adrenal medulla

Summary

Summary: The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.

Top Publications

  1. pmc Identifying the stress transcriptome in the adrenal medulla following acute and repeated immobilization
    Xiaoping Liu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    Ann N Y Acad Sci 1148:1-28. 2008
  2. ncbi Neural plasticity occurs in the adrenal medulla of asthmatic rats
    Jun Tao Feng
    Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
    Chin Med J (Engl) 123:1333-7. 2010
  3. pmc Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice
    E Moura
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Alameda Prof Hernani Monteiro, Porto, Portugal
    Br J Pharmacol 149:1049-58. 2006
  4. ncbi A bipotential neuroendocrine precursor whose choice of cell fate is determined by NGF and glucocorticoids
    D J Anderson
    Cell 47:1079-90. 1986
  5. ncbi The development of the chromaffin cell lineage from the neural crest
    Katrin Huber
    Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg, Germany
    Auton Neurosci 151:10-6. 2009
  6. ncbi Maternal perinatal undernutrition alters postnatal development of chromaffin cells in the male rat adrenal medulla
    Olivier Molendi-Coste
    Unité de Neurosciences et Physiologie Adaptatives, UPRES EA 4052, Equipe dénutritions maternelles périnatales, SN4, Universite de Lille I, Villeneuve d Ascq, France
    Neuroendocrinology 90:54-66. 2009
  7. ncbi Isolation of neural crest derived chromaffin progenitors from adult adrenal medulla
    Kuei Fang Chung
    Carl Gustav Carus University Medical School, Medical Clinic III, Dresden University of Technology, Dresden, Germany
    Stem Cells 27:2602-13. 2009
  8. pmc Asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla
    Xiu Ming Wu
    Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
    PLoS ONE 6:e20337. 2011
  9. pmc ProxTom lymphatic vessel reporter mice reveal Prox1 expression in the adrenal medulla, megakaryocytes, and platelets
    Lucy A Truman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Am J Pathol 180:1715-25. 2012
  10. ncbi A new focus on interoceptive properties of adrenal medulla
    Boris Mravec
    Institute of Experimental Endocrinology, Slovak Academy of Sciences and Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic
    Auton Neurosci 120:10-7. 2005

Research Grants

  1. Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome
    JON DAVID LEVINE; Fiscal Year: 2013
  2. Exocytosis and Coupled Endocytosis in Neuroendocrine Cells
    JOHN DAVID CASTLE; Fiscal Year: 2010
  3. Mechanism for Reduced Adrenomedullary Epinephrine Release in Type 1 Diabetes
    BRANLY OSVALDO ORBAN; Fiscal Year: 2012
  4. Development of the renin-expressing cell
    Maria L Sequeira Lopez; Fiscal Year: 2010
  5. Nicotinic acetylcholine receptors and neuroblastoma
    Rae Nishi; Fiscal Year: 2012
  6. Interaction of RGS Protein with G beta subunit G beta 5.
    Vladlen Z Slepak; Fiscal Year: 2013
  7. Integrative Consequences of Hypoxia
    Nanduri R Prabhakar; Fiscal Year: 2013
  8. NTS Adenosine Receptors in Cardiovascular Control
    DONAL S O apos LEARY; Fiscal Year: 2010
  9. Transcription Factors in Neuroendocrine Differentiation
    Michael Lan; Fiscal Year: 2009
  10. MOLECULAR GENETICS OF SENSORY ORGAN DEVELOPMENT
    James W Posakony; Fiscal Year: 2013

Detail Information

Publications267 found, 100 shown here

  1. pmc Identifying the stress transcriptome in the adrenal medulla following acute and repeated immobilization
    Xiaoping Liu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    Ann N Y Acad Sci 1148:1-28. 2008
    ..The full repertoire of genes whose expression in the adrenal medulla is altered by stress has not been previously determined. In this study, gene profiling (RAE 230 2...
  2. ncbi Neural plasticity occurs in the adrenal medulla of asthmatic rats
    Jun Tao Feng
    Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
    Chin Med J (Engl) 123:1333-7. 2010
    ..The aim of this study was to monitor the neuroendocrine alteration in the adrenal medulla of asthmatic rats.
  3. pmc Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice
    E Moura
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Alameda Prof Hernani Monteiro, Porto, Portugal
    Br J Pharmacol 149:1049-58. 2006
    This study was carried out to elucidate which alpha(2)-adrenoceptor subtypes mediated the inhibition of noradrenaline and adrenaline release from the adrenal medulla of mice.
  4. ncbi A bipotential neuroendocrine precursor whose choice of cell fate is determined by NGF and glucocorticoids
    D J Anderson
    Cell 47:1079-90. 1986
    ..We have found that the embryonic adrenal medulla and sympathetic ganglia are both initially populated by precursors expressing neural-specific genes...
  5. ncbi The development of the chromaffin cell lineage from the neural crest
    Katrin Huber
    Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg, Germany
    Auton Neurosci 151:10-6. 2009
    ....
  6. ncbi Maternal perinatal undernutrition alters postnatal development of chromaffin cells in the male rat adrenal medulla
    Olivier Molendi-Coste
    Unité de Neurosciences et Physiologie Adaptatives, UPRES EA 4052, Equipe dénutritions maternelles périnatales, SN4, Universite de Lille I, Villeneuve d Ascq, France
    Neuroendocrinology 90:54-66. 2009
    ..This might contribute to the long-lasting malprogramming of the adrenal medulla and to the development of chronic adult diseases.
  7. ncbi Isolation of neural crest derived chromaffin progenitors from adult adrenal medulla
    Kuei Fang Chung
    Carl Gustav Carus University Medical School, Medical Clinic III, Dresden University of Technology, Dresden, Germany
    Stem Cells 27:2602-13. 2009
    Chromaffin cells of the adrenal medulla are neural crest-derived cells of the sympathoadrenal lineage. Unlike the closely-related sympathetic neurons, a subpopulation of proliferation-competent cells exists even in the adult...
  8. pmc Asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla
    Xiu Ming Wu
    Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
    PLoS ONE 6:e20337. 2011
    Adrenal neuroendocrine plays an important role in asthma. The activity of the sympathoadrenal system could be altered by early life events. The effects of maternal asthma during pregnancy on the adrenal medulla of offspring remain unknown.
  9. pmc ProxTom lymphatic vessel reporter mice reveal Prox1 expression in the adrenal medulla, megakaryocytes, and platelets
    Lucy A Truman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Am J Pathol 180:1715-25. 2012
    ..fluorescent mice revealed the expression of Prox1 in three novel sites: the neuroendocrine cells of the adrenal medulla, megakaryocytes, and platelets. The novel sites identified herein suggest previously unknown roles for Prox1...
  10. ncbi A new focus on interoceptive properties of adrenal medulla
    Boris Mravec
    Institute of Experimental Endocrinology, Slovak Academy of Sciences and Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic
    Auton Neurosci 120:10-7. 2005
    The adrenal medulla is an important part of the sympathoadrenal system. Chromaffin cells of the adrenal medulla respond to a broad spectrum of stressful situations by releasing epinephrine and norepinephrine...
  11. pmc Post-transcriptional regulation of tyrosine hydroxylase expression in adrenal medulla and brain
    A William Tank
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann N Y Acad Sci 1148:238-48. 2008
    ..well established that long-term stress leads to induction of tyrosine hydroxylase (TH) mRNA and TH protein in adrenal medulla and brain. This induction is usually associated with stimulation of the TH gene transcription rate...
  12. ncbi Gene expression of phenylethanolamine N-methyltransferase in corticotropin-releasing hormone knockout mice during stress exposure
    R Kvetnansky
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Cell Mol Neurobiol 26:735-54. 2006
    ..1.1.28) is primarily localized in the adrenal medulla (AM)...
  13. ncbi Adrenal adrenaline- and noradrenaline-containing cells and celiac sympathetic ganglia are differentially controlled by centrally administered corticotropin-releasing factor and arginine-vasopressin in rats
    Naoko Yamaguchi-Shima
    Department of Pharmacology, Graduate School of Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Eur J Pharmacol 564:94-102. 2007
    ..The adrenal medulla has two separate populations of chromaffin cells, adrenaline-containing cells (A-cells) and noradrenaline-..
  14. ncbi Dysfunction of releasing adrenaline in asthma by nerve growth factor
    Jun Tao Feng
    Department of Respiratory Medicine, Xiangya Hospital, Central South University, No 141 XiangYa Road, Changsha, Hunan 410008, China
    Med Hypotheses 65:1043-6. 2005
    In early embryo period, adrenal medulla development is parallel with adrenergic nerves. For this reason, adrenal medullary cells may be provided with potential ability of transdifferentiation toward nerve cells...
  15. ncbi Programming of sympathoadrenal function
    James B Young
    Northwestern University Chicago, Ward Building 4 161, 303 East Chicago Avenue, Chicago, IL 60611 3008, USA
    Trends Endocrinol Metab 13:381-5. 2002
    ..The sympathetic innervation of peripheral tissues and the responsiveness of sympathetic nerves and adrenal medulla to standard stimuli are susceptible to modification by exposures in early life, such as environmental ..
  16. ncbi Cell therapy of pain: Characterization of human fetal chromaffin cells at early adrenal medulla development
    H Zhou
    Laboratory of Pain and Cell Therapy, 133 route de Narbonne, 31062 Toulouse Cedex, France
    Exp Neurol 198:370-81. 2006
    ..These observations on the expression of these biological factors indicate that 9-10 GW would be the best stage for sampling these cells for preclinical transplantation experiments...
  17. ncbi Useful cell lines derived from the adrenal medulla
    M J Eaton
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, 1095 N W 14th Terrace R 48, Miami, FL 33136, USA
    Mol Cell Endocrinol 228:39-52. 2004
    ..Eventually, as we increase our understanding of regulating the phenotypic fate of chromaffin cells in vitro, stem or progenitor adrenal medullary cell lines will be derived as an alternative source for expansion and clinical use...
  18. ncbi An uncommon type of adrenal incidentaloma: a case report of a schwannoma of the adrenal medulla with cytological, histological, and ultrastructural correlation
    Joseph D Jakowski
    Department of Pathology, Broady School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Ann Diagn Pathol 12:356-61. 2008
    ..We report a case of a schwannoma of the adrenal medulla in an asymptomatic 51-year-old woman, which was discovered incidentally on a computed tomography scan after ..
  19. ncbi Myosin VI is associated with secretory granules and is present in the nucleus in adrenal medulla chromaffin cells
    Łukasz Majewski
    Department of Biochemistry, Nencki Institute of Experimental Biology, Warszawa, Poland
    Acta Biochim Pol 57:109-14. 2010
    ..The presented data indicate that MVI in adrenal medulla cells is engaged in secretory vesicle trafficking within the cytoplasm and possibly also involved in ..
  20. ncbi Chromaffin progenitor cells from the adrenal medulla
    Monika Ehrhart-Bornstein
    University Clinic Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    Cell Mol Neurobiol 30:1417-23. 2010
    Chromaffin cells of the adrenal medulla are neural crest-derived cells of the sympathoadrenal lineage...
  21. ncbi Social stress alters expression of large conductance calcium-activated potassium channel subunits in mouse adrenal medulla and pituitary glands
    O Chatterjee
    Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    J Neuroendocrinol 21:167-76. 2009
    ..In younger animals, Slo-alpha mRNA levels were elevated 44% and 116% in the adrenal medulla and pituitary, respectively, compared to individually-housed controls...
  22. ncbi Different effects of insulin and 2-deoxy-D-glucose administration on tyrosine hydroxylase gene expression in the locus coeruleus and the adrenal medulla in rats
    M Rusnak
    Institute of Experimental Endocrinology Slovak Academy of Sciences, Bratislava
    Brain Res Bull 46:447-52. 1998
    ..catecholamine biosynthesis, by in situ hybridization in locus coeruleus and by Northern blot analysis in the adrenal medulla of rats...
  23. ncbi Neuropeptide W is expressed in the noradrenalin-containing cells in the rat adrenal medulla
    Mayumi Seki
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai Shinagawa ku, Tokyo 142 8555, Japan
    Regul Pept 145:147-52. 2008
    ..of NPW mRNA in these tissues, while in situ hybridization demonstrated the presence of NPW mRNA in the adrenal medulla. When immunohistochemistry was performed on sections of adrenal gland, NPW-like immunoreactivity (NPW-LI) was ..
  24. ncbi Nucleotide sequence analysis of cDNAs encoding a bovine galanin precursor protein in the adrenal medulla and chemical isolation of bovine gut galanin
    A Rokaeus
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD
    FEBS Lett 234:400-6. 1988
    ..Northern blot analysis revealed the presence of an apparent single galanin mRNA species, of approx. 850-900 bases in size, which was present in a population of chromaffin cells scattered throughout the bovine adrenal medulla.
  25. ncbi Programming of rat adrenal medulla by neonatal hyperleptinemia: adrenal morphology, catecholamine secretion, and leptin signaling pathway
    I H Trevenzoli
    Departamento de Ciencias Fisiologicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, 20551 030, Brazil
    Am J Physiol Endocrinol Metab 298:E941-9. 2010
    ..In conclusion, high leptin levels on lactation program the activity of the sympathoadrenal system at adulthood that may contribute to the development of adult chronic diseases such as hypertension...
  26. ncbi Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: an in vivo analysis
    Larisa Bobrovskaya
    School of Biomedical Sciences, The University of Newcastle, Callaghan, New South Wales, Australia
    Neurochem Int 57:162-7. 2010
    ..Here we explored the effects on, TH phosphorylation and synthesis, and upstream signalling pathways, in the adrenal medulla evoked by the glucoprivic stimulus, 2-deoxy-d-glucose (2DG) administered intraperitoneally to conscious rats...
  27. ncbi Influence of polyphenolic compounds isolated from Rubus coreanum on catecholamine release in the rat adrenal medulla
    Young Woo Kee
    Department of Pharmacology, College of Medicine, Chosun University, Gwangju 501 759, Korea
    Arch Pharm Res 30:1240-51. 2007
    ..from Rubus coreanum MIQUEL (PCRC) may affect the release of catecholamine (CA) from the isolated perfused rat adrenal medulla, and to establish its mechanism of action...
  28. ncbi Subcellular distribution studies of diadenosine polyphosphates--Ap4A and Ap5A--in bovine adrenal medulla: presence in chromaffin granules
    A Rodriguez Del Castillo
    Departamento de Bioquimica, Facultad de Medicina, Universidad de La Laguna, Islas Canarias, Spain
    J Neurochem 51:1696-703. 1988
    ..The cytosolic fraction also contains enzymatic activities that degrade Ap4A as well as Ap5A. These activities were measured by an HPLC method; the observed Km values were 10.5 +/- 0.5 and 13 +/- 1 microM for Ap4A and Ap5A, respectively...
  29. ncbi Stress triggered changes in gene expression in adrenal medulla: transcriptional responses to acute and chronic stress
    Esther L Sabban
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    Cell Mol Neurobiol 26:845-56. 2006
    ..changes in levels of phospho-CREB (P-CREB), phospho-ERK1/2 (P-ERK1/2) and Fra-2 by Western Blot analysis in adrenal medulla of Sprague Dawley male rats exposed to single or repeated immobilization stress (IMO)...
  30. pmc Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress
    Ganesh K Kumar
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4935, USA
    J Physiol 575:229-39. 2006
    ..In the present study, we examined whether CIH induces hypoxic sensitivity in the adult rat adrenal medulla and, if so, by what mechanism(s)...
  31. ncbi Tyrosine hydroxylase, chromogranin A, and steroidogenic acute regulator as markers for successful separation of human adrenal medulla
    Stephanie M J Fliedner
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Tissue Res 340:607-12. 2010
    ..This is difficult to obtain from pheochromocytomas (PHEOs), rare chromaffin tumors derived from adrenal medulla. The two options for obtaining adrenal tissue are: (1) whole organ removal post-mortem or during radical ..
  32. ncbi A physiological view of the central and peripheral mechanisms that regulate the release of catecholamines at the adrenal medulla
    A M G de Diego
    Instituto Teofilo Hernando, Departamento de Farmacologia y Terapeutica, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    Acta Physiol (Oxf) 192:287-301. 2008
    ..This, together with the use of adrenal slices and transmural electrical stimulation of splanchnic nerves will provide new physiologically sound data on the regulation of adrenal medullary secretion...
  33. ncbi Organization, fine structure, and viability of the human adrenal medulla: considerations for neural transplantation
    J T Hansen
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, NY 14642
    Ann Neurol 24:599-609. 1988
    ..In this study, we determined the general morphological characteristics of the human adrenal medulla and assessed factors important for the maintenance of cultured chromaffin cells for later use as transplants...
  34. ncbi Vitamin D3-induced proliferative lesions in the rat adrenal medulla
    A S Tischler
    Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Toxicol Sci 51:9-18. 1999
    ..D3 model to prospectively test the relationship between mitogenicity and focal proliferative lesions in the adrenal medulla and to determine early events in the pathogenesis of these lesions...
  35. ncbi Effects of systemic PSI administration on catecholaminergic cells in the brain, adrenal medulla and carotid body in Wistar rats
    Alexander Hawlitschka
    Institute of Anatomy, Faculty of Medicine, University of Rostock, POB 100888, 18055 Rostock, Germany
    Brain Res 1173:137-44. 2007
    ..The proteasome inhibitor effect on the glomerular layer of the olfactory bulb, the adrenal medulla and the carotid body was examined...
  36. ncbi Central stresscopin modulates cardiovascular function through the adrenal medulla in conscious rats
    Chun Ping Chu
    Department of Physiology, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki gun, Miyazaki 889 1692, Japan
    Regul Pept 119:53-9. 2004
    ..5 nmol) did not elicit significant changes in MABP and HR. Therefore, these data suggest that centrally administered SCP modulates cardiovascular function, likely through the sympatho-adrenal-medullary (SAM) system...
  37. ncbi α₂-Adrenoceptor-mediated inhibition of catecholamine release from the adrenal medulla of spontaneously hypertensive rats is preserved in the early stages of hypertension
    Eduardo Moura
    Faculty of Medicine, Institute of Pharmacology and Therapeutics, University of Porto, Porto, Portugal
    Basic Clin Pharmacol Toxicol 109:253-60. 2011
    In this study, we evaluated the effect of α(2) -adrenoceptor activation on catecholamine release from the adrenal medulla of pre-hypertensive (6-week-old) and hypertensive (16-week-old) spontaneously hypertensive rats (SHR) and of age-..
  38. ncbi Nitric oxide is involved in lithium-induced immediate early gene expressions in the adrenal medulla
    Jeong Won Jahng
    Department of Pharmacology, Yonsei Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, South Korea
    Eur J Pharmacol 489:111-6. 2004
    ..suggest that nitric oxide is, at least partly, involved in lithium-induced c-Fos/ICER expression in the adrenal medulla, and that central nitric oxide may play a different role from peripheral nitric oxide in lithium-induced ..
  39. ncbi Maternal perinatal undernutrition has long-term consequences on morphology, function and gene expression of the adrenal medulla in the adult male rat
    C Laborie
    Unité Environnement Périnatal et Croissance, EA 4489, Universite Lille Nord de France, Equipe Dénutritions Remplace by Maternelles Périnatales, Université Lille1, Villeneuve d Ascq, France
    J Neuroendocrinol 23:711-24. 2011
    ..disturbs chromaffin cells organisation and activity in male rats at weaning, its long-term effects on adrenal medulla in adult animals are unknown...
  40. ncbi Spinal allografts of adrenal medulla block nociceptive facilitation in the dorsal horn
    I D Hentall
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurophysiol 85:1788-92. 2001
    ..Rats were given adrenal medulla allografts, or, as controls, striated-muscle allografts...
  41. ncbi Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla
    Stephan Oberle
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 26:1823-32. 2006
    ..as suggested by its capacity to prevent their death after destruction of one of their major targets, the adrenal medulla. Although somatic motoneurons and PSNs share a common embryonic origin, they are distinct in several respects,..
  42. pmc A continuous-wave electron-nuclear double resonance (X-band) study of the Cu2+ sites of particulate methane mono-oxygenase of Methylococcus capsulatus (strain M) in membrane and pure dopamine beta-mono-oxygenase of the adrenal medulla
    Bettina Katterle
    Department of Biochemistry, University of Oslo, P O Box 1041 Blindern, N 0316 Oslo, Norway
    Biochem J 363:677-86. 2002
    ..In conclusion, the resting EPR visible Cu in pMMO is not part of a trinuclear cluster, as has been suggested previously...
  43. pmc The innervation of the adrenal gland. IV. Innervation of the rat adrenal medulla from birth to old age. A descriptive and quantitative morphometric and biochemical study of the innervation of chromaffin cells and adrenal medullary neurons in Wistar rats
    A Tomlinson
    Department of Human Morphology, Queen s Medical Centre, University of Nottingham
    J Anat 169:209-36. 1990
    The innervation of the adrenal medulla has been investigated in normal Wistar rats from birth to old age and ultrastructural findings compared with biochemical markers of the cholinergic innervation of the adrenal gland and catecholamine ..
  44. ncbi Stress-induced changes in epinephrine expression in the adrenal medulla in vivo
    T C Tai
    Department of Psychiatry, Harvard Medical School and the Laboratory of Molecular and Developmental Neurobiology, McLean Hospital, Belmont, MA 02478, USA
    J Neurochem 101:1108-18. 2007
    Immobilization (IMMO) stress was used to examine how stress alters the stress hormone epinephrine (EPI) in the adrenal medulla in vivo. In rats subjected to IMMO for 30 or 120 min, adrenal corticosterone increased to the same extent...
  45. ncbi Dispensable role of protein 4.1B/DAL-1 in rodent adrenal medulla regarding generation of pheochromocytoma and plasmalemmal localization of TSLC1
    Nobuhiko Ohno
    Department of Anatomy and Molecular Histology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    Biochim Biophys Acta 1793:506-15. 2009
    ..1B-knockout mice. Although plasmalemmal immunolocalization of 4.1B was shown in chromaffin cells of rodent adrenal medulla, expression of 4...
  46. ncbi Multiple complexes involved in tyrosine hydroxylase mRNA stability in rat adrenal medulla, after reserpine stimulation
    J Alterio
    , CNRS UMR C9923, , , 83, , Paris, 75013, France
    Mol Cell Neurosci 17:179-89. 2001
    ..of TH mRNA, allows the binding of a cytosolic protein to this 28-mer site in the TH 3'UTR in the rat adrenal medulla. An ex vivo kinetic analysis shows that the resulting 54-kDa ribonucleoprotein is early induced by reserpine...
  47. ncbi Steroid regulation of monoamine oxidase activity in the adrenal medulla
    M B Youdim
    Laboratory of Cell Biology and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, Maryland 20892
    FASEB J 3:1753-9. 1989
    ..of different steroid hormones in vivo has distinct and specific effects on the MAO activity of the adrenal medulla. In an effort to reconstitute these effects in defined cells, we have isolated endothelial cells and ..
  48. ncbi Swim training applied at early age is critical to adrenal medulla catecholamine content and to attenuate monosodium L-glutamate-obesity onset in mice
    D X Scomparin
    Laboratory of Secretion Cell Biology, Department of Cell Biology and Genetics, State University of Maringa, Av Colombo 5790, Bloco H 67, S 019, 87020 900 Maringa PR Brazil
    Life Sci 79:2151-6. 2006
    ..We conclude that metabolic changes imposed by early exercise, leading to an attenuation of MSG-hypothalamic obesity onset, are at least in part due to sympathoadrenal activity modulation...
  49. ncbi Diminished epinephrine excretion in genetically obese (ob/ob) mice and monosodium glutamate-treated rats
    F S Leigh
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611
    Int J Obes Relat Metab Disord 16:597-604. 1992
    ..These findings indicate that secretion of Epi by the adrenal medulla is diminished, but is normally responsive to stimulation in these two models of animals obesity, and are thus ..
  50. pmc Vacuolar sequential exocytosis of large dense-core vesicles in adrenal medulla
    Takuya Kishimoto
    Division of Biophysics, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    EMBO J 25:673-82. 2006
    Individual exocytic events in intact adrenal medulla were visualized by two-photon extracellular polar-tracer imaging...
  51. ncbi Processing of chromogranin B in bovine adrenal medulla. Identification of secretolytin, the endogenous C-terminal fragment of residues 614-626 with antibacterial activity
    J M Strub
    Institut National de la Sante et de la Recherche Medicale, Unité 338 de Biologie de la Communication Cellulaire, Strasbourg, France
    Eur J Biochem 229:356-68. 1995
    ..In addition, the synthetic peptide was unable to induce hemolytic activity. This antibacterial function might be of biological significance in the neuroendocrine system of living organisms. We propose to name this peptide secretolytin...
  52. ncbi Development and plasticity of adrenal chromaffin cells: cues based on in vitro studies
    H D Hofmann
    Max Planck Institut for Brain Research, Frankfurt, Federal Republic of Germany
    J Electron Microsc Tech 12:397-407. 1989
    ..ultrastructural, and biochemical characteristics: principal sympathetic neurons and chromaffin cells of the adrenal medulla. The present article reviews experimental studies performed on cultured adrenal medullary cells and designed ..
  53. pmc Central injection of nitric oxide synthase inhibitors increases peripheral interleukin-6 and serum amyloid A: involvement of adrenaline from adrenal medulla
    D K Song
    Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University, Chunchon, 200 702, South Korea
    Br J Pharmacol 130:41-8. 2000
    ..v.) induced an increase in IL-6 mRNA expression in liver, spleen, and lymph node. 8. These results suggest that NOS activity in the brain tonically down-regulates peripheral IL-6 by inhibiting adrenaline release from the adrenal medulla.
  54. ncbi Different adrenal sympathetic preganglionic neurons regulate epinephrine and norepinephrine secretion
    S F Morrison
    Department of Physiology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Am J Physiol Regul Integr Comp Physiol 279:R1763-75. 2000
    ..a foundation for identifying the different sympathetic networks underlying the differential regulation of epinephrine and norepinephrine secretion from the adrenal medulla in response to physiological challenges and experimental stimuli.
  55. ncbi Stimulatory effect of phenylephrine on the secretion of beta-endorphin from rat adrenal medulla in vitro
    J T Cheng
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
    Auton Neurosci 93:31-5. 2001
    ..was employed to investigate the effect on secretion of beta-endorphin-like immunoreactivity (BER) from adrenal medulla of rat in vitro...
  56. ncbi Adrenal medullary function and expression of catecholamine-synthesizing enzymes in mice with hypothalamic obesity
    Andréia C P Martins
    Department of Cell Biology and Genetics, State University of Maringa, Maringa, PR, Brazil
    Life Sci 74:3211-22. 2004
    ..0% lower in the obese group when compared to lean controls (P < 0.0001). Using isolated adrenal medulla we observed no difference in basal catecholamine secretion percentile between obese and lean animals...
  57. ncbi Development of chromaffin cells depends on MASH1 function
    Katrin Huber
    Neuroanatomy, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
    Development 129:4729-38. 2002
    ..Mash1 knockout mice display severe deficits in sympathetic ganglia, yet their adrenal medulla has been reported to be largely normal suggesting that MASH1 is essential for neuronal but not for ..
  58. ncbi Cross-talk between adrenal medulla and adrenal cortex in stress
    Monika Ehrhart-Bornstein
    Department of Medicine, University of Dresden, Dresden, Germany
    Ann N Y Acad Sci 1148:112-7. 2008
    ..of the endocrine system to stress is characterized by the concomitant release of catecholamines from the adrenal medulla and of glucocorticoids from the adrenal cortex...
  59. ncbi Prior hypoglycemia enhances glucose responsiveness in some ventromedial hypothalamic glucosensing neurons
    Ling Kang
    Department of Neurology and Neurosciences, New Jersey Medical School, University of Medicine and Dentistry, Newark, New Jersey, USA
    Am J Physiol Regul Integr Comp Physiol 294:R784-92. 2008
    ..5 mmol/l glucose. These data suggest that the increased VMH glucokinase after IIH may contribute to the increased responsiveness of VMH glucosensing neurons to glucose and the associated blunting of the AMR...
  60. ncbi Fetal adrenal medulla catecholamine response to hypoxia-direct and neural components
    C Y Cheung
    Department of Reproductive Medicine, University of California, San Diego, School of Medicine, La Jolla 92093
    Am J Physiol 258:R1340-6. 1990
    ..These results suggest that in unanesthetized ovine fetuses a direct response of the adrenal medulla to hypoxia is present at 110 days gestation...
  61. ncbi An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes
    W H Busby
    J Biol Chem 262:8532-6. 1987
    ..In preliminary studies, we find that over 90% of the enzyme in bovine adrenal medulla is contained in the soluble chromaffin vesicle fraction...
  62. ncbi Chronic nicotine treatment leads to sustained stimulation of tyrosine hydroxylase gene transcription rate in rat adrenal medulla
    Baoyong Sun
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Pharmacol Exp Ther 304:575-88. 2003
    ..we have studied the mechanisms by which short-term nicotine treatment regulates tyrosine hydroxylase (TH) in adrenal medulla. In this report, we study the effects of chronic nicotine treatment on adrenal TH gene expression...
  63. ncbi Identification and subcellular localization of the Na+/H+ exchanger and a novel related protein in the endocrine pancreas and adrenal medulla
    Pierre Moulin
    Unit of Pathology, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    J Mol Endocrinol 38:409-22. 2007
    ..diffusely stained the cytoplasm of insulin, glucagon and somatostatin cells as well as endocrine cells of the adrenal medulla. Electron microscopy localized the NHE1 immunoreactivity in the membrane of secretory granules, an unexpected ..
  64. ncbi Histogenesis and morphofunctional characteristics of chromaffin cells
    L Diaz-Flores
    Department of Pathology and Histology, School of Medicine, La Laguna University, Canary Islands, Spain
    Acta Physiol (Oxf) 192:145-63. 2008
    ..status of research about the histogenesis and morphofunctional characteristics of chromaffin cells in the adrenal medulla. First, this study reports the selective migration, transcription and activation factors, and the ..
  65. ncbi Intracerebral adrenal medulla grafts: a review
    W J Freed
    Preclinical Neurosciences Section, NIMH Neuroscience Center, St Elizabeths, Washington, D C 20032
    Exp Neurol 110:139-66. 1990
    This review summarizes basic and clinical research on intracerebral adrenal medulla grafts, emphasizing potential applications to Parkinson's disease...
  66. pmc Comparative gene expression profile of mouse carotid body and adrenal medulla under physiological hypoxia
    M D Ganfornina
    Departamento de Bioquímica y Fisiología y Genética Molecular IBGM, Universidad de Valladolid CSIC, 47005 Valladolid, Spain
    J Physiol 566:491-503. 2005
    ..obtained under these environmental conditions were subtracted from the profile of control non-chemoreceptor adrenal medulla extracted from the same animals...
  67. ncbi Role of proto-oncogenes in the regulation of proenkephalin mRNA expression induced by repeated nicotine injections in rat adrenal medulla
    Yung Hi Kim
    Department of Pharmacology and Institute of Natural Medicine, College of Medicine, Hallym University, Chunchon, Kangwon Do, South Korea
    Life Sci 70:2915-29. 2002
    ..suggest that proENK mRNA expression induced by repeated nicotine administrations may be mediated by AP-1 proteins, such as c-Fos, c-Jun and Fra-2 rather than CREB via interacting to the ENKCRE-2 DNA binding domain in rat adrenal medulla.
  68. ncbi TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla
    A Schober
    Department of Anatomy and Cell Biology III, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 18:7272-84. 1998
    The adrenal medulla receives its major presynaptic input from sympathetic preganglionic neurons that are located in the intermediolateral (IML) column of the thoracic spinal cord...
  69. ncbi Thyroid-adrenergic interactions: physiological and clinical implications
    J Enrique Silva
    Baystate Medical Center, Tufts University Medical School, Springfield, Massachusetts 01199, USA
    Thyroid 18:157-65. 2008
    The sympathoadrenal system, including the sympathetic nervous system and the adrenal medulla, interacts with thyroid hormone (TH) at various levels...
  70. pmc Transgenic mice express the human phenylethanolamine N-methyltransferase gene in adrenal medulla and retina
    E E Baetge
    Howard Hughes Medical Institute, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 85:3648-52. 1988
    ..These results indicate that the enhancer(s) for appropriate expression of the hPNMT gene in these cell types is in the 2-kilobase 5'-flanking region of the human gene...
  71. ncbi Tyrosine hydroxylase antisense gene therapy causes hypotensive effects in the spontaneously hypertensive rats
    T Kumai
    Department of Pharmacology, St Marianna University School of Medicine, Kawasaki shi, Japan
    J Hypertens 19:1769-73. 2001
    ..Epinephrine and norepinephrine levels, TH activity, and TH protein levels in the adrenal medulla of SHR were reduced concomitant with TH AS ODN treatment-induced changes in SBP...
  72. ncbi Identification of protein phosphatase 2A as the major tyrosine hydroxylase phosphatase in adrenal medulla and corpus striatum: evidence from the effects of okadaic acid
    J Haavik
    Department of Biochemistry, University of Bergen, Norway
    FEBS Lett 251:36-42. 1989
    ..for approximately 90% and approximately 10% of TH phosphatase activity, respectively, in extracts of adrenal medulla and corpus striatum assayed at near physiological free Mg2+ (1 mM), while type 1 and type 2B phosphatases had ..
  73. ncbi Adrenomedullin (11-26): a novel endogenous hypertensive peptide isolated from bovine adrenal medulla
    K Kitamura
    First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    Peptides 22:1713-8. 2001
    ..Using this RIA, we have characterized the molecular form of AM in bovine adrenal medulla. Gel filtration chromatography revealed that three major peaks of immunoreactive AM existed in the adrenal ..
  74. pmc Pituitary adenylate cyclase-activating polypeptide may function as a neuromodulator in guinea-pig adrenal medulla
    M Inoue
    Departments of Physiology and Anatomy, Fukuoka University School of Medicine, Fukuoka 814 0180, Japan
    J Physiol 528:473-87. 2000
    ..These observations suggest that PACAP in the guinea-pig adrenal medulla functions as a neuromodulator to facilitate ACh-induced secretion through a cAMP-protein kinase A-dependent ..
  75. pmc Sry delivery to the adrenal medulla increases blood pressure and adrenal medullary tyrosine hydroxylase of normotensive WKY rats
    Daniel Ely
    Department of Biology, University of Akron, Akron, OH 44325, USA
    BMC Cardiovasc Disord 7:6. 2007
    ..A potential candidate for this Y chromosome hypertension locus is Sry, a gene that encodes a transcription factor that is responsible for testes development and the Sry protein may affect other target genes...
  76. ncbi Quantitative evaluation of catecholamine enzymes gene expression in adrenal medulla and sympathetic Ganglia of stressed rats
    R Kvetnansky
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovak Republic
    Ann N Y Acad Sci 1018:356-69. 2004
    ..The aim of this study was to quantify basal and stress-induced levels of TH, DBH, and PNMT mRNAs in rat adrenal medulla (AM) and stellate ganglia (SG) by the RT-competitive PCR method using corresponding competitors of known ..
  77. ncbi Calcium dynamics in bovine adrenal medulla chromaffin cell secretory granules
    Jaime Santodomingo
    Departamento de Bioquimica y Biologia Molecular y Fisiologia, Facultad de Medicina, Universidad de Valladolid and Consejo Superior de Investigaciones Cientificas CSIC, Ramon y Cajal, 7, E 47005 Valladolid, Spain
    Eur J Neurosci 28:1265-74. 2008
    ..In conclusion, our data show that chromaffin cell secretory granules have the machinery required for rapid uptake and release of Ca2+, and this strongly supports the hypothesis that granular Ca2+ may contribute to its own secretion...
  78. ncbi Identification and developmental changes of aromatase and estrogen receptor expression in prepubertal and pubertal human adrenal tissues
    Maria Sonia Baquedano
    Endocrinology Service, Hospital de Pediatria Garrahan, C de los Pozos 1881, Buenos Aires, Argentina
    J Clin Endocrinol Metab 92:2215-22. 2007
    ..The mechanisms of postnatal adrenal zonation remain unclear...
  79. ncbi Role of brain thromboxane A2 in the release of noradrenaline and adrenaline from adrenal medulla in rats
    Shoshiro Okada
    Department of Pharmacology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Eur J Pharmacol 467:125-31. 2003
    Plasma noradrenaline reflects the release from adrenal medulla and sympathetic nerves; however, the exact mechanisms of adrenal noradrenaline release remain to be elucidated...
  80. pmc Active and passive membrane properties of rat sympathetic preganglionic neurones innervating the adrenal medulla
    Jennifer M M Wilson
    Neurosciences, Ottawa Health Research Institute, University of Ottawa, Ontario, Canada K1Y 4E9, UK
    J Physiol 545:945-60. 2002
    ..properties expressed by AD-SPN may be key determinants of neurotransmitter release from SPN innervating the adrenal medulla. However, factors other than active membrane conductances of AD-SPN must ultimately regulate the differential ..
  81. ncbi Diagnosis and management of tumors of the adrenal medulla
    I Ilias
    Department of Pharmacology, Medical School, University of Patras, Rion Patras, Greece 26504
    Horm Metab Res 37:717-21. 2005
    The adrenal medulla consists of chromaffin cells, the site of catecholamine biosynthesis...
  82. ncbi Immunoreactivity for cocaine- and amphetamine-regulated transcript in rat sympathetic preganglionic neurons projecting to sympathetic ganglia and the adrenal medulla
    Natalie M Fenwick
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia 5042, Australia
    J Comp Neurol 495:422-33. 2006
    ..34% projecting to the major pelvic ganglion, and about 15% projecting to the superior cervical ganglion or adrenal medulla contained CART...
  83. ncbi Stimulation of catecholamine synthesis through unique estrogen receptors in the bovine adrenomedullary plasma membrane by 17beta-estradiol
    Nobuyuki Yanagihara
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Biochem Biophys Res Commun 339:548-53. 2006
    ..These findings suggest that E(2) acutely stimulates catecholamine synthesis via activation of p44/42MAPK through unique estrogen receptors in the plasma membrane of bovine adrenal medulla.
  84. ncbi Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, mice
    A Schober
    Department of Anatomy and Cell Biology III, University of Heidelberg, Germany
    J Neurosci 17:891-903. 1997
    ..Paravertebral sympathetic neurons and chromaffin cells of the adrenal medulla share an ontogenetic origin, responsiveness to NGF, and expression of TrkA...
  85. ncbi The multifunctionality of FGF-2 in the adrenal medulla
    C Grothe
    Institute of Anatomy II, University of Freiburg, Germany
    Anat Embryol (Berl) 195:103-11. 1997
    Chromaffin cells of the adrenal medulla and their tumor counterparts, the pheochromocytoma (PC12) cells, are well-established model systems in neurobiology...
  86. ncbi Hypoxia and acidosis increase the secretion of catecholamines in the neonatal rat adrenal medulla: an in vitro study
    A J Rico
    Departamento de Bioquimica y Biologia Molecular y Fisiologia, Instituto de Biología y Genética Molecular IBGM Universidad de Valladolid, Consejo Superior de Investigaciones Cientificas, Facultad de Medicina, Calle Ramón y Cajal, 47005 Valladolid, Spain
    Am J Physiol Cell Physiol 289:C1417-25. 2005
    Hypoxia elicits catecholamine (CA) secretion from the adrenal medulla (AM) in perinatal animals by acting directly on chromaffin cells...
  87. ncbi Chronic nicotine in utero selectively suppresses hypoxic sensitivity in neonatal rat adrenal chromaffin cells
    Josef Buttigieg
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    FASEB J 22:1317-26. 2008
    ....
  88. ncbi Oxygen-sensing pathway for SK channels in the ovine adrenal medulla
    Damien J Keating
    School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 32:882-7. 2005
    ..In a heterologous expression system, SK2 and SK3 channels, the channels that initiate hypoxia-evoked changes in AMCC function, are modulated appropriately by changes in cellular redox state...
  89. ncbi Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla
    P Patak
    Department of Endocrinology, Diabetes, Rheumatology, Heinrich Heine University, Duesseldorf, Germany
    Endocr Res 30:871-5. 2004
    ..animal models and various cell culture studies confirm a crucial role for vitamin C for both the adrenal cortex as well as the adrenal medulla further underlining the interdependence of the two endocrine systems united in one gland.
  90. ncbi The adenosine analogue N6-L-phenylisopropyladenosine inhibits catecholamine secretion from bovine adrenal medulla cells by inhibiting calcium influx
    Y J Chern
    Program in Molecular and Cellular Biology, University of Massachusetts, Amherst
    J Neurochem 59:1399-404. 1992
    ..that adenine nucleotides and adenosine inhibit acetylcholine-induced catecholamine secretion from bovine adrenal medulla chromaffin cells...
  91. pmc Quantal release at a neuronal nicotinic synapse from rat adrenal gland
    J G Barbara
    Laboratoire de Pharmacologie Cellulaire et Moleculaire, Universite Louis Pasteur de Strasbourg, Illkirch, France
    Proc Natl Acad Sci U S A 93:9905-9. 1996
    The neuronal nicotinic synapse in tissue slices of the adrenal medulla was studied with whole-cell patch-clamp...
  92. ncbi Cell adhesion molecules (CAMs) in adrenal medulla in situ and in vitro: enhancement of chromaffin cell L1/Ng-CAM expression by NGF
    M Poltorak
    Preclinical Neurosciences Section, NIMH Neuroscience Center at St Elizabeths, Washington, D C 20032
    Exp Neurol 110:52-72. 1990
    ..and their common carbohydrate L2/HNK-1 epitope in normal rat adrenal gland sections as well as in adrenal medulla cell culture with and without NGF stimulation...
  93. ncbi In adrenal medulla synaptophysin (protein p38) is present in chromaffin granules and in a special vesicle population
    D Obendorf
    Department of Pharmacology, University of Innsbruck, Austria
    J Neurochem 51:1573-80. 1988
    We have analyzed the properties and subcellular localization of synaptophysin (protein p38) in bovine adrenal medulla. In one-dimensional immunoblotting the adrenal antigen appears identical to synaptophysin of rat synaptic vesicles...
  94. ncbi Noncholinergic transmitter(s) maintains secretion of catecholamines from rat adrenal medulla for several hours of continuous stimulation of splanchnic neurons
    A R Wakade
    Department of Pharmacology, State University of New York, Health Science Center at Brooklyn 11203
    J Neurochem 50:1302-8. 1988
    ..The major conclusion is that secretion of catecholamines is maintained uninterrupted for several hours when splanchnic nerves are stimulated at low frequency.(ABSTRACT TRUNCATED AT 250 WORDS)..
  95. ncbi Inhibition by pregnenolone sulfate of nicotinic acetylcholine response in adrenal chromaffin cells
    Kenzo Kudo
    Department of Pharmacology, School of Medicine, Iwate Medical University, Morioka, Japan
    Eur J Pharmacol 456:19-27. 2002
    ..Our results further indicate that pregnenolone sulfate may modulate nicotinic receptor-mediated responses in the brain...
  96. ncbi Modeling of stimulation-secretion coupling in a chromaffin cell
    A Warashina
    Division of Cell Physiology, Niigata University Graduate School of Medical and Dental Sciences, 951 8510, Niigata, Japan
    Pflugers Arch 448:161-74. 2004
    ..was also applied to simulate our experimental results obtained from chromaffin cells in the perfused rat adrenal medulla. Observed profiles of Ca(2+)responses induced by electrically stimulating the splanchnic nerve with various ..
  97. ncbi Nicotinic stimulation modulates tyrosine hydroxylase mRNA half-life and protein binding to the 3'UTR in a manner that requires transcription
    David F Roe
    Department of Neurobiology and Anatomy, The University of Texas Medical School, 5631 Fannin Street, Houston, TX 77030, USA
    Brain Res Mol Brain Res 120:91-102. 2004
    ..Thus, nicotinic stimulation produces a transcription-dependent increase in TH mRNA half-life that is mediated by previously unrecognized TH mRNA binding proteins...
  98. ncbi Influence of lobeline on catecholamine release from the isolated perfused rat adrenal gland
    Dong Yoon Lim
    Department of Pharmacology, College of Medicine, Chosun University, Gwangju 501 759, South Korea
    Auton Neurosci 110:27-35. 2004
    ..It also seems that there is a difference in the mode of action between nicotine and lobeline in rat adrenomedullary CA secretion...
  99. ncbi Effects of noradrenaline administration on the interrenal gland of the newt, Triturus carnifex: evidence of intra-adrenal paracrine interactions
    A Capaldo
    Department of Evolutive and Comparative Biology, University of Naples Federico II, 80134 Naples, Italy
    J Morphol 259:33-40. 2004
    ..The existence of intra-adrenal paracrine interactions in T. carnifex is discussed...
  100. ncbi Ceramide modulates nicotinic receptor-dependent Ca(2+) signaling in rat chromaffin cells
    J Liu
    Department of Physiology, University of Kentucky, College of Medicine, Lexington, Kentucky 40536-0298, USA
    J Neurosci Res 66:559-64. 2001
    ....
  101. ncbi Homogeneous Ca2+ stores in rat adrenal chromaffin cells
    Masumi Inoue
    Department of Physiology, Fukuoka University School of Medicine, Fukuoka 814 0180, Japan
    Cell Calcium 33:19-26. 2003
    The localization and function of Ca(2+) stores in isolated chromaffin cells of rat adrenal medulla were investigated using confocal laser microscopy and amperometry...

Research Grants62

  1. Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome
    JON DAVID LEVINE; Fiscal Year: 2013
    ..This vagotomy-induced generalized hyperalgesia depends on adrenal medulla function, a characteristic highly relevant to fibromyalgia in which chronic stress is thought to make a major ..
  2. Exocytosis and Coupled Endocytosis in Neuroendocrine Cells
    JOHN DAVID CASTLE; Fiscal Year: 2010
    ..In adrenal medulla, coupled exocytosis and endocytosis controls secretion of catecholamines, adrenalin and noradrenalin...
  3. Mechanism for Reduced Adrenomedullary Epinephrine Release in Type 1 Diabetes
    BRANLY OSVALDO ORBAN; Fiscal Year: 2012
    ..This defect has been minimally studied at the level of the adrenal medulla (AM) which produces most of all circulating epinephrine in the body...
  4. Development of the renin-expressing cell
    Maria L Sequeira Lopez; Fiscal Year: 2010
    ..e. skin, choroid plexus, sympathetic ganglia, adrenal medulla and head cartilage)...
  5. Nicotinic acetylcholine receptors and neuroblastoma
    Rae Nishi; Fiscal Year: 2012
    ..by applicant): Neuroblastoma is a cancer arising from autonomic neuron progenitor cells that occurs in the adrenal medulla or as paraspinal tumors in the abdomen or thorax of infants and young children...
  6. Interaction of RGS Protein with G beta subunit G beta 5.
    Vladlen Z Slepak; Fiscal Year: 2013
    ..The proposed study will concentrate on the analysis of catecholamine secretion by chromaffin cells of the adrenal medulla from Gbeta5 knockout mice...
  7. Integrative Consequences of Hypoxia
    Nanduri R Prabhakar; Fiscal Year: 2013
    ..tests the hypothesis that chemo reflex triggered sympathetic activation by CIH evokes oxidative stress in the adrenal medulla, a major sympathetic end organ resulfing in augmented catecholamine secretion by hypoxia, which contributes ..
  8. NTS Adenosine Receptors in Cardiovascular Control
    DONAL S O apos LEARY; Fiscal Year: 2010
    ..role of adenosine in the activation of pre-ganglionic adrenal sympathetic nerve activity which innervates the adrenal medulla. NTS adenosine receptor mediated activation of the adrenal medulla likely aids in the restoration of ..
  9. Transcription Factors in Neuroendocrine Differentiation
    Michael Lan; Fiscal Year: 2009
    ..system includes pancreatic islets, gastrointestinal and respiratory neuroendocrine cells, thyroid C cells, adrenal medulla cells, and pituitary cells. They share common phenotypes and signaling pathways with neuronal cells...
  10. MOLECULAR GENETICS OF SENSORY ORGAN DEVELOPMENT
    James W Posakony; Fiscal Year: 2013
    ..neuroblastoma (an aggressive childhood cancer), medullary thyroid cancer, pheochromocytoma (a tumor of the adrenal medulla), small cell neuroendocrine carcinoma of the prostate, and Merkel cell carcinoma of the skin...
  11. BAROREFLEX AND POSTERIOR HYPOTHALAMIC NEUROPEPTIDE-Y
    John Martin; Fiscal Year: 1991
    ..The goal of Specific Aim 2 is to determine the contribution of the adrenal medulla to the cardiovascular changes induced by NPY or CCH...
  12. Translational analysis of functional variation in human dopamine beta?hydroxylase
    Joseph F Cubells; Fiscal Year: 2012
    ..by crossing with Dbh -/- mice lacking endogenous DBH expression, to investigate DBH expression in brain, adrenal medulla and serum, associated with either the T or C allele in an otherwise identical human-sequence context of ~170 ..
  13. "Innate intestinal responses in murine toxoplasmosis"
    Fernando Monroy; Fiscal Year: 2005
    ..cortex, and release of catecholamines (epinephrine, nor-epinephrine) from sympathetic nerve terminals and the adrenal medulla. These effects are mediated through interaction with specific receptors known to be present on the surface of ..
  14. PHARMACOLOGY OF FETAL STRIATAL TISSUE TRANSPLANTS
    Andrew Norman; Fiscal Year: 1992
    ..Experiments using transplants of adult adrenal medulla and fetal tissues other than striatum will determine whether the amelioration of pharmacological deficits is ..
  15. GLYCOCONJUGATES IN SYMPATHO-ADRENAL DEVELOPMENT
    GERALD SCHWARTING; Fiscal Year: 1990
    ..Those glycocojugates which are found to be developmentally regulated, will be studied in primary cultures of adrenal medulla and sympathetic ganglia to determine their sensitivity to regulation by NGF, cyclic AMP and glucocorticoids...
  16. MECHANISMS OF TCDD TOXICITY
    Diane Russell; Fiscal Year: 1990
    ..development and function of endocrine organs such as the adrenal cortex, thyroid, pancreas and perhaps the adrenal medulla. In rats inoculated with a prolactin-secreting MtTW15 adenoma, increased serum prolactin resulted in a ..
  17. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2002
    ..stem cells differentiate into multiple tissues, including the peripheral and enteric nervous systems, the adrenal medulla, and melanocytes...
  18. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2003
    ..stem cells differentiate into multiple tissues, including the peripheral and enteric nervous systems, the adrenal medulla, and melanocytes...
  19. POMC PROCESSING & BETA-ENDORPHIN RELATED OPIOID PEPTIDE
    Vivian Hook; Fiscal Year: 2000
    ..Purified enzymes will be obtained from chromaffin granules of bovine adrenal medulla which are highly enriched in these proteases, and recombinant POMC will be expressed and purified from E...
  20. CLINICAL PET AND LABORATORY STUDIES OF ADRENERGIC TUMORS
    Barry Shulkin; Fiscal Year: 2002
    ..Epinephrine is a naturally occurring catecholamine product of the adrenal medulla and of some pheochromocytomas...
  21. ENKEPHALIN BIOSYNTHESIS IN ADRENAL MEDULLA
    Iris Lindberg; Fiscal Year: 1991
    ..We have previously carried out studies on the biosynthesis of enkephalins in the adrenal medulla. We now propose to extend and complete these studies by establishing the sequence of posttranslational ..
  22. REGULATED EXPRESSION--CATECHOLAMINE BIOSYNTHESIS GENES
    Elaine Lewis; Fiscal Year: 1991
    ..In many tissues, including the adrenal medulla, sympathetic ganglia and locus ceruleus, TH and DBH are co-expressed and coordinately regulated by induction ..
  23. DOPAMINE MONOOXYGENASE--MOLECULAR MECHANISMS
    JUDITH KLINMAN; Fiscal Year: 1999
    ..of this proposal is to elucidate the molecular mechanisms of catalysis and regulation for DbetaM from bovine adrenal medulla. A long term objective is to integrate the properties of the isolated enzyme into a detailed understanding of ..
  24. FUNCTION OF A BRAIN CALCIUM-BINDING PROTEIN
    DONALD WOLFF; Fiscal Year: 1991
    ..The endogenase substrates of the CaM-dependent phosphatase will be identified in bovine adrenal medulla and purified as thiophosphorylated analogs by affinity chromatography on the immobilized, homogeneous ..
  25. ADRENAL CATECHOLAMINE SECRETION
    ROBERT PERLMAN; Fiscal Year: 1990
    Catecholamines released from the adrenal medulla and from sympathetic nerves play an important role in the regulation of blood pressure, cardiac contractility, and heart rate...
  26. ENKEPHALIN BIOSYNTHESIS IN ADRENAL MEDULLA
    Iris Lindberg; Fiscal Year: 1992
    ..In short, the environment at L.S.U. provides an extremely favorable milieu in which to carry out the studies described in this proposal. The award of an RCDA will greatly speed the rate at which these studies are accomplished...
  27. LV DYSFUNCTION WITH MASSIVE SYMPATHETIC ACTIVITY
    CHARLES PILATI; Fiscal Year: 1993
    ..and whether the critical source of these toxic concentrations of catecholamines is the sympathetic nerves, adrenal medulla, or both...
  28. BRAIN TISSUE TRANSPLANTATION--FUNCTIONAL ACTIVITY
    Jill Becker; Fiscal Year: 1990
    ..Recently, it has been shown that grafts of fetal substantia nigra or adrenal medulla tissue placed in or near the denervated striatum can at least partially reverse these behavioral asymmetries...
  29. DEVELOPMENTAL INFLUENCES ON NEURAL CREST CELLS
    GERALD MAXWELL; Fiscal Year: 1999
    ..and glia of sympathetic, parasympathetic, enteric, and most sensory ganglia, neuroendocrine cells of the adrenal medulla and thyroid, melanocytes of the skin and irides, connective tissue cells of the head and face, and cells of ..
  30. CENTRAL CARDIOVASCULAR REGULATION--ADRENAL MEDULLA
    Shaun Morrison; Fiscal Year: 2000
    Release of catecholamines from the chromaffin cells of the adrenal medulla into the circulation plays a significant role in mediating the cardiovascular and autonomic changes that support the behavioral and physiologic responses to ..
  31. POST TRANSCRIPTIONAL REGULATION OF TH GENE
    Randy Strong; Fiscal Year: 1999
    ..e., reserpine-induce hypotension and immobilization stress. The adrenal medulla will be utilized as a model of the sympathetic system...
  32. DIET, AROMATIC AMINO ACIDS, AND CNS NEUROTRANSMITTERS
    John Fernstrom; Fiscal Year: 2001
    ..We will also study whether PHE and TYR uptake into brain and adrenal medulla, a model for peripheral CAN neurons, are similar, and whether food ingestion produces similar effects on PHE ..
  33. HOST GRAFT INTERACTIONS OF CNS CHROMAFFIN CELL IMPLANTS
    George Pappas; Fiscal Year: 1999
    ..We have obtained promising results in preliminary clinical studies using allografts of adrenal medulla to relieve cancer pain...
  34. PROTEIN PHISPHORYLATION AND NEUROSECRETION
    Michael Browning; Fiscal Year: 1990
    ..of protein III and other selected phosphoproteins (87kD, 100 kD) in subcellular fractions prepared from the adrenal medulla and from purified chromaffin cells...
  35. RECEPTOR REGULATION OF ADRENAL CATECHOLAMINE SECRETION
    DENNIS MCKAY; Fiscal Year: 1991
    The adrenal medulla is an endocrine gland which releases several hormones, the most important of which is the catecholamine, epinephrine. These hormones elicit a multitude of responses, including the classic 'fight or flight' response...
  36. ANGIOTENSIN EFFECTS IN HYPOTHALAMUS AND ADRENAL MEDULLA
    Marc Schiavone; Fiscal Year: 1993
    ..of arginine vasopressin release; 2) To characterize the interaction of angiotensin peptides with the rat adrenal medulla in the control of epinephrine release...
  37. "Toxoplasma gondii: neuro-intestinal interactions"
    Fernando Monroy; Fiscal Year: 2007
    ..Activation of the SAM system leads to release of catecholamines from sympathetic nerve terminals and from the adrenal medulla. Both glucocorticoids and catecholamines affect immune responses and exacerbate HIV disease...
  38. PATHOGENESIS OF AUTONOMIC NEUROPATHY IN TYPE I DIABETES
    STEVEN RABINOWE; Fiscal Year: 1992
    ..Recent studies in my laboratory have demonstrated complement fixing autoantibodies directed against adrenal medulla, sympathetic ganglia, and vagus nerve in pre-type I diabetes and patients with clinically overt Type I ..
  39. NPY AND THE PLATELET-VASCULAR INTERACTION
    Adam Myers; Fiscal Year: 1992
    ..nerves innervating the cardiovascular system, and catecholamine-containing chromaffin cells of the adrenal medulla. It is co-released with norepinephrine (NE) during sympathetic nerve stimulation and during prolonged and ..
  40. LOCALIZATION OF ADRENERGIC AND NPY RECEPTORS IN HEART
    KATHRYN MUNTZ; Fiscal Year: 1993
    ..system releases norepinephrine and neuropeptide Y locally from nerve terminals, and epinephrine from the adrenal medulla, transmitters which can bind to specific receptors localized in the heart...
  41. ANION EXCHANGE AND OSMOTIC BALANCE OF SECRETORY VESICLES
    David Njus; Fiscal Year: 1990
    ..Cl-/HC03- exchange characterized using bovine chromaffin vesicles, the catecholamine storage vesicles of the adrenal medulla. Specific objectives are 1) to develop assays for anion exchange activity and characterize inhibitors, 2) to ..
  42. PRIMATE ENDOCRINE REGULATION IN THE PERINATAL PERIOD
    Robert Jaffe; Fiscal Year: 1992
    ..Further, the ontogeny and regulation of catecholamines and enkephalins in the fetal adrenal medulla, will be studied...
  43. SOMATOSYMPATHETIC REFLEXES--NEUROATOMICAL SUBSTRATES
    DAVID RUGGIERO; Fiscal Year: 1992
    ..phrenic motor neurons, as identified neurochemically or by retrograde transport from sympathetic ganglia or adrenal medulla and phrenic nerve...
  44. MATERNAL-FETAL PHARMACOLOGY OF THE DRUGS OF ABUSE
    Hazel Szeto; Fiscal Year: 1993
    ..morphine in the fetus may be due to a lower proportion of enkephalin peptides to catecholamines in the fetal adrenal medulla. The testing of these hypotheses would require different techniques that are currently not available in my ..
  45. ADRENAL NICOTINIC RECEPTORS AND CATECHOLAMINE SECRETION
    DENNIS MCKAY; Fiscal Year: 2001
    ..Chromaffin cells from the adrenal medulla express neuronal nAChRs...
  46. MECHANISMS OF STRESS SPECIFIC CHANGES IN GENE EXPRESSION
    Esther Sabban; Fiscal Year: 2000
    ..of regulation of gene expression of catecholamine biosynthetic enzymes (TH, DBH, and PNMT) in vivo in the adrenal medulla, sympathetic ganglia, and in different brain areas of rats exposed acutely, repeatedly or chronically to ..
  47. ANTIARRHYTHMIC STUDIES ON 2-SUBSTITUTED AMINOINDENES
    RALF RAHWAN; Fiscal Year: 1980
    ..coupling in a variety of smooth muscle preparations and stimulus-secretion coupling in the isolated adrenal medulla. Additional studies demonstrated that the 2-substituted aminoindenes relaxed isolated bovine coronary vessel ..
  48. CHROMOGRANIN A IN EXPERIMENTAL HYPERTENSION
    MARWAN TAKIYYUDDIN; Fiscal Year: 1993
    Chromogranin A (CgA) is the major soluble protein stored in catecholamine storage vesicles in the adrenal medulla and sympathetic nerves. Its plasma concentration varies as a function of sympathoadrenal activation...
  49. DBH as a Modifying Gene in Neurodegenerative Diseases
    Cyrus Zabetian; Fiscal Year: 2006
    ..Levels of DBH protein and mRNA will be compared in postmortem human adrenal medulla specimens, homozygous for either the C or T allele, using western blots and quantitative real time RT-PCR, ..
  50. REGULATION OF NEURONAL GROWTH AND DEVELOPMENT
    IRA BLACK; Fiscal Year: 1992
    ..neurohumoral systems within the same cell, using cDNA to proenkephalin and tyrosine hydroxylase in the adrenal medulla; f) determine how neuronal aggregation alters transmitter phenotypic expression; g) define mechanisms by ..
  51. Sympathetic Ganglia: New Target for ACTH with Stress
    Esther Sabban; Fiscal Year: 2008
    ..abstract_text> ..
  52. MOLECULAR BIOLOGY OF NOREPINEPHRINE BIOSYNTHESIS
    Esther Sabban; Fiscal Year: 2006
    ..of pathways involved in transcriptional activation of TH and DBH gene expression in locus coeruleus and adrenal medulla with different durations or repetitions of stress. 3...
  53. ENVIRONMENTAL TEMPERATURE, SNS DEVELOPMENT AND OBESITY
    James Young; Fiscal Year: 2005
    ..The potential impact of changes in sympathetic activity regulated by RPa for glucose and energy metabolism will also be examined. ..
  54. EPIDERMAL GROWTH FACTOR, OBESITY & INSULIN RESISTANCE
    James Young; Fiscal Year: 2001
    ..A principal tenet of this proposal is that early life events which predispose animals to become obese differ from those which promote subsequent development in insulin resistance. ..
  55. Effects of Maternal Diet on SNS Development in Offspring
    James Young; Fiscal Year: 2009
    ..Identifying connections among growth, SNS development and obesity offers a potential means for identifying obesity-prone individuals early in life with the ultimate objective of intervening in an effective and appropriate manner. ..
  56. PHEOCHROMOCYTOMAS FROM NEUROFIBROMATOSIS KNOCKOUT MICE
    Arthur Tischler; Fiscal Year: 2003
    Endocrine tumors of the adrenal medulla are known as pheochromocytomas. These tumors are rare in humans, as in most other species, except in patients with hereditary endocrine or neurocutaneous tumor syndromes...
  57. Proteomics/Genomics of Opiate Analgesia and Addiction
    Vivian Hook; Fiscal Year: 2004
    ..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
  58. Sympathetic Outflow to Catecholamine Storage Vesicles
    DANIEL O CONNOR; Fiscal Year: 2006
    ..Finally, these photoprotein and cDNA reagents can be widely employed by other investigators in elucidating biosynthetic, trafficking, and ion flux events in the sympathochromaffin system. ..
  59. CHROMAFFIN CELL PROLIFERATION IN NEOPLASTIC PROGRESSION
    Arthur Tischler; Fiscal Year: 2006
    ..The proposed studies will help to elucidate mechanisms that may be involved in the development and progression of pheochromocytomas. ..
  60. Estrogen and sodium modulate hypertension in aging rats
    Carmen Hinojosa Laborde; Fiscal Year: 2006
    ..Importantly, a greater understanding will be obtained addressing why the protection disappears with the aging process. ..
  61. INTEGRATED DNA SEQUENCING SYSTEM
    Vivian Hook; Fiscal Year: 2002
    ..abstract_text> ..
  62. Consequences of Neonatal Hypoxia
    Nanduri Prabhakar; Fiscal Year: 2009
    ..Understanding the consequences of neonatal IH provide insights into how neonatal intermittent hypoxia caused by recurrent apneas affects the ventilation in premature infants. Experimental Animal Model: Rat Pups. ..