Genomes and Genes
Summary: Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.
Publications260 found, 100 shown here
- Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroidE M Brown
Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
Nature 366:575-80. 1993....
- Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patientsHirotaka Komaba
Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
Kidney Int 77:232-8. 2010..b>Parathyroid glands express both FGFR1 and Klotho, and FGF23 decreases parathyroid hormone gene expression and hormone secretion ..
- Subtotal parathyroidectomy as an adequate treatment for primary hyperparathyroidism in multiple endocrine neoplasia type 1Johnathan G H Hubbard
Department of Endocrine Surgery, University Hospital La Timone, Marseille, France
Arch Surg 141:235-9. 2006..In view of our large experience in patients with secondary HPT for whom TP with autotransplantation did not simplify reoperations, SP remains our preferred treatment for patients with HPT and multiple endocrine neoplasia type 1...
- Ultrasound of the thyroid and parathyroid glandsNadia Khati
Department of Radiology, The George Washington University, Washington, DC 20037, USA
Ultrasound Q 19:162-76. 2003..In patients in whom the studies do not agree or in whom they do not detect the adenoma, further evaluation with CT or more preferably MRI is indicated...
- FGF23 and the parathyroid glandsJustin Silver
Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem, 91120, Israel
Pediatr Nephrol 25:2241-5. 2010..Klotho-FGFR1c is also expressed in the parathyroid glands. FGF23 acts on the receptor complex in the parathyroid glands to decrease parathyroid hormone (PTH) gene ..
- FGF23 fails to inhibit uremic parathyroid glandsRocio Canalejo
Unidad de Investigacion, Servicio de Nefrologia, Departamento de Medicina, Red in ren, Instituto Maimó nides de Invstigación Biomédica de Córdoba, Hospital Universitario Reina Sofia, Cordoba, Spain
J Am Soc Nephrol 21:1125-35. 2010..Here, we investigated the effect of FGF23 on parathyroid function in normal and uremic hyperplastic parathyroid glands in rats...
- Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic optionsJohn Cunningham
Centre for Nephrology, UCL Medical School, Royal Free Campus, London, United Kingdom
Clin J Am Soc Nephrol 6:913-21. 2011..Future strategies may focus on the stimulation of apoptotic activity of hyperplastic parathyroid cells...
- Pharmacodynamics of the type II calcimimetic compound cinacalcet HClEdward F Nemeth
Amgen, Inc, Thousand Oaks, CA 91320 1799, USA
J Pharmacol Exp Ther 308:627-35. 2004..The present findings provide compelling evidence that cinacalcet HCl is a potent and stereoselective activator of the parathyroid CaR and, as such, might be beneficial in the treatment of hyperparathyroidism...
- Cinacalcet effectively reduces parathyroid hormone secretion and gland volume regardless of pretreatment gland size in patients with secondary hyperparathyroidismHirotaka Komaba
Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
Clin J Am Soc Nephrol 5:2305-14. 2010..However, it has not been proven whether parathyroid gland size predicts response to therapy and whether cinacalcet is capable of inducing a reduction in parathyroid volume...
- Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiologyTomer Meir
Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hospital, Jerusalem, Israel
Am J Physiol Renal Physiol 297:F1192-8. 2009..The sensitivity of the parathyroid glands of the PT-VDR(-/-) mice to calcium was intact as measured by serum PTH levels after changes in serum calcium...
- The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic ratsMario Cozzolino
Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
J Am Soc Nephrol 13:2299-308. 2002..These findings cannot be extrapolated to human disease, and further studies in patients are necessary to determine the benefits of either P binder...
- Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidismMario Meola
Department of Internal Medicine, S Anna School of Advanced Studies, Nephrology and Dialysis Unit, University of Pisa, Italy
Nephrol Dial Transplant 24:982-9. 2009The effect of cinacalcet on the structural pattern of hyperplastic parathyroid glands was evaluated, using high-resolution colour Doppler (CD) sonography, in haemodialysis patients with severe, inadequately controlled, secondary ..
- Primary hyperparathyroidism: a current perspectiveRonald A DeLellis
Department of Pathology, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
Arch Pathol Lab Med 132:1251-62. 2008..Additionally, imaging studies and the development of the intraoperative assay for parathyroid hormone have transformed the diagnosis and management of patients with these disorders...
- Pathogenesis of parathyroid hyperplasia in renal failureMario Cozzolino
Renal Division, San Paolo Hospital, Milan Italy
J Nephrol 18:5-8. 2005..In this review, we analyze the current understanding concerning the new insights into the molecular mechanisms of parathyroid hyperplasia and PTH secretion in renal failure regulated by calcium, phosphate and vitamin D...
- alpha-Klotho as a regulator of calcium homeostasisAkihiro Imura
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
Science 316:1615-8. 2007..Our findings reveal fundamental roles of alpha-Kl in the regulation of calcium metabolism...
- Ultrasonography in detection of single and multiple abnormal parathyroid glands in primary hyperparathyroidism: comparison with radionuclide scintigraphy and surgeryA Bhansali
Endocrinology and Metabolism, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Clin Endocrinol (Oxf) 65:340-5. 2006..Among the parathyroid imaging techniques, ultrasonography (USG) has the advantage of convenience, easy availability and low cost...
- FGF23-parathyroid interaction: implications in chronic kidney diseaseHirotaka Komaba
Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
Kidney Int 77:292-8. 2010..resistance to FGF23 may be caused by decreased expression of Klotho-FGFR1 complex in hyperplastic parathyroid glands. This review summarizes recent insights into the role of FGF23 in mineral homeostasis and discusses the ..
- 25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glandsUlrika Segersten
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
J Clin Endocrinol Metab 87:2967-72. 2002..The findings imply that in addition to feedback control by circulating 1,25(OH)(2)D(3) levels, parathyroid cells may also be influenced by local 1alpha -hydroxylase activity with possible growth regulatory and differentiating effects...
- Radionuclide imaging of the parathyroid glandsChristopher J Palestro
Department of Nuclear Medicine and Radiology, Albert Einstein College of Medicine, Bronx, NY, USA
Semin Nucl Med 35:266-76. 2005The parathyroid glands, which usually are situated behind the thyroid gland, secrete parathyroid hormone, or PTH, which helps maintain calcium homeostasis. Primary hyperparathyroidism results from excess parathyroid hormone secretion...
- Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5O Chisaka
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
Nature 350:473-9. 1991..In addition, they often feature defects of the heart and arteries as well as craniofacial abnormalities. These deficiencies are remarkably similar to the pathology of the human congenital disorder DiGeorge's syndrome...
- Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndromeWilliam F Simonds
Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 89:96-102. 2004..Even accounting for families with one of the three occult syndromes and false negative biochemical or DNA testing, these results indicate that an unexpectedly large fraction of FIHP has currently unrecognized causes...
- Virtual neck exploration: a new method for localizing abnormal parathyroid glandsRupert Prommegger
Department of Operative Medicine, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Ann Surg 250:761-5. 2009..The aim of this study was to evaluate whether CT-MIBI-SPECT image fusion is superior to MIBI-SPECT and CT in detecting abnormal parathyroid glands in patients with primary hyperparathyroidism.
- Hoxa3 and pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesisD Su
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
Dev Biol 236:316-29. 2001The thymus and parathyroid glands in mice develop from a thymus/parathyroid primordium that forms from the endoderm of the third pharyngeal pouch...
- Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissueMing Lu
Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Mol Cell Endocrinol 287:72-80. 2008..1micromol/l). SNAP-25 (and Syntaxin1) appears to be a tumour-specific protein(s) in parathyroid tissues since its expression was restricted to pathological tissues...
- Influence of donor MHC class I antigen expression on graft survival after rat parathyroid allotransplantationS Timm
Department of Surgery, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Langenbecks Arch Surg 386:430-3. 2001..We investigated the influence of donor MHC antigen expression on graft survival after parathyroid transplantation in three different strain combinations...
- Expression of cellular retinol- and retinoic acid-binding proteins in normal and pathologic human parathyroid glandsH Melhus
Department of Medical Sciences, Uppsala University Hospital, S 751 85 Uppsala, Sweden
Endocr Pathol 12:423-7. 2001..In the present study, we identified Ito-like cells in parathyroid glands, suggesting local stores of vitamin A...
- Surgical anatomy of the thyroid and parathyroid glandsFrank R Miller
Department of Otolaryngology Head and Neck Surgery, University of Texas Health Science Center, 7703 Floyd Curl Drive, Code 7777, San Antonio, San Antonio, TX 78248, USA
Otolaryngol Clin North Am 36:1-7, vii. 2003..These critical structures include the recurrent laryngeal nerves, the superior laryngeal nerves, and the parathyroid glands. Successful thyroid surgery depends on the technical skill of the surgeon to identify and preserve these ..
- Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenomaMing Lu
Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital L1 03, SE 171 76 Stockholm, Sweden
J Endocrinol 208:31-9. 2011..Taken together, these results show that calmodulin negatively contributes to the regulation of PTH secretion in parathyroid adenoma, at least partially via a CaMKII pathway...
- Successful implant of long-term cryopreserved parathyroid glands after total parathyroidectomyFábio Luiz de Menezes Montenegro
Department of Head and Neck Surgery, University of Sao Paulo Medical School, Sao Paulo, Brazil
Head Neck 29:296-300. 2007..Parathyroid cryopreservation is essential in some cases of parathyroid surgery. The fate of autografted tissue after long-term cryopreservation is not fully discussed in the literature...
- Xenotransplantation of parathyroids in rats using barium-alginate and polyacrylic acid multilayer microcapsulesA Gaumann
, , Germany
Exp Toxicol Pathol 53:35-43. 2001..In contrast minced tissue underwent necrosis and induced significantly more connective tissue reaction than single cells indicating an interrelationship between necrosis and fibrosis...
- Presurgical localization of abnormal parathyroid glands using a single injection of Tc-99m sestamibi: comparison of high-resolution parallel-hole and pinhole collimators, and interobserver and intraobserver variationAnne Kirstine Arveschoug
Department of Clinical Physiology, Aalborg Hospital, DK 9100 Aalborg, Denmark
Clin Nucl Med 27:249-54. 2002Scintigraphy using Tc-99m sestamibi is sensitive in localizing abnormal parathyroid glands in patients with hyperparathyroid disease (HPT)...
- Primary hyperparathyroidism in MEN 1--how radical should surgery be?Johnathan G H Hubbard
Department of Endocrine Surgery, University Hospital La Timone, Boulevard Jean Moulin, 13385 Marseilles Cedex 5, France
Langenbecks Arch Surg 386:553-7. 2002..As radical as surgery is for hyperparathyroidism in MEN 1, the surgeon must take steps to avoid permanent hypoparathyroidism, which in young patients may be worse than the disease itself...
- Number of enlarged parathyroid glands might be a predictor of cinacalcet response in advanced secondary hyperparathyroidismMasahiro Yamamoto
Department of Internal Medicine, Showa University Northern Yokohama Hospital, 35 1 Chigasaki chuo, Tsuzuki, Yokohama, Kanagawa, 2248503, Japan
Clin Exp Nephrol 16:292-9. 2012..We investigated clinical factors influencing therapeutic response to cinacalcet for SHPT refractory to active vitamin D sterols...
- Parathyroid hormone without parathyroid glandsRobert Gensure
Endocrinology 146:544-6. 2005
- The calcimimetic R-568 increases vitamin D receptor expression in rat parathyroid glandsM E Rodriguez
Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
Am J Physiol Renal Physiol 292:F1390-5. 2007..In vitro studies of the effect of R-568 on VDR mRNA and protein were conducted in cultures of whole rat parathyroid glands and human hyperplastic parathyroid glands...
- The calcimimetic AMG 641 abrogates parathyroid hyperplasia, bone and vascular calcification abnormalities in uremic ratsCharles Henley
Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, CA 91320, USA
Eur J Pharmacol 616:306-13. 2009..These results suggest that calcimimetics can reduce the development of vascular calcification, parathyroid hyperplasia and bone abnormalities associated with secondary hyperparathyroidism...
- Treatment of osteoporosis with TheraCyte-encapsulated parathyroid cells: a study in a rat modelF F Chou
Department of General Surgery, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung University 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan, Republic of China
Osteoporos Int 17:936-41. 2006....
- Familial isolated hyperparathyroidism maps to the hyperparathyroidism-jaw tumor locus in 1q21-q32 in a subset of familiesB T Teh
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
J Clin Endocrinol Metab 83:2114-20. 1998..Taken together, the results suggest that some of the FIHP are a variant of HPT-JT and that the gene involved is a tumor suppressor gene...
- Selected markers of proliferation and apoptosis in the parathyroid lesions: a spatial visualization and quantificationElzbieta Kaczmarek
Department of Pathomorphology, University of Medical Sciences in Poznan, Przybyszewski Str 49, 60355, Poznan, Poland
J Mol Histol 39:509-17. 2008....
- Parathyroid hormone 7-84 induces hypocalcemia and inhibits the parathyroid hormone 1-84 secretory response to hypocalcemia in rats with intact parathyroid glandsJinxing Huan
Nephrological Department P, Rigshospitalet, Herlev Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
J Am Soc Nephrol 17:1923-30. 2006..calcium-sensing receptor (CaR), PTH type 1 receptor (PTHR1), and PTH-related peptide (PTHrP) genes in rat parathyroid glands. PTH 7-84 induced a significant decrease in plasma Ca2+ in rats with intact parathyroid glands...
- [Functional results of parathyroid autotransplantation in one single pocket for treatment of secondary hyperparathyroidism]Caio Tosato Caliseo
Laboratório de Investigação Médica 28, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR
Rev Col Bras Cir 38:85-9. 2011..To evaluate the operation and surgical time of autotransplanted parathyroid in a single site comparing it to the implant performed in five and twenty locations...
- Distribution and regulation of the 25-hydroxyvitamin D3 1α-hydroxylase in human parathyroid glandsCynthia S Ritter
Renal Division, Washington University School of Medicine, St Louis, MO 63110, United States
J Steroid Biochem Mol Biol 130:73-80. 2012b>Parathyroid glands express the 25-hydroxyvitamin D(3) 1α-hydroxylase (1αOHase)...
- Characterization of heparanase from a rat parathyroid cell lineKatarzyna A Podyma-Inoue
Division of Biochemistry, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8459, Japan
J Biol Chem 277:32459-65. 2002..Further elucidation of the roles of heparanase in normal physiological processes would provide an important tool for analyzing the regulation of heparan sulfate-dependent cell functions...
- Ultrasonography for preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism: comparison with (99m)technetium sestamibi scintigraphyRichard S Haber
Departments of Medicine, Mount Sinai School of Medicine, New York 10029, USA
Clin Endocrinol (Oxf) 57:241-9. 2002To determine the utility of ultrasonography for the preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism, and to compare this method with (99m)technetium sestamibi scintigraphy.
- Short-term immunosuppression after rat parathyroid allotransplantationStephan Timm
Department of Surgery, University of Wurzburg, Wurzburg, Germany
Microsurgery 23:503-7. 2003..Whether the combination of an additional graft pretreatment and immunosuppression has an impact on graft function will be further examined...
- Incidental extirpation of the parathyroid glands at thyroid surgery: risk factors and post-operative hypocalcemiaGhazi Raji Qasaimeh
Department of General Surgery Medical College, King Abdullah University Hospital, Jordan University of Science and Technology, PO Box 1592, Irbid, Jordan
Eur Arch Otorhinolaryngol 268:1047-51. 2011The objective of this study was to estimate the incidence of incidental extirpation of the parathyroid glands during thyroid operations, and to investigate possible risk factors and post-thyroidectomy complications using a descriptive ..
- MR imaging of the thyroid and parathyroid glandsM B Gotway
Department of Radiology, and Cardiovascular Research, University of California, San Francisco School of Medicine, USA
Magn Reson Imaging Clin N Am 8:163-82, ix. 2000..MR imaging of the parathyroid glands is generally used for patients with recurrent or persistent hyperparathyroidism following neck exploration...
- Development of parathyroid gland hyperplasia without uremia: role of dietary calcium and phosphateAntonio Canalejo
Department of Environmental Biology and Public Health, University of Huelva, Huelva, Spain
Nephrol Dial Transplant 25:1087-97. 2010..Methods. We evaluated the functional response of the parathyroid glands in normal rats to different physiological demands an HPD 0.6% Ca, 1.2% P) and LCD 0.2% Ca, 0...
- Microencapsulation of human parathyroid cells: an "in vitro" studyL Picariello
Surgery Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
J Surg Res 96:81-9. 2001..CONCLUSIONS: These findings represent a crucial step toward the construction of functional bioartificial parathyroid organoids for the treatment of hypoparathyroidism in humans...
- Vitamin D-independent therapeutic effects of extracellular calcium in a mouse model of adult-onset secondary hyperparathyroidismKarin Weber
Institute of Animal Physiology, Ludwig Maximilians University, Munich, Germany
J Bone Miner Res 24:22-32. 2009..from the RD to the CD for 2 mo, they developed severe sHPT associated with hypertrophy and hyperplasia of parathyroid glands and profound bone loss...
- Frequency of ectopic and supernumerary intrathymic parathyroid glands in patients with renal hyperparathyroidism: analysis of 461 patients undergoing initial parathyroidectomy with bilateral cervical thymectomyRalph Schneider
Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
World J Surg 35:1260-5. 2011The frequency of intrathymic parathyroid glands (IPGs) in patients undergoing parathyroidectomy for renal hyperparathyroidism (rHPT) varies considerably between 14.8% and 45.3%...
- Resection of ectopic mediastinal parathyroid glands with the da Vinci robotic systemM Ismail
Department of General, Visceral, Vascular and Thoracic Surgery, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Germany
Br J Surg 97:337-43. 2010..Thoracoscopic access is associated with reduced morbidity in mediastinal surgery. The aim of this study was to evaluate the feasibility and effectiveness of robot-assisted dissection for mediastinal ectopic parathyroid glands.
- p21(WAF1) and transforming growth factor-alpha mediate dietary phosphate regulation of parathyroid cell growthA S Dusso
Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Kidney Int 59:855-65. 2001..In addition to reducing p21, high P-induced PT growth could result from increased PT expression of the growth promoter transforming growth factor-alpha (TGF-alpha), known to be elevated in hyperplastic and adenomatous human PT glands...
- Effects of time on ultrastructural integrity of parathyroid tissue before cryopreservationCarlos Eduardo Santa Ritta Barreira
Department of Head and Neck Surgery, University of Sao Paulo Medical School, Sao Paulo, Brazil
World J Surg 35:2440-4. 2011..The present study evaluates the time that the human hyperplastic parathyroid gland tissue can wait before cryopreservation, based on parathyroid cell ultrastructural integrity...
- Near-infrared autofluorescence for the detection of parathyroid glandsConstantine Paras
Vanderbilt University, Department of Biomedical Engineering, VU Station B Box 351631, Nashville, Tennessee 37235, USA
J Biomed Opt 16:067012. 2011A major challenge in endocrine surgery is the intraoperative detection of parathyroid glands during both thyroidectomies and parathyroidectomies...
- Expression and association of TRPC subtypes with Orai1 and STIM1 in human parathyroidMing Lu
Departments of Molecular Medicine and Surgery Oncology Pathology, Karolinska Institutet, Karolinska University Hospital L1 03, 171 76 Stockholm, Sweden
J Mol Endocrinol 44:285-94. 2010..Furthermore, co-immunoprecipitation experiments demonstrated a ternary complex of TRPC1-Orai1-STIM1, supporting a physical interaction between these molecules in human parathyroid...
- High extracellular Ca2+ hyperpolarizes human parathyroid cells via Ca(2+)-activated K+ channelsStiina Välimäki
Department of Molecular Medicine, Karolinska Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
J Biol Chem 278:49685-90. 2003....
- A proteomic approach to study parathyroid glandsLaura Giusti
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, Via, Bonanno 6, 56126 Pisa, Italy
Mol Biosyst 7:687-99. 2011..The functional role of these proteins in the network of intracellular pathways is discussed...
- Natural history of parathyroid function and calcium metabolism after kidney transplantation: a single-centre studyPieter Evenepoel
Department of Medicine, Division of Nephrology, University Hospital Leuven, Belgium
Nephrol Dial Transplant 19:1281-7. 2004..Our aim was to evaluate the post-transplant natural history of parathyroid function and calcium metabolism in patients with a functional renal graft and to identify risk factors for persistent HPT...
- Long-term results of subtotal vs total parathyroidectomy without autotransplantation in kidney transplant recipientsNada Rayes
Department of General, Visceral and Transplant Surgery, Charite Campus Virchow Clinic, Augustenburger Platz 1, 13344 Berlin, Germany
Arch Surg 143:756-61; discussion 761. 2008..Total parathyroidectomy without autotransplantation in kidney transplant recipients leads to reduced recurrence rates and similar improvement of clinical symptoms compared with subtotal parathyroidectomy...
- Dihydropyridine- and voltage-sensitive Ca2+ entry in human parathyroid cellsKeitaro Yokoyama
Department of Nephrology and Hypertension, The Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
Exp Physiol 94:847-55. 2009..This Ca(2+) entry system might provide a compensatory pathway for the negative feedback regulation of parathyroid hormone secretion, especially in hyperplastic conditions in which the Ca(2+)-sensing receptor is poorly expressed...
- Biophysical properties of voltage-gated Na+ channels in frog parathyroid cells and their modulation by cannabinoidsYukio Okada
Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki 852 8588, Japan
J Exp Biol 208:4747-56. 2005..The results suggest that the Na+ currents in frog parathyroid cells can be modulated by cannabinoids via a G protein-dependent mechanism...
- Proliferation in hyperplastic human and normal rat parathyroid glands: role of phosphate, calcitriol, and genderYolanda Almaden
Unit of Investigation, Hospital Universitario Reina Sofia, Cordoba, Spain
Kidney Int 64:2311-7. 2003....
- A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidismC Ho
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 11:389-94. 1995..Our findings suggest that Casr mutations cause these human disorders by reducing the number of functional receptor molecules on the cell surface...
- Enlarged parathyroid glands discovered in normocalcemic patients during thyroid surgeryBassam Abboud
Department of General Surgery, Hotel Dieu de France Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Am J Surg 195:30-3. 2008This is a retrospective study analyzing data of normocalcemic patients with enlarged parathyroid glands discovered during thyroid surgery and comparing it with data of patients operated on for proved primary hyperparathyroidism.
- Radionuclide imaging of the parathyroid glands: patterns, pearls, and pitfallsJoel R Smith
Department of Radiology, New England Medical Center and Tufts University School of Medicine, NEMC 299, 750 Washington St, Boston, MA 02111, USA
Radiographics 24:1101-15. 2004..scintigraphy requires an understanding of (a) the embryologic, anatomic, and physiologic features of the parathyroid glands and (b) the properties of the two common imaging agents, technetium-99m sestamibi and Tc-99m tetrofosmin...
- Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordiaZhijie Liu
Department of Genetics, University of Georgia, Athens, GA 30602, USA
Dev Biol 305:333-46. 2007The parathyroid glands develop with the thymus from bilateral common primordia that develop from the 3rd pharyngeal pouch endoderm in mouse embryos at about E11, each of which separates into one parathyroid gland and one thymus lobe by ..
- Results of cryopreserved parathyroid autografts: a retrospective multicenter studySophie Borot
Endocrinology Department, University Hospital, Besancon, France
Surgery 147:529-35. 2010..Moreover, French tissue banks are facing an accumulation of ungrafted samples. The aim of our work was to evaluate the implantation rate of cryopreserved parathyroid samples and the functionality of CPAT in a multicenter study...
- Parathyroid hormone is essential for normal fetal bone formationDengshun Miao
Calcium Research Laboratory, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
J Clin Invest 109:1173-82. 2002..The effect of PTH on fetal osteoblasts may be relevant to its postnatal anabolic effects on trabecular bone...
- Robot assisted transaxillary surgery (RATS) for the removal of thyroid and parathyroid glandsChristine S Landry
Department of Surgical Oncology, Section of Surgical Endocrinology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Surgery 149:549-55. 2011..assisted transaxillary surgery (RATS) is a minimally invasive approach for the removal of the thyroid and/or parathyroid glands through the axilla...
- GCMB--another serendipitous gift from evolution to clinical investigatorsHenry M Kronenberg
J Clin Endocrinol Metab 89:6-7. 2004
- Influence of the parathyroid glands on bone metabolismH H Malluche
University of Kentucky, Lexington, KY 40536, USA
Eur J Clin Invest 36:23-33. 2006....
- Does vitamin D receptor and calcium receptor activation therapy play a role in the histopathologic alterations of parathyroid glands in refractory uremic hyperparathyroidism?Carlo Lomonte
Division of Nephrology, Miulli General Hospital, Acquaviva delle Fonti, Manduria, Italy
Clin J Am Soc Nephrol 3:794-9. 2008..This study was aimed to assess a possible association between histopathologic changes of parathyroid tissue and treatment modality...
- Activation of calcium-sensing receptor accelerates apoptosis in hyperplastic parathyroid cellsMasahide Mizobuchi
Department of Nephrology, School of Medicine, Showa University, Tokyo, Japan
Biochem Biophys Res Commun 362:11-6. 2007..Hyperplastic parathyroid glands were obtained from uremic rats (subtotal nephrectomy and high-phosphorus diet), and incubated in the media ..
- Total parathyroidectomy with autotransplantation in patients with renal hyperparathyroidism: indications and surgical approachStavros Gourgiotis
First Surgical Department Organ Transplant Unit, Evangelismos General Hospital, Athens, Greece
Hormones (Athens) 5:270-5. 2006..the purpose of this retrospective study was the evaluation of the surgical indications, parathyroid histology, and the results of total parathyroidectomy with autotransplantation (Ptx+At) in patients with rH...
- Can calcimimetics inhibit parathyroid hyperplasia? Evidence from preclinical studiesTilman Drueke
Nephrol Dial Transplant 22:1828-39. 2007
- Calcium paradox of aldosteronism and the role of the parathyroid glandsAlex Vidal
Division of Cardiovascular Diseases, Univ of Tennessee Health Science Center, 920 Madison Ave, Memphis, TN 38163, USA
Am J Physiol Heart Circ Physiol 290:H286-94. 2006..SHPT plays a permissive role in the proinflammatory vascular phenotype...
- Recent advances in physiological calcium homeostasisIndra Ramasamy
Department of Chemical Pathology, Newham University Hospital, London, UK
Clin Chem Lab Med 44:237-73. 2006..The former are mainly the kidneys, skeleton, intestine and the parathyroid glands. The latter comprise, amongst others, the parathyroid hormone, vitamin D and calcitonin...
- Incidence and location of ectopic abnormal parathyroid glandsRoy Phitayakorn
Department of Surgery, MetroHealth Medical Center, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
Am J Surg 191:418-23. 2006Ectopic parathyroid glands are a cause for failed parathyroid exploration.
- Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiencyMasahide Mizobuchi
Center for Blood Purification Therapy, Wakayama Medical University, Japan
J Am Soc Nephrol 15:2579-87. 2004....
- Rapid intraoperative localization of parathyroid glands utilizing methylene blue infusionDaniel B Kuriloff
Department of Otolaryngology Head and Neck Surgery, St Luke s Roosevelt Hospital Center and Columbia Univeristy College of Physicians and Surgeons, New York, NY 10019 1104, USA
Otolaryngol Head Neck Surg 131:616-22. 2004To review a single surgeon's experience utilizing an intraoperative methylene blue infusion (IMBI) to identify parathyroid glands during neck exploration for primary hyperparathyroidism.
- Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidismMatthew Colloton
Department of Metabolic Disorders, Amgen, Inc, Thousand Oaks, California 91320, USA
Kidney Int 67:467-76. 2005..The present study explores the effects of the calcimimetic cinacalcet HCl on parathyroid hyperplasia, apoptosis, and PTH secretion in a rat model of secondary HPT...
- Parathyroid growth and regression in experimental uremiaM Taniguchi
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, and Kidney Care Unit, Kyushu University, Fukuoka, Japan
Kidney Int 69:464-70. 2006..In addition, VD(3) treatment could reverse PT hyperplasia and hypertrophy via restoration of these proteins...
- Surgical indications and procedures of parathyroidectomy in patients with chronic kidney diseaseYoshihiro Tominaga
Department of Surgery, Renal Center, Nagoya Second Red Cross Hospital, 2 9 Myoken cho Showa ku Nagoya, Japan 4668650
Ther Apher Dial 9:44-7. 2005..The risk of recurrence is not negligible. Based on our huge experience we believe our strategy for advanced secondary hyperparathyroidism can be accepted at least in Japan...
- Parathyroid glands in calcium regulation and human diseaseGoran Akerstrom
Department of Surgical Sciences, University Hospital, Uppsala, Sweden
Ann N Y Acad Sci 1040:53-8. 2005..Newly developed vitamin D analogues with reduced calcemic effects and with more pronounced antiproliferative effect may provide new favorable treatment for reversal of HPT...
- Structure of non-(1-84) PTH fragments secreted by parathyroid glands in primary and secondary hyperparathyroidismPierre D'Amour
Centre de Recherche, Centre hospitalier de l Université de Montréal CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
Kidney Int 68:998-1007. 2005..We wanted to determine the N structure of non-(1-84) PTH fragments...
- Direct in vitro evidence of the suppressive effect of cinacalcet HCl on parathyroid hormone secretion in human parathyroid cells with pathologically reduced calcium-sensing receptor levelsTakehisa Kawata
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
J Bone Miner Metab 24:300-6. 2006..Data from this in vitro analysis support the clinical application of cinacalcet in PHPT and SHPT therapy...
- The impact of surgical technique on postoperative hypoparathyroidism in bilateral thyroid surgery: a multivariate analysis of 5846 consecutive patientsOliver Thomusch
Department of General Surgery, Albert Ludwigs University Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
Surgery 133:180-5. 2003..Limited information exists about risk factors for postoperative hypoparathyroidism after bilateral thyroid surgery...
- Relation between technetium 99m-methoxyisobutylisonitrile accumulation and multidrug resistance protein in the parathyroid glandsSatoshi Yamaguchi
Department of Urology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
World J Surg 26:29-34. 2002..MIBI) scintigraphy has been reported to be a useful method for visualizing the parathyroid glands for the diagnosis of hyperparathyroidism...
- Parathyroid function as a determinant of the response to calcitriol treatment in the hemodialysis patientM Rodriguez
Nephrology Services from the Hospital Universitario Reina Sofia, Cordoba, Spain
Kidney Int 56:306-17. 1999..Bolus calcitriol (CTR) is used for the treatment of secondary hyperparathyroidism in dialysis patients. Although CTR treatment reduces parathyroid hormone (PTH) levels in many dialysis patients, a significant number fail to respond...
- Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glandsN R Manley
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112 5331
Dev Biol 195:1-15. 1998The thymus, thyroid, and parathyroid glands in vertebrates develop from the pharyngeal region, with contributions both from pharyngeal endoderm and from neural crest cells in the pharyngeal arches...
- Calcimimetics with potent and selective activity on the parathyroid calcium receptorE F Nemeth
NPS Pharmaceuticals, Inc, 420 Chipeta Way, Salt Lake City, UT 84108, USA
Proc Natl Acad Sci U S A 95:4040-5. 1998..Calcimimetic compounds could conceivably provide a specific medical therapy for primary hyperparathyroidism...
- Cell biology of parathyroid hyperplasia in uremiaM Fukagawa
Division of Nephrology, Tokyo Teishin Hospital and University of Tokyo School of Medicine, Japan
Am J Med Sci 317:377-82. 1999..Genetic mutations and rearrangements of these cells in nodular hyperplasia remain to be fully elucidated in the near future to establish an effective method for the prevention of parathyroid hyperplasia in uremia...
- Genetic ablation of parathyroid glands reveals another source of parathyroid hormoneT Gunther
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 406:199-203. 2000The parathyroid glands are the only known source of circulating parathyroid hormone (PTH), which initiates an endocrine cascade that regulates serum calcium concentration...
- Cases with fewer than four parathyroid glands in patients with renal hyperparathyroidism at initial parathyroidectomyYatsuka Hibi
Department of Surgery II, School of Medicine, Nagoya University Hospital, 65 Tsurumai cho Showa ku, Nagoya 466, Japan
World J Surg 26:314-7. 2002..treatment of secondary hyperparathyroidism (2HPT) due to uremia, it is considered necessary to remove all parathyroid glands from the neck to prevent persistent and recurrent parathyroid hyperfunction...
- Fetal parathyroids are not required to maintain placental calcium transportC S Kovacs
Faculty of Medicine Endocrinology, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, Newfoundland A1B 3V6, Canada
J Clin Invest 107:1007-15. 2001..Hoxa3-null fetuses lack parathyroid glands, and absence of parathyroid hormone (PTH) was confirmed with a rodent PTH immunoradiometric assay...
- Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphateA J Brown
Renal Division, Washington University Medical School, St Louis, Missouri, USA
Kidney Int 55:1284-92. 1999..The cause of this down-regulation is unknown. Here we examined the roles of uremia and parathyroid hyperplasia on parathyroid gland (PTG) CaR expression in the rat model of renal failure...
- Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin DLucie Canaff
Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
J Biol Chem 277:30337-50. 2002..In summary, functional VDREs have been identified in the CASR gene and provide the mechanism whereby 1,25(OH)2D up-regulates parathyroid, thyroid C-cell, and kidney CASR expression...
- More than 1,000 cases of total parathyroidectomy with forearm autograft for renal hyperparathyroidismY Tominaga
Department of Surgery, Renal Center, Nagoya 2nd Red Cross Hospital, Nagoya
Am J Kidney Dis 38:S168-71. 2001..Based on histopathologic and pathophysiologic investigations, surgical treatment should be considered when parathyroid glands show nodular hyperplasia...
- Supernumerary parathyroid glands: frequency and surgical significance in treatment of renal hyperparathyroidismF N Pattou
Department of General and Endocrine Surgery, University Hospital, 59037 Lille, France
World J Surg 24:1330-4. 2000Supernumerary parathyroid glands (SPGs) are found in 13% of random autopsies. The high incidence of SPGs could explain the persistence or trigger recurrence of renal hyperparathyroidism after surgery...
- Weight of normal parathyroid glands in patients with parathyroid adenomasKathy Yao
Department of Breast and Endocrine Disease, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
J Clin Endocrinol Metab 89:3208-13. 2004..The weight of normal parathyroid glands removed at surgery in patients with PHP may be greater than that reported in autopsy studies...
- Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and BoneYu Xiao Yang; Fiscal Year: 2013..PPI-induced hypergastrinemia has a direct trophic effect on the parathyroid glands, leading to parathyroid hyperplasia, increased parathyroid hormone secretion and bone loss...
- Actions of Parathyroid Hormone (PTH)/PTH Related-Peptide Receptor in Osteocytes PAOLA DIVIETI PAJEVIC; Fiscal Year: 2013..Parathyroid hormone (PTH), an 84-amino-acid polypeptide secreted by the parathyroid glands, is a major physiologic regulator of calcium, phosphorous and skeletal homeostasis and, clinically, is the ..
- Innovative mouse model to study parathyroids and an application to human diseaseBeate Lanske; Fiscal Year: 2010..This mouse can then be induced to express different genes including siRNAs exclusively in the parathyroid glands through simple intraperitoneal injection of retroviral constructs...
- Dominant-negative GCMB mutations cause hypoparathyroidismMICHAEL MANNSTADT; Fiscal Year: 2012..Mice with homozygous ablation of Gcm2, one of the two mammalian orthologs, lack parathyroid glands and develop hypocalcemia and hyperphosphatemia...
- Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin DBeate Lanske; Fiscal Year: 2012..mice despite similar serum biochemistry suggesting that Fgf23 has different effects than Klotho on parathyroid glands. Furthermore, we will examine the outcome of intermittent vs...
- The Role of GCM2 in Parathyroid Gland HomeostasisMICHAEL ALAN LEVINE; Fiscal Year: 2013..cell-specific transcription factor Gcm2 (glial cell missing 2) after early embryologica development of the parathyroid glands as well how this protein functions in mature parathyroid glands to control function and survival of ..
- BONE PROPERTIES IN HYPOPARATHYROIDISM: EFFECTS OF PTHJohn P Bilezikian; Fiscal Year: 2013..It is due primarily to surgical removal of all parathyroid tissue or autoimmune destruction of the parathyroid glands. The absence of PTH leads to a reduction in the serum calcium concentration that can be asymptomatic or ..
- The Regulation of the Parathyroid GlandBeate Lanske; Fiscal Year: 2013..Our second aim is to pursue data we generated from the first ever microarray analysis of mouse parathyroid glands. Our analysis has discovered the expression of some genes in hyperplasic glands that have not been reported ..
- Breakthrough intra-operative detection of the parathyroid glandsAnita Mahadevan-Jansen; Fiscal Year: 2012..This happens because Parathyroid glands are difficult to distinguish from the thyroid and surrounding tissues in the neck...
- Modeling of Hyperparathyroidism-Jaw Tumor Syndrome by Targeted Deletion of Hrpt2Jessica Costa; Fiscal Year: 2012..are designed to address the mechanisms through which loss of Hrpt2/parafibromin promotes neoplasia in the parathyroid glands and jaws, in the pathophysiologically relevant experimental context of an intact animal...
- Molecular mechanisms and epigenetic signatures that specify thymus fateEllen R Richie; Fiscal Year: 2013..5 and E11 during mouse fetal development;the dorsal domain of this pouch gives rise to the parathyroid glands. As the 3rd pp must be patterned into two distinct cell fates, mechanisms must be in place to ensure that ..
- GENETIC LINKAGE MAPPING OF FAMILIAL BENIGN HYPERCALCEMIAHunter Heath; Fiscal Year: 1991..normal to slightly elevated plasma parathyroid hormone (PTH) levels, and usually unremarkable parathyroid glands. Subtotal parathyroidectomy does not mitigate the biochemical abnormalities...
- DESENSITIZATION AND DOWN REGULATION OF CALCIUM RECEPTORSDolores Shoback; Fiscal Year: 2002..CaR protein expression is reduced in parathyroid glands from patients with primary hyperparathyroidism...
- PARATHYROID IMAGING BY RADIOLABELED MONOCLONAL ANTIBODYWILLIAM TOLBERT; Fiscal Year: 1990..of this technology would provide surgeons with preoperative knowledge of the precise location(s) of the parathyroid glands, resulting in shorter and more direct surgical procedures which will provide patients with reduced morbidity...
- Calcium Sensing Receptor in Human Airway EpitheliumPHILLIP LAMBERTY; Fiscal Year: 2003..an interesting protein initially characterized in the elucidation of parathyroid hormone release by bovine parathyroid glands. A G-protein coupled receptor, described agonists other than calcium include other polycations (Mg2+, Gd3+), ..
- Genetics of Maxillary/Mandibular DiscrepanciesLinda Krebs; Fiscal Year: 2005..Most cases of primary HPT are due to a solitary benign adenoma in one of the parathyroid glands. Molecular allelotyping and CGH have been used to identify areas in the genome where tumor suppressor genes ..
- CALCIUM RECEPTOR IN MAMMARY DEVELOPMENT AND PHYSIOLOGYJoshua VanHouten; Fiscal Year: 2006..MG) of wild type mice, CaR mice, and CaR-/- mice made viable by the genetically engineered absence of parathyroid glands (CaR-/-/Gcm2-/-)...
- Cyclin D1 in oral carcinogenesisSANJAY MALLYA; Fiscal Year: 2006..In our mouse model of primary HPT, cyclin D1 deregulation causes hypercellularity and enlargement of the parathyroid glands. However, it has not been established whether these glandular enlargements represent polyclonal ..
- Carboxyl-Terminal PTH Receptors in Bone CellF Bringhurst; Fiscal Year: 2006..PTH C-fragments are secreted in a calcium-regulated manner by the parathyroid glands and generated also by peripheral cleavage of intact PTH...
- Signaling Complexes in Renal Epithelial CellsRichard Miller; Fiscal Year: 2005..is a G protein-coupled receptor that responds to Ca and other polycations to regulate PTH secretion by the parathyroid glands and Ca, NaCI, KCl, and H20 transport in the kidney...
- CHARACTERIZATION OF FETOPLACENTAL PTH-LIKE FACTORSLewis Rubin; Fiscal Year: 1990..that circulating PTH-like bioactivity in fetal lambs is partially independent of the presence of the parathyroid glands. Furthermore, it appears that sheep placenta contains PTH-like bioactive factors that may resemble the PTH-..
- TWO X-LINKED GENES THAT REGULATE MINERAL HOMEOSTASISMichael Whyte; Fiscal Year: 2002..disorders mapped to the two loci of interest show that one gene is essential for embryogenesis of the parathyroid glands (and thereby maintenance of extracellular fluid calcium levels), and the other gene controls blood phosphate ..
- Molecular Pathogenesis of Hyperparathysoidism in Chronic Kidney DiseasesKelly Lauter; Fiscal Year: 2010..Through studying their pathologic parathyroid glands, we will aim to uncover mechanisms of this benign aberrant cell growth...
- GENETIC BASIS OF HYPERPARATHYRODISM-JAW TUMOR SYNDROMEMaurine Hobbs; Fiscal Year: 2001..occur in this region of about 250kb, and these will be prioritized for mutation screening by expression in parathyroid glands using an existing parathyroid adenoma library or RT-PCR from parathyroid mRNA...
- PTH-RELATED PROTEIN IN THE PANCREATIC ISLETAndrew Stewart; Fiscal Year: 2002..should broaden the understanding of the mechanisms of action of PTHrP in the large range of normal tissues (parathyroid glands, the epidermis, the mammary gland, and the skeleton) which produce this ubiquitous paracrine/autocrine/..
- Coronary calcification in hemodialysis patientsWilliam Goodman; Fiscal Year: 2005....
- DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILUREWilliam Goodman; Fiscal Year: 2001....
- Actions of Parathyroid Hormone(PTH)/PTH related-peptide receptor in Osteocytes inPaola Divieti; Fiscal Year: 2008..Parathyroid hormone (PTH), an 84-amino-acid polypeptide secreted by the parathyroid glands, is a major physiologic regulator of calcium, phosphorous and skeletal homeostasis and, clinically, is the ..
- Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine TumorsHerbert Chen; Fiscal Year: 2008..Besides surgery, there are limited curative and palliative treatments available to patients with metastatic NE tumors, emphasizing the need for development of other forms of therapy. [unreadable] [unreadable] [unreadable]..
- Regulating Neuroendocrine Phenotype in CancerHerbert Chen; Fiscal Year: 2010..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
- GAMMA INTERFERON REGULATION OF VITAMIN D ACTIONAdriana Dusso; Fiscal Year: 2002..abstract_text> ..
- AMINO AND CARBOXYL TERMINAL PTH RECEPTORS IN OSTEOCYTESPaola Divieti; Fiscal Year: 2004..These results could have significant implications for therapy of bone disorders such as hyperparathyroidism, osteoporosis and renal osteodystrophy. ..
- Vitamin D Control of TGFa/EFG Receptor Growth SignalingAdriana Dusso; Fiscal Year: 2006..By identifying pathogenic mechanisms, these studies should help design more effective therapies for secondary hyperparathyroidism. [unreadable] [unreadable]..
- Novel Signaling Targets in GI Neuroendocrine TumorsHerbert Chen; Fiscal Year: 2005..The possibility that raf-l-mediated hormone suppression could be induced by a soluble factor would provide a plausible, therapeutic delivery method. ..
- AMINO AND CARBOXYL TERMINAL PTH RECEPTORS IN OSTEOCYTESPaola Divieti; Fiscal Year: 2004..These studies will provide new insight into osteocytes and osteoclasts function and of the role of intact, N-terminal and C-terminal PTH in regulating their behavior. ..
- Signaling Pathways in Medullary Thyroid CancerHerbert Chen; Fiscal Year: 2004..abstract_text> ..
- Targeting Bone Remodeling For the Treatment of OsteoporosisJohn Bilezikian; Fiscal Year: 2008..The purpose of this meeting is to bring together experts from these interdisciplinary fields so as to define the direction of the future. ..
- CA2+ SENSING RECEPTOR EXPRESSION IN HYPERPARATHYROIDISMAlex Brown; Fiscal Year: 2002b>Parathyroid glands (PTGs) express a calcium-sensing receptor (CaR) that detects the concentration of extracellular calcium and signals the glands to secrete the proper amount of parathyroid hormone (PTH) to maintain normal calcium levels...
- PHARMACOLOGY OF BOVINE PARATHYROID CA++ RECEPTORSEdward M Brown; Fiscal Year: 2002....
- Phase I Serum-free cultured thymus transplantation in DiGeorge anomaly, IND9836, MARY MARKERT; Fiscal Year: 2009..The focus of these experiments is the development of thymopoiesis and normal presentation of promiscuously expressed antigens in the thymus. ..
- Dose Study of thymus TransplantationMARY MARKERT; Fiscal Year: 2007..Abstract Not Provided. ..
- CALCIUM RECEPTOR SIGNAL RECOGNITION AND TRANSDUCTIONEdward M Brown; Fiscal Year: 2006..abstract_text> ..
- CA2+ RECEPTOR, PTHRP & MALIGNANCY-INDUCED OSTEOLYSISEdward M Brown; Fiscal Year: 2004..abstract_text> ..
- PET Imaging of the Pancreas in Murine Models of DiabetesPaige Clark; Fiscal Year: 2005..The method could also be useful in evaluating the function of pancreatic transplants and successful engraftment of transplanted progenitor or beta cells. ..
- INHIBITION OF PTH SECRETION: CaR AND THE CYTOSKELETONEdward M Brown; Fiscal Year: 2007..Phosphorylation of caveolin-1 under high Ca 2+ conditions may anchor the CaR-PTH unit to the plasma membrane, limiting PTH secretion. ..
- Dynamics of TCR Repertoire Following Thymus TransplantMARY MARKERT; Fiscal Year: 2008..Infants with DiGeorge syndrome are born with defects in the thymus, heart, and parathyroid glands. Patients with "complete" DiGeorge syndrome have no evidence ofthymic function...
- Parathyroid and Thymus Transplants in DiGeorge SyndromeMARY MARKERT; Fiscal Year: 2005..Indirect allorecognition as a mechanism of graft rejection will be assessed by ELISpot. The third aim will assess safety and tolerability. ..
- CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITROEdward M Brown; Fiscal Year: 2007..3) To develop an animal model of activating and/or inactivating antibodies by immunization with the CaR's extracellular domain. [unreadable] [unreadable]..
- PRIMARY HYPERPARATHYROIDISM: NON-CLASSICAL MANIFESTATIONSShonni Silverberg; Fiscal Year: 2009..abstract_text> ..
- GENETICS OF FAMILIAL FOCAL SEGMENTAL GLOMERULOSCLEROSISL Quarles; Fiscal Year: 2002..Knowledge derived from FFSGS will also allow a better understanding of pathogenesis of non-hereditary forms FSGS and may provide insights regarding management of the more common sporadic forms of this disorder. ..
- Improving genomic prediction models in breast cancerJohn Olson; Fiscal Year: 2005....
- Mechanisms of cervical thymus developmentNancy Manley; Fiscal Year: 2008..If it is the latter, this raises the intriguing possibility that latent thymic potential may exist in everyone, and thus may represent a novel therapeutic target for thymic regeneration and rebound. [unreadable] [unreadable] [unreadable]..
- Physiological Model of Parathyroid Hormone SecretionDanny Petrasek; Fiscal Year: 2006..In a broader view, our preliminary results suggest that in addition to the cellular mechanisms, glandular networks may have regulatory prowess at the level of interstitial transport. ..
- Regulation of thymic epithelial cell differentiationNancy Manley; Fiscal Year: 2007..Further, our identification of a new function for the N-terminal domain may have implications for functional domains in other forkhead family transcription factors. ..
- EXTRACELLULAR CALCIUM-SENSING RECEPTORS IN OSTEOBLASTSL Quarles; Fiscal Year: 2009..Successful completion of this project is certain to yield important new knowledge regarding the function of GPRC6A. ..
- RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASESChou Long Huang; Fiscal Year: 2005..The biochemical studies will be correlated with electrophysiological recording of channel activity. ..
- Genetic analysis of thymus organogenesisNancy Manley; Fiscal Year: 2007..goal of this research is to understand the molecular mechanisms controlling organogenesis of the thymus and parathyroid glands in mice...