body fluids

Summary

Summary: Liquid components of living organisms.

Top Publications

  1. pmc MicroRNAs in body fluids--the mix of hormones and biomarkers
    Maria Angelica Cortez
    The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Rev Clin Oncol 8:467-77. 2011
  2. ncbi The microRNA spectrum in 12 body fluids
    Jessica A Weber
    Institute for Systems Biology, 1441 North 34th St, Seattle, WA 98103, USA
    Clin Chem 56:1733-41. 2010
  3. pmc Modeling the time evolution of the nanoparticle-protein corona in a body fluid
    Daniele Dell'Orco
    Institute of Biology and Environmental Sciences, Section of Biochemistry, University of Oldenburg, Oldenburg, Germany
    PLoS ONE 5:e10949. 2010
  4. ncbi Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma
    Andre Lopes Carvalho
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0910, USA
    Clin Cancer Res 14:97-107. 2008
  5. ncbi A vaginal fluid simulant
    D H Owen
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Contraception 59:91-5. 1999
  6. ncbi Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids
    Thomas Vaissière
    International Agency for Research on Cancer IARC, Lyon F 69008, France
    Epigenetics 4:221-30. 2009
  7. ncbi Occupational exposure to body fluids among healthcare workers: a report from Iran
    A Hadadi
    Department of Infectious Diseases, Sina Hospital, Hassan Abad Square, Imam Khomini Street, Tehran 11367 46911, Iran
    Singapore Med J 49:492-6. 2008
  8. pmc Human body fluid proteome analysis
    Shen Hu
    School of Dentistry, Division of Oral Biology and Medicine, Dental Research Institute, University of California, Los Angeles, CA 90095, USA
    Proteomics 6:6326-53. 2006
  9. pmc Measurement of GSTP1 promoter methylation in body fluids may complement PSA screening: a meta-analysis
    T Wu
    Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Br J Cancer 105:65-73. 2011
  10. ncbi Quantitative UPLC-MS/MS analysis of underivatised amino acids in body fluids is a reliable tool for the diagnosis and follow-up of patients with inborn errors of metabolism
    W A Huub Waterval
    Laboratory of Biochemical Genetics, Department of Clinical Genetics, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    Clin Chim Acta 407:36-42. 2009

Detail Information

Publications257 found, 100 shown here

  1. pmc MicroRNAs in body fluids--the mix of hormones and biomarkers
    Maria Angelica Cortez
    The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Rev Clin Oncol 8:467-77. 2011
    ..Another avenue of current research is the study of circulating miRNAs in serum, plasma, and other body fluids--miRNAs may act not only within cells, but also at other sites within the body...
  2. ncbi The microRNA spectrum in 12 body fluids
    Jessica A Weber
    Institute for Systems Biology, 1441 North 34th St, Seattle, WA 98103, USA
    Clin Chem 56:1733-41. 2010
    ..Extracellular miRNAs in serum, plasma, saliva, and urine have recently been shown to be associated with various pathological conditions including cancer...
  3. pmc Modeling the time evolution of the nanoparticle-protein corona in a body fluid
    Daniele Dell'Orco
    Institute of Biology and Environmental Sciences, Section of Biochemistry, University of Oldenburg, Oldenburg, Germany
    PLoS ONE 5:e10949. 2010
    ..Eventually equilibrium is reached, at which point the continued exchange will not affect the composition of the corona...
  4. ncbi Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma
    Andre Lopes Carvalho
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0910, USA
    Clin Cancer Res 14:97-107. 2008
    ..To evaluate aberrant promoter hypermethylation of candidate tumor suppressor genes as a means to detect epigenetic alterations specific to solid tumors, including head and neck squamous cell carcinoma (HNSCC)...
  5. ncbi A vaginal fluid simulant
    D H Owen
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Contraception 59:91-5. 1999
    ..Among these properties, pH and osmolarity play a dominant role in physicochemical processes that govern drug release and distribution...
  6. ncbi Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids
    Thomas Vaissière
    International Agency for Research on Cancer IARC, Lyon F 69008, France
    Epigenetics 4:221-30. 2009
    ..However, the reliable detection of DNA methylation changes in body fluids has proven to be technically challenging...
  7. ncbi Occupational exposure to body fluids among healthcare workers: a report from Iran
    A Hadadi
    Department of Infectious Diseases, Sina Hospital, Hassan Abad Square, Imam Khomini Street, Tehran 11367 46911, Iran
    Singapore Med J 49:492-6. 2008
    Healthcare workers (HCWs) are at substantial risk of acquiring blood-borne infections through contact with body fluids of patients...
  8. pmc Human body fluid proteome analysis
    Shen Hu
    School of Dentistry, Division of Oral Biology and Medicine, Dental Research Institute, University of California, Los Angeles, CA 90095, USA
    Proteomics 6:6326-53. 2006
    The focus of this article is to review the recent advances in proteome analysis of human body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar lavage fluid, synovial fluid, nipple aspirate fluid, tear ..
  9. pmc Measurement of GSTP1 promoter methylation in body fluids may complement PSA screening: a meta-analysis
    T Wu
    Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Br J Cancer 105:65-73. 2011
    Prostate-specific antigen (PSA) screening has low specificity. Assessment of methylation status in body fluids may complement PSA screening if the test has high specificity.
  10. ncbi Quantitative UPLC-MS/MS analysis of underivatised amino acids in body fluids is a reliable tool for the diagnosis and follow-up of patients with inborn errors of metabolism
    W A Huub Waterval
    Laboratory of Biochemical Genetics, Department of Clinical Genetics, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    Clin Chim Acta 407:36-42. 2009
    ....
  11. ncbi Micro-RNA - A potential for forensic science?
    Cornelius Courts
    Institute of Forensic Medicine, University of Bonn, Bonn, Germany
    Forensic Sci Int 203:106-11. 2010
    ..We conclude that analysis of miRNA and perhaps small non-coding RNAs in general clearly has potential for forensic applications and merits attention of forensic scientists...
  12. ncbi RNA in forensic science
    M Bauer
    Institute of Legal Medicine, University of Bonn, Bonn, Germany
    Forensic Sci Int Genet 1:69-74. 2007
    ..The molecular identification of body fluids by analysis of cell-specific mRNA expression already represents a new technique supplementing DNA analysis in ..
  13. ncbi Porous poly(alpha-hydroxyacid)/Bioglass composite scaffolds for bone tissue engineering. I: Preparation and in vitro characterisation
    V Maquet
    Centre for Education and Research on Macromolecules, University of Liege, Belgium
    Biomaterials 25:4185-94. 2004
    ..Formation of hydroxyapatite on the surface of composites, as an indication of their bioactivity, was recorded by EDXA, X-ray diffractometry and confirmed by Raman spectroscopy...
  14. pmc Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs
    Nam Soo Joo
    Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California 94305 2130, USA
    J Clin Invest 120:3161-6. 2010
    ..These data are a step toward determining whether gland secretory defects contribute to CF airway disease...
  15. ncbi Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice
    E Hummler
    Institut de Pharmacologie et de Toxicologie de l Université, Lausanne, Switzerland
    Nat Genet 12:325-8. 1996
    ..Alpha-ENaC(-/-) neonates developed respiratory distress and died within 40 h of birth from failure to clear their lungs of liquid. This study shows that ENaC plays a critical role in the adaptation of the newborn lung to air breathing...
  16. pmc Expression of homing receptors on IgA1 and IgA2 plasmablasts in blood reflects differential distribution of IgA1 and IgA2 in various body fluids
    Sari H Pakkanen
    Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Clin Vaccine Immunol 17:393-401. 2010
    ..produced Ig isotype, the mechanisms underlying the differential distribution of IgA subclasses in various body fluids remain unclear...
  17. pmc Prediction of body fluids where proteins are secreted into based on protein interaction network
    Le Le Hu
    Institute of Systems Biology, Shanghai University, Shanghai, China
    PLoS ONE 6:e22989. 2011
    Determining the body fluids where secreted proteins can be secreted into is important for protein function annotation and disease biomarker discovery...
  18. ncbi Body fluid volumes measurements by impedance: A review of bioimpedance spectroscopy (BIS) and bioimpedance analysis (BIA) methods
    Michel Y Jaffrin
    Department of Biological Engineering, Technological University of Compiegne, 60205 Compiegne Cedex, France
    Med Eng Phys 30:1257-69. 2008
    ..Kushner et al. method gave values of TBW not significantly different from those of Jaffrin et al. and DXA, as Hannan's method in men, but Lukaski and Deurenberg methods led to an underestimation...
  19. ncbi Body fluid volume determination via body composition spectroscopy in health and disease
    Ulrich M Moissl
    Fresenius Medical Care Deutschland GmbH, Research and Development, Daimlerstrasse 15, D 61352 Bad Homburg, Germany
    Physiol Meas 27:921-33. 2006
    ..2 L (48%) for 24 subjects with extreme BMIs (<20 and >30). BCS may be an appropriate method for body fluid volume determination over a wide range of body compositions in different states of health and disease...
  20. pmc Importance of whole-body bioimpedance spectroscopy for the management of fluid balance
    Peter Wabel
    Fresenius Medical Care, Bad Homburg, Germany
    Blood Purif 27:75-80. 2009
    ..Preventing the deleterious effects of fluid overload and dehydration is difficult to achieve. Objective and clinically applicable methods for the determination of a target representing normohydration are needed...
  21. ncbi Quantitative detection of DNA methylation states in minute amounts of DNA from body fluids
    Anupam Paliwal
    Epigenetics Group, International Agency for Research on Cancer IARC, 150 cours Albert Thomas, 69008 Lyon, France
    Methods 52:242-7. 2010
    ..Thus, this method should facilitate DNA methylation studies aiming to discover epigenetic biomarkers, and should prove particularly valuable in profiling a large sample series of body fluids from molecular epidemiology studies.
  22. ncbi Electrochemical study of Type 304 and 316L stainless steels in simulated body fluids and cell cultures
    Yee Chin Tang
    Division of Materials and Manufacturing Science, Graduate School of Engineering, 2 1 Yamada oka, Suita, Osaka University, Osaka 565 0871, Japan
    Acta Biomater 2:709-15. 2006
    ..On the other hand, both Type 304 and 316L stainless steels became more susceptible to pitting corrosion when they were covered with cells...
  23. ncbi Effects of bilateral nephrectomy and angiotensin II replacement on body fluids in foetal sheep
    K J Gibson
    School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia
    Clin Exp Pharmacol Physiol 26:765-73. 1999
    1. To determine the importance of the kidneys in maintaining the normal volume and composition of foetal body fluids, measurements were made in 11 chronically catheterized foetuses (123-136 days) that had been bilaterally nephrectomized ..
  24. ncbi Biomimetic apatite formation on chemically treated titanium
    Lenka Jonásová
    Department of Materials Science III, University of Erlangen Nuremberg, Martensstrasse 5, Erlangen 91058, Germany
    Biomaterials 25:1187-94. 2004
    ..The treatment of titanium by acid etching in HCl and subsequently in NaOH is a suitable method for providing the metal implant with bone-bonding ability...
  25. ncbi Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats
    H G Folkesson
    Department of Animal Physiology, Lund University, S 223 62 Lund, Sweden
    J Appl Physiol (1985) 88:416-24. 2000
    ..These observations may have clinical relevance because glucocorticoid therapy is commonly used with acute lung injury...
  26. ncbi Composition of corrosion layers on a magnesium rare-earth alloy in simulated body fluids
    Ralf Rettig
    Department of Materials Science, Institute for Corrosion and Surface Science, University of Erlangen Nuremberg, Erlangen, Germany
    J Biomed Mater Res A 88:359-69. 2009
    ....
  27. ncbi microRNA biomarkers in body fluids of prostate cancer patients
    Ruprecht Kuner
    Unit Cancer Genome Research, Division of Molecular Genetics, German Cancer Research Center and National Center of Tumor Diseases, Heidelberg, Germany
    Methods 59:132-7. 2013
    ..miRNAs - small non-coding RNAs involved in posttranscriptional regulation of gene expression - in tissues and body fluids of cancer patients hold great promise to identify specific biomarkers, which may be useful for early diagnosis ..
  28. pmc Challenges for biomarker discovery in body fluids using SELDI-TOF-MS
    Muriel De Bock
    Laboratory of Clinical Chemistry, GIGA Research, University of Liege, CHU, B36, 4000 Liege 1, Belgium
    J Biomed Biotechnol 2010:906082. 2010
    ..Finally, some new insights for biomarker identification and validation challenges are provided...
  29. ncbi Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy
    Y Wang
    Cardiovascular Research Institute and Departments of Medicine, Anesthesia, and Physiology, University of California, San Francisco 94143 0130, USA
    J Appl Physiol (1985) 87:1852-60. 1999
    ....
  30. ncbi Mitochondrial DNA control region diversity in hairs and body fluids of monozygotic triplets
    Heidi Pfeiffer
    Institute of Legal Medicine, University of Munster, Röntgenstrasse 23, 48149 Muenster, Germany
    Int J Legal Med 118:71-4. 2004
    ..From these results it can be assumed that besides a common genetic bottleneck during embryonic development, a post-embryonic bottleneck seems to exist in each hair follicle...
  31. ncbi Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues
    Heli Nygren
    VTT Technical Research Centre of Finland, Espoo, Finland
    Methods Mol Biol 708:247-57. 2011
    ..The repeatability of the analysis proved to be good, with relative standard errors for spiked samples being between 4.51 and 10.44%. The throughput of the methodology described here is over 100 samples a day...
  32. pmc cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways
    Robert J Lee
    Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6085, USA
    J Clin Invest 120:3137-48. 2010
    ..These results identify important molecular mechanisms of cAMP-dependent secretion, including a requirement for Ca2+ signaling, and suggest new therapeutic approaches to correct defective submucosal gland secretion in CF...
  33. ncbi Fetal nucleic acids in maternal body fluids: an update
    Diana W Bianchi
    Tufts New England Medical Center, Box 394, 750 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1075:63-73. 2006
    ..On the other hand, we are cautious and concerned about the accuracy of "at-home" kits for fetal gender detection...
  34. ncbi Medical student exposure to blood and infectious body fluids
    S Koenig
    University of Washington School of Medicine, Seattle 98195, USA
    Am J Infect Control 23:40-3. 1995
    Few data assess the exposure of students to blood or other potentially infectious body fluids during medical school...
  35. ncbi Mechanisms of pulmonary edema clearance
    Gokhan M Mutlu
    Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Physiol Lung Cell Mol Physiol 289:L685-95. 2005
    ..Better understanding of the mechanisms that regulate edema clearance may lead to therapeutic interventions to improve the ability of lungs to clear fluid, which is of clinical significance...
  36. ncbi Quantification of human beta-defensin-2 and -3 in body fluids: application for studies of innate immunity
    Santosh K Ghosh
    Department of Biological Sciences, Case School of Dental Medicine, Cleveland, OH 44106 4905, USA
    Clin Chem 53:757-65. 2007
    Human beta-defensins (hBDs) are epithelial cell-derived antimicrobial and immunoregulatory cationic peptides. Our objective was to establish an analytical tool to quantify inducible hBD-2 and -3 in body fluids.
  37. ncbi Synthesis of biomimetic Ca-hydroxyapatite powders at 37 degrees C in synthetic body fluids
    A C Tas
    Department of Metallurgical and Materials Engineering, Middle East Technical University, Ankara, Turkey
    Biomaterials 21:1429-38. 2000
    ....
  38. ncbi Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1
    Thomas Weimbs
    Dept of Molecular, Cellular, and Developmental Biology and Neuroscience Research Institute, Univ of California, Santa Barbara, CA 93106 9610, USA
    Am J Physiol Renal Physiol 293:F1423-32. 2007
    ..The existence of many known cellular and molecular similarities between renal repair and ADPKD supports this model...
  39. ncbi Isolated microvesicles from peripheral blood and body fluids as observed by scanning electron microscope
    Anita Mrvar-Brecko
    Laboratory of Clinical Biophysics, Faculty of Medicine, University of Ljubljana, Slovenia University Medical Center Ljubljana, Slovenia
    Blood Cells Mol Dis 44:307-12. 2010
    ..Since all cells shed microvesicles, it can be expected that they will be found in different body fluids. The potential diagnostic value of microvesicles has been suggested, however, a standardized protocol for ..
  40. ncbi Cystic fibrosis
    Steven M Rowe
    Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    N Engl J Med 352:1992-2001. 2005
  41. ncbi Occupational exposures to blood in a dental teaching environment: results of a ten-year surveillance study
    F S Younai
    Section of Oral Biology and Medicine, University of California, Los Angeles School of Dentistry, 90095 1668, USA
    J Dent Educ 65:436-48. 2001
    ..The observed rates of occupational exposures to blood and body fluids in this report are consistent with published reports from several other educational settings...
  42. pmc Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice
    Y Song
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Physiol 525:771-9. 2000
    ....
  43. ncbi mRNA profiling in forensic genetics I: Possibilities and limitations
    Marielle Vennemann
    Institute of Legal Medicine, University of Freiburg, Albertstr 9, 79104 Freiburg, Germany
    Forensic Sci Int 203:71-5. 2010
    ..This review aims to give a brief overview of the possible advantages of postmortem mRNA profiling and to shed further light into the limitations of this method arising from reduced RNA integrities...
  44. pmc Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease
    Richard R Drake
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Proteomics 72:907-17. 2009
    ..Continued characterization of the prostate specific protein components of EPS urine combined with optimization of clinical collection procedures should facilitate discovery of new biomarkers for prostate cancer...
  45. ncbi Peptide mapping of proteins in human body fluids using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
    Jonas Bergquist
    Department of Analytical Chemistry, Institute of Chemistry, Uppsala University, P O Box 531, SE 751 21 Uppsala, Sweden
    Mass Spectrom Rev 21:2-15. 2002
    Human body fluids have been rediscovered in the post-genomic era as great sources of biological markers and perhaps particularly as sources of potential protein biomarkers of disease...
  46. ncbi Survival and biofilm formation of Listeria monocytogenes in simulated vaginal fluid: influence of pH and strain origin
    Sandra F Borges
    CBQF Escola Superior de Biotecnologia, Universidade Catolica Portuguesa, Porto, Portugal
    FEMS Immunol Med Microbiol 62:315-20. 2011
    ..No significant differences in biofilm production were detected between food and clinical isolates. As L. monocytogenes are biofilm producers, this increases the probability of occurrence of neonatal infection...
  47. ncbi Occupational exposure to blood and body fluids among a group of Turkish nursing and midwifery students during clinical practise training: frequency of needlestick and sharps injuries
    Mevlüde Karadağ
    Tokat School for Health Sciences, Gaziosmanpasa University, Tokat, Turkey
    Jpn J Nurs Sci 7:129-35. 2010
    ..To ascertain the number of needlestick and sharps injuries (NSSIs) in nursing and midwifery students and to assess the use of universal precautions among injured and non-injured students...
  48. ncbi The hydration ability of three commercially available sports drinks and water
    Rebecca J Hill
    Department of Paediatrics and Child Health, University of Queensland, Queensland, Australia
    J Sci Med Sport 11:116-23. 2008
    ....
  49. pmc Use of the BacT/Alert blood culture system for culture of sterile body fluids other than blood
    P Bourbeau
    Geisinger Medical Center, Danville, Pennsylvania, USA
    J Clin Microbiol 36:3273-7. 1998
    Studies have demonstrated that large-volume culture methods for sterile body fluids other than blood increase recovery compared to traditional plated-medium methods...
  50. pmc Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects
    M R Knowles
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, University of North Carolina at Chapel Hill 27599, USA
    J Clin Invest 100:2588-95. 1997
    ....
  51. ncbi Accumulation of 2H2O in plasma and eccrine sweat during exercise-heat stress
    Lawrence E Armstrong
    Human Performance Laboratory, University of Connecticut, Storrs, CT 06269 1110, USA
    Eur J Appl Physiol 108:477-82. 2010
    The purpose of this research was to characterize the movement of ingested water through body fluids, during exercise-heat stress...
  52. ncbi High resolution proteome/peptidome analysis of body fluids by capillary electrophoresis coupled with MS
    Eric Schiffer
    Mosaiques Diagnostics and Therapeutics AG, Hanover, Germany
    Proteomics 6:5615-27. 2006
    All organisms contain thousands of proteins and peptides in their body fluids. A deeper insight into the functional relevance of these polypeptides under different physiological and pathophysiological conditions and the discovery of ..
  53. ncbi Evaluation of the Bactec microbial detection system for culturing miscellaneous sterile body fluids
    Fusun Zeynep Akcam
    Department of Clinical Microbiology and Infectious Diseases, Medical School of Suleyman Demirel University, Isparta, Turkey
    Res Microbiol 157:433-6. 2006
    This study sought to evaluate the efficacy of the Bactec blood culture system for culturing sterile body fluids, in comparison with traditional culture methods...
  54. ncbi Implications of postvaccination hepatitis B surface antigenemia in the management of exposures to body fluids
    Ana Martin-Ancel
    Pediatrics and Neonatology Unit, Fundacion Hospital Alcorcon, Madrid, Spain
    Infect Control Hosp Epidemiol 25:611-3. 2004
    ..Evaluation of the infectious status of HBV should rely on other means if vaccination has recently occurred...
  55. ncbi Knowledge and occupational exposure to blood and body fluids among health care workers and medical students
    Ljiljana Marković Denić
    Instituite of Epidemiology, Faculty of Medicine, University of Belgrade
    Acta Chir Iugosl 59:71-5. 2012
    Health workers and medical students are at occupational risk of blood-borne diseases during the accidents, that is, via percutaneous injury or entry of blood or body fluids through the mucosa or injured skin.
  56. ncbi Capillary electrophoretic analyses of drugs in body fluids: sample pretreatment and methods for direct injection of biofluids
    D K Lloyd
    Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Chromatogr A 735:29-42. 1996
    ..Finally, direct-injection microanalyses are mentioned...
  57. ncbi Pentosidine in osteoarthritis: HPLC determination in body fluids and in tissues
    Pavel Spacek
    Institute of Rheumatology, Na Slupi 4, 128 50 Prague, Czech Republic
    Rheumatol Int 26:923-7. 2006
    ..0002 and P<0.01) from healthy subjects (40.2+/-16.5 nmol/mmol creat.). In the newly formed granulation tissue, PEN concentrations are significantly lower than in cartilage and in synovial tissues...
  58. ncbi Immunochemical assay for deoxyribonuclease activity in body fluids
    Anna Cherepanova
    Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, 8, Lavrentiev Ave, Novosibirsk, 630090, Russia
    J Immunol Methods 325:96-103. 2007
    ..36+/-0.20 U/ml. DNase II-like activity was not detected in the plasma samples. The data obtained confirm that DNase I-like enzymes are responsible for the majority of deoxyribonuclease activity in blood plasma...
  59. ncbi A fatal case of chlorate poisoning: confirmation by ion chromatography of body fluids
    H Eysseric
    Fédération de Toxicologie Clinique et Biologique, CHU de Grenoble, France
    J Forensic Sci 45:474-7. 2000
    ..Specific ion chromatography was used afterhand to assay the chlorate in various body fluids. The technique was based on a separation on an ion exchange Dionex AS 12A column coupled with conductivity ..
  60. ncbi Collection of biological samples in forensic toxicology
    R J Dinis-Oliveira
    Institute of Legal Medicine, Faculty of Medicine, University of Porto, Porto, Portugal
    Toxicol Mech Methods 20:363-414. 2010
    ..This comprehensive review article is intented as a significant help for forensic toxicologists to accomplish their frequently overwhelming mission...
  61. ncbi [Occupational exposure to blood and body fluids in a Department of Odontostomatologic Sciences: results of a ten-year surveillance study]
    Maria Rosaria Gatto
    Dipartimento di Scienze Odontostomatologiche Alma Mater Studiorum Università di Bologna
    Med Lav 101:218-27. 2010
    ..Evaluation of occupational exposures can assist with practice modifications, redesign of equipment, and targeted educational efforts...
  62. ncbi Measurement of prostate-specific antigen and human glandular kallikrein 2 in different body fluids
    J Lovgren
    Department of Laboratory Medicine, Lund University, University Hospital, Malmo, Sweden
    J Androl 20:348-55. 1999
    It has been demonstrated that prostate-specific antigen (PSA), in spite of its name, can be detected in body fluids and tumors from a variety of organs...
  63. ncbi Distribution of acid sphingomyelinase in human various body fluids
    I Takahashi
    Department of Pediatrics, University School of Medicine, Akita, Japan
    Tohoku J Exp Med 192:61-6. 2000
    Enzyme activities of acid sphingomyelinase (ASM) were determined in various human cell-free body fluids, serum, cerebrospinal fluid, urine, salivary fluid, tear fluid, and synovial fluid, using assay buffers with or without Zn2+ -cation...
  64. ncbi Occupational blood and body fluids exposures in health care workers: four-year surveillance from the Northern France network
    Amaud Tarantola
    CCLIN Paris Nord, Institut Biomedical des Cordeliers, 15 21 Rue de l Ecole de Médecine, 75006 Paris, France
    Am J Infect Control 31:357-63. 2003
    ..These findings are similar to those in other countries and reflect the overall improvement in the management of occupational risk of BBF in health care workers...
  65. ncbi Disk diffusion bioassays for the detection of antibiotic activity in body fluids: applications for the Pneumonia Etiology Research for Child Health project
    Amanda J Driscoll
    International Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 855 N Wolfe St, Suite 600, Baltimore, MD 21205, USA
    Clin Infect Dis 54:S159-64. 2012
    ..Although there are limitations to the disk diffusion method, its low cost, ease of use, and ability to broadly detect antibiotic pretreatment make it an appealing method for epidemiologic studies such as PERCH...
  66. ncbi The interpretation of trace element analysis in body fluids
    T L Guidotti
    Department of Environmental and Occupational Health, School of Public Health and Health Services, George Washington University, Washington, DC 20052, USA
    Indian J Med Res 128:524-32. 2008
    ..interpretation of trace element analysis has lagged behind the technology available to measure the elements in body fluids. Reports can be difficult to interpret and requires knowledge of toxicokinetics, the dynamics of how the trace ..
  67. ncbi Exposure measurement of aflatoxins and aflatoxin metabolites in human body fluids. A short review
    Yin Hui Leong
    Doping Control Centre, Universiti Sains Malaysia, Penang, Malaysia
    Mycotoxin Res 28:79-87. 2012
    ..This paper focuses on exposure measurement of aflatoxins and aflatoxin metabolites in various human body fluids. Research on different metabolites present in blood, urine, breast milk, and other human fluids or tissues ..
  68. pmc 2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting
    Freek G Bouwman
    Department of Human Biology, NUTRIM, Maastricht University, Maastricht, The Netherlands
    BMC Med Genomics 4:24. 2011
    ..Proteomic technologies applied for profiling human biofluids and blood cells are considered to reveal new biomarkers of exposure or provide insights into novel mechanisms of adaptation...
  69. ncbi Frequency of hepatitis B immunity and occupational exposures to body fluids among Brazilian medical students at a public university
    Luiz Carlos Marques de Oliveira
    Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Uberlandia, Uberlandia, MG, Brasil
    Rev Inst Med Trop Sao Paulo 52:247-52. 2010
    ..0%, being similar among men (47.8%) and women (43.2%). Of all these accidents, 57.7% were due to body fluids coming in contact with mucosa and 42.3% due to cut and puncture accidents...
  70. pmc Insights into fetal and neonatal development through analysis of cell-free RNA in body fluids
    Diana W Bianchi
    Mother Infant Research Institute at Tufts Medical Center, Department of Pediatrics, Floating Hospital for Children at Tufts Medical Center, Boston, MA 02111, USA
    Early Hum Dev 86:747-52. 2010
    ..current and future clinical applications of analyzing cell-free fetal DNA and RNA in both maternal and neonatal body fluids, including maternal plasma, serum, whole blood, amniotic fluid, and neonatal saliva...
  71. ncbi Detection of DNA methylation changes in body fluids
    Triantafillos Liloglou
    University of Liverpool Cancer Research Centre, Liverpool, United Kingdom
    Adv Genet 71:177-207. 2010
    ..DNA methylation changes have been detected in a variety of human body fluids associated with a large number of malignant and benign diseases...
  72. ncbi Formation of disinfection by-products in indoor swimming pool water: the contribution from filling water natural organic matter and swimmer body fluids
    Amer Kanan
    Department of Environmental Engineering and Earth Sciences, Clemson University, Anderson, SC 29625, USA
    Water Res 45:926-32. 2011
    ..Experiments with filling waters collected from WTP effluents at three different times showed more variability in HAA than THM formation at the WTPs studied...
  73. ncbi Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats
    J F Pittet
    Departments of Anesthesia, Medicine, and Surgery, and Cardiovascular Research Institute, University of California San Francisco, CA 94110, USA
    J Immunol 166:6301-10. 2001
    ....
  74. ncbi Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections
    T Ihi
    Third Department of Internal Medicine, Miyazaki Medical College, Japan
    Clin Infect Dis 25:1134-40. 1997
    ..Our results suggest that HNPs have physiological significance in infection and that this family of peptides may be useful in assessing neutrophil function during infection...
  75. ncbi Occupational blood and body fluid exposure of university health care workers
    Elisabetta Davanzo
    Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy
    Am J Infect Control 36:753-6. 2008
    ..Occupational exposure to bloodborne pathogens caused by percutaneous injuries or mucosal contamination is common in hospital settings...
  76. ncbi Nitrogen metabolites and related enzymatic activities in the body fluids and tissues of the hydrothermal vent tubeworm Riftia pachyptila
    M De Cian
    Equipe Ecophysiologie, Observatoire Océanologique de Roscoff UPMC, CNRS, INSU, Station Biologique, BP 74, F 29682 Roscoff Cedex, France
    J Exp Biol 203:2907-20. 2000
    ..Although no definitive conclusions could be drawn regarding the nitrogen regime of Riftia pachyptila, this in vitro study gives several indications for future research in this area...
  77. ncbi Novel chemiluminescence-inducing cocktails, part II: measurement of the anti-oxidant capacity of vitamins, thiols, body fluids, alcoholic beverages and edible oils
    Isaac Ginsburg
    Institute of Dental Research, Hadassah Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem Campus, Jerusalem, Israel
    Inflammopharmacology 12:305-20. 2004
    ..those generated by activated phagocytes, can rapidly assess the total anti-oxidant capacities (TAOC) in body fluids derived from patients suffering of excessive oxidative stress...
  78. pmc Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells
    James P Garnett
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 286:41069-82. 2011
    ....
  79. ncbi Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays
    Petra Krumpochova
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    FASEB J 26:738-47. 2012
    ..Transportomics has broad applicability, as it is not restricted to urine and can be applied to other ATP-dependent transport proteins as well...
  80. ncbi High TGF-beta2 levels during primary retinal detachment may protect against proliferative vitreoretinopathy
    Suzanne C Dieudonné
    Eye Research Institute Maastricht, Department of Ophthalmology, University Hospital Maastricht, Maastricht, The Netherlands
    Invest Ophthalmol Vis Sci 45:4113-8. 2004
    ..The exact role of these factors in the early events, immediately after primary retinal detachment, is not yet known, and determining their roles was therefore the purpose of this study...
  81. pmc Sys-BodyFluid: a systematical database for human body fluid proteome research
    Su Jun Li
    Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Nucleic Acids Res 37:D907-12. 2009
    Recently, body fluids have widely become an important target for proteomic research and proteomic study has produced more and more body fluid related protein data. A database is needed to collect and analyze these proteome data...
  82. ncbi Hydroxyapatite crystals biologically inspired on titanium by using an organic template based on the copolymer of acrylic acid and itaconic acid
    Chao Zhang
    Key Laboratory of Oral Biomedical Engineering, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, People s Republic of China
    J Biomed Mater Res A 92:63-9. 2010
    ..The copolymer of acrylic acid and itaconic acid overlayer which is rich of carboxylate groups can lead to the deposition of needle-like and homogeneous HA on the surface after immersion in SBF...
  83. ncbi Analysis of body fluids for forensic purposes: from laboratory testing to non-destructive rapid confirmatory identification at a crime scene
    Kelly Virkler
    Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, United States
    Forensic Sci Int 188:1-17. 2009
    ..In addition, the biospectroscopy methods are universally applicable to all body fluids unlike the majority of current techniques which are valid for individual fluids only...
  84. ncbi Establishment of a novel specific ELISA system for rat N- and C-ERC/mesothelin. Rat ERC/mesothelin in the body fluids of mice bearing mesothelioma
    Yoshiaki Hagiwara
    Immuno Biological Laboratories, 5 1 Aramachi, Takasaki shi, Gunma 370 0831, Japan
    Cancer Sci 99:666-70. 2008
    ..rat N-ERC/mesothelin but also C-ERC/mesothelin, and the first data on the presence of rat ERC/mesothelin in the body fluids of rat malignant mesothelioma-bearing nude mice...
  85. ncbi The ADVIA 2120 hematology system: flow cytometry-based analysis of blood and body fluids in the routine hematology laboratory
    Neil Harris
    University of Florida Shands Hospital Core Laboratory, Gainesville, Florida, USA
    Lab Hematol 11:47-61. 2005
    ..Finally, we discuss research applications and future directions, such as the use of this hematology analyzer in the determination of fetal lung maturity...
  86. ncbi Comparative proteomic analysis of mammalian animal tissues and body fluids: bovine proteome database
    Chiara D'Ambrosio
    Proteomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, Via Argine 1085, 80147 Naples, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 815:157-68. 2005
    ..Mammalian cells from different tissues/body fluids express different thousands of proteins with a predicted dynamic range of up to five to six orders of magnitude,..
  87. ncbi The role of calcium gluconate in electrochemical activation of titanium for biomimetic coating of calcium phosphate
    S M A Shibli
    Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram, Kerala 695 581, India
    J Biomed Mater Res A 87:994-1002. 2008
    ..5 times higher concentration of Ca. Biomimetic growth was also improved by the addition of calcium gluconate in the SBF solution...
  88. ncbi Prenatal diagnosis using cell-free nucleic acids in maternal body fluids: a decade of progress
    Jill L Maron
    Department of Pesiatrics, Tufts New England Center, Boston, MA 02111, USA
    Am J Med Genet C Semin Med Genet 145:5-17. 2007
    ..Prenatal diagnosis is poised to evolve from detection of aneuploidy to detection of deviation from normal development, which should provide novel opportunities for fetal treatment...
  89. ncbi Effect of carbonate content and buffer type on calcium phosphate formation in SBF solutions
    S Jalota
    School of Materials Science and Engineering, Clemson University, Clemson, SC 29634, USA
    J Mater Sci Mater Med 17:697-707. 2006
  90. ncbi Detection of Amyloid-beta aggregates in body fluids: a suitable method for early diagnosis of Alzheimer's disease?
    S A Funke
    Forschungszentrum Julich, ISB 3, 52425 Julich, Germany
    Curr Alzheimer Res 6:285-9. 2009
    ..During the past years, body fluids of AD patients were assayed for their content of total or soluble Abeta(1-40) or Abeta(1-42) concentrations ..
  91. ncbi Chemokine levels in subretinal fluid obtained during scleral buckling surgery after rhegmatogenous retinal detachment
    Lukas J A G Ricker
    Eye Research Institute Maastricht, Department of Ophthalmology, University Hospital Maastricht, Maastricht, The Netherlands
    Invest Ophthalmol Vis Sci 51:4143-50. 2010
    ..The exact role of these chemokines, their correlation with IL-6 after primary RRD, and their association with the future development of PVR are not yet known...
  92. ncbi Detection of hepatitis C virus (HCV) in body fluids from HCV monoinfected and HCV/HIV coinfected patients
    Adrián Farías
    Instituto de Virologia Dr J M Vanella, Facultad de Ciencias Medicas Universidad Nacional de Cordoba, Cordoba, Argentina
    Hepatogastroenterology 57:300-4. 2010
    ..C Virus (HCV) transmission is supported by the demonstration that the actual virus is present in several body fluids. In this study, we investigated the relationship between the detection of HCV RNA in body fluids (saliva, ..
  93. pmc Guided optimization of fluid status in haemodialysis patients
    Petr Machek
    Fresenius Medical Care Ds, Prague, Czech Republic
    Nephrol Dial Transplant 25:538-44. 2010
    ..Objective and clinically applicable methods for the determination of the normohydration status on an individual basis are needed to help in the identification of an appropriate target weight...
  94. ncbi Infection risks following accidental exposure to blood or body fluids in health care workers: a review of pathogens transmitted in published cases
    Arnaud Tarantola
    International and Tropical Department, National Institute for Public Health Surveillance, InVS, Saint Maurice, France
    Am J Infect Control 34:367-75. 2006
    ..cleaning personnel are exposed to the risk of occupational infection following accidental exposure to blood or body fluids (BBF) contaminated with a virus, a bacteria, a parasite, or a yeast...
  95. ncbi HIV in body fluids during primary HIV infection: implications for pathogenesis, treatment and public health
    C D Pilcher
    School of Medicine, University of North Carolina at Chapel Hill, 27599-7030, USA
    AIDS 15:837-45. 2001
    OBJECTIVE: To describe initial viral dissemination to peripheral tissues and infectious body fluids during human primary HIV infection. DESIGN: Observational cohort study...
  96. pmc Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli
    Michel Azizi
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, and INSERM, CIC 9201, Paris, France
    J Am Soc Nephrol 19:1015-24. 2008
  97. ncbi Proteomic analysis to identify breast cancer biomarkers in nipple aspirate fluid
    Hannah Alexander
    Division of Biological Sciences, and Department of Surgery, University of Missouri, Columbia, Missouri 65212, USA
    Clin Cancer Res 10:7500-10. 2004
    ....
  98. ncbi A comparative proteinomic analysis of nipple aspiration fluid from healthy women and women with breast cancer
    J L Noble
    Department of Academic Surgery Breast Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK
    Eur J Cancer 43:2315-20. 2007
    ..05). These data suggest that invasive breast cancer may result in a field change across both breasts and that proteomic profiling of NAF may have more value in breast cancer risk assessment than as a diagnostic or screening tool...
  99. ncbi Noninvasive oxygen partial pressure measurement of human body fluids in vivo using magnetic resonance imaging
    Greg Zaharchuk
    University of California, San Francisco, 505 Parnassus Avenue, San Francisco, California 94143 0628, USA
    Acad Radiol 13:1016-24. 2006
    The oxygen partial pressure (pO2) of human body fluids reflects the oxygenation status of surrounding tissues. All existing fluid pO2 measurements are invasive, requiring either microelectrode/optode placement or fluid removal...
  100. ncbi The development of an 18-locus Y-STR system for forensic casework
    Ashley Hall
    Graduate Program in Biomolecular Science, University of Central Florida, PO Box 162366, Orlando, Florida 32816 2366, USA
    Anal Bioanal Chem 376:1234-46. 2003
    ..Specifically, stringent performance checks on their efficacy need to be carried out using casework-type specimens in order to determine potential confounding effects from female DNA...
  101. pmc IL-1beta, IL-6 and IL-8 levels in gyneco-obstetric infections
    Beatriz Basso
    Laboratorio de Microbiologia, Cátedra de Clínica Pediatrica Universidad Nacional de Córdoba, Argentina
    Infect Dis Obstet Gynecol 13:207-11. 2005
    ..One hundred and fifty-one patients were studied during the second or third trimester of their pregnancy...

Research Grants73

  1. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..75 x 0.75 x 9 mm) that is hermetically sealed against body fluids to enable long-term in vivo operation...
  2. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer L Coburn; Fiscal Year: 2010
    ..peridomestic rats, results in a continuous reservoir for human infection through exposure to animal tissue or body fluids containing Leptospira, or to urine-contaminated water sources...
  3. Feto-maternal DNA/RNA Trafficking: Biology and Application
    Diana W Bianchi; Fiscal Year: 2013
    ..normal and abnormal fetal gene expression can be distinguished from each other using cell-free mRNA in maternal body fluids such as whole blood and amniotic fluid...
  4. Clinical trial of self complementary AAV8-mediated gene transfer for hemophilia B
    Andrew M Davidoff; Fiscal Year: 2013
    ..responses to the hFIX transgene product and AAV capsid proteins and 3) to access viral shedding into various body fluids. Recruitment will be limited to adults (greater than or equal to 18 years of age) with a confirmed diagnosis of ..
  5. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    Thomas R Kozel; Fiscal Year: 2013
    ..of which of the potentially hundreds or thousands of fungal antigens produced in vivo will show up in body fluids in concentrations sufficient for detection...
  6. Plasma RNA based Early Lung Cancer Detection by Tethered Cationic Lipoplex Assay
    SERGE P NANA-SINKAM; Fiscal Year: 2013
    ..Since miRNAs are more stable than other nucleic acids such as mRNA in blood or other body fluids because they could be protected by bounding to endogeneous RNase proteins or contained within cell secreted ..
  7. Mucosal innate immune defense to Rift Valley fever virus
    Amy G Hise; Fiscal Year: 2010
    ..to humans can occur either by mosquito bite, food contamination or aerosol inhalation during exposure to body fluids of RVFV-infected livestock...
  8. CellTrap: A novel solid phase platform for analysis of stem/progenitor cells
    NICANOR I contact MOLDOVAN; Fiscal Year: 2010
    ..Rapid detection of rare cells in blood and other body fluids is critical for the diagnosis of a variety of age-dependent pathological conditions, and for screening ..
  9. A Proteomic Approach to Biomarker Discovery in Prion Disease
    Lingjun Li; Fiscal Year: 2009
    ..in combination with a suite of bioinformatics tools to identify a panel of biomarkers of prion disease in body fluids collected from live animals infected with prion disease during the preclinical incubation period...
  10. Copper Uptake from Plasma Ceruloplasmin
    Maria C Linder; Fiscal Year: 2012
    ..by applicant): Ceruloplasmin (Cp) is the main Cu-containing protein in the blood plasma and some other body fluids. A GPI- linked form is tethered to the surface of some cells...
  11. Innate Immune Sensing of Rift Valley Fever Virus
    Amy G Hise; Fiscal Year: 2010
    ..transmission to humans occurs either by insect bite or aerosol inhalation, which occurs during exposure to body fluids of RVFV-infected animals...
  12. Definition of Serum Ribonucleoprotein Composition and its Regulation and Function
    Thomas Tuschl; Fiscal Year: 2013
    ..However, the presence of host exRNA in serum and other body fluids challenges the current models of RNA based immune recognition...
  13. Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer
    Joanna Phillips; Fiscal Year: 2013
    ..in the extracellular environment and have great potential as novel biomarkers for early detection of cancer in body fluids. This innovative project assembles a diverse team of investigators to integrate mechanistic studies of SULF ..
  14. Salivary Biomarkers in the Diagnosis of BRONJ
    Tara L Aghaloo; Fiscal Year: 2013
    ..In the era of biomarkers, utilizing serum or salivary body fluids is an attractive approach to aid in diagnosis, monitoring, and evaluating responses to treatment...
  15. Prostate Cancer Detection by Molecular Urinalysis
    Christian P Pavlovich; Fiscal Year: 2010
    ..b>Body fluids such as urine may contain molecular information regarding the presence of prostate cancer...
  16. Serum microRNA as biomarker for radiation injury to lung and hematopoietic cells
    Dipanjan Chowdhury; Fiscal Year: 2013
    ..20-22 nts), extremely stable molecules that are easily recovered and detected in a variety of tissues and body fluids including blood serum...
  17. Cell-Binding Adhesins of Leptospira interrogans
    Jenifer L Coburn; Fiscal Year: 2013
    ..peridomestic rats, results in a continuous reservoir for human infection through exposure to animal tissue or body fluids containing Leptospira, or to urine-contaminated water sources...
  18. Fibronectin Binding MSCRAMMs
    AXEL MAGNUS HOOK; Fiscal Year: 2013
    Fibronectin (Fn) is an abundant 450kDa mammalian glycoprotein found in a soluble form in body fluids and deposited as a fibrillar, insoluble form in the Extracellular Matrix (ECM) of most tissues...
  19. Multiplexed Protein &miRNA Biomarker-based Next-gen Test for Alzheimers Disease
    ARMIN H REITMAIR; Fiscal Year: 2013
    ..on the same platform, ultrasensitive detection of both proteins and nucleic acids (including miRNAs) in body fluids. NTI recently achieved extension from 2-color (2c) to 4-color (4c) ALEX, substantially expanding its ..
  20. Molecular Markers for the Diagnosis of Pancreatic Cancer
    Surinder K Batra; Fiscal Year: 2012
    ..that will require multidisciplinary approaches, including imaging studies, tissue sampling, and analysis of body fluids from patients. There is no specific tumor marker available for diagnosing pancreatic cancer...
  21. NATIONAL NEUROLOGICAL AIDS BANK
    Elyse J Singer; Fiscal Year: 2012
    ..Volunteers agree to donate medical information and samples of their body fluids during their lives, and their tissues and organs after their deaths...
  22. Multimodal MRI markers of nigrostriatal pathology in Parkinson's disease
    Xuemei Huang; Fiscal Year: 2013
    ..By melding in vivo high-resolution DTI and R2* MRI data with assessment of Fe-related protein profiles in body fluids, we expect to gain marked insight into predicting PD progression...
  23. Safe, Rapid Telomere Extension to Prevent and Treat Hypertension
    Helen M Blau; Fiscal Year: 2013
    ..In 2007 it was discovered that in the human body, exosomes transport mRNA between cells via body fluids including blood, and in 2011 autologous exosomes were used to deliver nucleic acid via i.v. injection...
  24. Live Smart Live Safe: HIV Prevention for Youth with Intellectual Disabilities
    JENNIFER J WELLS; Fiscal Year: 2013
    ..relationship development b) practices associated with abstinence, and c) transmission of HIV through high-risk body fluids. This project is consistent with the mission of the National Institute of Mental Health Division of AIDS ..
  25. ALEX for fast ultrasensitive multiplexed detection &quantification of microRNAs
    ARMIN H REITMAIR; Fiscal Year: 2013
    ..Identified expression patterns in body fluids and biopsies underscore their potential as biomarkers...
  26. PCR-free Multiplexed Detection of Circulating miRNA in Blood
    Tza Huei Wang; Fiscal Year: 2013
    ..miRNA microarrays are woefully lacking in the requisite sensitivity to detect these circulating miRNA panels in body fluids. In this project, we propose to develop a single molecule length coding platform to address the unmet clinical ..
  27. BK Virus: Its role in BLL Causation
    JENNIFER Y WEBSTER-CYRIAQUE; Fiscal Year: 2013
    ..determinants of replication, anti-BKV antibody status, and viral gene expression will be analyzed in gland, and body fluids (saliva, sera, urine, plasma, PBL for study of viral compartmentalization)...
  28. Proteomic Profiles and Novel Biomarkers in Juvenile Rheumatoid Arthritis
    Margalit E Rosenkranz; Fiscal Year: 2010
    ..of proteomics, or protein pattern analysis, is the characterization and quantitation of proteins in tissues and body fluids. Disease proteomics has emerged as a rapidly advancing discipline for delineating altered protein expression, ..
  29. Migratory Properties of HIV-infected T Cells in Vivo
    THORSTEN ROMAN MEMPEL; Fiscal Year: 2013
    ..While extracellular virions are abundant in body fluids of infected individuals, it is currently not known whether free virus contributes to transmission between ..
  30. Quick-Set Material-Phase II
    CAROLYN MARGARET PRIMUS; Fiscal Year: 2013
    ..The Quick-Set material was shown to have an alkaline pH, release calcium ions, form hydroxyapatite in synthetic body fluids, and meet ADA 57 requirements as they apply...
  31. Multiplexed Detection of Cell Free DNA Biomarkers for Cancer
    Tza Huei Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Circulating cell-free DNA have been found to freely exist in human body fluids such as blood, urine, and stool...
  32. Pathogenetic Mechanisms of Prion Disease
    Pierluigi Gambetti; Fiscal Year: 2013
    ..and Tissue Cores are proposed that will provide well characterized animals, animal and human tissues, and body fluids. The Program Project takes advantage of the diverse but complementary expertise of three senior investigators ..
  33. Post-translational Modifications of Proteins in Parkinson?s disease
    Jing Zhang; Fiscal Year: 2012
    ..technique to characterize a sub- proteome with a unique PTM (glycosylation) that is highly enriched in body fluids, i.e. proteins carrying great potentials to be biomarkers for PD-D...
  34. Substrate Specificity of the Choroid Plexus and Kidney Transporter Oat1
    Sanjay K Nigam; Fiscal Year: 2013
    ..for regulating the distribution of drugs, toxins and metabolites between the CSF, blood, urine and other body fluids. In this RESUBMISSION application, we propose to employ in silico, in vitro, structural biological and in vivo ..
  35. Oral Biomarkers for HPV-related Head and Neck Cancer
    SARA ISABEL PAI; Fiscal Year: 2013
    ..Methylation-specific PCR (MSP) is an established method to detect methylated genes in tissue and body fluids. The detection of methylated HPV genes in the ORS via MSP may be a novel screening tool that we propose to ..
  36. AAV Gene Therapy for AAT deficiency
    Richard J Samulski; Fiscal Year: 2013
    ..mutant PiZZ protein in the endoplasmic reticulum of liver cells rather than normal secretion into the blood and body fluids. From our previous two year R01 application funded from the ARRA (R01DK084033), we have generated a substantial ..
  37. Genomic and Proteomic Biomarkers of Biological Responses to Exposure
    CORAL LAMARTINIERE; Fiscal Year: 2010
    ..tissue, the experimented data will give us unbiased information on the target tissue and the peripheral tissue/body fluids that will be important to bioinformatically correlate with the human data...
  38. Novel Surfaces for Enriching Epithelial Cells: A Breastmilk Model
    Maria M Santore; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Harvesting and concentrating epithelial cells from body fluids is a challenging (expensive and time-consuming) but important task required for translational advances in the early-detection and ..
  39. Impact of HCMV proteins on viral replication and cellular signaling pathways
    SCOTT SLETTEN TERHUNE; Fiscal Year: 2013
    ..Infection occurs through exchange of body fluids and the initiation of a lytic replication cycle within the host...
  40. Non-invasive Biomarker Panels for Early Detection of Lung Squamous Cell Carcinoma
    Feng Jiang; Fiscal Year: 2013
    ..The study will strongly support one of the PA's main interests "Combination of ncRNA and genetic variation markers in body fluids to increase accuracy of cancer diagnosis".
  41. Home-Based Lithium Level Testing for Bipolar Patients
    KUMAR SUBRAMANIAN; Fiscal Year: 2009
    ..The concentration of lithium in serum, plasma, urine, or other body fluids have been determined by flame emission photometry, atomic absorption spectroscopy or electrochemically using ..
  42. PMCA Detection of CWD Infection in Cervid and Non-Cervid Species
    EDWARD ARTHUR HOOVER; Fiscal Year: 2013
    ..shed high levels of infectious prions in saliva, blood, urine, and feces, and in the tissues generating those body fluids and excreta, thereby leading to facile transmission by direct contact and environmental contamination...
  43. Nanoparticle scavengers for in vivo sequestration of overdosed drug molecules
    Zhiguo Zhou; Fiscal Year: 2013
    ..to develop core-shell therapeutic nanoparticles that are capable of extracting lipophilic molecules from body fluids to its lipophili core, and thus overdosed drug is sequestered and its effective concentration is lowered...
  44. Development and Validation of Point-of-Care Tests for Tuberculosis
    Jane M Schuh; Fiscal Year: 2012
    ..to concurrently identify a panel of Mycobacterium tuberculosis target antigens that have been identified in body fluids during active infection. It is anticipated that a paired test to detect M...
  45. NON-INVASIVE SALIVA-BASED DIABETES AUTOANTIBODY SCREENING.
    Srinivasa R Nagalla; Fiscal Year: 2013
    ..The extension of accurate autoantibody detection to alternative body fluids can facilitate the accessibility of this importan diagnostic parameter to at-risk patient groups for more cost-..
  46. Quantitative and Qualitative Differential Expression Proteomics
    MARTIN ARTHUR MOSELEY; Fiscal Year: 2010
    ..protein expression analyses of biologic materials such as cell and tissue lysates, blood, and other body fluids. The research projects enabled by this proposal aim to advance our understanding of disease areas including ..
  47. Mesothelin as biomarker and therapeutic target
    INGEGERD E HELLSTROM; Fiscal Year: 2011
    ..Several years ago we constructed an ELISA to detect mesothelin in body fluids and showed that it may aid in the diagnosis of tumors which express this molecule, including OvC, to satisfy a ..
  48. Nanotrap technology for one step preservation and amplification of cancer biomark
    LANCE ALLEN LIOTTA; Fiscal Year: 2013
    ..core-shell hydrogel nanoparticles containing high affinity reactive chemical baits that harvests biomarkers in body fluids. Our nanoparticles can be pre loaded into Vacutainer(R) blood collection tubes, or other body fluid collection ..
  49. In Vivo Regulated Release and Function of Extracellular Small RNAs
    Robert H Blelloch; Fiscal Year: 2013
    ..to active signaling, and which can be differentiated based on the selectivity and form of their release into body fluids. The Center proposes to tackle this hypothesis by integrating the efforts of six principle investigators with ..
  50. A Microfluidic Protein Separation Device Based on Dielectrophoresis
    Alexandra Ros; Fiscal Year: 2012
    ..challenging due to the transient nature of the involved peptide species and their extremely low abundance in body fluids. This exploratory proposal aims to develop dielectrophoretic devices for the efficient, rapid and gel-free ..
  51. A Microfluidic Protein Separation Device Based on Dielectrophoresis
    Alexandra Ros; Fiscal Year: 2011
    ..challenging due to the transient nature of the involved peptide species and their extremely low abundance in body fluids. This exploratory proposal aims to develop dielectrophoretic devices for the efficient, rapid and gel-free ..
  52. Direct analysis of perchlorate and iodide in human tissues by isotachophoresis-zo
    Vladislav Dolnik; Fiscal Year: 2012
    ..and validate a fast, sensitive, and reproducible method for direct analysis of perchlorate and iodide in human body fluids by isotachophoresis-zone electrophoresis on chip...
  53. DEGENERATIVE AND DEMENTING DISEASES OF AGING
    Stanley B Prusiner; Fiscal Year: 2013
    ..Tg mice make it practical to measure the titers of prions throughout brain as well as in peripheral organs and body fluids collected from dead sCJD patients. We also propose to develop guinea pig models of sCJD and variant (v) CJD...
  54. The Role of Exosomes in Semen for HIV Infection in the Genital Mucosa of Women
    Florian Hladik; Fiscal Year: 2012
    ..Semen has the highest concentration of exosomes among all body fluids studied, but relatively little is known about the biology of these particles...
  55. Micro-Spectroscopy for Cytological Screening, and Staging of Disease
    Max Diem; Fiscal Year: 2010
    ..In classical cytology, visual inspection is used to detect changes in the morphology of cells obtained from body fluids, or by exfoliation or thin needle biopsy, while in classical pathology stained tissue sections are examined ..
  56. Modular Assembly Approach to Engineer Prevascularized Large 3D Tissue Constructs
    Wei Shen; Fiscal Year: 2012
    ..networks that undergo anastomosis with the host vasculature after implantation and allow interstitial flow of body fluids. Successful accomplishment of this project will address the problem of insufficient mass transfer that hampers ..
  57. Virus Electrodes for Fungal Pathogen Detection
    Gary Fujii; Fiscal Year: 2009
    ..technology for rapid detection of infectious disease specific protein markers in biologically relevant body fluids. For this purpose, Aspergillus fumigatus, a fungus that causes disease in patients with immunocompromised ..
  58. Mitochondrial dynamics and metabolomic biomarkers in neurodegenerative disorders
    Eugenia Trushina; Fiscal Year: 2013
    ..metabolomic pro- files and global changes in energetic and metabolic signaling circuits in neurons, tissue and body fluids from transgenic animal models and human patients that are associated with Mito dysfunction caused by genetic ..
  59. Osteoclast Exosomes
    AGNES VIGNERY; Fiscal Year: 2013
    ..In addition, since exosomes are present in body fluids and are used as biomarkers to detect diseases such as cancer, we also hypothesize that exosomes released by ..
  60. Epigenetic Biomarker Discovery in HPV related HNSCC
    Joseph A Califano; Fiscal Year: 2013
    ..However, epigenetic alterations have been detected in body fluids from premalignant and early stage cancers and multiplex tests have shown promise for identification of patients ..
  61. Single molecule microarrays for the detection of mutant DNA in body fluids
    ALFREDO ANDRES CELEDON; Fiscal Year: 2013
    ..Detecting these mutations in body fluids can be used for cancer management and early cancer detection...
  62. THROMBOPOIETIN: IMMUNOASSAY AND CHARACTERIZATION
    TED MC DONALD; Fiscal Year: 1993
    ..murine metakaryocytopoiesis, 9) establish cell-lines from tumors that produce TSF, 10) continue TSF testing in body fluids of patients with platelet production disorders, and 11) begin new studies on genetic transfer of TSF...
  63. TRYPANOSOME VARIANT SURFACE GLYCOPROTEIN CARBOHYDRATES
    Herman van Halbeek; Fiscal Year: 1993
    ..The parasite evades the mammalian host's immunological response to its presence in body fluids by antigenic variation: the expression of a sequence of immunologically distinct glycoprotein coats over the ..
  64. PGA antigenemia for early diagnosis of anthrax
    Thomas Kozel; Fiscal Year: 2009
    ..Detection of microbial antigens in body fluids is a proven technology in diagnosis of infectious disease...
  65. CEREBROVASCULAR AMYLOIDOSIS
    Peter Gorevic; Fiscal Year: 1999
    ..P-component, proteoglycans, and certain apolipoproteins, several of which also circulate in blood and other body fluids, some of which may be important in explaining amyloid deposition in specific organs or anatomic sites in tissue,..
  66. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer Coburn; Fiscal Year: 2009
    ..and livestock results in a continuous reservoir for human infection through exposure to animal tissue or body fluids containing Leptospira, or to urine-contaminated water sources...
  67. MOLECULAR DISSECTION OF CONGENITAL NEPHROGENIC DI
    ROBERT WILDIN; Fiscal Year: 2000
    ..As a result, they quickly become dehydrated and their body fluids hyperosmolar when water intake is restricted...
  68. Direct Peritoneal Resuscitation from Hypovolemic Shock
    Richard Garrison; Fiscal Year: 2007
    ..consists of disruption of the cellular metabolic functions endothelial barrier properties, redistribution of body fluids and electrolytes, a systemic inflammatory response, and a deleterious intestinal vasoconstriction and a ..
  69. MYELIN BASIC PROTEIN PEPTIDES IN BODY FLUIDS
    JOHN WHITAKER; Fiscal Year: 1993
    ..immunosorbent assay (ELISA) using monoclonal antibody to quantitate myelin basic protein-like material in body fluids; this technical aim is to improve consistency and feasibility of the immunoassay...
  70. Profiling Urine Glycosylation of PSA and other Glyco-Biomarkers in Prostate Cance
    Lewis Pannell; Fiscal Year: 2009
    ..reports have shown that changes occur in the glycosylation of PSA in cancer but were measured in different body fluids (serum for PC and seminal fluid for healthy), and effectively in only one patient...
  71. X RAY STRUCTURAL STUDIES OF LACTOFERRIN
    Edward Baker; Fiscal Year: 2000
    ..transferrin, part of the team of proteins that regulates the levels of iron, and possibly other metals, in the body fluids of animals...
  72. URINALYSIS FOR PATIENT COMPLIANCE TO CAM THERAPY
    Rama Ramanujam; Fiscal Year: 2006
    ..a rapid, real-time assay to determine the effectiveness of constituents of biologically active CAM agents in body fluids. The assay is based on an in vitro bioluminescence imaging system...
  73. Wireless Multichannel Electrocorticogram Recording for Epilepsy Monitoring
    Stuart Cogan; Fiscal Year: 2009
    ..The stability of the arrays in body fluids is obtained through the use of amorphous SiC (a-SiC) and silicone encapsulation, made possible through advances ..