bile

Summary

Summary: An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.

Top Publications

  1. pmc Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
    Liqing Yu
    McDermott Center for Human Growth and Development and Departments of Molecular Genetics and Biochemistry, The Howard Hughes Medical Institute and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:16237-42. 2002
  2. pmc Real-time PCR-based analysis of the human bile microRNAome identifies miR-9 as a potential diagnostic biomarker for biliary tract cancer
    Kengo Shigehara
    Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, Tokyo, Japan
    PLoS ONE 6:e23584. 2011
  3. pmc Bile acids as regulatory molecules
    Phillip B Hylemon
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0678, USA
    J Lipid Res 50:1509-20. 2009
  4. pmc Bile pigment pharmacokinetics and absorption in the rat: therapeutic potential for enteral administration
    A C Bulmer
    Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Southport, Queensland, Australia
    Br J Pharmacol 164:1857-70. 2011
  5. ncbi Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
    K F Kozarsky
    Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Nature 387:414-7. 1997
  6. ncbi Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease
    Raffaella M Gadaleta
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Biochim Biophys Acta 1801:683-92. 2010
  7. ncbi Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis
    Tim O Lankisch
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 53:875-84. 2011
  8. pmc Bile leakage after hepatic resection
    Y Yamashita
    Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Ann Surg 233:45-50. 2001
  9. pmc Bear bile: dilemma of traditional medicinal use and animal protection
    Yibin Feng
    School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, PR China
    J Ethnobiol Ethnomed 5:2. 2009
  10. pmc Biofilm formation and interaction with the surfaces of gallstones by Salmonella spp
    A M Prouty
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Infect Immun 70:2640-9. 2002

Detail Information

Publications307 found, 100 shown here

  1. pmc Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
    Liqing Yu
    McDermott Center for Human Growth and Development and Departments of Molecular Genetics and Biochemistry, The Howard Hughes Medical Institute and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:16237-42. 2002
    Cholesterol and other sterols exit the body primarily by secretion into bile. In patients with sitosterolemia, mutations in either of two ATP-binding cassette (ABC) half-transporters, ABCG5 or ABCG8, lead to reduced secretion of sterols ..
  2. pmc Real-time PCR-based analysis of the human bile microRNAome identifies miR-9 as a potential diagnostic biomarker for biliary tract cancer
    Kengo Shigehara
    Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, Tokyo, Japan
    PLoS ONE 6:e23584. 2011
    ..The aim of this study was to confirm the existence of miRNAs in human bile and to assess their potential as clinical biomarkers for BTC...
  3. pmc Bile acids as regulatory molecules
    Phillip B Hylemon
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0678, USA
    J Lipid Res 50:1509-20. 2009
    In the past, bile acids were considered to be just detergent molecules derived from cholesterol in the liver...
  4. pmc Bile pigment pharmacokinetics and absorption in the rat: therapeutic potential for enteral administration
    A C Bulmer
    Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Southport, Queensland, Australia
    Br J Pharmacol 164:1857-70. 2011
    ..Despite the therapeutic potential of bile pigments, little is known about their in vivo parenteral or enteral absorption after exogenous administration...
  5. ncbi Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
    K F Kozarsky
    Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Nature 387:414-7. 1997
    ..mediate these effects by increasing hepatic HDL cholesterol uptake or by increasing cholesterol secretion into bile, or both...
  6. ncbi Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease
    Raffaella M Gadaleta
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Biochim Biophys Acta 1801:683-92. 2010
    The nuclear receptor Farnesoid X Receptor (FXR) critically regulates nascent bile formation and bile acid enterohepatic circulation...
  7. ncbi Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis
    Tim O Lankisch
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 53:875-84. 2011
    ..We hypothesize that bile proteomic analysis distinguishes CC from nonmalignant lesions...
  8. pmc Bile leakage after hepatic resection
    Y Yamashita
    Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Ann Surg 233:45-50. 2001
    To identify the perioperative risk factors for postoperative bile leakage after hepatic resection, to evaluate the intraoperative bile leakage test as a preventive measure, and to propose a treatment strategy for postoperative bile ..
  9. pmc Bear bile: dilemma of traditional medicinal use and animal protection
    Yibin Feng
    School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, PR China
    J Ethnobiol Ethnomed 5:2. 2009
    Bear bile has been used in Traditional Chinese Medicine (TCM) for thousands of years...
  10. pmc Biofilm formation and interaction with the surfaces of gallstones by Salmonella spp
    A M Prouty
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Infect Immun 70:2640-9. 2002
    ..form biofilms on the surfaces of gallstones, where the bacteria are protected from high concentrations of bile and antibiotics...
  11. ncbi Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases
    Michael Trauner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Wien Med Wochenschr 158:542-8. 2008
    Alterations in bile secretion at the hepatocellular and cholangiocellular levels may cause cholestasis. Formation of 'toxic bile' may be the consequence of abnormal bile composition and can result in hepatocellular and/or bile duct injury...
  12. ncbi Transcriptional regulation of Salmonella enterica serovar Typhimurium genes by bile
    A M Prouty
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC 7758, San Antonio, TX 78229 3900, USA
    FEMS Immunol Med Microbiol 41:177-85. 2004
    DNA microarrays and two-dimensional (2-D) gel electrophoresis were utilized to analyze the global effect of bile on transcription and protein synthesis in Salmonella enterica serovar Typhimurium...
  13. ncbi Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Gastroenterology 114:755-63. 1998
    ..Because several Helicobacter sp. colonize the livers of animals and induce hepatitis, the aim of this study was to determine whether Helicobacter infection was associated with cholecystitis in humans...
  14. ncbi Efficacy and safety of fully covered self-expandable metallic stents in biliary complications after liver transplantation: a preliminary study
    Mario Traina
    Mediterranean Institute for Transplantation and Advanced Specialized Therapies University of Pittsburgh Medical Center, Palermo, Italy
    Liver Transpl 15:1493-8. 2009
    ..A cost analysis should be performed in order to evaluate whether to treat transplanted patients suffering from biliary complications with covered self-expandable metallic stent placement as first-line therapy...
  15. ncbi Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse
    David Q H Wang
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Physiol Gastrointest Liver Physiol 285:G494-502. 2003
    We explored the influence of the hydrophilic-hydrophobic balance of a series of natural bile acids on cholesterol absorption in the mouse. Male C57L/J mice were fed standard chow or chow supplemented with 0...
  16. ncbi Proteomic analysis of human bile from malignant biliary stenosis induced by pancreatic cancer
    Annarita Farina
    Biomedical Proteomics Research Group, Department of Bioinformatics and Structural Biology, Faculty of Medicine, Geneva University, Geneva CH 1211, Switzerland
    J Proteome Res 8:159-69. 2009
    Stenosis of the common bile duct may be either due to benign (chronic pancreatitis) or malignant (cholangiocarcinoma, pancreatic adenocarcinoma) conditions...
  17. pmc Rapid determination of reduced and oxidized glutathione levels using a new thiol-masking reagent and the enzymatic recycling method: application to the rat liver and bile samples
    Imam H Shaik
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, USA
    Anal Bioanal Chem 385:105-13. 2006
    ..plate assay for quantitation of reduced (GSH) and oxidized (GSSG) glutathione in the rat liver tissue and bile is described...
  18. ncbi Chemotactic response of Helicobacter pylori to human plasma and bile
    Mulugeta L Worku
    Department of Medical Microbiology, Imperial College School of Medicine at St Mary s, Norfolk Place, London W2 1NY, UK
    J Med Microbiol 53:807-11. 2004
    ..the role of chemotaxis in Helicobacter pylori colonization, the in vitro bacterium response to human plasma and bile (secretions containing chemoeffector compounds that are present in the gastric mucus layer) was examined...
  19. pmc Adaptation and preadaptation of Salmonella enterica to Bile
    Sara B Hernández
    Departamento de Genetica, Universidad de Sevilla, Sevilla, Spain
    PLoS Genet 8:e1002459. 2012
    b>Bile possesses antibacterial activity because bile salts disrupt membranes, denature proteins, and damage DNA. This study describes mechanisms employed by the bacterium Salmonella enterica to survive bile...
  20. ncbi A proteomic analysis of human bile
    Troels Zakarias Kristiansen
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Cell Proteomics 3:715-28. 2004
    We have carried out a comprehensive characterization of human bile to define the bile proteome...
  21. pmc Genetic characterization of the bile salt response in Lactobacillus plantarum and analysis of responsive promoters in vitro and in situ in the gastrointestinal tract
    Peter A Bron
    Wageningen Centre for Food Sciences, NIZO Food Research, P O Box 20, 6710 BA Ede, The Netherlands
    J Bacteriol 186:7829-35. 2004
    In this paper we describe the growth, morphological, and genetic responses of Lactobacillus plantarum WCFS1 to bile. Growth experiments revealed that a stepwise increase in the porcine bile concentration led to a gradual decrease in the ..
  22. ncbi Intraoperative indocyanine green fluorescent imaging for prevention of bile leakage after hepatic resection
    Masaki Kaibori
    Department of Surgery, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka 573 1191, Japan
    Surgery 150:91-8. 2011
    b>Bile leakage is a common complication of hepatectomy, and is associated with an increase in sepsis and liver failure. There are no standard preventive methods against bile leakage after hepatic surgery...
  23. ncbi Bile leak test by indocyanine green fluorescence images after hepatectomy
    Takanori Sakaguchi
    Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Surg 200:e19-23. 2010
    b>Bile leak remains a serious complication after hepatectomy. The conventional leak test by intrabiliary injection of normal saline solution is not sensitive...
  24. ncbi Impact of endoscopic intervention in 100 patients with suspected postcholecystectomy bile leak
    Arthur John Kaffes
    Gastrointest Endosc 61:269-75. 2005
    b>Bile leak is a recognized complication of cholecystectomy. Endoscopic intervention is widely accepted as a treatment for this complication, but the optimal form is not well defined.
  25. ncbi Large-scale identification of human biliary proteins from a cholesterol stone patient using a proteomic approach
    Hu Zhou
    Research Centre for Proteome Analysis, Key Lab of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
    Rapid Commun Mass Spectrom 19:3569-78. 2005
    Gallbladder bile, one of the most important body fluids, is composed of water, inorganic ions, conjugated bile salts, phospholipids, cholesterol, bilirubin, mucin and proteins...
  26. ncbi A step further in the analysis of human bile proteome
    Annarita Farina
    Biomedical Proteomics Research Group, Department of Bioinformatics and Structural Biology, Geneva University, Geneva CH 1211, Switzerland
    J Proteome Res 10:2047-63. 2011
    b>Bile was shown to collect proteins known as potential cancer biomarkers...
  27. ncbi Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging--correlation with expression of sinusoidal and canalicular transporters and bile accumulation
    Takahiro Tsuboyama
    Department of Radiology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Radiology 255:824-33. 2010
    ..To investigate the mechanism of enhancement of hepatocellular carcinoma (HCC) on gadoxetic acid-enhanced hepatobiliary phase magnetic resonance (MR) images and to characterize HCC thus enhanced...
  28. pmc Identification of a bile-induced exopolysaccharide required for Salmonella biofilm formation on gallstone surfaces
    Robert W Crawford
    Center for Microbial Interface Biology and Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 76:5341-9. 2008
    ..suggesting that this bacterium utilizes novel mechanisms to mediate enhanced colonization and persistence in a bile-rich environment...
  29. pmc Repair of DNA damage induced by bile salts in Salmonella enterica
    Ana I Prieto
    Departamento de Genetica, Facultad de Biologia, Universidad de Sevilla, Seville 41080, Spain
    Genetics 174:575-84. 2006
    ..or sodium glycochenodeoxycholate induces the SOS response, indicating that the DNA-damaging activity of bile resides in bile salts...
  30. ncbi DNA micro-array-based identification of bile-responsive genes in Lactobacillus plantarum
    P A Bron
    Wageningen Centre for Food Sciences, Wageningen, The Netherlands
    J Appl Microbiol 100:728-38. 2006
    The purpose of this study was to determine the global transcriptional response in a food-associated lactic acid bacterium during bile stress.
  31. ncbi Biliary lipids, water and cholesterol gallstones
    Karel J van Erpecum
    Department of Gastroenterology, University Hospital Utrecht, Utrecht, The Netherlands
    Biol Cell 97:815-22. 2005
    Cholesterol supersaturation, hydrophobic bile salts, pronucleating proteins and impaired gall-bladder motility may contribute to gallstone pathogenesis...
  32. ncbi ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion
    Michael A Cater
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Australia
    Gastroenterology 130:493-506. 2006
    The Wilson protein (ATP7B) regulates levels of systemic copper by excreting excess copper into bile. It is not clear whether ATP7B translocates excess intrahepatic copper directly across the canalicular membrane or sequesters this copper ..
  33. ncbi Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapy
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Gastroenterology 124:217-32. 2003
    Inborn errors of bile acid metabolism may present as neonatal cholestasis and fat-soluble vitamin malabsorption or as late onset chronic liver disease...
  34. pmc Vibrio cholerae OmpU and OmpT porins are differentially affected by bile
    Jamie A Wibbenmeyer
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Infect Immun 70:121-6. 2002
    ..It was recently shown that bile stimulates the ToxR-mediated transcription of ompU and that ompU-expressing strains are more resistant to bile and ..
  35. ncbi Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
    K E Berge
    Department of Molecular Genetics and McDermott Center for Human Growth and Development and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Science 290:1771-5. 2000
    ..These data suggest that ABCG5 and ABCG8 normally cooperate to limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of these transporters predispose to sterol accumulation and atherosclerosis...
  36. ncbi Bile-based detection of extrahepatic cholangiocarcinoma with quantitative DNA methylation markers and its high sensitivity
    So Hyun Shin
    Laboratory of Epigenetics, Cancer Research Institute, Seoul, South Korea
    J Mol Diagn 14:256-63. 2012
    Extrahepatic cholangiocarcinoma (EHC) is usually difficult to diagnose by bile cytology because of cellular disintegration. However, DNA samples from bile fluid can provide sufficient materials to screen for the presence of EHC...
  37. ncbi Review article: the role of bile and pepsin in the pathophysiology and treatment of gastro-oesophageal reflux disease
    J Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 24:10-6. 2006
    ..Animal studies suggest that synergism between acid and pepsin and conjugated bile acids have the greatest damaging potential for oesophageal mucosa, although unconjugated bile acids may be caustic ..
  38. ncbi Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19
    C Gälman
    Department of Endocrinology, Metabolism and Diabetes, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Intern Med 270:580-8. 2011
    b>Bile acid (BA) synthesis is essential in cholesterol and lipid homoeostasis.
  39. ncbi Shotgun proteomics of human bile in hilar cholangiocarcinoma
    Shahid G Farid
    Department of Hepatopancreaticobiliary Surgery, St James s University Hospital, Leeds, UK
    Proteomics 11:2134-8. 2011
    ..to find biomarkers for hepatobiliary diseases including cholangiocarcinoma (CCA) has led to an interest in using bile as a proximal fluid in biomarker discovery experiments, although there are inherent challenges both in its ..
  40. pmc A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol
    Eric L Klett
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
    BMC Med 2:5. 2004
    ..No phenotypic difference has yet been described in humans with complete defects in either ABCG5 or ABCG8. These proteins, based upon the defects in humans, are responsible for regulating dietary sterol entry and biliary sterol secretion...
  41. pmc Critical role of multidrug efflux pump CmeABC in bile resistance and in vivo colonization of Campylobacter jejuni
    Jun Lin
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio 44691, USA
    Infect Immun 71:4250-9. 2003
    ..In this study, we examined the role of CmeABC in bile resistance and its contribution to the adaptation of Campylobacter jejuni in the intestinal tract of the chicken, a ..
  42. ncbi Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1
    Torsten Plosch
    Center for Liver, Digestive, and Metabolic Diseases, Groningen University Institute for Drug Exploration, Department of Pediatrics, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Biol Chem 277:33870-7. 2002
    ..Thus, activation of LXR in mice leads to enhanced hepatobiliary cholesterol secretion and fecal neutral sterol loss independent of (ABCA1-mediated) elevation of HDL and the presence of ABCA1 in liver and intestine...
  43. ncbi Risk factors and management of postoperative bile leakage after hepatectomy without bilioenteric anastomosis
    Hiromichi Ishii
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan ishii0512h yahoo co jp
    Dig Surg 28:198-204. 2011
    b>Bile leakage frequently causes major complications after hepatic resection...
  44. pmc The role of cilia in the regulation of bile flow
    Nicholas F Larusso
    Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Dig Dis 29:6-12. 2011
    Cholangiocytes, the epithelial cells lining intrahepatic bile ducts, are ciliated cells...
  45. ncbi The White test: a new dye test for intraoperative detection of bile leakage during major liver resection
    Silvio Nadalin
    Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Arch Surg 143:402-4; discussion 404. 2008
    To describe a new intraoperative bile leakage test in patients undergoing a major liver resection aimed to combine the advantages of each of the other standard bile leakage tests (accurate visualization of leaks, reproducibility, and ease ..
  46. ncbi Bile tolerant Lactobacillus reuteri isolated from pig feces inhibits enteric bacterial pathogens and porcine rotavirus
    Byeong Joo Seo
    Department of Applied Microbiology and Biotechnology, Yeungnam University, Kyongsan, Kyeongbuk, South Korea
    Vet Res Commun 34:323-33. 2010
    ..This strain was resistant to pH 2.0, 5% porcine bile and exhibited antimicrobial activity against all the thirteen enteric bacterial pathogens tested...
  47. ncbi Helicobacter pylori protein response to human bile stress
    Chunhong Shao
    Department of Microbiology, School of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong 250012, PR China
    J Med Microbiol 57:151-8. 2008
    The ability of Helicobacter pylori to tolerate bile is likely to be important for its colonization and survival in the gastrointestinal tract of humans...
  48. pmc Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells
    E Jaensson-Gyllenbäck
    Department of Experimental Medical Sciences, Immunology Section, Lund University, Lund, Sweden
    Mucosal Immunol 4:438-47. 2011
    ..We found that bile contained high levels of retinol, induced RA receptor-dependent retinol-metabolizing activity in bone marrow-..
  49. ncbi Diagnosis and management of bile leaks after blunt liver injury
    Wendy L Wahl
    Trauma Burn Center, University of Michigan Health System, Ann Arbor 48109 0033, USA
    Surgery 138:742-7; discussion 747-8. 2005
    ..Furthermore, bile leaks are emerging as frequent complications of NOM...
  50. ncbi Bile leakage and liver resection: Where is the risk?
    Lorenzo Capussotti
    Unit of Surgical Oncology, Institute for Cancer Research and Treatment, Candiolo, Italy
    Arch Surg 141:690-4; discussion 695. 2006
    The knowledge of risk factors for bile leakage after liver resection could reduce its incidence.
  51. pmc Transformation of benign Barrett's epithelium by repeated acid and bile exposure over 65 weeks: a novel in vitro model
    Kiron M Das
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Int J Cancer 128:274-82. 2011
    ..The aim of the study is to determine if repeated exposure to acid and bile confers a tumorigenic phenotype in a telomerase (hTERT)-immortalized benign Barrett's cell line (BAR-T)...
  52. ncbi Cholestasis and cholestatic syndromes
    Gideon M Hirschfield
    Liver Centre, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, Canada
    Curr Opin Gastroenterol 25:175-9. 2009
    ..Cholestatic liver injury is encountered across a wide variety of clinical scenarios ranging from toxin-induced, genetic, to autoimmune in nature. This review summarizes recent findings from what is a burgeoning clinical field...
  53. ncbi Proteomic analysis of human bile and potential applications for cancer diagnosis
    Annarita Farina
    Biomedical Proteomics Research Group, Department of Bioinformatics and Structural Biology, Faculty of Medicine, Geneva University, Switzerland
    Expert Rev Proteomics 6:285-301. 2009
    b>Bile is a body fluid produced by the liver and drained by biliary ducts into the duodenum...
  54. ncbi Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats
    Vicente Lorenzo-Zúñiga
    Departments of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
    Hepatology 37:551-7. 2003
    Experiments were performed to test whether conjugated bile acid administration would decrease bacterial overgrowth, bacterial translocation, and endotoxemia in ascitic cirrhotic rats...
  55. ncbi Role of bile in pathogenesis of indomethacin-induced enteropathy
    Molly Jacob
    Department of Biochemistry, Christian Medical College, Vellore 632002, India
    Arch Toxicol 81:291-8. 2007
    ..These effects lead to increased intestinal permeability and inflammation. Luminal bile acids play a controversial role in the damage produced by these drugs...
  56. ncbi Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor
    Torsten Plosch
    Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
    Gastroenterology 126:290-300. 2004
    ..It has been proposed that ABCG5/ABCG8 heterodimers mediate secretion of plant sterols and cholesterol by hepatocytes into bile and their efflux from enterocytes into the intestinal lumen.
  57. pmc Effect of fatty acids and cholesterol present in bile on expression of virulence factors and motility of Vibrio cholerae
    Arpita Chatterjee
    Biophysics Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Calcutta 700 032, India
    Infect Immun 75:1946-53. 2007
    b>Bile induces pleiotropic responses that affect production of virulence factors, motility, and other phenotypes in the enteric pathogen Vibrio cholerae...
  58. ncbi Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria
    L Meerman
    Center for Liver, Digestive, and Metabolic Diseases, Groningen Institute for Drug Studies, Groningen, The Netherlands
    Gastroenterology 117:696-705. 1999
    ..METHODS: Liver histology, indicators of lipid peroxidation, plasma parameters of liver function, and bile composition were studied in mice homozygous (fch/fch) for a point mutation in the ferrochelatase gene and in ..
  59. ncbi Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles
    Peter Fickert
    Department of Medicine, Karl Franzens University, Graz, Austria
    Gastroenterology 123:1238-51. 2002
    The effects of ursodeoxycholic acid (UDCA) in biliary obstruction are unclear. We aimed to determine the effects of UDCA in bile duct-ligated and in Mdr2 knockout (Mdr2(-/-)) mice with biliary strictures.
  60. ncbi Biliary secretion and excretion in health and disease: current concepts
    Alan F Hofmann
    Division of Gastroenterology Department of Medicine University of California, San Diego California 92093 0813, USA
    Ann Hepatol 6:15-27. 2007
    ..biology have enabled cloning of the transporters involved in biliary secretion and the enterohepatic circulation of bile acids. This, in turn has permitted elucidation of their function as well as their regulation by nuclear receptors...
  61. pmc Physiology of bile secretion
    Alejandro Esteller
    Department of Physiology and Pharmacology, University of Salamanca, Campus Miguel de Unamuno, Salamanca 37007, Spain
    World J Gastroenterol 14:5641-9. 2008
    The formation of bile depends on the structural and functional integrity of the bile-secretory apparatus and its impairment, in different situations, results in the syndrome of cholestasis...
  62. pmc Salmonella enterica serovar typhimurium resistance to bile: identification and characterization of the tolQRA cluster
    Angela M Prouty
    Department of Microbiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Bacteriol 184:1270-6. 2002
    Salmonella enterica serovar Typhimurium is resistant to the action of bile salts, and resistance to bile is enhanced in strains in which the PhoP-PhoQ (PhoPQ) two-component regulatory system has been activated...
  63. pmc Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice
    Harmen Wiersma
    Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Lipid Res 50:1571-80. 2009
    High density lipoprotein cholesterol is thought to represent a preferred source of sterols secreted into bile following hepatic uptake by scavenger receptor class B type I (SR-BI)...
  64. ncbi Detection of hepatitis E virus in liver, mesenteric lymph node, serum, bile and faeces of naturally infected pigs affected by different pathological conditions
    Nilsa de Deus
    Centre de Recerca en Sanitat Animal CReSA, Campus de la UAB Edifici CReSA, 08193 Bellaterra Barcelona, Spain
    Vet Microbiol 119:105-14. 2007
    ..Serum, bile, liver, lymph nodes and faeces of 69 animals from 1 week to 4 months of age with different pathological conditions ..
  65. ncbi Comparative proteomics of excretory-secretory proteins released by the liver fluke Fasciola hepatica in sheep host bile and during in vitro culture ex host
    Russell M Morphew
    Institute of Biological Sciences, University of Wales, Aberystwyth, Wales SY23 3DA, United Kingdom
    Mol Cell Proteomics 6:963-72. 2007
    ..hepatica in vivo, within ovine host bile, with classical ex host in vitro ES methods. Only cathepsin L proteases from F...
  66. ncbi Role of the gastric refluxate in gastroesophageal reflux disease: acid, weak acid and bile
    Joel E Richter
    Department of Medicine and Section of Gastroenterology and Hepatology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Med Sci 338:89-95. 2009
    The role of acid, weak/nonacid, and bile in the genesis of esophageal mucosal damage and reflux symptoms is complex...
  67. ncbi Incidence and management of bile leakage after hepatic resection for malignant hepatic tumors
    Shogo Tanaka
    Department of Gastroenterological and Hepato Biliary Pancreatic Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japan
    J Am Coll Surg 195:484-9. 2002
    b>Bile leakage is one of the frequent and disturbing complications of hepatic resection.
  68. ncbi Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice
    Astrid Kosters
    Department of Experimental Hepatology, AMC Liver Center, Academic Medical Center, Meibergdreef 69 71, Amsterdam 1105 BK, The Netherlands
    J Hepatol 38:710-6. 2003
    ..The aim of our study was to correlate the expression levels of Abcg5 and Abcg8 to biliary cholesterol secretion in various (genetically-modified) mouse models...
  69. pmc Bile secretory function in the obese Zucker rat: evidence of cholestasis and altered canalicular transport function
    M Pizarro
    Departmento de Gastroenterologia, Pontificia Universidad Catolica de Chile, Santiago 833 0024, Chile
    Gut 53:1837-43. 2004
    Obese Zucker rats (ZR) have been used as an experimental model for non-alcoholic fatty liver disease and are particularly susceptible to various types of liver injury. Bile secretory function has not been assessed in ZR.
  70. ncbi Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS
    Lei Chwen Lin
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Pharm Biomed Anal 48:909-17. 2008
    ..was developed to determine gastrodin and its metabolite p-hydroxybenzyl alcohol (HBA) in rat blood, brain and bile collected using microdialysis technique. The analytes were separated using a reversed phase column (4...
  71. ncbi Separation and quantitation of bile acids using an isocratic solvent system for high performance liquid chromatography coupled to an evaporative light scattering detector
    E C Torchia
    Department of Biochemistry and Canadian Institutes of Health Research Group in Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
    Anal Biochem 298:293-8. 2001
    We developed a quantitative method for the analysis of bile acids using a high performance liquid chromatograph coupled to an evaporative light scattering detector...
  72. ncbi Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat
    Andreas Geier
    Department of Gastroenterology, Aachen University RWTH, Aachen, Germany
    J Hepatol 43:1021-30. 2005
    ..Alterations in hepatobiliary transporters may render fatty livers more vulnerable against various toxic insults...
  73. ncbi Endoscopic therapy for bile leak based on a new classification: results in 207 patients
    Gurpal S Sandha
    St Michael s Hospital, University of Toronto, Canada
    Gastrointest Endosc 60:567-74. 2004
    b>Bile leak is among the most common complications of cholecystectomy. Endoscopic therapy is empiric; a systematic approach to management of bile leak has not been established.
  74. pmc Cholic acid, a bile acid elicitor of hypersensitive cell death, pathogenesis-related protein synthesis, and phytoalexin accumulation in rice
    Jinichiro Koga
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, Sakado, Saitama 350 0289, Japan
    Plant Physiol 140:1475-83. 2006
    ..defense responses was isolated from human feces, and its structure was identified as cholic acid (CA), a primary bile acid in animals...
  75. ncbi ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile
    Silvia Langheim
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Lipid Res 46:1732-8. 2005
    The major pathway for the removal of cholesterol from the body is via secretion into the bile. Three members of the ATP binding cassette (ABC) family, ABCG5 (G5), ABCG8 (G8), and ABCB4 (MDR2), are required for the efficient biliary export ..
  76. pmc Enhancing bile tolerance improves survival and persistence of Bifidobacterium and Lactococcus in the murine gastrointestinal tract
    Debbie Watson
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    BMC Microbiol 8:176. 2008
    ..Herein we outline a patho-biotechnology strategy to improve gastric delivery and host adaptation of a probiotic strain Bifidobacterium breve UCC2003 and the generally regarded as safe (GRAS) organism Lactococcus lactis NZ9000...
  77. ncbi NPC2 is expressed in human and murine liver and secreted into bile: potential implications for body cholesterol homeostasis
    Andres Klein
    Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica, Santiago, Chile
    Hepatology 43:126-33. 2006
    ..plays a critical role in the metabolism of lipoprotein cholesterol and in controlling its elimination through the bile. Niemann-Pick type C 2 (NPC2), a cholesterol-binding protein, is key for normal intracellular trafficking of ..
  78. ncbi Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion
    Tsunehiro Shintani
    Department of Biochemistry and Integrative Medical Biology, Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Hepatology 49:141-50. 2009
    ..In the mouse model of estradiol-induced cholestasis, CO overproduction by inducing HO-1 significantly improved the bile output through stimulating HCO(3) (-) excretion; such a choleretic response did not occur in the knockout mice.
  79. pmc Bile acids: chemistry, physiology, and pathophysiology
    Maria J Monte
    Laboratory of Experimental Hepatology and Drug Targeting, CIBERehd, University of Salamanca, Salamanca 37007, Spain
    World J Gastroenterol 15:804-16. 2009
    The family of bile acids includes a group of molecular species of acidic steroids with very peculiar physical-chemical and biological characteristics...
  80. ncbi Quantitative analysis of bile acids in human plasma by liquid chromatography-electrospray tandem mass spectrometry: a simple and rapid one-step method
    Debora Tagliacozzi
    Laboratorio di Biochimica Clinica, Ospedale Pediatrico del Bambino Gesu IRCCS, Rome, Italy
    Clin Chem Lab Med 41:1633-41. 2003
    b>Bile acids play a pivotal role in the metabolism of cholesterol and lipids. Their blood concentrations are important prognostic and diagnostic indicators of hepatobiliary and intestinal dysfunction...
  81. pmc Transport systems in cholangiocytes: their role in bile formation and cholestasis
    M Strazzabosco
    Instituto di Medicina Interna, Azienda Ospedaliera di Padova, Universita di Padova, Padua, Italy
    Yale J Biol Med 70:427-34. 1997
    Formation of bile requires the coordinated function of two epithelial cell types: hepatocytes, that are responsible for secretion of the major osmolytes and biliary constituents and cholangiocytes that regulate the fluidity and alkalinity ..
  82. pmc A bile based study of Clonorchis sinensis infections in patients with biliary tract diseases in Ulsan, Korea
    Kwang Ro Joo
    Department of Internal Medicine, Kyung Hee University Hospital, 1 Hoigi dong, Dongdaemoon gu, Seoul 130 702, Korea
    Yonsei Med J 46:794-8. 2005
    ..We evaluated the infection states of CS in patients with biliary tract diseases using a bile sample...
  83. ncbi Identification of a novel type of CA19-9 carrier in human bile and sera of cancer patients: an implication of the involvement in nonsecretory exocytosis
    Naofumi Uozumi
    Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, 1 7 Yamada oka, Suita 565 0871, Japan
    J Proteome Res 9:6345-53. 2010
    ..Here we report the identification and characterization of a novel type of CA19-9 carrier, BGM (bile globular membrane), which is thought to exist in normal bile and to be secreted into sera of patients with ..
  84. pmc Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice
    Iván L Csanaky
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Hepatology 53:272-81. 2011
    ..However, the role of the Oatp1b family in the hepatic uptake of bile acids (BAs) into the liver is unknown...
  85. ncbi Prevention of pancreaticojejunal anastomotic leakage after pancreaticoduodenectomy with separate internal drainage of bile and pancreatic fluid
    Xian Wei Dai
    Department of General Surgery, Second Clinical College, China Medical University, Shenyang 110004, China
    Hepatobiliary Pancreat Dis Int 2:131-4. 2003
    ..To introduce a new reconstructional procedure to decrease the complications after pancreaticoduodenectomy...
  86. ncbi Characterization and quantification of rat bile phosphatidylcholine by electrospray-tandem mass spectrometry
    W D Lehmann
    Central Spectroscopy, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
    Anal Biochem 246:102-10. 1997
    Rat bile phosphatidylcholine was structurally characterized and quantified by electrospray mass spectrometry using a triple quadrupole instrument...
  87. ncbi Biliary lipid secretion, bile acid metabolism, and gallstone formation are not impaired in hepatic lipase-deficient mice
    Ludwig Amigo
    Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica, Santiago, Chile
    Hepatology 38:726-34. 2003
    ..This work characterizes plasma lipoprotein cholesterol, hepatic cholesterol content, bile acid metabolism, biliary cholesterol secretion, and gallstone formation in HL-deficient mice and C57BL/6 controls ..
  88. pmc Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid
    Lee R Hagey
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0063, USA
    Zoolog Sci 27:565-73. 2010
    The biliary bile salts of the medaka, the Japanese rice fish (Oryzias latipes) were isolated and identified. Only bile acids were present, and all were N-acylamidated with taurine...
  89. pmc Role of transporter proteins in bile tolerance of Lactobacillus acidophilus
    Erika A Pfeiler
    Genomic Sciences Graduate Program, Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USA
    Appl Environ Microbiol 75:6013-6. 2009
    ..mutations in the transporter genes LBA0552, LBA1429, LBA1446, and LBA1679 exhibited increased sensitivity to bile. These strains showed unique patterns of sensitivity to a variety of inhibitory compounds, as well as differential ..
  90. ncbi Lipopolysaccharides and beta-glucuronidase activity in choledochal bile in relation to choledocholithiasis
    T Osnes
    Section of Gastroenterology, Ulleval Hospital, Oslo, Norway
    Digestion 58:437-43. 1997
    ..Common duct bile obtained at endoscopic retrograde cholangiography in 86 patients was assayed for LPS by a limulus amebocyte lysate ..
  91. ncbi Determination and pharmacokinetic analysis of salvianolic acid B in rat blood and bile by microdialysis and liquid chromatography
    Yen Fei Chen
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    J Chromatogr A 1088:140-5. 2005
    ..chromatography has been developed for continuous monitoring of protein-unbound salvianolic acid B in rat blood and bile. Microdialysis probes were inserted into the jugular vein/right atrium and bile duct of Sprague-Dawley rats, and a ..
  92. ncbi [Effects of ursolic acid on liver-protection and bile secretion]
    Xiaojuan Xiong
    Yichun College, Yichun, Jiangxi 336000
    Zhong Yao Cai 26:578-81. 2003
    To study the liver-protection and promoting bile secretion of ursolic acid.
  93. pmc Presence of hepcidin-25 in biological fluids: bile, ascitic and pleural fluids
    Jayantha Arnold
    Department of Gastroenterology, Ealing Hospital NHS Trust, Uxbridge Road, London UB1 3HW, United Kingdom
    World J Gastroenterol 16:2129-33. 2010
    To examine body fluids such as ascitic fluid (AF), saliva, bile and pleural effusions for the presence of hepcidin using a novel radioimmunoassay (RIA).
  94. ncbi Origin of oxysterols in hepatic bile of patients with biliary infection
    Tadashi Yoshida
    Division of Gastroenterology, Tsukuba Memorial Hospital and Institute of Clinical Medicine, University of Tsukuba, Japan
    Am J Gastroenterol 98:2275-80. 2003
    ..Although bile contains high concentrations of cholesterol, oxysterol concentrations in bile and the effect of infection on ..
  95. ncbi The application of HPLC-F and GC-MS to the analysis of selected hydroxy polycyclic hydrocarbons in two certified fish bile reference materials
    Grete Jonsson
    RF Akvamiljø, Mekjarvik 12, N 4070 Randaberg, Norway
    J Environ Monit 5:513-20. 2003
    ..1-hydroxy-pyrene (1-OH-PYR) and 3-hydroxy-benzo[a]pyrene (3-OH-BaP) have been analysed in two certified fish bile reference materials (CRMs) for exposure monitoring of PAHs in the aquatic environment...
  96. pmc Bile-inducible efflux transporter from Bifidobacterium longum NCC2705, conferring bile resistance
    Miguel Gueimonde
    Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias IPLA, Consejo Superior de Investigaciones Cientificas CSIC, Villaviciosa, Asturias, Spain
    Appl Environ Microbiol 75:3153-60. 2009
    ..In order to exert their health benefits, these bacteria must overcome biological barriers, including bile salts, to colonize and survive in specific parts of the intestinal tract...
  97. ncbi From blood to bile: recent advances in hepatobiliary transport
    Marco Arrese
    Departament of Gastroenterology, Catholic University of Chile School of Medicine, Santiago, Chile
    Ann Hepatol 1:64-71. 2002
    Transport of endogenous and exogenous substances from blood to bile is an essential function of the liver...
  98. ncbi Identification of oxysterols in human bile and pigment gallstones
    W G Haigh
    Department of Medicine, VA Medical Center, Seattle, Washington 98195, USA
    Gastroenterology 121:118-23. 2001
    ..However, the presence of oxysterols in bile or gallstones has never been reported. METHODS: Fresh human bile and gallstones were collected...
  99. ncbi [Effect of hypolipidemic treatment on the composition of bile and the risk or cholesterol gallstone disease]
    A Zak
    IV interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 146:24-34. 2007
    ..The degree of cholesterol saturation in gallbladder bile is the most important predictor of cholesterol crystal formation...
  100. ncbi Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats
    Gianfranco Alpini
    Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center College of Medicine, and Central Texas Veterans Health Care System, Temple, Texas, USA
    Gastroenterology 123:1226-37. 2002
    We tested the hypothesis that during bile duct obstruction, increased biliary bile acids trigger cholangiocyte proliferation and secretion by a phosphatidylinositol 3-kinase (PI3-K)-dependent pathway.
  101. ncbi Role of duodenal bile crystal analysis in idiopathic pancreatitis
    S K Sahoo
    Department of General Surgery, S.C.B. Medical College and Hospital, Cuttack 753007, Orissa, India
    Trop Gastroenterol 22:205-6. 2001
    BACKGROUND/AIM: The aim of this study was to find out the incidence and clinical use of duodenal bile crystal analysis in patients presenting with idiopathic pancreatitis...

Research Grants73

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..technology to join and seal tissues for controlling the leakage of blood, gastrointestinal fluids, urine, bile, lymph, and cerebrospinal fluid...
  2. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..of exogenous compounds such as drugs or toxins as well as endogenous compounds like hormones, bilirubin and bile acids and cholesterol. Liver-based metabolic disease can result from mutations in genes in these critical pathways...
  3. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..In vivo VLDL production, hepatic lipid content, lipogenesis, bile acid synthesis, and -oxidation will be measured in rodents fed betaine...
  4. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..of which there are numerous members throughout the bacterial world, is inhibited by fatty acids present in bile. In the structure of ToxT, a palmitoleic acid bridges the regulatory and DNA binding domains of the transcription ..
  5. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    ..Recent studies have shown that bile acids not only are physiological detergents that facilitate absorption, transport, distribution and disposal of ..
  6. Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid Metabolism
    HUIPING ROSE ZHOU; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bile acids are crucial for lipid homeostasis in the liver. During the last decade, researchers have discovered that bile acids not only act as detergents, but also as important signaling molecules...
  7. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..and signaling of GI hormones (GLP-1, PYY, and ghrelin), and the adipocyte hormone, adiponectin and by altering bile acid metabolism and intestinal microflora...
  8. Microsomal Cytochromes P450 and their Interactions with their Redox Partners
    Lucy A Waskell; Fiscal Year: 2013
    ..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
  9. Histamine modulation of biliary proliferation and damage
    Heather L Francis; Fiscal Year: 2013
    ..Cholangiocytes are epithelial cells lining the bile ducts and are responsible for the modification and release of bile into the duodenum...
  10. Role of Platelet derived growth factor receptor-a in Liver Patho-biology
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..Lastly, PDGFR[unreadable] upregulation was observed in hepatocytes during hepatic fibrosis in patients, and after bile duct ligation (BDL) in mice...
  11. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2013
    ..acts in an endocrine fashion to regulate major metabolic processes including glucose, lipid, cholesterol, and bile acid metabolism, and phosphate/vitamin D homeostasis...
  12. Lipid Transport, Bile Acid Synthesis, and Cholesterol Homeostasis
    William M Pandak; Fiscal Year: 2013
    ..nuclear receptors that control the expression of genes involved in the regulation of cholesterol, fatty acid, and bile acid homeostasis;and, subsequently determining how expression of the encoded pathways correlates with respective ..
  13. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..Release of BDNF will be determined in response to physiological stimuli (mucosal stroking, free fatty acids, and bile salts), to neurotransmitters (CGRP and SP), and to paracrine agents (5-HT and endocannabinoids) known to mediate or ..
  14. Liver disease in CF: CFTR controls innate immunity in biliary epithelium
    Mario Strazzabosco; Fiscal Year: 2013
    ..In Cftr-KO mice, bile flow and biliary secretion are reduced;however the spontaneous development of CFLD is extremely rare, suggesting ..
  15. NPC1L1 and Metabolic Diseases
    Liqing Yu; Fiscal Year: 2013
    ..To probe the molecular link between NPC1L1 deficiency and D2 activation, we will examine if bile acid metabolism differs between WT and L1KO mice on HFD because we found that many bile acid sensitive genes were ..
  16. Dietary Cholesterol and Defects in Cholesterol Synthesis
    ROBERT DAVID STEINER; Fiscal Year: 2013
    ..We further hypothesize that statins, bile acids, antioxidants and molecular chaperones selectively restore SLOS cell metabolism and function...
  17. Excessive Copper Levels Disrupt Hepatic Nuclear Receptor Function
    Clavia Ruth Wooton-Kee; Fiscal Year: 2011
    ..LEC) rat and Atp7b-/- mouse) have decreased expression of genes involved in several metabolic pathways, including bile acid synthesis (cholesterol 71-hydroxylase (Cyp7a1)), cholesterol synthesis (3-hydroxy-3-methyl-glutaryl-CoA ..
  18. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN JD O'KEEFE; Fiscal Year: 2012
    ..Our studies have also showed higher populations of secondary bile salt producing bacteria in AAs which are stimulated by high animal fat diets to produce carcinogenic secondary bile ..
  19. New pathways regulating bile acid homeostasis and cholestatic liver diseases
    Li Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The conversion to bile acids represents a major pathway for cholesterol elimination from the body, which is therefore of critical importance in maintaining cholesterol homeostasis...
  20. Biliary Atresia, Cholestatic Liver Diseases, and Cystic Fibrosis: Indiana Univers
    Jean Pappas Molleston; Fiscal Year: 2013
    ..Alagille's syndrome, alpha-1-antitrypsin deficiency, Progressive Familial Intrahepatic Cholestasis (PFIC), bile acid synthetic defects, mitochondrial hepatopathies, and cystic fibrosis...
  21. Regulation of Bile Acid Synthesis by Nuclear Receptors in Vivo
    Gregorio Gil; Fiscal Year: 2012
    b>Bile acids are required for intestinal absorption and biliary solubilization of cholesterol and lipids. In addition, bile acids play a crucial role in cholesterol homeostasis...
  22. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2012
    Gallstone pancreatitis is common and is potentially fatal. Enteral exclusion of bile-pancreatic juice by the stone causes feedback hyperstimulation of the exocrine pancreas that induces pancreatic overproduction of acute inflammatory ..
  23. DYSREGULATION OF GSH SYNTHESIS DURING LIVER INJURY AND FIBROSIS
    SHELLY CHI LOO LU; Fiscal Year: 2013
    ..They will complement in vivo studies in mice treated with bile duct ligation or LPS...
  24. Colorado Center for Childhood Liver Disease Research and Education
    Ronald J Sokol; Fiscal Year: 2013
    ..In cholestasis, impairment of bile flow leads to the accumulation of hepatotoxic bile acids, cholesterol and other compounds that produce liver injury ..
  25. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The apical sodium-dependent bile acid transporter (ASBT) is the major carrier protein involved in intestinal reclamation of bile salts...
  26. Mouse models for esophageal Cox-2 oxidative stress and DNA damage
    John P Lynch; Fiscal Year: 2013
    ..It occurs in response to chronic acid and bile reflux and is an important risk factor for the development of esophageal adenocarcinoma (EAC)...
  27. The Pittsburgh Cholestatic Liver Disease Consortium
    Benjamin L Shneider; Fiscal Year: 2013
    Neonatal cholestatic liver diseases including Alagille syndrome, alpha-1 antitrypsin deficiency, bile acid synthesis defects, biliary atresia, cystic fibrosis, mitochondrial hepatopathies and progressive familial intrahepatic cholestasis,..
  28. Molecular &Cellular Effects of Human Mutations in Cytochrome P450 Reductase
    Satya Prakash Panda; Fiscal Year: 2013
    ..a large family of enzymes responsible for such diverse reactions as drug and xenobiotic metabolism, steroid and bile acid biosynthesis, and fatty acid and eicosanoid hydroxylation...
  29. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2013
    ..Also, during weaning there were developmentally increasing levels of both intestinal bile acid and ileal bile acid uptake transporter (apical sodium-dependent bile acid transporter, ASBT) which may be ..
  30. Regulation of Bacteroides fragilis multidrug efflux pumps
    Hannah Wexler; Fiscal Year: 2013
    ..and in resistance could be induced by a variety of agents and stressors including antimicrobials, salicylate, bile and quorum sensing molecules...
  31. Breakthroughs to advance the in vitro propagation of human noroviruses
    Qiuhong Wang; Fiscal Year: 2010
    ..propagate HuNoVs in vitro include: 1) Mediators in the intestinal micro-environment (intestinal content filtrates, bile acids) that promote in vitro replication of porcine SaV;2) Role of innate immunity in inhibiting murine NoV (MNV) ..
  32. The Role of Cyp2b in Toxicant Metabolism and Sensitivity
    William S Baldwin; Fiscal Year: 2012
    ..cytochrome P450s (CYPs) are key enzymes involved in the detoxification of numerous chemicals including steroids, bile acids, pharmaceuticals, and environmental chemicals...
  33. Translational Research and Evolving Alcoholic hepatitis Treatment (TREAT-IU)
    David W Crabb; Fiscal Year: 2013
    ..understand its pathogenesis and to develop novel treatments, and (b) alcohol-induced impairment of signaling via bile salt receptors impairs gut integrity, permits activation of Kupffer cells, enhances oxidative stress in the liver, ..
  34. Epigenetic regulation of liver transporters
    Frederick J Suchy; Fiscal Year: 2013
    ..recruitment of coregulators associated with ligand-induced activation of FXR, a prototypical nuclear receptor for bile acids, regulate the expression of liver transport proteins in the normal liver and during cholestasis...
  35. Functions of the Human OST-alpha and OST-beta Proteins
    Patricia M Hinkle; Fiscal Year: 2013
    ..to advance understanding of mechanisms of disposition of the two major classes of cholesterol metabolites, namely bile acids and steroid conjugates, compounds that play important roles in a number of biological processes and human ..
  36. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2012
    ..We will use Ad -/- mice subjected to either CCl4 or common bile-duct ligation (CBDL) for induction of fibrosis and administer recombinant adiponectin...
  37. CELLS PROCESSING HIGH DENSITY LIPOPROTEINS
    Salman Azhar; Fiscal Year: 2013
    ..route for the delivery of CEs to the liver and steroidogenic tissues of rodents and humans for the biosynthesis of bile acids and steroid hormones, respectively...
  38. Thyroid-adrenergic synergism and adaptive thermogenesis
    Antonio C Bianco; Fiscal Year: 2013
    ..these mechanisms can be modulated by a wide variety of signaling molecules such as the hedgehog family of proteins, bile acids, HIF-1, NF-B, and a number of xenobiotic substances...
  39. The role of regulatory T cells in biliary atresia
    Alexander Miethke; Fiscal Year: 2013
    ..lymphocytes and attenuated the BA phenotype, as evidenced by lower serum bilirubin levels and reduced inflammatory bile duct obstruction...
  40. Crosstalk between estrogen and bile acid signaling pathway
    Ruitang Deng; Fiscal Year: 2013
    ..b>Bile acids are metabolites of cholesterol and have been identified as a class of signaling molecules for nuclear ..
  41. A Microfluidic-platform Mini-Liver System for Human Liver Biology Studies
    HONGSEOK M NOH; Fiscal Year: 2010
    ..develop a simple hepatocyte/collagen/LSEC sandwiched configuration and then expand this to include a channel for bile removal and, if necessary, additional sinusoid resident cells such as Kupffer or stellate cells...
  42. Treatment of Acute Coronary Syndromes with Recombinant LCAT Infusion
    BRIAN ROBERT KRAUSE; Fiscal Year: 2011
    ..Normally, cholesterol is removed from arteries and delivered to the liver for excretion into bile by a multistep process known as "Reverse Cholesterol Transport" (RCT)...
  43. Vibrio cholerae-host interaction at the Intestinal Interface
    Jun Zhu; Fiscal Year: 2013
    ..We have successfully purified and identified VIF-1 as taurocholic acid, a bile acid. Preliminary studies suggest that VIF-1 enhances the activity of TcpP...
  44. USC Research Center for Liver Disease
    Neil Kaplowitz; Fiscal Year: 2013
    ..Current projects include studies of: a) farnesoid X receptor, bile acids and liver regeneration;b) the role of Myc-max and Mnt-max in regulation of p53 and cyclin D1 by toxic bile ..
  45. The Role of Fibrocytes in Liver Fibrosis
    Tatiana Kisseleva; Fiscal Year: 2012
    ..signals in the course of liver fibrosis using two models of liver injury, carbontetrachloride (CCl4 and bile duct ligation (BDL). We anticipate that fibrocytes play an important role in pathogenesis of liver fibrosis (AIM 1)...
  46. (PQA1) Mechanism of Vitamin D Chemoprevention Against Colon Cancer
    Yan Chun Li; Fiscal Year: 2013
    ..Secondary bile acids (BA) are potent colon cancer promoters...
  47. Role of liver fluke granulin in cholangiocarcinogenesis
    Jason P Mulvenna; Fiscal Year: 2013
    ..parasites Opisthorchis viverrini and Clonorchis sinensis is a strong risk factor for cholangiocarcinoma (CCA), bile duct cancer, in Thailand, Laos and other locations in East Asia where infection is endemic...
  48. Extracellular Replication of Listeria in Vivo
    Christopher H Contag; Fiscal Year: 2010
    ..The major bile resistance locus bilE is dispensable for replication in the gallbladder...
  49. Participation in Cytochrome b5 in Anesthetic Metabolism
    Lucy A Waskell; Fiscal Year: 2010
    ..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
  50. Role of FoxO1 in Lipid Metabolism
    REBECCA ANNE HAEUSLER; Fiscal Year: 2013
    ..In preliminary data, I demonstrate a heretofore unknown link between the canonical Akt-FoxO pathway, bile acid (BA) composition, and lipid synthesis...
  51. Regulation of cholesterol catabolism by bile acids
    Jongsook Kim Kemper; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The overall goal of this project is to understand the role of bile acids as recently recognized key signaling molecules that control integrative metabolism and energy balance and the dysfunction of ..
  52. Structural Biology of the Apical Bile Acid Transporter.
    Peter W Swaan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The apical sodium-dependent bile acid transporter (ASBT) plays a key role in the enterohepatic recycling of bile salts, cholesterol homeostasis, and serves as a molecular target for ..
  53. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 2009
    Project Summary Bile acids are physiological detergents that generate bile flow and facilitate intestine absorption and transport of lipids, nutrients and vitamins...
  54. The Role of Genetics in Innate Immunity Following Cholestasis
    Samuel M Alaish; Fiscal Year: 2011
    ..A description of the research project follows: Defined as little or no bile flow, cholestasis is a common condition associated with significant and sometimes devastating complications in both ..
  55. Regulation of Hepatic Metabolic Function by Parenteral Nutrition
    Douglas G Burrin; Fiscal Year: 2013
    ..We will use in vivo metabolic (13C-bile acid turnover and 13C-palmitate oxidation kinetics) and liver transcriptomic and metabolomic approaches to ..
  56. Heme trafficking and its impact on systemic iron homeostasis
    Janis L Abkowitz; Fiscal Year: 2010
    ..to liver by studying Flvcrflox/flox;alb-cre mice; determine if hepatocytes can secrete heme via FLVCR into the bile permitting iron to exit the body;and explore the implications of these findings in models of hemolysis, chronic ..
  57. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    JOHN GRIDER; Fiscal Year: 2009
    ..Release of BDNF will be determined in response to physiological stimuli (mucosal stroking, free fatty acids, and bile salts), to neurotransmitters (CGRP and SP), and to paracrine agents (5-HT and endocannabinoids) known to mediate or ..
  58. Structure/Function of Steroid Transforming AKR's
    Trevor M Penning; Fiscal Year: 2011
    ..a first step in the elimination of steroid hormones, and an essential step in the synthesis of all bile-acids...
  59. Heme trafficking and its impact on systemic iron homeostasis
    Janis L Abkowitz; Fiscal Year: 2013
    ..to liver by studying Flvcrflox/flox;alb-cre mice;determine if hepatocytes can secrete heme via FLVCR into the bile permitting iron to exit the body;and explore the implications of these findings in models of hemolysis, chronic ..
  60. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    John Y L Chiang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bile acids are physiological detergents that generate bile flow and facilitate intestine absorption and transport of lipids, nutrients and vitamins...
  61. Bile Acids, Genetic Control and Colonic Function in Irritable Bowel Syndrome
    MICHAEL L CAMILLERI; Fiscal Year: 2013
    ..The etiological factors that impact on all these functions include endogenous substances, like bile acids (BA)...
  62. Characterization of Diet1, a hypercholesterolemia resistance gene
    Karen Reue; Fiscal Year: 2013
    ..Diet1 is expressed in the small intestinal epithelial cells, and we hypothesize that it functions in intracellular bile acid transport...
  63. REGULATION OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 1999
    The conversion of cholesterol to bile acids in the liver is the major pathway for the catabolism of cholesterol and plays an important role in the maintenance of cholesterol homeostasis...
  64. Bile acid-induced colon cancer cell proliferation
    Jean Pierre Raufman; Fiscal Year: 2009
    The central hypothesis to be tested in this proposal is that bile acids induce colon cancer cell proliferation by interaction with M3 muscarinic receptors (M3R), thereby causing transactivation of epidermal growth factor receptors (EGFR)...
  65. INTRACELLULAR TRANSPORT OF AMPHIPATHS
    Bruce Luxon; Fiscal Year: 2000
    ..the mechanism underlying the cytoplasmic transport of amphipathic molecules like long-chain fatty acids and bile acids...
  66. Understanding the role of bile as a mechanism for improved glucose homeostasis fo
    APRIL DAWN STRADER; Fiscal Year: 2010
    ..result in the resolution of type-II diabetes is the exposure of the lower intestine to higher concentrations of bile salts. As mentioned above, the interposed ileum is exposed to high concentrations of biliopancreatic secretions...
  67. PHYSICAL CHEMISTRY OF BILIRUBIN & ITS CONJUGATES
    WILLIAM SPIVAK; Fiscal Year: 1990
    ..gallstones and are essential parts of the matrix of pigment gallstones, biliary sludge and the insoluble bile pigment precipitates which clog the bile ductules and canaliculi of patients with cholestatic liver disease...
  68. EFFECTS OF BILE ACIDS ON CALCIUM AND IRON ABSORPTION
    Edward Moore; Fiscal Year: 1990
    Several previous studies have shown that whole bile and/or bile salts enhance absorption of both iron and calcium...
  69. URSODIOL-METHOTREXATE FOR PRIMARY BILIARY CIRRHOSIS
    Burton Combes; Fiscal Year: 2003
    ..PBC is a chronic cholestatic liver disease, predominantly of women, in which interlobular and septal bile ducts undergo inflammation and destruction. Once initiated, the disease persists and progresses at varying rates...
  70. MOLECULAR PHYSIOLOGY OF BILIARY LIPID SECRETION
    David Cohen; Fiscal Year: 2000
    b>Bile is the principal pathway for cholesterol elimination from the body, and abnormalities in bile secretion may result in gallstone formation, cholestasis, biliary cirrhosis, hypercholesterolemia and fat malabsorption...
  71. NEURAL CONTROL OF THE GALLBLADDER
    Gary M Mawe; Fiscal Year: 2010
    ..reports suggest that decreased gallbladder motility is caused by elevated cholesterol and hydrophobic salts in the bile, and that ensuing inflammation and impairments in gallbladder emptying lead to stone formation...
  72. HEPATIC DRUG ELIMINATION IN PREGNANCY
    Mary Vore; Fiscal Year: 2010
    ..transporter that mediates the biliary excretion of glucuronide and glutathione conjugates from the hepatocyte into bile. The proposal builds on our findings that 1) MRP2 transports tauroursodeoxycholate (TUDC), a bile acid used for the ..
  73. HEPATIC DRUG ELIMINATION IN PREGNANCY
    Mary Vore; Fiscal Year: 2007
    ..transporter that mediates the biliary excretion of glucuronide and glutathione conjugates from the hepatocyte into bile. The proposal builds on our findings that 1) MRP2 transports tauroursodeoxycholate (TUDC), a bile acid used for the ..