median eminence

Summary

Summary: Raised area at the infundibular region of the HYPOTHALAMUS at the floor of the BRAIN, ventral to the THIRD VENTRICLE and adjacent to the ARCUATE NUCLEUS. It contains the terminals of hypothalamic neurons and the capillary network of hypophyseal portal system, thus serving as a neuroendocrine link between the brain and the PITUITARY GLAND.

Top Publications

  1. pmc Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
    Daniel A Lee
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 15:700-2. 2012
  2. ncbi Expression of brain-derived neurotrophic factor and its receptors in the median eminence cells with sensitivity to stress
    Laurent Givalois
    Cerebral Plasticity Laboratory, Formation de Recherche en Evolution 2693 Centre National de la Recherche Scientifique, University of Montpellier II, Place Eugene Bataillon, 34095 Montpellier, France
    Endocrinology 145:4737-47. 2004
  3. ncbi Soluble factors guide gonadotropin-releasing hormone axonal targeting to the median eminence
    M J Gibson
    Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 141:3065-71. 2000
  4. pmc Expression of fos and in vivo median eminence release of LHRH identifies an active role for preoptic area kisspeptin neurons in synchronized surges of LH and LHRH in the ewe
    Gloria E Hoffman
    Department of Biology, Morgan State University, 1700 East Cold Spring Lane, Baltimore, Maryland 21251, USA
    Endocrinology 152:214-22. 2011
  5. ncbi Expression of a dominant negative FGF receptor in developing GNRH1 neurons disrupts axon outgrowth and targeting to the median eminence
    John C Gill
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    Biol Reprod 74:463-72. 2006
  6. ncbi Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence
    Jeremy T Smith
    Department of Physiology, Building 13F, Monash University, Clayton, Victoria 3880, Australia
    Endocrinology 152:1001-12. 2011
  7. ncbi The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: the former opens to the portal blood and the latter to the cerebrospinal fluid
    Esteban M Rodriguez
    Facultad de Medicina, Instituto de Anatomia, Histologia y Patologia, Universidad Austral de Chile, Valdivia, Chile
    Peptides 31:757-76. 2010
  8. pmc An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo
    Kim L Keen
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin 53715 1299, USA
    Endocrinology 149:4151-7. 2008
  9. pmc Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques
    Dominique H Eghlidi
    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Endocrinology 151:3783-94. 2010
  10. pmc Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence
    Edith Sanchez
    Tupper Research Institute and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, 750 Washington Street, Boston, Massachusetts 02111, USA
    Endocrinology 150:2283-91. 2009

Research Grants

  1. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
  2. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2013
  3. Optical Study of Secretion in Mammalian Nerve Terminals
    BRIAN MATTHEW SALZBERG; Fiscal Year: 2013
  4. Tanycytes and Nonthyroidal Illness
    RONALD MICHAEL LECHAN; Fiscal Year: 2010
  5. NEUROENDOCRINE CONTROL OF SEASONALITY
    Robert L Goodman; Fiscal Year: 2013
  6. Role of Notch signaling in the Development and Guidance of Hypothalamic Neurons
    PAVEN AUJLA; Fiscal Year: 2013
  7. NEUROTENSIN SYNTHESIS IN ARCUATE NEUROSECRETORY CELLS
    Mark Alexander; Fiscal Year: 1999
  8. BRAIN GENES GOVERNING REPRODUCTION
    Robert Steiner; Fiscal Year: 2005
  9. Hypothalamic Type 2 Deiodinase in Metabolism Regulation
    Sabrina Diano; Fiscal Year: 2005
  10. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    SARAH LEIBOWITZ; Fiscal Year: 2004

Detail Information

Publications226 found, 100 shown here

  1. pmc Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
    Daniel A Lee
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 15:700-2. 2012
    ..Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons...
  2. ncbi Expression of brain-derived neurotrophic factor and its receptors in the median eminence cells with sensitivity to stress
    Laurent Givalois
    Cerebral Plasticity Laboratory, Formation de Recherche en Evolution 2693 Centre National de la Recherche Scientifique, University of Montpellier II, Place Eugene Bataillon, 34095 Montpellier, France
    Endocrinology 145:4737-47. 2004
    The median eminence (ME) is considered as the final common pathway connecting the nervous and endocrine systems...
  3. ncbi Soluble factors guide gonadotropin-releasing hormone axonal targeting to the median eminence
    M J Gibson
    Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 141:3065-71. 2000
    Axons of GnRH neurons terminate at the median eminence in the medial basal hypothalamus (MBH) of the brain early in development...
  4. pmc Expression of fos and in vivo median eminence release of LHRH identifies an active role for preoptic area kisspeptin neurons in synchronized surges of LH and LHRH in the ewe
    Gloria E Hoffman
    Department of Biology, Morgan State University, 1700 East Cold Spring Lane, Baltimore, Maryland 21251, USA
    Endocrinology 152:214-22. 2011
    ..With a modified push-pull cannula in vivo LHRH release from the median eminence was sampled in luteal phase ewes, ewes undergoing an LH surge for 2-4 h, and postsurge animals whose LH surge ..
  5. ncbi Expression of a dominant negative FGF receptor in developing GNRH1 neurons disrupts axon outgrowth and targeting to the median eminence
    John C Gill
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    Biol Reprod 74:463-72. 2006
    ..neurons that synthesize and release gonadotropin-releasing hormone (GNRH1) extend their axons to the median eminence (ME) to establish neurosecretory contacts necessary for hormone secretion...
  6. ncbi Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence
    Jeremy T Smith
    Department of Physiology, Building 13F, Monash University, Clayton, Victoria 3880, Australia
    Endocrinology 152:1001-12. 2011
    ..stimulation of GnRH neurons, we examined the origin of kisspeptin neuronal fibers in the external zone of the median eminence (ME) using neuronal tracing and immunohistochemical techniques...
  7. ncbi The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: the former opens to the portal blood and the latter to the cerebrospinal fluid
    Esteban M Rodriguez
    Facultad de Medicina, Instituto de Anatomia, Histologia y Patologia, Universidad Austral de Chile, Valdivia, Chile
    Peptides 31:757-76. 2010
    ..located at the endothelial cells and in the circumventricular organs, such as the choroid plexuses (CP) and median eminence (ME), is displaced to specialized ependymal cells...
  8. pmc An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo
    Kim L Keen
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin 53715 1299, USA
    Endocrinology 149:4151-7. 2008
    ..This study measures the release of kisspeptin-54 in the stalk-median eminence (S-ME) during puberty and examines its potential role in the pubertal increase in LHRH-1 release in female ..
  9. pmc Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques
    Dominique H Eghlidi
    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Endocrinology 151:3783-94. 2010
    ..3 receptor (encoded by NK3), and kappa-opioid receptor (encoded by KOR), in the female rhesus macaque ARC-median eminence (ARC-ME)...
  10. pmc Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence
    Edith Sanchez
    Tupper Research Institute and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, 750 Washington Street, Boston, Massachusetts 02111, USA
    Endocrinology 150:2283-91. 2009
    ..Whether PPII has any role in the region where axons containing hypophysiotropic TRH terminate, the median eminence, is unknown...
  11. ncbi Gene expression in arcuate nucleus-median eminence of rats treated with leptin or ciliary neurotrophic factor
    Suresh Ambati
    Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602 2771, USA
    Biofactors 31:133-44. 2007
    ..ICV) injection of leptin and CNTF on gene expression in micropunched hypothalamic arcuate nucleus-median eminence (ARC-ME) complex samples from rats...
  12. ncbi Photoperiodically driven changes in Fos expression within the basal tuberal hypothalamus and median eminence of Japanese quail
    S L Meddle
    Biotechnology and Biological Sciences Research Council Group on Photoperiodism and Reproduction, School of Biological Sciences, University of Bristol, Bristol BS8 1UG, United Kingdom
    J Neurosci 17:8909-18. 1997
    ..Importantly, this activation occurred before the LH rise. Median eminence activation appeared within glial cells, whereas activated infundibular nucleus cells were neuronal, providing ..
  13. ncbi Identification of cGnRH-II in the median eminence of Japanese quail (Coturnix coturnix japonica)
    Stefan Clerens
    Laboratory of Neuroendocrinology and Immunological Biotechnology, Katholieke Universiteit Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Gen Comp Endocrinol 131:48-56. 2003
    ..we described the presence of cGnRH-II in the quail (Coturnix coturnix japonica) and chicken (Gallus gallus) median eminence using highly specific antibodies directed against a polypeptide corresponding to the C-terminal portion of ..
  14. ncbi Alternate cadmium exposure differentially affects the content of gamma-aminobutyric acid (GABA) and taurine within the hypothalamus, median eminence, striatum and prefrontal cortex of male rats
    A I Esquifino
    , Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Arch Toxicol 75:127-33. 2001
    ..In control rats GABA content decreased with age in the median eminence and in anterior, mediobasal and posterior hypothalamus, prefrontal cortex and the striatum...
  15. ncbi A novel developmental role for kisspeptin in the growth of gonadotrophin-releasing hormone neurites to the median eminence in the mouse
    Z Fiorini
    Centre for Neuroendocrinology, Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    J Neuroendocrinol 22:1113-25. 2010
    ..in other neurones, we investigated whether KISS1 may play a role in the normal growth of GnRH neurites to the median eminence. A reverse transcription-polymerase chain reaction demonstrated the expression of Kiss1 mRNA in the embryonic ..
  16. ncbi Capsaicin increases GFAP and glutamine synthetase immunoreactivity in rat arcuate nucleus and median eminence
    Chuma O Okere
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuroreport 15:255-8. 2004
    ..c. capsaicin (after 75 min) on astroglial cells in the rat arcuate nucleus-median eminence (ARC-ME). Compared to vehicle, capsaicin significantly increased GFAP and GS immunoreactivity in the ARC-ME...
  17. pmc Progesterone decreases tyrosine hydroxylase phosphorylation state and increases protein phosphatase 2A activity in the stalk-median eminence on proestrous afternoon
    Bin Liu
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901 6523, USA
    J Endocrinol 204:209-19. 2010
    ..is associated with dephosphorylation of tyrosine hydroxylase (TH) and reduced TH activity in the stalk-median eminence (SME), which contributes to the proestrous prolactin surge in rats...
  18. ncbi Morphological evidence for direct interaction between kisspeptin and gonadotropin-releasing hormone neurons at the median eminence of the male goat: an immunoelectron microscopic study
    Shuichi Matsuyama
    Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Tsukuba, Japan
    Neuroendocrinology 94:323-32. 2011
    ..Kisspeptin-ir cell bodies and fibers in the arcuate nucleus (ARC) and median eminence (ME) were fewer in intact male goats compared with castrated animals...
  19. ncbi Paraventricular nucleus neurons producing neurotensin after lipopolysaccharide treatment project to the median eminence
    Elodie Loum-Ribot
    Laboratoire des Régulations Neuroendocriniennes, EA2972, Universite Bordeaux 1, Avenue des Facultes, 33405 Talence, France
    Brain Res 1030:294-6. 2004
    ..Combining in situ hybridization with a retrograde neuronal marker, we demonstrated that neurotensin-containing neurons in the paraventricular nucleus project to the median eminence.
  20. ncbi Glial-gonadotrophin hormone (GnRH) neurone interactions in the median eminence and the control of GnRH secretion
    S R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Neuroendocrinol 20:732-42. 2008
    ..The available evidence suggests that glial cells of the median eminence regulate GnRH secretion via two related mechanisms...
  21. pmc The hypothalamic median eminence and its role in reproductive aging
    Weiling Yin
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Ann N Y Acad Sci 1204:113-22. 2010
    The median eminence at the base of the hypothalamus serves as an interface between the neural and peripheral endocrine systems...
  22. ncbi Definitive evidence for the existence of morphological plasticity in the external zone of the median eminence during the rat estrous cycle: implication of neuro-glio-endothelial interactions in gonadotropin-releasing hormone release
    V Prevot
    INSERM U 422, IFR 22, Neuroendocrinologie et Physiopathologie Neuronale, Place de Verdun, Lille, France
    Neuroscience 94:809-19. 1999
    Despite intense investigation, the demonstration of morphological plasticity in the external zone of the median eminence concerning the gonadotropin-releasing hormone system has never been reported...
  23. ncbi Inhibition of metastin (kisspeptin-54)-GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats
    S Yamada
    Laboratory of Reproductive Science, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Endocrinology 148:2226-32. 2007
    ..Quantitative RT-PCR revealed that the KiSS-1 mRNA level was significantly lower in the arcuate nucleus (ARC)-median eminence region in lactating ovariectomized (OVX) and estrogen-treated OVX rats than in nonlactating controls...
  24. ncbi Melanin-concentrating hormone stimulates the release of luteinizing hormone-releasing hormone and gonadotropins in the female rat acting at both median eminence and pituitary levels
    S R Chiocchio
    Instituto de Neurobiologia, Buenos Aires 1414, Argentina
    Biol Reprod 64:1466-72. 2001
    The purpose of this study was to investigate whether melanin-concentrating hormone (MCH) acts directly on the median eminence and on the anterior pituitary of female rats regulating LHRH and gonadotropin release...
  25. ncbi Ultrastructural evidence of kisspeptin-gonadotrophin-releasing hormone (GnRH) interaction in the median eminence of female rats: implication of axo-axonal regulation of GnRH release
    Y Uenoyama
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    J Neuroendocrinol 23:863-70. 2011
    ..functional interaction between kisspeptin and gonadotrophin-releasing hormone (GnRH) neuronal elements at the median eminence in female rats to clarify a possibility that kisspeptin directly stimulates GnRH release at the nerve end...
  26. ncbi Cadmium exposure differentially modifies the circadian patterns of norepinephrine at the median eminence and plasma LH, FSH and testosterone levels
    A Lafuente
    Laboratorio de Toxicologia, Facultad de Ciencias, Universidad de Vigo, Campus de Orense, Las Lagunas, 32004 Orense, Spain
    Toxicol Lett 146:175-82. 2004
    ..work was designed to analyze the cadmium effects on time-of-day variations of norepinephrine (NE) content in median eminence and on plasma levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone in ..
  27. ncbi Variation of endothelial nitric oxide synthase synthesis in the median eminence during the rat estrous cycle: an additional argument for the implication of vascular blood vessel in the control of GnRH release
    C Knauf
    Institut National de la Santé et de la Recherche Médicale U422, Institut Fédératif de Recherches 22, Unité de Neuroendocrinologie et Physiopathologie Neuronale, 59045 Lille Cedex, France
    Endocrinology 142:4288-94. 2001
    Recent studies from our laboratory suggested that the vascular endothelium of the median eminence was involved via nitric oxide secretion in the modulation of GnRH release during the estrous cycle...
  28. ncbi Activation of erbB-1 signaling in tanycytes of the median eminence stimulates transforming growth factor beta1 release via prostaglandin E2 production and induces cell plasticity
    Vincent Prevot
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA
    J Neurosci 23:10622-32. 2003
    ..Earlier studies suggested that tanycytes, an ependymoglial cell type of the median eminence, regulate LHRH release during the estrous cycle by undergoing plastic changes that alternatively allow or ..
  29. pmc Gonadotrophin-releasing hormone nerve terminals, tanycytes and neurohaemal junction remodelling in the adult median eminence: functional consequences for reproduction and dynamic role of vascular endothelial cells
    V Prevot
    INSERM, Jean Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France
    J Neuroendocrinol 22:639-49. 2010
    ..areas within the hypothalamus are involved in the secretion of gonadotrophin-releasing hormone (GnRH), the median eminence of the hypothalamus, where the nerve terminals are located, plays a particularly critical role in the release ..
  30. pmc Role of estradiol in the dynamic control of tanycyte plasticity mediated by vascular endothelial cells in the median eminence
    Sandrine De Seranno
    Institut National de la Santé et de la Recherche Médicale Unité 837, Bâtiment, Biserte, Place de Verdun, 59045 Lille Cedex, France
    Endocrinology 151:1760-72. 2010
    ..In the median eminence of the hypothalamus, endothelial cells are key players in the plasticity of tanycytes (specialized astroglia) ..
  31. ncbi Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors
    Ornsiri Cheunsuang
    Department of Veterinary Anatomy, Chulalongkorn University, Bangkok, Thailand
    Glia 52:228-33. 2005
    ..several different dyes and markers are found to accumulate rapidly in cells in the arcuate nucleus and median eminence, and the capillaries in this region appear specialised for exchange of molecules...
  32. ncbi Neurochemistry and plasticity of the median eminence and neural pituitary lobe in relation to background adaptation of Xenopus laevis
    Diane C A W van Wijk
    Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, European Graduate School of Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands
    Ann N Y Acad Sci 1163:524-7. 2009
    ..but also mesotocin and met-enkephalin from both neurohemal areas in the pituitary neural lobe and in the median eminence. We also show that the external zone of the median eminence is plastic, depending in size on the state of ..
  33. ncbi Leptin stimulates growth hormone secretion via a direct pituitary effect combined with a decreased somatostatin tone in a median eminence-pituitary perifusion study
    Roberta Saleri
    Department of Animal Production, Veterinary Biotechnology, Food Safety, University of Parma, Parma, Italy
    Neuroendocrinology 79:221-8. 2004
    ..In some experiments, pituitary slices were coincubated with stalk median eminence (SME)...
  34. ncbi Regulation of gonadotropin releasing hormone release by neuropeptide Y at the median eminence during the preovulatory period in ewes
    J P Advis
    Department of Animal Sciences, Rutgers University, New Brunswick, NJ, USA
    Neuroendocrinology 77:246-57. 2003
    The median eminence (ME) of the hypothalamus is known to be an important brain site where hypophysiotropic release might be regulated by excitatory and inhibitory signals impinging on their neuronal terminals...
  35. ncbi Evidence for a spontaneous nitric oxide release from the rat median eminence: influence on gonadotropin-releasing hormone release
    C Knauf
    , , 59045 Lille Cedex, France
    Endocrinology 142:2343-50. 2001
    ..NO is secreted at the median eminence (ME), the common termination field for the antehypophysiotropic neurons, under the stimulation of other ..
  36. ncbi Deficiency of dopamine in the median eminence of Snell dwarf mice
    W W Morgan
    Endocrinology 109:2069-75. 1981
  37. ncbi T(3) implantation mimics photoperiodically reduced encasement of nerve terminals by glial processes in the median eminence of Japanese quail
    Takashi Yamamura
    Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, 464 8601, Nagoya, Japan
    Cell Tissue Res 324:175-9. 2006
    ..interaction between gonadotrophin-releasing hormone (GnRH) nerve terminals and glial endfeet in the median eminence (ME)...
  38. ncbi Ventromedial arcuate nucleus communicates peripheral metabolic information to the suprachiasmatic nucleus
    Chun Xia Yi
    Netherlands Institute for Brain Research, Meibergdreef 33, Amsterdam, The Netherlands
    Endocrinology 147:283-94. 2006
    ..Due to variation of injection sites, tracer was also injected into the subependymal layer of the median eminence (seME), which showed similar projection patterns as the vmARC...
  39. pmc Phosphorylation state of tyrosine hydroxylase in the stalk-median eminence is decreased by progesterone in cycling female rats
    Bin Liu
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6523, USA
    Endocrinology 149:1462-9. 2008
    ..study, we examined enzyme activity and phosphorylation state of tyrosine hydroxylase (TH) in the stalk-median eminence of cycling female rats on proestrus and estrus and related these to circulating progesterone levels...
  40. ncbi Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence
    Sally J Krajewski
    Department of Pathology, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    J Comp Neurol 489:372-86. 2005
    ..interweaving and close apposition of GnRH and proNKB-immunoreactive (ir) fibers was observed within the rat median eminence, where GnRH axons expressed NK3R immunoreactivity...
  41. ncbi Changes of prolactin regulatory mechanisms in aging: 24-h rhythms of serum prolactin and median eminence and adenohypophysial concentration of dopamine, serotonin, (gamma-aminobutyric acid, taurine and somatostatin in young and aged rats
    A I Esquifino
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid 28040, Spain
    Exp Gerontol 39:45-52. 2004
    Twenty-four hour rhythmicity of serum prolactin and median eminence and anterior pituitary content of dopamine (DA), serotonin (5HT), gamma-aminobutyric acid (GABA), taurine and somatostatin were examined in 2 months-old and 18-20 months-..
  42. ncbi Rhythmic variation in gamma-aminobutyric acid(A)-receptor subunit composition in the circadian system and median eminence of Syrian hamsters
    G Naum O
    , , Universidad Nacional de Quilmes, , B1876BXD Pcia. de Buenos Aires, Argentina
    Neurosci Lett 310:178-82. 2001
    ..beta1 and beta3 were characterized by Western blot analysis in the hamster suprachiasmatic nuclei, retina and median eminence. A nocturnal maximum in the level of GABA(A) receptor beta1 subunit at midday and midnight (12:00 and 00...
  43. ncbi Effects of chronic bromocriptine treatment on tyrosine hydroxylase (TH) mRNA expression, TH activity and median eminence dopamine concentrations in ageing rats
    P S MohanKumar
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, USA
    J Neuroendocrinol 13:261-9. 2001
    ..or exogenous prolactin was monitored by measuring tyrosine hydroxylase (TH) activity in the stalk median eminence of middle-aged cycling female rats (10-12 months), old constant oestrous rats (18-20 months) and old ..
  44. ncbi Estradiol coupling to endothelial nitric oxide stimulates gonadotropin-releasing hormone release from rat median eminence via a membrane receptor
    V Prevot
    INSERM, U 422, Unité de Neuroendocrinologie et Physiopathologie Neuronale, Lille, France
    Endocrinology 140:652-9. 1999
    The median eminence (ME), which is the common termination field for adenohypophysiotropic systems, has been shown to produce nitric oxide (NO), a signaling molecule involved in neuroendocrine secretion...
  45. ncbi Immunocytochemical evidence for growth hormone-releasing hormone in the tanycytes of the median eminence of the rat
    Jose Carretero
    Department of Human Anatomy and Histology, Faculty of Medicine, Laboratory of Neuroendocrinology, Institute of Neuroscience of Castilla y Leon, University of Salamanca, Spain
    Folia Morphol (Warsz) 61:209-16. 2002
    ..to analyse the potential existence and structure of a GHRH-transporting tuberoinfundibular system in the rat median eminence. The immunocytochemical analysis using anti-GHRH revealed an intense immunoreaction in the ependimary cells, ..
  46. ncbi Possible role of glutamate, aspartate, glutamine, GABA or taurine on cadmium toxicity on the hypothalamic pituitary axis activity in adult male rats
    A Lafuente
    Laboratorio de Toxicologia, Facultad de Ciencias, Universidad de Vigo, Las Lagunas, Orense, Spain
    Biometals 15:183-7. 2002
    ..The contents of glutamine, glutamate, aspartate, GABA and taurine in the median eminence, anterior, mediobasal and posterior hypothalamus, and in prefrontal cortex in adult male rats exposed to 272...
  47. ncbi Differential effects of colchicine on central dopaminergic neuronal activity and prolactin secretion in estrogen-primed ovariectomized rats
    Shu Chuan Yang
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Chin J Physiol 46:15-8. 2003
    ..b>Median eminence DOPAC levels exhibit a diurnal change between morning and afternoon as previously shown...
  48. ncbi Leptin regulates growth hormone-releasing factor, somatostatin, and alpha-melanocyte-stimulating hormone but not neuropeptide Y release in rat hypothalamus in vivo: relation with growth hormone secretion
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Tochigi 324 8501, Japan
    J Neurosci 22:6265-71. 2002
    ..Leptin was infused into the median eminence-arcuate nucleus complex at three different concentrations, i.e., 1.0 (normal feeding level), 3...
  49. ncbi Hypothalamic thyrotropin-releasing hormone mRNA responses to hypothyroxinemia induced by sleep deprivation
    Carol A Everson
    Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Endocrinol Metab 283:E85-93. 2002
    ....
  50. ncbi Physiological role of salsolinol: its hypophysiotrophic function in the regulation of pituitary prolactin secretion
    Béla E Tóth
    Neuroendocrine Research Laboratory, Department of Human Morphology and Developmental Biology, Semmelweis University, Tuzolto u 58, Budapest H 1094, Hungary
    Neurotoxicol Teratol 24:655-66. 2002
    ..Moreover, high affinity binding sites for SAL have been detected in areas, like median eminence (ME) and the neuro-intermediate lobe (NIL) that are known terminal fields of the tuberoinfundibular DAergic (..
  51. ncbi Opioid control of prolactin secretion in late pregnant rats is mediated by tuberoinfundibular dopamine neurons
    Zane B Andrews
    Department of Anatomy and Structural Biology and Neuroscience Research Centre, School of Medical Sciences, University of Otago, P O Box 913, Dunedin, New Zealand
    Neurosci Lett 328:60-4. 2002
    ..These data indicate that endogenous opioid neurons facilitate PRL secretion at the end of pregnancy by suppressing TIDA neuronal activity...
  52. ncbi Fasting stimulates tuberoinfundibular dopaminergic neuronal activity and inhibits prolactin secretion in oestrogen-primed ovariectomized rats: involvement of orexin A and neuropeptide Y
    Y C Hsueh
    Department of Physiology, School of Life Science, National Yang Ming University, Taipei, Taiwan
    J Neuroendocrinol 14:745-52. 2002
    ..by measuring concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) or 3,4-dihydroxyphenylalanine in the median eminence. i.c.v...
  53. ncbi Neuroendocrine plasticity in GnRH release during rat estrous cycle: correlation with molecular markers of synaptic remodeling
    Gurcharan Kaur
    Neurochemistry and Neuroendocrinology Laboratory, Department of Biotechnology, Guru Nanak Dev University, Amritsar 143005 Pb, India
    Brain Res 954:21-31. 2002
    ..in the gonadotropin releasing hormone (GnRH) neurons in the preoptic area (POA) and their terminals in the median eminence-arcuate (ME-ARC) region are reported to occur during ovarian cycle that may be involved in the GnRH release ..
  54. ncbi Estradiol affects axo-somatic contacts of neuroendocrine cells in the arcuate nucleus of adult rats
    A Parducz
    Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, 6701, Szeged, Hungary
    Neuroscience 117:791-4. 2003
    ..of the tracer Fluorogold we retrogradely labeled a subpopulation of arcuate neurons that project to the median eminence. We than applied the disector method for synapse quantification and found that these "hypophysiotropic ..
  55. pmc Leptin directly acts within the hypothalamus to stimulate gonadotropin-releasing hormone secretion in vivo in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Tochigi, Japan
    J Physiol 545:255-68. 2002
    ..was infused into the medial preoptic area (where the majority of GnRH neuronal cell bodies exist) or the median eminence-arcuate nucleus complex (where axon terminals of GnRH neurons are located)...
  56. ncbi Microarray analysis reveals interleukin-6 as a novel secretory product of the hypothalamo-neurohypophyseal system
    Mohamed T Ghorbel
    University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, United Kingdom
    J Biol Chem 278:19280-5. 2003
    ..stimulus resulted in an increase in IL-6 immunoreactivity in the axons of the internal zone of the median eminence and a marked reduction in IL-6-like material in the posterior pituitary gland...
  57. ncbi Distribution of fluorescence following injection of recombinant adeno-associated virus encoding green fluorescent protein into the paraventricular nucleus
    Helen Ward
    Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Campus, London, UK
    Neuroendocrinology 77:100-4. 2003
    ..a spread of enhanced green fluorescent protein from the paraventricular nucleus of the hypothalamus into the median eminence and neurohypophysis...
  58. ncbi Binding site of salsolinol: its properties in different regions of the brain and the pituitary gland of the rat
    Krisztián Gy Homicskó
    Neuroendocrine Research Laboratory, Department of Human Morphology and Developmental Biology, Semmelweis University, IX Tuzoltó u 58, Budapest H 1094, Hungary
    Neurochem Int 42:19-26. 2003
    ..Specific and saturable binding has been detected in the striatum, cortex, median eminence and in the hypothalamus as well as in the AL and the neuro-intermediate lobe (NIL) of the pituitary gland...
  59. ncbi Morphofunctional characteristics of the gastrin-releasing peptide-synthesizing system of the hypothalamus in normal conditions and in experimental diabetes in rats
    A V Abramov
    Department of Pathophysiology, Zaporozh e Medical University
    Neurosci Behav Physiol 32:567-72. 2002
  60. ncbi Developmental changes in gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica) hypothalamo-hypophysial system
    T Ubuka
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    J Endocrinol 178:311-8. 2003
    ..peptide was shown to be located in neurons of the paraventricular nucleus (PVN) and their terminals in the median eminence (ME), and to decrease gonadotropin release from cultured anterior pituitary in adult birds...
  61. ncbi Interleukin-6 and nitric oxide synthase expression in the vasopressin and corticotrophin-releasing factor systems of the rat hypothalamus
    Tomas Gonzalez-Hernandez
    Department of Anatomy, Pathology and Histology, Faculty of Medicine, University of La Laguna, 38207 La Laguna, Tenerife, Spain
    J Histochem Cytochem 54:427-41. 2006
    ..injection of colchicine, and the study in parallel of the labeling pattern of axons in the median eminence. Within AVP cells, we distinguished two different populations: large, intensely stained AVP cells ..
  62. ncbi Developmental changes of nitric oxide synthase expression in the rat hypothalamoneurohypophyseal system
    Qiuju Yuan
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Anat Rec A Discov Mol Cell Evol Biol 288:36-45. 2006
    ..neurons were not discernable in the supraoptic nucleus (SON), the paraventricular nucleus (PVN), and the median eminence (ME) at PN1 and PN7. A few neurons positive for nNOS were first detected at PN14...
  63. ncbi Distribution of somatostatin immunoreactive neurons and fibres in the central nervous system of a chondrostean, the Siberian sturgeon (Acipenser baeri)
    Fátima Adrio
    Department of Cell Biology and Ecology, Faculty of Biology, University of Santiago de Compostela, E 15782, Santiago de Compostela, Spain
    Brain Res 1209:92-104. 2008
    ..preoptic area and hypothalamus and abundant SOM-ir fibres coursed along the hypothalamic floor towards the median eminence, suggesting a hypophysiotrophic role for SOM in sturgeon...
  64. ncbi Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus
    Mario Perello
    Division of Endocrinology, Department of Medicine Brown University Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Endocrinology 147:2705-16. 2006
    ....
  65. ncbi Colocalisation of dynorphin a and neurokinin B immunoreactivity in the arcuate nucleus and median eminence of the sheep
    C D Foradori
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Neuroendocrinol 18:534-41. 2006
    ..nucleus, where they formed close appositions with DYN/NKB-positive neurones, and in the external zone of the median eminence. Taken together with previous findings, these data suggest that a subpopulation of arcuate nucleus neurones ..
  66. ncbi Role of androgens and glucocorticoids in the regulation of diazepam-binding inhibitor mRNA levels in male mouse hypothalamus
    V Compère
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, UA CNRS, University of Rouen, Mont Saint Aignan, France
    Brain Res 1119:50-7. 2006
    ..Cells expressing DBI mRNA were mostly observed in the arcuate nucleus, the median eminence and the ependyma bordering the third ventricle...
  67. ncbi Glutamatergic innervation of the hypothalamic median eminence and posterior pituitary of the rat
    E Hrabovszky
    Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P O BOX 67, 1450 Budapest, Hungary
    Neuroscience 144:1383-92. 2007
    ..The present studies were aimed to map the neuronal sources of VGLUT2 in the median eminence and the posterior pituitary, the main terminal fields of hypothalamic neurosecretory neurons...
  68. ncbi Dynorphin in pro-opiomelanocortin neurons of the hypothalamic arcuate nucleus
    N Maolood
    Department of Neuroscience, The Retzius Laboratory, Karolinska Institutet, Retzius vag 8, SE 171 77 Stockholm, Sweden
    Neuroscience 154:1121-31. 2008
    ..The results suggest a role for DYN in control of energy balance by mediating the effect of peripheral hormones such as leptin and insulin...
  69. ncbi Pituitary atrial natriuretic peptide of paraventricular nucleus origin
    Mariann Fodor
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest
    Ideggyogy Sz 60:94-6. 2007
    ..Meantime, increased levels of immunoreactive ANP were measured in the median eminence, due to the accumulation of the peptide in the transected axons centrally to the transected stalk and in the ..
  70. pmc Oxytocin action at the lactotroph is required for prolactin surges in cervically stimulated ovariectomized rats
    De nise T McKee
    Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
    Endocrinology 148:4649-57. 2007
    ....
  71. ncbi Colocalization of kisspeptin and gonadotropin-releasing hormone in the ovine brain
    S Pompolo
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Endocrinology 147:804-10. 2006
    ..kisspeptin and GnRH was also seen in varicose neuronal fibers within the external, neurosecretory zone of the median eminence. Apart from the kisspeptin/GnRH cells, a population of single-labeling kisspeptin-IR cells was also observed ..
  72. ncbi Hypothalamic projections to locus coeruleus neurons in rat brain
    Beverly A S Reyes
    Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, PA 19107, USA
    Eur J Neurosci 22:93-106. 2005
    ..Finally, dual retrograde tracing from the LC and median eminence revealed that PVN neurons that project to the LC are a population distinct from that projecting to the median ..
  73. ncbi Lack of involvement of dopamine and serotonin during the orphanin FQ/Nociceptin (OFQ/N)-induced prolactin secretory response
    Amy Kraska
    Department of Zoology, Center for Neuroscience, Miami University, Oxford, OH 45056, USA
    Life Sci 77:1465-79. 2005
    ..We investigated the involvement of the dopaminergic neurons by quantifying DOPAC:DA levels in the median eminence and neurointermediate lobe following central administration of OFQ/N to female Sprague-Dawley rats...
  74. ncbi Induction and temporal changes of osteopontin mRNA and protein in the brain following systemic lipopolysaccharide injection
    Jeong Sun Choi
    College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, 137 701 Seoul, South Korea
    J Neuroimmunol 141:65-73. 2003
    ..These results provide the first evidence of OPN induction in astrocytes and microglia following peripheral immune challenge, and suggest that OPN may play a key role in the pathogenesis of neuroinflammation...
  75. ncbi Ontogeny of the expression of catecholamine synthesising enzymes in the female porcine median eminence arcuate nucleus complex (MEARC)
    Waldemar Sienkiewicz
    Department of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland
    Folia Morphol (Warsz) 62:239-42. 2003
    The ontogeny of the catecholaminergic system of the median eminence (ME) arcuate nucleus (ARC) complex (MEARC) has been studied in various animal species but so far, nothing has been learnt about the development of catecholaminergic ..
  76. ncbi Delineation of responsive AVP-containing neurons to running stress in the hypothalamus
    Tsuyoshi Saito
    Laboratory of Exercise Biochemistry, Institute of Health and Sport Sciences, Tsukuba 305 8574, Ibaraki, Japan
    Am J Physiol Regul Integr Comp Physiol 286:R484-90. 2004
    ..prepared for immunocytochemistry for both AVP/Fos in the hypothalamus and enzyme immunoassay for the stalk median eminence (SME) AVP content...
  77. ncbi Decreased hypothalamic and adrenal angiotensin II receptor expression and adrenomedullary catecholamines in transgenic mice with impaired glucocorticoid receptor function
    Paul Jain
    Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuroendocrinology 80:171-80. 2004
    ..significantly less numbers of Ang II AT(1) receptors in the hypothalamic paraventricular nucleus and median eminence, lower numbers of AT(2) receptors in supraoptic and paraventricular nuclei and lower numbers of AT(2) ..
  78. ncbi The peripheral noradrenergic terminal as possible site of action of salsolinol as prolactoliberin
    D Székács
    Neuroendocrine Research Unit, Hungarian Academy of Sciences, Department of Human Morphology, Semmelweis University, Budapest, Hungary
    Neurochem Int 50:427-34. 2007
    ..p.). Salsolinol did not affect the in vitro release of dopamine (DA) in the median eminence, and did not inhibit the L-DOPA induced increase of DA level in the median eminence...
  79. ncbi Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats
    A Lafuente
    Laboratorio de Toxicologia, Facultad de Ciencias, Universidad de Vigo, Campus de Orense, Las Lagunas, 32004 Orense, Spain
    Toxicol Lett 155:87-96. 2005
    ..throughout a 24 h cycle to measure circulating prolactin levels and dopamine and serotonin content in the median eminence and in both anterior and posterior pituitary...
  80. ncbi Pharmacological characteristics of KP-102 (GHRP-2), a potent growth hormone-releasing peptide
    Naomi Doi
    Department of Pharmacology, Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Tokyo, Japan
    Arzneimittelforschung 54:857-67. 2004
    ..The GH-releasing activity of KP-102 was completely absent in hypophysectomized rats, but present in median eminence-lesioned rats in which secreted GH amounts were significantly less than those normal rats, indicating ..
  81. ncbi Salsolinol induces a decrease in cyclic AMP at the median eminence and an increase at the adenohypophysis in lactating rats
    Balazs Radnai
    Neuroendocrine Research Laboratory, Department of Human Morphology and Developmental Biology, Hungarian Academy of Sciences, Semmelweis University, Tuzolto u 58, Budapest, Hungary
    Brain Res Bull 65:105-10. 2005
    Investigating the cellular events in the pituitary gland, the intracellular cyclic AMP (cAMP) of the median eminence (ME), neuro-intermediate lobe (NIL) and the anterior lobe (AL) have been measured following 15-min of intravenous ..
  82. ncbi Distribution of corticotropin-releasing factor binding protein-immunoreactivity in the rat hypothalamus: association with corticotropin-releasing factor-, urocortin 1- and vimentin-immunoreactive fibres
    B A Henry
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Bristol, UK
    J Neuroendocrinol 17:135-44. 2005
    ..extending from the third ventricle were found in the mediobasal hypothalamus and within the arcuate nucleus-median eminence region...
  83. ncbi Coexistence of salusin and vasopressin in the rat hypothalamo-hypophyseal system
    Fumiko Takenoya
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neurosci Lett 385:110-3. 2005
    ..Many salusin-positive nerve fibers and their terminals were identified in the internal layer of the median eminence and posterior pituitary...
  84. ncbi Toxic effects of methoxychlor administered subcutaneously on the hypothalamic-pituitary-testicular axis in adult rats
    A Lafuente
    Laboratorio de Toxicologia, Facultad de Ciencias, Universidad de Vigo, Campus de Orense, Las Lagunas, Ourense, Spain
    Food Chem Toxicol 46:1570-5. 2008
    ..concentration an in serotoninergic metabolism in anterior, mediobasal and posterior hypothalamus and median eminence; (2) to evaluate effects induced by MTX exposure on gonadotropins and testosterone; 93 to elucidate whether ..
  85. ncbi Antibodies obtained by xenotransplantation of organ-cultured median eminence specifically recognize hypothalamic tanycytes
    Juan Luís Blázquez
    Departamento de Anatomia e Histologia Humanas, Facultad de Medicina, Universidad de Salamanca, Salamanca, Spain
    Cell Tissue Res 308:241-53. 2002
    ..After 30 days of organ culture, explants of bovine median eminence formed spherical structures mostly constituted by tanycytes...
  86. ncbi Distribution of androgen-binding protein in the rat hypothalamo-neurohypophyseal system, co-localization with oxytocin
    Zsofia Herbert
    Institut für Anatomie II, Friedrich Schiller Universitat Jena, Teichgraben 7, 07740, Jena, Germany
    Brain Res 992:151-8. 2003
    ..networks with varicosities, containing ABP immunofluorescence, were visible throughout the hypothalamus, the median eminence and in the posterior pituitary lobe...
  87. ncbi Involvement of central GABAergic neurons in basal and diurnal changes of tuberoinfundibular dopaminergic neuronal activity and prolactin secretion
    T Y Lee
    Department of Physiology, School of Life Science, National Yang-Ming University, Taipei, Taiwan, ROC
    Life Sci 68:1965-75. 2001
    ..activity were determined by measuring the concentration of 3,4-dihydroxyphenylacetic acid (DOPAC) in the median eminence (ME). Serum PRL level was determined by RIA...
  88. ncbi Double immunocytochemistry of vasoactive intestinal peptide and cGnRH-I in male quail: photoperiodic effects
    R Teruyama
    Department of Animal Science, University of Nebraska-Lincoln, Lincoln, NE 68583-0908, USA
    Cell Tissue Res 303:403-14. 2001
    ..Both VIP- and cGnRH-I-ir fibers heavily innervated the external layer of the median eminence (ME)...
  89. ncbi Central bombesin activates the hypothalamic-pituitary-adrenal axis. Effects on regional levels and release of corticotropin-releasing hormone and arginine-vasopressin
    P Kent
    School of Psychology, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada
    Neuroendocrinology 73:203-14. 2001
    ..ir-vasopressin (AVP) at the VMH, it elevated levels of this peptide in the hypothalamic paraventricular and median eminence/arcuate (Me/Arc) regions...
  90. ncbi TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion
    B J Lee
    Division of Neuroscience, Oregon Regional Primate Research Center Oregon Health Sciences University, Beaverton, Oregon 97006, USA
    Mol Cell Neurosci 17:107-26. 2001
    ..TTF-1 mRNA was also detected in astrocytes of the median eminence and ependymal/subependymal cells of the third ventricle, where it colocalized with erbB-2, a receptor ..
  91. ncbi Central stimulatory influence of oxytocin on preovulatory gonadotropin-releasing hormone requires more than the median eminence
    D Selvage
    Department of Pharmaceutical Sciences, School of Pharmacy and Allied Health Sciences, The University of Montana, Missoula, MT 50812-1552, USA
    Neuroendocrinology 74:129-34. 2001
    ..afternoon of proestrus (PE) in the cycling female rat is mediated at the level of GnRH terminals within the median eminence (ME), or at higher hypothalamic levels where GnRH cell bodies and axons are located...
  92. ncbi Alterations in hypothalamic insulin-like growth factor-I and its associations with gonadotropin releasing hormone neurones during reproductive development and ageing
    B H Miller
    Fishberg Research Center for Neurobiology, Kastor Neurobiology of Aging Laboratories, and Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neuroendocrinol 13:728-36. 2001
    ..IGF-I immunoreactivity was also high in the median eminence, the site of GnRH release, and GnRH neuroterminals were seen to interweave among IGF-I-immunopositive cells...
  93. ncbi Prostaglandins may participate in opioidergic and cholinergic control of the diurnal changes of tuberoinfundibular dopaminergic neuronal activity and serum prolactin level in ovariectomized, estrogen-treated rats
    Y C Chu
    Department of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    Brain Res Bull 56:61-5. 2001
    ..These data suggest that PG may be involved in opioidergic and cholinergic control of the diurnal changes of TIDA neuronal activity and the PRL secretion in ovariectomized (OVX) + E(2) rats...
  94. ncbi Neuronal organization of the melanin-concentrating hormone system in primitive actinopterygians: evolutionary changes leading to teleosts
    Bridget I Baker
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    J Comp Neurol 442:99-114. 2002
    ..polypteriformes, chondrosteans, holosteans, and teleosts, immunoreactive fibers were abundant in the median eminence or, in the case of teleosts, within the pars distalis itself, suggesting MCH acquired a hypophysial ..
  95. ncbi Effects of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion
    K Shieh
    Department of Physiology, School of Life Science, National Yang-Ming University, Taipei 11221, Taiwan
    Am J Physiol Regul Integr Comp Physiol 280:R705-12. 2001
    ..Intracerebroventricular administration of OFQ lowered DOPAC levels in the median eminence (ME), striatum, nucleus accumbens, and hypothalamic paraventricular nucleus in a dose (0...
  96. ncbi Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids
    M B Müller
    Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 141:4262-9. 2000
    ..nucleus of Crhr1-/- mutants together with a marked increase in AVP-like immunoreactivity in the median eminence. Administration of an AVP V1-receptor antagonist significantly decreased basal plasma ACTH levels in mutant ..
  97. ncbi Effect of precipitated morphine withdrawal on post-translational processing of prothyrotropin releasing hormone (proTRH) in the ventrolateral column of the midbrain periaqueductal gray
    Eduardo A Nillni
    Division of Endocrinology, Department of Medicine, Brown Medical School, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Neurochem 80:874-84. 2002
    ..changes were compared to other TRH-containing areas such as the hypothalamic paraventricular nucleus (PVN), median eminence (ME) and the lateral hypothalamus (LH)...
  98. ncbi Dissociation of prolactin secretion from tuberoinfundibular dopamine activity in late pregnant rats
    Z B Andrews
    Department of Anatomy and Structural Biology and Neuroscience Research Center, University of Otago School of Medical Sciences, Dunedin, New Zealand
    Endocrinology 142:2719-24. 2001
    ..TIDA neuronal activity were estimated using concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) in the median eminence as an index of dopamine metabolism...
  99. ncbi Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus
    S Diano
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endocrinology 139:2879-84. 1998
    ..layer and adjacent periventricular regions as well as in the arcuate nucleus and the external layer of the median eminence. Quantitative in situ hybridization analysis demonstrated that PTU treatment and short term fasting resulted ..
  100. ncbi The nitric oxide hypothesis of aging
    S M McCann
    Pennington Biomedical Research Center LSU, Baton Rouge 70808 4124, USA
    Exp Gerontol 33:813-26. 1998
    ..hormone neurons, and the arcuate nucleus, a region containing these neurons and axons bound for the median eminence. We are currently determining if LPS similarly activates cytokine and iNOS production in the cardiovascular ..
  101. pmc The control of reproductive physiology and behavior by gonadotropin-inhibitory hormone
    Takayoshi Ubuka
    Department of Integrative Biology and Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA 94720 3140, USA
    Integr Comp Biol 48:560-9. 2008
    ..GnIH neurons project to the median eminence, thus providing a functional neuroanatomical infrastructure to regulate anterior pituitary function...

Research Grants64

  1. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..Brain mast cells are abundant in the median eminence where they are juxtaposed to corticotropin-releasing hormone (CRH)-positive neurons and CRH is secreted under ..
  2. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2013
    ..cribriform plate, through the olfactory bulb and into the hypothalamus, finally extending their axons to the median eminence. This discrete population of ~800 neurons, scattered through the hypothalamus, controls puberty, menstrual ..
  3. Optical Study of Secretion in Mammalian Nerve Terminals
    BRIAN MATTHEW SALZBERG; Fiscal Year: 2013
    ..and paraventricular nuclei in the hypothalamus project their axons as bundles of fibers through the median eminence and infundibular stalk to arborize extensively and terminate in the neurohypophysis, a quasi-pure collection ..
  4. Tanycytes and Nonthyroidal Illness
    RONALD MICHAEL LECHAN; Fiscal Year: 2010
    ..and ventrolateral walls of the third ventricle between the rostral and caudal limits of the hypothalamic median eminence. Little is known about these cells but their expression of type 2 iodothyronine deiodinase (D2), an enzyme ..
  5. NEUROENDOCRINE CONTROL OF SEASONALITY
    Robert L Goodman; Fiscal Year: 2013
    ..for A15 inhibition of GnRH secretion in anestrus: 1) A15 neurons project directly to GnRH terminals in the median eminence, or 2) A15 neurons stimulate gonadotropin-inhibitory hormone (GnIH) neurons or inhibit a set of kisspeptin-..
  6. Role of Notch signaling in the Development and Guidance of Hypothalamic Neurons
    PAVEN AUJLA; Fiscal Year: 2013
    ..Hypothalamic neurons that project to the anterior lobe through the median eminence (ME), such as somatostatin (SS), are affected by both hypopituitarism and multiple anterior pituitary hormone ..
  7. NEUROTENSIN SYNTHESIS IN ARCUATE NEUROSECRETORY CELLS
    Mark Alexander; Fiscal Year: 1999
    ..levels of NT and neuromedin N will be measured to determine whether estrogen alters their ratio in the median eminence or neurointermediate lobe...
  8. BRAIN GENES GOVERNING REPRODUCTION
    Robert Steiner; Fiscal Year: 2005
    ..GALP is only expressed in the arcuate nucleus and median eminence of the hypothalamus, which are nodal points for integration of metabolism and reproduction...
  9. Hypothalamic Type 2 Deiodinase in Metabolism Regulation
    Sabrina Diano; Fiscal Year: 2005
    ..In the adult rat brain, high DII activity is present in the arcuate nucleus/median eminence region with minimal activity in the paraventricular nucleus where the central thyroid-regulating neurons, the ..
  10. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    SARAH LEIBOWITZ; Fiscal Year: 2004
    ..it is hypothesized that: a) GAL, in specific neurons of the paraventricular nucleus (PVN) that project to the median eminence (ME), contributes to increased body weight gain and adiposity in response to a high-fat diet; and b) NPY, in ..
  11. Neuroendocrinology of Galanin-Like Peptide
    Robert Steiner; Fiscal Year: 2006
    ..of GALP mRNA in the brain is limited to a cluster of neurons in the hypothalamic arcuate nucleus and the median eminence. We have recently discovered that GALP neurons are direct targets for the adipocyte-derived hormone leptin...
  12. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD LECHAN; Fiscal Year: 2007
    ..has a dual inhibitory effect on TRH neurons as a result of inducing morphologic rearrangement of tanycyte endfeet processes in association with TRH-containing axon terminals in the external zone of the median eminence.
  13. A NEUROENDOCRINOLOGICAL STUDY OF THE HIPPOCAMPUS
    Alberto Carrillo; Fiscal Year: 1980
    ..DA), serotonin (5-HT) and acetylcholine (ACH) in the medial preoptic area (MPOA), arcuate nucleus (ARC) and median eminence (ME) as well as plasma LH levels on the day of proestrus...
  14. D2 TANTYCYTES IN THE REGULATION OF HPT AXIS
    RONALD LECHAN; Fiscal Year: 2001
    ..D2 mRNA will be used to infect tanycytes after stereotaxic injection of the virus into the third ventricle or median eminence. The second model will involve the development of transgenic mice, using the DARPP-32 gene as a tool to ..
  15. NEUROENDOCRINE BASIS OF SEASONAL BREEDING
    Michael Lehman; Fiscal Year: 1991
    ..interpretation of seasonal plasticity in the LHRH system is a knowledge of which LHRH cells project to the median eminence, and thereby constitute the pulse generator...
  16. HYPOTHALAMIC CONTROL OF PROLACTIN SECRETION
    JAMES VOOGT; Fiscal Year: 2001
    ..pathways play in PRL regulation, these are likely candidates thaat relay expression of the clock to the median eminence and pituitary to drive PRL surges...
  17. AGING LHRH SYSTEM/EM IMMUNOCYTOCHEMICAL STUDIES
    JOAN WITKIN; Fiscal Year: 1992
    ..in the preoptic area (POA) and their axons and terminal fields in the medial basal hypothalamus (MBH) and median eminence (ME) in the male rat, using adult (2-4 mos), middle aged (10-12 mos) and old (22-24 mos) animals...
  18. GNRH DEFICIENCY --CORRECTION BY PREOPTIC AREA GRAFTS
    MARIE GIBSON; Fiscal Year: 1999
    ..This phenomonon depends upon the capacity of these implanted neurons to send axons to the median eminence and on their integration into appropriate host neural circuits...
  19. ALCOHOL & BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESIS
    Feng Zhou; Fiscal Year: 2003
    ..quantitative morphometric analysis of associated midline structures such as the septum, subcommissural organ, median eminence, ventricles, and midline brainstem...
  20. BIOGENIC AMINE LEVELS IN VIVO AND PITUITARY FUNCTION
    JAMES VOOGT; Fiscal Year: 1980
    ..The primary brain areas to be studied include the arcuate-median eminence area, The preoptic area and the caudate nucleus...
  21. Otx2 in the development & regulation of the GnRH neuron
    Andrew Wolfe; Fiscal Year: 2002
    ..in the murine brain consists of scattered neurons from the olfactory bulbs to the rostral aspect of the median eminence with the highest concentration of GnRH neurons located at the level of the OVLT and the POA...
  22. Endocrine Role of OFQ/N: Studies with Knock-out Mice
    Phyllis Callahan; Fiscal Year: 2002
    ..neural mechanism of action will be determined by quantifying specific amines, particularly dopamine, in the median eminence and other select regions of the brain...
  23. NEUROENDOCRINE EFFECTS OF PERINATAL OPIATE EXPOSURE
    JAMES VOOGT; Fiscal Year: 1992
    ..in the nerve terminals will be measured by in vitro accumulation of L-dihydroxyphenylalanine in the stalk-median eminence and 5-hydroxytryptophan in the medial basal hypothalamus after incubation with a decarboxylase inhibitor...
  24. HYPOPHYSIOTROPIC NEURON DIFFERENTIATION--TARGET FEEDBACK
    David Hurley; Fiscal Year: 2006
    ..1) the extent to which hypophysiotropic axons terminate aberrantly outside of or within the hypothalamic median eminence (ME) and whether this pattern is regressive, using anterograde and retrograde tract tracing, ..
  25. ROLE OF HORMONES IN THE PROCESSING OF NEURONAL PEPTIDES
    Ayalla Barnea; Fiscal Year: 1992
    ..S.A.1 is to elucidate the mechanism(s) by which Cu modulates LHRH release; using explants of the median eminence as a model...
  26. NEUROENDOCRINE REGULATION OF EPISODIC LH RELEASE
    Robert Gallo; Fiscal Year: 1990
    ..effect of P is exerted at least in part via the EOPs, and whether the medial preoptic area or arcuate-median eminence regions are neural loci involved in P-dependent, EOP suppression of LH pulse frequency, as well as ..
  27. Regulation of GnRH Neuronal Development by FGF Signaling
    John Gill; Fiscal Year: 2005
    ..From the nose, GnRH neurons migrate into the brain and target their axons to the median eminence of the hypothalamus for GnRH release...
  28. FORMS OF GONADOTROPIN-RELEASING HORMONE
    HENRYK URBANSKI; Fiscal Year: 2000
    ..Dil and Fluoro-Gold tracing to determine which of the novel GnRH neuronal sub-populations send axons to the median eminence and, by inference, contribute to the neuroendocrine control of the reproductive axis; (2) Use in situ ..
  29. ULTRASTRUCTURAL STUDIES OF DEVELOPING INFUNDIBULUM
    Barbara Monroe; Fiscal Year: 1980
    ..METHODS: Tissues of the developing infundibulum (median eminence and infundibular stem) will be studied in a twofold approach: 1) Human fetuses will be used for electron ..
  30. GONADOTROPIN RELEASING HORMONE DYNAMICS AND BEHAVIOR
    David Albertini; Fiscal Year: 1980
    ..area which may influence behavior as well as the release of gonadotropic hromones in the arcuate-median eminence region...
  31. Mechanisms of Neuronal Regulation by Leptin and Insulin
    Michael Cowley; Fiscal Year: 2007
    ..These signals reach the neurons because of a leaky blood brain barrier at the median eminence. In obesity, it appears that leptin no longer regulates the melanocortin system...
  32. BLOOD FLOW AND ENERGY METABOLISM IN THE NEUROHYPOPHYSIS
    ROBERT BRYAN; Fiscal Year: 1992
    ..example, factors which regulate the synthesis and release of adenohypophyseal hormones are secretes by the median eminence and transported to the adenohypophysis by blood...
  33. IMMUNOTECHNIQUES FOR GNRH AND RELATED NEUROPEPTIDES
    GERALD KOZLOWSKI; Fiscal Year: 1980
    ..implicated to be modulating substances for release of GnRH will be visualized in the hypothalamus and median eminence of rats and mice...
  34. AGING OF THE NEUROENDOCRINE HYPOTHALAMUS
    Ei Terasawa; Fiscal Year: 2000
    ..In the first Aim, we will determine the release pattern of GH, GHRH, and SS in the stalk-median eminence (S-ME) of the aged and young female monkeys using a push-pull perfusion method, and will test the hypothesis ..
  35. HYPOTHALAMIC-HIPPOCAMPAL ELECTROPHYSIOLOGY
    Barry Layton; Fiscal Year: 1980
    ..e. neurons with median eminence axon terminals that function to regulate anterior pituitary secretion...
  36. HYPOTHALAMIC NEURONS BY BEHAVIORAL STRESS
    Ann Judith Silverman; Fiscal Year: 1991
    ..To determine if the stress-induced changes occur in neurosecretory cells afferent to the median eminence (ME), retrograde tracing from the ME will be combined with ICC...
  37. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010
    ..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..
  38. Orexinergic Pathways in Central Autonomic Control
    WILLIS SAMSON; Fiscal Year: 2005
    ..abstract_text> ..
  39. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2008
    ..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..
  40. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
    ..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
  41. Fifth International Melanocortin Meeting
    ROGER CONE; Fiscal Year: 2002
    ..To facilitate the gathering of a large international audience, funds are specifically requested to cover travel expenses for 17 speakers. ..
  42. Prolactin Feedback to Hypothalamic Dopaminergic Neurons
    LYDIA ARBOGAST; Fiscal Year: 2009
    ..Critical new information on prolactin's actions within the central nervous system should result from the proposed experiments. ..
  43. Restricted Sleep: Modification of adiposity and adipose tissue composition
    CAROL EVERSON; Fiscal Year: 2009
    ....
  44. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    Sarah F Leibowitz; Fiscal Year: 2010
    ..In summary, this grant tests the novel hypothesis that a high-fat diet itself can promote overeating and ultimately dietary obesity through a positive feedback loop involving circulating lipids, hypothalamic peptides and accumbens DA. ..
  45. Effects of Chronic Estrogen on TIDA Neurons: Role of Cytokines and NO
    Puliyur S MohanKumar; Fiscal Year: 2010
    ..Prolonged exposure to estrogen and elevated levels of PRL may promote the risk for breast cancer. ..
  46. COCAINE AND BRAIN DEVELOPMENT
    Pradeep G Bhide; Fiscal Year: 2010
    ..The proposed studies promise novel insights into the mechanism of cocaine's action on fetal brain development by examining the link between cocaine, dopamine and development of GABA circuits. ..
  47. Understanding Neurodevelopment in Macaques with Different Rearing Experiences
    Mar Sanchez; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  48. Opioid-Dopamine Interactions During Lactation
    LYDIA ARBOGAST; Fiscal Year: 2009
    ..Overall these studies will contribute to our understanding of the complex neuronal pathways involved in maintaining lactation. ..
  49. Differential regulation of kisspeptin, dynorphin, and NKB in the same neurons
    Robert Goodman; Fiscal Year: 2007
    ..Thus, these studies may provide information important for the development of better treatments of these pathological disruptions of reproductive function. [unreadable] [unreadable] [unreadable]..
  50. NEUROENDOCRINE ABNORMALITIES INDUCED BY SLEEP DEPRIVATIO
    CAROL EVERSON; Fiscal Year: 2001
    ..studies will determine whether TRH mRNA expression in the paraventricular nucleus and TRH content in the median eminence are suppressed and unresponsive to low T4, indicating impaired thyroid hormone regulation at the level of the ..
  51. BRAIN MONOAMINES AND LUTEINIZING HORMONE SECRETION
    William Crowley; Fiscal Year: 2003
    ..abstract_text> ..
  52. OXYTOCIN, VASOPRESSIN AND DEVELOPMENT OF SOCIAL BEHAVIOR
    Mar Sanchez; Fiscal Year: 2003
    ....
  53. WORKSHOP/USE OF NONHUMAN PRIMATES/NEUROSCIENCE RESEARCH
    Sergio Ojeda; Fiscal Year: 2002
    ....
  54. BRAIN CELL DEATH IN MRL MICE: TARGETS AND MECHANISMS
    Boris Sakic; Fiscal Year: 2004
    ..abstract_text> ..
  55. ProTRH sorting to the regulated secretory pathway
    EDUARDO NILLNI; Fiscal Year: 2006
    ..The sorting of the proTRH N- and C-terminal fragments is routed to two different pathways. Aim 4. The tertiary structure of proTRH contributes to its processing by PC1 and PC2 and further sorting to the RSP. ..
  56. TRH and Energy Homeostasis
    RONALD LECHAN; Fiscal Year: 2006
    ..abstract_text> ..
  57. A role for dopamine in brain development
    Pradeep Bhide; Fiscal Year: 2007
    ..It is also an excellent model to mimic dopamine imbalance in the CNS that can be produced by therapeutic drugs that intentionally or unintentionally target the dopaminergic system of the developing brain. ..
  58. Role of CREB function in the BNST in fear and anxiety-like behaviors
    Edward Meloni; Fiscal Year: 2007
    ..Such studies may ultimately lead to the development of novel and effective treatments for human anxiety disorders [unreadable] [unreadable]..
  59. RESEARCH TRAINING IN COMPARATIVE MEDICINE AND PATHOLOGY
    PULIYUR MOHANKUMAR; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  60. REPRODUCTIVE AGING AND THE HUMAN HYPOTHALAMUS
    Naomi Rance; Fiscal Year: 2007
    ..Our studies provide an exceptional opportunity to address basic biological issues directly relevant to the physiology of postmenopausal women. [unreadable] [unreadable] [unreadable]..
  61. LEPTIN ACTION ON HYPOTHALAMIC PEPTIDES GOVERNING FEEDING
    Abhiram Sahu; Fiscal Year: 2001
    ..These studies will further our understanding of leptin signaling in the hypothalamus in relation to feeding, and therefore will be relevant to the development of therapeutic approaches to eating disorders. ..