sweat

Summary

Summary: The fluid excreted by the SWEAT GLANDS. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products.

Top Publications

  1. pmc Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report
    Philip M Farrell
    Department of Pediatrics and Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Pediatr 153:S4-S14. 2008
  2. ncbi Blood, urine, and sweat (BUS) study: monitoring and elimination of bioaccumulated toxic elements
    Stephen J Genuis
    University of Alberta, Edmonton, AB, Canada
    Arch Environ Contam Toxicol 61:344-57. 2011
  3. pmc Sweat testing to evaluate autonomic function
    Ben M W Illigens
    Autonomic and Peripheral Nerve Laboratory, Dept of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Clin Auton Res 19:79-87. 2009
  4. ncbi Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin
    Masamoto Murakami
    Division of Dermatology, University of California San Diego, and VA San Diego Healthcare Center, 92161, USA
    J Invest Dermatol 119:1090-5. 2002
  5. ncbi Smelling a single component of male sweat alters levels of cortisol in women
    Claire Wyart
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA
    J Neurosci 27:1261-5. 2007
  6. pmc Pregame urine specific gravity and fluid intake by National Basketball Association players during competition
    Kristin L Osterberg
    Gatorade Sports Science Institute, 617 West Main Street, Barrington, IL 60010, USA
    J Athl Train 44:53-7. 2009
  7. ncbi Evidence that androstadienone, a putative human chemosignal, modulates women's attributions of men's attractiveness
    Tamsin K Saxton
    School of Biological Sciences, University of Liverpool, Liverpool, L69 7ZB, UK
    Horm Behav 54:597-601. 2008
  8. ncbi Nanoduct sweat testing for rapid diagnosis in newborns, infants and children with cystic fibrosis
    Marie Claire Desax
    Department of Pediatrics, University of Berne, Berne, Switzerland
    Eur J Pediatr 167:299-304. 2008
  9. ncbi Sweat mineral-element responses during 7 h of exercise-heat stress
    Scott J Montain
    Military Nutrition Div, US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Int J Sport Nutr Exerc Metab 17:574-82. 2007
  10. ncbi Sweat rate, salt loss, and fluid intake during an intense on-ice practice in elite Canadian male junior hockey players
    Matthew S Palmer
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Appl Physiol Nutr Metab 33:263-71. 2008

Detail Information

Publications279 found, 100 shown here

  1. pmc Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report
    Philip M Farrell
    Department of Pediatrics and Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Pediatr 153:S4-S14. 2008
    ..The diagnosis of CF is not always straightforward, however. The sweat chloride test remains the gold standard for CF diagnosis but does not always give a clear answer...
  2. ncbi Blood, urine, and sweat (BUS) study: monitoring and elimination of bioaccumulated toxic elements
    Stephen J Genuis
    University of Alberta, Edmonton, AB, Canada
    Arch Environ Contam Toxicol 61:344-57. 2011
    ..study was designed to assess the concentration of various toxic elements in three body fluids: blood, urine and sweat. Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with ..
  3. pmc Sweat testing to evaluate autonomic function
    Ben M W Illigens
    Autonomic and Peripheral Nerve Laboratory, Dept of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Clin Auton Res 19:79-87. 2009
    ..Clinical assessments of sudomotor function include thermoregulatory sweat testing (TST), quantitative sudomotor axon reflex testing (QSART), silicone impressions, the sympathetic skin ..
  4. ncbi Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin
    Masamoto Murakami
    Division of Dermatology, University of California San Diego, and VA San Diego Healthcare Center, 92161, USA
    J Invest Dermatol 119:1090-5. 2002
    The eccrine gland is one of the major cutaneous appendages and secretes sweat. Its principal function is thermoregulation during exposure to a hot environment or physical exercise...
  5. ncbi Smelling a single component of male sweat alters levels of cortisol in women
    Claire Wyart
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA
    J Neurosci 27:1261-5. 2007
    Rodents use chemosignals to alter endocrine balance in conspecifics. Although responses to human sweat suggest a similar mechanism in humans, no particular component of human sweat capable of altering endocrine balance in conspecifics ..
  6. pmc Pregame urine specific gravity and fluid intake by National Basketball Association players during competition
    Kristin L Osterberg
    Gatorade Sports Science Institute, 617 West Main Street, Barrington, IL 60010, USA
    J Athl Train 44:53-7. 2009
    ..020). Whether initial hydration status based on a urine measure is related to subsequent drinking response during exercise or athletic competition is unclear...
  7. ncbi Evidence that androstadienone, a putative human chemosignal, modulates women's attributions of men's attractiveness
    Tamsin K Saxton
    School of Biological Sciences, University of Liverpool, Liverpool, L69 7ZB, UK
    Horm Behav 54:597-601. 2008
    ..The results suggest that androstadienone can influence women's attraction to men, and also that research into the modulatory effects of androstadienone should be made within ecologically valid contexts...
  8. ncbi Nanoduct sweat testing for rapid diagnosis in newborns, infants and children with cystic fibrosis
    Marie Claire Desax
    Department of Pediatrics, University of Berne, Berne, Switzerland
    Eur J Pediatr 167:299-304. 2008
    Determination of chloride concentration in sweat is the current diagnostic gold standard for Cystic Fibrosis (CF)...
  9. ncbi Sweat mineral-element responses during 7 h of exercise-heat stress
    Scott J Montain
    Military Nutrition Div, US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Int J Sport Nutr Exerc Metab 17:574-82. 2007
    Uncertainty exists regarding the effect of sustained sweating on sweat mineral-element composition.
  10. ncbi Sweat rate, salt loss, and fluid intake during an intense on-ice practice in elite Canadian male junior hockey players
    Matthew S Palmer
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Appl Physiol Nutr Metab 33:263-71. 2008
    ..This study examined the pre-practice hydration, on-ice fluid intake, and sweat and sodium losses of 44 candidates for Canada's junior men's hockey team (mean +/- SE age, 18.4 +/- 0...
  11. ncbi Measurement of nasal potential difference in young children with an equivocal sweat test following newborn screening for cystic fibrosis
    Isabelle Sermet-Gaudelus
    CRCM and INSERM U845, Hopital Necker, Faculte de Medecine Necker, Universite Rene Descartes, Paris, France
    Thorax 65:539-44. 2010
    ..problem arising from cystic fibrosis (CF) newborn screening is the significant number of infants with hypertrypsinaemia (HIRT) with sweat chloride levels in the intermediate range and only one or no identified CF-causing mutations.
  12. pmc Determination of silver nanoparticle release from antibacterial fabrics into artificial sweat
    Kornphimol Kulthong
    National Nanotechnology Center, National Science and Technology Development Agency, 111 Thailand Science Park, Phahonyothin Road, Pathumthani, 12120, Thailand
    Part Fibre Toxicol 7:8. 2010
    ..claimed nanosilver and laboratory-prepared silver coated fabrics into various formulations of artificial sweat, each made according to AATCC, ISO and EN standards...
  13. ncbi Bilateral sweat tests with two different methods as a part of cystic fibrosis newborn screening (CF NBS) protocol and additional quality control
    Dorota Sands
    Paediatric Department Centre CF, Institute of Mother and Child, Warsaw, Poland
    Folia Histochem Cytobiol 48:358-65. 2010
    ..Those, in whom the sweat test is elevated, undergo further medical procedures...
  14. pmc Elevated neuroimmune biomarkers in sweat patches and plasma of premenopausal women with major depressive disorder in remission: the POWER study
    Giovanni Cizza
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20852, USA
    Biol Psychiatry 64:907-11. 2008
    ..We used a skin sweat patch, recently validated in healthy control subjects, and recycling immunoaffinity chromatography to measure ..
  15. ncbi Fear-related chemosignals modulate recognition of fear in ambiguous facial expressions
    Wen Zhou
    Department of Psychology MS 25, Rice University, Houston, TX 77005, USA
    Psychol Sci 20:177-83. 2009
    ..In two experiments, the chemosignal of fearful sweat biased women toward interpreting ambiguous expressions as more fearful, but had no effect when the facial emotion ..
  16. ncbi Startle response potentiation to chemosensory anxiety signals in socially anxious individuals
    Bettina M Pause
    Department of Experimental Psychology, University of Duesseldorf, Duesseldorf, FRG
    Int J Psychophysiol 74:88-92. 2009
    ..Axillary sweat was collected from students, awaiting an oral examination at the university (anxiety condition) and from the same ..
  17. ncbi Guidelines for the performance of the sweat test for the diagnosis of cystic fibrosis
    Anne Green
    Department of Clinical Chemistry, Birmingham Children s Hospital, Steelhouse Lane, Birmingham B4 6NH, UK
    Ann Clin Biochem 44:25-34. 2007
    ..and supported by the Cystic Fibrosis Trust) has developed evidence-based guidelines for the performance of the sweat test in the UK...
  18. ncbi Defective sweating responses in atopic dermatitis
    Tetsuo Shiohara
    Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
    Curr Probl Dermatol 41:68-79. 2011
    While sweat is thought to be one of the important factors provoking exacerbations of clinical symptoms in atopic dermatitis (AD), little attention has been drawn to a beneficial role of sweat in the development of AD lesions...
  19. ncbi Impaired sweating function in adult atopic dermatitis: results of the quantitative sudomotor axon reflex test
    K Eishi
    Department of Dermatology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Japan
    Br J Dermatol 147:683-8. 2002
    ..Impaired sweating is thought to be a cause of barrier dysfunction in atopic dermatitis (AD)...
  20. ncbi Diagnosis of cystic fibrosis by sweat testing: age-specific reference intervals
    Avantika Mishra
    Department of Biochemical Genetics, VCGS Pathology, The Royal Children s Hospital, Parkville, Victoria, Australia
    J Pediatr 153:758-63. 2008
    To develop reference intervals (RIs) for sweat chloride and sodium in healthy children, adolescents, and adults.
  21. ncbi [Cholinergic urticaria successfully treated by immunotherapy with partially purified sweat antigen]
    Toshihiko Tanaka
    Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University
    Arerugi 56:54-7. 2007
    ..Similar eruptions were induced by sauna-bathing, and skin test with autologous sweat showed a flare and wheal reaction...
  22. ncbi Diagnosing cystic fibrosis--asthma and failure to thrive as indications for a sweat test
    Dan Bar-Zohar
    Pediatric Gastroenterology Unit, Dana Children s Hospital, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv, 64239, Israel
    J Med 35:93-103. 2004
    ..with asthma or failure to thrive (FTT) are frequently referred for the quantitative pilocarpine iontophoresis sweat test (QPIT) for diagnosing cystic fibrosis (CF)...
  23. pmc Detecting cocaine use through sweat testing: multilevel modeling of sweat patch length-of-wear data
    Hilary James Liberty
    National Development and Research Institutes, Inc NDRI, 71 West 23rd Street, New York, New York 10010, USA
    J Anal Toxicol 28:667-73. 2004
    Although urine analysis remains the standard for detection of drugs of abuse, sweat patches provide a convenient alternative that avoids some of the problems with drug testing such as violations of privacy in observed urination, ..
  24. doi Sweat electrolyte concentrations obtained from within occlusive coverings are falsely high because sweat itself leaches skin electrolytes
    Louise B Weschler
    J Appl Physiol 105:1376-7. 2008
  25. ncbi Sweat conductivity and chloride titration for cystic fibrosis diagnosis in 3834 subjects
    Jose Luis Lezana
    Department of Paediatric Pulmonology and Respiratory Physiology, Hospital Infantil de Mexico, Dr Marquez 162, Col Doctores, CP 06720 Mexico DF, Mexico
    J Cyst Fibros 2:1-7. 2003
    b>Sweat test is the standard for cystic fibrosis (CF) diagnosis. Conductivity is an alternative method not yet approved, in spite of its good correlation with chloride concentration...
  26. ncbi The relationship between exercise intensity and the sweat lactate excretion rate
    Michael J Buono
    Department of Biology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 7251, USA
    J Physiol Sci 60:103-7. 2010
    The purpose of this study was to determine the effect of increases in exercise intensity on the sweat lactate concentration and lactate excretion rate...
  27. ncbi Sweat-testing: a review of current technical requirements
    M Beauchamp
    Montreal Children s Hospital, McGill University Medical Centre, Montreal, Quebec, Canada
    Pediatr Pulmonol 39:507-11. 2005
    b>Sweat-testing remains a key component of the diagnostic workup for cystic fibrosis. However, it is technically challenging, especially in young children...
  28. ncbi Blood, sweat, and fears: the autonomic architecture of emotion
    Robert W Levenson
    Department of Psychology, University of California, Berkeley, Berkeley, California 94720 1650, USA
    Ann N Y Acad Sci 1000:348-66. 2003
    ....
  29. ncbi Rapid desensitization with autologous sweat in cholinergic urticaria
    Takeshi Kozaru
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Hyogo, Japan
    Allergol Int 60:277-81. 2011
    The majority of patients with cholinergic urticaria presents with strong hypersensitivity to autologous sweat. Patients with severe cholinergic urticaria are frequently resistant to H(1) antagonists which are used in conventional ..
  30. ncbi Sweat iron and zinc losses during prolonged exercise
    Keith C DeRuisseau
    Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306 1493, USA
    Int J Sport Nutr Exerc Metab 12:428-37. 2002
    The purpose of this study was to examine the effects of a 2-hour exercise bout on sweat iron and zinc concentrations and losses in males and females...
  31. pmc Human excretion of bisphenol A: blood, urine, and sweat (BUS) study
    Stephen J Genuis
    Faculty of Medicine, University of Alberta, Edmonton, Canada
    J Environ Public Health 2012:185731. 2012
    ..this study was designed to assess the relative concentration of BPA in three body fluids-blood, urine, and sweat-and to determine whether induced sweating may be a therapeutic intervention with potential to facilitate ..
  32. ncbi Appearance of D2O in sweat after oral and oral-intravenous rehydration in men
    Holly Emmanuel
    Human Performance Laboratory, University of Connecticut, Storrs, Connecticut, USA
    J Strength Cond Res 25:2092-9. 2011
    ..Deuterium oxide (D2O) has been used to demonstrate that fluid ingested during exercise appears in sweat within 10 minutes...
  33. ncbi Topiramate reduced sweat secretion and aquaporin-5 expression in sweat glands of mice
    Lei Ma
    Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Life Sci 80:2461-8. 2007
    Decreased sweat secretion is a primary side effect of topiramate in pediatric patients, but the mechanism underlying this effect remains unclear...
  34. ncbi Effect of heat acclimation on sweat minerals
    Troy D Chinevere
    U S Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
    Med Sci Sports Exerc 40:886-91. 2008
    This study examined the impact of 10 d of exercise-heat acclimation on sweat mineral concentrations.
  35. ncbi Initial evaluation of a biochemical cystic fibrosis newborn screening by sequential analysis of immunoreactive trypsinogen and pancreatitis-associated protein (IRT/PAP) as a strategy that does not involve DNA testing in a Northern European population
    Olaf Sommerburg
    Division of Paediatric Pulmonology and Allergy and Cystic Fibrosis Center, Department of Paediatrics III, University of Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany
    J Inherit Metab Dis 33:S263-71. 2010
    ....
  36. ncbi Sweat testing in addicts under methadone treatment: an Italian experience
    N Fucci
    Istituto di Medicina Legale, Universita Cattolica del Sacro Cuore, L go F Vito, 1, 00168 Roma, Italy
    Forensic Sci Int 174:107-10. 2008
    In the last years the interest in monitoring drug exposure with human sweat as alternative biological fluid, is increasing. Sweat collection is convenient, less invasive and difficult to adulterate compared to traditional specimens...
  37. ncbi Accumulation of 2H2O in plasma and eccrine sweat during exercise-heat stress
    Lawrence E Armstrong
    Human Performance Laboratory, University of Connecticut, Storrs, CT 06269 1110, USA
    Eur J Appl Physiol 108:477-82. 2010
    ..Deuterium oxide ((2)H(2)O) accumulation in plasma and eccrine sweat was measured at two sites (back and forehead)...
  38. pmc Second-hand stress: inhalation of stress sweat enhances neural response to neutral faces
    Denis Rubin
    Department of Biomedical Engineering, Bioengineering Building, Room 119, Stony Brook, NY 11794 5281, USA
    Soc Cogn Affect Neurosci 7:208-12. 2012
    ..Chemosensory stimuli were obtained from the sweat of 64 male donors during both stress (first-time skydive) and control (exercise) conditions, indistinguishable by ..
  39. ncbi Early determination of cystic fibrosis by electrochemical chloride quantification in sweat
    Javier Gonzalo-Ruiz
    Centro Nacional de Microelectrónica IMB CNM, CSIC, Esfera UAB, Campus Universidad Autónoma de Barcelona, Bellaterra, Barcelona, Spain
    Biosens Bioelectron 24:1788-91. 2009
    A novel and rapid approach to quantify chloride concentration in sweat for early detection of cystic fibrosis (CF) is shown in this work...
  40. ncbi Comparison between classic Gibson and Cooke technique and sweat conductivity test in patients with and without cystic fibrosis
    Ana C V Mattar
    Unidade de Pneumologia, Instituto da Criança, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    J Pediatr (Rio J) 86:109-14. 2010
    To compare sweat chloride values obtained by quantitative pilocarpine iontophoresis (classic test) with the sweat conductivity values obtained using Macroduct collection system in patients with and without cystic fibrosis (CF)...
  41. ncbi Relation of sweat chloride concentration to severity of lung disease in cystic fibrosis
    Pamela B Davis
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Pediatr Pulmonol 38:204-9. 2004
    In cystic fibrosis (CF), sweat chloride concentration has been proposed as an index of CFTR function for testing systemic drugs designed to activate mutant CFTR...
  42. pmc Sweat testing in newborns positive to neonatal screening for cystic fibrosis
    G Taccetti
    Meyer Pediatric Hospital, University of Florence, Via L Giordano 13, Florence 50132, Italy
    Arch Dis Child Fetal Neonatal Ed 89:F463-4. 2004
    b>Sweat chloride concentrations above 40 mmol/l are unusual in newborns screened for cystic fibrosis and should be followed up...
  43. ncbi Behavioural responses of Anopheles gambiae sensu stricto to components of human breath, sweat and urine depend on mixture composition and concentration
    Y T Qiu
    Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands
    Med Vet Entomol 25:247-55. 2011
    ..In this study, behavioural responses of female An. gambiae to components of human breath, urine and sweat at a series of concentrations, or a single concentration in the case of acetone, were examined in combination with ..
  44. ncbi Phenotypic characterisation of patients with intermediate sweat chloride values: towards validation of the European diagnostic algorithm for cystic fibrosis
    C Goubau
    Department of Paediatrics, Paediatric Pulmonology, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Thorax 64:683-91. 2009
    In patients with symptoms suggestive of cystic fibrosis (CF) and intermediate sweat chloride values (30-60 mmol/l), extensive CFTR gene mutation analysis and nasal potential difference (NPD) measurement are used as additional diagnostic ..
  45. ncbi Measurements of sweat response and skin vasomotor reflex for assessment of autonomic dysfunction in patients with diabetes
    Masato Asahina
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Diabetes Complications 22:278-83. 2008
    Some physical or arousal stimuli induce a rise in sweat secretion (sympathetic sweat response or SSwR) and a reduction in skin blood flow (skin vasomotor reflex or SkVR) to the palm...
  46. pmc Indirect measurements of sweat electrolyte concentration in the laboratory diagnosis of cystic fibrosis
    M E Heeley
    East Anglian Biochemical Genetic and Neonatal Screening Unit, Peterborough District Hospital NHS Trust, Peterborough PE3 6DA, UK
    Arch Dis Child 82:420-4. 2000
    To investigate whether analytical methods based on the colligative physical chemical properties of ions or solutes in sweat are less effective than the specific measurement of electrolytes in the diagnosis of cystic fibrosis (CF).
  47. ncbi Parental understanding of newborn screening for cystic fibrosis after a negative sweat-test
    Colleen Walsh Lang
    Washington University in St Louis, St Louis, Missouri, USA
    Pediatrics 127:276-83. 2011
    ..Newborn screening for cystic fibrosis (CF) in Illinois uses an immunoreactive trypsinogen/DNA methodology; most false-positive results identify unaffected carriers...
  48. ncbi Reliability of sweat-testing by the Macroduct collection method combined with conductivity analysis in comparison with the classic Gibson and Cooke technique
    G Mastella
    Regional Cystic Fibrosis Center, Azienda Ospedaliera, Verona, Italy
    Acta Paediatr 89:933-7. 2000
    This study was to ascertain the reliability of sweat-testing by the Macroduct collection method combined with conductivity analysis (MCS) compared with the Gibson and Cooke technique (GCT)...
  49. ncbi Sweat analysis proficiency testing for cystic fibrosis
    V A Legrys
    Division of Clinical Laboratory Science, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7145, USA
    Pediatr Pulmonol 30:476-80. 2000
    The purpose of this report is to describe the College of American Pathologists sweat testing (SW) proficiency testing program for cystic fibrosis, to evaluate its impact on test performance, and to describe the current practice of sweat ..
  50. ncbi A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chloride concentrations
    W E Highsmith
    Applied Technology Genetics Corp, Malvern, PA
    N Engl J Med 331:974-80. 1994
    Many patients with chronic pulmonary disease similar to that seen in cystic fibrosis have normal (or nondiagnostic) sweat chloride values...
  51. ncbi Psychosocial risk associated with newborn screening for cystic fibrosis: parents' experience while awaiting the sweat-test appointment
    Audrey Tluczek
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719 1179, USA
    Pediatrics 115:1692-703. 2005
    ..The psychosocial effects on parents of infants with abnormal results in cystic fibrosis (CF) newborn screening (NBS) that uses genetic testing remain unclear...
  52. ncbi Particles, sweat, and tears: a comparative study on bioaccessibility of ferrochromium alloy and stainless steel particles, the pure metals and their metal oxides, in simulated skin and eye contact
    Yolanda Hedberg
    Division of Surface and Corrosion Science, School of Chemical Science and Engineering, Royal Institute of Technology KTH, Drottning Kristinas vag 51, SE 100 44 Stockholm, Sweden
    Integr Environ Assess Manag 6:456-68. 2010
    ..steel grade AISI 316L, pure Fe, pure Cr, iron(II,III)oxide, and chromium(III)oxide, upon immersion in artificial sweat (pH 6.5) and artificial tear (pH 8.0) fluids for various time periods...
  53. ncbi Conductivity determined by a new sweat analyzer compared with chloride concentrations for the diagnosis of cystic fibrosis
    Juerg Barben
    Division of Paediatric Pulmonology, Children s Hospital, St Gallen, Switzerland
    J Pediatr 146:183-8. 2005
    The aim of the study was to determine if a new conductivity measuring sweat test system (Nanoduct) could reliably identify patients with cystic fibrosis (CF) and differentiate them from healthy subjects.
  54. ncbi Dissolution of cemented carbide powders in artificial sweat: implications for cobalt sensitization and contact dermatitis
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop H 2800, Morgantown, WV 26505, USA
    J Environ Monit 12:1815-22. 2010
    ..of feedstock and process-sampled powders encountered in the production of hard metal alloys using artificial sweat. The physicochemical properties of each material were characterized prior to evaluation of dissolution behavior...
  55. ncbi [Standardized sweat chloride analysis for the diagnosis of cystic fibrosis in Korea]
    Sue Jung Kim
    Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea
    Korean J Lab Med 28:274-81. 2008
    ..It is quite common in Caucasians, but very rare in Asians. Sweat chloride test is known to be a screening test for the cystic fibrosis due to the fact that electrolyte levels in ..
  56. pmc Relationship of Q-sweat to quantitative sudomotor axon reflex test (QSART) volumes
    David M Sletten
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Muscle Nerve 41:240-6. 2010
    Q-Sweat, a commercial quantitative sweat measurement system, is modeled on quantitative sudomotor axon reflex testing (QSART)...
  57. ncbi Clinical phenotype and genotype of children with borderline sweat test and abnormal nasal epithelial chloride transport
    Isabelle Sermet-Gaudelus
    Centre de Référence et de Compétence en Mucoviscidose, Hopital Necker Enfants Malades, Paris, France
    Am J Respir Crit Care Med 182:929-36. 2010
    The diagnosis of cystic fibrosis (CF) is based on a characteristic clinical picture in association with a sweat chloride (Cl(-)) concentration greater than 60 mmol/L or the identification of two CF-causing mutations...
  58. pmc Excretion of beta-lactam antibiotics in sweat--a neglected mechanism for development of antibiotic resistance?
    N Hoiby
    Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Denmark
    Antimicrob Agents Chemother 44:2855-7. 2000
    ..of beta-lactam antibiotics after standard doses were measured in blood and apocrine (axilla) and eccrine (forearm) sweat from six adult healthy persons. All persons had ceftazidime (axilla, 28...
  59. ncbi Two-tiered immunoreactive trypsinogen-based newborn screening for cystic fibrosis in Colorado: screening efficacy and diagnostic outcomes
    Marci K Sontag
    Department of Preventive Medicine and Biometrics and the Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80218, USA
    J Pediatr 147:S83-8. 2005
    To examine immunoreactive trypsinogen (IRT)-based screening for cystic fibrosis (CF) for recall rate, genotype distribution, and "borderline" sweat test results.
  60. ncbi A finger sweat chloride test for the detection of a high-risk group of chronic pancreatitis
    Satoru Naruse
    Department of Internal Medicine, Nagoya University Graduate School of Medicine and Nagoya Institute of Technology, Nagoya, Japan
    Pancreas 28:e80-5. 2004
    ..We developed a simple method for measuring finger sweat chloride concentration to test whether CFTR dysfunction underlies chronic pancreatitis in Japan where cystic ..
  61. pmc Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade
    Azza Eissa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 286:687-706. 2011
    ..Herein, we elucidated for the first time KLK8 activity in human non-palmoplantar stratum corneum and sweat ex vivo...
  62. ncbi BOLD, sweat and fears: fMRI and skin conductance distinguish facial fear signals
    Leanne M Williams
    Brain Dynamics Centre, University of Sydney, Westmead Hospital, NSW, 2145, Australia
    Neuroreport 16:49-52. 2005
    ..The findings suggest that fear, anger and disgust perception involves specific interactions in the neural arousal systems for emotion and motivation...
  63. ncbi Dermcidin: a novel human antibiotic peptide secreted by sweat glands
    B Schittek
    Department of Dermatology, Eberhard Karls University Tubingen, Germany
    Nat Immunol 2:1133-7. 2001
    ..This protein was specifically and constitutively expressed in the sweat glands, secreted into the sweat and transported to the epidermal surface...
  64. ncbi Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites
    Siegbert Rieg
    Department of Dermatology, Eberhard Karls University Tubingen, Tubingen, Germany
    J Invest Dermatol 126:354-65. 2006
    ..Dermcidin (DCD), a recently discovered AMP with broad-spectrum activity, is produced constitutively by the eccrine sweat glands and secreted into sweat...
  65. ncbi Measurement of cytokines in sweat patches and plasma in healthy women: validation in a controlled study
    Andrea Marques-Deak
    Section on Neuroendocrine Immunology and Behavior Integrative Neural Immune Program, NIMH, NIH, MSC 9401 Rockville, Maryland 20852, USA
    J Immunol Methods 315:99-109. 2006
    ..has been applied to plasma, cervical secretions and other body fluids, but has not previously been applied to sweat. The aim of this study was to validate the RIC methodology in sweat for measurements of IL-1alpha, IL-1beta, IL-6, ..
  66. ncbi An indigenously developed method for sweat collection and estimation of chloride for diagnosis of cystic fibrosis
    S K Kabra
    Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110 029, India
    Indian Pediatr 39:1039-43. 2002
    An indigenously developed method for sweat collection and titration method for estimation of chloride was validated. The mean difference in estimated chloride value from the known strength of saline in 50 samples was -1.04 +/- 4...
  67. ncbi Sweat and sodium losses in NCAA football players: a precursor to heat cramps?
    John R Stofan
    Gatorade Sports Science Institute, Barrington, IL 60010, USA
    Int J Sport Nutr Exerc Metab 15:641-52. 2005
    ..6 y, 110 +/- 20 kg) who had never cramped (NC). Change in body weight (adjusted by fluid intake) determined gross sweat loss. Sweat samples (forearm patch) were analyzed for sodium and potassium concentrations...
  68. pmc Cystic fibrosis: terminology and diagnostic algorithms
    K De Boeck
    Department of Pediatrics, Pediatric Pulmonology, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Thorax 61:627-35. 2006
    ..Patients are diagnosed with classic or typical CF if they have one or more phenotypic characteristics and a sweat chloride concentration of >60 mmol/l. The vast majority of CF patients fall into this category...
  69. ncbi Transient correction of the basic defect in sweat glands in an individual with cystic fibrosis carrying the complex CFTR allele F508del-R553Q
    B Tummler
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Thorax 64:179-80. 2009
    ..b>Sweat chloride concentrations were normal early in life, but were later raised into the range that is diagnostic for ..
  70. ncbi Sweat gland bioelectrics differ in cystic fibrosis: a new concept for potential diagnosis and assessment of CFTR function in cystic fibrosis
    T Gonska
    Department of Paediatrics, University of Toronto, Toronto, Canada
    Thorax 64:932-8. 2009
    For nearly 50 years the diagnosis of cystic fibrosis (CF) has depended on measurements of sweat chloride concentration...
  71. ncbi Use of nasal potential difference and sweat chloride as outcome measures in multicenter clinical trials in subjects with cystic fibrosis
    Richard C Ahrens
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242 1083, USA
    Pediatr Pulmonol 33:142-50. 2002
    ..The use of outcome measures that assess CFTR function such as nasal potential difference (NPD) measurements and sweat chloride determinations will be required to evaluate the efficacy of such treatments in multicenter clinical ..
  72. ncbi An overview of the use of urine, hair, sweat and saliva to detect drug use
    Kate Dolan
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia
    Drug Alcohol Rev 23:213-7. 2004
    This paper provides a brief overview of qualitative drug testing procedures using urine, hair, saliva and sweat specimens...
  73. ncbi Artificial sweat enhances dermal transfer of chlorpyrifos from treated nylon carpet fibers
    Ryan L Williams
    Personal Chemical Exposure Program, Department of Entomology, University of California, Riverside, CA 92521, USA
    J Environ Sci Health B 40:535-43. 2005
    ..Prior to application, synthetic sweat was applied to skin in half of the cells...
  74. ncbi Positive emotional priming of facial affect perception in females is diminished by chemosensory anxiety signals
    Bettina M Pause
    Institute of Psychology, Christian Albrechts University, Olshausenstr 62, 24098 Kiel, Germany
    Chem Senses 29:797-805. 2004
    ..Axillary sweat samples were taken from 12 males while they were waiting for an academic examination and while exercising ..
  75. ncbi Quantification of eight tissue kallikreins in the stratum corneum and sweat
    Nahoko Komatsu
    J Invest Dermatol 126:925-9. 2006
  76. ncbi Sweat antigen induces histamine release from basophils of patients with cholinergic urticaria associated with atopic diathesis
    S Takahagi
    Department of Dermatology, Programs for Biomedical Research, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Br J Dermatol 160:426-8. 2009
    We previously demonstrated that the semipurified human sweat antigen causes skin reactions and histamine release from basophils via specific IgE in patients with atopic dermatitis (AD)...
  77. ncbi Olfaction: mosquito receptor for human-sweat odorant
    Elissa A Hallem
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nature 427:212-3. 2004
    ..AgOr1, a female-specific member of a family of putative odorant receptors, responds to a component of human sweat. Compounds designed to activate or block receptors of this type could function as attractants for trapping ..
  78. ncbi Release of doxorubicin in sweat: first step to induce the palmar-plantar erythrodysesthesia syndrome?
    U Jacobi
    Ann Oncol 16:1210-1. 2005
  79. pmc Cystic fibrosis in Korean children:a case report identified by a quantitative pilocarpine iontophoresis sweat test and genetic analysis
    Kang Mo Ahn
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 20:153-7. 2005
    ..The sweat chloride concentrations of the first patient were 108.1 mM/L and 96.7 mM/L...
  80. pmc Latherin: a surfactant protein of horse sweat and saliva
    Rhona E McDonald
    Ecology and Evolutionary Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 4:e5726. 2009
    Horses are unusual in producing protein-rich sweat for thermoregulation, a major component of which is latherin, a highly surface-active, non-glycosylated protein...
  81. ncbi Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L
    Daniel Baechle
    Medical and Natural Sciences Research Center, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany
    J Biol Chem 281:5406-15. 2006
    The protein pattern of healthy human eccrine sweat was investigated and 10 major proteins were detected from which apolipoprotein D, lipophilin B, and cathepsin D (CatD) were identified for the first time in human eccrine sweat...
  82. ncbi Uric acid and urea in human sweat
    Chien Tsai Huang
    Institute of Public Health, National Yang Ming University, Taipei, Taiwan, ROC
    Chin J Physiol 45:109-15. 2002
    ..Concentrations of uric acid and urea were measured in the sweat of sixteen male volunteers, who were treated with external heat after one hour of intense physical exercise...
  83. ncbi Comparison of daily urine, sweat, and skin swabs among cocaine users
    D A Kidwell
    Chemistry Division, Naval Research Laboratory, Washington, DC 20375, USA
    Forensic Sci Int 133:63-78. 2003
    This study (1) compares urine, skin swabs, and PharmChek sweat patches for monitoring drug use; (2) measures possible environmental contamination in recent cocaine (COC) users; and (3) evaluates various immunoassays (IA) for screening ..
  84. ncbi Variations in regional sweat composition in normal human males
    M J Patterson
    Scottish School of Sport Studies, University of Strathclyde, Glasgow, UK
    Exp Physiol 85:869-75. 2000
    This project aimed to quantify the regional distribution of sweat composition over the skin surface and to determine whether sweat constituent concentrations collected from regional sites can estimate whole-body concentrations...
  85. ncbi Sweat ethanol concentrations are highly correlated with co-existing blood values in humans
    M J Buono
    Department of Biology and the Department of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, USA
    Exp Physiol 84:401-4. 1999
    This study compared the concentration of ethanol, both absolute and relative to water content, in sweat and blood. Ten male volunteers consumed approximately 13 mmol (kg body weight)-1 of ethanol...
  86. pmc Why do we have apocrine and sebaceous glands?
    A M Porter
    Redcrest, Health Rise, Camberley, Surrey GU15 2ER, UK
    J R Soc Med 94:236-7. 2001
    ..In hot conditions the secretions emulsify eccrine sweat and thus encourage the formation of a sweat sheet and discourage the formation and loss of sweat drops from the ..
  87. ncbi Effect of age and gender on sweat lactate and ammonia concentrations during exercise in the heat
    F Meyer
    Laboratório de Pesquisa do Exercício, Escola de Educação Física, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Braz J Med Biol Res 40:135-43. 2007
    The dependence of sweat composition and acidity on sweating rate (SR) suggests that the lower SR in children compared to adults may be accompanied by a higher level of sweat lactate (Lac-) and ammonia (NH3) and a lower sweat pH...
  88. ncbi Plasma, oral fluid and sweat wipe ecstasy concentrations in controlled and real life conditions
    Nele Samyn
    Drugs and Toxicology, Section Toxicology, National Institute of Criminalistics and Criminology, Vilvoordsesteenweg 100, 1120 Brussels, Belgium
    Forensic Sci Int 128:90-7. 2002
    ..Toxicokinetic data were gathered by analysis of blood, urine, oral fluid and sweat wipes collected during the first 5h after administration...
  89. ncbi Variant cystic fibrosis phenotypes in the absence of CFTR mutations
    Joshua D Groman
    McKusick Nathans Institute of Genetic Medicine and Cystic Fibrosis Foundation Genotyping Center, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 347:401-7. 2002
    ..involves characteristic findings in the respiratory tract, gastrointestinal tract, male reproductive tract, and sweat glands and is caused by loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (..
  90. ncbi Human sweat and 2-oxopentanoic acid elicit a landing response from Anopheles gambiae
    T P Healy
    Wye College, University of London, Kent, UK
    Med Vet Entomol 14:195-200. 2000
    A wind tunnel bioassay and video to observe mosquitoes landing on heated glass cylinders were used to test sweat and some derivatives for responses of Anopheles gambiae Giles (Diptera: Culicidae), a highly anthropophilic African species ..
  91. ncbi Electroantennogram and behavioural responses of the malaria vector Anopheles gambiae to human-specific sweat components
    C Costantini
    Istituto di Parassitologia, University of Rome, La Sapienza, Rome, Italy
    Med Vet Entomol 15:259-66. 2001
    ..gambiae sensu stricto, are attracted mainly to human hosts. A major source of human volatile emissions is sweat, from which key human-specific components are the carboxylic acids (E)- and (Z)-3-methyl-2-hexenoic acid and 7-..
  92. ncbi Effects of high and low blood lactate concentrations on sweat lactate response
    J M Green
    Department of Physical Education and Recreation, Western Kentucky University, Bowling Green 42101, USA
    Int J Sports Med 21:556-60. 2000
    b>Sweat lactate results from eccrine gland metabolism, however, the possible clearance of blood lactate through sweat has not been resolved...
  93. ncbi Secretory proteins as potential semiochemical carriers in the horse
    Barbara D'Innocenzo
    Dipartimento di Chimica e Biotecnologie Agrarie, Universita di Pisa, 56124 Pisa, Italy
    Biochemistry 45:13418-28. 2006
    Two soluble proteins were isolated as major secretory products of horse sweat and of the parotid gland and characterized for structural and functional properties...
  94. ncbi Equine sweating and anhidrosis Part 1--equine sweating
    David McEwan Jenkinson
    Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Vet Dermatol 17:361-92. 2006
    ..This review is focused specifically on the thermoregulatory role of sweat in Equidae and the causes of sweating failure (anhidrosis)...
  95. ncbi Diagnostic sweat testing: the Cystic Fibrosis Foundation guidelines
    Vicky A LeGrys
    Division of Clinical Laboratory Science, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7145, USA
    J Pediatr 151:85-9. 2007
  96. ncbi Dissolution of materials in artificial skin surface film liquids
    Aleksandr B Stefaniak
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Toxicol In Vitro 20:1265-83. 2006
    ..To provide meaningful results, the composition of artificial SSFL should accurately mimic human sweat and sebum, and the conditions of the in vitro test system should accurately reflect in vivo skin conditions...
  97. ncbi Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo
    Siegbert Rieg
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    J Immunol 174:8003-10. 2005
    ..It is constitutively expressed in human eccrine sweat glands and secreted into sweat...
  98. ncbi Detection of dermcidin-derived peptides in sweat by ProteinChip technology
    Thomas Flad
    Section for Transplantation Immunology and Immunohaematology, University of Tuebingen, Waldhoernlestr 22, 72072, Tuebingen, Germany
    J Immunol Methods 270:53-62. 2002
    Recently, a novel antimicrobial peptide DCD-1, derived from the Dermcidin (DCD) gene and secreted by sweat glands, has been described by Schittek et al. [Nat. Immunol. 2 (2001) 1133.]...
  99. ncbi Elevated sweat sodium associated with pulmonary oedema in meningococcal sepsis
    M Eisenhut
    University of Liverpool, Liverpool, UK
    Eur J Clin Invest 34:576-9. 2004
    We observed a temporary positive sweat test with sodium and chloride levels greater than 60 mmol L(-1) following meningococcal septicaemia...
  100. pmc Protracted neonatal hypertrypsinogenaemia, normal sweat chloride, and cystic fibrosis
    C Castellani
    Cystic Fibrosis Centre, Ospedale Civile Maggiore, Piazzale Stefani 1, 37126 Verona, Italy
    Arch Dis Child 82:481-2. 2000
    ..fibrosis (CF) clinical spectrum has greatly expanded in the past few years, including atypical forms with low sweat chloride concentrations...
  101. ncbi Negative sweat test in hypertrypsinaemic infants with cystic fibrosis carrying rare CFTR mutations
    Rita Padoan
    Cystic Fibrosis Centre, A O Istituti Clinici di Perfezionamento, Milano, Italy
    Eur J Pediatr 161:212-5. 2002
    ..Diagnosis is confirmed by a positive sweat test and/or by the presence of two mutations in the cystic fibrosis transmembrane regulator gene...

Research Grants64

  1. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2013
    ..Important cellular functions of Orai1 have been identified in lymphocytes, mast cells, blood platelets, sweat and salivary glands, dentition, vascular smooth muscle, endothelial cells, and skeletal muscle...
  2. Sodium Chloride Cotransporter Regulation by WNK Kinase
    Hui Cai; Fiscal Year: 2010
    ..are present in a variety of polarized epithelia involved in chloride ion transport, such as kidney, clonic crypts, sweat ducts, pancreatic ducts, biliary ducts, epididymis and the ependyma of the brain...
  3. MECHANISM OF PATHOGENIC ACTIVITY OF PEPTIDOGLYCAN
    Roman Dziarski; Fiscal Year: 2012
    ..are expressed on the skin, in the eyes, on mucous membranes in the oral cavity and gastrointestinal tract, and in sweat, sebum, saliva, and polymorphonuclear leukocytes...
  4. Skin Temperature Perception and Prosthetic Thermoregulation
    GLENN KLUTE; Fiscal Year: 2012
    ..are constructed are extremely effective insulators and impermeable to moisture;trapping heat and accumulating sweat inside the prosthesis...
  5. Regional Cystic fibrosis DNA Mutation Analysis
    JANE P GETCHELL; Fiscal Year: 2010
    ..Positive predictive values will improve and the need for sweat testing will be minimized within the region...
  6. HCO3- Conductive function of CFTR: Implications to Oral Health & Cystic Fibrosis
    MADIREDDI REDDY; Fiscal Year: 2010
    ..component of secretions from exocrine glands such as salivary glands, pancreas, duodenum, reproductive organs, sweat glands and the airways...
  7. LIVE-CELL IMAGING OF CFTR OLIGOMERIZATION, TRAFFICKING AND INTERACTIONS
    PETER MICHAEL HAGGIE; Fiscal Year: 2012
    ..ion channel present in the apical surface of several epithelia including the airways, pancreas, kidney, sweat glands and gastrointestinal tract...
  8. Walkability's Impact on Senior Health
    Allen Glicksman; Fiscal Year: 2012
    ..The first is to use the Senior Walking Environment Assessment Tool- Revised (SWEAT-R) protocol to look at micro-level design elements in the APM service area...
  9. CRAC Channel Deficiency in Immunity to Infection
    Stefan Feske; Fiscal Year: 2013
    ..that is characterized by severe infections, autoimmunity, muscular hypotonia and defects in tooth formation and sweat gland function...
  10. International Conference for Ectodermal Dysplasias Classification
    Carlos F Salinas; Fiscal Year: 2012
    ..He based his classification on the observed clinical phenotype affecting mainly the hair, teeth, sweat pores and nails...
  11. MOLECULAR GENETICS OF CYSTIC FIBROSIS
    Garry R Cutting; Fiscal Year: 2012
    ..and electrolyte transport that primarily affects the lung, pancreas, intestine, male reproductive tract and the sweat gland. Positional cloning identified CF Transmembrane conductance Regulator (CFTR) as the gene responsible for CF...
  12. Theoretical study of structure-function correlations of Aquaporin V and mutants
    LIAO Y CHEN; Fiscal Year: 2013
    ..AQP0-AQP12) distributed within cells of the stomach, duodenum, pancreas, airways, lungs, salivary glands, sweat glands, eyes, lacrimal glands, and the inner ear, AQP5 has been implicated in Sjogren's disease and in ..
  13. A non-invasive nanotechnology-based skin patch for multiplexed diagnostics
    LANCE ALLEN LIOTTA; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Sweat is an unexploited biological fluid that can provide a wealth of diagnostic information...
  14. Structure &Function in Diabetic Small Fiber Neuropathy
    Christopher H Gibbons; Fiscal Year: 2012
    ..Damage to cutaneous autonomic nerve fibers leads to reduced sweat production and development of dry, cracked skin;a potential nidus for infection...
  15. The Role of Presenilin in Hidradenitis Suppurativa
    Airong Li; Fiscal Year: 2013
    ..HS affects the apocrine sweat glands that often results in chronically draining sinus tracks and wounds...
  16. A Device to Quantify Sweat of Single Sweat Glands to Diagnose Neuropathy
    William R Kennedy; Fiscal Year: 2013
    ..Our sensitive sweat test (SST) detects early dysfunction of sudomotor nerves that activate sweat glands (SGs) by measuring the rate ..
  17. Receptors and Neurons Mediating Acid Taste in Drosophila
    ANUPAMA ARUN DAHANUKAR; Fiscal Year: 2013
    ..Notably, carboxylic acids of low volatility are components of human sweat and their detection by taste neurons may be important for behaviors of human blood-feeding insects such as Aedes ..
  18. gp130 Cytokines, Diabetic Autonomic Neuropathy, and Nerve Regeneration
    Richard E Zigmond; Fiscal Year: 2012
    ..In addition, we will use the sympathetic innervation of sweat glands to look at regen- eration in vivo and return of autonomic function in diabetes...
  19. Disruption of Host-Seeking Behavior in Anopheles Gambiae Mosquitoes using Odorant
    Anandasankar Ray; Fiscal Year: 2012
    ..As the mosquito navigates closer using the CO2 plumes, it is also thought to be attracted to skin and sweat associated odors...
  20. Heat Effect on Generic Transdermal Drug Delivery Systems
    Audra L Stinchcomb; Fiscal Year: 2013
    ..by a number of factors including: skin condition, occlusion, exposure to heat, different inactive ingredients, sweat, age and patch design (reservoir vs. matrix)...
  21. MOLECULAR GENETICS OF CYSTIC FIBROSIS
    Garry R Cutting; Fiscal Year: 2013
    ..secretions in the pulmonary airways and pancreatic ducts and maintaining the correct concentration of chloride in sweat. Recently, treatment of CF has taken a major step forward with successful clinical trials of Kalydeco (VX-770), a ..
  22. A Device to Quantify Sweat of Single Sweat Glands to Diagnose Neuropathy
    William R Kennedy; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Neuro Devices, Inc. will construct a dynamic sweat test (DST) for early detection of peripheral neuropathy...
  23. Drug Screening with Nano-Porous Silicon Optical Biosensors
    LISA BONANNO; Fiscal Year: 2010
    ..assay worked out in Aim 1 into a bioactive hydrogel-PSi sensor composite device which can be developed into future sweat patch applications...
  24. Nanotrap technology for one step preservation and amplification of cancer biomark
    LANCE ALLEN LIOTTA; Fiscal Year: 2013
    ..We will extend the technology to urine and sweat to open up these biofluids as a new category for biomarker research, using innovative approaches to solve ..
  25. Epidemiology of drugs and HIV sex risk among Latino migrants
    Patricia J Kissinger; Fiscal Year: 2010
    ..affecting initiation and continuation of drug use among Latino migrant workers using mixed methods and applying Sweat and Dennison's model of HIV causation and Handwerker's theory of culture as guides, 3) To describe the ..
  26. Structural-environmental factors, alcohol and HIV risk in Latino migrant laborers
    Kurt C Organista; Fiscal Year: 2013
    ..Our conceptual model draws upon Sweat and Dennison's multi-level model of AIDS causation, and Diaz et al...
  27. Mechanisms, Structure, and Regulation of CFTRs NBDs
    David C Gadsby; Fiscal Year: 2013
    ..called CFTR) that normally helps move salt across the surfaces of cells in the lungs, intestines, pancreas, and sweat ducts...
  28. Isolation and characterization of new adult stem cells from sweat glands.
    Krzysztof Kobielak; Fiscal Year: 2013
    ..adult stem cells system still very little is known about the other stem cells in different skin appendages like sweat glands...
  29. Real Time Methods for Quantifying Exposure to Illicit Drugs & Psychosocial Stress
    Gregory D Kirk; Fiscal Year: 2010
    ..through retrospective audio-computer assisted structure interview (ACASI) and from biological specimens (hair and sweat), and stress will be assessed through ACASI and physiological measures (heart rate and allostatic load)...
  30. Regulation of Epithelial Sodium Channel by CFTR chloride channel
    Bakhrom Berdiev; Fiscal Year: 2009
    ..Affected organs include sweat glands, intestine, and the reproductive system, with the most devastating consequences when the disease affects ..
  31. Genetic Characterization of Essential Hyperhidrosis
    Gary Swergold; Fiscal Year: 2003
    ..Patients with EH sweat profusely and, as a result, have difficulty with many activities of normal daily living, including social ..
  32. Clinical Pharmacology of 3,4-Methylenedioxy Amphetamines
    John E Mendelson; Fiscal Year: 2010
    ..sensitive and specific analytic methods to measure the isomers of MDMA and metabolites in plasma, urine and sweat (using patches and a ventilated capsule method, useful in biomonitoring of MDMA abuse)...
  33. ION CHANNEL REGULATION IN CYSTIC FIBROSIS
    JEFFREY WINE; Fiscal Year: 1990
    ..The carrier frequency in the U.S. Caucasian population is about 1 in 23. The clinical syndrome includes elevated sweat electrolytes, pancreatic insufficiency, thickened cervical mucus in females and blockage and eventual degeneration ..
  34. MECHANISMS OF DRUG DEPOSITION IN HAIR
    JAMES RUTH; Fiscal Year: 2002
    ..externally on the hair versus drugs ingested and deposited via the systemic circulation; 3) the effects of sweat and sebum on quantitation of hair drug levels; 4) correlation between ingested drug and distribution into hair; ..
  35. DERMAL CHOLINERGIC RECEPTORS AND ALZHEIMER'S DISEASE
    HELENA RYER; Fiscal Year: 1992
    ..These studies are designed to increase our understanding of the basic mechanisms that control the human eccrine sweat gland's response to its sympathetic cholinergic innervation and to extend our knowledge of cholinergic deficits in ..
  36. A NEW CHLORIDE SWEAT TEST FOR CYSTIC FIBROSIS SCREENING
    WARREN WARWICK; Fiscal Year: 2004
    The CF Quantum(r) sweat test system is a rapid, easily administered, cost effective method to diagnose cystic fibrosis (CF)...
  37. Functional analysis of the CYLD tumor suppressor
    JULIDE CELEBI; Fiscal Year: 2009
    ..suppression results in severe defects in the development of epidermal appendages including hair follicles and sweat glands. In addition, abnormalities in NF-KB signaling play a role in epidermal neoplasia...
  38. REGULATION OF EPIDERMAL DIFFERENTATION BY PTHRP
    John Foley; Fiscal Year: 2004
    ..The dermis also signals the epidermis to produce hair, sweat glands, and nails in their proper places...
  39. The postmenopausal hot flash: cutaneous and hemodynamic mechanisms
    CRAIG CRANDALL; Fiscal Year: 2009
    ..recordings of postganglionic skin sympathetic nerve activity (SSNA) concurrently with skin blood flow and sweat rate measurements SPECIFIC AIM #1 will test the hypothesis that SSNA increases, concomitant with elevations in ..
  40. CL-/HCO3- EXCHANGE IN CYSTIC FIBROSIS SWEAT GLANDS
    Paul Quinton; Fiscal Year: 2001
    ..The link between these two defects is not known, but the human sweat duct offers a unique opportunity to observe normal and defective C1-and HCO3 ion-transport in a native human ..
  41. A Canine Model for Human X-Linked Ectodermal Dysplasia
    Margret Casal; Fiscal Year: 2007
    ..pathologic, and genetic features of X-linked ectodermal dysplasia (HED) characterized by hypoplasia of hair and sweat glands, and missing and malformed teeth...
  42. Protease Regulation of Airway Cell Sodium Transport
    Robert Bridges; Fiscal Year: 2005
    ..and plays an important role in the physiology of a number of organs including the kidney, colon, sa1ivary, and sweat glands as well as the lungs...
  43. NEUROPSYCHOPHARMACOLOGY OF ALTERED CONSCIOUSNESS
    Reese Jones; Fiscal Year: 2007
    ..The pharmacokinetics of deuterium-labeled methamphetamine and tetrahydrocannabinol in hair and sweat will be characterized to better understand mechanisms and utility of hair and sweat for biomarkers of drug ..
  44. ECCRINE SWEAT GLAND FUNCTION AND CYSTIC FIBROSIS
    Kenzo Sato; Fiscal Year: 2000
    The eccrine sweat gland is one of the target organs in cystic fibrosis (CF). The CF gene has been cloned and identified as cAMP-dependent Cl channel in other laboratories...
  45. DOWNLESS GENE AND ITS ROLE IN INDUCTIVE SIGNALING
    PAUL OVERBEEK; Fiscal Year: 2002
    ..mutants, downless, Tabby, and crinkled, that all show identical defects in ectodermal induction of hair follicles, sweat glands, and Meibomian glands...
  46. NEUROPHYSIOLOGICAL CHANGES IN ADULTS EXPOSED TO SOLVENTS
    Allene Scott; Fiscal Year: 1999
    ..vibratory and thermal computerized Quantitative Sensory Testing (QST) and the Sudomotor Axon Reflex Test (Q-SART) sweat response in 20 solvent-exposed patients and 20 non-exposed controls...
  47. TRANFORMED CYSTIC FIBROSIS CELLS--ASSAYS FOR THE GENE
    Manuel Buchwald; Fiscal Year: 1990
    ..Primary cultures derived from a total of 12 sweat glands and nasal polyps will be infected with an adeno- SV40 recombinant virus and the transformed cells isolated ..
  48. ENaC & CFTR: Molecular Interactions in Health & Disease
    MADIREDDI REDDY; Fiscal Year: 2006
    ..Regulator) chloride channel are expressed in the apical membranes of epithelial cells in salivary gland ducts, sweat duct, kidney, distal colon, and airways...
  49. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
    ..150 described ectodermal dysplasias, is a disorder characterized by abnormal development of hair, teeth, sweat glands and salivary glands...
  50. CELL AND MOLECULAR BIOLOGY OF SECRETARY CL CHANNELS
    Dale Benos; Fiscal Year: 1993
    ..for Cl- secretion and, thus, influences the composition of the secretory products of the airways, pancreas, and sweat glands, the major target organs in CF...
  51. Phase 2 study of VX-770 in Cystic Fibrosis Subjectswith G551D
    CLAUDIA ORDONEZ; Fiscal Year: 2007
    ..Primary endpoints will be safety and tolerability. Secondary endpoints will be nasal potential difference (NPD), sweat chloride, forced expiratory volume in 1 second (FEV1), and pharmacokinetic parameters...
  52. Mentored Patient-Oriented Research Career Development Aw
    Paola Sandroni; Fiscal Year: 2004
    ..It is also possible to study the sympathetic supply to eccrine sweat gland and unmyelinated somatic fiber innervation of the skin (positive in IAN, negative in PAF) using punch skin ..
  53. HAIR ANALYSIS FOR DRUGS OF ABUSE
    Gary Henderson; Fiscal Year: 1993
    ..Sequential plasma, urine, sweat, and hair samples will be collected, then analyzed by GC/MS...
  54. PHARMACOKINETICS OF DRUGS OF ABUSE IN SKIN AND HAIR
    Reese Jones; Fiscal Year: 2000
    ..The pharmacokinetics of cocaine and methamphetamine in hair, skin, sweat and sebum, and plasma will be characterized so as to better understand mechanisms by which drugs enter hair...
  55. Detecting Crack and Other Cocaine Use With FastPatches
    HILARY LIBERTY; Fiscal Year: 2005
    PharmChem Inc. has developed a new sweat patch product, the FastPatch TM, which reduces minimum wear times to detect cocaine and most other drugs of abuse from the full day typically required with standard sweat patches (Liberty et al...
  56. HEAT STRESS AND THERMOREGULATION: AGE AND GENDER EFFECTS
    W Kenney; Fiscal Year: 1991
    ..of decreased aerobic capacity, as opposed to age-related changes in neural function, functional capacity of the sweat gland, etc. Statistically, more older women than men are victims of heat- related illness...
  57. MOLECULAR AND CELLULAR BIOLOGY OF CYSTIC FIBROSIS
    John Riordan; Fiscal Year: 1993
    ..a CF research Development Program directed primarily at the molecular cloning of the CF gene and its expression in sweat gland epithelial cell culture systems...
  58. ROLE OF SULFATION IN THE PATHOLOGY OF CYSTIC FIBROSIS
    Elias Meezan; Fiscal Year: 1991
    ..be a primary disorder of membrane ion transport characterized by increased sodium and chloride concentrations in sweat, altered S042- levels in tissue may be a primary or secondary consequence of the electrolyte abnormalities of this ..
  59. Developing a Family-Centered Approach for Genetic Counseling: A New Paradigm
    Audrey Tluczek; Fiscal Year: 2009
    ..self-reported measures: a) levels of emotional distress pre/post-counseling;b) knowledge about the screening and sweat test results, genetics of CF, and reproductive implications of being a CF carrier, all measured pre/post-..
  60. CFTR GENOTYPING BY PEPTIDE MASS-SIGNATURE GENOTYPING
    Edwin Naylor; Fiscal Year: 2001
    ..being challenged because the traditional battery of assays - immune reactive trypsinogen, Delta F508 analysis, and sweat chloride testing - are proving to be less reliable than previously thought...
  61. Utilization of Decentralized HIV Clinical Services in Rural Maharashtra, India
    GITA A SINHA; Fiscal Year: 2010
    ..Shruti Mehta, David Peters , Michael Sweat, and Kelly Gebo, Dr...
  62. A Novel Drugs-of-Abuse Longitudinal Abstinence Monitor
    JEFFREY REGAN; Fiscal Year: 2001
    ..The collection component consists of a patch that continuously collects drugs excreted transdermally via sweat and other means. The collection component immediately transfers the collected material to a detection component...
  63. IMMORTAL SWEAT GLAND CELLS FOR CYSTIC FIBROSIS RESEARCH
    Paul Quinton; Fiscal Year: 1993
    ..The goal of the research in the proposed project is to establish immortal cell lines from the human eccrine sweat gland for use as a model system for studying the basic physiological and biochemical defects in CF...
  64. HUMAN SWEAT DUCT--IN VITRO MODEL
    Dorr Dearborn; Fiscal Year: 1993
    ..is to develop and characterize long- term cultures of the cells from the reabsorptive duct of human eccrine sweat glands, from CF patients and controls, with documentation that these cell lines express the CF and control ..