hypothalamo hypophyseal system

Summary

Summary: A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.

Top Publications

  1. ncbi Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
    Constantine Tsigos
    Hellenic National Diabetes Center, Athens, Greece
    J Psychosom Res 53:865-71. 2002
  2. ncbi Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
    P W Gold
    Clinical Neuroendocrinology Branch, Intramural Research Program, NIMH NIH, NIH Clinical Center, Room 2D 46 1284, Bethesda, MD 20892 1284, USA
    Mol Psychiatry 7:254-75. 2002
  3. ncbi Risky families: family social environments and the mental and physical health of offspring
    Rena L Repetti
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Psychol Bull 128:330-66. 2002
  4. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
  5. pmc Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
  6. ncbi Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge
    Brigitte M Kudielka
    Jacobs Center on Lifelong Learning and Institutional Development, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
    Psychoneuroendocrinology 34:2-18. 2009
  7. ncbi Genetic factors, perceived chronic stress, and the free cortisol response to awakening
    S Wust
    Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstrasse 10 11, 54290, Trier, Germany
    Psychoneuroendocrinology 25:707-20. 2000
  8. ncbi Is the cortisol awakening rise a response to awakening?
    Ines Wilhelm
    Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 32:358-66. 2007
  9. ncbi Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals
    Antonio Armario
    Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Neurosci Biobehav Rev 32:1121-35. 2008
  10. ncbi Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
    Neuroscience 119:887-97. 2003

Research Grants

  1. MECHANISMS GOVERNING INITIATION OF OVULATION
    Douglas Foster; Fiscal Year: 1980
  2. DST and Suicide Prediction
    Elizabeth Young; Fiscal Year: 2003
  3. HPA Axis in Depression and Anxiety
    Elizabeth Young; Fiscal Year: 2005
  4. BIOLOGY OF COMORBID DEPRESSION AND ANXIETY
    Elizabeth Young; Fiscal Year: 2001
  5. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
  6. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
  7. Neuronal Risk Markers for Nicotine Dependence in Youth
    Uma Rao; Fiscal Year: 2010
  8. Risk for Substance Abuse in Depressed Adolescents
    Uma Rao; Fiscal Year: 2006
  9. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
  10. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007

Detail Information

Publications264 found, 100 shown here

  1. ncbi Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
    Constantine Tsigos
    Hellenic National Diabetes Center, Athens, Greece
    J Psychosom Res 53:865-71. 2002
    ....
  2. ncbi Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
    P W Gold
    Clinical Neuroendocrinology Branch, Intramural Research Program, NIMH NIH, NIH Clinical Center, Room 2D 46 1284, Bethesda, MD 20892 1284, USA
    Mol Psychiatry 7:254-75. 2002
    ....
  3. ncbi Risky families: family social environments and the mental and physical health of offspring
    Rena L Repetti
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Psychol Bull 128:330-66. 2002
    ..We conclude that childhood family environments represent vital links for understanding mental and physical health across the life span...
  4. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
    ..Further elucidation of the biochemical and molecular mechanisms involved in GR changes in major depression is an exciting frontier that will no doubt lead to new insights into the pathophysiology and treatment of affective disorders...
  5. pmc Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
    ..These mechanisms, determined in rats, may explain some of the epidemic of obesity occurring in our society...
  6. ncbi Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge
    Brigitte M Kudielka
    Jacobs Center on Lifelong Learning and Institutional Development, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
    Psychoneuroendocrinology 34:2-18. 2009
    ....
  7. ncbi Genetic factors, perceived chronic stress, and the free cortisol response to awakening
    S Wust
    Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstrasse 10 11, 54290, Trier, Germany
    Psychoneuroendocrinology 25:707-20. 2000
    ..In line with several recent studies, the present findings further support the view that the cortisol awakening responses is consistently enhanced under chronic stress conditions...
  8. ncbi Is the cortisol awakening rise a response to awakening?
    Ines Wilhelm
    Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 32:358-66. 2007
    ..Although the cortisol awakening response is modulated by circadian influences, it primarily reflects phasic psychophysiological processes specific to the sleep-wake transition...
  9. ncbi Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals
    Antonio Armario
    Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Neurosci Biobehav Rev 32:1121-35. 2008
    ..This is particularly critical when trying to model post-traumatic stress disorders (PTSD), which demands a great effort to validate such putative models...
  10. ncbi Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
    Neuroscience 119:887-97. 2003
    ....
  11. ncbi Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration
    James P Herman
    Department of Psychiatry, University of Cincinnati, Psychiatry North, Bldg 43, UC E, 2nd Fl, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
    Ann N Y Acad Sci 1018:35-45. 2004
    ..As such, these neurons are positioned to summate limbic inputs into net inhibitory tone on the PVN and may thus play a major role in HPA dysfunction seen in affective disease states and aging...
  12. ncbi Corticosteroid insufficiency in acutely ill patients
    Mark S Cooper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    N Engl J Med 348:727-34. 2003
  13. ncbi Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats
    Greg M Anderson
    Department of Anatomy and Structural Biology, Centre for Neuroendocrinology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    Endocrinology 150:1834-40. 2009
    ..This effect may include actions of RFRP-3 on GnRH neurons and/or their anteroventral periventricular afferent inputs but is unlikely to involve direct inhibition of LH secretion at the level of the gonadotrope...
  14. ncbi Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening
    Marita Pruessner
    Douglas Hospital Research Center, McGill University, and McConnell Brain Imaging Centre, Montreal Neurological Hospital, McGill University, Montreal, Canada
    Psychosom Med 65:92-9. 2003
    ..The goal of the present study was to investigate the association of self-reported depressive symptomatology with early morning free cortisol levels and their relationship to measures of stress...
  15. pmc Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats
    Elizabeth D Kirby
    Helen Wills Neuroscience Institute, University of California Berkeley, 3060 VLSB 3140, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:11324-9. 2009
    ....
  16. pmc Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression
    Nicholas Barden
    Neuroscience Research Department, Centre Hospitalier de l Université Laval Research Centre, Sainte Foy, QC
    J Psychiatry Neurosci 29:185-93. 2004
    ..This new insight into antidepressant drug action suggests a novel approach to the development of antidepressant drugs...
  17. ncbi Developmental changes in gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica) hypothalamo-hypophysial system
    T Ubuka
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    J Endocrinol 178:311-8. 2003
    ..These results suggest that GnIH begins its function around hatch and acts as a hypothalamic factor to regulate gonadotropin release in the bird...
  18. ncbi Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease?
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042, Germany
    J Neuroimmunol 126:116-25. 2002
    ..It is discussed how the uncoupling of the two anti-inflammatory stress axes can appear...
  19. ncbi Hypothalamic-pituitary-adrenal axis impairment in the pathogenesis of rheumatoid arthritis and polymyalgia rheumatica
    M Cutolo
    University of Genova, Genova, Italy
    J Endocrinol Invest 25:19-23. 2002
    ..Given its multifaceted properties, including the ability to counteract the negative side effects of glucocorticoids, the therapeutical administration of DHEA might be considered in these pathologies, provided its safety is proved...
  20. ncbi Synthesis, transport, and release of posterior pituitary hormones
    M J Brownstein
    Science 207:373-8. 1980
    ..The precursors seem to be processed into smaller, biologically active molecules while they are being transported along the axon...
  21. pmc Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior
    Maureen P Boyle
    Department of Pediatrics, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:473-8. 2005
    ....
  22. ncbi Increased corticosterone pulse frequency during adjuvant-induced arthritis and its relationship to alterations in stress responsiveness
    R J Windle
    Department of Medicine, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    J Neuroendocrinol 13:905-11. 2001
    ..v. lipopolysaccharide. Thus, altered basal pulse frequency is a major factor influencing HPA activation during acute psychological stress...
  23. ncbi Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesis
    Simone Macri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, National Institute of Health ISS, Viale Regina Elena 299, 00161 Rome, Italy
    Horm Behav 50:667-80. 2006
    ....
  24. ncbi Sex differences in HPA axis responses to stress: a review
    Brigitte M Kudielka
    Department of Clinical and Theoretical Psychobiology, University of Trier, Johanniterufer 15, D 54290 Trier, Germany
    Biol Psychol 69:113-32. 2005
  25. ncbi Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7178, USA
    Psychopharmacology (Berl) 186:293-301. 2006
    ..However, little data are available for male nonhuman primates...
  26. ncbi Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences and the Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Psychiatry 160:1342-5. 2003
    ..The authors assessed the relationship between the hypothalamic-pituitary-adrenal (HPA) axis response to interferon-alpha (IFN-alpha) and the development of major depression during IFN-alpha treatment...
  27. ncbi The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent
    Ilona S Federenko
    Department of Clinical and Theoretical Psychobiology, University of Trier, Germany
    J Clin Endocrinol Metab 89:6244-50. 2004
    ..These findings challenge previous reports on a low heritability of markers of stimulated hypothalamus pituitary adrenal axis activity and are the first to document the relevance of context for psychoendocrine heritability estimates...
  28. ncbi Glucocorticoid receptor function in vitro in patients with major depression
    Carmine M Pariante
    Stress, Psychiatry and Immunology Laboratory, Section of Clinical Neuropharmacology, Division of Psychological Medicine, Institute of Psychiatry, King s College London, Denmark Hill, UK
    Stress 7:209-19. 2004
    ....
  29. ncbi Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
    T C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Mol Psychiatry 11:1003-15. 2006
    ..We could show that SNP rs4291 influences ACE activity and HPA-axis hyperactivity and might therefore represent a common pathophysiologic link for unipolar depression and cardiovascular disease...
  30. ncbi Evidence for altered hypothalamus-pituitary-adrenal axis functioning in systemic hypertension: blunted cortisol response to awakening and lower negative feedback sensitivity
    Petra H Wirtz
    Department of Clinical Psychology and Psychotherapy, Psychological Institute, University of Zurich, Binzmuhlestrasse 14 Box 26, CH 8050 Zurich, Switzerland
    Psychoneuroendocrinology 32:430-6. 2007
    ..We explored HPA axis activity and feedback sensitivity to oral administration of dexamethasone in systemic hypertension via assessment of the cortisol awakening response (CAR) and the circadian cortisol profile...
  31. ncbi Dissociable effects of isolation rearing and environmental enrichment on exploration, spatial learning and HPA activity in adult rats
    Nicole C A Schrijver
    Institute of Animal Sciences, Physiology and Animal Husbandry, ETH Zurich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland
    Pharmacol Biochem Behav 73:209-24. 2002
    ....
  32. ncbi Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice
    H J Harris
    Molecular Endocrinology, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, United Kingdom
    Endocrinology 142:114-20. 2001
    ..Thus 11beta-HSD-1 amplifies glucocorticoid feedback on the HPA axis and is an important regulator of neuronal glucocorticoid exposure under both basal and stress conditions in vivo...
  33. ncbi Hypothalamic-pituitary-adrenal axis function and prolactin secretion in systemic lupus erythematosus
    M A Gutierrez
    Department of Clinical Immunology and Rheumatology, Pontificia Universidad Catolica de Chile, Santiago
    Lupus 7:404-8. 1998
    ..02) and 0-90 min (P = 0.01) after TRH injection. These findings suggest that active SLE is associated with some degree of dysfunction of the hypothalamic-pituitary-glucocorticoid axis and PRL secretion...
  34. ncbi Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges
    B Klimes-Dougan
    Department of Psychology, The Catholic University of America, Washington DC 20064, USA
    Dev Psychopathol 13:695-719. 2001
    ..These and other results suggest that gender is an important moderating factor linking psychopathology. development, and context with HPA axis functioning in adolescence...
  35. ncbi Intact adrenocorticotropic hormone secretion but impaired cortisol response in patients with active rheumatoid arthritis. Effect of glucocorticoids
    B Gudbjornsson
    Department of Medicine, Uppsala University Hospital, Sweden
    J Rheumatol 23:596-602. 1996
    ..To study the hypothalamic-pituitary-adrenal axis in rheumatoid arthritis (RA) and the influence of glucocorticoid treatment...
  36. ncbi Sleep and the hypothalamo-pituitary-adrenocortical system
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Sleep Med Rev 6:125-38. 2002
    ..Some data suggest a major effect of light on cortisol secretion. Sleeping is widely associated with blunting and awakenings are linked with increases of HPA hormones...
  37. pmc Vasopressin: behavioral roles of an "original" neuropeptide
    Heather K Caldwell
    Section on Neural Gene Expression, NIMH, NIH, DHHS, Bethesda, MD 20892, United States
    Prog Neurobiol 84:1-24. 2008
    ..In this review, we concentrate on the scientific progress that has been made in understanding the role of Avp in regulating these and other behaviors across species. We also discuss the implications for human behavior...
  38. ncbi Neurochemical regulation of sleep
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:537-52. 2007
    ....
  39. pmc Neural regulation of endocrine and autonomic stress responses
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, Ohio 45237 0506, USA
    Nat Rev Neurosci 10:397-409. 2009
    ....
  40. ncbi Non-invasive stress-free application of glucocorticoid ligands in mice
    Sergiu Dalm
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    J Neurosci Methods 170:77-84. 2008
    ..In conclusion, the context-dependent and dose-controlled application of drugs via oats avoids confounding strong stress system activation and makes it suitable for studies on learning and memory processes...
  41. ncbi What stress does to your brain: a review of neuroimaging studies
    Katarina Dedovic
    Student, Douglas Mental Health University Institute, Verdun, Quebec
    Can J Psychiatry 54:6-15. 2009
    ..The goal of this review is to, first, summarize results from these studies from a perspective of task design and, second, assess the appropriateness of the different stress tasks used...
  42. ncbi Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
    T Kishimoto
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Nat Genet 24:415-9. 2000
    ..Both respond with increased edema formation in response to thermal exposure, however, indicating that in contrast to its central role in anxiety, the peripheral role of Crhr2 in vascular permeability is independent of gender...
  43. pmc Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
    Marni N Silverman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, Georgia 30322, USA
    Viral Immunol 18:41-78. 2005
    ....
  44. ncbi The neurobiology of stress: from serendipity to clinical relevance
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, Box 165, 10021, New York, NY, USA
    Brain Res 886:172-189. 2000
    ..Stress-induced structural changes in brain regions such as the hippocampus have clinical ramifications for disorders such as depression, post-traumatic stress disorder and individual differences in the aging process...
  45. ncbi Sex, aggression and impulse control: an integrative account
    Daniel Strüber
    Brain Research Institute, University of Bremen, Bremen, Germany
    Neurocase 14:93-121. 2008
    ..A model is proposed that relates impulse control and its neurobiological correlates to sex differences in direct aggression...
  46. ncbi Innovative approaches for the treatment of depression: targeting the HPA axis
    Fiona Thomson
    Department of Molecular Pharmacology, Organon Laboratories Ltd, Newhouse, Lanarkshire, ML1 5SH, UK
    Neurochem Res 33:691-707. 2008
    ..Agents that intervene with the mechanisms involved in (dys)regulation of cortisol synthesis and release are under investigation as possible therapeutic agents. The current status of some of these approaches is described in this review...
  47. ncbi Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stress
    S Ma
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Neuroendocrinol 17:22-8. 2005
    ....
  48. ncbi Vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation
    G Aguilera
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bldg 10, Rm 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892 1862, USA
    Regul Pept 96:23-9. 2000
    ..The data suggest that vasopressinergic regulation of the HPA axis is critical for sustaining corticotroph responsiveness in the presence of high circulating glucocorticoid levels during chronic stress...
  49. ncbi Stress and the female reproductive system
    S N Kalantaridou
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Ioannina, School of Medicine, Panepistimiou Avenue, 45500 Ioannina, Greece
    J Reprod Immunol 62:61-8. 2004
    ..Postpartum, this hypercortisolism is followed by a transient adrenal suppression, which may explain the blues/depression and increased autoimmune phenomena observed during this period...
  50. ncbi Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 31:1019-25. 2006
    ....
  51. ncbi The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance
    Arie G Nieuwenhuizen
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Physiol Behav 94:169-77. 2008
    ..In the Western society, with chronically high ambient levels of stress and the availability of high caloric foods, this relationship may imply a risk for the development of (visceral) obesity and the metabolic syndrome...
  52. ncbi Growth hormone and prolactin response to apomorphine in bipolar and unipolar depression
    Heather McPherson
    Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    J Affect Disord 76:121-5. 2003
    ..This was investigated by measuring growth hormone (GH) or prolactin (PRL) response to apomorphine (APO), a dopamine receptor agonist, in patients with bipolar depression, unipolar depression and control subjects...
  53. pmc Modulation of stress responses: how we cope with excess glucocorticoids
    Mary F Dallman
    Department of Physiology, UCSF, San Francisco, CA 94143, USA
    Exp Neurol 206:179-82. 2007
  54. ncbi Cortisol pulsatility and its role in stress regulation and health
    Elizabeth A Young
    Department of Psychiatry, The University of Michigan, USA
    Front Neuroendocrinol 25:69-76. 2004
    ..In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease...
  55. ncbi Hypothalamo-pituitary-adrenal axis activity predicts disease progression in multiple sclerosis
    Stefan M Gold
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Neuroimmunol 165:186-91. 2005
    ..Furthermore, HPA axis activity correlated with progression ratings and cognitive impairment three years later. Tests of HPA axis activity may be useful biomarkers for disease progression in MS...
  56. ncbi Hypothalamic-pituitary-adrenocortical axis dysregulation in patients with major depression is influenced by the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 328:299-303. 2002
    ..The HPA axis stimulating properties of higher ACE and consecutively higher AT-II and/or lower substance P concentrations may be crucial factors for the HPA system hyperactivity during major depressive episodes...
  57. ncbi Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation
    Jens Gaab
    Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
    Psychosom Med 64:951-62. 2002
    ..Because the HPA axis is involved in the adaptive responses to stress and CFS patients experience a worsening of symptoms after physical and psychological stress, we tested HPA axis functioning with three centrally acting stress tests...
  58. ncbi Several daily measurements are necessary to reliably assess the cortisol rise after awakening: state- and trait components
    J Hellhammer
    Department of Psychobiology, University of Trier, D 54295 Trier, Germany
    Psychoneuroendocrinology 32:80-6. 2007
    ....
  59. ncbi Central administration of cocaine- and amphetamine-regulated transcript increases phosphorylation of cAMP response element binding protein in corticotropin-releasing hormone-producing neurons but not in prothyrotropin-releasing hormone-producing neurons i
    Sumit Sarkar
    Tupper Research Institute and Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Brain Res 999:181-92. 2004
    ....
  60. ncbi Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis
    James P Herman
    Department of Psychiatry, Psychiatry North, ML 0506 2170 East Galbraith Road, University of Cincinnati College of Medicine, OH 45237 0506, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1201-13. 2005
    ....
  61. ncbi The significance of glucocorticoid pulsatility
    Stafford L Lightman
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY
    Eur J Pharmacol 583:255-62. 2008
    ..This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor...
  62. ncbi Interactions of chronic lead exposure and intermittent stress: consequences for brain catecholamine systems and associated behaviors and HPA axis function
    Miriam B Virgolini
    Environmental and Occupational Health Sciences Institute, a Joint Institute of the Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, 08854, USA
    Toxicol Sci 87:469-82. 2005
    ....
  63. ncbi Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Endocrinology 145:5431-8. 2004
    ....
  64. ncbi Maternal care and the development of stress responses
    D D Francis
    Developmental Neuroendocrinology Laboratory Douglas Hospital Research Center Departments of Psychiatry and Neurology and Neurosurgery 6875 Boul LaSalle McGill University Montréal Canada H4H 1R3
    Curr Opin Neurobiol 9:128-34. 1999
    ....
  65. ncbi Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review
    Harald Jorn Schneider
    Neuroendocrinology Group, Max Planck Institute of Psychiatry, Munich, Germany
    JAMA 298:1429-38. 2007
    ..This sequela is a potentially serious but treatable complication of brain injury...
  66. ncbi The HPA and immune axes in stress: the involvement of the serotonergic system
    B E Leonard
    Pharmacology Department, National University of Ireland, Galway, Ireland
    Eur Psychiatry 20:S302-6. 2005
    ....
  67. ncbi Permanent alterations in stress responsivity in female offspring subjected to combined maternal lead exposure and/or stress
    M B Virgolini
    Environmental and Occupational Health Sciences Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Neurotoxicology 27:11-21. 2006
    ....
  68. ncbi Glucocorticoids, chronic stress, and obesity
    Mary F Dallman
    University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Prog Brain Res 153:75-105. 2006
    ..Finally, we briefly discuss the problems with this network that normally serves to aid in responses to chronic stress, in our current overindulged, and underexercised society...
  69. pmc Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
    B Czeh
    Division of Neurobiology, German Primate Center, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 98:12796-801. 2001
    ..These findings provide a cellular and neurochemical basis for evaluating antidepressant treatments with regard to possible reversal of structural changes in brain that have been reported in depressive disorders...
  70. ncbi When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Am J Psychiatry 160:1554-65. 2003
    ....
  71. ncbi The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care
    Nicole M Cameron
    McGill Program for the Study of Behavior, Genes and Environment, Department of Psychiatry, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, Montreal, Que, Canada H4H 1R3
    Neurosci Biobehav Rev 29:843-65. 2005
    ..Ultimately, we will need to contend with the reality that neural development, function and health are defined by social and economic influences...
  72. ncbi Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype 1
    Guo Xiang Liu
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Model Organism Research Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Neuropsychopharmacology 32:1531-9. 2007
    ..These results showed that the absence of GAT1 affects mental status through enhancing the GABAergic system, as well as modifying the serotonergic system and the hypothalamic-pituitary-adrenal (HPA) activity in mice...
  73. ncbi A single exposure to immobilization causes long-lasting pituitary-adrenal and behavioral sensitization to mild stressors
    Xavier Belda
    Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Horm Behav 54:654-61. 2008
    ..Long-term effects of IMO on the susceptibility to stress-induced endocrine and emotional disturbances may be relevant to the characterization of animal models of post-traumatic stress...
  74. ncbi Stressor specificity of central neuroendocrine responses: implications for stress-related disorders
    K Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    Endocr Rev 22:502-48. 2001
    ..The adaptive response reflects the activation of specific central circuits and is genetically and constitutionally programmed and constantly modulated by environmental factors...
  75. ncbi Pituitary-adrenal response to acute and repeated mild restraint, forced swim and change in environment stress in arginine vasopressin receptor 1b knockout mice
    L Q Stewart
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, University of Bristol, Bristol, UK
    J Neuroendocrinol 20:597-605. 2008
    ..Furthermore, the normal corticosterone response to repeated exposure to change in environment stress also requires the Avpr1b to drive HPA axis responsiveness...
  76. ncbi The hypothalamic-pituitary-adrenal axis of patients with severe sepsis: altered response to corticotropin-releasing hormone
    S Schroeder
    , , Bonn, Germany
    Crit Care Med 29:310-6. 2001
    ..In addition, the plasma cortisol response to a single CRH stimulation was impaired in nonsurvivors compared with survivors. Reduced responses to CRH stimulation may reflect a state of endocrinologic organ dysfunction in severe sepsis...
  77. ncbi Prenatal stress and risk for psychopathology: specific effects or induction of general susceptibility?
    Anja C Huizink
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, Utrecht, Netherlands
    Psychol Bull 130:115-42. 2004
    ..Therefore, the evidence supports the view that exposure to prenatal stress may result in a general susceptibility to psychopathology, rather than exerting a direct effect on a specific form of psychopathology...
  78. ncbi Neuropeptides and the hypothalamic-pituitary-adrenocortical (HPA) system: review of recent research strategies in depression
    M Hatzinger
    Psychiatric University Hospital, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    World J Biol Psychiatry 1:105-11. 2000
    ..In conclusion, research in neuroendocrinology provided new insights into the underlying pathophysiology of depression and, in consequence, may lead to the development of new therapeutic tools...
  79. ncbi Adrenal insufficiency in the critically ill: a new look at an old problem
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 122:1784-96. 2002
    ..HPA dysfunction is a common and underdiagnosed disorder in the critically ill. We review the risk factors, pathophysiology, diagnostic approach, and management of HPA dysfunction in the critically ill...
  80. ncbi Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axis
    María Inés Forray
    Department of Pharmacy, Faculty of Chemistry, Catholic University of Chile, Santiago, Chile
    Brain Res Brain Res Rev 47:145-60. 2004
    ....
  81. ncbi Cytokines and major depression
    Olga J G Schiepers
    Department of Psychiatry and Neuropsychology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 29:201-17. 2005
    ....
  82. ncbi Clinical and biological effects of mifepristone treatment for psychotic depression
    Benjamin H Flores
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305 5723, USA
    Neuropsychopharmacology 31:628-36. 2006
    ..These results suggest that short-term use of mifepristone may be effective in the treatment of PMD and may re-regulate the HPA axis. Additional blinded studies are warranted...
  83. ncbi The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropin
    Anthony P Coll
    Department of Medicine, Box 232, Addenbrooke s Hospital, Cambridge CB2 2QR, United Kingdom
    Endocrinology 145:4721-7. 2004
    ..Although such glands are atrophic and hypofunctional, exposure to ACTH alone can restore their size, morphology, and corticosterone secretion...
  84. ncbi Importance of studying the contributions of early adverse experience to neurobiological findings in depression
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 29:641-8. 2004
    ....
  85. ncbi Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue
    Alicia K Smith
    Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, 1600 Clifton Road, MSG41, Atlanta, GA 30333, USA
    Pharmacogenomics 7:387-94. 2006
    ..These data support the hypothesis that medically unexplained chronic fatigue is heterogeneous and presents preliminary evidence of the genetic mechanisms underlying some of the putative conditions...
  86. ncbi Psychological and stress hormone correlates in early life: a key to HPA-axis dysregulation and normalisation
    Julie M Turner-Cobb
    Department of Psychology, University of Bath, UK
    Stress 8:47-57. 2005
    ..Longitudinal studies incorporating measures of acute physical health outcome and of learning and memory are clearly needed...
  87. ncbi Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis
    Patrizia Porcu
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 84:618-27. 2006
    ..These data suggest that PREG responses to dexamethasone challenge may represent a trait marker of alcohol drinking. The lack of effect of ethanol on PREG levels suggests differential regulation in non-human primates vs. rodents...
  88. ncbi The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease
    Marina O'Kane
    Department of Dermatology, Adelaide and Meath Hospital, Dublin 24, Ireland
    Exp Dermatol 15:143-53. 2006
    ..This stress may be psychological or physical. CRH, produced locally or delivered by peripheral nerves, may mediate interactions between a cutaneous HPA axis-like system and the central HPA axis--the "brain-skin axis"...
  89. ncbi Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress
    A J Tilbrook
    Department of Physiology, Monash University, Victoria, Australia
    Front Neuroendocrinol 27:285-307. 2006
    ..The possible roles of inhibitory central inputs to CRH and AVP neurons and of oxytocin and prolactin in attenuating the HPA axis responses to stress are unknown...
  90. ncbi Unkind cytokines: current evidence for the potential role of cytokines in immune-mediated depression
    Michele L Pucak
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287 7121, USA
    Int Rev Psychiatry 17:477-83. 2005
    ....
  91. ncbi Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 31:2591-9. 2006
    ....
  92. ncbi Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats
    Emily L Thompson
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    Am J Physiol Endocrinol Metab 291:E1074-82. 2006
    ..These findings indicate that kisspeptin may provide a novel tool for the manipulation of the HPG axis and spermatogenesis...
  93. ncbi Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of chronic widespread musculoskeletal pain: findings of a population-based prospective cohort study
    J McBeth
    University of Manchester, Manchester, UK
    Arthritis Rheum 56:360-71. 2007
    ..To test the hypothesis that abnormalities in the hypothalamic-pituitary-adrenal (HPA) stress-response system would act as an effect moderator between HPA function and the onset of chronic widespread pain (CWP)...
  94. ncbi Administration of kisspeptin-54 into discrete regions of the hypothalamus potently increases plasma luteinising hormone and testosterone in male adult rats
    M Patterson
    Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London, UK
    J Neuroendocrinol 18:349-54. 2006
    ..Our results suggest that kisspeptin may mediate its effects on the HPG axis via these regions of the hypothalamus...
  95. ncbi Glucocorticoid action networks and complex psychiatric and/or somatic disorders
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, 11527 Athens, Greece
    Stress 10:213-9. 2007
    ....
  96. ncbi Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppression
    Catherine A Roca
    Office of Special Populations, National Institute of Mental Health, Rockville, Maryland 20857, USA
    J Clin Endocrinol Metab 90:4224-31. 2005
    ..Sex-related differences in reproductive steroid levels further confound efforts to define the specific role of the sex of the individual in stress axis responsivity...
  97. ncbi Prior stressor exposure primes the HPA axis
    John D Johnson
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Psychoneuroendocrinology 27:353-65. 2002
    ..IS significantly increased plasma CORT 15 min after pedestal exposure, but not after 30 or 60 min. These results suggest that exposure to IS sensitizes the CORT and ACTH response to subsequent HPA activation...
  98. ncbi Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol
    Mariangela Serra
    Department of Experimental Biology, Center of Excellence for Neurobiology of Drug Dependence, University of Cagliari, Cagliari, Italy
    J Neurochem 85:257-63. 2003
    ..Social isolation also induced hyper-responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis, as was apparent after reduction of GABA-mediated inhibitory tone by isoniazid administration...
  99. ncbi Individual differences in salivary cortisol and alpha-amylase in mothers and their infants: relation to tobacco smoke exposure
    Douglas A Granger
    Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA
    Dev Psychobiol 49:692-701. 2007
    ..The findings are discussed in relation to the influence of smoking tobacco on the validity of salivary biomarkers of stress...
  100. ncbi The effects of child maltreatment on the hypothalamic-pituitary-adrenal axis
    Elizabeth Van Voorhees
    Virginia Polytechnic Institute and State University, USA
    Trauma Violence Abuse 5:333-52. 2004
    ....
  101. ncbi Low-dose dexamethasone suppression test in chronic fatigue syndrome and health
    Jens Gaab
    Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
    Psychosom Med 64:311-8. 2002
    ..The aim of this study was to examine the negative feedback regulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome...

Research Grants69

  1. MECHANISMS GOVERNING INITIATION OF OVULATION
    Douglas Foster; Fiscal Year: 1980
    ....
  2. DST and Suicide Prediction
    Elizabeth Young; Fiscal Year: 2003
    ....
  3. HPA Axis in Depression and Anxiety
    Elizabeth Young; Fiscal Year: 2005
    ....
  4. BIOLOGY OF COMORBID DEPRESSION AND ANXIETY
    Elizabeth Young; Fiscal Year: 2001
    ..The results of these studies will provide data on whether the biology of these disorders support the nosological distinction between panic disorder, pure major depression and major depression with co-morbid panic disorder. ..
  5. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  6. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  7. Neuronal Risk Markers for Nicotine Dependence in Youth
    Uma Rao; Fiscal Year: 2010
    ..abstract_text> ..
  8. Risk for Substance Abuse in Depressed Adolescents
    Uma Rao; Fiscal Year: 2006
    ..More focused and effective treatments potentially might be helpful in reducing the risk for SUD in depressed youth. Moreover, such treatment strategies can be extended for testing in non-depressed youth. ..
  9. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  10. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  11. Stress and Risk for Substance Abuse in Adolescents
    Uma Rao; Fiscal Year: 2008
    ..The identification of specific vulnerabilities and associated biological alterations will aid in the development of more focused and effective pharmacological and psychosocial interventions to reduce the risk of SUD in such youth. ..
  12. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ....
  13. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
  14. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  15. Stress Response and Smoking Cessation in Depressed Youth
    Uma Rao; Fiscal Year: 2007
    ..Results of the proposed study might lead to treatment for both depression and nicotine dependence in adolescent patients. ..
  16. Markers of Risk for Nicotine Dependence in Youngsters
    Uma Rao; Fiscal Year: 2006
    ..Even if only a small subgroup of youngsters at risk for ND can be identified by such means, because of the many direct as well as indirect negative consequences associated with ND, this will be of great public health importance. ..
  17. Genetics, Endocrinology and PTSD Risk in the Population
    Rachel Yehuda; Fiscal Year: 2006
    ..The development of models of prevention and treatment of PTSD can only occur following an understanding of individual risk factors and their interactions with event exposure. ..
  18. Biology of Risk of PTSD in Holocaust Survivor Offspring
    Rachel Yehuda; Fiscal Year: 2006
    ..The subjects will be further subdivided so that there are 40 in each group with and without PTSD; half of each subgroup will have a current depressive disorder. Thus, we will recruit a total of 20 subjects in each of 12 subgroups. ..
  19. Relationship between Bio and Psych Correlates of PTSD
    Rachel Yehuda; Fiscal Year: 2005
    ..abstract_text> ..
  20. Psychobiology of PTSD: A Decade of Progress
    Rachel Yehuda; Fiscal Year: 2005
    ..We also expect the conference to be attractive to educated lay individuals such as consumers, family members, advocates, and members of the press who are interested in tracking the development of knowledge in this area. ..
  21. NeuroBehavioral Correlates of Early Deprivation
    Megan Gunnar; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  22. Developmental Psychobiology of Stress in Children
    Megan Gunnar; Fiscal Year: 2006
    ..abstract_text> ..
  23. Early Experience, Stress Neurobiology & Prevention Sci
    Megan Gunnar; Fiscal Year: 2005
    ....
  24. Psychobiological studies of stress in young children
    Megan Gunnar; Fiscal Year: 2005
    ..We argue that normative developmental research complements and provides basic data necessary for research and theory on developmental psychopathology. ..
  25. Risk for Depression Stress and Neuroendocrine Function
    AUDREY TYRKA; Fiscal Year: 2008
    ..This R01 proposal will entail a prospective longitudinal investigation of the effects of childhood adversity and maternal mood and anxiety disorders on the development of neuroendocrine dysfunction and psychopathology. ..
  26. Cognitive Modulation of Human Neuroendocrine Stress Axis
    James Abelson; Fiscal Year: 2005
    ..Existing animal data will be used to identify factors within the cognitive intervention which likely account for its potency and dismantling studies will be done to examine the separable effects of these factors. ..
  27. ADJUSTMENT OF INTERNATIONALLY ADOPTED CHILDREN
    Megan Gunnar; Fiscal Year: 2002
    ..This work will add significantly to our understanding of the health and behavioral sequelae of early adversity and th potential impact of early adversity on stress-sensitive limbic-hypothalamic processes. ..
  28. PROGRAMMING GLUCOCORTICOID SECRETION DURING FETAL LIFE
    David Phillips; Fiscal Year: 2003
    ..g. obesity reduction). ..
  29. Sex Differences in Hippocampal Synaptic Protein & mRNA
    Russell Romeo; Fiscal Year: 2005
    ..Finally, additional experiments will provide novel information on how exposure to steroid hormones during prenatal development sexually differentiates the ability of estrogen to affect hippocampal synapses. ..
  30. Lofexidine to Prevent Stress-Related Opiate Relapse
    Rajita Sinha; Fiscal Year: 2007
    ..abstract_text> ..
  31. Anatomical Plasticity and HPA Axis Dysfunction
    James Herman; Fiscal Year: 2009
    ..Overall, this project will provide critical new information on hypothalamic mechanisms mediating neuroendocrine dysfunction in affective disease states. ..
  32. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
    ..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
  33. Glucocorticoid Receptor Mechanisms, Stress and Aging
    James Herman; Fiscal Year: 2006
    ..abstract_text> ..
  34. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2008
    ..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..
  35. Sex-Specific Pathways Linking Stress and Drug Abuse
    Rajita Sinha; Fiscal Year: 2008
    ..Such an understanding will have important implications for the development of gender-specific treatments for cocaine dependence that will ultimately improve the health of cocaine-addicted women and their families. ..
  36. Individual differences in maternal behavior in the rat
    Michael Meaney; Fiscal Year: 2007
    ..abstract_text> ..
  37. Combinatorial Genomics in Cancer
    Steve W Cole; Fiscal Year: 2010
    ..The bioinformatic tools produced in these studies will create a generalized analytic infrastructure for mapping complex etiologies in cancer and deploying patient-specific targeted therapies. ..
  38. Maternal Programming of Gene Expression Through DNA Methylation
    MICHAEL JOSEPH MEANEY; Fiscal Year: 2010
    ..abstract_text> ..
  39. Effects of social factors on cardiac arrest outcome
    ANNE DEVRIES; Fiscal Year: 2009
    ....
  40. Behavioral effects of cardiac arrest in mice
    ANNE DEVRIES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 2007
    ..The experiments described in this revised application were designed with these stipulations in mind, taking into consideration the recommendations of the reviewers of the previous submission. ..
  42. DETERMINANTS OF DRUG EFFECTS ON DRUG MAINTAINED BEHAVIOR
    NICHOLAS GOEDERS; Fiscal Year: 2001
    ..abstract_text> ..
  43. Role for the HPA Axis in Methamphetamine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2005
    ..abstract_text> ..
  44. STRESS AND THE NEUROBIOLOGY OF DRUG AND ALCOHOL DEPENDE
    NICHOLAS GOEDERS; Fiscal Year: 2004
    ..The primary goal of this Training Program is to provide students and young scientists with comprehensive guidance in stress and drug abuse research. ..
  45. Autonomic nervous system control of HIV-1 replication
    Steve Cole; Fiscal Year: 2005
    ..Such interventions would enhance the efficacy of current antiretroviral treatment regimens by opposing physiologic processes that support ongoing pathogenesis. ..
  46. Early Chronic Stress and Prefrontal Development
    David Lyons; Fiscal Year: 2005
    ..abstract_text> ..
  47. Dissociation: HPA Axis and Cognition
    Daphne Simeon; Fiscal Year: 2004
    ..At the conclusion of the study, the three groups will be compared with respect to HPA axis function, cognition, childhood/lifetime trauma, symptomatology, and their interrelations. ..
  48. SOCIOBIOLOGICAL FACTORS IN EXPERIMENTAL STROKE OUTCOME
    ANNE DEVRIES; Fiscal Year: 2004
    ..abstract_text> ..
  49. Prediction of Psychosis in Schizotypal Adolescents
    Elaine Walker; Fiscal Year: 2006
    ..In the long-term, the research holds promise for yielding findings that have implications for our conceptualization of the prodromal course of schizophrenia and other psychoses, and for approaches to preventive intervention. ..
  50. Individual Differences in Mesolimbic Dopamine Systems
    Michael Meaney; Fiscal Year: 2003
    ..We feel that these studies will provide us with an understanding of the way in which early environmental events might contribute to the development of individual differences in neural systems that mediate drug-seeking behavior. ..
  51. BRAIN-PITUITARY-ADRENAL INTERRELATIONSHIPS
    Mary Dallman; Fiscal Year: 2007
    ..The information should be useful for therapeutic advice for overweight, stressed people, and possibly provide insights into mechanisms underlying different types of depressive and anxiety disorders [unreadable] [unreadable]..
  52. Chronic stress intensifies incentive relativity
    Mary Dallman; Fiscal Year: 2006
    ..abstract_text> ..
  53. PSYCHOPHYSIOLOGY OF ADAPTATION--CHILDREN IN HEAD START
    Clancy Blair; Fiscal Year: 2002
    ....
  54. Neurochemistry of Cocaine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2002
    ..These results will also provide evidence of the role that is played by steroid hormones in shaping the functional activity of the brain. ..
  55. TRANSCRIPTION-REGULATING VECTORS FOR ANTIVIRAL VACCINES
    Steve Cole; Fiscal Year: 2002
    ..abstract_text> ..
  56. Biological Actions of a Gonadotrophin-Inhibitory Peptide
    John Wingfield; Fiscal Year: 2004
    ..The studies outlined in this application will provide a new level of understanding of the neural basis of reproduction that can then be applied to reproductive research in general. ..
  57. Cytokine-CRH Interactions in IFN-alfa-Induced Depression
    Charles Raison; Fiscal Year: 2009
    ..abstract_text> ..
  58. Prenatal Programming of Infant Temperament
    Elysia Davis; Fiscal Year: 2008
    ..Prospective studies, such as this one, are needed to better understand processes that might underlie this association. [unreadable] [unreadable] [unreadable]..
  59. A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    William Coryell; Fiscal Year: 2007
    ..Analysis of the existing sib pair families plus this large set of cases and controls should permit the confirmation of several vulnerability genes during this grant period. ..
  60. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESES BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2008
    ..B) Since the melanocortin system represents the indirect pathway of action on TRH neurons, we will also determine whether alpha- MSH affects the biosynthesis, maturation and activity of PCI, PC2, proSAAS, 7B2 and CPE. ..
  61. ProTRH sorting to the regulated secretory pathway
    EDUARDO NILLNI; Fiscal Year: 2006
    ..The sorting of the proTRH N- and C-terminal fragments is routed to two different pathways. Aim 4. The tertiary structure of proTRH contributes to its processing by PC1 and PC2 and further sorting to the RSP. ..
  62. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  63. Seasonal Plasticity of Brain and Behavior
    Leah Pyter; Fiscal Year: 2005
    ..3) To determine whether photoperiod also affects non-spatial learning and memory tasks. This research will provide insights into the mechanisms of seasonal plasticity of brain and behavior ..
  64. Contraceptive efficacy and body weight: Does obesity affect the risk of failure?
    Alison Edelman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  65. Family Connections Across Generations and Nations
    James Jackson; Fiscal Year: 2006
    ..The proposed study will help us anticipate, understand, and design support programs to cope with the challenges and problems facing individuals at all generation positions, families, and societies in the new century. ..
  66. Depression, Stress & Health: Role of Anabolic Hormones
    Elissa Epel; Fiscal Year: 2006
    ..If warranted, future research will compare effects of stress reduction and hormonal supplementation on mood and disease risk. ..