal human cerebrospinal fluid
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    PLoS ONE 5:e10980. 2010
    Knowledge of the entire protein content, the proteome, of normal human cerebrospinal fluid (CSF) would enable insights into neurologic and psychiatric disorders...
  51. ncbi Blood-cerebrospinal fluid barrier and intrathecal immunoglobulins compared to field diagnosis of central nervous system involvement in sleeping sickness
    S Bisser
    Institut d Epidémiologie Neurologique et de Neurologie Tropicale EA3174, Faculte de Medecine, 2 rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France
    J Neurol Sci 193:127-35. 2002
    ..diagnosis is based on white blood cell count, total protein concentration and presence of trypanosomes in cerebrospinal fluid (CSF). More sensitive and specific parameters are now available...
  52. ncbi FGF2 plays a key role in embryonic cerebrospinal fluid trophic properties over chick embryo neuroepithelial stem cells
    C Martin
    Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, C Ramón y Cajal 7, 47005 Valladolid, Spain
    Dev Biol 297:402-16. 2006
    ..another source of FGF2, besides that of the neuroepithelium, which affects the brain primordium, since the cerebrospinal fluid (E-CSF) contains several isoforms of this factor...
  53. ncbi New neurons follow the flow of cerebrospinal fluid in the adult brain
    Kazunobu Sawamoto
    Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California San Francisco, San Francisco, CA 94143, USA
    Science 311:629-32. 2006
    ..over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow...
  54. doi Tumor necrosis factor alpha (TNF-alpha) levels in the brain and cerebrospinal fluid after meningitis induced by Streptococcus pneumoniae
    Tatiana Barichello
    Laboratório de Fisiopatologia Experimental and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pos Graduacao em Ciencias da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil
    Neurosci Lett 467:217-9. 2009
    ..The brain was removed and hippocampus, cortex, prefrontal and cerebrospinal fluid (CSF) were isolated and used for the determination of TNF-alpha levels...
  55. doi Modification of protein transfer across blood/cerebrospinal fluid barrier in response to altered plasma protein composition during development
    S A Liddelow
    Department of Pharmacology, University of Melbourne, Level 9 Medical Sciences Building, Grattan Street, Parkville, Victoria 3010, Australia
    Eur J Neurosci 33:391-400. 2011
    ..cells has previously been proposed to contribute to the characteristically high concentration of protein in cerebrospinal fluid (CSF) in the immature brain...
  56. ncbi Two subsets of dendritic cells are present in human cerebrospinal fluid
    M Pashenkov
    Division of Neurology, Karolinska Institutet, Huddinge University Hospital, R54, SE 14186 Huddinge, Sweden
    Brain 124:480-92. 2001
    ..Myeloid and plasmacytoid dendritic cells in CSF may contribute to orchestration of the local immune responses...
  57. doi Cellular transfer of macromolecules across the developing choroid plexus of Monodelphis domestica
    Shane A Liddelow
    Department of Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Eur J Neurosci 29:253-66. 2009
    Choroid plexus epithelial cells secrete cerebrospinal fluid (CSF) and transfer molecules from blood into CSF...
  58. doi Detection of BK, JC, WU, or KI polyomaviruses in faecal, urine, blood, cerebrospinal fluid and respiratory samples
    Seweryn Bialasiewicz
    Queensland Pediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, QLD, Australia
    J Clin Virol 45:249-54. 2009
    ..The related human polyomaviruses JCV and BKV in contrast, have been detected in a wide range of sample types, leading to increased knowledge about their biology and pathogenesis...
  59. ncbi Porcine Choroid plexus epithelial cells in culture: regulation of barrier properties and transport processes
    M Haselbach
    , , , Germany
    Microsc Res Tech 52:137-52. 2001
    The epithelial cells of the choroid plexus are the structural basis of the blood-cerebrospinal fluid (CSF)-barrier. Here we summarise our recent efforts to culture those cells mainly on permeable supports in vitro...
  60. ncbi Card agglutination test for trypanosomiasis (CATT) end-dilution titer and cerebrospinal fluid cell count as predictors of human African Trypanosomiasis (Trypanosoma brucei gambiense) among serologically suspected individuals in southern Sudan
    Francois Chappuis
    Medecins Sans Frontieres, Swiss Section, Geneva, Switzerland
    Am J Trop Med Hyg 71:313-7. 2004
    ..The cumulative yearly risk was also high (76%) in individuals found with 11-20 cells in the cerebrospinal fluid, but this involved only eight patients. Adjustment for potential confounders did not affect the results...
  61. ncbi MMPs contribute to TNF-alpha-induced alteration of the blood-cerebrospinal fluid barrier in vitro
    Patrick Zeni
    Institut fur Biochemie, Westfalische Wilhelms Universitat, Wilhelm Klemm Strasse 2, D 48149 Munster, Germany
    Am J Physiol Cell Physiol 293:C855-64. 2007
    ..epithelial cells of the choroid plexus separate the central nervous system from the blood forming the blood-cerebrospinal fluid (CSF) barrier...
  62. pmc Detection and analysis of hepatitis C virus sequences in cerebrospinal fluid
    Tomasz Laskus
    Division of Transplantation Medicine, Mayo Clinic, Scottsdale, Arizona 85259, USA
    J Virol 76:10064-8. 2002
    Hepatitis C virus (HCV) sequences were detected in cerebrospinal fluid (CSF) in 8 of 13 HCV-positive patients...
  63. doi Multiple administrations of human marrow stromal cells through cerebrospinal fluid prolong survival in a transgenic mouse model of amyotrophic lateral sclerosis
    Chen Zhang
    Department of Neurology, First Affiliated Hospital of Sun Yat sen University, Guangzhou, Guangdong, corrected PR China
    Cytotherapy 11:299-306. 2009
    ..We investigated the effects of human marrow stromal cells (hMSC) delivered through cerebrospinal fluid (CSF) in a transgenic mouse model of ALS.
  64. ncbi Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue
    Kotaro Satake
    Department of Orthopaedic Surgery, Washington University in St Louis, MO 63110, USA
    Spine (Phila Pa 1976) 29:1971-9. 2004
    ..Experimental spinal cord injury using a rat model...
  65. ncbi The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type
    G D Silverberg
    Department of Neurosurgery, Stanford University School of Medicine, CA 94305 5327, USA
    Neurology 57:1763-6. 2001
    ..To evaluate the production rate of CSF in patients with differing disease states...
  66. ncbi Analysis of potential diagnostic biomarkers in cerebrospinal fluid of idiopathic normal pressure hydrocephalus by proteomics
    X Li
    Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan
    Acta Neurochir (Wien) 148:859-64; discussion 864. 2006
    ..The present study investigated the disease-specific proteins that aid in the diagnosis and treatment of INPH and thus to study their role in the disease process...
  67. pmc Options for field diagnosis of human african trypanosomiasis
    Francois Chappuis
    Travel and Migration Medicine Unit, Geneva University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Clin Microbiol Rev 18:133-46. 2005
    ..Recent studies have confirmed the high accuracy of raised immunoglobulin M levels in the cerebrospinal fluid for the staging of T. b...
  68. ncbi Sex differences in regional gray matter in healthy individuals aged 44-48 years: a voxel-based morphometric study
    Xiaohua Chen
    School of Psychiatry, University of New South Wales, Australia
    Neuroimage 36:691-9. 2007
    ..These differences may provide the structural brain basis for sex differences in certain cognitive functions...
  69. pmc Demonstration of components of antigen 85 complex in cerebrospinal fluid of tuberculous meningitis patients
    Rajpal S Kashyap
    Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88 2 Bajaj Nagar, Nagpur 440010, India
    Clin Diagn Lab Immunol 12:752-8. 2005
    ..their presence remains questionable, and many of these antigens are reported in the blood but not in the cerebrospinal fluid (CSF)...
  70. pmc Quantitative proteomics and metabolomics analysis of normal human cerebrospinal fluid samples
    Marcel P Stoop
    Department of Neurology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Mol Cell Proteomics 9:2063-75. 2010
    The analysis of cerebrospinal fluid (CSF) is used in biomarker discovery studies for various neurodegenerative central nervous system (CNS) disorders...
  71. ncbi Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation
    Masayoshi Ohta
    Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Exp Neurol 187:266-78. 2004
    ..at the level of T8-9, and the BMSCs from the bone marrow of the same strain were infused into the cerebrospinal fluid (CSF) through the 4th ventricle...
  72. ncbi Subarachnoid injection of Microfil reveals connections between cerebrospinal fluid and nasal lymphatics in the non-human primate
    M Johnston
    Neuroscience Program, Department of Laboratory Medicine and Pathobiology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, ON, Canada
    Neuropathol Appl Neurobiol 31:632-40. 2005
    ..and qualitative studies in a variety of mammalian species, it would appear that a significant portion of cerebrospinal fluid (CSF) drainage is associated with transport along cranial and spinal nerves with absorption taking place ..
  73. pmc DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    Zhen Hong
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
    Brain 133:713-26. 2010
    ..In this study, the nature of DJ-1 and alpha-synuclein in human cerebrospinal fluid was studied by a combination of western blotting, gel filtration and mass spectrometry...
  74. pmc The choroid plexus removes beta-amyloid from brain cerebrospinal fluid
    Janelle S Crossgrove
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL 1163D, West Lafayette, IN 47907, USA
    Exp Biol Med (Maywood) 230:771-6. 2005
    beta-Amyloid (Abeta) concentration in the cerebrospinal fluid (CSF) of the brain may be regulated by the choroid plexus, which forms a barrier between blood and brain CSF...
  75. doi Pathogenetic factors for excessive IgA production: Th2-dominated immune response in canine steroid-responsive meningitis-arteritis
    M Schwartz
    Department of Small Animal Medicine and Surgery, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany
    Vet J 187:260-6. 2011
    ..manifestation within the cervical meninges, increased immunoglobulin A (IgA) levels in serum and cerebrospinal fluid (CSF), and a shift of the B:T cell ratio towards a higher percentage of B cells...
  76. doi Administration of cultured autologous bone marrow stromal cells into cerebrospinal fluid in spinal injury patients: a pilot study
    Fukuki Saito
    Emergency and Critical Care Center, Kansai Medical University, Moriguchi, Osaka, Japan
    Restor Neurol Neurosci 30:127-36. 2012
    ..To determine whether intrathecal administration of cultured autologous bone marrow stromal cells (BMSCs) is safe and feasible for treatment of subacute spinal injury...
  77. ncbi Inflammatory cytokine cascade released by leukocytes in cerebrospinal fluid after subarachnoid hemorrhage
    T Takizawa
    Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan
    Neurol Res 23:724-30. 2001
    ..determined the source and time-course of the release of inflammatory cytokines and acute-phase proteins in cerebrospinal fluid (CSF) following SAH...
  78. ncbi Neurocysticercosis: validity of ELISA after storage of whole blood and cerebrospinal fluid on paper
    A Fleury
    , , Limoges, France
    Trop Med Int Health 6:688-93. 2001
    ..We evaluated the suitability of paper for storing blood and cerebrospinal fluid (CSF) until subsequent testing by enzyme-linked immunosorbent assay (ELISA), by testing whole blood samples ..
  79. doi Cerebrospinal fluid and lumbar puncture: a practical review
    Ben L C Wright
    Department of Neurology, University Hospital of North Staffordshire NHS Trust, Stoke on Trent, ST4 7LN, UK
    J Neurol 259:1530-45. 2012
    b>Cerebrospinal fluid is vital for normal brain function. Changes to the composition, flow, or pressure can cause a variety of neurological symptoms and signs...
  80. doi Anatomy and physiology of cerebrospinal fluid
    L Sakka
    Laboratoire d Anatomie, Faculte de Medecine, Universite d Auvergne, 28, Place Henri Dunant, 63001 Clermont Ferrand Cedex 1, France
    Eur Ann Otorhinolaryngol Head Neck Dis 128:309-16. 2011
    The cerebrospinal fluid (CSF) is contained in the brain ventricles and the cranial and spinal subarachnoid spaces. The mean CSF volume is 150 ml, with 25 ml in the ventricles and 125 ml in subarachnoid spaces...
  81. doi Visualization of cerebrospinal fluid movement with spin labeling at MR imaging: preliminary results in normal and pathophysiologic conditions
    Shinya Yamada
    Department of Neurosurgery, Tokai University at Oiso Hospital, Kanagawa, Japan
    Radiology 249:644-52. 2008
    ..This study was HIPAA compliant. The purpose of this study was to visualize the movement of cerebrospinal fluid (CSF) noninvasively by using an unenhanced magnetic resonance imaging technique...
  82. doi ST2859 serogroup A meningococcal meningitis outbreak in Nouna Health District, Burkina Faso: a prospective study
    A Sie
    Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso
    Trop Med Int Health 13:861-8. 2008
    We analysed cerebrospinal fluid samples from suspected meningitis cases in Nouna Health District, Burkina Faso, during the meningitis seasons of 2004-2006...
  83. doi Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers
    Olivier Braissant
    Inborn Errors of Metabolism, Service of Biomedicine, Lausanne University Hospital, Avenue Pierre Decker 2, CI 02 33, CH 1011, Lausanne, Switzerland
    J Inherit Metab Dis 35:655-64. 2012
    ..No uptake of guanidinoacetate from periphery occurs at BBB except under GAMT deficiency, but a net exit of guanidinoacetate seems to occur from CSF to blood at BCSFB, predominantly through the taurine transporter TauT...
  84. ncbi Comparison of findings for patients with Borrelia garinii and Borrelia afzelii isolated from cerebrospinal fluid
    F Strle
    Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Clin Infect Dis 43:704-10. 2006
    ..garinii and B. afzelii isolated from cerebrospinal fluid (CSF) has been reported.
  85. doi The diagnostic value of cytokine and nitric oxide concentrations in cerebrospinal fluid for the differential diagnosis of meningitis
    M Bociaga-Jasik
    Department of Infectious Diseases, Jagiellonian University, Collegium Medicum, Krakow, Poland
    Adv Med Sci 57:142-7. 2012
    ....
  86. pmc Change of the cerebrospinal fluid volume during brain activation investigated by T(1rho)-weighted fMRI
    Tao Jin
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15203, USA
    Neuroimage 51:1378-83. 2010
    A voxel in MRI often contains tissue as well as cerebrospinal fluid (CSF). During functional stimulation, volume fractions of these different water compartments may change...
  87. doi Increase of CD4+TNF{alpha}+IL-2-T cells in cerebrospinal fluid of multiple sclerosis patients
    N Shi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mult Scler 15:120-3. 2009
    ..myristate/ionomycin was flowcytometrically measured in CD4(+) T cells from peripheral blood (PB) and cerebrospinal fluid (CSF) of 29 patients with multiple sclerosis (MS), and 16 with other inflammatory and 41 with other non-..
  88. ncbi Embryonic cerebrospinal fluid regulates neuroepithelial survival, proliferation, and neurogenesis in chick embryos
    Angel Gato
    Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, Valladolid, Spain
    Anat Rec A Discov Mol Cell Evol Biol 284:475-84. 2005
    ..Evidence suggests a physiological role for the cerebrospinal fluid in the development of the brain...
  89. pmc Necessity of meningococcal gamma-glutamyl aminopeptidase for Neisseria meningitidis growth in rat cerebrospinal fluid (CSF) and CSF-like medium
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    J Bacteriol 186:244-7. 2004
    ..GGT)-deficient Neisseria meningitidis strain was much slower than that of the parent strain in rat cerebrospinal fluid (CSF) and in a synthetic CSF-mimicking medium, and the growth failure was suppressed by the addition of ..
  90. pmc Using diffusion MRI for measuring the temperature of cerebrospinal fluid within the lateral ventricles
    L R Kozak
    MR Research Center, Szentagothai J Knowledge Center, Semmelweis University, Budapest, Hungary
    Acta Paediatr 99:237-43. 2010
    ..We aimed to devise a method, based on diffusion-weighted MRI, to measure non-invasively the temperature of the cerebrospinal fluid in the lateral ventricles.
  91. ncbi Transglutaminase activity in serum and cerebrospinal fluid in sporadic amyotrophic lateral sclerosis: a possible use as an indicator of extent of the motor neuron loss
    K Fujita
    Department of Physiology, School of Medicine, Fujita Health University, Aichi, Japan
    J Neurol Sci 158:53-7. 1998
    The activity of transglutaminase (TGase), a marker enzyme for tissue degeneration, was examined in serum and cerebrospinal fluid (CSF) obtained from patients with sporadic amyotrophic lateral sclerosis (SALS), and compared to those from ..
  92. doi Angiogenic potential of the cerebrospinal fluid (CSF) of patients with high-grade gliomas measured with the chick embryo chorioallantoic membrane assay (CAM)
    Mariana Sinning
    Neurology and Neurosurgery Department, Hospital Clinico de la Universidad de Chile, Santiago, Chile
    Biol Res 45:135-8. 2012
    ..Neo-angiogenesis plays a key role in tumor growth and resistance to therapy. A cerebrospinal fluid (CSF) sample could be a useful way to obtain pro-angiogenic predictive or prognostic markers at different ..
  93. ncbi Mammalian embryonic cerebrospinal fluid proteome has greater apolipoprotein and enzyme pattern complexity than the avian proteome
    Carolina Parada
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Catalonia, Spain
    J Proteome Res 4:2420-8. 2005
    ..Understanding these molecules and the mechanisms they control during embryonic neurogenesis may contribute to our understanding of Central Nervous System development and evolution, and these human diseases...
  94. doi Preliminary use of differential scanning calorimetry of cerebrospinal fluid for the diagnosis of glioblastoma multiforme
    Alexis A Chagovetz
    Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA
    J Neurooncol 105:499-506. 2011
    ..We describe the preliminary use of DSC performed on cerebrospinal fluid (CSF) as a diagnostic tool for the identification of patients with glioblastoma multiforme (GBM)...
  95. doi An improved method of transcutaneous cisterna magna puncture for cerebrospinal fluid sampling in rats
    Mahamad Yunnus A Mahat
    Department of DMPK, Pre Formulation and Bioanalytical, Drug Discovery Research, R and D Center, Orchid Chemicals and Pharmaceuticals Limited, Sozhanganallur, Chennai 600119, Tamil Nadu, India
    J Neurosci Methods 211:272-9. 2012
    A simple, reproducible and chronic technique of cerebrospinal fluid (CSF) collection in rats was developed by direct cisterna magna (CM) puncture utilizing stereotaxic apparatus...
  96. doi Technique for collection of cerebrospinal fluid from the cisterna magna in rat
    Christina C Pegg
    Department of Biological Science, ISU, Normal, IL, USA
    J Neurosci Methods 187:8-12. 2010
    b>Cerebrospinal fluid (CSF) is in direct contact with the extracellular space in the central nervous system (CNS), and biological changes in the brain can be reflected in CSF...
  97. pmc Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain
    Fanny Langlet
    Laboratory of Development and Plasticity of the Postnatal Brain, Jean Pierre Aubert Research Centre JPARC, INSERM U837, University of Lille 2, Lille, 59000, France NEUROBESE International Associated Laboratory, 59045, Lille Cedex, France Univ Lille Nord de France, School of Medicine, 59046, Lille Cedex, France
    J Comp Neurol 521:3389-405. 2013
    Tanycytes are highly specialized ependymal cells that form a blood-cerebrospinal fluid (CSF) barrier at the level of the median eminence (ME), a circumventricular organ (CVO) located in the tuberal region of the hypothalamus...
  98. pmc HIV coreceptor tropism in paired plasma, peripheral blood mononuclear cell, and cerebrospinal fluid isolates from antiretroviral-naïve subjects
    S G Parisi
    Department of Histology, Microbiology and Medical Biotechnologies, Padua University, Padua, Italy
    J Clin Microbiol 49:1441-5. 2011
    A survey of HIV coreceptor usage in cerebrospinal fluid (CSF) samples, peripheral blood mononuclear cells (PBMCs), and plasma samples from naïve seropositive patients was conducted. One hundred patients were enrolled in this study...
  99. ncbi Cerebrospinal fluid analysis in the diagnosis and treatment of arterial ischemic stroke
    Emilie M Riou
    Division of Pediatric Neurology, Montreal Children s Hospital McGill University Health Center, Montreal, Quebec, Canada
    Pediatr Neurol 38:1-9. 2008
    ..the advent of magnetic resonance imaging as a rapid and accurate way to diagnose arterial ischemic stroke, cerebrospinal fluid assessment is rarely performed, unless infectious or inflammatory processes are obvious...
  100. pmc Large-scale evaluation of the immuno-mycologics lateral flow and enzyme-linked immunoassays for detection of cryptococcal antigen in serum and cerebrospinal fluid
    Jessica Hansen
    ARUP Laboratories, Salt Lake City, UT, USA
    Clin Vaccine Immunol 20:52-5. 2013
    ..gattii. Detection of cryptococcal capsular antigen (CrAg) in serum and cerebrospinal fluid (CSF) plays an important diagnostic role. We prospectively compared the new Immuno-Mycologics Inc...
  101. doi High concentrations of procoagulant microparticles in the cerebrospinal fluid and peripheral blood of patients with acute basal ganglia hemorrhage are associated with poor outcome
    Man Huang
    Department of Intensive Care Unit, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    Surg Neurol 72:481-9; discussion 489. 2009
    ..The objective of this study was to determine plasma and cerebrospinal fluid (CSF) levels of MPs in patients with spontaneous ICH and to correlate MP levels with Glasgow Coma Scale (..

Research Grants77

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..and seal tissues for controlling the leakage of blood, gastrointestinal fluids, urine, bile, lymph, and cerebrospinal fluid. It is life saving when used on the surfaces of solid visceral organs, such as the liver spleen, pancreas ..
  2. Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidney
    VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2013
    ..and Glu/pSer can be Glu or phospho-Ser) and this motif is phosphorylated in some 75% of human plasma and cerebrospinal fluid phosphoproteins...
  3. Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of
    ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2013
    ..stain, glucose/protein levels, cell count, and bacterial culture (where media/reagents are available) on cerebrospinal fluid (CSF) obtained via lumbar puncture from patients with AFI...
  4. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..we will seek clinical validation by analysis of clinical brain metastasis tissue and malignant cells from cerebrospinal fluid (Aim 2)...
  5. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..psychomotor retardation and fatigue;2) flattening of the diurnal cortisol curve;and 3) increased plasma and cerebrospinal fluid (CSF) concentrations of metabolites of indoleamine 2,3 dioxygenase including kynurenine, quinolinic acid ..
  6. Study of zidovudine addition in HIV-associated neurocognitive disorders
    Albert Anderson; Fiscal Year: 2013
    ..antiretroviral medications differentially affect cognitive improvement in HAND, the role of specific cerebrospinal fluid (CSF) biomarkers as indicators of HAND activity, and the incompletely defined role of monocyte and ..
  7. The Role of the Terminal Complement Pathway in ALS
    Scott R Barnum; Fiscal Year: 2013
    ..in the spinal cord of ALS patients as well as elevated levels of complement activation fragments in cerebrospinal fluid (CSF) or serum...
  8. Diagnostic array for aseptic encephalitis
    Darrell P Chandler; Fiscal Year: 2011
    ..can readily be differentiated from viral causes by biochemistry and gram staining of the cerebrospinal fluid. Importantly, complications arising from CSF infection and appropriate treatment strategies depend on the ..
  9. Complement Activation on Neisseria meningitidis
    Sanjay Ram; Fiscal Year: 2013
    ..Almost all Nm isolates recovered from the blood or cerebrospinal fluid are encapsulated and capsule is important for resistance to C...
  10. Feto-maternal DNA/RNA Trafficking: Biology and Application
    Diana W Bianchi; Fiscal Year: 2013
    ..encompassing evaluation of fetal and placental DNA and mRNA in maternal blood, amniotic fluid, cerebrospinal fluid, and urine...
  11. Copper's Role in Brain LRP-mediated Abeta Efflux and Aging
    Rashid Deane; Fiscal Year: 2010
    ..Mouse endogenous A[unreadable] levels in brain, cerebrospinal fluid (CSF) and plasma will be determined by ELISA...
  12. Organic Cation Transporter PMAT: Physiological Function and Role in Drug Disposit
    Joanne Wang; Fiscal Year: 2013
    ..signaling pathways and in OC transport at barrier tissues including choroid plexus that forms the blood- cerebrospinal fluid (CSF) barrier...
  13. Generating Blood-based Diagnosis for Alzheimer Disease
    Eugenia Wang; Fiscal Year: 2012
    ..for Alzheimer"s disease (AD) requires patients to enduring arduous neuropsychological testing, invasive cerebrospinal fluid tapping, and/or expensive MRI or PET imaging, with definitive diagnosis deferred until brain autopsy...
  14. Role of Neuropeptide Y in Obesity-Receptor Specific Analogs
    Ambikaipakan Balasubramaniam; Fiscal Year: 2013
    ..Patients with anorexia nervosa and bulimia had abnormal levels of NPY in the cerebrospinal fluid, which returned to normal on treatment...
  15. Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Maria Lehtinen; Fiscal Year: 2013
    ..The long-term goal of my research is to elucidate how the cerebrospinal fluid (CSF) functions as a signaling niche that coordinates a rich interaction of signaling factors, acting at ..
  16. Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Maria Lehtinen; Fiscal Year: 2011
    ..The long-term goal of my research is to elucidate how the cerebrospinal fluid (CSF) functions as a signaling niche that coordinates a rich interaction of signaling factors, acting at ..
  17. Vaccine Immunotoxin and Radioimmunotherapy of Primary and Metastatic CNS Tumors
    Darell D Bigner; Fiscal Year: 2013
    ..dissemination of malignant tumor cells within the leptomeningeal space and metastatic spread through the cerebrospinal fluid along the brain and spine. NM from carcinoma of the breast and lung are the most common subtypes...
  18. Clinical and Molecular Biology of Acute and Chronic Traumatic Encephalopathies
    JAMES WAVELL AIKEN; Fiscal Year: 2011
    ..in functional neuroimaging and in the rapid and convenient determination of peptides and proteins in the cerebrospinal fluid and plasma will be reviewed in terms of their possible pathobiological significance as well as their ..
  19. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    David Stump; Fiscal Year: 2013
    ..include: brain edema;intravital visualization and recording of intravascular emboli;BBB leakage into the cerebrospinal fluid;emboli count in the CPB circuit, carotid artery, and jugular vein using the EDAC...
  20. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    William Brown; Fiscal Year: 2009
    ..include: brain edema; intravital visualization and recording of intravascular emboli;BBB leakage into the cerebrospinal fluid; emboli count in the CPB circuit, carotid artery, and jugular vein using the EDAC...
  21. Pathogenesis/Treatment-Inherited Cholesterol Deficiency
    Gordon L Watson; Fiscal Year: 2013
    ..Gene transfer vector will be injected intrathecally into the cerebrospinal fluid of newborn SLOS mice...
  22. Predicting Cognitive Decline in Adults with Down Syndrome
    Ira T Lott; Fiscal Year: 2013
    ..2 key chemical components of Alzheimer plaques and tangles (beta-amyloid and hyperphosporylated tau) in the cerebrospinal fluid. We predict that increased levels of hyperphosporylated tau and lower levels of beta-amyloid in ..
  23. Orexin Receptor Agonists for the Treatment of Excessive Daytime Sleepiness and Ca
    PAUL STUART HUMPHRIES; Fiscal Year: 2013
    ..most patients that suffer from narcolepsy with cataplexy have low or undetectable levels of orexin in their cerebrospinal fluid. EDS associated with narcolepsy has historically been treated with stimulant medications including ..
  24. Role of ABC efflux transporters in ALS
    Davide Trotti; Fiscal Year: 2013
    ..k.a. ABCG2) at the blood brain barrier (BBB) and blood cerebrospinal fluid (BCSF) barrier...
  25. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
    CHRISTOPHER GORDON THANOS; Fiscal Year: 2011
    ..These factors are present in the cerebrospinal fluid of normal adults, as the CP forms the blood- cerebrospinal fluid barrier and is involved in growth factor ..
  26. Inhibition of HIV-Induced Synaptodentritic Damage
    Val S Goodfellow; Fiscal Year: 2013
    ..in this cascade, but a limited subset of mediators has been identified as being up-regulated in the cerebrospinal fluid and postmortem brain tissues of HAND patients: TNF-??, the monocyte chemoattractant MCP-1, and mixed-..
  27. Virus Clearance from the Central Nervous System
    Rodney E Willoughby; Fiscal Year: 2013
    ..b>Cerebrospinal fluid and serum samples from patients who either died of or recovered from CNS rabies infection will be studied ..
  28. Theiler?s virus as a potential cause of Vilyuisk encephalitis
    HOWARD LEE LIPTON; Fiscal Year: 2010
    ..serum titers and serum:CSF ratios of ELISA and neutralizing antibodies to VHEV in VE cases and controls, VE cerebrospinal fluid (CSF) oligoclonal band (OCB) reactivity to VHEV, and whether a 320- bp Cardiovirus amplicon that includes ..
  29. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    Kathleen J Sweadner; Fiscal Year: 2010
    ..and cellular mechanisms of the regulation of the sodium pump (Na,K-ATPase), which is the driving force for cerebrospinal fluid (CSF) secretion...
  30. Iron and Mitochondrial Genomics in Neuro-inflammation and HAND: A CHARTER Study
    Asha R Kallianpur; Fiscal Year: 2013
    ..in CSF, iron transport across the blood-brain barrier as evidenced by levels of iron-related proteins in cerebrospinal fluid (CSF), mtDNA copy number, and genomic DNA methylation patterns, including methylation of inflammation- and ..
  31. The Functional Role of RBM45 in Gene Expression and Neurodegeneration
    Mahlon Collins; Fiscal Year: 2013
    ..We recently performed a cerebrospinal fluid (CSF)-based proteomics study of ALS patients and identified the novel RNA binding protein RBM45 as a ..
  32. Comparative effectiveness of Brain Imaging and Blood Biomarkers in Alzheimer??s d
    Orly Lazarov; Fiscal Year: 2010
    ..are Alzheimer's disease-specific, we will examine alterations in gene expression in neurogenic areas, cerebrospinal fluid and in the plasma of transgenic mice and individuals affected with the disease...
  33. Lyme neuroborreliosis pathogenesis in the rhesus monkey
    MARIO TOMAS PHILIPP; Fiscal Year: 2013
    ..burgdorferi in vitro. A predominant mediator released by microglia in vitro and into the cerebrospinal fluid of rhesus macaques with Lyme meningitis is the chemokine C-C motif ligand 2 (CCL2, aka MCP-1)...
  34. DEVELOPMENT AND REGULATION OF EMOTION IN PRIMATES
    Ned H Kalin; Fiscal Year: 2013
    ..measures of brain structure and function, anxiety-related behaviors, pituitary-adrenal activity, and cerebrospinal fluid (CSF) CRH and NTF3 measures...
  35. Functional genetic evolution of human brain and behavior
    Eric J Vallender; Fiscal Year: 2013
    ..primates ex vivo and in vivo through measurement of mRNA levels and neurochemical concentrations in cerebrospinal fluid and neuroendocrine effects in blood plasma...
  36. Immunomodulatory Roles of Amyloid-Beta and Amyloid Precursor Protein in CNS Autoi
    JACQUELINE LEIGH GRANT; Fiscal Year: 2012
    ..has recently identified an epitope of A[unreadable]42 as a target of adaptive immune responses in the cerebrospinal fluid of relapsing remitting MS (RRMS) patients...
  37. Gestational Stress and Impaired Iron Homeostasis in the Young Infant
    Christopher L Coe; Fiscal Year: 2013
    ..findings in anemic monkeys, neural dysfunction will be indexed by the protein and metabolite profile of cerebrospinal fluid using Western blot and nuclear Magnetic Resonance Spectroscopy techniques...
  38. Improved Source Localization for Pediatric Epilepsy
    Damon Hyde; Fiscal Year: 2013
    ..We will examine improved methods for modeling the skull and cerebrospinal fluid regions of the brain using new MR imaging approaches such as ultrashort echo time (UTE) imaging, and model ..
  39. GE Healthcare Discovery MR750 3T MRI System
    FRANK KOROSEC; Fiscal Year: 2010
    ..rapid imaging, non-Cartesian acquisition trajectories, anatomic vascular imaging, flow imaging of blood and cerebrospinal fluid (CSF), pressure mapping, high temporal resolution imaging of contrast material kinetics, functional brain ..
  40. DORSAL RAPHE NUCLEUS SEROTONIN NEURONS IN ALCOHOLISM
    Mark D Underwood; Fiscal Year: 2012
    ..Serotonin deficiency in alcoholics is hypothesized based on reduced serotonin metabolites in the cerebrospinal fluid, the efficacy of serotonin agonists and uptake inhibitors in reducing alcohol consumption, biochemical ..
  41. Rapid, automated, detection of viral and bacterial pathogens causing meningitis
    Andrew Hemmert; Fiscal Year: 2013
    ..assays from existing panels with five new assays to detect the following ME-causing organisms directly from cerebrospinal fluid (CSF): Enterobacteriaceae, E. coli, Enterococcus species, H. influenza, L...
  42. The Role of HIV-1 Evolution in Neuroadaptation
    TERESA EVERING; Fiscal Year: 2013
    ..The overriding goal of the proposed research is to use HIV-1 variants sequenced from cerebrospinal fluid (CSF), to elucidate HIV-1 CNS evolutionary pathways and explore genetic determinants of neuroadaptation ..
  43. MR SPECTROSCOPY TO REVEAL CNS MECHANISMS OF CYTOKINE-INDUCED BEHAVIORAL CHANGE
    Ebrahim Haroon; Fiscal Year: 2013
    ..including the basal ganglia will be measured by single voxel proton MRS and correlated with blood and cerebrospinal fluid biomarkers of immune activation and kynurenine metabolism...
  44. GFAP as a novel HIV/neuroAIDS biomarker
    Johnny J He; Fiscal Year: 2013
    ..Importantly, we have also obtained preliminary evidence to link the cerebrospinal fluid (CSF) levels to HIV/neuroAIDS pathogenesis...
  45. Mechanisms of Brain Injury after Intraventricular Hemorrhage
    Guohua Xi; Fiscal Year: 2013
    ..from red blood cells reaches its peak concentration by the second day following injection of blood into the cerebrospinal fluid of dogs...
  46. Thoroughfare Channels in CBF Autoregulation at High ICP
    Edwin M Nemoto; Fiscal Year: 2009
    ..We will study CBF autoregulation in two groups of rats of 20 rats each by either increasing ICP by "mock" cerebrospinal fluid (CSF) infusion or lowering arterial blood pressure by phlebotomy...
  47. Crystalline hydroxocobalamin and methemoglobin as a treatment of H2S intoxication
    PHILIPPE A HAOUZI; Fiscal Year: 2013
    ..of these antidotes to lower the concentration of H2S, and its oxidative products, in th blood and the cerebrospinal fluid of adult sheep following infusion of lethal concentrations of H2S...
  48. Transcriptomics in Traumatic Brain Injury: Relationship to Brain Oxygenation and
    Ava M Puccio; Fiscal Year: 2013
    ..work, 'Effect of Short Periods of Normobaric Hyperoxia on Local Brain Tissue Oxygenation &Cerebrospinal Fluid Oxidative Stress Markers in Severe Traumatic Brain Injury', which utilized innovative technology in ..
  49. Identification of altered lipids predictive of anesthetic-induced brain injury
    Xianlin Han; Fiscal Year: 2013
    ..roles in the nervous system, small disturbance in the brain could result in changes of lipids in the brain, cerebrospinal fluid (CSF), and plasma...
  50. Phase II/III Study of Arimoclomol in the Treatment of SOD1 Positive Familial?.
    Merit E Cudkowicz; Fiscal Year: 2013
    ..of patients with sporadic ALS, it crosses the blood-brain barrier and exhibits a dose-dependent increase in cerebrospinal fluid (CSF) concentration...
  51. UNDERSTANDING NEUROBEHAVIORAL DEFICITS IN PRETERM INFANTS THROUGH IMAGING
    David C Van Essen; Fiscal Year: 2012
    ..images, 2) volumetry (volumes for cortical GM, deep nuclear GM, myelinated WM, unmyelinated WM, and cerebrospinal fluid), 3) diffusion tensor imaging (apparent diffusion coefficient, relative anisotropy, axial and radial ..
  52. Neurobiology of Anxiety and Panic Disorders
    Anantha Shekhar; Fiscal Year: 2013
    ..and that patients with panic but not depression symptoms did indeed have high levels of orexin in their cerebrospinal fluid. Little is known about how this disrupted panic regulation leads to many of its debilitating consequences ..
  53. Specificity and Validity of Oxidative Stress Model of Chronic Fatigue Syndrome
    Dikoma C Shungu; Fiscal Year: 2013
    ..deficit of 36% in the most abundant antioxidant in living tissue, glutathione (GSH), increased ventricular cerebrospinal fluid (CSF) lactate, and decreased regional cerebral blood flow (rCBF) compared to controls, which suggested ..
  54. Brain Structure and Function in Adolescents after the Fontan Operation
    MICHAEL JOHN RIVKIN; Fiscal Year: 2012
    ..outcomes will comprise other segmented volumes: cortical and subcortical gray matter, white matter, cerebrospinal fluid (CSF), total intracranial volume (cortical gray matter + subcortical gray matter + white matter + CSF), and ..
  55. Targeting_the_Source_of_Persistent_HIV_Viremia
    Sarah Palmer; Fiscal Year: 2010
    ..suppressive therapy we must compare HIV populations in patient plasma to the HIV populations found in the cerebrospinal fluid (CSF), cells from peripheral blood and cells isolated from other tissues...
  56. Biomarkers of Vasospasm and Outcome following Subarachnoid Hemorrhage
    Sherry Hsiang Yi Chou; Fiscal Year: 2013
    ..In this study, we examine specific molecular biomarkers from blood and cerebrospinal fluid samples collected from SAH subjects in order to understand their potential role in causing vasospasm and ..
  57. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2011
    ..These antibodies are present in serum, cerebrospinal fluid and brain tissue of lupus patients...
  58. Brain injury due to transcranial versus transthoracic blast exposure
    J Marc Simard; Fiscal Year: 2013
    ..is that a blast wave that impacts the cranium tends to injure tissues at density boundaries, especially the cerebrospinal fluid (CSF)-brain density boundaries, predisposing to subarachnoid hemorhage and to injury to periventicular ..
  59. Overcoming Membrane Transporters to Improve CNS Drug Therapy
    Robert S B Clark; Fiscal Year: 2013
    ..for TBI are ATP-binding cassette transporters and solute carriers on the blood-brain (BBB) and blood-cerebrospinal fluid (CSF) barriers which limit bioavailability of drugs to normal and injured brain by active and rapid re-..
  60. Ph 2 Study of Dextromethorphan in the Treatment of Rett Syndrome
    SAKKUBAI R NAIDU; Fiscal Year: 2013
    ..excessive excitatory neuronal activity, and the levels of the excitatory neurotransmitter, glutamate, in cerebrospinal fluid are elevated. Brain magnetic resonance spectroscopy (MRS) also shows high levels of glutamate...
  61. Role of B-cells and CNS antibodies in modulating chronic microglial activation
    James R Lokensgard; Fiscal Year: 2013
    ..provided by applicant): Effective highly active antiretroviral therapy (HAART) reduces HIV RNA levels in cerebrospinal fluid (CSF), as well as in plasma, and has produced profound improvements in health and longevity...
  62. Multimodal Biomarkers in Frontotemporal Lobar Degeneration
    Corey T McMillan; Fiscal Year: 2013
    ..With the support of this K01, I will develop expertise to conduct investigations of cerebrospinal fluid (CSF), genetic, and neuropathological aspects of neurodegenerative diseases...
  63. Improving Outcomes in Hydrocephalus: Bridging the Gap between Basic Science and C
    James McAllister; Fiscal Year: 2009
    ..in Baltimore, MD, two days before the annual meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Research (ISHCSF), which will attract more speakers and attendees and defray expenses for the proposed ..
  64. Actuated Fine-Gauge Spinal Needle Insertion to Reduce Dura Damage and PDPH Risk
    MAUREEN L MULVIHILL; Fiscal Year: 2012
    ..The most common side effect is a debilitating PDPH, caused by leakage of cerebrospinal fluid (CSF) through a residual hole in the dura...
  65. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..Acute psychological stress by immobilization triggered dura mast cell degranulation and resulted in cerebrospinal fluid (CSF) increase of rat mast cell protease (RMCP) I...
  66. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    ..and experimental studies indicates that reduced CBF may be, in part, caused by impaired vascular and cerebrospinal fluid (CSF) compliance and resultant abnormal intracranial pressure (ICP) pulsatility...
  67. RADIOLOGIC ASPECTS OF CEREBROSPINAL FLUID ABSORPTION
    Daniel Gomez; Fiscal Year: 1990
    To produce selective blocks of the Cerebrospinal Fluid (CSF) pathways and study the resulting changes in CSF absorption. A silastic mixture that has given good results in our laboratory will be used to produce the blocks (Ahmadi, et al...
  68. Biomarkers of Oxidative Stress in Parkinson's Disease
    M Flint Beal; Fiscal Year: 2010
    ..A number of laboratories have reported increases in plasma and cerebrospinal fluid biomarkers of oxidative stress in PD...
  69. Implantable Microdevice for the Treatment of Hydrocephalus
    HONGSEOK NOH; Fiscal Year: 2009
    The brain and spinal cord are protected by a fluid called cerebrospinal fluid (CSF)...
  70. BIOSYNTHETIC ACTIVITY OF THE CHOROID PLEXUS
    Joseph Herbert; Fiscal Year: 1993
    The choroid plexus (CP) forms a major interface of the blood- cerebrospinal fluid (CSF) barrier and is responsible for the secretion of a large fraction of the CSF...
  71. REGULATING CEREBROSPINAL FLUID FORMATION
    Barry Hoffer; Fiscal Year: 1992
    ..The goal of this project is to develop further our understanding of the neural control of the production of cerebrospinal fluid (CSF) by the choroid plexus. It is currently known that sympathetic tone inhibits secretion of CSF...
  72. Circadian and Aminergic Regulation of Orexin Neurons
    THOMAS SCAMMELL; Fiscal Year: 2005
    ..individuals often have decreased numbers of orexin neurons and undetectable concentrations of orexin in cerebrospinal fluid, and mice and dogs with mutations in the genes for orexin or its receptors have a phenotype resembling ..
  73. MODULATION OF CHOROID PLEXUS CHOLINE TRANSPORT BY METALS
    Alice Villalobos; Fiscal Year: 2002
    ..an experimental system for predicting physicochemical stress-modulation of choline transport across the cerebrospinal fluid (CSF)-blood barrier, i.e., the choroid plexus epithelium...
  74. MYELIN BASIC PROTEIN PEPTIDES IN BODY FLUIDS
    JOHN WHITAKER; Fiscal Year: 1993
    ..that small peptides of myelin basic protein originating from damaged central nervous system myelin enter cerebrospinal fluid, blood and urine of persons with multiple sclerosis and that measurement of these peptides offers a means ..
  75. DEVELOPMENT OF NOVEL BIOMARKERS FOR ALZHEIMER'S DISEASE
    James Moe; Fiscal Year: 2009
    ..Currently, there are no validated biomarkers identified in patient samples such as cerebrospinal fluid (CSF), blood, and urine that can be used to definitely monitor the progression or regression of AD...
  76. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    ..Choroid epithelial cells secrete cerebrospinal fluid (CSF) as well as peptides that modulate brain development, fluid balance and repair following injury and ..
  77. BIOLOGICAL STUDIES IN SUICIDAL ADOLESCENT INPATIENTS
    Laurence Greenhill; Fiscal Year: 2000
    ..Low levels of the serotonin metabolite 5-HIAA in cerebrospinal fluid (CSF) is a biological marker identifying at-risk adults...