semen

Summary

Summary: The thick, yellowish-white, viscid fluid secretion of male reproductive organs discharged upon ejaculation. In addition to reproductive organ secretions, it contains SPERMATOZOA and their nutrient plasma.

Top Publications

  1. ncbi Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen
    Anton Poliakov
    Department of Surgery Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Prostate 69:159-67. 2009
  2. pmc Transglutaminase-mediated semen coagulation controls sperm storage in the malaria mosquito
    David W Rogers
    Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom
    PLoS Biol 7:e1000272. 2009
  3. pmc Proteomics and comparative genomic investigations reveal heterogeneity in evolutionary rate of male reproductive proteins in mice (Mus domesticus)
    Matthew D Dean
    Department of Ecology and Evolutionary Biology, University of Arizona, AZ, USA
    Mol Biol Evol 26:1733-43. 2009
  4. pmc Towards a semen proteome of the dengue vector mosquito: protein identification and potential functions
    Laura K Sirot
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
    PLoS Negl Trop Dis 5:e989. 2011
  5. ncbi Urine bisphenol-A (BPA) level in relation to semen quality
    De Kun Li
    Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, California, USA
    Fertil Steril 95:625-30.e1-4. 2011
  6. ncbi World Health Organization reference values for human semen characteristics
    Trevor G Cooper
    Centre of Reproductive Medicine and Andrology of the University, Domagkstrasse 11, Munster, Germany
    Hum Reprod Update 16:231-45. 2010
  7. pmc Perinatal exposure to low doses of dioxin can permanently impair human semen quality
    Paolo Mocarelli
    University Department of Laboratory Medicine, Hospital of Desio, Monza Brianza, Italy
    Environ Health Perspect 119:713-8. 2011
  8. ncbi Sex-peptides: seminal peptides of the Drosophila male
    E Kubli
    Zoological Institute, University Zurich Irchel, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Cell Mol Life Sci 60:1689-704. 2003
  9. ncbi Environmental factors and semen quality
    Joanna Jurewicz
    Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland
    Int J Occup Med Environ Health 22:305-29. 2009
  10. pmc Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection
    Nadia R Roan
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    Cell Host Microbe 10:541-50. 2011

Detail Information

Publications306 found, 100 shown here

  1. ncbi Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen
    Anton Poliakov
    Department of Surgery Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Prostate 69:159-67. 2009
    ..Prostasomes have also been reported to present with sizes varying from 50 to 500 nm and to have multilayered lipid membranes; however, the fine morphology of prostasomes has never been studied in detail...
  2. pmc Transglutaminase-mediated semen coagulation controls sperm storage in the malaria mosquito
    David W Rogers
    Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom
    PLoS Biol 7:e1000272. 2009
    ..seminal proteins mediated by a MAG-specific transglutaminase (TGase), a mechanism remarkably similar to mammalian semen coagulation...
  3. pmc Proteomics and comparative genomic investigations reveal heterogeneity in evolutionary rate of male reproductive proteins in mice (Mus domesticus)
    Matthew D Dean
    Department of Ecology and Evolutionary Biology, University of Arizona, AZ, USA
    Mol Biol Evol 26:1733-43. 2009
    ..In contrast, proteins from the other five tissues showed significantly lower nonsynonymous substitution, revealing a previously unappreciated level of evolutionary constraint acting on the majority of male reproductive proteins...
  4. pmc Towards a semen proteome of the dengue vector mosquito: protein identification and potential functions
    Laura K Sirot
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
    PLoS Negl Trop Dis 5:e989. 2011
    ..As an initial step in identifying new targets for dengue vector control, we sought to identify the suite of proteins that comprise the Ae. aegypti ejaculate and determine which are transferred to females during mating...
  5. ncbi Urine bisphenol-A (BPA) level in relation to semen quality
    De Kun Li
    Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, California, USA
    Fertil Steril 95:625-30.e1-4. 2011
    To determine whether urine bisphenol-A (BPA) levels are associated with lower semen quality.
  6. ncbi World Health Organization reference values for human semen characteristics
    Trevor G Cooper
    Centre of Reproductive Medicine and Andrology of the University, Domagkstrasse 11, Munster, Germany
    Hum Reprod Update 16:231-45. 2010
    b>Semen quality is taken as a surrogate measure of male fecundity in clinical andrology, male fertility, reproductive toxicology, epidemiology and pregnancy risk assessments...
  7. pmc Perinatal exposure to low doses of dioxin can permanently impair human semen quality
    Paolo Mocarelli
    University Department of Laboratory Medicine, Hospital of Desio, Monza Brianza, Italy
    Environ Health Perspect 119:713-8. 2011
    In recent decades, young men in some industrialized areas have reportedly experienced a decrease in semen quality.
  8. ncbi Sex-peptides: seminal peptides of the Drosophila male
    E Kubli
    Zoological Institute, University Zurich Irchel, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Cell Mol Life Sci 60:1689-704. 2003
    ..Sps bind to sperm. Together with sperm they are responsible for the persistence of the two post-mating responses. But Sps are the molecular basis of the sperm effect; sperm is merely the carrier...
  9. ncbi Environmental factors and semen quality
    Joanna Jurewicz
    Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland
    Int J Occup Med Environ Health 22:305-29. 2009
    ..This article aims at evaluating the impact of environmental exposures (pesticides, phthalates, PCBs, air pollution, trihalomethanes (THMs), mobile phones) on semen quality, by reviewing most recent published literature.
  10. pmc Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection
    Nadia R Roan
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    Cell Host Microbe 10:541-50. 2011
    b>Semen serves as a vehicle for HIV and promotes sexual transmission of the virus, which accounts for the majority of new HIV cases...
  11. pmc Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia
    Guntram Bezold
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Fertil Steril 87:1087-97. 2007
    To determine the prevalence of pathogens that cause sexually transmitted infections (STIs) in semen from asymptomatic male infertility patients with and without leukocytospermia (LCS), and associations between STIs, inflammatory markers, ..
  12. ncbi Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor
    J Malm
    Section for Clinical Chemistry, Department of Laboratory Medicine, Lund University, University Hospital Malmo, Malmo, Sweden
    Prostate 45:132-9. 2000
    In semen, prostate-specific antigen (PSA or hK3) digests the gel proteins semenogelin I and II, resulting in liquefaction and the release of motile spermatozoa...
  13. ncbi Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men
    Tina Kold Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 82:863-70. 2004
    To examine the relationship between body mass index (BMI) and semen quality among young men from the general population.
  14. pmc HIV-1 enhancing effect of prostatic acid phosphatase peptides is reduced in human seminal plasma
    Julie A Martellini
    Department of Molecular Biology and Microbiology, Biomolecular Science Center, Burnett School of Biomedical Sciences at the University of Central Florida College of Medicine, Orlando, Florida, United States of America
    PLoS ONE 6:e16285. 2011
    ....
  15. pmc MicroRNA markers for forensic body fluid identification obtained from microarray screening and quantitative RT-PCR confirmation
    Dmitry Zubakov
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Legal Med 124:217-26. 2010
    ..miRNA markers for forensic body fluid identification, we first screened total RNA samples derived from saliva, semen, vaginal secretion, and venous and menstrual blood for the expression of 718 human miRNAs using a microarray ..
  16. pmc Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis
    Paul J Peters
    Center for AIDS Research, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Biotech II Suite 315, Worcester, MA 01605, USA
    J Virol 80:6324-32. 2006
    ..Envelopes were amplified (i) from blood and semen of adult patients and (ii) from plasma of pediatric patients...
  17. pmc Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli
    Deirdre E O'Hanlon
    Mucosal Protection Laboratory, Thomas C, Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 10:120. 2010
    ..However, cervicovaginal fluid (CVF) and semen have significant H2O2-blocking activity.
  18. ncbi Sperm morphology, motility, and concentration in fertile and infertile men
    D S Guzick
    Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    N Engl J Med 345:1388-93. 2001
    Although semen analysis is routinely used to evaluate the male partner in infertile couples, sperm measurements that discriminate between fertile and infertile men are not well defined.
  19. ncbi Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells
    David J Sharkey
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide SA 5005, Australia
    Mol Hum Reprod 13:491-501. 2007
    Exposure to semen elicits an inflammatory response in the female reproductive tract of rodents and other animals. The nature and regulation of any similar response in humans is poorly understood...
  20. ncbi Effects of radiofrequency electromagnetic waves (RF-EMW) from cellular phones on human ejaculated semen: an in vitro pilot study
    Ashok Agarwal
    Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Fertil Steril 92:1318-25. 2009
    To evaluate effects of cellular phone radiofrequency electromagnetic waves (RF-EMW) during talk mode on unprocessed (neat) ejaculated human semen.
  21. ncbi Proteomic analysis of seminal plasma from normal volunteers and post-vasectomy patients identifies over 2000 proteins and candidate biomarkers of the urogenital system
    Ihor Batruch
    Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    J Proteome Res 10:941-53. 2011
    ..These proteins may serve as candidate biomarkers for future studies of infertility and urogenital diseases...
  22. ncbi Persistent HIV RNA shedding in semen despite effective antiretroviral therapy
    Prameet M Sheth
    Department of Medicine, Dalla Lana School of Public Health, Toronto, Ontario, Canada
    AIDS 23:2050-4. 2009
    ..A prospective study of men starting ART (n = 25) demonstrated rapid, substantial reductions in semen HIV RNA...
  23. ncbi A novel application of cell-free seminal mRNA: non-invasive identification of the presence of germ cells or complete obstruction in men with azoospermia
    Honggang Li
    Family Planning Research Institute Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Hum Reprod 27:991-7. 2012
    ..This study applied cfs-mRNA in identifying the presence of either germ cells or complete obstruction in men with azoospermia...
  24. pmc Human immunodeficiency virus infects human seminal vesicles in vitro and in vivo
    Claire Deléage
    Institut National de la Sante et de la Recherche Medicale, Unite 625, Institut Federatif de Recherche 140, Rennes, France
    Am J Pathol 179:2397-408. 2011
    b>Semen represents the main vector of HIV dissemination worldwide, yet the origin of HIV in semen remains unclear...
  25. ncbi Detection of viral genomes of caprine arthritis-encephalitis virus (CAEV) in semen and in genital tract tissues of male goat
    M Z Ali Al Ahmad
    Department of Research into the Health Risk and Biotechnology of Reproduction ENVN, BP 40706, Nantes Cedex 03, France
    Theriogenology 69:473-80. 2008
    The aim of this study was to determine the infectious status of semen and genital tract tissues from male goat naturally infected with the caprine lentivirus...
  26. pmc TRY-5 is a sperm-activating protease in Caenorhabditis elegans seminal fluid
    Joseph R Smith
    Department of Human Genetics, University of Utah, Salt Lake City, Utah, USA
    PLoS Genet 7:e1002375. 2011
    ..Our results provide insight into how C. elegans has adopted sex-specific regulation of sperm motility to accommodate its male-hermaphrodite mode of reproduction...
  27. ncbi Influence of genital heat stress on semen quality in humans
    A Jung
    Center of Dermatology and Andrology, Justus Liebig University, Giessen, Germany
    Andrologia 39:203-15. 2007
    ..positively correlates with daytime scrotal temperatures and daytime scrotal temperature negatively correlates with semen quality...
  28. ncbi Evidence of shared Epstein-Barr viral isolates between sexual partners, and low level EBV in genital secretions
    Ranjit Thomas
    Clinical and Basic Virology Laboratory, School of Biomedical Sciences, University of Edinburgh, Summerhall, Edinburgh, United Kingdom
    J Med Virol 78:1204-9. 2006
    ..0012). Female cervical (n = 84), male urethral (n = 55), and semen (n = 30) samples from asymptomatic, unselected volunteers were analyzed for the presence of EBV DNA, revealing 7%, ..
  29. pmc Identification of ejaculated proteins in the house mouse (Mus domesticus) via isotopic labeling
    Matthew D Dean
    Molecular and Computational Biology, University of Southern California, 1050 Childs Way, Los Angeles, CA, USA
    BMC Genomics 12:306. 2011
    ..In addition to gaining insights into possible functions and fates of ejaculated proteins, our study serves as proof of concept that isotopic labeling is a powerful means to study reproductive proteins...
  30. ncbi A review of the physical and chemical properties of human semen and the formulation of a semen simulant
    Derek H Owen
    Department of Biomedical Engineering, Duke University, Box 90281, Durham, NC 27708, USA
    J Androl 26:459-69. 2005
    A fluid medium was developed to simulate the salient physical and chemical properties of human semen. The composition of the medium was based upon an extensive review of the literature on constituents of human semen...
  31. ncbi Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study
    Aleksander Giwercman
    Reproductive Medicine Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Int J Androl 33:e221-7. 2010
    ..b>Semen analysis was performed as recommended by the WHO. DFI was assessed using SCSA...
  32. ncbi Role of semen in HIV-1 transmission: inhibitor or facilitator?
    Gustavo F Doncel
    CONRAD Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Am J Reprod Immunol 65:292-301. 2011
    ..transmission, the virus is typically deposited in the vagina as cell-free and cell-associated virions carried by semen. But semen is more than just a carrier for HIV-1...
  33. ncbi Glutathione and free sulphydryl content of seminal plasma in healthy medical students during and after exam stress
    S Eskiocak
    Department of Biochemistry, Trakya University, School of Medicine, Edirne, Turkey
    Hum Reprod 20:2595-600. 2005
    It has been reported that there is a relationship between stress and infertility. The mechanisms of stress-related semen quality alterations have not been fully elucidated...
  34. ncbi Semen quality and male reproductive health: the controversy about human sperm concentration decline
    P Jouannet
    Laboratoire de Biologie de la Reproduction, GREFH, CECOS, Hĵpital Cochin, Universite Paris V, France
    APMIS 109:333-44. 2001
    ..These studies should not be limited to the analysis of sperm concentration, as this may not be the best biomarker of testis function and human fertility...
  35. ncbi Relationships between sperm motility characteristics assessed by the computer-aided sperm analysis (CASA) and fertilization rates in vitro
    Y Hirano
    Department of Obstetrics and Gynecology, Jichi Medical School, 3311 1, Yakushiji, Minamikawachi Machi, Tochigi 329 0498, Japan
    J Assist Reprod Genet 18:213-8. 2001
    ..This study was carried out to investigate the relationships between the CASA estimates and fertilization rates in vitro...
  36. ncbi Lipid peroxidation and antioxidant enzyme activities in infertile men: correlation with semen parameter
    Fatma Ben Abdallah
    Human Pathologies and Oxidative Stress Unit, Superior Institute of Biotechnology of Sfax, Sfax, Tunisia
    J Clin Lab Anal 23:99-104. 2009
    ..of this study was to investigate the oxidative stress status and antioxidant enzyme activities in infertile men's semen and to determine their relationship with spermatozoa characteristics...
  37. ncbi The use of semen parameters to identify the subfertile male in the general population
    F H van der Merwe
    Reproductive Biology Unit, Department of Obstetrics and Gynecology, University of Stellenbosch and Tygerberg Hospital, Tygerberg, South Africa
    Gynecol Obstet Invest 59:86-91. 2005
    To present a structured review of the literature published on semen parameters and in vivo fertility potential and to establish fertility/subfertility thresholds for sperm morphology using Tygerberg strict criteria, sperm concentration, ..
  38. ncbi Detection of swine Torque teno virus genogroups 1 and 2 in boar sera and semen
    T Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Theriogenology 68:966-71. 2007
    ..In the present study, the prevalence of two distinct swine TTV genogroups in boar semen and sera was determined by a nested PCR method...
  39. ncbi The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis
    A A Macdonald
    School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1142, New Zealand
    Hum Reprod Update 16:293-311. 2010
    It has been suggested that body mass index (BMI), especially obesity, is associated with subfertility in men. Semen parameters are central to male fertility and reproductive hormones also play a role in spermatogenesis...
  40. ncbi Bacteriolytic activity in the ejaculate of an insect
    Oliver Otti
    Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Am Nat 174:292-5. 2009
    ....
  41. ncbi Human papillomavirus prevalence and type distribution in male anogenital sites and semen
    Carrie M Nielson
    Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health, Tucson, Arizona, USA
    Cancer Epidemiol Biomarkers Prev 16:1107-14. 2007
    ..Specifically, the prevalence of type-specific HPV infection and the distribution of infections by anogenital anatomic site in men are incompletely characterized...
  42. pmc Drosophila female sexual behavior induced by sterile males showing copulation complementation
    L Xue
    Institute for Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 97:3272-5. 2000
    ..Our observations may have important implications for the role of sexual behavior in evolution and for the treatment of male sexual dysfunction in humans...
  43. ncbi Detection of herpes simplex virus, cytomegalovirus, and Epstein-Barr virus in the semen of men attending an infertility clinic
    Nikiforos Kapranos
    Division of Molecular Pathology, Department of Pathology, Amalia Fleming Hospital, Athens, Greece
    Fertil Steril 79:1566-70. 2003
    To investigate the prevalence of herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) in the semen of men with fertility problems.
  44. pmc Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic
    Jorge E Chavarro
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Fertil Steril 93:2222-31. 2010
    ..To examine the association between body weight and measures of male reproductive potential...
  45. pmc Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice
    Sarah A Robertson
    Research Centre for Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 80:1036-45. 2009
    ..Both seminal plasma and sperm components of the seminal fluid are necessary to confer full tolerance and elicit the Treg cell response, potentially through provision of immune-deviating cytokines and antigens, respectively...
  46. pmc Cationic polypeptides contribute to the anti-HIV-1 activity of human seminal plasma
    Julie A Martellini
    Department of Molecular Biology and Microbiology, Biomolecular Science Center, Burnett School of Biomedical Sciences at University of Central Florida, Orlando, Florida, USA
    FASEB J 23:3609-18. 2009
    ..Collectively, these results indicate that the cationic polypeptide fraction of SP is active against HIV-1, and that semenogelin-derived peptides contribute to the intrinsic anti-HIV-1 activity of SP...
  47. pmc House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Environ Health Perspect 118:318-23. 2010
    ..Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects...
  48. pmc Sex peptide is required for the efficient release of stored sperm in mated Drosophila females
    Frank W Avila
    Department of Biology, Gustavus Adolphus College, St Peter, MN 56082, USA
    Genetics 186:595-600. 2010
    ..Our findings illustrate a direct role for SP in the release of sperm from storage...
  49. ncbi Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma
    Anne Genevieve Marcelin
    UPMC Univ Paris 06, EA 2387, Paris, France
    AIDS 22:1677-9. 2008
    ..HIV-1 infected men enrolled in an assisted reproductive technology (ART) program harbored detectable HIV-1 RNA in semen, although they had no other sexually transmitted disease and their blood viral load was undetectable for at least ..
  50. pmc Battle and ballet: molecular interactions between the sexes in Drosophila
    Mariana F Wolfner
    Department of Molecular Biology and Genetics, 423 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    J Hered 100:399-410. 2009
    ..Over evolutionary time this disconnect can, in theory, precipitate a "battle" between the sexes, potentially leading to the rapid sequence changes that have been observed for some seminal proteins across species...
  51. ncbi Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Research Group
    M S Cohen
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7030, USA
    Lancet 349:1868-73. 1997
    ..We investigated the hypothesis that STDs increase the likelihood of transmission of HIV-1 through increased concentration of the virus in semen.
  52. pmc Adverse trends in male reproductive health: we may have reached a crucial 'tipping point'
    A M Andersson
    Int J Androl 31:74-80. 2008
    ..However, several studies suggest that semen samples where the concentration of sperms is below 40 mill/mL may be associated with longer time to pregnancy or ..
  53. ncbi Reactive oxygen species as an independent marker of male factor infertility
    Ashok Agarwal
    Center for Advanced Research in Human Reproduction, Infertility and Sexual Function, Glickman Urological Institute and Department of Obstetrics Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Fertil Steril 86:878-85. 2006
    ..To determine the abnormal patterns of reactive oxygen species (ROS) production in male factor infertility (MFI) patients and to define the ROS reference values in such patients...
  54. ncbi Transforming growth factor beta--a mediator of immune deviation in seminal plasma
    Sarah A Robertson
    Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, Adelaide University, South Australia, Australia
    J Reprod Immunol 57:109-28. 2002
    ..The seminal vesicle gland is the principal source of TGFbeta in the semen of mice, where its synthesis is regulated by testosterone...
  55. ncbi Human immunodeficiency virus viral load in blood plasma and semen: review and implications of empirical findings
    Seth C Kalichman
    Department of Psychology, University of Connecticut, Storrs, Connecticut 06269, USA
    Sex Transm Dis 35:55-60. 2008
    ..sexual HIV infectiousness from blood viral load hinges on the association between HIV in blood plasma (BPVL) and semen viral load (SVL)...
  56. ncbi Proteomic analysis of heparin-binding proteins from human seminal plasma: a step towards identification of molecular markers of male fertility
    Vijay Kumar
    Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110 029, India
    J Biosci 34:899-908. 2009
    ..This information on HBPs would be useful for identifying potential biomarkers of fertility in the near future...
  57. ncbi Cytomegalovirus DNA in semen of men seeking fertility evaluation in Abidjan, Côte d'Ivoire
    F Diafouka
    Laboratoire de Biochimie et Biologie de la Reproduction Humaine, UFR des Sciences Pharmaceutiques et Biologiques, Abidjan, Cote d Ivoire
    Eur J Clin Microbiol Infect Dis 26:295-6. 2007
  58. ncbi Oxidative stress and male infertility: from research bench to clinical practice
    Ramadan A Saleh
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Urological Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Androl 23:737-52. 2002
  59. ncbi Genetic parameter estimates for scrotal circumference and semen characteristics of Line 1 Hereford bulls
    C G Kealey
    Montana State University, Bozeman, 59717, USA
    J Anim Sci 84:283-90. 2006
    The objectives of this study were to estimate heritability for scrotal circumference (SC) and semen traits and their genetic correlations (rg) with birth weight (BRW)...
  60. ncbi Detection of bovine herpesvirus 1 and 5 in semen from Brazilian bulls
    M T Oliveira
    Virology Laboratory, Microbiology Department, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul UFRGS, Porto Alegre, CEP 90050 170, Rio Grande do Sul RS, Brazil
    Theriogenology 75:1139-45. 2011
    ..In the present study, BoHV-1 and/or BoHV-5 DNA were detected in bovine semen samples from two states of Brazil by two species-specific nested polymerase chain reactions (nPCRs)...
  61. ncbi Increase of oxidative stress in human sperm with lower motility
    Shu Huei Kao
    School of Medical Laboratory Science and Biotechnology, Taipei Medical University, Taipei, Taiwan
    Fertil Steril 89:1183-90. 2008
    ..To investigate the causal role of oxidative-stress status on human sperm motility...
  62. ncbi Effect of chronic alcoholism on male fertility hormones and semen quality
    K R Muthusami
    The Tamil Nadu Dr M G R Medical University, Chennai, India
    Fertil Steril 84:919-24. 2005
    To evaluate the effects of chronic alcoholism on the male fertility hormones and quality of semen.
  63. ncbi Effect of cryopreservation on sperm DNA integrity in patients with teratospermia
    Guruprasad Kalthur
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal, India
    Fertil Steril 89:1723-7. 2008
    ..To test whether sperm with abnormal head morphology are more likely to undergo DNA damage and/or chromatin modification during the process of freeze-thawing...
  64. ncbi [Zinc content analysis in serum, seminal plasma and spermatozoa of asthenozoospermic and oligoasthenozoospermic patients]
    Rong Po Zhao
    Research Institute of Family Planning, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Zhonghua Nan Ke Xue 11:680-2. 2005
    ..To detect the zinc content in serum, seminal plasma and spermatozoa of asthenozoospermic and oligoasthenozoospermic patients, and analyse the relationship between zinc changes and sperm density as well as sperm motility...
  65. ncbi Prevalence of asymptomatic inflammatory (National Institutes of Health Category IV) prostatitis in young men according to semen analysis
    Paul Korrovits
    Andrology Center, Tartu University Hospital, Tartu, Estonia
    Urology 71:1010-5. 2008
    ..To determine the prevalence of asymptomatic inflammatory (National Institutes of Health category IV) prostatitis in a cross-sectional community sample of young men...
  66. ncbi Seminal plasma proteins: what role do they play?
    Heriberto Rodriguez-Martinez
    Department of Clinical and Experimental Medicine IKE, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Am J Reprod Immunol 66:11-22. 2011
    b>Semen is a heterogeneous and complex cell suspension in a protein-rich fluid with different functions, some of them well known, others still obscure.
  67. pmc Semen of HIV-1-infected individuals: local shedding of herpesviruses and reprogrammed cytokine network
    Andrea Lisco
    Section of Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 205:97-105. 2012
    b>Semen is the main carrier of sexually transmitted viruses, including human immunodeficiency virus type 1 (HIV-1)...
  68. ncbi The transport of chemicals in semen
    Leah Klemmt
    College of William and Mary, Williamsburg, Virginia, USA
    Birth Defects Res B Dev Reprod Toxicol 74:119-31. 2005
    Three mechanisms have been proposed for exposure of the conceptus to chemicals in semen: access of chemicals to the maternal circulation after absorption from the vagina, direct chemical exposure of the conceptus following transport from ..
  69. pmc Multicenter comparison of PCR assays for detection of human herpesvirus 8 DNA in semen
    P E Pellett
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 37:1298-301. 1999
    Reported prevalences of human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus) in semen have ranged widely...
  70. ncbi Relationship among standard semen parameters, glutathione peroxidase/glutathione reductase activity, and mRNA expression and reduced glutathione content in ejaculated spermatozoa from fertile and infertile men
    Nicolas Garrido
    Instituto Valenciano de Infertilidad Valencia, Andrology Laboratory and Semen Bank, Valencia, Spain
    Fertil Steril 82:1059-66. 2004
    ..To determine the expression and enzymatic activity of glutathione peroxidase (GPX)-1, GPX-4, and glutathione reductase together with glutathione (GSH) concentrations in spermatozoa from fertile and infertile men...
  71. ncbi The role of semen in sexual transmission of HIV: beyond a carrier for virus particles
    Juan Sabatte
    Centro Nacional de Referencia para el SIDA, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Microbes Infect 13:977-82. 2011
    ..couples is by far the most frequent mode of HIV-1 (human immunodeficiency virus type 1) transmission being semen the main vector for HIV-1 dissemination worldwide...
  72. ncbi Altered levels of seminal nitric oxide, nitric oxide synthase, and enzymatic antioxidants and their association with sperm function in infertile subjects
    T Ramya
    Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, New Delhi, India
    Fertil Steril 95:135-40. 2011
    ..To investigate the association between specific reactive nitrogen species and sperm function among infertile subjects...
  73. ncbi Associations between andrological measures, hormones and semen quality in fertile Australian men: inverse relationship between obesity and sperm output
    T M Stewart
    Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne IVF Reproductive Services, The Royal Women s Hospital, Melbourne, Australia
    Hum Reprod 24:1561-8. 2009
    ..TTP) study (number of menstrual cycles taken to conceive) to determine whether the average TTP is increasing and semen quality decreasing with time...
  74. pmc Semen may harbor HIV despite effective HAART: another piece in the puzzle
    Philippe Halfon
    Department of Virology, Laboratoire Alphabio, Marseille, France
    PLoS ONE 5:e10569. 2010
    The risk of male-to-female intravaginal HIV-1 transmission is estimated at about 1 event per 200-2000 coital acts. The aim of this study was to assess the residual risk of HIV presence in semen in patients under HAART therapy.
  75. ncbi The association between semen quality in workers and the concentration of di(2-ethylhexyl) phthalate in polyvinyl chloride pellet plant air
    Li Ping Huang
    Department of Safety, Health and Environmental Engineering, National Kaohsiung First University of Science and Technology, Kaohsiung, Taiwan
    Fertil Steril 96:90-4. 2011
    To investigate potential associations between semen quality in workers and the concentrations of di(2-ethylhexyl) phthalate (DEHP) in personal air collected from polyvinyl chloride (PVC) plants.
  76. ncbi Prevalence of human herpes virus types 1-7 in the semen of men attending an infertility clinic and correlation with semen parameters
    Eirini Neofytou
    Laboratory of Human Reproduction, IVF Clinic, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Crete, Crete, Greece
    Fertil Steril 91:2487-94. 2009
    To determine the prevalence of herpes viruses in the semen of an asymptomatic male cohort with and without infertility problems and its association with altered semen parameters.
  77. ncbi Prenatal and adult exposures to smoking are associated with adverse effects on reproductive hormones, semen quality, final height and body mass index
    Trine L Ravnborg
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Hum Reprod 26:1000-11. 2011
    Exposure to tobacco smoking prenatally is a risk factor for reduced semen quality, but whether the exposure has adverse effects on reproductive hormones, pubertal development or adult BMI remain largely unexplored...
  78. pmc Detection of U.S., Lelystad, and European-like porcine reproductive and respiratory syndrome viruses and relative quantitation in boar semen and serum samples by real-time PCR
    A Wasilk
    Department of Veterinary Science, South Dakota State University, Brookings, South Dakota 57007 1396, USA
    J Clin Microbiol 42:4453-61. 2004
    Transmission of porcine reproductive and respiratory syndrome virus (PRRSV) via boar semen has been documented...
  79. ncbi Herpes virus infected spermatozoa following density gradient centrifugation for IVF purposes
    V Michou
    Locus Medicus SA, Ampelokipi, Athens, Greece
    Andrologia 44:174-80. 2012
    Studies have documented the presence of herpes viruses in semen. The aim of our study was to determine whether they persist in semen samples following two-density gradient centrifugation for IVF purposes...
  80. pmc Genital tract sequestration of SIV following acute infection
    James B Whitney
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    PLoS Pathog 7:e1001293. 2011
    ..the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection...
  81. ncbi Seminal reactive oxygen species as predictors of fertilization, embryo quality and pregnancy rates after conventional in vitro fertilization and intracytoplasmic sperm injection
    Branko Zorn
    Andrology Centre, Department of Obstetrics and Gynecology, Medical Centre Ljubljana, Slovenia
    Int J Androl 26:279-85. 2003
    High seminal reactive oxygen species (ROS) are related to poor semen quality and impaired fertilization...
  82. ncbi Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality
    Jiri Rubes
    Department of Genetics and Reproduction, Veterinary Research Institute, Brno, Czech Republic
    Hum Reprod 20:2776-83. 2005
    This study examined potential associations between exposure to episodes of air pollution and alterations in semen quality...
  83. ncbi Proteomic approach in the identification of fertility pattern in seminal plasma of fertile men
    Domenico Milardi
    International Scientific Institute Paolo VI, Universita Cattolica del S Cuore, Rome, Italy
    Fertil Steril 97:67-73.e1. 2012
    ..To identify a panel of common seminal proteins in human seminal plasma by fertile men that might be involved in successful reproduction...
  84. ncbi Discordance in HIV-1 viral loads and antiretroviral drug concentrations comparing semen and blood plasma
    G Lorello
    Faculty of Medicine, University of Ottawa, Ottawa, Canada
    HIV Med 10:548-54. 2009
    ..Therefore, we wanted to correlate HIV viral loads and drug concentrations in semen plasma (SP) and BP.
  85. ncbi [Peroxidation components of sperm lipid membranes in male infertility]
    M Fraczek

    Ginekol Pol 72:73-9. 2001
    ..b>Semen samples were obtained from healthy volunteers and infertile males...
  86. ncbi Selenium status of idiopathic infertile Nigerian males
    Oluyemi Akinloye
    Department of Chemical Pathology, College of Health Sciences, Ladoke Akintola University of Technology, Oyo State, Nigeria
    Biol Trace Elem Res 104:9-18. 2005
    ..A disturbance in this balance has a significant influence on spermatogenesis. Selenium appears to have a positive influence on Leydig cells, thus influencing the secretion of testosterone...
  87. ncbi Glutathione and glutathione S-transferases A1-1 and P1-1 in seminal plasma may play a role in protecting against oxidative damage to spermatozoa
    Maarten T M Raijmakers
    Department of Gastroenterology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Fertil Steril 79:169-72. 2003
    ..To study the levels of glutathione, glutathione S-transferase A1-1, and glutathione S-transferase P1-1 in seminal fluid of fertile and subfertile men...
  88. ncbi Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men
    Abasalt Hosseinzadeh Colagar
    Department of Biology, Faculty of Basic Science, University of Mazandaran, Babolsar 47416 95447, Iran
    Nutr Res 29:82-8. 2009
    ..b>Semen samples were provided by fertile (smoker [n = 17], nonsmoker [n = 19]) and infertile men (smoker [n = 15], ..
  89. ncbi Relationship between seminal ascorbic acid and sperm DNA integrity in infertile men
    Gyun Jee Song
    Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Androl 29:569-75. 2006
    ..Abnormal sperm DNA integrity (DFI >or= 30%) was observed in 12% of the patients with normal semen parameters and in 52% of the patients with abnormal semen parameters...
  90. ncbi Antioxidant intake is associated with semen quality in healthy men
    B Eskenazi
    140 Earl Warren Hall, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Hum Reprod 20:1006-12. 2005
    We seek to determine whether dietary and supplement intake of specific micronutrients (zinc and folate) and antioxidants (vitamins C, E and beta-carotene) is associated with semen quality.
  91. ncbi Does the number and size of veins ligated at left-sided microsurgical subinguinal varicocelectomy affect semen analysis outcomes?
    Alan W Shindel
    Division of Urology, Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Urology 69:1176-80. 2007
    To determine whether the preoperative and intraoperative findings at unilateral microsurgical subinguinal varicocelectomy are predictive of semen analysis changes postoperatively.
  92. ncbi Brief but efficient: acute HIV infection and the sexual transmission of HIV
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Infect Dis 189:1785-92. 2004
    ..We examined whether viral dynamics in the genital tract during the natural history of acute human immunodeficiency virus type 1 (HIV-1) infection could explain efficient heterosexual transmission of HIV...
  93. pmc Identification, RNAi knockdown, and functional analysis of an ejaculate protein that mediates a postmating, prezygotic phenotype in a cricket
    Jeremy L Marshall
    Department of Entomology, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 4:e7537. 2009
    ..These findings represent one of the first studies to identify a protein that plays a role in mediating both a postmating, prezygotic isolation pathway and reproductive senescence...
  94. ncbi Involvement of semenogelin-derived peptides in the antibacterial activity of human seminal plasma
    Frédéric Bourgeon
    GERM INSERM U 435, Campus de Beaulieu, Universite de Rennes I, 35042 Rennes Cedex, Bretagne, France
    Biol Reprod 70:768-74. 2004
    ..known potent microbicidal activity--phospholipase A2, lactoferrin, and lysozyme--we also found that peptides produced by cleavage of semenogelin I, the predominant human semen coagulum protein, had high levels of antibacterial activity.
  95. pmc Predicted seminal astacin-like protease is required for processing of reproductive proteins in Drosophila melanogaster
    Kristipati Ravi Ram
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 103:18674-9. 2006
    ....
  96. ncbi Evaluation and assessment of semen for IVF/ICSI
    D Y Liu
    University of Melbourne, Department of Obstetrics and Gynaecology, Royal Women s Hospital, Carlton, Victoria, Australia
    Asian J Androl 4:281-5. 2002
    Evaluation and assessment of semen is very important for both diagnosis of male infertility and selection of patients for treatment with IVF or ICSI...
  97. pmc Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI
    Kyeong Ae Kim
    Institute of Molecular Virology, University Hospital Ulm, 89081 Ulm, Germany
    Retrovirology 7:55. 2010
    HIV-1 is usually transmitted in the presence of semen. We have shown that semen boosts HIV-1 infection and contains fragments of prostatic acid phosphatase (PAP) forming amyloid aggregates termed SEVI (semen-derived enhancer of viral ..
  98. ncbi Sperm death and dumping in Drosophila
    Rhonda R Snook
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK
    Nature 428:939-41. 2004
    ..Instead, males may cause stored sperm to be dumped or females may differentially eject sperm from the previous mating...
  99. ncbi Novel antimicrobial peptide of human epididymal duct origin
    Hans Henning von Horsten
    IHF Institute for Hormone and Fertility Research at the University of Hamburg, D 22529 Hamburg, Germany
    Biol Reprod 67:804-13. 2002
    ....
  100. pmc Semen protects CD4+ target cells from HIV infection but promotes the preferential transmission of R5 tropic HIV
    Emmanuel Balandya
    Program in Experimental and Molecular Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Immunol 185:7596-604. 2010
    Sexual intercourse is the major means of HIV transmission, yet the impact of semen on HIV infection of CD4(+) T cells remains unclear...
  101. pmc The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection
    Ilona Hauber
    Heinrich Pette Institute for Experimental Virology and Immunology, Martinistrasse 52, D 20251 Hamburg, Germany
    Proc Natl Acad Sci U S A 106:9033-8. 2009
    Peptide fragments, derived from prostatic acidic phosphatase, are secreted in large amounts into human semen and form amyloid fibrils...

Research Grants73

  1. US STUDY OF SEMEN QUALITY IN PARTNERS OF PREGNANT WOMEN
    Shanna Swan; Fiscal Year: 2001
    ..environmental exposures and decreased male reproductive function, including a reported world-wide decline in semen quality over the past fifty years. Considerable geographic variability in sperm density has also been reported...
  2. ORGANOPHOSPHATE PESTICIDES AND HUMAN REPRODUCTIVE HEALTH
    Xiping Xu; Fiscal Year: 2003
    ..Reproductive endpoints will include (1) semen parameters (concentration, total count, motility, progression and morphology), (2) menstrual disorders (..
  3. Regulation of insulins by the Rhox5 homeobox gene supports spermatogenesis
    James Maclean; Fiscal Year: 2009
    ..Untreatable subfertility caused by poor semen quality accounts for 75% of patients consulting for fertility problems Project Narrative Untreatable subfertility ..
  4. Validation of Novel Infertility Biomarker
    PETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012
    ..Current methods of human semen analysis and diagnostics of human male infertility rely heavily on subjective light microscopic evaluation...
  5. AGE-RELATED ALTERATION OF LEYDIG CELL REDOX ENVIRONMENT A RISK FACTOR FOR SUSCEPT
    Kassim Traore; Fiscal Year: 2013
    ..endocrine disruptor, can lead to reproductive health issues including hypospadias, testicular cancer, and poor semen quality. During development, androgen plays a critical role in programming sex organ morphogenesis and function...
  6. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..inhibin- B, MIS, LH, FSH, IGF-1, IGF-BP3, TSH and free T4);4) altered adult testis function, specifically semen quality and hormonal markers of mature testis function and the reproductive axis (testosterone, inhibin-B, LH and ..
  7. Drug Transport at the Blood-Testis Barrier
    Nathan J Cherrington; Fiscal Year: 2013
    ..transporters as a means of circumventing the BTB since a number of NSAs are capable of accumulating in the semen of treated men...
  8. Response of Rhesus Sperm to Freezing: Recovery from Osmotic and Oxidative Stress
    Stuart A Meyers; Fiscal Year: 2010
    ..b>Semen donors are often selected based on successful cryopreservation results, however, many individual males, including ..
  9. Paternal Environmental Exposures and Reproductive Outcomes: A Comparison of in Vi
    DEBORAH ANN HANSEN; Fiscal Year: 2013
    ..Multiple mechanisms of action are implicated in male mediated adverse reproductive events to include: a) toxins in semen that can result in vaginal absorption and in exposure of the embryo post conception, and b) deleterious effects ..
  10. Environmental Endocrine Disruptors and Human Sperm Chromosomal Abnormalities
    Melissa Perry; Fiscal Year: 2012
    ..Archived semen, serum, and urine samples are available from 500 men who have attended a large hospital based fertility clinic for ..
  11. Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes
    Russ B Hauser; Fiscal Year: 2013
    ..In experimental studies, phthalates alter male reproductive tract development, decrease semen quality, and induce anovulatory infertility and pregnancy loss...
  12. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..an important public-health issue during recent decades: The incidence of testicular cancer has increased and semen quality has decreased, and the incidences of cryptorchidism and hypospadias appear to have increased in certain ..
  13. Phase 2 Study of rAAV1-CB-hAAT for Treatment of Alpha-1 Antitrypsin Deficiency
    Jeffrey D Chulay; Fiscal Year: 2013
    ..Additional information to be collected will include presence of the vector in blood or semen, changes in serum anti-AAV antibody titers, and changes in T cell responses to AAV and AAT...
  14. Validation of Biomarkers to Distinguish Aggressive from Indolent Prostate Cancer
    George Wilding; Fiscal Year: 2013
    ..Aims #1 and #2 with patient outcome to validate the SSAT expression and the ac-spd and/or the ac-spm level in the semen, blood or urine samples of PCa patients...
  15. DETERMINANTS OF MALE AND FEMALE FECUNDITY AND FERTILITY-DATA COORDINATING CENTER
    Edward Clark; Fiscal Year: 2009
    ..Male partners provided semen samples for an objective assessment of male fecundity...
  16. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne A Marasco; Fiscal Year: 2010
    ..of AAV-GFP transduction, potential toxicities and effects of proinflammatory cytokines, hormonal conditions, semen and vaginal secretions on transduction efficiency and transgene persistence will be examined...
  17. Interferon Effects on HIV Transmission in Human Models
    Judy Lieberman; Fiscal Year: 2013
    ..Most sexual exposures do not lead to transmission. Of the swarms of virus in the semen, only a single virion is usually transmitted...
  18. Trichomonas vaginalis MIF: a role in prostate cancer and infertility?
    PATRICIA JEAN JOHNSON; Fiscal Year: 2013
    ..Increased level of human MIF (HuMIF) have been found in both prostate cancer and the semen of infertile men. We hypothesize that T...
  19. Device for Hyperfast Scalable Vitrification of Germplasm in Large Volumes
    IGOR KATKOV; Fiscal Year: 2013
    ..5-5 ?L). As such, cryopreservation of samples such as semen, cord blood stem cells, and sufficient amounts of pluripotent stem cells and ovarian tissue is extremely difficult...
  20. Peri-Conceptional Biomonitoring
    Christina Porucznik; Fiscal Year: 2013
    ..exposures during the earliest phases of human development, and 2) association of these exposures with semen quality and time to pregnancy in a community-dwelling cohort of 300 couples trying to conceive...
  21. Factors That Affect Endometrial Immunity: Implications for HIV Infection
    Joseph C Chen; Fiscal Year: 2012
    ..are to determine how commercially used spermicides, progestin-containing contraceptives and factors present in semen can increase the chances of Human Immunodeficiency Virus (HIV) infection...
  22. AMERICAN SOCIETY OF ANDROLOGY ANNUAL MEETING
    Dolores J Lamb; Fiscal Year: 2010
    ..Issues in Male Sexual Health: From Benchmark to Bedside" with a focus on physiology and treatment of sexual dysfunction, and a 1-day "hands- on" Andrology Lab Workshop on semen analysis with a focus on sperm motility evaluation.
  23. Alcohol Use and High Risk Behavior Among HIV-Positive Men
    SARAH WOOLF-KING; Fiscal Year: 2013
    ..e., last 24 hours) semen exposure that can be reliably recovered from self-administered vaginal swabs, (b) comparing these PSA tests to ..
  24. Polycyclic Aromatic Hydrocarbons And Male Reproductive Health
    HUEIWANG ANNA COOK JENG; Fiscal Year: 2010
    ..Baseline serum samples will be collected for genotype analysis of CYP1A1 and GSTM1 allelic variants. Semen will be collected to assess sperm quality and DNA integrity, and PAH-DNA adducts...
  25. Genetic Basis of Oligozoospermia in Infertile Males
    Alexander N Yatsenko; Fiscal Year: 2013
    ..An etiology of male infertility is often associated with abnormal semen characteristics (i.e., sperm concentration, motility, morphology, etc.)...
  26. Fertility Preservation in Prepubertal Boys: An Experimental Approach
    JILL PHILLIPS GINSBERG; Fiscal Year: 2010
    ..Prepubertal boys cannot produce semen by masturbation and they do not have mature sperm in their testes...
  27. Seminal HIV-1 Shedding and Drug Resistance in HIV-1/HSV-2 Coinfected Men on HAART
    Deborah Anderson; Fiscal Year: 2009
    ..Sexually transmitted infections (STIs) have been associated with elevated HIV-1 levels in semen, presumably due to promotion of HIV-1 replication in the genital tract by inflammatory cytokines which are ..
  28. Development of a Novel Semen-Activated Prodrug as an Anti-HIV Microbicide
    ROBERT WALTER BUCKHEIT; Fiscal Year: 2010
    ..delivery mechanism limits the tissue absorption of the SAMT until it comes in contact with the viral inoculum in semen by attaching it to a high molecular weight biocompatible polymer...
  29. COLORADO REPRODUCTIVE MEDICINE UNIT
    Ruben Alvero; Fiscal Year: 2013
    ..Observational studies have clearly demonstrated that obese men exhibit a compromise in reproductive hormones and semen parameters...
  30. Prenatal Organochlorine Exposure and Male Reproduction
    PAM R FACTOR LITVAK; Fiscal Year: 2010
    ..Disruption of male reproductive function, and in particular decreased semen quality, is thought to be associated with exposure to endocrine active chemicals...
  31. POTENTIATING AN HIV DNA VACCINE WITH FLAGELLIN AT THE CERVICAL/VAGINAL MUCOSA
    Dinesh Singh; Fiscal Year: 2011
    ..DNA along with a potent adjuvant will mount a strong immune response that will destroy HIV particles present in semen. Since flagellin also activates NK cells and dendritic cells non-specifically, we expected that it will help to ..
  32. Exposure To Polycyclic Aromatic Hydrocarbons And Male Sperm Quality
    HUEIWANG ANNA COOK JENG; Fiscal Year: 2010
    ..b>Semen will be collected to assess sperm quality, DNA adducts, and oxidative damage...
  33. Understanding genetics of spermatogenic failure by resequencing the sex chromosome
    RENEE GEORGE; Fiscal Year: 2013
    ..the sex chromosomes of men with nonobstructive azoospermia, a condition where no sperm is detected in their semen. The results of this research will enhance our understanding of human spermatogenesis and improve our ability to ..
  34. Epigenetic Defects in Human Spermatozoa: Biomarker of Infertility and Sperm Toxic
    REBECCA Z contact SOKOL; Fiscal Year: 2010
    ..intriguing in light of preliminary animal studies suggesting that toxic exposures that negatively affect semen parameters also alter sperm DNA methylation...
  35. Methods to determine HIV Transport and Inactivation by Microbicide coating Layers
    DAVID FRANK KATZ; Fiscal Year: 2010
    ..functioning of a microbicide product vaginal epithelial coating layer - to inhibit transport of HIV virions from semen to tissue and enable microbicide molecules to disable virus...
  36. Transmission-blocking vaccine for HIV-1
    Robert C Rose; Fiscal Year: 2010
    b>Semen contains cationic amyloid fibrils derived from proteolytic cleavage fragments of prostatic acid phosphatase (PAP) that efficiently capture HIV-1 particles...
  37. The Semen Enhancer of HIV Infection as a Novel Microbicide Target
    Stephen Dewhurst; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Human semen contains cationic amyloid fibrils, termed the "Semen Enhancer of Virus Infection" (SEVI), which strongly enhance HIV-1 infection and may play an important role in viral transmission...
  38. REPRODUCTIVE ASSESSMENTS BY CONTINUOIUS BREEDING (RACB)
    Rochelle Tyl; Fiscal Year: 2013
    ..Assessment by Continuous Breeding (RACB);multigenerational reproductive evaluation;Computer Assisted Semen Analyis (CASA);sperm count and motility;vaginal cytology;estrous cyclicity;endocrine disrupting chemicals;..
  39. REPRODUCTIVE ASSESSMENTS BY CONTINUOIUS BREEDING (RACB)
    Rochelle W Tyl; Fiscal Year: 2009
    ..Assessment by Continuous Breeding (RACB);multigenerational reproductive evaluation;Computer Assisted Semen Analyis (CASA);sperm count and motility;vaginal cytology;estrous cyclicity;endocrine disrupting chemicals;..
  40. H2-Gamendazole analogues as reversible non-hormonal male contraceptive agents
    Joseph S Tash; Fiscal Year: 2013
    ..Pilot proof-of-concept studies in non-human primates showed completely reversible declines in spermatid count and semen sperm count with no adverse side effects...
  41. Exploring HIV-Host Interactions in the Female Reproductive Tract
    Karen K Smith-McCune; Fiscal Year: 2013
    ..tract represents a highly permissive but understudied portal for HIV infection, 2) specific viral (Env) and host (semen peptides) factors importantly influence the success of male-to-female HIV transmission, 3) changes in sex hormone ..
  42. Factors Influencing Oral Transmission of SIV
    Donald L Sodora; Fiscal Year: 2010
    ..through ingesting the virus during breast-feeding;as well as in adults during oral genital transmission (virus in semen)...
  43. Crossover Study on Human Exposure to Phthalates and Male Fertility
    Russ B Hauser; Fiscal Year: 2013
    ..and reproductive health, we found a suggestive association between exposure to dibutyl phthalate (DBP) and reduced semen quality...
  44. Referral Center-Animal models of human genetic disease
    Mark E Haskins; Fiscal Year: 2013
    ..will be made available to other investigators for a nominal fee-for-service in the form of DNA, cells, frozen semen, and breeding stock...
  45. Novel Mucosal Models Predictive of Microbicide Safety
    Marla J Keller; Fiscal Year: 2012
    ..will be introduced in the presence of cervicovaginal secretions and challenged in vitro with virus introduced in semen. The migration of both cell-free and cell-associated HIV will be tested in the dual chamber model system...
  46. Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization
    Nadia R Roan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): HIV is most frequently transmitted following sexual contact, and semen is the vehicle fueling the global spread of this deadly virus...
  47. Microbicide Loaded Nanocarriers for Topical Delivery in HIV/AIDS Prevention
    BI BOTTI CELESTIN YOUAN; Fiscal Year: 2010
    ..be made of either bioadhesive (for longer topical duration of action), pH-sensitive (for a triggered release by semen either pH) or functionalized solid lipid matrix (for deeper penetration across the potential path of HIV virus) ..
  48. The role of envelope phosphatidylserine in the binding of HIV to target cells
    KOKI MORIZONO; Fiscal Year: 2012
    ..In fact, one research group found that amyloid fibrils in semen dramatically enhance HIV replication...
  49. Host Factors Influencing HIV Viral Load and Infectivity in Semen
    Christopher D Pilcher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Exposure to HIV-infected semen accounts for most viral transmissions worldwide, however the factors that determine the HIV viral load and infectivity of semen are not well understood...
  50. The Role of Exosomes in Semen for HIV Infection in the Genital Mucosa of Women
    Florian Hladik; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Exposure of the female genital tract to HIV-1-infected semen is the primary route of heterosexual HIV transmission...
  51. Origin of Seminal Virus in Human Immunodeficiency Virus Infection
    Martin D Hill; Fiscal Year: 2012
    ..Protease inhibitors and non-nucleoside reverse transcriptase inhibitors appear in semen at a fraction (typically, 2 - 15%) of their concentration in blood...
  52. The Role of Seminal Amyloid Fibrils in HIV-1 transmission on cervical mucosa
    ROSA AMELIA VELEZ; Fiscal Year: 2010
    ..HST transpires when semen (considered as the principal source for both cell-free (cf) and cell-associated (ca) virus) from an infected male ..
  53. The Semen Enhancer of HIV Infection as a Novel Microbicide Target
    Stephen Dewhurst; Fiscal Year: 2013
    PROJECT SUMMARY/ABSTRACT Human semen contains cationic amyloid fibrils, termed the "Semen Enhancer of Virus Infection" (SEVI), which strongly enhance HIV-1 infection and may play an important role in viral transmission...
  54. Pathogen trapping by genital mucus secretions
    JUSTIN S HANES; Fiscal Year: 2013
    ..which STD pathogens are usually transmitted: endocervical mucus, healthy cervicovaginal mucus, BV secretions, and semen. We will use multiple particle tracking and MPP to characterize the meshspacing and protective viscoelastic ..
  55. HIV IN SEMEN-EFFECTS OF STDS AND ANTIVIRAL THERAPY
    Myron S Cohen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): For the past 10 years we have focused on the biology of HIV in semen. Most recently we have used a novel HIV RNA detection strategy to identify people with acute HIV infection...
  56. Generating SEVI disaggregases to prevent HIV infection
    James Shorter; Fiscal Year: 2013
    ..the major route of HIV-1 infection and factors that promote this infectious route have recently been identified in semen. Fragments of prostatic acid phosphatase are a major component of semen and form amyloid fibrils that bind HIV ..
  57. HIV Testing and Treatment to Prevent Onward HIV Transmission among High-risk MSM
    Ann C Duerr; Fiscal Year: 2013
    ..established HIV infection to transmission among networked populations, such as MSM. HIV viral load (VL) in semen will be measured over a 6 month period in MSM with AHI and RHI who will be randomized to immediate or delayed ART...
  58. An In Vitro Model of Cell-Associated HIV-1 Transmission
    Deborah J Anderson; Fiscal Year: 2010
    ..adhesion molecule and chemokine receptor (CR) expression on CD4+ lymphocytes and macrophages isolated from semen of HIV-infected men, and immunohistochemistry and Bio-Plex/ELISA assays to characterize the expression of ..
  59. Next Generation Pre-exposure Prophylaxis
    J VICTOR GARCIA-MARTINEZ; Fiscal Year: 2013
    ..utilize cell free and cell associated primary transmitted/founder (F/T) viruses for challenge in the presence of semen;3) state-of-the-art analytical methods developed by Angela Kashuba at UNC to determine the PD/PK of vaginally ..
  60. Cervical/Vaginal Mucus and Microbicides
    Thomas Hope; Fiscal Year: 2013
    ..issue as previous clinical trials have indicated that microbicides do not function as expected in the presence of semen. Likewise, other factors, such as cervical/vaginal mucus, might also modulate microbicide function...
  61. Cervical/Vaginal Mucus and Microbicides
    Thomas Hope; Fiscal Year: 2012
    ..issue as previous clinical trials have indicated that microbicides do not function as expected in the presence of semen. Likewise, other factors, such as cervical/vaginal mucus, might also modulate microbicide function...
  62. BIOCHEMICAL MARKERS OF SPERM FERTILITY
    Gabor Huszar; Fiscal Year: 1999
    ..Develop sperm CK antibodies which will not react with seminal fluid CK, in order to directly measure sperm Ck in semen samples by immunotechnology already present in clinical laboratories and in doctors' offices...
  63. Regulation of the Reproductive Tract Environment and Prevention of HIV Infection
    CHARLES ROBERT WIRA; Fiscal Year: 2013
    ..3) Identify those factors (microbiome, STIs, semen, trauma) that are hormonally modulated in the FRT and may influence susceptibility to HIV infection...
  64. Seek and Treat for Optimal Outcomes and Prevention in HIV &AIDS in IDU
    JULIO SERGIO GONZALEZ MONTANER; Fiscal Year: 2013
    ..HAART has also been shown to decrease HIV levels in semen and vaginal secretions...
  65. ACCEPTABILITY AND SAFETY STUDY OF JANESWAY FEMALE CONDOM
    Ron Frezieres; Fiscal Year: 2000
    ..in perfecting female condoms that line the vagina and protect the female genital tract against exposure to semen and potentially infected genital secretions...
  66. PORTABILITY OF BIOCHEMICAL MARKERS OF SPERM MATURITY
    Gabor Huszar; Fiscal Year: 2001
    ..in line with the goals of the RFA, is the introduction of biochemical markers in addition to the conventional semen profile, in the monitoring of potential changes in sperm maturity, due to male reproductive toxicity...
  67. Serum Inhibin B Levels in Male Polymer Production Worker
    Richard Lewis; Fiscal Year: 2000
    Evaluation of potential exposure-related effects on male fertility is problematic. Semen samples are difficult to obtain in industrial surveillance programs and quality measures (sperm counts and motility) are highly variable within ..
  68. FUNDAMENTAL CRYOBIOLOGY OF HUMAN SPERMATOZOA
    John Critser; Fiscal Year: 1992
    Use of frozen human semen is now essential for artificial insemination by donor programs; as this permits the storage of semen until each donor is retested for the human immunosuppressive virus after sufficient time has elapsed for ..
  69. SEMEN AS A BIOMARKER OF EFFECT AMONG LEAD EXPOSED MEN
    Harvey Checkoway; Fiscal Year: 1993
    The overall objective of this project is to use semen quality as a biomarker of effect on the male reproductive system resulting from occupational and environmental exposures. Occupational exposure to lead will be the focus of this study...
  70. Soy Isoflavone Distribution in Biological Fluids as Markers of Prostate Exposure
    MINDY KURZER; Fiscal Year: 2007
    ..In addition, isoflavone levels in semen and post-massage urine will be determined and compared with EPS, in order to determine whether these fluids are ..
  71. EPIDEMIOLOGY, SEXUAL TRANSMISSION OF HHV8 IN MALAWI
    Evelyn Quinlivan; Fiscal Year: 2000
    ..unanswered questions the Investigator and her associates will analyze an existing, unique collection of blood and semen samples from Malawi...
  72. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne Marasco; Fiscal Year: 2009
    ..of AAV-GFP transduction, potential toxicities and effects of proinflammatory cytokines, hormonal conditions, semen and vaginal secretions on transduction efficiency and transgene persistence will be examined...
  73. MENSTRUAL FUNCTION AND PHYSICAL AND MENTAL JOB STRESS
    Maureen Hatch; Fiscal Year: 1993
    ..of menstrual function in order to identify and prevent work-related disorders among non-pregnant women (much as semen analysis has served to monitor male occupational exposures)...