anterior pituitary gland

Summary

Summary: The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.

Top Publications

  1. ncbi Role of estrogens in anterior pituitary gland remodeling during the estrous cycle
    S Zarate
    Instituto de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Front Horm Res 38:25-31. 2010
  2. ncbi Hypophyseal lipoapoptosis: diabetes (db/db) mutation-associated cytolipidemia promotes pituitary cellular disruption and dysfunction
    Bryan L Garris
    Divisions of Cell Biology and Biophysics School of Medicine, University of Missouri Kansas City, Kansas City, Missouri 64110, USA
    Pituitary 7:5-14. 2004
  3. ncbi Gonadotrope and thyrotrope development in the human and mouse anterior pituitary gland
    Caroline Pope
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Dev Biol 297:172-81. 2006
  4. ncbi Effect of endotoxin on the expression of GnRH and GnRHR genes in the hypothalamus and anterior pituitary gland of anestrous ewes
    Andrzej Przemysław Herman
    Polish Academy of Sciences, The Kielanowski Institute of Animal Physiology and Nutrition, 05 110 Jabłonna, Poland
    Anim Reprod Sci 120:105-11. 2010
  5. ncbi Direct actions of estradiol on the anterior pituitary gland are required for hypothalamus-dependent lactotrope proliferation and secretory surges of luteinizing hormone but not of prolactin in female rats
    Ping Yin
    Department of Physiology, Yamanashi Medical University, Yamanashi, Japan
    Neuroendocrinology 75:392-401. 2002
  6. ncbi The promoter of the rat gonadotropin-releasing hormone receptor gene directs the expression of the human placental alkaline phosphatase reporter gene in gonadotrope cells in the anterior pituitary gland as well as in multiple extrapituitary tissues
    Anne Granger
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 7079, Physiologie et Physiopathologie, Universite Pierre et Marie Curie, 4 place Jussieu, Case courrier 256, 75252 Paris Cedex 05, France
    Endocrinology 145:983-93. 2004
  7. ncbi The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid
    George Wolf
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720 3104, USA
    Nutr Rev 60:374-7. 2002
  8. ncbi Temporal parenteral nutrition in children causing t1 shortening in the anterior pituitary gland and globus pallidus
    H Suzuki
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Neuropediatrics 34:200-4. 2003
  9. ncbi Regulational effect of ghrelin on growth hormone secretion from perifused rat anterior pituitary cells
    M Yamazaki
    Department of Regulation Biology, Faculty of Science, Saitama University, Shimo ohkubo, Saitama, Saitama, Japan
    J Neuroendocrinol 14:156-62. 2002
  10. ncbi Role of estrogen receptor-alpha in the anterior pituitary gland
    K M Scully
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093 0648, USA
    Mol Endocrinol 11:674-81. 1997

Detail Information

Publications192 found, 100 shown here

  1. ncbi Role of estrogens in anterior pituitary gland remodeling during the estrous cycle
    S Zarate
    Instituto de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Front Horm Res 38:25-31. 2010
    In this review, we analyze the action of estrogens leading to the remodeling of the anterior pituitary gland, especially during the estrous cycle...
  2. ncbi Hypophyseal lipoapoptosis: diabetes (db/db) mutation-associated cytolipidemia promotes pituitary cellular disruption and dysfunction
    Bryan L Garris
    Divisions of Cell Biology and Biophysics School of Medicine, University of Missouri Kansas City, Kansas City, Missouri 64110, USA
    Pituitary 7:5-14. 2004
    ....
  3. ncbi Gonadotrope and thyrotrope development in the human and mouse anterior pituitary gland
    Caroline Pope
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Dev Biol 297:172-81. 2006
    ..The mechanism(s) responsible for the different molecular regulation of alpha-GSU gene expression in gonadotropes and thyrotropes in the developing human fetal pituitary now requires investigation...
  4. ncbi Effect of endotoxin on the expression of GnRH and GnRHR genes in the hypothalamus and anterior pituitary gland of anestrous ewes
    Andrzej Przemysław Herman
    Polish Academy of Sciences, The Kielanowski Institute of Animal Physiology and Nutrition, 05 110 Jabłonna, Poland
    Anim Reprod Sci 120:105-11. 2010
    ..receptor (GnRHR) genes in the hypothalamic structures where GnRH neurons are located as well as in the anterior pituitary gland (AP) of anestrous ewes. We also determined the effect of LPS on luteinizing hormone (LH) release...
  5. ncbi Direct actions of estradiol on the anterior pituitary gland are required for hypothalamus-dependent lactotrope proliferation and secretory surges of luteinizing hormone but not of prolactin in female rats
    Ping Yin
    Department of Physiology, Yamanashi Medical University, Yamanashi, Japan
    Neuroendocrinology 75:392-401. 2002
    ..We examined whether these hypothalamus-dependent events require the direct action of estradiol on the anterior pituitary gland by selective blockade of its peripheral actions, using ICI182,780 (ICI), an antiestrogen that cannot ..
  6. ncbi The promoter of the rat gonadotropin-releasing hormone receptor gene directs the expression of the human placental alkaline phosphatase reporter gene in gonadotrope cells in the anterior pituitary gland as well as in multiple extrapituitary tissues
    Anne Granger
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 7079, Physiologie et Physiopathologie, Universite Pierre et Marie Curie, 4 place Jussieu, Case courrier 256, 75252 Paris Cedex 05, France
    Endocrinology 145:983-93. 2004
    ....
  7. ncbi The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid
    George Wolf
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720 3104, USA
    Nutr Rev 60:374-7. 2002
    Thyroid-stimulating hormone, TSH, of the anterior pituitary gland is regulated by the binding of the thyroid hormone-activated thyroid receptor to the TSH gene at the same time as the binding of the 9-cis-retinoic acid-activated retinoid ..
  8. ncbi Temporal parenteral nutrition in children causing t1 shortening in the anterior pituitary gland and globus pallidus
    H Suzuki
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Neuropediatrics 34:200-4. 2003
    ..long-term parenteral nutrition (PN) with trace elements (TE) may exhibit T (1) shortening in the anterior pituitary gland and basal ganglia...
  9. ncbi Regulational effect of ghrelin on growth hormone secretion from perifused rat anterior pituitary cells
    M Yamazaki
    Department of Regulation Biology, Faculty of Science, Saitama University, Shimo ohkubo, Saitama, Saitama, Japan
    J Neuroendocrinol 14:156-62. 2002
    ..Ghrelin specifically stimulates the release of GH from the rat anterior pituitary gland, but the regulational effect of ghrelin on GH secretion has not yet been clarified...
  10. ncbi Role of estrogen receptor-alpha in the anterior pituitary gland
    K M Scully
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093 0648, USA
    Mol Endocrinol 11:674-81. 1997
    ..to test hypotheses that estrogens exert important effects in development and homeostatic functions of the anterior pituitary gland, particularly in the lactotroph and gonadotroph cell types...
  11. ncbi A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype
    H A Ingraham
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093
    Cell 55:519-29. 1988
    ..Pit-1 mRNA is expressed exclusively in the anterior pituitary gland in both somatotroph and lactotroph cell types, which produce growth hormone and prolactin, respectively...
  12. ncbi Prolactin: structure, function, and regulation of secretion
    M E Freeman
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 4340, USA
    Physiol Rev 80:1523-631. 2000
    Prolactin is a protein hormone of the anterior pituitary gland that was originally named for its ability to promote lactation in response to the suckling stimulus of hungry young mammals...
  13. ncbi 17 beta-estradiol modifies nitric oxide-sensitive guanylyl cyclase expression and down-regulates its activity in rat anterior pituitary gland
    Jimena P Cabilla
    Departamento de Quimica Biologica, Instituto de Química y Físico química Biológicas, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, Buenos Aires C1113AAD, Argentina
    Endocrinology 147:4311-8. 2006
    ..inhibitory effect of NO on prolactin release, decreasing sGC activity and affecting the cGMP pathway in anterior pituitary gland of adult ovariectomized and estrogenized rats...
  14. ncbi Immunohistochemistry of connexin 43 throughout anterior pituitary gland in a transgenic rat with green fluorescent protein-expressing folliculo-stellate cells
    Kotaro Horiguchi
    Department of Anatomy, Jichi Medical University School of Medicine, Tochigi, Japan
    Anat Sci Int 83:256-60. 2008
    Folliculo-stellate (FS) cells in the anterior pituitary gland have been speculated to possess multifunctional properties...
  15. ncbi Intercellular communication within the rat anterior pituitary gland: X. Immunohistocytochemistry of S-100 and connexin 43 of folliculo-stellate cells in the rat anterior pituitary gland
    Nobuyuki Shirasawa
    Department of Anatomy, Yamagata University School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    Anat Rec A Discov Mol Cell Evol Biol 278:462-73. 2004
    Since Rinehart and Farquhar reported the presence of agranulated cells in the anterior pituitary gland in 1953, the functions of the folliculo-stellate cell remain to be clarified...
  16. pmc Sensitization of regulated exocytosis by protein kinase C
    Hongliang Zhu
    Institute of Biophysics and Biochemistry, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People s Republic of China
    Proc Natl Acad Sci U S A 99:17055-9. 2002
    ....
  17. ncbi The structure and function of folliculo-stellate cells in the anterior pituitary gland
    K Inoue
    Department of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan
    Arch Histol Cytol 62:205-18. 1999
    The folliculo-stellate cells (FS cells) in the anterior pituitary gland are characterized by their star-like appearance and their ability to form follicles...
  18. ncbi Cell life and death in the anterior pituitary gland: role of oestrogens
    A Seilicovich
    Instituto de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Neuroendocrinol 22:758-64. 2010
    Apoptotic processes play an important role in the maintenance of cell numbers in the anterior pituitary gland during physiological endocrine events...
  19. ncbi Functional expression and molecular characterization of the thyrotrophin-releasing hormone receptor from the rat anterior pituitary gland
    R E Sellar
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, UK
    J Mol Endocrinol 10:199-206. 1993
    ..The sequence given for the 3'-untranslated region is 1.5 kb longer than that reported for the mouse receptor, and extends to the poly(A) tail...
  20. ncbi An insight to pituitary folliculo-stellate cells
    S Devnath
    Department of Regulation Biology, Graduate School of Science and Engineering, Saitama University, Saitama, Japan
    J Neuroendocrinol 20:687-91. 2008
    Folliculo-stellate cells (FS-cells) are star-shaped and follicle-forming cells in the anterior pituitary gland that were first identified by electron microscopy as non-endocrine agranular cells...
  21. ncbi Estradiol increases the Bax/Bcl-2 ratio and induces apoptosis in the anterior pituitary gland
    Verónica Zaldivar
    Instituto de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neuroendocrinology 90:292-300. 2009
    ..The balance of pro- and antiapoptotic proteins of the Bcl-2 family is known to regulate cell survival and apoptosis...
  22. ncbi Estrogen actions on lactotroph proliferation are independent of a paracrine interaction with other pituitary cell types: a study using lactotroph-enriched cells
    Maho Ishida
    Department of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, and Division of Blood Transfusion, Shinshu University Hospital, Nagano, Japan
    Endocrinology 148:3131-9. 2007
    ..These results suggest that the antimitogenic and mitogenic actions of estrogen on lactotrophs do not require paracrine signals from other pituitary cell types and that estrogen directly influences lactotroph proliferation...
  23. ncbi Region-specific expression and hormonal regulation of the first exon variants of rat prolactin receptor mRNA in rat brain and anterior pituitary gland
    H Nogami
    Department of Neuroendocrinology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    J Neuroendocrinol 19:583-93. 2007
    ..of the long-form was detected in the choroid plexus, hypothalamus, hippocampus, cerebral cortex and anterior pituitary gland, whereas the short form was detected only in the choroid plexus...
  24. ncbi Transgenic studies on the regulation of the anterior pituitary gland function by the hypothalamus
    Sara Wells
    Molecular Neuroendocrinology Research Group, University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, UK
    Front Neuroendocrinol 24:11-26. 2003
    The anterior pituitary gland is composed of five different cell types secreting hormones whose functions include the regulation of post-natal growth (growth hormone, GH), lactation (prolactin, PRL), reproduction (luteinising hormone, LH, ..
  25. ncbi Estrogens sensitize anterior pituitary gland to apoptosis
    D Pisera
    Centro de Investigaciones en Reproduccion, Facultad de Medicina, Universidad de Buenos Aires, C1121ABG, Argentina
    Am J Physiol Endocrinol Metab 287:E767-71. 2004
    ..In the present study, we investigated the apoptotic response of the anterior pituitary gland to lipopolysaccharide (LPS) in cycling female rats, and the influence of estradiol in this response in ..
  26. pmc Folliculostellate cells determine the susceptibility of lactotropes to estradiol's mitogenic action
    Souichi Oomizu
    Endocrinology Program, Rutgers, Biomedical Divison of the Center for Alcohol Studies, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    Endocrinology 145:1473-80. 2004
    ..These data suggest that cell-cell interaction between FS cells and lactotropes regulates estradiol's mitogenic action on lactotropes and also determines lactotrope susceptibility to the steroid...
  27. ncbi Effects of ghrelin on growth hormone secretion from cultured adenohypophysial cells in cattle
    Tsutomu Hashizume
    Faculty of Agriculture, Iwate University, Ueda 3, Morioka 020 8550, Japan
    Endocr J 50:289-95. 2003
    ..05). These results show that ghrelin directly stimulates the release of GH from anterior pituitary cells, and that SS modifies ghrelin-stimulated GH release in cattle...
  28. ncbi Perinatal glucocorticoid treatment produces molecular, functional, and morphological changes in the anterior pituitary gland of the adult male rat
    E Theogaraj
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom
    Endocrinology 146:4804-13. 2005
    ....
  29. ncbi Regulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor
    A Garcia
    Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, Spain
    Mol Endocrinol 15:1484-95. 2001
    ..This factor is transcribed in a highly restricted manner in the anterior pituitary gland. The present experiments sought to determine whether the synthetic hexapeptide GHRP-6, a reference GH ..
  30. ncbi Release of luteinizing hormone from the anterior pituitary gland in vitro can be concurrently regulated by at least three peptides: gonadotropin-releasing hormone, oxytocin and neuropeptide Y
    J J Evans
    Department of Obstetrics and Gynaecology, Christchurch School of Medicine, Christchurch, New Zealand
    Neuroendocrinology 73:408-16. 2001
    ..Therefore, the concentrations of LH that are present in vivo are likely to be at least partly the result of the co-ordinated effects of combinations of peptides acting on the pituitary...
  31. pmc Estrogens up-regulate the Fas/FasL apoptotic pathway in lactotropes
    G Jaita
    Centro de Investigaciones en Reproduccion, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 10, Buenos Aires C1121ABG, Argentina
    Endocrinology 146:4737-44. 2005
    ....
  32. ncbi Calcitonin is expressed in gonadotropes of the anterior pituitary gland: its possible role in paracrine regulation of lactotrope function
    Y Ren
    Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, Texas 79106, USA
    J Endocrinol 171:217-28. 2001
    ....
  33. ncbi Quantitative evaluation of synaptophysin-like immunoreactive nerve terminals or varicosities in anterior pituitary of normal and adrenalectomized rats
    Y Y Liu
    Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China
    J Neuroendocrinol 13:967-74. 2001
    ..The increase in number following adrenalectomy was statistically significant. It is concluded that nerve fibres may play an important role in the regulation of the anterior pituitary...
  34. ncbi Aspects of anterior pituitary growth, with special reference to corticotrophs
    A M McNicol
    University Department of Pathology, Royal Infirmary, Glasgow, UK
    Pituitary 1:257-68. 1999
    ..Our data also suggest that a further expansion takes place which may reflect differentiation of a population other than committed corticotrophs...
  35. ncbi Paracrine control of lactotrope proliferation and differentiation
    Carl Denef
    Laboratory of Cell Pharmacology, University of Leuven K U Leuven, Medical School, Campus Gasthuisberg O and N, B 3000 Leuven, Belgium
    Trends Endocrinol Metab 14:188-95. 2003
    ..Moreover, the classic hormone precursor pro-opiomelanocortin generates differentially glycosylated isoforms of its N-terminal fragment as paracrine controllers, which each induce distinct aspects of lactotrope differentiation and growth...
  36. ncbi Are folliculo-stellate cells in the anterior pituitary gland supportive cells or organ-specific stem cells?
    K Inoue
    Department of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan
    Arch Physiol Biochem 110:50-3. 2002
    Folliculo-stellate cells (FS-cells) in the anterior pituitary gland are star-shaped cells and form tiny follicles...
  37. ncbi Angiotensin IV stimulates the activity of tyrosine kinases in rat anterior pituitary gland acting via AT1-like receptors?
    E Rebas
    Department of Biochemistry, Institute of Physiology and Biochemistry, Institute of Endocrinology, Medical University of Łódź
    J Physiol Pharmacol 55:107-11. 2004
    ..The involvement of a non-classic AT1-like receptor is suggested...
  38. ncbi Immunohistochemical localization of S-100 protein in the pig pituitary gland
    E Marettová
    Department of Anatomy, Histology and Physiology, University of Veterinary Medicine, Komenskeho 73, 041 81 Kosice, Slovakia
    Anat Histol Embryol 33:344-7. 2004
    ..The distribution, and morphologic characteristics of the FSc in the glandular lobes and the pituicytes in the neural lobe in the pig indicate different origin of both S-100 protein-positive cells...
  39. ncbi Annexin-1 (lipocortin-1)-immunoreactivity in the folliculo-stellate cells of rat anterior pituitary: the effect of adrenalectomy and corticosterone treatment on its subcellular distribution
    H Ozawa
    Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Neuroendocrinol 14:621-8. 2002
    ..These results confirm that glucocorticoids regulate the annexin-1 expression and demonstrate the translocation of annexin-1 from intracellular to pericellular sites in the FS cells of the rat anterior pituitary gland.
  40. ncbi Physiological implications of pituitary trophic activity
    A Levy
    University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, UK
    J Endocrinol 174:147-55. 2002
    ..This review summarizes the limited literature on pituitary trophic activity and asks what, if anything, analysis of pituitary trophic activity using current technology can tell us...
  41. ncbi The effects of testosterone and oestrogen on gonadectomised and intact male rat anterior pituitary mitotic and apoptotic activity
    L A Nolan
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    J Endocrinol 188:387-96. 2006
    ..Oestrogen, either exogenous or generated locally by aromatisation, stimulates anterior pituitary mitotic activity in a time-dependent manner...
  42. ncbi Expression and regulation of glucocorticoid-induced leucine zipper in the developing anterior pituitary gland
    Laura E Ellestad
    Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
    J Mol Endocrinol 42:171-83. 2009
    ..We have shown that GILZ is upregulated by glucocorticoids in the embryonic pituitary gland and may regulate expression of several pituitary hormones...
  43. ncbi Differential expression of ionic channels in rat anterior pituitary cells
    F Van Goor
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health Bethesda, Maryland 20892-4510, USA
    Mol Endocrinol 15:1222-36. 2001
    ....
  44. ncbi Ontogenetic changes in the expression of estrogen receptor alpha and beta in rat pituitary gland detected by immunohistochemistry
    E Nishihara
    Department of Nature Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Japan
    Endocrinology 141:615-20. 2000
    ....
  45. pmc Multifunctional cells of mouse anterior pituitary reveal a striking sexual dimorphism
    Lucía Núñez
    Instituto de Biología y Genética Molecular IBGM, Universidad de Valladolid and Consejo Superior de Investigaciones Cientificas CSIC, Valladolid, Spain
    J Physiol 549:835-43. 2003
    ..Overall, our results reveal a striking sexual dimorphism, the female pituitary being much more plastic than the male pituitary...
  46. ncbi Colloid in the anterior pituitary of helmet guinea fowl (Numida meleagris galeata): morphometric analysis and pattern of occurrence in relation to apoptosis
    Claudius Luziga
    Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Sokoine University of Agriculture, Morogoro, Tanzania
    Vet Res Commun 33:681-91. 2009
    ..The occurrence of extremely large number of colloids in relation to apoptotic profiles in anterior pituitary of helmet guinea fowl is discussed...
  47. ncbi Intercellular communication in the anterior pituitary
    J Schwartz
    Department of Physiology, University of Adelaide, SA, Australia
    Endocr Rev 21:488-513. 2000
    ..The purpose of this article is to review the recent literature on many of the factors acting as intrapituitary signals and to present such finding in the context of the physiology of the secretory cells...
  48. ncbi Transgenic mice overexpressing the growth-hormone-releasing hormone gene have high concentrations of tachykinins in the anterior pituitary gland
    L Debeljuk
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Ill, USA
    Neuroendocrinology 70:107-16. 1999
    According to recent reports, substance P (SP) is localized in the anterior pituitary gland within subsets of thyrotropes and somatotropes, although earlier electron-microscopic studies described the presence of this tachykinin in ..
  49. ncbi Anterior pituitary cell renewal during the estrous cycle
    M Candolfi
    Centro de Investigaciones en Reproduccion, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires, Argentina
    Front Horm Res 35:9-21. 2006
    The anterior pituitary gland undergoes a process of cell renewal during the estrous cycle...
  50. ncbi Gender differences and the effect of different endocrine situations on the NOS expression pattern in the anterior pituitary gland
    T Gonzalez-Hernandez
    Departments of Anatomy, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Spain
    J Histochem Cytochem 48:1639-48. 2000
    ..When released from FS cells, NO exerts a paracrine inhibitory effect, and when released from gonadotrophs it exerts an autocrine or paracrine stimulatory effect on LH or prolactin secretion, respectively...
  51. ncbi History and perspectives of pituitary folliculo-stellate cell research
    Wilfried Allaerts
    Biological Publishing, PO Box 104, NL 7440 AC Nijverdal, The Netherlands
    Eur J Endocrinol 153:1-12. 2005
    ..New approaches for the study of this enigmatic cell group using immortalized cell lines and new markers for an hitherto unrecognized pituitary cell population, the so-called 'side population', are evaluated...
  52. ncbi Changes in the population of immunoreactive S-100-positive folliculo-stellate cells in hens during induced molting
    V S Chowdhury
    Faculty of Applied Biological Science, Hiroshima University, Higashi Hiroshima, Japan
    Poult Sci 81:556-60. 2002
    ..These results suggest that FS cell population is likely to increase at the final stage of induced molting and may be involved in control of pituitary functions for the resumption of ovulation...
  53. ncbi Distinctive localization of N- and E-cadherins in rat anterior pituitary gland
    Motoshi Kikuchi
    Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Shimotsuke shi, Tochigi, Japan
    Anat Rec A Discov Mol Cell Evol Biol 288:1183-9. 2006
    In the rat anterior pituitary gland, folliculo-stellate cells aggregate preferably to form pseudofollicles, and each type of hormone-producing cell shows adhesive affinity with particular types of heterologous hormone-producing cells...
  54. ncbi Externalization of annexin I from a folliculo-stellate-like cell line
    Lee Chapman
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    Endocrinology 143:4330-8. 2002
    ..These data support our hypothesis that annexin I is released by FS cells in response to glucocorticoids to mediate glucocorticoid inhibitory actions on pituitary hormone release via a juxtacrine mechanism...
  55. ncbi Evidence for a role of the adenosine 5'-triphosphate-binding cassette transporter A1 in the externalization of annexin I from pituitary folliculo-stellate cells
    Lee P Chapman
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    Endocrinology 144:1062-73. 2003
    ..We conclude that ANXA1, which mediates the early delayed feedback of glucocorticoids in the anterior pituitary, is externalized from FS cells by an ABC transporter and that the ABCA1 transporter is a likely candidate...
  56. ncbi Dual excitatory and inhibitory effects of stimulation of intrinsic innervation of the anterior pituitary on adrenocorticotropic hormone release in the rat
    L Z Gao
    Department of Neuroendocrinology, Institute of Neurosciences, The Fourth Military Medical University, Xi an, People s Republic of China
    J Neuroendocrinol 16:5-9. 2004
    ..The results indicate that stimulation of the nerve fibres in the anterior pituitary has dual excitatory and inhibitory effects on ACTH secretion...
  57. ncbi Transcriptional regulation of interleukin-6 in pituitary folliculo-stellate TtT/GF cells
    Alberto Carbia Nagashima
    Laboratorio de Fisiologia y Biologia Molecular, Departmento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, PabellónII, Argentina
    Mol Cell Endocrinol 201:47-56. 2003
    ..The regulatory elements involved in IL-6 transcription in TtT/GF FS cells contribute to understand the specificity of the anterior pituitary gland paracrine pathways.
  58. ncbi Permissive effects of thyroid hormones on rat anterior pituitary mitotic activity
    L A Nolan
    Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson St, Bristol BS1 3NY, UK
    J Endocrinol 180:35-43. 2004
    ....
  59. ncbi Immunohistochemical study of somatotrophs in pituitary pars distalis of male viscacha (Lagostomus maximus maximus) in relation to the gonadal activity
    V Filippa
    Catedra de Histologia y Embriologia, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina
    Cells Tissues Organs 184:188-97. 2006
    ..The results obtained suggested that the variations of the morphometric parameters of somatotrophs are more related to the gonadal development and activity than to a direct effect of melatonin...
  60. ncbi Immunohistochemical evidence for the presence of glucokinase in the gonadotropes and thyrotropes of the anterior pituitary gland of rat and monkey
    Robert L Sorenson
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, USA
    J Histochem Cytochem 55:555-66. 2007
    ....
  61. ncbi A rare expression of neural crest disorders: an intrasphenoidal development of the anterior pituitary gland
    Kathlyn Marsot-Dupuch
    Department of Neuroradiology, Faculty Paris Sud, Le Kremlin Bicetre, France
    AJNR Am J Neuroradiol 25:285-8. 2004
    ..The abnormal migration of the pituitary gland was isolated without hormonal deficit, brain, or facial developmental anomalies...
  62. ncbi Calcitonin expression in rat anterior pituitary gland is regulated by ovarian steroid hormones
    Ya Ping Sun
    Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo 79106, USA
    Endocrinology 143:4056-64. 2002
    ..These results suggest that pit-CT mRNA expression is regulated by ovarian hormones, and depletion of pit-CT advances their estrous cycle...
  63. ncbi Regulation of vasopressin V1b receptors in the anterior pituitary gland of the rat
    G Aguilera
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA
    Exp Physiol 85:19S-26S. 2000
    ..In addition, the recent characterization of a major part of the V1b receptor gene provides a basis for studying the molecular mechanisms regulating the V1b receptor...
  64. ncbi Seasonal variations of gonadotropins in the pars distalis male viscacha pituitary. Effect of chronic melatonin treatment
    V Filippa
    Catedra de Histologia y Embriologia, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina
    Eur J Histochem 49:291-300. 2005
    ..Moreover, melatonin acts differentially on the activity of the gonadotrope cells...
  65. ncbi Phagocytotic removal of apoptotic endocrine cells by folliculostellate cells and its functional implications in clusterin accumulation in pituitary colloids in helmeted guinea fowl (Numida meleagris)
    Luziga Claudius
    United Graduate School of Veterinary Sciences, Yamaguchi University, 1677 1 Yoshida, Yamaguchi City 753 8515, Japan
    Acta Histochem 108:69-80. 2006
    ..Apoptotic endocrine cells are phagocytosed by FS cells and digested by their lysosomal enzymes. In FS cells, clusterin interacts and aggregates with by-products of digestion that subsequently become stored in colloid as a residual body...
  66. ncbi Endothelin-like immunoreactivity in lactotrophs, gonadotrophs, and somatotrophs of rat anterior pituitary gland are affected differentially by ovarian steroid hormones
    B Kanyicska
    Department of Biological Science, Florida State University, Tallahassee 32306 4340, USA
    Endocrine 14:263-8. 2001
    ....
  67. ncbi Estrogen regulation of the rat anterior pituitary gland proteome
    Charles A Blake
    Department of Cell and Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Exp Biol Med (Maywood) 230:800-7. 2005
    Estrogen is known to affect the regulation of all six of the established anterior pituitary gland (AP) hormones, but little is known of the specifics of its regulation of the AP hormones, their isoforms, and nonhormonal AP proteins...
  68. ncbi ACTH cells of pituitary pars distalis of viscacha (Lagostomus maximus maximus): immunohistochemical study in relation to season, sex, and growth
    Verónica Filippa
    Catedra de Histologia y Embriologia, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Av Ejército de los Andes 950 2 Piso 5700 San Luis, Argentina
    Gen Comp Endocrinol 146:217-25. 2006
    ..Moreover, the morphological variations observed between adult and immature male viscachas and between both sexes suggest that the steroid gonadal hormones might act on the development and activity of ACTH cells...
  69. ncbi Localization of interleukin-18 and its receptor in somatotrophs of the bovine anterior pituitary gland
    Yasuhiro Nagai
    Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, 981 8555, Sendai, Japan
    Cell Tissue Res 322:455-62. 2005
    ..this hypothesis by investigating the intracellular localization of IL-18 and its receptor in bovine anterior pituitary gland. IL-18 mRNA and its protein were detected in the anterior pituitary gland by RT-PCR and Western blotting...
  70. ncbi Intercellular communications within the rat anterior pituitary XI: an immunohistochemical study of distributions of S-100 positive cells in the anterior pituitary of the rat
    Goro Sato
    Functional Morphology, Nagoya City University Medical Science, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya City, Aichi 467 8601, Japan
    Tissue Cell 37:269-80. 2005
    ..The distribution pattern of the folliculo-stellate cells and the capillaries showed good agreement and the spatial relationship between these two is detailed so as to better understand hypophyseal histophysiology...
  71. ncbi Antiproliferative action of calcitonin on lactotrophs of the rat anterior pituitary gland: evidence for the involvement of transforming growth factor beta 1 in calcitonin action
    Yong Qing Wang
    Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Endocrinology 144:2164-71. 2003
    ..These results suggest that antiproliferative action of CT on lactotrophs may, at least in part, be mediated by CT-induced TGF-beta 1 expression...
  72. ncbi Cloning of partial cDNAs for the chicken glucocorticoid and mineralocorticoid receptors and characterization of mRNA levels in the anterior pituitary gland during chick embryonic development
    Tom E Porter
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Domest Anim Endocrinol 33:226-39. 2007
    ..Characterization of mRNA levels in the anterior pituitary gland during chick embryonic development by quantitative real time RT-PCR demonstrates decreased MR and ..
  73. ncbi Homologous desensitization with gonadotropin-releasing hormone (GnRH) also diminishes gonadotrope responsiveness to maitotoxin: a role for the GnRH receptor-regulated calcium ion channel in mediation of cellular desensitization
    P M Conn
    Department of Pharmacology, University of Iowa College of Medicine, Iowa City 52242
    Mol Endocrinol 1:154-9. 1987
    ..These data are consistent with a model in which homologous desensitization is viewed as developing in two phases.(ABSTRACT TRUNCATED AT 250 WORDS)..
  74. ncbi Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: possible formation of an ETA-ETB receptor heterodimer
    Noboru Harada
    Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan
    Cell Mol Neurobiol 22:207-26. 2002
    ..ET-1), a typical bivalent ET receptor-ligand, between ETA and ETB receptors was investigated in the rat anterior pituitary gland, using our quantitative receptor autoradiographic method with tissue sections preserving the cell-..
  75. pmc P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development
    D P Szeto
    Biomedical Sciences Graduate Program, Howard Hughes Medical Institute, University of California, San Diego 92093 0648, USA
    Proc Natl Acad Sci U S A 93:7706-10. 1996
    ..Therefore, P-OTX may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs.
  76. ncbi Cocaine- and amphetamine-regulated transcript co-contained in thyrotropin-releasing hormone (TRH) neurons of the hypothalamic paraventricular nucleus modulates TRH-induced prolactin secretion
    Stefanos Raptis
    Neuroendocrine Research Laboratory, Semmelweis University, Budapest, Hungary
    Endocrinology 145:1695-9. 2004
    ..of the hypothalamic paraventricular nucleus (PVN) stimulates the release of TSH and prolactin from the anterior pituitary gland. Recent data from our laboratories have demonstrated that TRH and cocaine- and amphetamine-regulated ..
  77. ncbi Daily profiles of plasma prolactin (PRL), growth hormone (GH), insulin-like growth factor-1 (IGF-1), luteinizing hormone (LH), testosterone, and melatonin, and of pituitary PRL mRNA and GH mRNA in male Long Evans rats in acute phase of adjuvant arthritis
    Olha Roman
    Department of Normal, Pathological, and Clinical Physiology, Third Medical Faculty of Charles University, Prague, Czech Republic
    Chronobiol Int 20:823-36. 2003
    ..The persistence of a distinct melatonin rhythm in AA suggests the observed disturbances of hormonal rhythms in this condition do not occur at the level of the pineal gland...
  78. ncbi Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals
    Naoya Masutomi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, 158 8501 Tokyo, Japan
    Arch Toxicol 78:232-40. 2004
    ..The difference in the pituitary effect between MXC and EE is discussed...
  79. ncbi Role of hypothalamic inputs in maintaining pituitary-adrenal responsiveness in repeated restraint
    D Zelena
    Laboratory of Stress Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1450 Budapest, Hungary
    Am J Physiol Endocrinol Metab 285:E1110-7. 2003
    ..PVH seems to be important for the repeated restraint-induced ACTH and POMC mRNA stimulation, but it appears to partially mediate other restraint-induced hormonal changes...
  80. ncbi Endotoxin at low doses stimulates pituitary GH whereas it decreases IGF-I and IGF-binding protein-3 in rats
    T Priego
    Departamento Fisiologia, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    J Endocrinol 179:107-17. 2003
    ..The decrease in liver IGFBP-3 mRNA and in serum concentrations of IGFBP-3 in the rats injected with LPS may contribute to the decrease in serum concentrations of IGF-I...
  81. ncbi Proliferating cells in the rat anterior pituitary during the postnatal period: immunoelectron microscopic observations using monoclonal anti-bromodeoxyuridine antibody
    Rieko Kominami
    Department of Anatomy, Kanazawa Medical University, Uchinada, 920 0293 Ishikawa, Japan
    Histochem Cell Biol 120:223-33. 2003
    ..These results suggest: (1) the majority of proliferating cells were mature cells producing anterior pituitary hormone(s) and (2) most of the agranular proliferating cells maybe FS cells. The possibility of the latter is discussed...
  82. pmc Fasting and glucose effects on pituitary leptin expression: is leptin a local signal for nutrient status?
    Christopher Crane
    Department of Neurobiology and Developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham 510, Little Rock, AR 72205, USA
    J Histochem Cytochem 55:1059-73. 2007
    ..Collectively, the findings suggest that pituitary leptin expression could be coupled to glucose sensors like glucokinase to facilitate rapid responses by the neuroendocrine system to nutritional cues...
  83. ncbi Estrogen Induces Neuropeptide Y (NPY) Y1 receptor gene expression and responsiveness to NPY in gonadotrope-enriched pituitary cell cultures
    Jennifer W Hill
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Endocrinology 145:2283-90. 2004
    ..The biological importance of E(2)'s opposite effects on Y1R expression in other pituitary cell types remains to be determined...
  84. ncbi Dehydroepiandrosterone (DHEA) modulates GHRH, somatostatin and angiotensin II action at the pituitary level
    C Suarez
    Instituto de Biologia y Medicina Experimental, CONICET, V, Obligado 2490, Buenos Aires 1428, Argentina
    J Endocrinol 185:165-72. 2005
    ..These effects could help explain some of the side effects observed in prolonged DHEA treatments in vivo and should be taken into account when considering its use in human clinical trials...
  85. ncbi GABA(B1) knockout mice reveal alterations in prolactin levels, gonadotropic axis, and reproductive function
    Paolo N Catalano
    Instituto de Biologia y Medicina Experimental CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neuroendocrinology 82:294-305. 2005
    ..The molecular mechanism underlying these hormonal disturbances remains to be addressed...
  86. ncbi Distribution of immunoreactive adenohypophysial cell types in the pituitaries of the Atlantic and the Pacific hagfish, Myxine glutinosa and Eptatretus burgeri
    Masumi Nozaki
    Sado Marine Biological Station, Niigata University, Tassha, Sado, Niigata 952 2135, Japan
    Gen Comp Endocrinol 143:142-50. 2005
    ..Based on these findings, we suggest that hagfish may have retained ancestral characteristics of key anterior pituitary hormones...
  87. ncbi Relationship between pituitary and adipose tissue after hypothalamic denervation in the female rat. A morphometric immunohistochemical study
    Gisela Camihort
    Department of Cytology, Histology and Embryology B, School of Medicine, National University of La Plata, UNLP and CICBA, La Plata, Argentina
    Cells Tissues Organs 179:192-201. 2005
    ....
  88. ncbi Effects of 8-prenylnaringenin on the hypothalamo-pituitary-uterine axis in rats after 3-month treatment
    J Christoffel
    Division of Clinical and Experimental Endocrinology, Department of Obstetrics and Gynecology, University of Gottingen, Robert Koch Str 40, 37099 Gottingen, Germany
    J Endocrinol 188:397-405. 2006
    ..Human pharmacologic studies will show whether the stimulatory effect on the uterus that was found in the present animal model would require the concomitant administration of progestins to prevent endometrial overstimulation...
  89. ncbi Three-dimensional imaging of the intracellular localization of growth hormone and prolactin and their mRNA using nanocrystal (Quantum dot) and confocal laser scanning microscopy techniques
    Akira Matsuno
    Department of Neurosurgery, Teikyo University Ichihara Hospital 3426 3 Anesaki, Ichihara City, Chiba 299 0111, Japan
    J Histochem Cytochem 53:833-8. 2005
    ..Such an approach enables us to visualize functional images of proteins in relation with mRNA synthesis and localization...
  90. ncbi Stimulation and inhibition of prolactin release by prolactin-releasing Peptide in rat anterior pituitary cell aggregates
    E Swinnen
    Laboratory of Cell Pharmacology, University of Leuven, Medical School, Campus Gasthuisberg, Belgium
    J Neuroendocrinol 17:379-86. 2005
    ..Furthermore, dopamine inhibition of prolactin release is antagonized by PrRP, irrespective of the PrRP dose...
  91. pmc Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion
    Song Guang Ren
    Department of Medicine, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room 2015, Los Angeles, California 90048, USA
    Endocrinology 147:3936-42. 2006
    ..Pyridoxine may therefore be appropriate for testing as a relatively safe drug for adjuvant treatment of hormone-secreting pituitary adenomas...
  92. ncbi Effect of interferon-gamma treatment on 24-hour variations in plasma ACTH, growth hormone, prolactin, luteinizing hormone and follicle-stimulating hormone of male rats
    Pilar Cano
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Espana
    Neuroimmunomodulation 12:146-51. 2005
    ..In this study we measured the circadian pattern of plasma ACTH, growth hormone (GH), prolactin, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) at 6 different time points within a 24-hour cycle in adult male Wistar rats...
  93. pmc Hormonal and morphological study of the pituitaries in reeler mice
    Matilde Lombardero
    Department of Anatomy and A P, Faculty of Veterinary Sciences, University of Santiago de Compostela, Lugo, Spain
    Int J Exp Pathol 88:165-73. 2007
    ....
  94. ncbi Anterior pituitary thyrotropes are multifunctional cells
    Carlos Villalobos
    Dept Fisiología y Bioquímica, Facultad de Medicina, Instituto de Biologia y Genetica Molecular, University of Valladolid, E 47005 Valladolid, Spain
    Am J Physiol Endocrinol Metab 287:E1166-70. 2004
    ..This would limit the appearance of paradoxical secretion under physiological conditions and suggests that timing of hormone and HRH receptor expression during the transdifferentiation process is finely and differentially regulated...
  95. ncbi Biological role of pituitary estrogen receptors ERalpha and ERbeta on progesterone receptor expression and action and on gonadotropin and prolactin secretion in the rat
    Jose E Sanchez-Criado
    Department of Cell Biology, Physiology and Inmunology, University of Cordoba, Cordoba, Spain
    Neuroendocrinology 79:247-58. 2004
    ....
  96. ncbi Effects of p-nonylphenol and 4-tert-octylphenol on the anterior pituitary functions in adult ovariectomized rats
    Miyako Furuta
    Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Neuroendocrinology 84:14-20. 2006
    ..The present study suggests that NP, even with a single injection, suppresses the pulsatile LH secretion in adult ovariectomized rats, probably by affecting the anterior pituitary level...
  97. ncbi Regulation of pituitary cell function by adiponectin
    Francisca Rodriguez-Pacheco
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, E 14014 Cordoba, Spain
    Endocrinology 148:401-10. 2007
    ..In sum, our data indicate that adiponectin, either locally produced or from other sources, may play a neuroendocrine role in the control of both somatotrophs and gonadotrophs...
  98. ncbi Estradiol induces expression of 5-hydroxytryptamine (5-HT) 4, 5-HT5, and 5-HT6 receptor messenger ribonucleic acid in rat anterior pituitary cell aggregates and allows prolactin release via the 5-HT4 receptor
    A Papageorgiou
    Laboratory of Cell Pharmacology, University of Leuven, Medical School, Campus Gasthuisberg O and N, B 3000 Leuven, Belgium
    Endocrinology 148:1384-95. 2007
    ..The present data suggest a widespread expression of 5-HTRs in the rat anterior pituitary, several of which are up-regulated by estrogen, and that, in the presence of estrogen, one of these, the 5-HTR4, mediates acute PRL release...
  99. ncbi In vivo and in vitro effects of chromium VI on anterior pituitary hormone release and cell viability
    Fernanda A Quinteros
    Departamento de Quimica Biologica, IQUIFIB, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956 Buenos Aires C1113AAD, Argentina
    Toxicol Appl Pharmacol 218:79-87. 2007
    ..Our results indicate that the anterior pituitary gland can be a target of Cr VI toxicity in vivo and in vitro, thus producing a negative impact on the ..
  100. ncbi Cross-talk between the estrogen receptor-, protein kinase A-, and mitogen-activated protein kinase-mediated signaling pathways in the regulation of lactotroph proliferation in primary culture
    Koji Yamakawa
    Department of Physiology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Tamaho, Nakakoma, Yamanashi 409 3898, Japan
    J Steroid Biochem Mol Biol 88:123-30. 2004
    ....
  101. ncbi Intermedin/Adrenomedullin-2 inhibits growth hormone release from cultured, primary anterior pituitary cells
    Meghan M Taylor
    Saint Louis University, Pharmacological and Physiological Science, Missouri 63104, USA
    Endocrinology 147:859-64. 2006
    ..Because AM, CGRP, and AMY have been reported to affect hormone secretion from the anterior pituitary gland, we examined the effects of IMD on GH, ACTH, and prolactin secretion from dispersed anterior pituitary ..

Research Grants62

  1. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ..activity of CRH neurons at the level of the PVN as well as enhancing CRH secretogogue activity at the anterior pituitary gland. The reproductive steroids, E and T can also modulate stress responses...
  2. Growth hormone and adult physiology
    Rhonda D Kineman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Growth hormone (GH) is produced by somatotropes of the anterior pituitary gland and is released into the general circulation where it stimulates the production of insulin-like growth factor I (IGF-I) ..
  3. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    ..After birth, leptin levels rise just before gonadotropes and somatotropes, cells of the anterior pituitary gland that produce hormones essential for reproduction, grow in number and reach adult levels by age 10-15 days...
  4. Role of LHX3 Protein Isoforms in Pituitary Development
    SIMON JAMES RHODES; Fiscal Year: 2012
    ..The anterior pituitary gland secretes polypeptide hormones that are critical for many aspects of human development and physiology, ..
  5. Physiological Mechanisms Underlying Heightened Responsiveness of Gonadotropes to
    Colin M Clay; Fiscal Year: 2013
    ..events in reproduction and requires a dramatic surge of luteinizing hormone (LH) released by the anterior pituitary gland into the peripheral circulation...
  6. ROLE OF PACAP IN THE MALE FETAL PITUITARY
    Joseph P Moore; Fiscal Year: 2011
    ..pituitary products and endocrine hormones confer the high level of PACAP gene expression within the fetal anterior pituitary gland 4) Confirm the importance of PACAP on gonadotroph development by analyses of the affects of PACAP ..
  7. Homeodomain Repressor Msx1 in Gonadotrope Differentiation
    Huimin Xie; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Proper development and function of the anterior pituitary gland is critical for multiple physiological processes including growth, metabolism and reproduction...
  8. GALANIN REGULATION OF PITUITARY REPRODUCTIVE HORMONES
    ANGELA BAUER DANTOIN; Fiscal Year: 1999
    ..2 are designed to characterize the galanin receptor subtype that is expressed in gonadotropes in the anterior pituitary gland. Double-label in situ hybridization experiments will be performed to determine if galanin type 2 receptor ..
  9. ESTOGENS, DIETARY ENERGY AND PITUITARY TUMORIGENESIS
    James Shull; Fiscal Year: 2002
    ..The prolactin (PRL)-producing lactotroph of the rat anterior pituitary gland provides a valuable model for studying regulation of cell proliferation by estrogens...
  10. Mouse model of adult-onset, isolated, GH-deficiency
    RHONDA KINEMAN; Fiscal Year: 2009
    ..mouse line that expresses Cre recombinase (Cre) in the GH-producing cells (somatotropes) of the anterior pituitary gland (rGHp-Cre)...
  11. BRAIN MONOAMINES AND LUTEINIZING HORMONE SECRETION
    William Crowley; Fiscal Year: 2003
    ..neuropeptide systems that regulate the secretion of luteinizing hormone (LH) and prolactin (PRL) from the anterior pituitary gland in response to physiological stimuli...
  12. Thyrotrope Proliferation by Thyroid Hormone
    ELI RIDGWAY; Fiscal Year: 2006
    DESCRIPTION: (Provided By Applicant) The anterior pituitary gland is a small structure located at the base of the brain...
  13. REGULATION OF PITUITARY HYPERPLASIA AND NEOPLASIA
    Ricardo Lloyd; Fiscal Year: 1999
    ..The role of folliculo-stellate cells which have putative paracrine functions in the anterior pituitary gland will be examined by isolating enriched populations of folliculo-stellate cells using flow cytometric cell ..
  14. PIT-1T AND THYROTROPIN BETA SUBUNIT GENE EXPRESSION
    BRYAN HAUGEN; Fiscal Year: 1999
    The anterior pituitary gland contains at least five terminally differentiated cell types, which includes somatotropes, lactotropes, thyrotropes, corticotropes, and gonadotropes...
  15. ANGIOTENSIN II IN ENDOCRINE ORGANS
    Christian Deschepper; Fiscal Year: 1991
    ..endocrine organs where there is strong evidence for local renin- angiotensin systems (RAS), namely, the anterior pituitary gland, the adrenal cortex and the testicular Leydig cells in the rat...
  16. EFFECTS OF AGING ON THE REGULATION OF FSH SECRETION
    LOUIS DE PAOLO; Fiscal Year: 1990
    ..Furthermore, the type of FSH produced by the anterior pituitary gland (AP) seemingly is affected by the aging process of both species in that the AP's of older rats and humans ..
  17. PITUITARY TUMOR CELL CULTURES
    Shlomo Melmed; Fiscal Year: 1991
    Each of the cell types of the anterior pituitary gland may give rise to adenomas which hypersecrete specific hormones, including prolactin (PRL), growth hormone (GH), adrenocorticotropin (ACTH) glycoprotein hormones or their subunits...
  18. FUNCTIONAL MAPPING OF NEUROENDOCRINE SYSTEMS
    Stephen Sagar; Fiscal Year: 1992
    ..These neurons control ACTH secretion from the anterior pituitary gland and participate in the response to environmental stress...
  19. MECHANISMS IN THE REGULATION OF PROLACTIN SECRETION
    KAREN GREGERSON; Fiscal Year: 1992
    Secretion of prolactin in the mammalian anterior pituitary gland is subject to continual modification by a variety of hormones and neurotransmitters...
  20. REGULATION OF GNRH RECEPTOR GENE EXPRESSION
    Colin Clay; Fiscal Year: 2004
    ..hormone (GnRH) to specific, high-affinity receptors located on gonadotrope cells of the anterior pituitary gland is central to reproduction...
  21. FACTORS REGULATING SYNTHESIS AND SECRETION OF LH AND FSH
    TORRANCE NETT; Fiscal Year: 1992
    ..which pulses of GnRH are administered affects the rate of accumulation of luteinizing hormone (LH) in the anterior pituitary gland; 3) physiological concentrations of estradiol differentially regulate mRNAs for subunits of gonadotropins ..
  22. REGULATION OF GNRH SECRETION DURING SEXUAL MATURATION
    Mark Wise; Fiscal Year: 1992
    ..have been devised for monitoring hypothalamic release of GnRH and direct effects of gonadal steroids on anterior pituitary gland secretion of gonadotropins during this critical period of development...
  23. Regulation and function of Egr in gonadotropes.
    Michael Wolfe; Fiscal Year: 2007
    ..provided by applicant): Luteinizing hormone (LH) is synthesized and secreted by gonadotropes within the anterior pituitary gland and is composed of an alpha- and LHbeta-subunit...
  24. NEURAL AND HUMORAL CONTROL OF ENDOCRINE FUNCTION
    Ian Reid; Fiscal Year: 1992
    ..explores the function of the brain renin-angiotensin system in the regulation of the secretion of the anterior pituitary gland. The fifth protect (P.I.: T.L...
  25. MOLECULAR BASIS OF HYPOPITUITARISM IN MAN
    LAURIE COHEN; Fiscal Year: 1999
    ..Equally important- functional studies of these mutations will increase the understanding of anterior pituitary gland development and gene regulation in man.
  26. HYPOPITUITARISM: CLINICAL & MOLECULAR CHARACTERIZATION
    Sally Radovick; Fiscal Year: 2004
    ..factors and their diverse pathophysiological mechanisms should increase our understanding of anterior pituitary gland development and gene regulation in normal and disease states...
  27. ECTOPIC EXPRESSION OF THE RETINOBLASTOMA GENE IN MICE
    STEPHEN HEDRICK; Fiscal Year: 1993
    ..lines that show high levels of expression will be analyzed for the development of beta-islet cells, the anterior pituitary gland, and the thymus, respectively...
  28. SPECIFICITIES OF HOMEODOMAIN PROTEINS IN DEVELOPMENT
    Aneel Aggarwal; Fiscal Year: 2004
    ..Pit-1 is expressed exclusively in the anterior pituitary gland. Many of the mutations causing combined pituitary hormone deficiency in humans have been mapped to Pit-1...
  29. GNRH ANALOG TOXINS FOR TARGETED GONADOTROPH ABLATION
    L Glode; Fiscal Year: 2000
    ..of a toxic protein to a GnRH superagonist that will specifically deliver the toxin to gonadotrophs in the anterior pituitary gland. The toxin then destroys the gonadotrophs resulting in cessation of gonadal function...
  30. Mechanisms of Pituitary Development
    GARY SCHOENWOLF; Fiscal Year: 2007
    ..Studies on the origin and patterning mechanisms of the early presumptive adenohypophysis (anterior pituitary gland) in chick and other model systems, prior to formation of Rathke's pouch (the pituitary anlage), are ..
  31. NPY BIOSYNTHESIS AND SECRETION IN THE HYPOTHALAMUS
    JOHN MC DONALD; Fiscal Year: 1993
    ..fragments, push-pull perfusion and microdialysis of the medial basal hypothalamus, microdialysis of the anterior pituitary gland, and collection of pituitary portal blood. 2...
  32. NEUROHUMORAL CONTROL OF ANTERIOR PITUITARY
    Samuel McCann; Fiscal Year: 1993
    ..against the peptides or peptide antagonists; and (5) studies on receptors for brain peptides in the anterior pituitary gland. All of these studies will enhance our knowledge of the hypothalamic control of the adenohypophysis...
  33. ROLE OF RETINOIDS AND RECEPTORS IN THYROTROPE FUNCTION
    BRYAN HAUGEN; Fiscal Year: 2004
    ..appears to require the RXRgamma isoform, which has expression limited to the thyrotropes within the anterior pituitary gland. The goals of this proposal are to define the specific mechanisms governing the effect of retinoids on ..
  34. GONADOTROPHIC HORMONES IN MALNOURISHED RATS
    DAMON HERBERT; Fiscal Year: 1980
    ..Light and electron microscopic analyses of the anterior pituitary gland, sex accessory organs and gonads will also be conducted...
  35. NICOTINE AND DEVELOPMENT OF THE ANTERIOR PITUITARY
    CHARLES BLAKE; Fiscal Year: 1990
    Previous investigations have shown injection of nicotine into rats to have acute effects on anterior pituitary gland (APG) hormone release...
  36. Treatment of Crohn's Disease with Growth Hormone
    Tamara Hannon; Fiscal Year: 2006
    ..GHRH is a peptide that stimulates the synthesis and secretion of GH from the somatotrope cells of the anterior pituitary gland and is used therapeutically in some GH deficient patients...
  37. MOLECULAR ANALYSIS OF THE PITUITARY GHRH RECEPTOR
    Kelly Mayo; Fiscal Year: 2003
    ..between the nervous and endocrine systems by controlling the activity of specific target cells in the anterior pituitary gland. The hypothalamic peptide growth hormone-releasing hormone (GHRH) acts on pituitary somatotroph cells to ..
  38. NEGATIVE FEEDBACK OF STEROIDS ON LH AND FSH IN RATS
    Vernon Gay; Fiscal Year: 1980
    While it is clear that the secretions of the testis are adequate to inhibit gonadotropin secretions by the anterior pituitary gland, the contributions of the various circulating steroid (and non-steroid) compounds to this process are not ..
  39. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010
    ..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..
  40. Orexinergic Pathways in Central Autonomic Control
    WILLIS SAMSON; Fiscal Year: 2005
    ..abstract_text> ..
  41. GENOMICS OF GnRH PRIMING
    JUDITH TURGEON; Fiscal Year: 2005
    ....
  42. LH Secretion Mechanisms
    JUDITH TURGEON; Fiscal Year: 2006
    ..Cell models will be cultured gonadotropes from rats and wild-type and PR-knockout (PRKO) mice and the LbetaT2 gonadotrope cell line. ..
  43. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK SARKAR; Fiscal Year: 2009
    ....
  44. Biology of the NK cell cytolytic activity rhythm
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..The proposed series of studies should enhance our knowledge of the physiological mechanisms orchestrating NK cell circadian function. ..
  45. Fetal Alcohol Effects on Circadian clocks and POMC
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..This information should help to develop therapeutic strategies in managing sleep-wake disturbances and the resultant health consequences in FAE offspring. ..
  46. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ..AVP signals act individually and jointly to stimulate ACTH synthesis, accumulation and secretion by the anterior pituitary gland. Systemic ACTH concentrations in turn drive adrenal cortisol secretion via a time-lagged feedforward dose-..
  47. ESTROGEN MITOGENIC ACTION IN THE PITUITARY
    DIPAK SARKAR; Fiscal Year: 2003
    ..Such knowledge should be important in understanding prolactinoma because increased proliferation is an early step in cell transformation. ..
  48. OPIOID AND ALCOHOL REGULATED IMMUNE FUNCTION
    DIPAK SARKAR; Fiscal Year: 2002
    ....
  49. CONSTRUCTION OF BIOLOGY RESEARCH FACILITY
    DIPAK SARKAR; Fiscal Year: 2002
    ..abstract_text> ..
  50. RESPONSIVENESS OF GNRH RECEPTOR SIGNALING
    JIMMY NEILL; Fiscal Year: 2002
    ..GRKs 2, 3, and 5 and beta arrestin 1 and 2 are expressed naturally in the rat anterior pituitary gland, and their experimental expression in GnRH receptor expressing COS-1 cells suppresses GnRH-stimulated ..
  51. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  52. SYNTHETIC SUBSTANCES CONTROLLING REPRODUCTION
    Jean Rivier; Fiscal Year: 2005
    ..Such molecules are not presently available to academic researchers. As in the past twenty years, collaborations with academic colleagues will be initiated, to maximize the impact of this research. ..
  53. Somatostatin Receptor-Selective Agonists and Antagonists
    Jean Rivier; Fiscal Year: 2006
    ..abstract_text> ..
  54. Cellular Basis for Non-Parallel Gonadotropin Release
    Gwen Childs; Fiscal Year: 2005
    ..An understanding of mechanisms that selectively regulate gene expression in these cells will provide important information about how fertility is regulated. ..
  55. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  56. Regulation of Leptin Production by Gonadotropes
    Gwen Childs; Fiscal Year: 2005
    ..These feasibility studies will thus provide information that will allow us to design future experiments for full funding. ..
  57. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  58. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  59. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  60. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
  61. Antioxidant Defense System and Leydig Cell Aging
    Haolin Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..