parathyroid glands

Summary

Summary: Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.

Top Publications

  1. ncbi Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid
    E M Brown
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Nature 366:575-80. 1993
  2. ncbi Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients
    Hirotaka Komaba
    Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
    Kidney Int 77:232-8. 2010
  3. ncbi Subtotal parathyroidectomy as an adequate treatment for primary hyperparathyroidism in multiple endocrine neoplasia type 1
    Johnathan G H Hubbard
    Department of Endocrine Surgery, University Hospital La Timone, Marseille, France
    Arch Surg 141:235-9. 2006
  4. ncbi Ultrasound of the thyroid and parathyroid glands
    Nadia Khati
    Department of Radiology, The George Washington University, Washington, DC 20037, USA
    Ultrasound Q 19:162-76. 2003
  5. ncbi FGF23 and the parathyroid glands
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem, 91120, Israel
    Pediatr Nephrol 25:2241-5. 2010
  6. pmc FGF23 fails to inhibit uremic parathyroid glands
    Rocio Canalejo
    Unidad de Investigacion, Servicio de Nefrologia, Departamento de Medicina, Red in ren, Instituto Maimó nides de Invstigación Biomédica de Córdoba, Hospital Universitario Reina Sofia, Cordoba, Spain
    J Am Soc Nephrol 21:1125-35. 2010
  7. ncbi Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options
    John Cunningham
    Centre for Nephrology, UCL Medical School, Royal Free Campus, London, United Kingdom
    Clin J Am Soc Nephrol 6:913-21. 2011
  8. ncbi Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl
    Edward F Nemeth
    Amgen, Inc, Thousand Oaks, CA 91320 1799, USA
    J Pharmacol Exp Ther 308:627-35. 2004
  9. pmc Cinacalcet effectively reduces parathyroid hormone secretion and gland volume regardless of pretreatment gland size in patients with secondary hyperparathyroidism
    Hirotaka Komaba
    Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
    Clin J Am Soc Nephrol 5:2305-14. 2010
  10. ncbi Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology
    Tomer Meir
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hospital, Jerusalem, Israel
    Am J Physiol Renal Physiol 297:F1192-8. 2009

Detail Information

Publications260 found, 100 shown here

  1. ncbi Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid
    E M Brown
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Nature 366:575-80. 1993
    ....
  2. ncbi Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients
    Hirotaka Komaba
    Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
    Kidney Int 77:232-8. 2010
    ..b>Parathyroid glands express both FGFR1 and Klotho, and FGF23 decreases parathyroid hormone gene expression and hormone secretion ..
  3. ncbi Subtotal parathyroidectomy as an adequate treatment for primary hyperparathyroidism in multiple endocrine neoplasia type 1
    Johnathan G H Hubbard
    Department of Endocrine Surgery, University Hospital La Timone, Marseille, France
    Arch Surg 141:235-9. 2006
    ..In view of our large experience in patients with secondary HPT for whom TP with autotransplantation did not simplify reoperations, SP remains our preferred treatment for patients with HPT and multiple endocrine neoplasia type 1...
  4. ncbi Ultrasound of the thyroid and parathyroid glands
    Nadia Khati
    Department of Radiology, The George Washington University, Washington, DC 20037, USA
    Ultrasound Q 19:162-76. 2003
    ..In patients in whom the studies do not agree or in whom they do not detect the adenoma, further evaluation with CT or more preferably MRI is indicated...
  5. ncbi FGF23 and the parathyroid glands
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem, 91120, Israel
    Pediatr Nephrol 25:2241-5. 2010
    ..Klotho-FGFR1c is also expressed in the parathyroid glands. FGF23 acts on the receptor complex in the parathyroid glands to decrease parathyroid hormone (PTH) gene ..
  6. pmc FGF23 fails to inhibit uremic parathyroid glands
    Rocio Canalejo
    Unidad de Investigacion, Servicio de Nefrologia, Departamento de Medicina, Red in ren, Instituto Maimó nides de Invstigación Biomédica de Córdoba, Hospital Universitario Reina Sofia, Cordoba, Spain
    J Am Soc Nephrol 21:1125-35. 2010
    ..Here, we investigated the effect of FGF23 on parathyroid function in normal and uremic hyperplastic parathyroid glands in rats...
  7. ncbi Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options
    John Cunningham
    Centre for Nephrology, UCL Medical School, Royal Free Campus, London, United Kingdom
    Clin J Am Soc Nephrol 6:913-21. 2011
    ..Future strategies may focus on the stimulation of apoptotic activity of hyperplastic parathyroid cells...
  8. ncbi Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl
    Edward F Nemeth
    Amgen, Inc, Thousand Oaks, CA 91320 1799, USA
    J Pharmacol Exp Ther 308:627-35. 2004
    ..The present findings provide compelling evidence that cinacalcet HCl is a potent and stereoselective activator of the parathyroid CaR and, as such, might be beneficial in the treatment of hyperparathyroidism...
  9. pmc Cinacalcet effectively reduces parathyroid hormone secretion and gland volume regardless of pretreatment gland size in patients with secondary hyperparathyroidism
    Hirotaka Komaba
    Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
    Clin J Am Soc Nephrol 5:2305-14. 2010
    ..However, it has not been proven whether parathyroid gland size predicts response to therapy and whether cinacalcet is capable of inducing a reduction in parathyroid volume...
  10. ncbi Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology
    Tomer Meir
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hospital, Jerusalem, Israel
    Am J Physiol Renal Physiol 297:F1192-8. 2009
    ..The sensitivity of the parathyroid glands of the PT-VDR(-/-) mice to calcium was intact as measured by serum PTH levels after changes in serum calcium...
  11. ncbi The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats
    Mario Cozzolino
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Am Soc Nephrol 13:2299-308. 2002
    ..These findings cannot be extrapolated to human disease, and further studies in patients are necessary to determine the benefits of either P binder...
  12. pmc Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidism
    Mario Meola
    Department of Internal Medicine, S Anna School of Advanced Studies, Nephrology and Dialysis Unit, University of Pisa, Italy
    Nephrol Dial Transplant 24:982-9. 2009
    The effect of cinacalcet on the structural pattern of hyperplastic parathyroid glands was evaluated, using high-resolution colour Doppler (CD) sonography, in haemodialysis patients with severe, inadequately controlled, secondary ..
  13. ncbi Primary hyperparathyroidism: a current perspective
    Ronald A DeLellis
    Department of Pathology, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Arch Pathol Lab Med 132:1251-62. 2008
    ..Additionally, imaging studies and the development of the intraoperative assay for parathyroid hormone have transformed the diagnosis and management of patients with these disorders...
  14. ncbi Pathogenesis of parathyroid hyperplasia in renal failure
    Mario Cozzolino
    Renal Division, San Paolo Hospital, Milan Italy
    J Nephrol 18:5-8. 2005
    ..In this review, we analyze the current understanding concerning the new insights into the molecular mechanisms of parathyroid hyperplasia and PTH secretion in renal failure regulated by calcium, phosphate and vitamin D...
  15. ncbi alpha-Klotho as a regulator of calcium homeostasis
    Akihiro Imura
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Science 316:1615-8. 2007
    ..Our findings reveal fundamental roles of alpha-Kl in the regulation of calcium metabolism...
  16. ncbi Ultrasonography in detection of single and multiple abnormal parathyroid glands in primary hyperparathyroidism: comparison with radionuclide scintigraphy and surgery
    A Bhansali
    Endocrinology and Metabolism, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Clin Endocrinol (Oxf) 65:340-5. 2006
    ..Among the parathyroid imaging techniques, ultrasonography (USG) has the advantage of convenience, easy availability and low cost...
  17. ncbi FGF23-parathyroid interaction: implications in chronic kidney disease
    Hirotaka Komaba
    Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
    Kidney Int 77:292-8. 2010
    ..resistance to FGF23 may be caused by decreased expression of Klotho-FGFR1 complex in hyperplastic parathyroid glands. This review summarizes recent insights into the role of FGF23 in mineral homeostasis and discusses the ..
  18. ncbi 25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 87:2967-72. 2002
    ..The findings imply that in addition to feedback control by circulating 1,25(OH)(2)D(3) levels, parathyroid cells may also be influenced by local 1alpha -hydroxylase activity with possible growth regulatory and differentiating effects...
  19. ncbi Radionuclide imaging of the parathyroid glands
    Christopher J Palestro
    Department of Nuclear Medicine and Radiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Semin Nucl Med 35:266-76. 2005
    The parathyroid glands, which usually are situated behind the thyroid gland, secrete parathyroid hormone, or PTH, which helps maintain calcium homeostasis. Primary hyperparathyroidism results from excess parathyroid hormone secretion...
  20. ncbi Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5
    O Chisaka
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Nature 350:473-9. 1991
    ..In addition, they often feature defects of the heart and arteries as well as craniofacial abnormalities. These deficiencies are remarkably similar to the pathology of the human congenital disorder DiGeorge's syndrome...
  21. ncbi Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndrome
    William F Simonds
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:96-102. 2004
    ..Even accounting for families with one of the three occult syndromes and false negative biochemical or DNA testing, these results indicate that an unexpectedly large fraction of FIHP has currently unrecognized causes...
  22. ncbi Virtual neck exploration: a new method for localizing abnormal parathyroid glands
    Rupert Prommegger
    Department of Operative Medicine, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Ann Surg 250:761-5. 2009
    ..The aim of this study was to evaluate whether CT-MIBI-SPECT image fusion is superior to MIBI-SPECT and CT in detecting abnormal parathyroid glands in patients with primary hyperparathyroidism.
  23. ncbi Hoxa3 and pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesis
    D Su
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Dev Biol 236:316-29. 2001
    The thymus and parathyroid glands in mice develop from a thymus/parathyroid primordium that forms from the endoderm of the third pharyngeal pouch...
  24. ncbi Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue
    Ming Lu
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Mol Cell Endocrinol 287:72-80. 2008
    ..1micromol/l). SNAP-25 (and Syntaxin1) appears to be a tumour-specific protein(s) in parathyroid tissues since its expression was restricted to pathological tissues...
  25. ncbi Influence of donor MHC class I antigen expression on graft survival after rat parathyroid allotransplantation
    S Timm
    Department of Surgery, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Langenbecks Arch Surg 386:430-3. 2001
    ..We investigated the influence of donor MHC antigen expression on graft survival after parathyroid transplantation in three different strain combinations...
  26. ncbi Expression of cellular retinol- and retinoic acid-binding proteins in normal and pathologic human parathyroid glands
    H Melhus
    Department of Medical Sciences, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Endocr Pathol 12:423-7. 2001
    ..In the present study, we identified Ito-like cells in parathyroid glands, suggesting local stores of vitamin A...
  27. ncbi Surgical anatomy of the thyroid and parathyroid glands
    Frank R Miller
    Department of Otolaryngology Head and Neck Surgery, University of Texas Health Science Center, 7703 Floyd Curl Drive, Code 7777, San Antonio, San Antonio, TX 78248, USA
    Otolaryngol Clin North Am 36:1-7, vii. 2003
    ..These critical structures include the recurrent laryngeal nerves, the superior laryngeal nerves, and the parathyroid glands. Successful thyroid surgery depends on the technical skill of the surgeon to identify and preserve these ..
  28. ncbi Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma
    Ming Lu
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital L1 03, SE 171 76 Stockholm, Sweden
    J Endocrinol 208:31-9. 2011
    ..Taken together, these results show that calmodulin negatively contributes to the regulation of PTH secretion in parathyroid adenoma, at least partially via a CaMKII pathway...
  29. ncbi Successful implant of long-term cryopreserved parathyroid glands after total parathyroidectomy
    Fábio Luiz de Menezes Montenegro
    Department of Head and Neck Surgery, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Head Neck 29:296-300. 2007
    ..Parathyroid cryopreservation is essential in some cases of parathyroid surgery. The fate of autografted tissue after long-term cryopreservation is not fully discussed in the literature...
  30. ncbi Xenotransplantation of parathyroids in rats using barium-alginate and polyacrylic acid multilayer microcapsules
    A Gaumann
    , , Germany
    Exp Toxicol Pathol 53:35-43. 2001
    ..In contrast minced tissue underwent necrosis and induced significantly more connective tissue reaction than single cells indicating an interrelationship between necrosis and fibrosis...
  31. ncbi Presurgical localization of abnormal parathyroid glands using a single injection of Tc-99m sestamibi: comparison of high-resolution parallel-hole and pinhole collimators, and interobserver and intraobserver variation
    Anne Kirstine Arveschoug
    Department of Clinical Physiology, Aalborg Hospital, DK 9100 Aalborg, Denmark
    Clin Nucl Med 27:249-54. 2002
    Scintigraphy using Tc-99m sestamibi is sensitive in localizing abnormal parathyroid glands in patients with hyperparathyroid disease (HPT)...
  32. ncbi Primary hyperparathyroidism in MEN 1--how radical should surgery be?
    Johnathan G H Hubbard
    Department of Endocrine Surgery, University Hospital La Timone, Boulevard Jean Moulin, 13385 Marseilles Cedex 5, France
    Langenbecks Arch Surg 386:553-7. 2002
    ..As radical as surgery is for hyperparathyroidism in MEN 1, the surgeon must take steps to avoid permanent hypoparathyroidism, which in young patients may be worse than the disease itself...
  33. ncbi Number of enlarged parathyroid glands might be a predictor of cinacalcet response in advanced secondary hyperparathyroidism
    Masahiro Yamamoto
    Department of Internal Medicine, Showa University Northern Yokohama Hospital, 35 1 Chigasaki chuo, Tsuzuki, Yokohama, Kanagawa, 2248503, Japan
    Clin Exp Nephrol 16:292-9. 2012
    ..We investigated clinical factors influencing therapeutic response to cinacalcet for SHPT refractory to active vitamin D sterols...
  34. ncbi Parathyroid hormone without parathyroid glands
    Robert Gensure
    Endocrinology 146:544-6. 2005
  35. ncbi The calcimimetic R-568 increases vitamin D receptor expression in rat parathyroid glands
    M E Rodriguez
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    Am J Physiol Renal Physiol 292:F1390-5. 2007
    ..In vitro studies of the effect of R-568 on VDR mRNA and protein were conducted in cultures of whole rat parathyroid glands and human hyperplastic parathyroid glands...
  36. ncbi The calcimimetic AMG 641 abrogates parathyroid hyperplasia, bone and vascular calcification abnormalities in uremic rats
    Charles Henley
    Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, CA 91320, USA
    Eur J Pharmacol 616:306-13. 2009
    ..These results suggest that calcimimetics can reduce the development of vascular calcification, parathyroid hyperplasia and bone abnormalities associated with secondary hyperparathyroidism...
  37. ncbi Treatment of osteoporosis with TheraCyte-encapsulated parathyroid cells: a study in a rat model
    F F Chou
    Department of General Surgery, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung University 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan, Republic of China
    Osteoporos Int 17:936-41. 2006
    ....
  38. ncbi Familial isolated hyperparathyroidism maps to the hyperparathyroidism-jaw tumor locus in 1q21-q32 in a subset of families
    B T Teh
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    J Clin Endocrinol Metab 83:2114-20. 1998
    ..Taken together, the results suggest that some of the FIHP are a variant of HPT-JT and that the gene involved is a tumor suppressor gene...
  39. ncbi Selected markers of proliferation and apoptosis in the parathyroid lesions: a spatial visualization and quantification
    Elzbieta Kaczmarek
    Department of Pathomorphology, University of Medical Sciences in Poznan, Przybyszewski Str 49, 60355, Poznan, Poland
    J Mol Histol 39:509-17. 2008
    ....
  40. ncbi Parathyroid hormone 7-84 induces hypocalcemia and inhibits the parathyroid hormone 1-84 secretory response to hypocalcemia in rats with intact parathyroid glands
    Jinxing Huan
    Nephrological Department P, Rigshospitalet, Herlev Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
    J Am Soc Nephrol 17:1923-30. 2006
    ..calcium-sensing receptor (CaR), PTH type 1 receptor (PTHR1), and PTH-related peptide (PTHrP) genes in rat parathyroid glands. PTH 7-84 induced a significant decrease in plasma Ca2+ in rats with intact parathyroid glands...
  41. ncbi [Functional results of parathyroid autotransplantation in one single pocket for treatment of secondary hyperparathyroidism]
    Caio Tosato Caliseo
    Laboratório de Investigação Médica 28, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR
    Rev Col Bras Cir 38:85-9. 2011
    ..To evaluate the operation and surgical time of autotransplanted parathyroid in a single site comparing it to the implant performed in five and twenty locations...
  42. ncbi Distribution and regulation of the 25-hydroxyvitamin D3 1α-hydroxylase in human parathyroid glands
    Cynthia S Ritter
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, United States
    J Steroid Biochem Mol Biol 130:73-80. 2012
    b>Parathyroid glands express the 25-hydroxyvitamin D(3) 1α-hydroxylase (1αOHase)...
  43. ncbi Characterization of heparanase from a rat parathyroid cell line
    Katarzyna A Podyma-Inoue
    Division of Biochemistry, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8459, Japan
    J Biol Chem 277:32459-65. 2002
    ..Further elucidation of the roles of heparanase in normal physiological processes would provide an important tool for analyzing the regulation of heparan sulfate-dependent cell functions...
  44. ncbi Ultrasonography for preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism: comparison with (99m)technetium sestamibi scintigraphy
    Richard S Haber
    Departments of Medicine, Mount Sinai School of Medicine, New York 10029, USA
    Clin Endocrinol (Oxf) 57:241-9. 2002
    To determine the utility of ultrasonography for the preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism, and to compare this method with (99m)technetium sestamibi scintigraphy.
  45. ncbi Short-term immunosuppression after rat parathyroid allotransplantation
    Stephan Timm
    Department of Surgery, University of Wurzburg, Wurzburg, Germany
    Microsurgery 23:503-7. 2003
    ..Whether the combination of an additional graft pretreatment and immunosuppression has an impact on graft function will be further examined...
  46. ncbi Incidental extirpation of the parathyroid glands at thyroid surgery: risk factors and post-operative hypocalcemia
    Ghazi Raji Qasaimeh
    Department of General Surgery Medical College, King Abdullah University Hospital, Jordan University of Science and Technology, PO Box 1592, Irbid, Jordan
    Eur Arch Otorhinolaryngol 268:1047-51. 2011
    The objective of this study was to estimate the incidence of incidental extirpation of the parathyroid glands during thyroid operations, and to investigate possible risk factors and post-thyroidectomy complications using a descriptive ..
  47. ncbi MR imaging of the thyroid and parathyroid glands
    M B Gotway
    Department of Radiology, and Cardiovascular Research, University of California, San Francisco School of Medicine, USA
    Magn Reson Imaging Clin N Am 8:163-82, ix. 2000
    ..MR imaging of the parathyroid glands is generally used for patients with recurrent or persistent hyperparathyroidism following neck exploration...
  48. ncbi Development of parathyroid gland hyperplasia without uremia: role of dietary calcium and phosphate
    Antonio Canalejo
    Department of Environmental Biology and Public Health, University of Huelva, Huelva, Spain
    Nephrol Dial Transplant 25:1087-97. 2010
    ..Methods. We evaluated the functional response of the parathyroid glands in normal rats to different physiological demands an HPD 0.6% Ca, 1.2% P) and LCD 0.2% Ca, 0...
  49. ncbi Microencapsulation of human parathyroid cells: an "in vitro" study
    L Picariello
    Surgery Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    J Surg Res 96:81-9. 2001
    ..CONCLUSIONS: These findings represent a crucial step toward the construction of functional bioartificial parathyroid organoids for the treatment of hypoparathyroidism in humans...
  50. ncbi Vitamin D-independent therapeutic effects of extracellular calcium in a mouse model of adult-onset secondary hyperparathyroidism
    Karin Weber
    Institute of Animal Physiology, Ludwig Maximilians University, Munich, Germany
    J Bone Miner Res 24:22-32. 2009
    ..from the RD to the CD for 2 mo, they developed severe sHPT associated with hypertrophy and hyperplasia of parathyroid glands and profound bone loss...
  51. ncbi Frequency of ectopic and supernumerary intrathymic parathyroid glands in patients with renal hyperparathyroidism: analysis of 461 patients undergoing initial parathyroidectomy with bilateral cervical thymectomy
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    World J Surg 35:1260-5. 2011
    The frequency of intrathymic parathyroid glands (IPGs) in patients undergoing parathyroidectomy for renal hyperparathyroidism (rHPT) varies considerably between 14.8% and 45.3%...
  52. ncbi Resection of ectopic mediastinal parathyroid glands with the da Vinci robotic system
    M Ismail
    Department of General, Visceral, Vascular and Thoracic Surgery, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Germany
    Br J Surg 97:337-43. 2010
    ..Thoracoscopic access is associated with reduced morbidity in mediastinal surgery. The aim of this study was to evaluate the feasibility and effectiveness of robot-assisted dissection for mediastinal ectopic parathyroid glands.
  53. ncbi p21(WAF1) and transforming growth factor-alpha mediate dietary phosphate regulation of parathyroid cell growth
    A S Dusso
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Kidney Int 59:855-65. 2001
    ..In addition to reducing p21, high P-induced PT growth could result from increased PT expression of the growth promoter transforming growth factor-alpha (TGF-alpha), known to be elevated in hyperplastic and adenomatous human PT glands...
  54. ncbi Effects of time on ultrastructural integrity of parathyroid tissue before cryopreservation
    Carlos Eduardo Santa Ritta Barreira
    Department of Head and Neck Surgery, University of Sao Paulo Medical School, Sao Paulo, Brazil
    World J Surg 35:2440-4. 2011
    ..The present study evaluates the time that the human hyperplastic parathyroid gland tissue can wait before cryopreservation, based on parathyroid cell ultrastructural integrity...
  55. ncbi Near-infrared autofluorescence for the detection of parathyroid glands
    Constantine Paras
    Vanderbilt University, Department of Biomedical Engineering, VU Station B Box 351631, Nashville, Tennessee 37235, USA
    J Biomed Opt 16:067012. 2011
    A major challenge in endocrine surgery is the intraoperative detection of parathyroid glands during both thyroidectomies and parathyroidectomies...
  56. ncbi Expression and association of TRPC subtypes with Orai1 and STIM1 in human parathyroid
    Ming Lu
    Departments of Molecular Medicine and Surgery Oncology Pathology, Karolinska Institutet, Karolinska University Hospital L1 03, 171 76 Stockholm, Sweden
    J Mol Endocrinol 44:285-94. 2010
    ..Furthermore, co-immunoprecipitation experiments demonstrated a ternary complex of TRPC1-Orai1-STIM1, supporting a physical interaction between these molecules in human parathyroid...
  57. ncbi High extracellular Ca2+ hyperpolarizes human parathyroid cells via Ca(2+)-activated K+ channels
    Stiina Välimäki
    Department of Molecular Medicine, Karolinska Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Biol Chem 278:49685-90. 2003
    ....
  58. ncbi A proteomic approach to study parathyroid glands
    Laura Giusti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, Via, Bonanno 6, 56126 Pisa, Italy
    Mol Biosyst 7:687-99. 2011
    ..The functional role of these proteins in the network of intracellular pathways is discussed...
  59. ncbi Natural history of parathyroid function and calcium metabolism after kidney transplantation: a single-centre study
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Belgium
    Nephrol Dial Transplant 19:1281-7. 2004
    ..Our aim was to evaluate the post-transplant natural history of parathyroid function and calcium metabolism in patients with a functional renal graft and to identify risk factors for persistent HPT...
  60. ncbi Long-term results of subtotal vs total parathyroidectomy without autotransplantation in kidney transplant recipients
    Nada Rayes
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow Clinic, Augustenburger Platz 1, 13344 Berlin, Germany
    Arch Surg 143:756-61; discussion 761. 2008
    ..Total parathyroidectomy without autotransplantation in kidney transplant recipients leads to reduced recurrence rates and similar improvement of clinical symptoms compared with subtotal parathyroidectomy...
  61. ncbi Dihydropyridine- and voltage-sensitive Ca2+ entry in human parathyroid cells
    Keitaro Yokoyama
    Department of Nephrology and Hypertension, The Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Exp Physiol 94:847-55. 2009
    ..This Ca(2+) entry system might provide a compensatory pathway for the negative feedback regulation of parathyroid hormone secretion, especially in hyperplastic conditions in which the Ca(2+)-sensing receptor is poorly expressed...
  62. ncbi Biophysical properties of voltage-gated Na+ channels in frog parathyroid cells and their modulation by cannabinoids
    Yukio Okada
    Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki 852 8588, Japan
    J Exp Biol 208:4747-56. 2005
    ..The results suggest that the Na+ currents in frog parathyroid cells can be modulated by cannabinoids via a G protein-dependent mechanism...
  63. ncbi Proliferation in hyperplastic human and normal rat parathyroid glands: role of phosphate, calcitriol, and gender
    Yolanda Almaden
    Unit of Investigation, Hospital Universitario Reina Sofia, Cordoba, Spain
    Kidney Int 64:2311-7. 2003
    ....
  64. ncbi A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    C Ho
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 11:389-94. 1995
    ..Our findings suggest that Casr mutations cause these human disorders by reducing the number of functional receptor molecules on the cell surface...
  65. ncbi Enlarged parathyroid glands discovered in normocalcemic patients during thyroid surgery
    Bassam Abboud
    Department of General Surgery, Hotel Dieu de France Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
    Am J Surg 195:30-3. 2008
    This is a retrospective study analyzing data of normocalcemic patients with enlarged parathyroid glands discovered during thyroid surgery and comparing it with data of patients operated on for proved primary hyperparathyroidism.
  66. ncbi Radionuclide imaging of the parathyroid glands: patterns, pearls, and pitfalls
    Joel R Smith
    Department of Radiology, New England Medical Center and Tufts University School of Medicine, NEMC 299, 750 Washington St, Boston, MA 02111, USA
    Radiographics 24:1101-15. 2004
    ..scintigraphy requires an understanding of (a) the embryologic, anatomic, and physiologic features of the parathyroid glands and (b) the properties of the two common imaging agents, technetium-99m sestamibi and Tc-99m tetrofosmin...
  67. pmc Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia
    Zhijie Liu
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    Dev Biol 305:333-46. 2007
    The parathyroid glands develop with the thymus from bilateral common primordia that develop from the 3rd pharyngeal pouch endoderm in mouse embryos at about E11, each of which separates into one parathyroid gland and one thymus lobe by ..
  68. ncbi Results of cryopreserved parathyroid autografts: a retrospective multicenter study
    Sophie Borot
    Endocrinology Department, University Hospital, Besancon, France
    Surgery 147:529-35. 2010
    ..Moreover, French tissue banks are facing an accumulation of ungrafted samples. The aim of our work was to evaluate the implantation rate of cryopreserved parathyroid samples and the functionality of CPAT in a multicenter study...
  69. pmc Parathyroid hormone is essential for normal fetal bone formation
    Dengshun Miao
    Calcium Research Laboratory, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    J Clin Invest 109:1173-82. 2002
    ..The effect of PTH on fetal osteoblasts may be relevant to its postnatal anabolic effects on trabecular bone...
  70. ncbi Robot assisted transaxillary surgery (RATS) for the removal of thyroid and parathyroid glands
    Christine S Landry
    Department of Surgical Oncology, Section of Surgical Endocrinology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Surgery 149:549-55. 2011
    ..assisted transaxillary surgery (RATS) is a minimally invasive approach for the removal of the thyroid and/or parathyroid glands through the axilla...
  71. ncbi GCMB--another serendipitous gift from evolution to clinical investigators
    Henry M Kronenberg
    J Clin Endocrinol Metab 89:6-7. 2004
  72. ncbi Influence of the parathyroid glands on bone metabolism
    H H Malluche
    University of Kentucky, Lexington, KY 40536, USA
    Eur J Clin Invest 36:23-33. 2006
    ....
  73. pmc Does vitamin D receptor and calcium receptor activation therapy play a role in the histopathologic alterations of parathyroid glands in refractory uremic hyperparathyroidism?
    Carlo Lomonte
    Division of Nephrology, Miulli General Hospital, Acquaviva delle Fonti, Manduria, Italy
    Clin J Am Soc Nephrol 3:794-9. 2008
    ..This study was aimed to assess a possible association between histopathologic changes of parathyroid tissue and treatment modality...
  74. ncbi Activation of calcium-sensing receptor accelerates apoptosis in hyperplastic parathyroid cells
    Masahide Mizobuchi
    Department of Nephrology, School of Medicine, Showa University, Tokyo, Japan
    Biochem Biophys Res Commun 362:11-6. 2007
    ..Hyperplastic parathyroid glands were obtained from uremic rats (subtotal nephrectomy and high-phosphorus diet), and incubated in the media ..
  75. ncbi Total parathyroidectomy with autotransplantation in patients with renal hyperparathyroidism: indications and surgical approach
    Stavros Gourgiotis
    First Surgical Department Organ Transplant Unit, Evangelismos General Hospital, Athens, Greece
    Hormones (Athens) 5:270-5. 2006
    ..the purpose of this retrospective study was the evaluation of the surgical indications, parathyroid histology, and the results of total parathyroidectomy with autotransplantation (Ptx+At) in patients with rH...
  76. ncbi Can calcimimetics inhibit parathyroid hyperplasia? Evidence from preclinical studies
    Tilman Drueke
    Nephrol Dial Transplant 22:1828-39. 2007
  77. ncbi Calcium paradox of aldosteronism and the role of the parathyroid glands
    Alex Vidal
    Division of Cardiovascular Diseases, Univ of Tennessee Health Science Center, 920 Madison Ave, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 290:H286-94. 2006
    ..SHPT plays a permissive role in the proinflammatory vascular phenotype...
  78. ncbi Recent advances in physiological calcium homeostasis
    Indra Ramasamy
    Department of Chemical Pathology, Newham University Hospital, London, UK
    Clin Chem Lab Med 44:237-73. 2006
    ..The former are mainly the kidneys, skeleton, intestine and the parathyroid glands. The latter comprise, amongst others, the parathyroid hormone, vitamin D and calcitonin...
  79. ncbi Incidence and location of ectopic abnormal parathyroid glands
    Roy Phitayakorn
    Department of Surgery, MetroHealth Medical Center, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Am J Surg 191:418-23. 2006
    Ectopic parathyroid glands are a cause for failed parathyroid exploration.
  80. ncbi Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency
    Masahide Mizobuchi
    Center for Blood Purification Therapy, Wakayama Medical University, Japan
    J Am Soc Nephrol 15:2579-87. 2004
    ....
  81. ncbi Rapid intraoperative localization of parathyroid glands utilizing methylene blue infusion
    Daniel B Kuriloff
    Department of Otolaryngology Head and Neck Surgery, St Luke s Roosevelt Hospital Center and Columbia Univeristy College of Physicians and Surgeons, New York, NY 10019 1104, USA
    Otolaryngol Head Neck Surg 131:616-22. 2004
    To review a single surgeon's experience utilizing an intraoperative methylene blue infusion (IMBI) to identify parathyroid glands during neck exploration for primary hyperparathyroidism.
  82. ncbi Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism
    Matthew Colloton
    Department of Metabolic Disorders, Amgen, Inc, Thousand Oaks, California 91320, USA
    Kidney Int 67:467-76. 2005
    ..The present study explores the effects of the calcimimetic cinacalcet HCl on parathyroid hyperplasia, apoptosis, and PTH secretion in a rat model of secondary HPT...
  83. ncbi Parathyroid growth and regression in experimental uremia
    M Taniguchi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, and Kidney Care Unit, Kyushu University, Fukuoka, Japan
    Kidney Int 69:464-70. 2006
    ..In addition, VD(3) treatment could reverse PT hyperplasia and hypertrophy via restoration of these proteins...
  84. ncbi Surgical indications and procedures of parathyroidectomy in patients with chronic kidney disease
    Yoshihiro Tominaga
    Department of Surgery, Renal Center, Nagoya Second Red Cross Hospital, 2 9 Myoken cho Showa ku Nagoya, Japan 4668650
    Ther Apher Dial 9:44-7. 2005
    ..The risk of recurrence is not negligible. Based on our huge experience we believe our strategy for advanced secondary hyperparathyroidism can be accepted at least in Japan...
  85. ncbi Parathyroid glands in calcium regulation and human disease
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    Ann N Y Acad Sci 1040:53-8. 2005
    ..Newly developed vitamin D analogues with reduced calcemic effects and with more pronounced antiproliferative effect may provide new favorable treatment for reversal of HPT...
  86. ncbi Structure of non-(1-84) PTH fragments secreted by parathyroid glands in primary and secondary hyperparathyroidism
    Pierre D'Amour
    Centre de Recherche, Centre hospitalier de l Université de Montréal CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
    Kidney Int 68:998-1007. 2005
    ..We wanted to determine the N structure of non-(1-84) PTH fragments...
  87. ncbi Direct in vitro evidence of the suppressive effect of cinacalcet HCl on parathyroid hormone secretion in human parathyroid cells with pathologically reduced calcium-sensing receptor levels
    Takehisa Kawata
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    J Bone Miner Metab 24:300-6. 2006
    ..Data from this in vitro analysis support the clinical application of cinacalcet in PHPT and SHPT therapy...
  88. ncbi The impact of surgical technique on postoperative hypoparathyroidism in bilateral thyroid surgery: a multivariate analysis of 5846 consecutive patients
    Oliver Thomusch
    Department of General Surgery, Albert Ludwigs University Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Surgery 133:180-5. 2003
    ..Limited information exists about risk factors for postoperative hypoparathyroidism after bilateral thyroid surgery...
  89. ncbi Relation between technetium 99m-methoxyisobutylisonitrile accumulation and multidrug resistance protein in the parathyroid glands
    Satoshi Yamaguchi
    Department of Urology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    World J Surg 26:29-34. 2002
    ..MIBI) scintigraphy has been reported to be a useful method for visualizing the parathyroid glands for the diagnosis of hyperparathyroidism...
  90. ncbi Parathyroid function as a determinant of the response to calcitriol treatment in the hemodialysis patient
    M Rodriguez
    Nephrology Services from the Hospital Universitario Reina Sofia, Cordoba, Spain
    Kidney Int 56:306-17. 1999
    ..Bolus calcitriol (CTR) is used for the treatment of secondary hyperparathyroidism in dialysis patients. Although CTR treatment reduces parathyroid hormone (PTH) levels in many dialysis patients, a significant number fail to respond...
  91. ncbi Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112 5331
    Dev Biol 195:1-15. 1998
    The thymus, thyroid, and parathyroid glands in vertebrates develop from the pharyngeal region, with contributions both from pharyngeal endoderm and from neural crest cells in the pharyngeal arches...
  92. pmc Calcimimetics with potent and selective activity on the parathyroid calcium receptor
    E F Nemeth
    NPS Pharmaceuticals, Inc, 420 Chipeta Way, Salt Lake City, UT 84108, USA
    Proc Natl Acad Sci U S A 95:4040-5. 1998
    ..Calcimimetic compounds could conceivably provide a specific medical therapy for primary hyperparathyroidism...
  93. ncbi Cell biology of parathyroid hyperplasia in uremia
    M Fukagawa
    Division of Nephrology, Tokyo Teishin Hospital and University of Tokyo School of Medicine, Japan
    Am J Med Sci 317:377-82. 1999
    ..Genetic mutations and rearrangements of these cells in nodular hyperplasia remain to be fully elucidated in the near future to establish an effective method for the prevention of parathyroid hyperplasia in uremia...
  94. ncbi Genetic ablation of parathyroid glands reveals another source of parathyroid hormone
    T Gunther
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 406:199-203. 2000
    The parathyroid glands are the only known source of circulating parathyroid hormone (PTH), which initiates an endocrine cascade that regulates serum calcium concentration...
  95. ncbi Cases with fewer than four parathyroid glands in patients with renal hyperparathyroidism at initial parathyroidectomy
    Yatsuka Hibi
    Department of Surgery II, School of Medicine, Nagoya University Hospital, 65 Tsurumai cho Showa ku, Nagoya 466, Japan
    World J Surg 26:314-7. 2002
    ..treatment of secondary hyperparathyroidism (2HPT) due to uremia, it is considered necessary to remove all parathyroid glands from the neck to prevent persistent and recurrent parathyroid hyperfunction...
  96. pmc Fetal parathyroids are not required to maintain placental calcium transport
    C S Kovacs
    Faculty of Medicine Endocrinology, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, Newfoundland A1B 3V6, Canada
    J Clin Invest 107:1007-15. 2001
    ..Hoxa3-null fetuses lack parathyroid glands, and absence of parathyroid hormone (PTH) was confirmed with a rodent PTH immunoradiometric assay...
  97. ncbi Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphate
    A J Brown
    Renal Division, Washington University Medical School, St Louis, Missouri, USA
    Kidney Int 55:1284-92. 1999
    ..The cause of this down-regulation is unknown. Here we examined the roles of uremia and parathyroid hyperplasia on parathyroid gland (PTG) CaR expression in the rat model of renal failure...
  98. ncbi Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D
    Lucie Canaff
    Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 277:30337-50. 2002
    ..In summary, functional VDREs have been identified in the CASR gene and provide the mechanism whereby 1,25(OH)2D up-regulates parathyroid, thyroid C-cell, and kidney CASR expression...
  99. ncbi More than 1,000 cases of total parathyroidectomy with forearm autograft for renal hyperparathyroidism
    Y Tominaga
    Department of Surgery, Renal Center, Nagoya 2nd Red Cross Hospital, Nagoya
    Am J Kidney Dis 38:S168-71. 2001
    ..Based on histopathologic and pathophysiologic investigations, surgical treatment should be considered when parathyroid glands show nodular hyperplasia...
  100. ncbi Supernumerary parathyroid glands: frequency and surgical significance in treatment of renal hyperparathyroidism
    F N Pattou
    Department of General and Endocrine Surgery, University Hospital, 59037 Lille, France
    World J Surg 24:1330-4. 2000
    Supernumerary parathyroid glands (SPGs) are found in 13% of random autopsies. The high incidence of SPGs could explain the persistence or trigger recurrence of renal hyperparathyroidism after surgery...
  101. ncbi Weight of normal parathyroid glands in patients with parathyroid adenomas
    Kathy Yao
    Department of Breast and Endocrine Disease, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    J Clin Endocrinol Metab 89:3208-13. 2004
    ..The weight of normal parathyroid glands removed at surgery in patients with PHP may be greater than that reported in autopsy studies...

Research Grants62

  1. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2013
    ..PPI-induced hypergastrinemia has a direct trophic effect on the parathyroid glands, leading to parathyroid hyperplasia, increased parathyroid hormone secretion and bone loss...
  2. Actions of Parathyroid Hormone (PTH)/PTH Related-Peptide Receptor in Osteocytes
    PAOLA DIVIETI PAJEVIC; Fiscal Year: 2013
    ..Parathyroid hormone (PTH), an 84-amino-acid polypeptide secreted by the parathyroid glands, is a major physiologic regulator of calcium, phosphorous and skeletal homeostasis and, clinically, is the ..
  3. Innovative mouse model to study parathyroids and an application to human disease
    Beate Lanske; Fiscal Year: 2010
    ..This mouse can then be induced to express different genes including siRNAs exclusively in the parathyroid glands through simple intraperitoneal injection of retroviral constructs...
  4. Dominant-negative GCMB mutations cause hypoparathyroidism
    MICHAEL MANNSTADT; Fiscal Year: 2012
    ..Mice with homozygous ablation of Gcm2, one of the two mammalian orthologs, lack parathyroid glands and develop hypocalcemia and hyperphosphatemia...
  5. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2012
    ..mice despite similar serum biochemistry suggesting that Fgf23 has different effects than Klotho on parathyroid glands. Furthermore, we will examine the outcome of intermittent vs...
  6. The Role of GCM2 in Parathyroid Gland Homeostasis
    MICHAEL ALAN LEVINE; Fiscal Year: 2013
    ..cell-specific transcription factor Gcm2 (glial cell missing 2) after early embryologica development of the parathyroid glands as well how this protein functions in mature parathyroid glands to control function and survival of ..
  7. BONE PROPERTIES IN HYPOPARATHYROIDISM: EFFECTS OF PTH
    John P Bilezikian; Fiscal Year: 2013
    ..It is due primarily to surgical removal of all parathyroid tissue or autoimmune destruction of the parathyroid glands. The absence of PTH leads to a reduction in the serum calcium concentration that can be asymptomatic or ..
  8. The Regulation of the Parathyroid Gland
    Beate Lanske; Fiscal Year: 2013
    ..Our second aim is to pursue data we generated from the first ever microarray analysis of mouse parathyroid glands. Our analysis has discovered the expression of some genes in hyperplasic glands that have not been reported ..
  9. Breakthrough intra-operative detection of the parathyroid glands
    Anita Mahadevan-Jansen; Fiscal Year: 2012
    ..This happens because Parathyroid glands are difficult to distinguish from the thyroid and surrounding tissues in the neck...
  10. Modeling of Hyperparathyroidism-Jaw Tumor Syndrome by Targeted Deletion of Hrpt2
    Jessica Costa; Fiscal Year: 2012
    ..are designed to address the mechanisms through which loss of Hrpt2/parafibromin promotes neoplasia in the parathyroid glands and jaws, in the pathophysiologically relevant experimental context of an intact animal...
  11. Molecular mechanisms and epigenetic signatures that specify thymus fate
    Ellen R Richie; Fiscal Year: 2013
    ..5 and E11 during mouse fetal development;the dorsal domain of this pouch gives rise to the parathyroid glands. As the 3rd pp must be patterned into two distinct cell fates, mechanisms must be in place to ensure that ..
  12. GENETIC LINKAGE MAPPING OF FAMILIAL BENIGN HYPERCALCEMIA
    Hunter Heath; Fiscal Year: 1991
    ..normal to slightly elevated plasma parathyroid hormone (PTH) levels, and usually unremarkable parathyroid glands. Subtotal parathyroidectomy does not mitigate the biochemical abnormalities...
  13. DESENSITIZATION AND DOWN REGULATION OF CALCIUM RECEPTORS
    Dolores Shoback; Fiscal Year: 2002
    ..CaR protein expression is reduced in parathyroid glands from patients with primary hyperparathyroidism...
  14. PARATHYROID IMAGING BY RADIOLABELED MONOCLONAL ANTIBODY
    WILLIAM TOLBERT; Fiscal Year: 1990
    ..of this technology would provide surgeons with preoperative knowledge of the precise location(s) of the parathyroid glands, resulting in shorter and more direct surgical procedures which will provide patients with reduced morbidity...
  15. Calcium Sensing Receptor in Human Airway Epithelium
    PHILLIP LAMBERTY; Fiscal Year: 2003
    ..an interesting protein initially characterized in the elucidation of parathyroid hormone release by bovine parathyroid glands. A G-protein coupled receptor, described agonists other than calcium include other polycations (Mg2+, Gd3+), ..
  16. Genetics of Maxillary/Mandibular Discrepancies
    Linda Krebs; Fiscal Year: 2005
    ..Most cases of primary HPT are due to a solitary benign adenoma in one of the parathyroid glands. Molecular allelotyping and CGH have been used to identify areas in the genome where tumor suppressor genes ..
  17. CALCIUM RECEPTOR IN MAMMARY DEVELOPMENT AND PHYSIOLOGY
    Joshua VanHouten; Fiscal Year: 2006
    ..MG) of wild type mice, CaR mice, and CaR-/- mice made viable by the genetically engineered absence of parathyroid glands (CaR-/-/Gcm2-/-)...
  18. Cyclin D1 in oral carcinogenesis
    SANJAY MALLYA; Fiscal Year: 2006
    ..In our mouse model of primary HPT, cyclin D1 deregulation causes hypercellularity and enlargement of the parathyroid glands. However, it has not been established whether these glandular enlargements represent polyclonal ..
  19. Carboxyl-Terminal PTH Receptors in Bone Cell
    F Bringhurst; Fiscal Year: 2006
    ..PTH C-fragments are secreted in a calcium-regulated manner by the parathyroid glands and generated also by peripheral cleavage of intact PTH...
  20. Signaling Complexes in Renal Epithelial Cells
    Richard Miller; Fiscal Year: 2005
    ..is a G protein-coupled receptor that responds to Ca and other polycations to regulate PTH secretion by the parathyroid glands and Ca, NaCI, KCl, and H20 transport in the kidney...
  21. CHARACTERIZATION OF FETOPLACENTAL PTH-LIKE FACTORS
    Lewis Rubin; Fiscal Year: 1990
    ..that circulating PTH-like bioactivity in fetal lambs is partially independent of the presence of the parathyroid glands. Furthermore, it appears that sheep placenta contains PTH-like bioactive factors that may resemble the PTH-..
  22. TWO X-LINKED GENES THAT REGULATE MINERAL HOMEOSTASIS
    Michael Whyte; Fiscal Year: 2002
    ..disorders mapped to the two loci of interest show that one gene is essential for embryogenesis of the parathyroid glands (and thereby maintenance of extracellular fluid calcium levels), and the other gene controls blood phosphate ..
  23. Molecular Pathogenesis of Hyperparathysoidism in Chronic Kidney Diseases
    Kelly Lauter; Fiscal Year: 2010
    ..Through studying their pathologic parathyroid glands, we will aim to uncover mechanisms of this benign aberrant cell growth...
  24. GENETIC BASIS OF HYPERPARATHYRODISM-JAW TUMOR SYNDROME
    Maurine Hobbs; Fiscal Year: 2001
    ..occur in this region of about 250kb, and these will be prioritized for mutation screening by expression in parathyroid glands using an existing parathyroid adenoma library or RT-PCR from parathyroid mRNA...
  25. PTH-RELATED PROTEIN IN THE PANCREATIC ISLET
    Andrew Stewart; Fiscal Year: 2002
    ..should broaden the understanding of the mechanisms of action of PTHrP in the large range of normal tissues (parathyroid glands, the epidermis, the mammary gland, and the skeleton) which produce this ubiquitous paracrine/autocrine/..
  26. Coronary calcification in hemodialysis patients
    William Goodman; Fiscal Year: 2005
    ....
  27. DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILURE
    William Goodman; Fiscal Year: 2001
    ....
  28. Actions of Parathyroid Hormone(PTH)/PTH related-peptide receptor in Osteocytes in
    Paola Divieti; Fiscal Year: 2008
    ..Parathyroid hormone (PTH), an 84-amino-acid polypeptide secreted by the parathyroid glands, is a major physiologic regulator of calcium, phosphorous and skeletal homeostasis and, clinically, is the ..
  29. Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2008
    ..Besides surgery, there are limited curative and palliative treatments available to patients with metastatic NE tumors, emphasizing the need for development of other forms of therapy. [unreadable] [unreadable] [unreadable]..
  30. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2010
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  31. GAMMA INTERFERON REGULATION OF VITAMIN D ACTION
    Adriana Dusso; Fiscal Year: 2002
    ..abstract_text> ..
  32. AMINO AND CARBOXYL TERMINAL PTH RECEPTORS IN OSTEOCYTES
    Paola Divieti; Fiscal Year: 2004
    ..These results could have significant implications for therapy of bone disorders such as hyperparathyroidism, osteoporosis and renal osteodystrophy. ..
  33. Vitamin D Control of TGFa/EFG Receptor Growth Signaling
    Adriana Dusso; Fiscal Year: 2006
    ..By identifying pathogenic mechanisms, these studies should help design more effective therapies for secondary hyperparathyroidism. [unreadable] [unreadable]..
  34. Novel Signaling Targets in GI Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2005
    ..The possibility that raf-l-mediated hormone suppression could be induced by a soluble factor would provide a plausible, therapeutic delivery method. ..
  35. AMINO AND CARBOXYL TERMINAL PTH RECEPTORS IN OSTEOCYTES
    Paola Divieti; Fiscal Year: 2004
    ..These studies will provide new insight into osteocytes and osteoclasts function and of the role of intact, N-terminal and C-terminal PTH in regulating their behavior. ..
  36. Signaling Pathways in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2004
    ..abstract_text> ..
  37. Targeting Bone Remodeling For the Treatment of Osteoporosis
    John Bilezikian; Fiscal Year: 2008
    ..The purpose of this meeting is to bring together experts from these interdisciplinary fields so as to define the direction of the future. ..
  38. CA2+ SENSING RECEPTOR EXPRESSION IN HYPERPARATHYROIDISM
    Alex Brown; Fiscal Year: 2002
    b>Parathyroid glands (PTGs) express a calcium-sensing receptor (CaR) that detects the concentration of extracellular calcium and signals the glands to secrete the proper amount of parathyroid hormone (PTH) to maintain normal calcium levels...
  39. PHARMACOLOGY OF BOVINE PARATHYROID CA++ RECEPTORS
    Edward M Brown; Fiscal Year: 2002
    ....
  40. Phase I Serum-free cultured thymus transplantation in DiGeorge anomaly, IND9836,
    MARY MARKERT; Fiscal Year: 2009
    ..The focus of these experiments is the development of thymopoiesis and normal presentation of promiscuously expressed antigens in the thymus. ..
  41. Dose Study of thymus Transplantation
    MARY MARKERT; Fiscal Year: 2007
    ..Abstract Not Provided. ..
  42. CALCIUM RECEPTOR SIGNAL RECOGNITION AND TRANSDUCTION
    Edward M Brown; Fiscal Year: 2006
    ..abstract_text> ..
  43. CA2+ RECEPTOR, PTHRP & MALIGNANCY-INDUCED OSTEOLYSIS
    Edward M Brown; Fiscal Year: 2004
    ..abstract_text> ..
  44. PET Imaging of the Pancreas in Murine Models of Diabetes
    Paige Clark; Fiscal Year: 2005
    ..The method could also be useful in evaluating the function of pancreatic transplants and successful engraftment of transplanted progenitor or beta cells. ..
  45. INHIBITION OF PTH SECRETION: CaR AND THE CYTOSKELETON
    Edward M Brown; Fiscal Year: 2007
    ..Phosphorylation of caveolin-1 under high Ca 2+ conditions may anchor the CaR-PTH unit to the plasma membrane, limiting PTH secretion. ..
  46. Dynamics of TCR Repertoire Following Thymus Transplant
    MARY MARKERT; Fiscal Year: 2008
    ..Infants with DiGeorge syndrome are born with defects in the thymus, heart, and parathyroid glands. Patients with "complete" DiGeorge syndrome have no evidence ofthymic function...
  47. Parathyroid and Thymus Transplants in DiGeorge Syndrome
    MARY MARKERT; Fiscal Year: 2005
    ..Indirect allorecognition as a mechanism of graft rejection will be assessed by ELISpot. The third aim will assess safety and tolerability. ..
  48. CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITRO
    Edward M Brown; Fiscal Year: 2007
    ..3) To develop an animal model of activating and/or inactivating antibodies by immunization with the CaR's extracellular domain. [unreadable] [unreadable]..
  49. PRIMARY HYPERPARATHYROIDISM: NON-CLASSICAL MANIFESTATIONS
    Shonni Silverberg; Fiscal Year: 2009
    ..abstract_text> ..
  50. GENETICS OF FAMILIAL FOCAL SEGMENTAL GLOMERULOSCLEROSIS
    L Quarles; Fiscal Year: 2002
    ..Knowledge derived from FFSGS will also allow a better understanding of pathogenesis of non-hereditary forms FSGS and may provide insights regarding management of the more common sporadic forms of this disorder. ..
  51. Improving genomic prediction models in breast cancer
    John Olson; Fiscal Year: 2005
    ....
  52. Mechanisms of cervical thymus development
    Nancy Manley; Fiscal Year: 2008
    ..If it is the latter, this raises the intriguing possibility that latent thymic potential may exist in everyone, and thus may represent a novel therapeutic target for thymic regeneration and rebound. [unreadable] [unreadable] [unreadable]..
  53. Physiological Model of Parathyroid Hormone Secretion
    Danny Petrasek; Fiscal Year: 2006
    ..In a broader view, our preliminary results suggest that in addition to the cellular mechanisms, glandular networks may have regulatory prowess at the level of interstitial transport. ..
  54. Regulation of thymic epithelial cell differentiation
    Nancy Manley; Fiscal Year: 2007
    ..Further, our identification of a new function for the N-terminal domain may have implications for functional domains in other forkhead family transcription factors. ..
  55. EXTRACELLULAR CALCIUM-SENSING RECEPTORS IN OSTEOBLASTS
    L Quarles; Fiscal Year: 2009
    ..Successful completion of this project is certain to yield important new knowledge regarding the function of GPRC6A. ..
  56. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 2005
    ..The biochemical studies will be correlated with electrophysiological recording of channel activity. ..
  57. Genetic analysis of thymus organogenesis
    Nancy Manley; Fiscal Year: 2007
    ..goal of this research is to understand the molecular mechanisms controlling organogenesis of the thymus and parathyroid glands in mice...