endocrine system

Summary

Summary: The system of glands that release their secretions (hormones) directly into the circulatory system. In addition to the ENDOCRINE GLANDS, included are the CHROMAFFIN SYSTEM and the NEUROSECRETORY SYSTEMS.

Top Publications

  1. ncbi Endocrine alteration in juvenile cod and turbot exposed to dispersed crude oil and alkylphenols
    Rebeca Martin-Skilton
    Environmental Chemistry Department IIQAB CSIC, c Jordi Girona, 18, 08034 Barcelona, Spain
    Aquat Toxicol 78:S57-64. 2006
  2. ncbi Vitamin D endocrine system involvement in autoimmune rheumatic diseases
    Maurizio Cutolo
    Research Laboratories and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Italy
    Autoimmun Rev 11:84-7. 2011
  3. ncbi The endocrine system and ageing
    H S Chahal
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    J Pathol 211:173-80. 2007
  4. ncbi Selenium, the thyroid, and the endocrine system
    J Kohrle
    Institut für Experimentelle Endokrinologie, Charite, Humboldt Universitat zu Berlin, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Endocr Rev 26:944-84. 2005
  5. ncbi Cutaneous photosynthesis of vitamin D: an evolutionary highly-conserved endocrine system that protects against environmental hazards including UV-radiation and microbial infections
    Lea Tremezaygues
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Anticancer Res 26:2743-8. 2006
  6. ncbi Novel interactions of adiponectin with the endocrine system and inflammatory parameters
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, Department of Internal Medicine, University Hospital of Girona Dr Josep Trueta, 17007 Girona, Spain
    J Clin Endocrinol Metab 88:2714-8. 2003
  7. ncbi Supplements and the endocrine system in athletes
    Luigi Di Luigi
    Unit of Endocrinology, Department of Health Sciences, University Institute of Movement Sciences, Piazza Lauro de Bosis 15, 00194 Rome, Italy
    Clin Sports Med 27:131-51, ix. 2008
  8. ncbi The endocrine system in diabetes mellitus
    Hisham Alrefai
    Division of Endocrinology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Endocrine 18:105-19. 2002
  9. ncbi The impact of opioids on the endocrine system
    Nathaniel Katz
    Analgesic Research, Tufts University School of Medicine, Boston, MA, USA
    Clin J Pain 25:170-5. 2009
  10. ncbi Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    Guoqiang Gu
    Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 129:2447-57. 2002

Research Grants

  1. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
  2. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
  3. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK KUMAR SARKAR; Fiscal Year: 2013
  4. Molecular Physiology of the Epitrachael Endocrine System
    Michael E Adams; Fiscal Year: 2012
  5. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK SARKAR; Fiscal Year: 2009
  6. Adipocyte Renin-Angiotensin System and Programming of Hypertension
    Mina Desai; Fiscal Year: 2010
  7. Vitamin D and the Immune System
    Lawrence Steinman; Fiscal Year: 2012
  8. Interplay between the Endocrine and Innate Systems of Drosphila
    Neal Silverman; Fiscal Year: 2013
  9. Intragenic Suppressors of McCune-Albright Syndrome Mutations
    ROBIN PALS RYLAARSDAM; Fiscal Year: 2010
  10. Bisphenol-A and Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2013

Detail Information

Publications262 found, 100 shown here

  1. ncbi Endocrine alteration in juvenile cod and turbot exposed to dispersed crude oil and alkylphenols
    Rebeca Martin-Skilton
    Environmental Chemistry Department IIQAB CSIC, c Jordi Girona, 18, 08034 Barcelona, Spain
    Aquat Toxicol 78:S57-64. 2006
    ..In fact, apart from a higher glucuronidation rate of estradiol detected in the liver of NP-exposed cod, no significant differences were observed between control and exposed cod...
  2. ncbi Vitamin D endocrine system involvement in autoimmune rheumatic diseases
    Maurizio Cutolo
    Research Laboratories and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Italy
    Autoimmun Rev 11:84-7. 2011
    ..Recently, the onset of symptoms of early arthritis during winter or spring have been associated with greater radiographic evidence of disease progression at 12 months possibly are also related to seasonal lower vitamin D serum levels...
  3. ncbi The endocrine system and ageing
    H S Chahal
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    J Pathol 211:173-80. 2007
    Complex changes occur within the endocrine system of ageing individuals. This article explores the changes that occur in the metabolism and production of various hormones and discusses the resulting clinical consequences...
  4. ncbi Selenium, the thyroid, and the endocrine system
    J Kohrle
    Institut für Experimentelle Endokrinologie, Charite, Humboldt Universitat zu Berlin, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Endocr Rev 26:944-84. 2005
    ..Comparative analysis of the genomes of several life forms reveals that higher mammals contain a limited number of identical genes encoding newly detected selenocysteine-containing proteins...
  5. ncbi Cutaneous photosynthesis of vitamin D: an evolutionary highly-conserved endocrine system that protects against environmental hazards including UV-radiation and microbial infections
    Lea Tremezaygues
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Anticancer Res 26:2743-8. 2006
    ..D, that has recently emerged, is summarized: the role of vitamin D as an evolutionary highly-conserved endocrine system that protects the skin and other tissues against environmental hazards, including ionizing and UV-radiation, ..
  6. ncbi Novel interactions of adiponectin with the endocrine system and inflammatory parameters
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, Department of Internal Medicine, University Hospital of Girona Dr Josep Trueta, 17007 Girona, Spain
    J Clin Endocrinol Metab 88:2714-8. 2003
    ....
  7. ncbi Supplements and the endocrine system in athletes
    Luigi Di Luigi
    Unit of Endocrinology, Department of Health Sciences, University Institute of Movement Sciences, Piazza Lauro de Bosis 15, 00194 Rome, Italy
    Clin Sports Med 27:131-51, ix. 2008
    ..Very often, the effects of many supplements are hormone-related, or supplements influence hormone secretion. Examples of possible links between "supplements or ergogenic compounds" and the endocrine/metabolic system are addressed...
  8. ncbi The endocrine system in diabetes mellitus
    Hisham Alrefai
    Division of Endocrinology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Endocrine 18:105-19. 2002
    ..Cumulative evidence also reveals that the endocrine system is not intact in patients with diabetes mellitus...
  9. ncbi The impact of opioids on the endocrine system
    Nathaniel Katz
    Analgesic Research, Tufts University School of Medicine, Boston, MA, USA
    Clin J Pain 25:170-5. 2009
    ..However, their negative effects on the endocrine system, which have been known for some times, are barely discussed in modern medicine...
  10. ncbi Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    Guoqiang Gu
    Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 129:2447-57. 2002
    ..5 (E9.5-E11.5). These findings suggest that lineages for exocrine, endocrine islet and duct progenitors are committed at mid-gestation...
  11. ncbi Piecing together evolution of the vertebrate endocrine system
    Robert K Campbell
    Serono Reproductive Biology Institute, One Technology Place, Rockland, MA 02370, USA
    Trends Genet 20:359-66. 2004
    ..In this article, we address the origin of the vertebrate hypothalamic-pituitary-peripheral gland (H-P-PG) endocrine system, a complex network of specialized tissues, ligands and receptors...
  12. ncbi Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types
    Kerstin A Johansson
    Swiss Institute for Experimental Cancer Research, 155 ch des Boveresses, 1066 Epalinges, Switzerland
    Dev Cell 12:457-65. 2007
    ..We further show that the progenitors acquire competence to generate late-born cells in a mechanism that is intrinsic to the epithelium...
  13. ncbi Occurrence and fate of hormone steroids in the environment
    Guang Guo Yin
    CSIRO Land and Water, Adelaide Laboratory, PMB 2, Glen Osmond, SA 5064, Australia
    Environ Int 28:545-51. 2002
    ..Consequently, the exposure and risk associated with these chemicals are not adequately understood...
  14. pmc Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: what do we really know?
    James M Rippe
    University of Central Florida Medical School, Orlando, FL and Rippe Lifestyle Institute, Shrewsbury, MA, USA
    Adv Nutr 4:236-45. 2013
    ..The purpose of this review is to summarize current knowledge about the metabolism, endocrine responses, and potential health effects of sucrose, HFCS, and fructose...
  15. ncbi Reproductive, endocrine and metabolic feto-maternal features and placental gene expression in a swine breed with obesity/leptin resistance
    A Gonzalez-Bulnes
    Departamento de Reproduccion Animal, Instituto Nacional de Investigaciones Agrarias, 28040 Madrid, Spain
    Gen Comp Endocrinol 176:94-101. 2012
    ..In conclusion, the conceptus viability and growth appear to be strongly related to maternal metabolic features and, thus, affected in females with alterations in lipid metabolism...
  16. ncbi The diffuse endocrine system: from embryogenesis to carcinogenesis
    Luis M Montuenga
    Department of Histology and Pathology, Schools of Science and Medicine, University of Navarra, 31080 Pamplona, Spain
    Prog Histochem Cytochem 38:155-272. 2003
    In the present review we will summarise the current knowledge about the cells comprising the Diffuse Endocrine System (DES) in mammalian organs...
  17. ncbi Acute and cumulative effects of focused high-frequency vibrations on the endocrine system and muscle strength
    Pierpaolo Iodice
    Department of Basic and Applied Medical Sciences, G D Annunzio University, Chieti, Italy
    Eur J Appl Physiol 111:897-904. 2011
    ..Our results indicate that HLV influences the levels of particular hormones and improves neuromuscular performance. Our results indicate that HLV has a long-term beneficial effect comparable to that of resistance training...
  18. ncbi Role of the vitamin D-endocrine system in the pathophysiology of postmenopausal osteoporosis
    B Lawrence Riggs
    Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Cell Biochem 88:209-15. 2003
    ..The calcium absorption defects are associated with several abnormalities of the vitamin D-endocrine system including secondary hyperparathyroidism, intestinal resistance to 1,25-dihydroxyvitamin D (1,25(OH)(2)D) ..
  19. pmc The OECD program to validate the rat uterotrophic bioassay: an overview
    William Owens
    Central Product Safety, The Procter and Gamble Company, 11810 East Miami River Road, Cincinnati, OH 45252, USA
    Environ Health Perspect 111:1527-9. 2003
    ..g., animal strain, diet, housing, bedding, vehicle, animal age). In conclusion, all protocols now have sufficient data to support their validity...
  20. ncbi Evolution of the reproductive endocrine system in chordates
    Kaoru Kubokawa
    Misaki Marine Biological Station, University of Tokyo, Koajiro, Miura 238 0225, Japan
    Integr Comp Biol 50:53-62. 2010
    ..Despite many studies on the endocrine system of amphioxus, definitive evidence has not been reported for the presence an endocrine system comparable to ..
  21. ncbi Transgenerational and developmental exposure of Japanese medaka (Oryzias latipes) to ethinylestradiol results in endocrine and reproductive differences in the response to ethinylestradiol as adults
    Christy M Foran
    Environmental Toxicology Research Program and Department of Pharmacology, The University of Mississippi, University, Mississippi 38677, USA
    Toxicol Sci 68:389-402. 2002
    ..Our results indicate that the relationship between biomarkers and estrogen exposure will be altered by the timing and frequency of exposure...
  22. ncbi Chronic use of opioids and the endocrine system
    Z Merza
    Diabetes and Endocrinology Centre, Barnsley Foundation Hospital, Barnsley, UK
    Horm Metab Res 42:621-6. 2010
    ..They are also abused for recreational purposes. Long term use may lead to abnormalities in the endocrine system. The axis mainly affected is the gonadal axis leading to hypogonadism...
  23. ncbi Diffuse endocrine system, neuroendocrine tumors and immunity: what's new?
    Pietro Ameri
    Department of Internal Medicine and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
    Neuroendocrinology 95:267-76. 2012
    ....
  24. ncbi A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system
    Matthias Zielonka
    Max Planck Institute for Heart and Lung Research, Department of Pharmacology, Ludwigstr 43, 61231 Bad Nauheim, Germany
    Exp Cell Res 316:2477-86. 2010
    ..This work establishes Plexin-B2 and Sema4C as potential regulators of the vascular and endocrine system and provides an anatomical basis to understand the biological functions of this ligand-receptor pair.
  25. ncbi Electromagnetic fields and human endocrine system
    Michal Karasek
    Department of Electron Microscopy, Chair of Pathomorphology, Medical University of Lodz, Poland
    ScientificWorldJournal 4:23-8. 2004
    ..studies indicate that EMF may influence secretion of some hormones, the data on the effects of EMF on human endocrine system are scarce. Most of the results concentrate on influence of EMF on secretion of melatonin...
  26. ncbi Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. A review of evidence
    A F Reis
    Inserm Unité 695, Faculte de Medecine Xavier Bichat, 16, rue Henri Huchard, 75018 Paris, France
    Diabetes Metab 31:318-25. 2005
    The Vitamin D endocrine system regulates multiple aspects of calcium metabolism and cellular differentiation and replication in the immune system, endocrine pancreas, liver, skeletal muscles and adipocytes...
  27. ncbi Environmental exposures that affect the endocrine system: public health implications
    C Derosa
    Division of Toxicology, Agency for Toxic Substances and Disease Registry, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
    J Toxicol Environ Health B Crit Rev 1:3-26. 1998
    ....
  28. ncbi New disorders in carbohydrate metabolism: congenital disorders of glycosylation and their impact on the endocrine system
    Bradley S Miller
    Division of Pediatric Endocrinology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    Rev Endocr Metab Disord 4:103-13. 2003
  29. ncbi The hidden life of NAD+-consuming ectoenzymes in the endocrine system
    Fabio Malavasi
    Laboratory of Immunogenetics and CeRMS, Department of Genetics, Biology and Biochemistry, University of Torino School of Medicine, Turin, Italy
    J Mol Endocrinol 45:183-91. 2010
    ..Almost two decades of accumulated data indicate that these regulatory processes significantly affect the endocrine system, a tightly controlled information signal complex with clear evidence of fine regulation...
  30. ncbi [Role of the endocrine system in the pathogenesis of non-alcoholic fatty liver disease]
    Krisztina Hagymasi
    Belgyógyászati Klinika Budapest, Budapest
    Orv Hetil 150:2173-81. 2009
    ..pathogenesis is a complex, multifactorial process, characterized by insulin resistance and involvement of the endocrine system. Hypothyroidism may lead to nonalcoholic steatohepatitis via hyperlipidemia and obesity...
  31. ncbi Ex vivo analysis of acinar and endocrine cell development in the human embryonic pancreas
    Muriel Castaing
    Universite Paris Descartes, Faculté de Médecine INSERM, France
    Dev Dyn 234:339-45. 2005
    ..This proliferative capacity of early endocrine progenitor cells in embryonic human pancreas may hold promise for obtaining human beta-cell expansion...
  32. ncbi Effects of the pesticides carbofuran, chlorpyrifos, dimethoate, lindane, triallate, trifluralin, 2,4-D, and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes
    N C Rawlings
    Department of Veterinary Physiological Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
    J Toxicol Environ Health A 54:21-36. 1998
    ..Data suggest that several currently used pesticides could influence serum concentrations of reproductive and metabolic hormones, particularly thyroxine, the major secretory product of the thyroid and a principal regulator of metabolism...
  33. ncbi Evaluation of vitamin D endocrine system (VDES) status and response to treatment of patients in intensive care units (ICUs) using an on-line SPE-LC-MS/MS method
    J M Mata-Granados
    Department of I D i, Sanyres Group, University of Cordoba, Mineral Metabolism Unit, Hospital Reina Sofia, E 14004 Cordoba, Spain
    J Steroid Biochem Mol Biol 121:452-5. 2010
    ..The aim of the study here presented was to evaluate the vitamin D endocrine system (VDES) status in healthy blood donors and critically ill patients baseline and in response to treatment ..
  34. pmc The hormonal action of IGF1 in postnatal mouse growth
    Elias Stratikopoulos
    Department of Genetics and Development, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:19378-83. 2008
    ....
  35. ncbi Negative impact of endocrine-disrupting compounds on human reproductive health
    Damjan Balabanič
    Pulp and Paper Institute, Bogišićeva ulica 8, SI 1000 Ljubljana, Slovenia
    Reprod Fertil Dev 23:403-16. 2011
    ..Although EDCs may be released into the environment in different ways, the main sources is industrial waste water. The present paper critically reviews the current knowledge of the impact of EDCs on reproductive disorders in humans...
  36. ncbi The immunological functions of the vitamin D endocrine system
    C E Hayes
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Cell Mol Biol (Noisy-le-grand) 49:277-300. 2003
    ..and that immune system cells express the vitamin D receptor (VDR), suggested that the vitamin D endocrine system influences immune system function...
  37. ncbi Role of pituitary adenylate cyclase-activating polypeptide in the pancreatic endocrine system
    Bo Ahren
    Department of Clinical Sciences, Division of Medicine, Lund University, Lund, Sweden
    Ann N Y Acad Sci 1144:28-35. 2008
    ..Hence, PACAP is an islet neuropeptide with a potential role in islet physiology and as a basis for development of islet-promoting therapy in type 2 diabetes...
  38. ncbi Physiological roles of the leptin endocrine system: differences between mice and humans
    J Himms-Hagen
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, ON
    Crit Rev Clin Lab Sci 36:575-655. 1999
    ..This review concentrates on roles of leptin in human physiology and pathophysiology but also discusses why some observations on actions of leptin in mice are not applicable to humans...
  39. ncbi Sunlight, the vitamin D endocrine system, and their relationships with gynaecologic cancer
    Faustino R Pérez-López
    Department of Obstetrics and Gynaecology, University of Zaragoza Faculty of Medicine, Domingo Miral s n, Zaragoza 50009, Spain
    Maturitas 59:101-13. 2008
    ....
  40. ncbi Impaired immune responses in tuberculosis patients are related to weight loss that coexists with an immunoendocrine imbalance
    Carolina Mahuad
    Instituto de Inmunologia, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Rosario, Argentina
    Neuroimmunomodulation 14:193-9. 2007
    ..To conclude, the relation between weight loss and abnormal immune response of TB patients is partly associated with the immunoendocrine imbalance observed in parallel...
  41. ncbi Evidence of effects of environmental chemicals on the endocrine system in children
    Walter J Rogan
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Pediatrics 112:247-52. 2003
    ..Although endocrine disruption in humans by pollutant chemicals remains largely undemonstrated, the underlying science is sound and the potential for such effects is real...
  42. ncbi Characterization of the vitamin D endocrine system in human sebocytes in vitro
    Christina Krämer
    Department of Dermatology, The Saarland University Hospital, 66421 Homburg Saar, Germany
    J Steroid Biochem Mol Biol 113:9-16. 2009
    ..Our findings indicate that the vitamin D endocrine system is of high importance for sebocyte function and physiology...
  43. pmc Conserved genetic pathways controlling the development of the diffuse endocrine system in vertebrates and Drosophila
    Volker Hartenstein
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Gen Comp Endocrinol 166:462-9. 2010
    ..In this review we compare the development of the intestinal endocrine cells in vertebrates and insects and summarize recent findings dealing with genetic pathways controlling this cell type...
  44. ncbi Dysfunction of the vitamin D endocrine system as common cause for multiple malignant and other chronic diseases
    Meinrad Peterlik
    Department of Pathophysiology, Medical University Vienna, A 1090 Vienna, Austria
    Anticancer Res 26:2581-8. 2006
    ....
  45. ncbi Comparative effects of butyl benzyl phthalate (BBP) and di(2-ethylhexyl) phthalate (DEHP) on the aquatic larvae of Chironomus riparius based on gene expression assays related to the endocrine system, the stress response and ribosomes
    Rosario Planelló
    Grupo de Biología y Toxicología Ambiental, Facultad de Ciencias, Universidad Nacional de Educacion a Distancia, UNED, Senda del Rey 9, 28040 Madrid, Spain
    Aquat Toxicol 105:62-70. 2011
    ..of the alterations in gene expression profiles of selected inducible and constitutive genes related to the endocrine system, the cellular stress response and the ribosomal machinery...
  46. ncbi In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg Germany
    Cancer Biol Ther 6:48-55. 2007
    ..In conclusion, we characterize the vitamin D endocrine system in melanoma cells and demonstrate that the majority of melanoma cell lines analyzed is resistant to ..
  47. pmc The OECD program to validate the rat uterotrophic bioassay. Phase 2: dietary phytoestrogen analyses
    William Owens
    Human and Environmental Safety, The Procter and Gamble Company, 11810 East Miami River Road, Cincinnati, OH 45252, USA
    Environ Health Perspect 111:1559-67. 2003
    ....
  48. ncbi Physiological and pathological angiogenesis in the endocrine system
    Miklos I Goth
    Department of Medicine, National Medical Center, H 1135 Budapest, Hungary
    Microsc Res Tech 60:98-106. 2003
    ..Experimental and clinical aspects of interactions between angiogenic factors and tumor growth of the endocrine system are also discussed.
  49. ncbi All-trans retinoic acid induces differentiation of ducts and endocrine cells by mesenchymal/epithelial interactions in embryonic pancreas
    Sidhartha Singh Tulachan
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Diabetes 52:76-84. 2003
    ....
  50. ncbi The adrenal cortex and steroidogenesis as cellular and molecular targets for toxicity: critical omissions from regulatory endocrine disrupter screening strategies for human health?
    Philip W Harvey
    Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire HG3 1PY, UK
    J Appl Toxicol 23:81-7. 2003
    ..Adequate assessment of adrenocortical function, as with any component of the integrated endocrine system, probably also will require the development of specific in vivo methodology to include effects on hypothalamo-..
  51. ncbi Endocrine-disrupting chemicals use distinct mechanisms of action to modulate endocrine system function
    Derek V Henley
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 147:S25-32. 2006
    ..diverse class of synthetic and natural compounds that possess the ability to alter various components of the endocrine system and potentially induce adverse health effects in exposed individuals and populations...
  52. ncbi Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1
    Philippe Bertolino
    Laboratory of Genetics, Centre National de la Recherche Scientifique, Faculty of Medicine, University of Lyon, Lyon, France
    Mol Endocrinol 17:1880-92. 2003
    ..All of these features are reminiscent of MEN1 symptoms in humans and establish heterozygous Men1 mutant mice as a suitable model for this disease...
  53. pmc High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women
    Myrto Petreas
    Hazardous Materials Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley 94704, USA
    Environ Health Perspect 111:1175-9. 2003
    ..Rising body burdens of endocrine-disrupting chemicals such as PBDEs may pose a potential public health threat...
  54. pmc Enhanced degradation of an endocrine-disrupting chemical, butyl benzyl phthalate, by Fusarium oxysporum f. sp. pisi cutinase
    Yang Hoon Kim
    Department of Chemical and Biological Engineering, Korea University, Sungbuk Ku, Seoul 136 701
    Appl Environ Microbiol 68:4684-8. 2002
    ..Toxicity monitoring using bioluminescent bacteria showed that butyl methyl phthalate, a major product of degradation by esterase, was an oxidative toxic hazard...
  55. ncbi The role of the endocrine system in baboon maternal behavior
    Massimo Bardi
    Department of Comparative Medicine, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Biol Psychiatry 55:724-32. 2004
    ....
  56. ncbi The Vitamin D endocrine system of the gut--its possible role in colorectal cancer prevention
    Heide S Cross
    Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, A 1090 Vienna, Waehringer Guertel 18 20, Austria
    J Steroid Biochem Mol Biol 97:121-8. 2005
    ..These results and our observation that 17beta-estradiol can elevate CYP27B1 expression in rectal tissue of postmenopausal women, may underlie the observed protective effect of estrogens against colorectal cancer in females...
  57. ncbi The endocrine system during sepsis
    Stephen Brierre
    Section of Pulmonary Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Med Sci 328:238-47. 2004
    ..Whether the euthyroid sick syndrome represents an adaptive or a maladaptive response to severe illness remains unclear...
  58. ncbi Chronobiology in the endocrine system
    Erhard Haus
    Department of Laboratory Medicine and Pathology, University of Minnesota, Health Partners Medical Group, Regions Hospital, 640 Jackson Street, St Paul, Minnesota 55101, USA
    Adv Drug Deliv Rev 59:985-1014. 2007
    ..In the design of drug-delivery systems and treatment schedules involving directly or indirectly the endocrine system, consideration of the human time organization is essential...
  59. ncbi Proteomics in zebrafish exposed to endocrine disrupting chemicals
    E A Shrader
    University of Maryland UMBC, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Ecotoxicology 12:485-8. 2003
    ..1 ppm. While there are many proteins that respond specifically to each chemical, relatively few are common to the two chemicals suggesting that the response pathways of the two chemicals are distinct...
  60. ncbi Pesticide use in the U.S. and policy implications: a focus on herbicides
    P Short
    Wildlife and Contaminants Program, World Wildlife Fund, Washington, District of Columbia 20037, USA
    Toxicol Ind Health 15:240-75. 1999
    ..A thorough assessment of potential exposure to herbicides by wildlife and humans is limited due to the inaccessibility of production and usage data...
  61. ncbi An integrated "4-phase" approach for setting endocrine disruption screening priorities--phase I and II predictions of estrogen receptor binding affinity
    L Shi
    R O W Sciences, Inc, Jefferson, AR 72079, USA
    SAR QSAR Environ Res 13:69-88. 2002
    ..We believe that the same integrated scheme will be equally applicable to endpoints of other endocrine disrupting mechanisms, e.g. androgen receptor binding...
  62. ncbi Endocrine measures of stress and self-rated health: a longitudinal study
    Christina Halford
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    J Psychosom Res 55:317-20. 2003
    ..Studies including biological data are, however, few. The purpose of this paper is to study the relationship between endocrine measures of stress and SRH...
  63. ncbi Cellular and molecular responses to endocrine-modulators and the impact on fish reproduction
    A Arukwe
    Department of Molecular Biology, University of Bergen, Norway
    Mar Pollut Bull 42:643-55. 2001
    ..In this context, we ought to be concerned with the health and safety of aquatic species per se, as well as a resource for human needs...
  64. ncbi Juvenile sea bass biotransformation, genotoxic and endocrine responses to beta-naphthoflavone, 4-nonylphenol and 17 beta-estradiol individual and combined exposures
    M Teles
    Department of Biology, Aveiro University, Campus de Santiago, 3810 193 Aveiro, Portugal
    Chemosphere 57:147-58. 2004
    ..Fish responses to mixtures of xenobiotics are complex and the type of interaction (synergism/potentiation or antagonism) in a particular mixture can vary with the evaluated biological response...
  65. pmc Prediction of estrogen receptor binding for 58,000 chemicals using an integrated system of a tree-based model with structural alerts
    Huixiao Hong
    R O W Sciences, Inc, Jefferson, Arkansas 72079, USA
    Environ Health Perspect 110:29-36. 2002
    ..The general approach for predicting ER binding reported here may be applied to other receptors and/or reversible binding mechanisms involved in endocrine disruption...
  66. ncbi The nationwide investigation of endocrine disruptors in sediment of harbours
    Yasushi Hosokawa
    Ministry of Land, Interstructure and Transport, 3 1 1 Nagase, 239 0826, Yokosuka, Japan
    Mar Pollut Bull 47:132-8. 2003
    ..This result coincides with the facts that, during roughly 1960-1980, PCP and CNP were used as agricultural chemicals and full-scale production of PCBs started in 1960...
  67. pmc Clustering of sex hormone disruptors in Singapore's marine environment
    Yinhan Gong
    Tropical Marine Science Institute, National University of Singapore, Republic of Singapore
    Environ Health Perspect 111:1448-53. 2003
    ....
  68. ncbi Deviations in the endocrine system and brain of patients with fibromyalgia: cause or consequence of pain and associated features?
    Rinie Geenen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 1193:98-110. 2010
    The brain and endocrine system are crucial interfaces responding to pathological and psychological processes...
  69. ncbi In vitro biomonitoring in polar extracts of solid phase matrices reveals the presence of unknown compounds with estrogenic activity
    J Legler
    Toxicology Section, Wageningen University, 6700 EA Wageningen, The Netherlands
    Ecotoxicology 12:239-49. 2003
    ..The EEQ activity of the unknown compounds in the polar fraction mostly was much higher than the calculated EEQ levels based on known estrogens in the non-polar fraction (previously published data)...
  70. ncbi Assessment of total effective xenoestrogen burden in adipose tissue and identification of chemicals responsible for the combined estrogenic effect
    Mariana F Fernandez
    Laboratory of Medical Investigations, Hospital Clinico, University of Granada, 18071 Granada, Spain
    Anal Bioanal Chem 379:163-70. 2004
    ....
  71. ncbi Xenoestrogen modulation of the immune system: effects of dichlorodiphenyltrichloroethane (DDT) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    Hanan A Forawi
    Molecular Toxicology Research Laboratory, NIH Center for Environmental Health, School of Science and Technology, Jackson State University, Jackson, Mississippi 39217, USA
    Rev Environ Health 19:1-13. 2004
    ..Both compounds have substantial immune system and endocrine system disrupting activity, acting as estrogen agonists or antagonists (xenoestrogens)...
  72. ncbi Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: report from the European IDEA project
    H Segner
    Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, Permoserstrasse 15, D 04318 Leipzig, Germany
    Ecotoxicol Environ Saf 54:302-14. 2003
    ..the estrogen-induced alterations in the invertebrate species indeed do result from disturbances of the endocrine system. The findings of the present research project support the development of appropriate testing methodologies ..
  73. ncbi Development of on-site fish exposure system placed in water quality monitoring stations along a river
    T Higashitani
    Water Quality Research Team, Public Works Research Institute, 1 6, Minami hara, Tsukuba, Ibaraki, 305 8516 Japan
    Water Sci Technol 52:275-82. 2005
    ..Furthermore, after continuous 2-week exposure, the vitellogenin production of male medaka was reduced similar to the decrease of the concentrations of the estrone and the estrogenic activity of river water...
  74. pmc Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity
    Wade V Welshons
    Department of Veterinary Biomedical Sciences, Columbia, MO, USA
    Environ Health Perspect 111:994-1006. 2003
    ....
  75. ncbi Estrogenicity in bile of juvenile rainbow trout as measure of exposure and potential effects of endocrine disruptors
    Ann Sofie Allard
    Swedish Environmental Research Institute, P O Box 21060, SE 10031 Stockholm, Sweden
    Environ Toxicol Chem 23:1187-93. 2004
    ..Bile estrogenicity proved to be a useful and sensitive (internal) measure of exposure and indicated its potential for the display of biological effects as a complement or replacement of more laborious assays...
  76. ncbi The presence of morphologically intermediate papilla syndrome in United Kingdom populations of sand goby (Pomatoschistus spp): endocrine disruption?
    Mark F Kirby
    CEFAS, Burnham Laboratory, Remembrance Avenue, Burnham on Crouch, Essex, United Kingdom
    Environ Toxicol Chem 22:239-51. 2003
    ..The potential of the MIPS condition to significantly interfere with reproductive performance is discussed as well as its use as a monitoring tool for endocrine disruption in the estuarine environment...
  77. ncbi Impact of endocrine toxicants on survival, development, and reproduction of the estuarine copepod Eurytemora affinis (Poppe)
    Joëlle Forget-Leray
    Laboratory of Ecotoxicology, UPRES EA 3222, UFR de Sciences et Techniques, Universite du Havre, 25 rue Philippe Lebon, BP 540, 76058 Le Havre Cedex, France
    Ecotoxicol Environ Saf 60:288-94. 2005
    ..The results suggest that endocrine disruption could occur in copepods following exposure to estrogenic compounds, especially if they are exposed starting from embryonic development...
  78. ncbi Assessment of putative endocrine disrupters in an in vivo crustacean assay and an in vitro insect assay
    Nadine A Pounds
    Brixham Environmental Laboratory, AstraZeneca Global Safety Health and Environment, Devon, UK
    Mar Environ Res 54:709-13. 2002
    ..The implications for environmental monitoring of endocrine disrupters are discussed...
  79. ncbi An assessment of endocrine disrupting activity changes during wastewater treatment through the use of bioassays and chemical measurements
    Jörg E Drewes
    Environmental Science and Engineering Division, Colorado School of Mines, Golden 80401 1887, USA
    Water Environ Res 77:12-23. 2005
    ..For the majority of facilities, the remaining activity was likely attributed to residual concentrations of two steroidal hormones (17beta-estradiol and estriol)...
  80. ncbi Detection and evaluation of endocrine-disruption activity in water samples from Portuguese rivers
    Laia Quirós
    Department of Molecular Biology, IBMB CSIC, 08034 Barcelona, Spain
    Environ Toxicol Chem 24:389-95. 2005
    ..We conclude that estrogenic activity can be explained by alkylphenol contamination in only these sites; for the remainder, we propose that pesticides and urban waste may be the main factors responsible for estrogenic contamination...
  81. ncbi The effect of bisphenol A and chlorinated derivatives of bisphenol A on the level of serum vitellogenin in Japanese medaka (Oryzias latipes)
    A Tabata
    Institute of Environmental Ecology, Metocean Environment Inc, Oigawa cho, Shida gun, Shizuoka 421 0212, Japan
    Water Sci Technol 50:125-32. 2004
    ..The decrease in BPA and its chlorinated derivatives paralleled the decrease in estrogenic potency evaluated by the induction of vitellogenin (VTG) in the serum of mature male Japanese medaka...
  82. ncbi Plasma biomarkers in fish provide evidence for endocrine modulation in the Elbe River, Germany
    Markus Hecker
    Institute of Hydrobiology and Fisheries Science, University of Hamburg, Germany
    Environ Sci Technol 36:2311-21. 2002
    ..However, there was no single chemical that alone could explain the observed inhibitory effects on sexual development. The results indicate that the endocrine system in wild bream is disrupted in stretches of the Elbe River.
  83. ncbi Estrogenic potential of the Venice, Italy, lagoon waters
    Giulio Pojana
    Department of Environmental Sciences, University of Venice, Calle Larga S Marta, 2137, I 30123 Venice, Italy
    Environ Toxicol Chem 23:1874-80. 2004
    ..These levels are likely to pose adverse effects on the Venice lagoon aquatic organisms...
  84. ncbi Behaviour of endocrine disrupting chemicals during the treatment of municipal sewage sludge
    P Ivashechkin
    Institute of Environmental Engineering ISA, Aachen Technical University, Templergraben 55, Aachen 52056, Germany
    Water Sci Technol 50:133-40. 2004
    ..Addition of polymer is favourable in the case of sludge incineration. Conditioning with iron (III) chloride and calcium hydroxide shows advantages for the use of sludge as fertiliser...
  85. ncbi Effects of waterborne exposure to 4-nonylphenol on plasma sex steroid and vitellogenin concentrations in sexually mature male carp (Cyprinus carpio)
    D L Villeneuve
    Department of Zoology, Michigan State University, East Lansing 48824, USA
    Chemosphere 47:15-28. 2002
    ..Furthermore, they provide information regarding the concentrations and variability of E2, T, and VTG in the plasma of sexually mature male carp, which may aid in design and interpretation of future studies...
  86. ncbi Reduction of estrogenic activity of municipal wastewater by aerated lagoon treatment facilities
    Robert B Bringolf
    Iowa State University, Department of Animal Ecology, Ames, Iowa 50011 3221, USA
    Environ Toxicol Chem 22:77-83. 2003
    ....
  87. ncbi Deviation from additivity with estrogenic mixtures containing 4-nonylphenol and 4-tert-octylphenol detected in the E-SCREEN assay
    Nissanka Rajapakse
    Centre for Toxicology, School of Pharmacy, University of London, London, WC1N 1AX, United Kingdom
    Environ Sci Technol 38:6343-52. 2004
    ....
  88. ncbi Array technology as a tool to monitor exposure of fish to xenoestrogens
    Patrick Larkin
    Department of Biochemistry and Molecular Biology and Center for Biotechnology, Gainesville, FL 32610 USA
    Mar Environ Res 54:395-9. 2002
    ..The results of these experiments demonstrate a characteristic expression pattern of estrogen responsive genes in sheepshead minnows exposed to 17 beta-estradiol (E2)...
  89. ncbi Environmental endocrine disrupters dysregulate estrogen metabolism and Ca2+ homeostasis in fish and mammals via receptor-independent mechanisms
    Christopher J Kirk
    School of Biosciences, University of Birmingham, Edgbaston, B15 2TT Birmingham, UK
    Comp Biochem Physiol A Mol Integr Physiol 135:1-8. 2003
    ....
  90. pmc Relationship between reproductive success and male plasma vitellogenin concentrations in cunner, Tautogolabrus adspersus
    Lesley J Mills
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Narragansett, Rhode Island 02882, USA
    Environ Health Perspect 111:93-100. 2003
    ..Male plasma vitellogenin expression may serve as an indicator of reduced female reproductive function caused by estrogen exposure...
  91. ncbi Estrogenic responses of larval sunshine bass (Morone saxatilis x M. Chrysops) exposed to New York City sewage effluent
    Julia R Todorov
    Marine Sciences Research Center, State University of New York, Stony Brook 11794, USA
    Mar Environ Res 54:691-5. 2002
    ..The extremely higher concentrations of NPEOs found in effluent relative to hormones (approximately 40,000-fold) indicates that surfactant metabolites may be contributing significantly to the estrogenic effects observed...
  92. ncbi Dynamics of estrogen biomarker responses in rainbow trout exposed to 17beta-estradiol and 17alpha-ethinylestradiol
    Emma Thomas-Jones
    Molecular Light Technology Research, Cardiff Industrial Park, Cardiff, CF14 5DL, United Kingdom
    Environ Toxicol Chem 22:3001-8. 2003
    ..In conclusion, all biomarkers responded to estrogen exposure at environmentally relevant concentrations...
  93. ncbi The potential for oestrogenic effects of pesticides in headwater streams in the UK
    Mark R Hurst
    Centre for Environment, Fisheries and Aquaculture Science, Burnham Laboratory, Remembrance Avenue, Burnham on Crouch, Essex, CM0 8HA, UK
    Sci Total Environ 301:87-96. 2003
    ..The potential sources of the oestrogenic activity measured in the headwater streams are discussed...
  94. ncbi Fish test for endocrine-disruption and estimation of water quality of Japanese rivers
    Shosaku Kashiwada
    Institute of Environmental Ecology, Metocean Environment Inc, Shizuoka, Japan
    Water Res 36:2161-6. 2002
    ..Based on these FSP inducible concentrations and reported concentrations of E2, NP and BPA in Japanese river water, some river water contaminated by E2 or NP could be estimated as the FSP inducible in male medaka...
  95. ncbi Influence of parental and developmental cadmium exposure on endocrine and reproductive function in Japanese medaka (Oryzias latipes)
    Christy M Foran
    Environmental Toxicology Research Program, The University of Mississippi, University, MS 38677, USA
    Comp Biochem Physiol C Toxicol Pharmacol 133:345-54. 2002
    ..Hence, steroid parameters were a better biomarker of cadmium exposure than changes in VTG. However, reproductive impairment was not correlated to change in VTG or plasma steroids...
  96. pmc Abnormal bone composition in female juvenile American alligators from a pesticide-polluted lake (Lake Apopka, Florida)
    P Monica Lind
    Institute of Environmental Medicine, Karolinska Institutet, Institute of Environmental Medicine, PO Box 210, Nobels vag 13, plan 3, S 171 77 Stockholm, Sweden
    Environ Health Perspect 112:359-62. 2004
    ....
  97. ncbi On-line solid-phase extraction and fluorescence detection of selected endocrine disrupting chemicals in water by high-performance liquid chromatography
    Guang Guo Ying
    CSIRO Land and Water, Adelaide Laboratory, Glen Osmond SA, Australia
    J Environ Sci Health B 37:225-34. 2002
    ..The recoveries for these chemicals were more than 92% except for 4-NP with a recovery of 61%. This relatively simple method is useful for laboratory studies on the environmental fate of these endocrine disrupting chemicals in water...
  98. ncbi Gonadal histology and serum vitellogenin levels of bigeye tuna Thunnus obesus from the Northern Pacific Ocean--absence of endocrine disruption bio-indicators
    Shinya Hashimoto
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Mar Pollut Bull 46:459-65. 2003
    ..However, further studies are necessary to evaluate the health status of the open sea fishery resources...
  99. ncbi Effects of atrazine on fish, amphibians, and aquatic reptiles: a critical review
    Keith R Solomon
    Department of Environmental Biology and Centre for Toxicology, University of Guelph, Guelph, Ontario, Canada
    Crit Rev Toxicol 38:721-72. 2008
    ..For other responses, such as immune function, stress endocrinology, parasitism, or population-level effects, there are no indications of effects or there is such a paucity of good data that definitive conclusions cannot be made...
  100. ncbi Vitellogenin in tilapia male fishes exposed to organochlorine pesticides in Ouémé River in Republic of Benin
    Liliane Eustache Okoumassoun
    Universite du Quebec a Montreal, Département de Chimie et de Biochimie, Case Postale 8888, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3P8
    Sci Total Environ 299:163-72. 2002
    ..Eating fish from contaminated rivers, such as the Ouémé River, may contribute to the accumulation of high concentrations of these pesticides in the body, leading to exposure to their negative effects...
  101. ncbi Estrogenic activity in water and sediments of a French river: contribution of alkylphenols
    H Fenet
    Laboratoire de Chimie Analytique, Faculte de Pharmacie, Montpellier, France
    Arch Environ Contam Toxicol 44:1-6. 2003
    ..022 microg x g(-1) of nonylphenols) poorly contribute to the observed estrogenic activity. Other compounds, such as natural and synthetic hormones, present in water and sediments could act additively in the overall activity...

Research Grants64

  1. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..that safer and more effective therapeutic agents can be developed that act at targets of the thyroid hormone endocrine system. We recently discovered a novel class of endogenous compounds called thyronamines that are chemical ..
  2. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..that safer and more effective therapeutic agents can be developed that act at targets of the thyroid hormone endocrine system. We recently discovered a novel class of endogenous compounds called thyronamines that are chemical ..
  3. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK KUMAR SARKAR; Fiscal Year: 2013
    ..fetal alcohol exposed children show poor stress tolerance, immune system incompetence, and abnormalities in endocrine system functions...
  4. Molecular Physiology of the Epitrachael Endocrine System
    Michael E Adams; Fiscal Year: 2012
    ..Results of these studies also may provide basic new information about vector-borne human diseases involving mosquitoes, flies, ticks, and other arthropods. ..
  5. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK SARKAR; Fiscal Year: 2009
    ..fetal alcohol exposed children show poor stress tolerance, immune system incompetence, and abnormalities in endocrine system functions...
  6. Adipocyte Renin-Angiotensin System and Programming of Hypertension
    Mina Desai; Fiscal Year: 2010
    ..The underlying cause may be due to changes in a specific endocrine system (renin-angiotensin) which is present in adipose tissue and plays a key role in regulating blood pressure...
  7. Vitamin D and the Immune System
    Lawrence Steinman; Fiscal Year: 2012
    ..mechanisms involved will result in new concepts in our understanding of the interaction between the vitamin D endocrine system and the immune system that may suggest therapeutic targets for the control of MS and other TH17 dependent ..
  8. Interplay between the Endocrine and Innate Systems of Drosphila
    Neal Silverman; Fiscal Year: 2013
    ..The endocrine system, through steroids as well as sex hormones and vitamin D, has profound pro- or anti- inflammatory effects on ..
  9. Intragenic Suppressors of McCune-Albright Syndrome Mutations
    ROBIN PALS RYLAARSDAM; Fiscal Year: 2010
    ..puberty, and cafi-au-lait skin hyperpigentation, often accompanied by other disorders of a hyperfunctioning endocrine system. A single amino acid substitution in the heterotrimeric G-protein subunit Gs causes constitutive activation ..
  10. Bisphenol-A and Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2013
    ..EDC) are hormonally active, synthetic or natural chemicals that interfere with normal functioning of the endocrine system, most notably the reproductive endocrine axis...
  11. Ligand independent signaling by VDR in Keratinocytes
    Paul N MacDonald; Fiscal Year: 2010
    ..The focus of this research proposal is on the vitamin D endocrine system in epidermal keratinocytes and, specifically, on the use of murine models of the vitamin D endocrine system ..
  12. Environmentally Triggered Neurodevelopmental Disorders: Focus on Endocrine Disrup
    JOAN MARIE CRANMER; Fiscal Year: 2012
    ..The conference is designed to present attendees with the latest state-of-the-science about the role of the endocrine system in environmentally triggered disorders and stimulate vigorous discussion among experts from different ..
  13. Neuroendocrine and Neuroimaging Endophenotypes in Postpartum Depression
    KRISTINA MARIE DELIGIANNIDIS; Fiscal Year: 2013
    ..investigative techniques and train me in neuroimaging to investigate the interactions of the reproductive endocrine system on neural circuitry in depression so to elucidate the pathophysiology of depression during times of ..
  14. HTS to identify chemical probes of the apelin receptor signaling pathway
    Layton Harris Smith; Fiscal Year: 2010
    ..to elicit a variety of physiological effects on the heart and blood vessels, hypothalamus, and the endocrine system, but the role of apelin and APJ in vivo remains controversial...
  15. Molecular Mechanisms of Endocrine Disruption in Bass
    Nancy D Denslow; Fiscal Year: 2011
    Transient and permanent reproductive dysfunction in fish has been linked to chemicals that disrupt the endocrine system, but the mechanisms involved are unclear...
  16. Thyroid Hormone Action
    Thomas Scanlan; Fiscal Year: 2009
    ..that safer and more effective therapeutic agents can be developed that act at targets of the thyroid hormone endocrine system. We recently discovered a novel class of endogenous compounds called thyronamines that are chemical ..
  17. Cell non-autonomous function of the unfolded protein response
    ANDREW G DILLIN; Fiscal Year: 2013
    ..The endocrine system is thus an integral and necessary part of multiple conserved cellular stress response pathways...
  18. Inositol Signaling in C. elegans Senescence and Diapause
    GARY B RUVKUN; Fiscal Year: 2013
    ..the ribosome, the mitochondrion, the cytoskeleton, and if deficits are detected, the pathway couples to an endocrine system of longevity control that is distinct from the insulin-like pathway...
  19. Vitamin D Receptor Coactivators in Osteoblasts
    Paul N MacDonald; Fiscal Year: 2010
    1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the bioactive hormone of the vitamin D endocrine system. It functions via the vitamin D receptor (VDR) to impact bone by increasing intestinal calcium absorption and by directly affecting ..
  20. Menstrual Cycle Control of HIV Infection in the Reproductive Tract
    CHARLES ROBERT WIRA; Fiscal Year: 2013
    ..This study is unique in tht it integrates our understanding of the endocrine system and the immune system throughout the human FRT as it relates directly to the very cells most likely to be ..
  21. Genetic Mapping of Functional Vomeronasal Circuits
    CONGRONG RON YU; Fiscal Year: 2013
    ..The vomeronasal system is highly evolved in most vertebrate species and is specialized in controlling endocrine system and emotional states...
  22. Conditional ablation of Meningioma-1 in osteoblasts
    Paul N MacDonald; Fiscal Year: 2013
    ..These new data implicate MN1 in more global skeletal remodeling independent of VDR and the vitamin D endocrine system. This newest model has the potential to uncover new insight into potential mechanisms and biologies involved ..
  23. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
    ..EDCs) are hormonally active, synthetic or natural chemicals that interfere with normal functioning of the endocrine system. Exposure to EDCs continues to be a significant and contentious public health issue...
  24. Functions of Stem Cells in Pituitary Plasticity
    Xiaoyan Zhu; Fiscal Year: 2010
    ..hypopituitarism) or overproduction (pituitary tumors) of hormones lead to more than a dozen disorders of the endocrine system and has serious consequences for human health and quality of life...
  25. Prenatal Sex Steroids, Bisphenol A, Phthalates, and Sexually Dimorphic Behaviors
    Joseph M Braun; Fiscal Year: 2012
    ..The fetal brain is uniquely sensitive and environmental chemical exposures and dysregulation of the endocrine system may increase the risk of adverse neurobehavioral outcomes like autism, attention-deficit/hyperactivity ..
  26. Environmental obesogens reduce Thy1 expression and promote obesity
    Richard P Phipps; Fiscal Year: 2013
    ..Environmental toxicants termed obesogens disrupt the endocrine system and can increase adipogenesis...
  27. Neurobiological Correlates of Autonomic Dysfunction and Insulin Resistance
    John P Ryan; Fiscal Year: 2011
    ..This application will enable the Applicant to receive formal training in the physiology and pathology of the endocrine system that underlies T2D, as well as extend his training in functional neuroimaging to include advanced techniques ..
  28. Fragile X pre-mutation and ovarian insufficiency
    Katherine F Roby; Fiscal Year: 2013
    ..The granulosa, oocyte, and anterior pituitary form key components of the hypothalamic-pituitary-ovarian endocrine system important for normal fertility...
  29. PBDE Body Burdens, House Dust Concentrations and Associations with Thyroid Hormon
    Lyndsey Darrow; Fiscal Year: 2012
    ..facilitate investigation of PBDEs from sources in the environment to human body burdens to effects on the endocrine system in a vulnerable and understudied age group...
  30. ENDOCRINE REGULATION OF MATERNAL BEHAVIOR
    Robert Bridges; Fiscal Year: 2009
    ..A second series of experiments will determine the involvement of the endocrine system in ongoing maternal care...
  31. Screening method to identify environmental endocrine disruptors mediated by PPARs
    Michael I Luster; Fiscal Year: 2013
    ..Of particular concern, particularly in children, are those that may affect the endocrine system. The potential health significance of endocrine disruptors that act through peroxisome proliferator- ..
  32. Molecular Mechanisms of Atrazine in Altering the Endocrine Gene Network
    Holly A Ingraham; Fiscal Year: 2010
    ..EDCs) such as the herbicide atrazine (ATR) are widely used and are proposed to adversely affect the endocrine system. Although the consequences of EDCs on the reproductive health and viability of some wild life are established,..
  33. Osteogenic Maturation and Bone Repair Require 1,25- and 24,25-dihydroxyvitamin D
    KEVIN MATTHEW CURTIS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The vitamin D endocrine system is fundamental to health maintenance and disease prevention...
  34. Assessing maternal and fetal exposure to chemicals during the second trimester
    Tracey J Woodruff; Fiscal Year: 2012
    ..A large and growing base of science demonstrates that exposure to chemicals that can alter the function of the endocrine system during specific periods of fetal development can result in health consequences that manifest in childhood and ..
  35. BIOMECHANISMS OF TOOTH ERUPTION,RESORPTION & REPLACEMENT
    ZEEV DAVIDOVITCH; Fiscal Year: 1993
    ..and replacement, and related areas of cell-cell and cell-matrix interactions; nervous, immune, and endocrine system interactions in the regulation of connective tissue metabolism, with emphasis on regulatory mechanisms of ..
  36. Alterations of complex behaviors in sheep by pre-natal bisphenol A exposure
    Elizabeth M Peckham; Fiscal Year: 2013
    ..by applicant): Endocrine disrupting chemicals (EDC) are pollutants that disturb normal functioning of the endocrine system. Exposure to such pollutants during pre-natal development can have detrimental effects on the developing ..
  37. Dimensions in Endocrine Disruption: Altering Receptor Coregulator Interactions
    JILLIAN REBECCA GUNTHER; Fiscal Year: 2011
    ..Endocrine disrupters are exogenous compounds that interfere with the endocrine system, altering hormone action and the messages it sends throughout the body...
  38. Neuroendocrine Mechanisms of Developmental Massage Therapy in Preterm Infants
    Laurie Moyer Mileur; Fiscal Year: 2009
    ..PNS) branches of the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis of the endocrine system. PNS develops later in gestation (~37-38 weeks) and younger infants (<36 weeks) tend to have an overriding ..
  39. Prenatal Sex Steroids, Bisphenol A, Phthalates, and Sexually Dimorphic Behaviors
    Joseph M Braun; Fiscal Year: 2013
    Abstract: The fetal brain is uniquely sensitive and environmental chemical exposures and dysregulation of the endocrine system may increase the risk of adverse neurobehavioral outcomes like autism, attention-deficit/hyperactivity ..
  40. Roles of Stress and Glucocorticoids in Dopaminergic Projections and Behaviors
    Minae Niwa; Fiscal Year: 2013
    ..Nevertheless, mechanistic links of this endocrine system to dopaminergic neurons in the disease contexts remain elusive...
  41. Systemic responses to tissue damage and regeneration
    Megumi M Fuse; Fiscal Year: 2013
    ..discs, (ii) identify and characterize the factors released from the damaged discs providing signals to the endocrine system, and (ii) determine the actions of these blood-borne factors on the endocrine system...
  42. Brominated Flame Retardants: Multigenerational Endocrine Disruption?
    Michele Marcus; Fiscal Year: 2013
    ..and their children provides important information regarding exposure to chemicals that may disrupt the endocrine system across generations...
  43. Breast Cancer Genomics in Windows of Susceptibility to Endocrine Disruptors
    Susan L Teitelbaum; Fiscal Year: 2013
    ..Endocrine disrupters (EDs) are exogenous substances with hormonal activity in the endocrine system that disrupts the physiologic function of endogenous hormones...
  44. RNA as a Hormone: Systemic Signaling in Mammals via Circulating, Cell-Free Small
    Muneesh Tewari; Fiscal Year: 2013
    ..The conventional paradigm of the endocrine system does not include RNA molecules as a class of hormones...
  45. COMPARATIVE GENOMICS OF PARASITIC NEMATODES
    Makedonka Mitreva; Fiscal Year: 2013
    ..nematode-specific insertions and deletions in proteins involved in environmental information processing and endocrine system. The expected outcome will facilitate and promote the discovery and development of novel interventions to ..
  46. OSTEOPOROSIS/DIHYDROXYVITAMIN REGULATED GENE EXPRESSION
    Sylvia Christakos; Fiscal Year: 1993
    ..Our hypothesis is that aging results in an alteration in the vitamin D endocrine system and in 1,25 dihydroxyvitamin D (1,25(OH)3D3) regulated gene expression which results in a deterioration in ..
  47. MOLECULAR PHYSIOLOGY OF THE EPITRACHEAL ENDOCRINE SYSTEM
    Michael Adams; Fiscal Year: 2001
    ..We recently identified a novel, segmentally distributed endocrine system of epitracheal glands (EG) in Manduca sexta that produce "ecdysis- triggering hormone" (ETH)...
  48. VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL WOMEN
    John Aloia; Fiscal Year: 2002
    ..A secondary aim is to evaluate the changes in the vitamin D-endocrine system and indices of bone turnover that result from long term vitamin D3 augmentation...
  49. PRENATAL AND CHILDHOOD EXPOSURES AND AGE AT MENARCHE
    Gayle Windham; Fiscal Year: 2001
    ..Numerous studies have shown effects of alcohol on the endocrine system of adults and there is suggestive evidence it may effect sexual maturation...
  50. Regulation of minerals and fluids excretion in vitamin D
    Yan Chun Li; Fiscal Year: 2005
    ..vitamin D research, with a long-term objective of understanding the physiological functions of the vitamin D endocrine system. As Dr...
  51. MOLECULAR PHYSIOLOGY OF THE EPITRACHEAL ENDOCRINE SYSTEM
    Michael Adams; Fiscal Year: 2002
    ..The simplicity of the epitracheal endocrine system, composed of glands containing only 1-3 cells, provides an excellent model for examination of endocrine ..
  52. Neurobiology of Nicotine: Hormones and Behavior
    NANCY MELLO; Fiscal Year: 2007
    ..The role of the endocrine system in modulating the reinforcing effects of drugs is poorly understood, but recent preclinical and clinical ..
  53. AGE RELATED CHANGES IN PITUITARY LACTOTROPHS
    Phyllis Callahan; Fiscal Year: 1993
    ..Aging produces a number of alterations in many physiologic functions. Significant changes occur in the endocrine system, including alterations in anterior pituitary secretory function, most notable, an increase in prolactin ..
  54. ENZYMES INVOLVED IN DYNORPHIN BIOSYNTHESIS
    Lakshmi Devi; Fiscal Year: 1993
    ..Dynorphins may act both as neurotransmitters or neuromodulators in brain and as hormones in the endocrine system. They are thought to be involved in pain perception, intestinal peristalsis, feeding and sleep...
  55. ANIMAL MODELS OF MALE INFERTILITY
    Curtis Chubb; Fiscal Year: 1990
    ..studies is to elucidate the actions of these gene mutations on sexual behavior, sperm function, and the endocrine system. The studies combine genetics, behavioral science, endocrinology, and molecular biology in a physiological ..
  56. 2006 Environmental Endocrine Disruptors Gordon Conference
    Rex Hess; Fiscal Year: 2006
    ..accident in Seveso, Italy, an environmental disaster that has resulted in serious disruption of the human endocrine system; second, to highlight the most up-to-date science through discussions of cell signaling pathways that overlap ..
  57. ENDO 2013: The 95th Annual Meeting &Expo of The Endocrine Society
    Loretta L Doan; Fiscal Year: 2013
    ..and feature the latest, state-of-the art research on physiological and pathological issues related to the endocrine system. Historically, among the more than 7,000 scientific attendees at ENDO, nearly one-third have been trainees...
  58. Neuropeptide Y and dipeptidyl-peptidase IV (CD26) in chronic fatigue syndrome
    Mary Fletcher; Fiscal Year: 2007
    ..and pathophysiological processes in the cardiorespiratory system, immune system, nervous system and endocrine system. In the periphery, NPY is concentrated in the sympathetic nerve endings and is released alone or with ..
  59. BIOSYNTHESIS OF SECRETIN
    Alan Kopin; Fiscal Year: 1993
    ..investigator's training and research interests relate to the functions and regulation of the gastrointestinal endocrine system. The applicant is completing fellowship training in gastroenterology and is committed to a career of ..
  60. INNER EAR ADRENOCORTICOSTEROID RECEPTOR SYSTEM
    KYLE RAREY; Fiscal Year: 1992
    ..Such findings indicate that adrenal steroids modify inner ear tissues via a neuro-endocrine system. These data are the first to implicate the role of adrenal steroids in inner ear microhomeostasis...
  61. LUTEAL FUNCTION--ROLES OF GROWTH FACTORS AND ONCOGENES
    PAUL TSANG; Fiscal Year: 1990
    ..e. breast, ovarian, colon, bladder and stomach tumors in humans. Within the endocrine system, the mammalian role in cycle regulation and fertility control...
  62. REGULATION OF SF 1 EXPRESSION IN THE GONADS
    LESLIE HECKERT; Fiscal Year: 2000
    ..The transcription factor regulates a variety of genes important to the endocrine system and is essential for formation of adrenal glands and gonads...
  63. 1,25-DIHYDROXYVITAMIN D RECEPTOR/FUNCTION IN NEW TARGETS
    MARIAN WALTERS; Fiscal Year: 1991
    ..receptor levels in putative new target tissues correlate with physiological status of the vitamin D endocrine system. Effects of 1,25(OH)2D3 status and receptors on intracellular calcium homeostasis in heart and Sertoli cells ..
  64. EFFECTIVE NARCOTIC ANTAGONISTS
    Jack Fishman; Fiscal Year: 1980
    ..The role of the endocrine system in the biochemistry and pharmacology of endogenous and exogenous opiates will be studied by inducing ..