Genomes and Genes
hypothalamo hypophyseal system
Summary: A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.
Publications264 found, 100 shown here
- Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stressConstantine Tsigos
Hellenic National Diabetes Center, Athens, Greece
J Psychosom Res 53:865-71. 2002....
- Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE statesP W Gold
Clinical Neuroendocrinology Branch, Intramural Research Program, NIMH NIH, NIH Clinical Center, Room 2D 46 1284, Bethesda, MD 20892 1284, USA
Mol Psychiatry 7:254-75. 2002....
- Risky families: family social environments and the mental and physical health of offspringRena L Repetti
Department of Psychology, University of California, Los Angeles, 90095 1563, USA
Psychol Bull 128:330-66. 2002..We conclude that childhood family environments represent vital links for understanding mental and physical health across the life span...
- Glucocorticoid receptors in major depression: relevance to pathophysiology and treatmentC M Pariante
Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
Biol Psychiatry 49:391-404. 2001..Further elucidation of the biochemical and molecular mechanisms involved in GR changes in major depression is an exciting frontier that will no doubt lead to new insights into the pathophysiology and treatment of affective disorders...
- Chronic stress and obesity: a new view of "comfort food"Mary F Dallman
Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
Proc Natl Acad Sci U S A 100:11696-701. 2003..These mechanisms, determined in rats, may explain some of the epidemic of obesity occurring in our society...
- Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challengeBrigitte M Kudielka
Jacobs Center on Lifelong Learning and Institutional Development, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
Psychoneuroendocrinology 34:2-18. 2009....
- Genetic factors, perceived chronic stress, and the free cortisol response to awakeningS Wust
Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstrasse 10 11, 54290, Trier, Germany
Psychoneuroendocrinology 25:707-20. 2000..In line with several recent studies, the present findings further support the view that the cortisol awakening responses is consistently enhanced under chronic stress conditions...
- Is the cortisol awakening rise a response to awakening?Ines Wilhelm
Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
Psychoneuroendocrinology 32:358-66. 2007..Although the cortisol awakening response is modulated by circadian influences, it primarily reflects phasic psychophysiological processes specific to the sleep-wake transition...
- Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animalsAntonio Armario
Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
Neurosci Biobehav Rev 32:1121-35. 2008..This is particularly critical when trying to model post-traumatic stress disorders (PTSD), which demands a great effort to validate such putative models...
- Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampusK Mizoguchi
Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
Neuroscience 119:887-97. 2003....
- Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integrationJames P Herman
Department of Psychiatry, University of Cincinnati, Psychiatry North, Bldg 43, UC E, 2nd Fl, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
Ann N Y Acad Sci 1018:35-45. 2004..As such, these neurons are positioned to summate limbic inputs into net inhibitory tone on the PVN and may thus play a major role in HPA dysfunction seen in affective disease states and aging...
- Corticosteroid insufficiency in acutely ill patientsMark S Cooper
Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
N Engl J Med 348:727-34. 2003
- Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in ratsGreg M Anderson
Department of Anatomy and Structural Biology, Centre for Neuroendocrinology, University of Otago School of Medical Sciences, Dunedin, New Zealand
Endocrinology 150:1834-40. 2009..This effect may include actions of RFRP-3 on GnRH neurons and/or their anteroventral periventricular afferent inputs but is unlikely to involve direct inhibition of LH secretion at the level of the gonadotrope...
- Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakeningMarita Pruessner
Douglas Hospital Research Center, McGill University, and McConnell Brain Imaging Centre, Montreal Neurological Hospital, McGill University, Montreal, Canada
Psychosom Med 65:92-9. 2003..The goal of the present study was to investigate the association of self-reported depressive symptomatology with early morning free cortisol levels and their relationship to measures of stress...
- Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male ratsElizabeth D Kirby
Helen Wills Neuroscience Institute, University of California Berkeley, 3060 VLSB 3140, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 106:11324-9. 2009....
- Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depressionNicholas Barden
Neuroscience Research Department, Centre Hospitalier de l Université Laval Research Centre, Sainte Foy, QC
J Psychiatry Neurosci 29:185-93. 2004..This new insight into antidepressant drug action suggests a novel approach to the development of antidepressant drugs...
- Developmental changes in gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica) hypothalamo-hypophysial systemT Ubuka
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
J Endocrinol 178:311-8. 2003..These results suggest that GnIH begins its function around hatch and acts as a hypothalamic factor to regulate gonadotropin release in the bird...
- Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease?Rainer H Straub
Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042, Germany
J Neuroimmunol 126:116-25. 2002..It is discussed how the uncoupling of the two anti-inflammatory stress axes can appear...
- Hypothalamic-pituitary-adrenal axis impairment in the pathogenesis of rheumatoid arthritis and polymyalgia rheumaticaM Cutolo
University of Genova, Genova, Italy
J Endocrinol Invest 25:19-23. 2002..Given its multifaceted properties, including the ability to counteract the negative side effects of glucocorticoids, the therapeutical administration of DHEA might be considered in these pathologies, provided its safety is proved...
- Synthesis, transport, and release of posterior pituitary hormonesM J Brownstein
Science 207:373-8. 1980..The precursors seem to be processed into smaller, biologically active molecules while they are being transported along the axon...
- Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behaviorMaureen P Boyle
Department of Pediatrics, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 102:473-8. 2005....
- Increased corticosterone pulse frequency during adjuvant-induced arthritis and its relationship to alterations in stress responsivenessR J Windle
Department of Medicine, University of Bristol, Bristol Royal Infirmary, Bristol, UK
J Neuroendocrinol 13:905-11. 2001..v. lipopolysaccharide. Thus, altered basal pulse frequency is a major factor influencing HPA activation during acute psychological stress...
- Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesisSimone Macri
Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, National Institute of Health ISS, Viale Regina Elena 299, 00161 Rome, Italy
Horm Behav 50:667-80. 2006....
- Sex differences in HPA axis responses to stress: a reviewBrigitte M Kudielka
Department of Clinical and Theoretical Psychobiology, University of Trier, Johanniterufer 15, D 54290 Trier, Germany
Biol Psychol 69:113-32. 2005
- Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeysPatrizia Porcu
Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7178, USA
Psychopharmacology (Berl) 186:293-301. 2006..However, little data are available for male nonhuman primates...
- Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapyLucile Capuron
Department of Psychiatry and Behavioral Sciences and the Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Am J Psychiatry 160:1342-5. 2003..The authors assessed the relationship between the hypothalamic-pituitary-adrenal (HPA) axis response to interferon-alpha (IFN-alpha) and the development of major depression during IFN-alpha treatment...
- The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependentIlona S Federenko
Department of Clinical and Theoretical Psychobiology, University of Trier, Germany
J Clin Endocrinol Metab 89:6244-50. 2004..These findings challenge previous reports on a low heritability of markers of stimulated hypothalamus pituitary adrenal axis activity and are the first to document the relevance of context for psychoendocrine heritability estimates...
- Glucocorticoid receptor function in vitro in patients with major depressionCarmine M Pariante
Stress, Psychiatry and Immunology Laboratory, Section of Clinical Neuropharmacology, Division of Psychological Medicine, Institute of Psychiatry, King s College London, Denmark Hill, UK
Stress 7:209-19. 2004....
- Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolismT C Baghai
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
Mol Psychiatry 11:1003-15. 2006..We could show that SNP rs4291 influences ACE activity and HPA-axis hyperactivity and might therefore represent a common pathophysiologic link for unipolar depression and cardiovascular disease...
- Evidence for altered hypothalamus-pituitary-adrenal axis functioning in systemic hypertension: blunted cortisol response to awakening and lower negative feedback sensitivityPetra H Wirtz
Department of Clinical Psychology and Psychotherapy, Psychological Institute, University of Zurich, Binzmuhlestrasse 14 Box 26, CH 8050 Zurich, Switzerland
Psychoneuroendocrinology 32:430-6. 2007..We explored HPA axis activity and feedback sensitivity to oral administration of dexamethasone in systemic hypertension via assessment of the cortisol awakening response (CAR) and the circadian cortisol profile...
- Dissociable effects of isolation rearing and environmental enrichment on exploration, spatial learning and HPA activity in adult ratsNicole C A Schrijver
Institute of Animal Sciences, Physiology and Animal Husbandry, ETH Zurich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland
Pharmacol Biochem Behav 73:209-24. 2002....
- Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient miceH J Harris
Molecular Endocrinology, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, United Kingdom
Endocrinology 142:114-20. 2001..Thus 11beta-HSD-1 amplifies glucocorticoid feedback on the HPA axis and is an important regulator of neuronal glucocorticoid exposure under both basal and stress conditions in vivo...
- Hypothalamic-pituitary-adrenal axis function and prolactin secretion in systemic lupus erythematosusM A Gutierrez
Department of Clinical Immunology and Rheumatology, Pontificia Universidad Catolica de Chile, Santiago
Lupus 7:404-8. 1998..02) and 0-90 min (P = 0.01) after TRH injection. These findings suggest that active SLE is associated with some degree of dysfunction of the hypothalamic-pituitary-glucocorticoid axis and PRL secretion...
- Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challengesB Klimes-Dougan
Department of Psychology, The Catholic University of America, Washington DC 20064, USA
Dev Psychopathol 13:695-719. 2001..These and other results suggest that gender is an important moderating factor linking psychopathology. development, and context with HPA axis functioning in adolescence...
- Intact adrenocorticotropic hormone secretion but impaired cortisol response in patients with active rheumatoid arthritis. Effect of glucocorticoidsB Gudbjornsson
Department of Medicine, Uppsala University Hospital, Sweden
J Rheumatol 23:596-602. 1996..To study the hypothalamic-pituitary-adrenal axis in rheumatoid arthritis (RA) and the influence of glucocorticoid treatment...
- Sleep and the hypothalamo-pituitary-adrenocortical systemAxel Steiger
Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
Sleep Med Rev 6:125-38. 2002..Some data suggest a major effect of light on cortisol secretion. Sleeping is widely associated with blunting and awakenings are linked with increases of HPA hormones...
- Vasopressin: behavioral roles of an "original" neuropeptideHeather K Caldwell
Section on Neural Gene Expression, NIMH, NIH, DHHS, Bethesda, MD 20892, United States
Prog Neurobiol 84:1-24. 2008..In this review, we concentrate on the scientific progress that has been made in understanding the role of Avp in regulating these and other behaviors across species. We also discuss the implications for human behavior...
- Neurochemical regulation of sleepAxel Steiger
Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
J Psychiatr Res 41:537-52. 2007....
- Neural regulation of endocrine and autonomic stress responsesYvonne M Ulrich-Lai
Department of Psychiatry, University of Cincinnati, Ohio 45237 0506, USA
Nat Rev Neurosci 10:397-409. 2009....
- Non-invasive stress-free application of glucocorticoid ligands in miceSergiu Dalm
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
J Neurosci Methods 170:77-84. 2008..In conclusion, the context-dependent and dose-controlled application of drugs via oats avoids confounding strong stress system activation and makes it suitable for studies on learning and memory processes...
- What stress does to your brain: a review of neuroimaging studiesKatarina Dedovic
Student, Douglas Mental Health University Institute, Verdun, Quebec
Can J Psychiatry 54:6-15. 2009..The goal of this review is to, first, summarize results from these studies from a perspective of task design and, second, assess the appropriateness of the different stress tasks used...
- Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2T Kishimoto
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA
Nat Genet 24:415-9. 2000..Both respond with increased edema formation in response to thermal exposure, however, indicating that in contrast to its central role in anxiety, the peripheral role of Crhr2 in vascular permeability is independent of gender...
- Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infectionMarni N Silverman
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, Georgia 30322, USA
Viral Immunol 18:41-78. 2005....
- The neurobiology of stress: from serendipity to clinical relevanceB S McEwen
Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, Box 165, 10021, New York, NY, USA
Brain Res 886:172-189. 2000..Stress-induced structural changes in brain regions such as the hippocampus have clinical ramifications for disorders such as depression, post-traumatic stress disorder and individual differences in the aging process...
- Sex, aggression and impulse control: an integrative accountDaniel Strüber
Brain Research Institute, University of Bremen, Bremen, Germany
Neurocase 14:93-121. 2008..A model is proposed that relates impulse control and its neurobiological correlates to sex differences in direct aggression...
- Innovative approaches for the treatment of depression: targeting the HPA axisFiona Thomson
Department of Molecular Pharmacology, Organon Laboratories Ltd, Newhouse, Lanarkshire, ML1 5SH, UK
Neurochem Res 33:691-707. 2008..Agents that intervene with the mechanisms involved in (dys)regulation of cortisol synthesis and release are under investigation as possible therapeutic agents. The current status of some of these approaches is described in this review...
- Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stressS Ma
Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
J Neuroendocrinol 17:22-8. 2005....
- Vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptationG Aguilera
Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bldg 10, Rm 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892 1862, USA
Regul Pept 96:23-9. 2000..The data suggest that vasopressinergic regulation of the HPA axis is critical for sustaining corticotroph responsiveness in the presence of high circulating glucocorticoid levels during chronic stress...
- Stress and the female reproductive systemS N Kalantaridou
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Ioannina, School of Medicine, Panepistimiou Avenue, 45500 Ioannina, Greece
J Reprod Immunol 62:61-8. 2004..Postpartum, this hypercortisolism is followed by a transient adrenal suppression, which may explain the blues/depression and increased autoimmune phenomena observed during this period...
- Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patientsCornelius Schule
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
Psychoneuroendocrinology 31:1019-25. 2006....
- The hypothalamic-pituitary-adrenal-axis in the regulation of energy balanceArie G Nieuwenhuizen
Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Physiol Behav 94:169-77. 2008..In the Western society, with chronically high ambient levels of stress and the availability of high caloric foods, this relationship may imply a risk for the development of (visceral) obesity and the metabolic syndrome...
- Growth hormone and prolactin response to apomorphine in bipolar and unipolar depressionHeather McPherson
Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
J Affect Disord 76:121-5. 2003..This was investigated by measuring growth hormone (GH) or prolactin (PRL) response to apomorphine (APO), a dopamine receptor agonist, in patients with bipolar depression, unipolar depression and control subjects...
- Modulation of stress responses: how we cope with excess glucocorticoidsMary F Dallman
Department of Physiology, UCSF, San Francisco, CA 94143, USA
Exp Neurol 206:179-82. 2007
- Cortisol pulsatility and its role in stress regulation and healthElizabeth A Young
Department of Psychiatry, The University of Michigan, USA
Front Neuroendocrinol 25:69-76. 2004..In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease...
- Hypothalamo-pituitary-adrenal axis activity predicts disease progression in multiple sclerosisStefan M Gold
Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
J Neuroimmunol 165:186-91. 2005..Furthermore, HPA axis activity correlated with progression ratings and cognitive impairment three years later. Tests of HPA axis activity may be useful biomarkers for disease progression in MS...
- Hypothalamic-pituitary-adrenocortical axis dysregulation in patients with major depression is influenced by the insertion/deletion polymorphism in the angiotensin I-converting enzyme geneThomas C Baghai
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
Neurosci Lett 328:299-303. 2002..The HPA axis stimulating properties of higher ACE and consecutively higher AT-II and/or lower substance P concentrations may be crucial factors for the HPA system hyperactivity during major depressive episodes...
- Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulationJens Gaab
Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
Psychosom Med 64:951-62. 2002..Because the HPA axis is involved in the adaptive responses to stress and CFS patients experience a worsening of symptoms after physical and psychological stress, we tested HPA axis functioning with three centrally acting stress tests...
- Several daily measurements are necessary to reliably assess the cortisol rise after awakening: state- and trait componentsJ Hellhammer
Department of Psychobiology, University of Trier, D 54295 Trier, Germany
Psychoneuroendocrinology 32:80-6. 2007....
- Central administration of cocaine- and amphetamine-regulated transcript increases phosphorylation of cAMP response element binding protein in corticotropin-releasing hormone-producing neurons but not in prothyrotropin-releasing hormone-producing neurons iSumit Sarkar
Tupper Research Institute and Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
Brain Res 999:181-92. 2004....
- Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axisJames P Herman
Department of Psychiatry, Psychiatry North, ML 0506 2170 East Galbraith Road, University of Cincinnati College of Medicine, OH 45237 0506, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:1201-13. 2005....
- The significance of glucocorticoid pulsatilityStafford L Lightman
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY
Eur J Pharmacol 583:255-62. 2008..This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor...
- Interactions of chronic lead exposure and intermittent stress: consequences for brain catecholamine systems and associated behaviors and HPA axis functionMiriam B Virgolini
Environmental and Occupational Health Sciences Institute, a Joint Institute of the Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, 08854, USA
Toxicol Sci 87:469-82. 2005....
- Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axisSachin Patel
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Endocrinology 145:5431-8. 2004....
- Maternal care and the development of stress responsesD D Francis
Developmental Neuroendocrinology Laboratory Douglas Hospital Research Center Departments of Psychiatry and Neurology and Neurosurgery 6875 Boul LaSalle McGill University Montréal Canada H4H 1R3
Curr Opin Neurobiol 9:128-34. 1999....
- Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic reviewHarald Jorn Schneider
Neuroendocrinology Group, Max Planck Institute of Psychiatry, Munich, Germany
JAMA 298:1429-38. 2007..This sequela is a potentially serious but treatable complication of brain injury...
- The HPA and immune axes in stress: the involvement of the serotonergic systemB E Leonard
Pharmacology Department, National University of Ireland, Galway, Ireland
Eur Psychiatry 20:S302-6. 2005....
- Permanent alterations in stress responsivity in female offspring subjected to combined maternal lead exposure and/or stressM B Virgolini
Environmental and Occupational Health Sciences Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
Neurotoxicology 27:11-21. 2006....
- Glucocorticoids, chronic stress, and obesityMary F Dallman
University of California at San Francisco, San Francisco, CA 94143 0444, USA
Prog Brain Res 153:75-105. 2006..Finally, we briefly discuss the problems with this network that normally serves to aid in responses to chronic stress, in our current overindulged, and underexercised society...
- Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptineB Czeh
Division of Neurobiology, German Primate Center, 37077 Gottingen, Germany
Proc Natl Acad Sci U S A 98:12796-801. 2001..These findings provide a cellular and neurochemical basis for evaluating antidepressant treatments with regard to possible reversal of structural changes in brain that have been reported in depressive disorders...
- When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disordersCharles L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
Am J Psychiatry 160:1554-65. 2003....
- The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal careNicole M Cameron
McGill Program for the Study of Behavior, Genes and Environment, Department of Psychiatry, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, Montreal, Que, Canada H4H 1R3
Neurosci Biobehav Rev 29:843-65. 2005..Ultimately, we will need to contend with the reality that neural development, function and health are defined by social and economic influences...
- Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype 1Guo Xiang Liu
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Model Organism Research Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Neuropsychopharmacology 32:1531-9. 2007..These results showed that the absence of GAT1 affects mental status through enhancing the GABAergic system, as well as modifying the serotonergic system and the hypothalamic-pituitary-adrenal (HPA) activity in mice...
- A single exposure to immobilization causes long-lasting pituitary-adrenal and behavioral sensitization to mild stressorsXavier Belda
Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
Horm Behav 54:654-61. 2008..Long-term effects of IMO on the susceptibility to stress-induced endocrine and emotional disturbances may be relevant to the characterization of animal models of post-traumatic stress...
- Stressor specificity of central neuroendocrine responses: implications for stress-related disordersK Pacak
Pediatric and Reproductive Endocrinology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
Endocr Rev 22:502-48. 2001..The adaptive response reflects the activation of specific central circuits and is genetically and constitutionally programmed and constantly modulated by environmental factors...
- Pituitary-adrenal response to acute and repeated mild restraint, forced swim and change in environment stress in arginine vasopressin receptor 1b knockout miceL Q Stewart
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, University of Bristol, Bristol, UK
J Neuroendocrinol 20:597-605. 2008..Furthermore, the normal corticosterone response to repeated exposure to change in environment stress also requires the Avpr1b to drive HPA axis responsiveness...
- The hypothalamic-pituitary-adrenal axis of patients with severe sepsis: altered response to corticotropin-releasing hormoneS Schroeder
, , Bonn, Germany
Crit Care Med 29:310-6. 2001..In addition, the plasma cortisol response to a single CRH stimulation was impaired in nonsurvivors compared with survivors. Reduced responses to CRH stimulation may reflect a state of endocrinologic organ dysfunction in severe sepsis...
- Prenatal stress and risk for psychopathology: specific effects or induction of general susceptibility?Anja C Huizink
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, Utrecht, Netherlands
Psychol Bull 130:115-42. 2004..Therefore, the evidence supports the view that exposure to prenatal stress may result in a general susceptibility to psychopathology, rather than exerting a direct effect on a specific form of psychopathology...
- Neuropeptides and the hypothalamic-pituitary-adrenocortical (HPA) system: review of recent research strategies in depressionM Hatzinger
Psychiatric University Hospital, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
World J Biol Psychiatry 1:105-11. 2000..In conclusion, research in neuroendocrinology provided new insights into the underlying pathophysiology of depression and, in consequence, may lead to the development of new therapeutic tools...
- Adrenal insufficiency in the critically ill: a new look at an old problemPaul E Marik
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Chest 122:1784-96. 2002..HPA dysfunction is a common and underdiagnosed disorder in the critically ill. We review the risk factors, pathophysiology, diagnostic approach, and management of HPA dysfunction in the critically ill...
- Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axisMaría Inés Forray
Department of Pharmacy, Faculty of Chemistry, Catholic University of Chile, Santiago, Chile
Brain Res Brain Res Rev 47:145-60. 2004....
- Cytokines and major depressionOlga J G Schiepers
Department of Psychiatry and Neuropsychology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Prog Neuropsychopharmacol Biol Psychiatry 29:201-17. 2005....
- Clinical and biological effects of mifepristone treatment for psychotic depressionBenjamin H Flores
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305 5723, USA
Neuropsychopharmacology 31:628-36. 2006..These results suggest that short-term use of mifepristone may be effective in the treatment of PMD and may re-regulate the HPA axis. Additional blinded studies are warranted...
- The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropinAnthony P Coll
Department of Medicine, Box 232, Addenbrooke s Hospital, Cambridge CB2 2QR, United Kingdom
Endocrinology 145:4721-7. 2004..Although such glands are atrophic and hypofunctional, exposure to ACTH alone can restore their size, morphology, and corticosterone secretion...
- Importance of studying the contributions of early adverse experience to neurobiological findings in depressionChristine Heim
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuropsychopharmacology 29:641-8. 2004....
- Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigueAlicia K Smith
Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, 1600 Clifton Road, MSG41, Atlanta, GA 30333, USA
Pharmacogenomics 7:387-94. 2006..These data support the hypothesis that medically unexplained chronic fatigue is heterogeneous and presents preliminary evidence of the genetic mechanisms underlying some of the putative conditions...
- Psychological and stress hormone correlates in early life: a key to HPA-axis dysregulation and normalisationJulie M Turner-Cobb
Department of Psychology, University of Bath, UK
Stress 8:47-57. 2005..Longitudinal studies incorporating measures of acute physical health outcome and of learning and memory are clearly needed...
- Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axisPatrizia Porcu
Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
Pharmacol Biochem Behav 84:618-27. 2006..These data suggest that PREG responses to dexamethasone challenge may represent a trait marker of alcohol drinking. The lack of effect of ethanol on PREG levels suggests differential regulation in non-human primates vs. rodents...
- The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory diseaseMarina O'Kane
Department of Dermatology, Adelaide and Meath Hospital, Dublin 24, Ireland
Exp Dermatol 15:143-53. 2006..This stress may be psychological or physical. CRH, produced locally or delivered by peripheral nerves, may mediate interactions between a cutaneous HPA axis-like system and the central HPA axis--the "brain-skin axis"...
- Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stressA J Tilbrook
Department of Physiology, Monash University, Victoria, Australia
Front Neuroendocrinol 27:285-307. 2006..The possible roles of inhibitory central inputs to CRH and AVP neurons and of oxytocin and prolactin in attenuating the HPA axis responses to stress are unknown...
- Unkind cytokines: current evidence for the potential role of cytokines in immune-mediated depressionMichele L Pucak
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287 7121, USA
Int Rev Psychiatry 17:477-83. 2005....
- Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axisMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 31:2591-9. 2006....
- Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male ratsEmily L Thompson
Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
Am J Physiol Endocrinol Metab 291:E1074-82. 2006..These findings indicate that kisspeptin may provide a novel tool for the manipulation of the HPG axis and spermatogenesis...
- Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of chronic widespread musculoskeletal pain: findings of a population-based prospective cohort studyJ McBeth
University of Manchester, Manchester, UK
Arthritis Rheum 56:360-71. 2007..To test the hypothesis that abnormalities in the hypothalamic-pituitary-adrenal (HPA) stress-response system would act as an effect moderator between HPA function and the onset of chronic widespread pain (CWP)...
- Administration of kisspeptin-54 into discrete regions of the hypothalamus potently increases plasma luteinising hormone and testosterone in male adult ratsM Patterson
Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London, UK
J Neuroendocrinol 18:349-54. 2006..Our results suggest that kisspeptin may mediate its effects on the HPG axis via these regions of the hypothalamus...
- Glucocorticoid action networks and complex psychiatric and/or somatic disordersGeorge P Chrousos
First Department of Pediatrics, Athens University Medical School, 11527 Athens, Greece
Stress 10:213-9. 2007....
- Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppressionCatherine A Roca
Office of Special Populations, National Institute of Mental Health, Rockville, Maryland 20857, USA
J Clin Endocrinol Metab 90:4224-31. 2005..Sex-related differences in reproductive steroid levels further confound efforts to define the specific role of the sex of the individual in stress axis responsivity...
- Prior stressor exposure primes the HPA axisJohn D Johnson
Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
Psychoneuroendocrinology 27:353-65. 2002..IS significantly increased plasma CORT 15 min after pedestal exposure, but not after 30 or 60 min. These results suggest that exposure to IS sensitizes the CORT and ACTH response to subsequent HPA activation...
- Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanolMariangela Serra
Department of Experimental Biology, Center of Excellence for Neurobiology of Drug Dependence, University of Cagliari, Cagliari, Italy
J Neurochem 85:257-63. 2003..Social isolation also induced hyper-responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis, as was apparent after reduction of GABA-mediated inhibitory tone by isoniazid administration...
- Individual differences in salivary cortisol and alpha-amylase in mothers and their infants: relation to tobacco smoke exposureDouglas A Granger
Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA
Dev Psychobiol 49:692-701. 2007..The findings are discussed in relation to the influence of smoking tobacco on the validity of salivary biomarkers of stress...
- The effects of child maltreatment on the hypothalamic-pituitary-adrenal axisElizabeth Van Voorhees
Virginia Polytechnic Institute and State University, USA
Trauma Violence Abuse 5:333-52. 2004....
- Low-dose dexamethasone suppression test in chronic fatigue syndrome and healthJens Gaab
Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
Psychosom Med 64:311-8. 2002..The aim of this study was to examine the negative feedback regulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome...
- MECHANISMS GOVERNING INITIATION OF OVULATIONDouglas Foster; Fiscal Year: 1980....
- DST and Suicide PredictionElizabeth Young; Fiscal Year: 2003....
- HPA Axis in Depression and AnxietyElizabeth Young; Fiscal Year: 2005....
- BIOLOGY OF COMORBID DEPRESSION AND ANXIETYElizabeth Young; Fiscal Year: 2001..The results of these studies will provide data on whether the biology of these disorders support the nosological distinction between panic disorder, pure major depression and major depression with co-morbid panic disorder. ..
- Mechanistic bases for age-related androgen deficiencyJohannes Veldhuis; Fiscal Year: 2007..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 2005..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
- Neuronal Risk Markers for Nicotine Dependence in YouthUma Rao; Fiscal Year: 2010..abstract_text> ..
- Risk for Substance Abuse in Depressed AdolescentsUma Rao; Fiscal Year: 2006..More focused and effective treatments potentially might be helpful in reducing the risk for SUD in depressed youth. Moreover, such treatment strategies can be extended for testing in non-depressed youth. ..
- Novel Active Repressor Model of Human LDL-Receptor RegulationJohannes Veldhuis; Fiscal Year: 2008..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
- Ensemble Disruption of the GnRH-LH-Testosterone AxisJohannes Veldhuis; Fiscal Year: 2007..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
- Stress and Risk for Substance Abuse in AdolescentsUma Rao; Fiscal Year: 2008..The identification of specific vulnerabilities and associated biological alterations will aid in the development of more focused and effective pharmacological and psychosocial interventions to reduce the risk of SUD in such youth. ..
- ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXISJohannes Veldhuis; Fiscal Year: 2005....
- Analytical Reconstruction of Feedback Signaling in Aging MenJohannes Veldhuis; Fiscal Year: 2008..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
- THE AGING GH AXIS IN POSTMENOPAUSAL WOMENJohannes Veldhuis; Fiscal Year: 2005..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
- Stress Response and Smoking Cessation in Depressed YouthUma Rao; Fiscal Year: 2007..Results of the proposed study might lead to treatment for both depression and nicotine dependence in adolescent patients. ..
- Markers of Risk for Nicotine Dependence in YoungstersUma Rao; Fiscal Year: 2006..Even if only a small subgroup of youngsters at risk for ND can be identified by such means, because of the many direct as well as indirect negative consequences associated with ND, this will be of great public health importance. ..
- Genetics, Endocrinology and PTSD Risk in the PopulationRachel Yehuda; Fiscal Year: 2006..The development of models of prevention and treatment of PTSD can only occur following an understanding of individual risk factors and their interactions with event exposure. ..
- Biology of Risk of PTSD in Holocaust Survivor OffspringRachel Yehuda; Fiscal Year: 2006..The subjects will be further subdivided so that there are 40 in each group with and without PTSD; half of each subgroup will have a current depressive disorder. Thus, we will recruit a total of 20 subjects in each of 12 subgroups. ..
- Relationship between Bio and Psych Correlates of PTSDRachel Yehuda; Fiscal Year: 2005..abstract_text> ..
- Psychobiology of PTSD: A Decade of ProgressRachel Yehuda; Fiscal Year: 2005..We also expect the conference to be attractive to educated lay individuals such as consumers, family members, advocates, and members of the press who are interested in tracking the development of knowledge in this area. ..
- NeuroBehavioral Correlates of Early DeprivationMegan Gunnar; Fiscal Year: 2008..unreadable] [unreadable]..
- Developmental Psychobiology of Stress in ChildrenMegan Gunnar; Fiscal Year: 2006..abstract_text> ..
- Early Experience, Stress Neurobiology & Prevention SciMegan Gunnar; Fiscal Year: 2005....
- Psychobiological studies of stress in young childrenMegan Gunnar; Fiscal Year: 2005..We argue that normative developmental research complements and provides basic data necessary for research and theory on developmental psychopathology. ..
- Risk for Depression Stress and Neuroendocrine FunctionAUDREY TYRKA; Fiscal Year: 2008..This R01 proposal will entail a prospective longitudinal investigation of the effects of childhood adversity and maternal mood and anxiety disorders on the development of neuroendocrine dysfunction and psychopathology. ..
- Cognitive Modulation of Human Neuroendocrine Stress AxisJames Abelson; Fiscal Year: 2005..Existing animal data will be used to identify factors within the cognitive intervention which likely account for its potency and dismantling studies will be done to examine the separable effects of these factors. ..
- ADJUSTMENT OF INTERNATIONALLY ADOPTED CHILDRENMegan Gunnar; Fiscal Year: 2002..This work will add significantly to our understanding of the health and behavioral sequelae of early adversity and th potential impact of early adversity on stress-sensitive limbic-hypothalamic processes. ..
- PROGRAMMING GLUCOCORTICOID SECRETION DURING FETAL LIFEDavid Phillips; Fiscal Year: 2003..g. obesity reduction). ..
- Sex Differences in Hippocampal Synaptic Protein & mRNARussell Romeo; Fiscal Year: 2005..Finally, additional experiments will provide novel information on how exposure to steroid hormones during prenatal development sexually differentiates the ability of estrogen to affect hippocampal synapses. ..
- Lofexidine to Prevent Stress-Related Opiate RelapseRajita Sinha; Fiscal Year: 2007..abstract_text> ..
- Anatomical Plasticity and HPA Axis DysfunctionJames Herman; Fiscal Year: 2009..Overall, this project will provide critical new information on hypothalamic mechanisms mediating neuroendocrine dysfunction in affective disease states. ..
- NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONSCatherine Rivier; Fiscal Year: 2004..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
- Glucocorticoid Receptor Mechanisms, Stress and AgingJames Herman; Fiscal Year: 2006..abstract_text> ..
- A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASECatherine Rivier; Fiscal Year: 2008..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..
- Sex-Specific Pathways Linking Stress and Drug AbuseRajita Sinha; Fiscal Year: 2008..Such an understanding will have important implications for the development of gender-specific treatments for cocaine dependence that will ultimately improve the health of cocaine-addicted women and their families. ..
- Individual differences in maternal behavior in the ratMichael Meaney; Fiscal Year: 2007..abstract_text> ..
- Combinatorial Genomics in CancerSteve W Cole; Fiscal Year: 2010..The bioinformatic tools produced in these studies will create a generalized analytic infrastructure for mapping complex etiologies in cancer and deploying patient-specific targeted therapies. ..
- Maternal Programming of Gene Expression Through DNA MethylationMICHAEL JOSEPH MEANEY; Fiscal Year: 2010..abstract_text> ..
- Effects of social factors on cardiac arrest outcomeANNE DEVRIES; Fiscal Year: 2009....
- Behavioral effects of cardiac arrest in miceANNE DEVRIES; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATIONNICHOLAS GOEDERS; Fiscal Year: 2007..The experiments described in this revised application were designed with these stipulations in mind, taking into consideration the recommendations of the reviewers of the previous submission. ..
- DETERMINANTS OF DRUG EFFECTS ON DRUG MAINTAINED BEHAVIORNICHOLAS GOEDERS; Fiscal Year: 2001..abstract_text> ..
- Role for the HPA Axis in Methamphetamine ReinforcementNICHOLAS GOEDERS; Fiscal Year: 2005..abstract_text> ..
- STRESS AND THE NEUROBIOLOGY OF DRUG AND ALCOHOL DEPENDENICHOLAS GOEDERS; Fiscal Year: 2004..The primary goal of this Training Program is to provide students and young scientists with comprehensive guidance in stress and drug abuse research. ..
- Autonomic nervous system control of HIV-1 replicationSteve Cole; Fiscal Year: 2005..Such interventions would enhance the efficacy of current antiretroviral treatment regimens by opposing physiologic processes that support ongoing pathogenesis. ..
- Early Chronic Stress and Prefrontal DevelopmentDavid Lyons; Fiscal Year: 2005..abstract_text> ..
- Dissociation: HPA Axis and CognitionDaphne Simeon; Fiscal Year: 2004..At the conclusion of the study, the three groups will be compared with respect to HPA axis function, cognition, childhood/lifetime trauma, symptomatology, and their interrelations. ..
- SOCIOBIOLOGICAL FACTORS IN EXPERIMENTAL STROKE OUTCOMEANNE DEVRIES; Fiscal Year: 2004..abstract_text> ..
- Prediction of Psychosis in Schizotypal AdolescentsElaine Walker; Fiscal Year: 2006..In the long-term, the research holds promise for yielding findings that have implications for our conceptualization of the prodromal course of schizophrenia and other psychoses, and for approaches to preventive intervention. ..
- Individual Differences in Mesolimbic Dopamine SystemsMichael Meaney; Fiscal Year: 2003..We feel that these studies will provide us with an understanding of the way in which early environmental events might contribute to the development of individual differences in neural systems that mediate drug-seeking behavior. ..
- BRAIN-PITUITARY-ADRENAL INTERRELATIONSHIPSMary Dallman; Fiscal Year: 2007..The information should be useful for therapeutic advice for overweight, stressed people, and possibly provide insights into mechanisms underlying different types of depressive and anxiety disorders [unreadable] [unreadable]..
- Chronic stress intensifies incentive relativityMary Dallman; Fiscal Year: 2006..abstract_text> ..
- PSYCHOPHYSIOLOGY OF ADAPTATION--CHILDREN IN HEAD STARTClancy Blair; Fiscal Year: 2002....
- Neurochemistry of Cocaine ReinforcementNICHOLAS GOEDERS; Fiscal Year: 2002..These results will also provide evidence of the role that is played by steroid hormones in shaping the functional activity of the brain. ..
- TRANSCRIPTION-REGULATING VECTORS FOR ANTIVIRAL VACCINESSteve Cole; Fiscal Year: 2002..abstract_text> ..
- Biological Actions of a Gonadotrophin-Inhibitory PeptideJohn Wingfield; Fiscal Year: 2004..The studies outlined in this application will provide a new level of understanding of the neural basis of reproduction that can then be applied to reproductive research in general. ..
- Cytokine-CRH Interactions in IFN-alfa-Induced DepressionCharles Raison; Fiscal Year: 2009..abstract_text> ..
- Prenatal Programming of Infant TemperamentElysia Davis; Fiscal Year: 2008..Prospective studies, such as this one, are needed to better understand processes that might underlie this association. [unreadable] [unreadable] [unreadable]..
- A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERWilliam Coryell; Fiscal Year: 2007..Analysis of the existing sib pair families plus this large set of cases and controls should permit the confirmation of several vulnerability genes during this grant period. ..
- PROTRH GENE TRANSCRIPTION AND BIOSYNTHESES BY LEPTINEDUARDO NILLNI; Fiscal Year: 2008..B) Since the melanocortin system represents the indirect pathway of action on TRH neurons, we will also determine whether alpha- MSH affects the biosynthesis, maturation and activity of PCI, PC2, proSAAS, 7B2 and CPE. ..
- ProTRH sorting to the regulated secretory pathwayEDUARDO NILLNI; Fiscal Year: 2006..The sorting of the proTRH N- and C-terminal fragments is routed to two different pathways. Aim 4. The tertiary structure of proTRH contributes to its processing by PC1 and PC2 and further sorting to the RSP. ..
- BRAIN GALANIN RECEPTORS AND EPILEPSYAndrey Mazarati; Fiscal Year: 2006..abstract_text> ..
- Seasonal Plasticity of Brain and BehaviorLeah Pyter; Fiscal Year: 2005..3) To determine whether photoperiod also affects non-spatial learning and memory tasks. This research will provide insights into the mechanisms of seasonal plasticity of brain and behavior ..
- Contraceptive efficacy and body weight: Does obesity affect the risk of failure?Alison Edelman; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Family Connections Across Generations and NationsJames Jackson; Fiscal Year: 2006..The proposed study will help us anticipate, understand, and design support programs to cope with the challenges and problems facing individuals at all generation positions, families, and societies in the new century. ..
- Depression, Stress & Health: Role of Anabolic HormonesElissa Epel; Fiscal Year: 2006..If warranted, future research will compare effects of stress reduction and hormonal supplementation on mood and disease risk. ..