ovum

Summary

Summary: A mature haploid female germ cell extruded from the OVARY at OVULATION.

Top Publications

  1. ncbi Evolutionary ecology of progeny size in arthropods
    C W Fox
    Department of Entomology, University of Kentucky, Lexington 40546 0091, USA
    Annu Rev Entomol 45:341-69. 2000
  2. pmc Oviposition by pierid butterflies triggers defense responses in Arabidopsis
    Dawn Little
    Department of Plant Molecular Biology, University of Lausanne, 1015 Lausanne, Switzerland
    Plant Physiol 143:784-800. 2007
  3. ncbi PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development
    Christopher M Saunders
    Cell Signalling Laboratory, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff CF14 4XN, UK
    Development 129:3533-44. 2002
  4. ncbi A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro
    T Hirano
    Department of Pharmacology, University of California, San Francisco 94143 0450
    Cell 79:449-58. 1994
  5. pmc Capsule-transmitted gut symbiotic bacterium of the Japanese common plataspid stinkbug, Megacopta punctatissima
    Takema Fukatsu
    Research Institute of Biological Resources, National Institute of Advanced Industrial Science and Technology, Tsukuba 305 8566, Japan
    Appl Environ Microbiol 68:389-96. 2002
  6. ncbi Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts
    Jiangtao Yu
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Mol Cell 22:83-91. 2006
  7. pmc The structural determinants of checkpoint activation
    Christina A MacDougall
    Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305, USA
    Genes Dev 21:898-903. 2007
  8. ncbi Schistosome egg production is dependent upon the activities of two developmentally regulated tyrosinases
    Jennifer M Fitzpatrick
    Department of Pathology, University of Cambridge, Tennis Court Rd, CB2 1QP, UK
    FASEB J 21:823-35. 2007
  9. pmc Culture for genetic manipulation of developmental stages of Schistosoma mansoni
    Victoria H Mann
    Department of Microbiology, Immunology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Parasitology 137:451-62. 2010
  10. ncbi A method for the isolation of schistosome eggs and miracidia free of contaminating host tissues
    J P Dalton
    Molecular Parasitology Unit, Queensland Institute of Medical Research, Bancroft Centre, Royal Brisbane Hospital, Australia
    Parasitology 115:29-32. 1997

Research Grants

  1. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
  2. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
  3. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
  4. CTL response to AAV Vector
    Richard J Samulski; Fiscal Year: 2013
  5. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
  6. Site-directed Chemotherapy for Breast Cancer using Novel Angiogenesis Inhibitor
    Shaker A Mousa; Fiscal Year: 2010
  7. ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMA
    Kwang Chul Kim; Fiscal Year: 2010
  8. Validation of Novel Infertility Biomarker
    PETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012
  9. Functional Analysis of the Embryonic Epigenome in a Non-rodent Model
    Mark E Westhusin; Fiscal Year: 2013
  10. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012

Detail Information

Publications361 found, 100 shown here

  1. ncbi Evolutionary ecology of progeny size in arthropods
    C W Fox
    Department of Entomology, University of Kentucky, Lexington 40546 0091, USA
    Annu Rev Entomol 45:341-69. 2000
    ....
  2. pmc Oviposition by pierid butterflies triggers defense responses in Arabidopsis
    Dawn Little
    Department of Plant Molecular Biology, University of Lausanne, 1015 Lausanne, Switzerland
    Plant Physiol 143:784-800. 2007
    ..This study provides molecular evidence for the detection of egg deposition by Arabidopsis plants and suggests that oviposition causes a localized response with strong similarity to a hypersensitive response...
  3. ncbi PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development
    Christopher M Saunders
    Cell Signalling Laboratory, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff CF14 4XN, UK
    Development 129:3533-44. 2002
    ..Our results are consistent with sperm PLC zeta as the molecular trigger for development of a fertilised egg into an embryo...
  4. ncbi A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro
    T Hirano
    Department of Pharmacology, University of California, San Francisco 94143 0450
    Cell 79:449-58. 1994
    ..These motifs are highly conserved in a protein family, members of which have been identified recently in both prokaryotes and eukaryotes...
  5. pmc Capsule-transmitted gut symbiotic bacterium of the Japanese common plataspid stinkbug, Megacopta punctatissima
    Takema Fukatsu
    Research Institute of Biological Resources, National Institute of Advanced Industrial Science and Technology, Tsukuba 305 8566, Japan
    Appl Environ Microbiol 68:389-96. 2002
    ....
  6. ncbi Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts
    Jiangtao Yu
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Mol Cell 22:83-91. 2006
    ..These results demonstrate that Greatwall participates in an autoregulatory loop that generates and maintains sufficiently high MPF activity levels to support mitosis...
  7. pmc The structural determinants of checkpoint activation
    Christina A MacDougall
    Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305, USA
    Genes Dev 21:898-903. 2007
    ..These observations define the minimal DNA requirements for checkpoint activation and suggest that primed ssDNA represents a common checkpoint activating-structure formed following many types of damage...
  8. ncbi Schistosome egg production is dependent upon the activities of two developmentally regulated tyrosinases
    Jennifer M Fitzpatrick
    Department of Pathology, University of Cambridge, Tennis Court Rd, CB2 1QP, UK
    FASEB J 21:823-35. 2007
    ....
  9. pmc Culture for genetic manipulation of developmental stages of Schistosoma mansoni
    Victoria H Mann
    Department of Microbiology, Immunology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Parasitology 137:451-62. 2010
    ..We also discuss recent advances in genetic manipulation of schistosomes including the deployment of square wave electroporation to introduce reporter genes into cultured schistosomes...
  10. ncbi A method for the isolation of schistosome eggs and miracidia free of contaminating host tissues
    J P Dalton
    Molecular Parasitology Unit, Queensland Institute of Medical Research, Bancroft Centre, Royal Brisbane Hospital, Australia
    Parasitology 115:29-32. 1997
    ..Using this procedure sufficient quantities of miracidia were obtained to generate a cDNA library. Southern blot analysis demonstrated that miracidia isolated by this method were free from contaminating host DNA...
  11. ncbi Insect egg deposition induces indirect defense and epicuticular wax changes in Arabidopsis thaliana
    Beatrice Blenn
    Institute of Biology, Freie Universitat Berlin, Berlin, Germany
    J Chem Ecol 38:882-92. 2012
    ..The ecological relevance of this finding is discussed with respect to its impact on the behavior of egg parasitoids...
  12. pmc Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts
    Emily E Arias
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:114-26. 2005
    ..Our results identify a replication-dependent proteolytic pathway that targets Cdt1 and that acts redundantly with geminin to inactivate Cdt1 in S phase...
  13. pmc Temperature-dependent development of the two-spotted ladybeetle, Adalia bipunctata, on the green peach aphid, Myzus persicae, and a factitious food under constant temperatures
    Mohammad Amin Jalali
    Department of Crop Protection, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Insect Sci 10:124. 2010
    ..Similar thermal constants of 267.9DD (on the aphid diet) and 266.3DD (on the factitious food) were calculated for the total development of A. bipunctata, indicating the nutritional value of the factitious food...
  14. pmc Long-term survival of hydrated resting eggs from Brachionus plicatilis
    Melody S Clark
    British Antarctic Survey, Natural Environment Research Council, High Cross, Cambridge, United Kingdom
    PLoS ONE 7:e29365. 2012
    ....
  15. pmc Maternal effects, flight versus fecundity trade-offs, and offspring immune defence in the speckled wood butterfly, Pararge aegeria
    Melanie Gibbs
    Behavioural Ecology and Conservation Group, Biodiversity Research Centre, Earth and Life Institute, Universite Catholique de Louvain UCL, Louvain la Neuve, Belgium
    BMC Evol Biol 10:345. 2010
    ....
  16. ncbi The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cells
    Joseph K Park
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390
    Curr Biol 17:533-8. 2007
    ..Our study strongly suggests that miRNAs play an intrinsic, but not extrinsic, role in Drosophila female GSC self-renewal...
  17. ncbi Avian vision and the evolution of egg color mimicry in the common cuckoo
    Mary Caswell Stoddard
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Evolution 65:2004-13. 2011
    ..Finally, cuckoos with better background color mimicry also have better pattern mimicry. Our findings reveal new information about egg mimicry that would be impossible to derive by the human eye...
  18. ncbi Effect of the chitin synthesis inhibitor triflumuron on the development, viability and reproduction of Aedes aegypti
    Thiago Affonso Belinato
    Laboratório de Fisiologia e Controle de Artrópodes Vetores, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, 21045 900 Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 104:43-7. 2009
    ..Triflumuron-surviving females ingested roughly 30% less blood and laid 25% fewer eggs than the control females. The treated males and females exhibited a diminished ability to copulate, resulting in less viable eggs...
  19. ncbi Cold season mortality and hatching behavior of Aedes aegypti L. (Diptera: Culicidae) eggs in Buenos Aires City, Argentina
    Sylvia Fischer
    Grupo de Estudio de Mosquitos, Departamento de Ecologia, Genetica y Evolucion, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
    J Vector Ecol 36:94-9. 2011
    ..Our results provide the first information of Ae. aegypti egg mortality in temperate South America and support the hypothesis that differences in egg mortality are associated with abundance patterns of Ae. aegypti in Buenos Aires city...
  20. pmc Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins
    P J Gillespie
    CRC Chromosome Replication Research Group, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, UK
    BMC Biochem 2:15. 2001
    ..Mcm2-7 are essential for DNA replication, but are displaced from origins as they initiate, thus ensuring that no origin fires more than once in a single cell cycle...
  21. ncbi Calcium signals and mitochondria at fertilisation
    Remi Dumollard
    Laboratoire de Biologie du Developpement, UMR 7009 CNRS UPMC, Station Zoologique, Observatoire, 06230 Villefranche sur Mer, France
    Semin Cell Dev Biol 17:314-23. 2006
    ....
  22. pmc Enterobius vermicularis eggs discovered in coprolites from a medieval Korean mummy
    Dong Hoon Shin
    Department of Anatomy, Seoul National University College of Medicine, Seoul 110 799, Korea
    Korean J Parasitol 49:323-6. 2011
    ..From them, 3 eggs of E. vermicularis were recovered. They were elliptical, transparent with a thin egg shell, 50.3±5.2 µm (length) and 28.2±3.9 µm (width) in size. This is the first discovery of E. vermicularis eggs in East Asia...
  23. ncbi Post-hatching parental care masks the effects of egg size on offspring fitness: a removal experiment on burying beetles
    K M Monteith
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    J Evol Biol 25:1815-22. 2012
    ..These findings suggest that the trade-off between number and size of offspring is shifted from the egg stage towards the end of the parental care period and that post-hatching parental care somehow moderates this trade-off...
  24. pmc The type and timing of social information alters offspring production
    Robert J Fletcher
    Department of Wildlife Ecology and Conservation, University of Florida, PO Box 110430, 110 Newins Ziegler Hall, Gainesville, FL 32611 0430, USA
    Biol Lett 4:482-5. 2008
    ..We conclude that the type and timing of social information may have an important, yet unappreciated, influence on reproductive allocation...
  25. ncbi First proteome of the egg perivitelline fluid of a freshwater gastropod with aerial oviposition
    Jin Sun
    Department of Biology, Hong Kong Baptist University, Hong Kong, China
    J Proteome Res 11:4240-8. 2012
    ..Characterization of the PVF proteome has opened the gate for further studies aiming to understand the evolution of the novel proteins and their contribution to the switch to aerial oviposition...
  26. ncbi Insect eggs suppress plant defence against chewing herbivores
    Friederike Bruessow
    Department of Plant Molecular Biology, University of Lausanne, CH 1015 Lausanne, Switzerland
    Plant J 62:876-85. 2010
    ..We show here that egg-induced SA accumulation negatively interferes with the JA pathway, and provides an advantage for generalist herbivores...
  27. ncbi Resource acquisition, allocation, and utilization in parasitoid reproductive strategies
    Mark A Jervis
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    Annu Rev Entomol 53:361-85. 2008
    ..The idea that parasitoids can be divided into capital-breeders or income-breeders is no longer tenable; such terminology is best restricted to the females' utilization of particular nutrients...
  28. ncbi Tardigrade Resistance to Space Effects: first results of experiments on the LIFE-TARSE mission on FOTON-M3 (September 2007)
    Lorena Rebecchi
    Department of Animal Biology, University of Modena and Reggio Emilia, 41100, Modena, Italy
    Astrobiology 9:581-91. 2009
    ..During the flight mission, tardigrades molted, and females laid eggs. Several eggs hatched, and the newborns exhibited normal morphology and behavior...
  29. ncbi A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response
    Laura Howell
    Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen AB24 2TZ, UK
    Immunogenetics 64:155-61. 2012
    ..Many of the genes with an encapsulation defect have mammalian homologues involved in cellular adhesion, wound healing, and thrombosis, including extracellular matrix proteins, cellular adhesion molecules, and small GTPases...
  30. pmc PLCζ causes Ca(2+) oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P(2)
    Yuansong Yu
    Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom
    Mol Biol Cell 23:371-80. 2012
    ....
  31. pmc Egg colour reflects the amount of yolk maternal antibodies and fledging success in a songbird
    Judith Morales
    Departamento de Ecologia Evolutiva, Museo Nacional de Ciencias Naturales CSIC, Jose Gutierrez Abascal 2, 28006 Madrid, Spain
    Biol Lett 2:334-6. 2006
    ..These results support the signalling hypothesis of eggshell coloration, underlining its role as an indicator of trans-generational transmission of immune defences in birds...
  32. pmc The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)
    Svenja Steinfelder
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:1681-90. 2009
    ..Based on this evidence, we hypothesize that S. mansoni omega-1 acts by limiting the interaction of DCs with CD4(+) T lymphocytes, thereby lowering the strength of the activation signal delivered...
  33. pmc Effect of insecticide resistance on development, longevity and reproduction of field or laboratory selected Aedes aegypti populations
    Ademir Jesus Martins
    Laboratório de Fisiologia e Controle de Artrópodes Vetores, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 7:e31889. 2012
    ....
  34. pmc Replication origins in Xenopus egg extract Are 5-15 kilobases apart and are activated in clusters that fire at different times
    J J Blow
    Cancer Research Campaign, Chromosome Replication Research Group, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Cell Biol 152:15-25. 2001
    ..This suggests that the binding of ORCs to chromatin determines the regular spacing of origins in this system...
  35. ncbi Developmental potential of embryonic cells in a nucleocytoplasmic hybrid formed using a goldfish haploid nucleus and loach egg cytoplasm
    Takafumi Fujimoto
    Laboratory of Aquaculture Genetics and Genomics, Division of Marine Life Science, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido, Japan
    Int J Dev Biol 54:827-35. 2010
    ..Thus, embryonic cells from nucleocytoplasmic hybrids that arrest before gastrulation could survive beyond the somitogenesis stage depending on the cytoplasmic environment in the recipient embryos...
  36. pmc Symptoms after ingestion of pig whipworm Trichuris suis eggs in a randomized placebo-controlled double-blind clinical trial
    Peter Bager
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 6:e22346. 2011
    ..In conclusion, during the first 2 months, repeated ingestions of 2500 T. suis eggs caused frequent gastrointestinal reactions lasting up to 14 days, whereas 4 months further treatment mainly provoked a subclinical stimulation...
  37. ncbi Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila
    J R Huynh
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, CB21QR, Cambridge, United Kingdom
    Curr Biol 11:901-6. 2001
    ..elegans and Drosophila, the relationships between them are different, as the localization of PAR-1 does not require Bazooka or PAR-6 in Drosophila, as it does in the worm...
  38. ncbi The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively
    Yinhua Zhang
    New England Biolabs Inc, 240 County Road, Ipswich, MA 01938, USA
    Dev Biol 285:330-9. 2005
    ..Knocking down chs-2 by RNAi caused a defect in the pharynx and led to L1 larval arrest, indicating that chitin is involved in the development and function of the pharynx...
  39. ncbi PLCzeta(zeta): a sperm protein that triggers Ca2+ oscillations and egg activation in mammals
    K Swann
    Department of Obstetrics and Gynaecology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Semin Cell Dev Biol 17:264-73. 2006
    ..We review the evidence that PLCzeta represents the sperm factor that activates development of the egg and discuss the characteristics of PLCzeta that distinguish it from the somatic forms of PLC...
  40. pmc Development without germ cells: the role of the germ line in zebrafish sex differentiation
    Krasimir Slanchev
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 102:4074-9. 2005
    ..Our results demonstrate an unexpected role for the germ line in promoting female development because PGC-ablated fish invariably developed as males...
  41. ncbi Conserved role of nanos proteins in germ cell development
    Masayuki Tsuda
    Division of Mammalian Development, National Institute of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Science 301:1239-41. 2003
    ..Hence, although mice and flies differ in their mechanisms for germ cell specification, there seems to be conserved function for nanos proteins among invertebrates and vertebrates...
  42. ncbi Ontogenetic variation in the chemical defenses of cane toads (Bufo marinus): toxin profiles and effects on predators
    R Andrew Hayes
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
    J Chem Ecol 35:391-9. 2009
    ..Our results suggest a dramatic ontogenetic shift in the danger that toads pose to native predators, reflecting rapid changes in the types and amounts of toxins during toad development...
  43. ncbi Methods for studying spindle assembly and chromosome condensation in Xenopus egg extracts
    Thomas J Maresca
    Department of Molecular and Cell Biology, University of California, Berkeley, USA
    Methods Mol Biol 322:459-74. 2006
    ....
  44. ncbi Cold acclimation and overwintering of female Aedes albopictus in Roma
    Roberto Romi
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Roma, Italy
    J Am Mosq Control Assoc 22:149-51. 2006
    ....
  45. pmc Ubiquitin/SUMO modification of PCNA promotes replication fork progression in Xenopus laevis egg extracts
    Craig A Leach
    The Biological Laboratories, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Cell Biol 171:947-54. 2005
    ..Furthermore, they suggest that PCNA monoubiquitylation serves as a molecular gas pedal that controls the speed of replisome movement during S phase...
  46. ncbi Insect egg deposition induces Pinus sylvestris to attract egg parasitoids
    Monika Hilker
    Institut fur Biologie, Freie Universitat Berlin, Haderslebener Strasse 9, D 12163 Berlin, Germany
    J Exp Biol 205:455-61. 2002
    ..Thus, the plant appears to defend itself against herbivores prior to being damaged by feeding larvae...
  47. pmc Male-derived butterfly anti-aphrodisiac mediates induced indirect plant defense
    Nina E Fatouros
    Department of Plant Sciences, Laboratory of Entomology, Wageningen University, PO Box 8031, 6700 EH Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 105:10033-8. 2008
    ..Our results suggest that the anti-aphrodisiac pheromone incurs fitness costs for the butterfly by both mediating phoretic behavior and inducing plant defense...
  48. ncbi Oogenesis in teleosts: how eggs are formed
    Esther Lubzens
    Department of Marine Biology, Israel Oceanographic and Limnological Research, 81080 Haifa, Israel
    Gen Comp Endocrinol 165:367-89. 2010
    ..The role of blood-borne and local ovarian factors in the regulation of the key steps of development reveal new aspects associated with egg formation...
  49. ncbi Reproductive output of female Anopheles gambiae (Diptera: Culicidae): comparison of molecular forms
    A S Yaro
    Malaria Research and Training Center, 1805, Point G Bamako, Mali
    J Med Entomol 43:833-9. 2006
    ..A greater investment per offspring coupled with larger egg batch size may reflect an adaptation of the M form to low productivity larval sites as independent evidence suggests...
  50. pmc Drosophila follicle cells: morphogenesis in an eggshell
    Xiaodong Wu
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Semin Cell Dev Biol 19:271-82. 2008
    ..Understanding intrinsic mechanisms that alter responses to developmental signals will be important to understand regulation of cell shape and organization...
  51. ncbi Facultative but persistent trans-generational immunity via the mother's eggs in bumblebees
    Ben M Sadd
    Curr Biol 17:R1046-7. 2007
    ..Additionally, eggs from immune-challenged mothers are imbued with increased internal antibacterial activity when they are laid...
  52. pmc Adaptive sequence evolution in a color gene involved in the formation of the characteristic egg-dummies of male haplochromine cichlid fishes
    Walter Salzburger
    Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University Konstanz, 78457 Konstanz, Germany
    BMC Biol 5:51. 2007
    ..One characteristic feature of the haplochromines is their possession of egg-dummies on the males' anal fins. These egg-spots mimic real eggs and play an important role in the mating system of these maternal mouthbrooding fish...
  53. ncbi The evolution of polyandry: intrinsic sire effects contribute to embryo viability
    F Garcia-Gonzalez
    Evolutionary Biology Research Group, School of Animal Biology M092, The University of Western Australia, Nedlands, Australia
    J Evol Biol 18:1097-103. 2005
    ..Additive genetic contributions to embryo viability may be an important factor underlying the frequently observed benefits of polyandrous behaviour...
  54. pmc An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti
    Mark R Brown
    Departments of Entomology and Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 105:5716-21. 2008
    ..Overall, our results identify ILP3 as a critical regulator of egg production by A. aegypti...
  55. ncbi Mechanisms of reproductive isolation among sympatric broadcast-spawning corals of the Montastraea annularis species complex
    Don R Levitan
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 1100, USA
    Evolution 58:308-23. 2004
    ....
  56. ncbi The making of symbiont capsule in the plataspid stinkbug Megacopta punctatissima
    Takahiro Hosokawa
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba 305 8566, Japan
    FEMS Microbiol Ecol 54:471-7. 2005
    ..Ecological and evolutionary implications of the highly developed, female-specific system for symbiont transmission were discussed...
  57. ncbi Egg size and offspring quality: a meta-analysis in birds
    Milos Krist
    Museum of Natural History, Nám Republiky 5, 771 73 Olomouc, Czech Republic
    Biol Rev Camb Philos Soc 86:692-716. 2011
    ..However, more studies that control for potential confounding effects of parental post-hatching care, genes, and egg composition are needed to establish firmly this causal link...
  58. ncbi Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein
    T Hirano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 89:511-21. 1997
    ..Our results suggest that the condensin complexes represent the most abundant structural components of mitotic chromosomes and play a central role in driving chromosome condensation...
  59. ncbi How many symbionts are provided by mothers, acquired by offspring, and needed for successful vertical transmission in an obligate insect-bacterium mutualism?
    Takahiro Hosokawa
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba 305 8566, Japan
    Mol Ecol 16:5316-25. 2007
    ..These results illuminate several ecological factors that may be relevant to parental and offspring controls over symbiotic resource allocation through host insect generations...
  60. ncbi Role of importin-beta in coupling Ran to downstream targets in microtubule assembly
    C Wiese
    Department of Embryology, Howard Hughes Medical Institute, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Science 291:653-6. 2001
    ..Importin-beta therefore links NuMA to regulation by Ran. This suggests that similar mechanisms regulate nuclear import during interphase and spindle assembly during mitosis...
  61. pmc CD9 tetraspanin generates fusion competent sites on the egg membrane for mammalian fertilization
    Antoine Jégou
    Laboratoire de Physique Statistique, Ecole Normale Supérieure de Paris, Universite Pierre et Marie Curie, Universite Paris Diderot, Centre National de la Recherche Scientifique, 24 rue Lhomond, 75005 Paris, France
    Proc Natl Acad Sci U S A 108:10946-51. 2011
    ..The CD9-induced adhesion sites would be the actual location where fusion occurs...
  62. ncbi Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection
    P G Fallon
    Department of Pathology, University of Cambridge, United Kingdom
    J Immunol 162:4122-32. 1999
    ..This study demonstrates that mice tolerized to schistosome eggs have elevated type 1 cytokine responses with diminished type 2 responses and reduced anti-egg Ab during schistosome infection, and these effects are detrimental to the host...
  63. ncbi The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells
    Matthias Hesse
    Laboratories of Parasitic Diseases and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:3157-66. 2004
    ..Thus, innate effectors and regulatory T cells producing IL-10 cooperate to reduce morbidity and prolong survival in schistosomiasis...
  64. pmc Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses
    Bart Everts
    Department of Parasitology, Leiden University Medical Centre, Leiden 2333 ZA, The Netherlands
    J Exp Med 206:1673-80. 2009
    ..Collectively, we identify omega-1, a single component of SEA, as a potent inducer of Th2 responses...
  65. pmc Requirement for Nudel and dynein for assembly of the lamin B spindle matrix
    Li Ma
    Laboratory of Molecular Cell Biology and Center of Cell Signaling, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Nat Cell Biol 11:247-56. 2009
    ..We suggest that Nudel regulates microtubule organization in part by facilitating assembly of the lamin B spindle matrix in a dynein-dependent manner...
  66. ncbi Allele-specific expression of imprinted genes in mouse migratory primordial germ cells
    PIROSKA E SZABO
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010 3011, USA
    Mech Dev 115:157-60. 2002
    ..The first three genes were expressed monoallelically, while the latter gene was expressed biallelically. These results show that inherited imprints regulating monoallelic expression are largely intact in migrating PGCs...
  67. ncbi Demography of gut symbiotic and aposymbiotic Nezara viridula L. (Hemiptera: Pentatomidae)
    Simone S Prado
    Department of Plant and Environmental Protection Sciences, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Environ Entomol 38:103-9. 2009
    ..96 +/- 4.43 d), regardless of the surface sterilization treatment. Our results highlight the effect that temperature has on the maintenance of this symbiosis and its relationship with N. viridula host's development and reproduction...
  68. ncbi Rat eggs cannot wait: Spontaneous exit from meiotic metaphase-II arrest
    Tatiana Chebotareva
    MRC Centre for Regenerative Medicine, Edinburgh University, Edinburgh, Scotland, UK
    Mol Reprod Dev 78:795-807. 2011
    ..This review examines the known predisposing factors and biochemical mechanisms involved in spontaneous activation. The strategies used to prevent spontaneous metaphase-II release in rat eggs will also be discussed...
  69. ncbi Parental care trade-offs and life-history relationships in insects
    James D J Gilbert
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
    Am Nat 176:212-26. 2010
    ..These patterns lay the groundwork for a more general understanding of parental care and life history...
  70. ncbi Aedes albopictus (Diptera: Culicidae) population size survey in the 2007 chikungunya outbreak area in Italy. II: Estimating epidemic thresholds
    M Carrieri
    Medical and Veterinary Entomology, Centro Agricoltura Ambiente G Nicoli, Via Argini Nord 3351, 40014 Crevalcore BO, Italy
    J Med Entomol 49:388-99. 2012
    ..The identification of an epidemic threshold based on the mean egg density may define the high risk areas and focus control programs...
  71. ncbi Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts
    Domenico Maiorano
    Institute of Human Genetics, Centre National de la Recherche Scientifique, 141 rue de la Cardonille, 34396 Montpellier, France
    Curr Biol 15:146-53. 2005
    ..These results suggest that removal of Cdt1 from chromatin and its nuclear exclusion in G2 is critical in regulating licensing and that override of this control is sufficient to promote illegitimate firing of origins...
  72. ncbi Juxtaposition between two cell types is necessary for dorsal appendage tube formation
    Ellen J Ward
    Department of Genome Sciences, University of Washington, Box 357730, Seattle, WA 98195 7730, USA
    Mech Dev 122:241-55. 2005
    ..We propose that signaling across a boundary separating the rho-lacZ and Broad cells choreographs the cell shape-changes and rearrangements necessary to transform an initially flat epithelium into a tube...
  73. pmc Strategic female reproductive investment in response to male attractiveness in birds
    Terézia Horváthová
    Department of Zoology, Edward Grey Institute, University of Oxford, Oxford OX1 3PS, UK
    Proc Biol Sci 279:163-70. 2012
    ....
  74. pmc Comprehensive egg coat proteome of the ascidian Ciona intestinalis reveals gamete recognition molecules involved in self-sterility
    Lixy Yamada
    Division of Disease Proteomics, Institute for Enzyme Research, The University of Tokushima, 3 15 18 Kuramoto cho, Tokushima 770 8503, Japan
    J Biol Chem 284:9402-10. 2009
    ....
  75. ncbi An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63
    Eloise Smith
    Genome Stability Unit, London Research Institute, Clare Hall Laboratories, South Mimms, London EN6 3LD, UK
    Nat Cell Biol 11:278-85. 2009
    ..These data indicate that ATM and ATR control mitotic events in vertebrate cells by targeting CEP63 and centrosome dependent spindle assembly...
  76. pmc An elm EST database for identifying leaf beetle egg-induced defense genes
    Kerstin Buchel
    Freie Universitat Berlin, Applied Zoology Animal Ecology, Berlin, Germany
    BMC Genomics 13:242. 2012
    ..Little is known about the transcriptional changes that insect eggs trigger in plants and how such indirect defense mechanisms are orchestrated in the context of other biological processes...
  77. ncbi Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles
    M E Pepling
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, 115 W. University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 234:339-51. 2001
    ..Cysts may ensure that oocytes destined to form primordial follicles acquire populations of functional mitochondria, through an active process that has been evolutionarily conserved...
  78. ncbi PKC signaling at fertilization in mammalian eggs
    Guillaume Halet
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Biochim Biophys Acta 1742:185-9. 2004
    ..Here, I review the recent development of PKC research in mammalian fertilization and the evidence for a specific role for certain PKC isotypes in fertilization-induced egg activation...
  79. ncbi Extraction and analysis of colourful eggshell pigments using HPLC and HPLC/electrospray ionization tandem mass spectrometry
    A Gorchein
    MRC Bioanalytical Science Group, School of Biological and Chemical Sciences, Birkbeck, University of London, Malet Street, London WC1E7HX, UK
    Biomed Chromatogr 23:602-6. 2009
    ..An explanation is advanced for the exceptional report that all porphyrins from uroporphyrin to protoporphyrin were found in eggshells of the fowl Gallus domesticus...
  80. pmc Plant volatiles induced by herbivore egg deposition affect insects of different trophic levels
    Nina E Fatouros
    Laboratory of Entomology, Research Centre, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 7:e43607. 2012
    ..Our findings imply that prior to actual feeding damage, egg deposition can induce specific plant responses that significantly influence various members of higher trophic levels...
  81. pmc Discovery of taeniid eggs from a 17th century tomb in Korea
    Hye Jung Lee
    Department of Parasitology and Research Center for Mummy, College of Medicine, Dankook University, Cheonan 330 714, Korea
    Korean J Parasitol 49:327-9. 2011
    ..5-40.0 µm×37.5 µm in size. This is the first report on taeniid eggs from ancient samples of Korea, and it is suggested that intensive examination of voluminous archeological samples should be needed for identification of Taenia spp...
  82. pmc Mode of action of methoprene in affecting female reproduction in the African malaria mosquito, Anopheles gambiae
    Hua Bai
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    Pest Manag Sci 66:936-43. 2010
    ..Previous studies in mosquitoes showed that 20-hydroxyecdysone (20E) regulates vitellogenin synthesis. However, the action of JH and its mimics, e.g. methoprene, on female reproduction of mosquitoes remains unknown...
  83. ncbi Effects of juvenile hormone analogs and 20-hydroxyecdysone on diapause termination in eggs of Locusta migratoria and Oxya yezoensis
    Kurako Kidokoro
    Division of Molecular Science, Graduate School of Science and Technology, Kobe University, 1 1 Rokkodaicho, Nada Ku, Kobe 657 8501, Japan
    J Insect Physiol 52:473-9. 2006
    ..The possible involvement of the hormones and ERK in embryonic diapause and the possibility of ecdysteroids synthesis by prothoracic glands of diapause embryo were proposed...
  84. ncbi Effect of low temperatures on mortality and oviposition in conjunction with climate mapping to predict spread of the root weevil Diaprepes abbreviatus and introduced natural enemies
    Stephen L Lapointe
    USDA ARS, U S Horticultural Research Laboratory, 2001 South Rock Rd, Fort Pierce, FL 34945, USA
    Environ Entomol 36:73-82. 2007
    ..By this measure, we predict that egg parasitoids will not establish in Arizona, California, or Texas...
  85. ncbi Sea urchin eggs in the acid reign
    Anthony J Morgan
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, United Kingdom
    Cell Calcium 50:147-56. 2011
    ..This review attempts to summarize what we currently know about egg acidic vesicles in the context of Ca(2+) signalling. The dynamics of Ca(2+) storage, Ca(2+) mobilization, proton fluxes and two-pore channels will be discussed...
  86. ncbi The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo
    James Stallock
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 130:6589-97. 2003
    ..Together, these observations identify the major mechanism that removes ectopic germ cells from the embryo at early stages...
  87. ncbi Chemical analysis of volatiles emitted by Pinus svlvestris after induction by insect oviposition
    Roland Mumm
    Institute of Biology, Freie Universitat Berlin, Haderslebener Str 9, 12163 Berlin, Germany
    J Chem Ecol 29:1235-52. 2003
    ..The release of terpenoids by pine after wounding, egg deposition, and JA treatment is discussed with special respect to (E)-beta-farnesene...
  88. ncbi A study on distribution and seasonal abundance of Aedes albopictus (Diptera: Culicidae) population in Athens, Greece
    Athanassios Giatropoulos
    Laboratory of Insecticides of Public Health Importance, Benaki Phytopathological Institute, 8 S Delta Str, 145 61 Kifissia, Athens, Greece
    J Med Entomol 49:262-9. 2012
    ..The current study suggests the necessity of setting up in the city of Athens an integrated surveillance program in a greater scale for Asian tiger mosquito's effective control...
  89. ncbi In infection with Schistosoma mansoni, B cells are required for T helper type 2 cell responses but not for granuloma formation
    H J Hernandez
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 158:4832-7. 1997
    ..These results suggest that B cells promote Th2-type responses, and that typical granulomatous responses proceed in their absence...
  90. pmc Visual modeling shows that avian host parents use multiple visual cues in rejecting parasitic eggs
    Claire N Spottiswoode
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Proc Natl Acad Sci U S A 107:8672-6. 2010
    ....
  91. ncbi The roles of Ca2+, downstream protein kinases, and oscillatory signaling in regulating fertilization and the activation of development
    Tom Ducibella
    Department of Ob Gyn, Tufts New England Medical Center, Boston, MA 02111, USA
    Dev Biol 315:257-79. 2008
    ....
  92. pmc Serodiagnosis of imported schistosomiasis by a combination of a commercial indirect hemagglutination test with Schistosoma mansoni adult worm antigens and an enzyme-linked immunosorbent assay with S. mansoni egg antigens
    Tom van Gool
    Department of Microbiology, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, The Netherlands
    J Clin Microbiol 40:3432-7. 2002
    ..The combined use of these two tests enabled the serological diagnosis of schistosomiasis to be achieved with very high degrees of both sensitivity and specificity...
  93. ncbi Does interspecific competition affect offspring provisioning?
    Dustin J Marshall
    School of Integrative Biology, The University of Queensland, Brisbane, Queensland 4072, Australia
    Ecology 90:487-95. 2009
    ..This study shows that, while offspring size is plastic in this species, post-metamorphic factors alone may not determine the size of offspring that mothers produce...
  94. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
    ..Evolutionary conservation has thus been accompanied by synergy, redundancy, and functional differentiation between DILPs, and these features may themselves be of evolutionary advantage...
  95. pmc Can eggs in a cavity be a female secondary sexual signal? Male nest visits and modelling of egg visual discrimination in blue tits
    Marie Jeanne Holveck
    Centre d Ecologie Fonctionnelle et Evolutive, CEFE CNRS, Montpellier, France
    Biol Lett 6:453-7. 2010
    ..Consequently, we need a better understanding of underlying visual mechanisms in dim-light environments and behavioural discrimination experiments before confirming the signalling potential of eggshell coloration...
  96. ncbi Species-specific responses of pine sesquiterpene synthases to sawfly oviposition
    Diana Köpke
    Max Planck Institute for Chemical Ecology, Beutenberg Campus, Jena, Germany
    Phytochemistry 71:909-17. 2010
    ..More research on this experimental system is required to determine the role of oviposition-induced sesquiterpenes in attracting egg parasitoids and the role of sesquiterpene synthases in regulating sesquiterpene formation...
  97. ncbi Effects of illegal harvest of eggs on the population decline of leatherback turtles in Las Baulas Marine National Park, Costa Rica
    Pilar Santidrian Tomillo
    Department of Bioscience and Biotechnology, Drexel University, Philadelphia, PA 19104, USA
    Conserv Biol 22:1216-24. 2008
    ..Therefore, protection of the beach habitat and nests must be continued and fishery bycatch must be reduced to save this population...
  98. ncbi Drosophila eggshell is patterned by sequential action of feedforward and feedback loops
    Nir Yakoby
    Department of Chemical Engineering and Lewis Sigler Institute for Integrative Genomics, Princeton University, NJ 08544, USA
    Development 135:343-51. 2008
    ..This mechanism demonstrates how complex patterns of gene expression can emerge from simple inputs, through the interaction of regulatory network motifs...
  99. ncbi Periodic cooling of bird eggs reduces embryonic growth efficiency
    Christopher R Olson
    Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, IA 50011, USA
    Physiol Biochem Zool 79:927-36. 2006
    ..This reduction in embryo growth efficiency adds a new dimension to the fitness consequences of variation in adult nest attentiveness...
  100. pmc The modelling of avian visual perception predicts behavioural rejection responses to foreign egg colours
    Phillip Cassey
    School of Biosciences, Birmingham University, Birmingham B15 2TT, UK
    Biol Lett 4:515-7. 2008
    ..Biologically realistic sensory models provide an important tool for relating variability of behavioural responses to perceived phenotypic variation...
  101. ncbi Activity of the nematophagous fungi Pochonia chlamydosporia, Duddingtonia flagrans and Monacrosporium thaumasium on egg capsules of Dipylidium caninum
    Juliana Milani Araujo
    Departamento de Veterinaria, Universidade Federal de Vicosa, Vicosa MG, PH Holfs S N, Cep 3657000, Brazil
    Vet Parasitol 166:86-9. 2009
    ..The results demonstrated that P. chlamydosporia was in vitro effective against capsules and eggs of D. caninum, and can be considered as a potential biological control agent for this helminth...

Research Grants78

  1. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..As a future independent investigator, this system will enable me to collaborate with scientists and clinicians to address a wide scope of challenges in medicine. ..
  2. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..By establishing the role of neurotrophins in airway narrowing with or without inflammation, the proposed studies will the foundation for better understanding of airway diseases, and potential development of new therapeutic targets. ..
  3. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..If we are correct, then our drug therapies should improve blood vessel function and decrease airway resistance in SCD mice with experimental asthma. ..
  4. CTL response to AAV Vector
    Richard J Samulski; Fiscal Year: 2013
    ....
  5. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..As well as other chronic inflammatory diseases (rheumatoid arthritis, lupus, etc.), I hypothesize that HIF-11 inhibition may offer an exciting strategy for the management of asthma. ..
  6. Site-directed Chemotherapy for Breast Cancer using Novel Angiogenesis Inhibitor
    Shaker A Mousa; Fiscal Year: 2010
    ..A novel technology, the use of nanoparticles to encapsulate the test drugs, and direct them to tumors will be tested to determine whether these nanoparticles can improve the delivery of drugs and minimize the associated toxicities. ..
  7. ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMA
    Kwang Chul Kim; Fiscal Year: 2010
    ..In this project, we will try to understand the mechanism at the cellular and molecular level. Successful completion of this project will shed valuable insights in our understanding of the development of asthma. ..
  8. Validation of Novel Infertility Biomarker
    PETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012
    ..Annually, more than 135,000 infertile couples are treated for infertility in US clinics, where the treatment-decision making still relies on outdated, highly subjective light microscopic method of semen evaluation. ..
  9. Functional Analysis of the Embryonic Epigenome in a Non-rodent Model
    Mark E Westhusin; Fiscal Year: 2013
    ....
  10. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..abstract_text> ..
  11. Immunobiology of Acute Environmental Asthma
    David B Peden; Fiscal Year: 2013
    ..2) To study the relevance of cryopyrin and a cryopyrin-adaptor (ASC) in asthma. (3) To study and identify factors which modulate the nucleotide-binding properties and ATPase function of Monarch-1 and cryopyrin. ..
  12. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..This may advance the understanding of mind-body interaction and lead to the development of new strategies of interventions to improve the treatment of mental disorders in chronically ill patients. ..
  13. Predictive Toxicological Paradigms to Establish Inhalation Toxicology Models
    ANDRE ELIAS NEL; Fiscal Year: 2010
    ..The goal of this project is to develop reliable and reproducible protocols that can be used by academic centers, industry and government agencies as a screen for nanomaterial safety. ..
  14. CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
    Stephen W Chensue; Fiscal Year: 2013
    ..The studies proposed will aid the design of improved approaches to vaccine development and therapies to control chronic destructive inflammatory responses. ..
  15. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..The cellular and molecular processes occurring within the primate follicle resulting in the release of a mature ovum (ovulation) that fertilizes and undergoes subsequent embryonic development are incompletely defined...
  16. Role of cannabinoid 2 receptors in B lymphocyte function
    Catherine E Patterson; Fiscal Year: 2010
    ..Also, CB2 mRNA expression will be analyzed in stimulated B cell cultures by RT coupled with real time PCR;expression of overlapping transcription factors will be studied by commercially available gene array kits. ..
  17. Rho Kinase and Airway Hyperresponsiveness
    Stephanie A Shore; Fiscal Year: 2013
    ..Thus, the ROCK pathway may be an important and still relatively unexplored therapeutic target in asthma. Understanding the role of ROCKs in mouse models of asthma could lead to new strategies for preventing this disease. ..
  18. PARTICIPATION OF PARP-1 IN THE PATHOGENESIS OF ASTHMA
    Hamid Boulares; Fiscal Year: 2013
    ....
  19. MECHANISMS OF THE INDUCTION OF ORAL TOLERANCE
    Howard L Weiner; Fiscal Year: 2013
    ..We will investigate mechanisms to induce regulatory T cells by oral tolerance, which takes advantage of natural protective mechanisms that exist in the gut. ..
  20. Enhancing TB vaccine with gene silencing
    Jinhee Lee; Fiscal Year: 2013
    ....
  21. Dual role of the bradykinin B2 receptor during inflammation
    Bruce L Zuraw; Fiscal Year: 2013
    ..Asthma is a common disease both in the Veterans population as well as in the general population, and these studies should help develop more effective asthma treatments. ..
  22. Immune effector-mediated killing of CNS tumors in the GL261 model of glioblastoma
    DANIELLE RENNER; Fiscal Year: 2013
    ....
  23. Asb2 in CD4+ T cell lineage differentiation and its plasticity
    Xiao Hong Sun; Fiscal Year: 2013
    ..Fresh ideas will likely emerge from these studies that will be o therapeutic value in the contest of immunity and autoimmunity. ..
  24. The Role of Caveolins in Lung Inflammation
    CHRISTINA MARIA PABELICK; Fiscal Year: 2013
    ....
  25. Microinjection Station for Utah Transgenic and Gene Targeting Mouse Core
    SUSAN JENIFER TAMOWSKI; Fiscal Year: 2010
    ..ICSI (intracytoplasmic sperm injection) is used to directly inject immobile sperm into an egg. This procedure is used if normal IVF or AIVF is unsuccessful. It is imperative that the injector have excellent optics in this procedure. ..
  26. Targeted genome modification of guinea pig and sheep using engineered zinc finger
    Hilda Holcombe; Fiscal Year: 2011
    ..Furthermore, the streamlined methods will benefit animal welfare by decreasing both the number of animals required to generate genetically-modified animals and the number of major surgical procedures required for their generation. ..
  27. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2012
    ..If these studies succeed, we will have discovered a simple, cheap and safe way to treat allergies. ..
  28. The role of SP-A in Mp-induced exacerbations during allergic airway disease.
    JULIE GUNNELLS LEDFORD; Fiscal Year: 2013
    ....
  29. The role of lymphatic contraction in inflammation and cancer metastasis
    Shan Liao; Fiscal Year: 2013
    ..These studies will provide novel insights into the mechanisms of lymphatic malfunction and identify targets for improving immune protection during edema, autoimmune diseases, infectious diseases and cancer metastasis. ..
  30. Effect of a viral replicon adjuvant on dendritic cell activity
    DANIEL TONKIN; Fiscal Year: 2010
    ..Such findings can potentially be applied to any vaccine target, enabling the development of more effective vaccines. ..
  31. The developing intestinal immune system in Yersinia enterocolitica infection
    REBECCA D ADKINS; Fiscal Year: 2010
    ....
  32. Photo-inactivation of Leishmania for safe and effective delivery of surrogate vac
    Kwang Poo Chang; Fiscal Year: 2013
    ..Completion of the proposed studies is thus expected to produce a final version of these carriers optimal for photodynamic immuno-therapy &-prophylaxis not only against leishmaniasis but also other infectious/non-infectious diseases. ..
  33. Role of the Prolyl Isomerase Pin1 in the Development and Treatment of Asthma
    Kun Ping Lu; Fiscal Year: 2013
    ..These studies would uncover a novel mechanism in asthma development, and also could lead to more effective therapies because Pin1 inhibitors, especially when inhaled, might inhibit multiple targets in different cells in asthma. ..
  34. Immune Cell Carriers for the Delivery of Oncolytic Viruses to Metastatic Tumors
    Richard G Vile; Fiscal Year: 2013
    ..If successful, they will lead to the development of additional clinical trials to test both the safety, and efficacy, of this approach as a novel form of cancer treatment. ..
  35. HuR in Allergic Asthma
    Ulus Atasoy; Fiscal Year: 2012
    ..This would greatly aid in our understanding of disease pathogenesis and treatment and have a direct impact on public health. PHS 398/2590 (Rev. 09/04) Page 15 Continuation Format Page ..
  36. Mucosal Mechanisms Linking Pulmonary and Gastrointestinal Inflammation/Immunity
    Gary B Huffnagle; Fiscal Year: 2010
    ..This information will be critically useful for the future design of therapies to treat or prevent allergic diseases. ..
  37. REGULATION OF NEONATAL IMMUNITY
    Habib Zaghouani; Fiscal Year: 2010
    ..Understanding the function of the neonatal immune system could facilitate development of strategies to balance Th1 and Th2 responses and overcome the susceptibility of the neonate to allergic reactions and microbial infections. ..
  38. Transgenerational Susceptibility to Asthma from Air Pollution Exposure
    Lester Kobzik; Fiscal Year: 2013
    ..Significance: The project will determine if transgenerational inheritance of asthma susceptibility occurs, and lays the foundation for better mechanistic analysis of persistence or resolution of pregnancy exposure effects. ..
  39. Immunomodulatory effects of intestinal helminthes on mucosal immunity
    Hai Ning Shi; Fiscal Year: 2013
    ....
  40. Understanding Protective Immunoregulatory Mechanisms in the Infant Lung
    Prabir Ray; Fiscal Year: 2013
    ..Aim 3. Examine the ability of aerosolized liposome-encapsulated ATRA to restore Treg function and airway tolerance in virus-infected lungs of mice and non-human primates. ..
  41. Viral Infection and Impairment of Immune Tolerance
    Prabir Ray; Fiscal Year: 2012
    ..Aim 3. Examine the ability of aerosolized liposome-encapsulated ATRA to restore Treg function and airway tolerance in RSV-infected lungs. ..
  42. Role of Regulatory CD8 T Cells in Murine Asthma
    Roger S Thrall; Fiscal Year: 2013
    ..co-localization and trafficking using confocal microscopy and chemokine influence. Aim 2. Dependence of LIT on CD8+ T cells and the MHC I CD94/NKG2A - Qa-1 signaling system - in vivo and in vitro approaches. ..
  43. Targeted genome modification of guinea pig and sheep using engineered zinc finger
    Hilda Holcombe; Fiscal Year: 2012
    ..abstract_text> ..
  44. Role of breast milk in development of neonatal oral tolerance to foods
    KIRSI JARVINEN-SEPPO; Fiscal Year: 2013
    ..NARRATIVE: This research aims to solve a health concern of great public interest: should breastfeeding mothers avoid or eat potential food allergens in order to avoid development of food allergy in their children. ..
  45. Novel Costimulation Blockers in Islet Transplantation
    Scott M Krummey; Fiscal Year: 2013
    ....
  46. Role of STARD6 in ovarian steroidogenesis
    HOLLY ANNE LAVOIE; Fiscal Year: 2013
    ..In addition to preparation of the ovum for ovulation, another critical function of the ovary is de novo steroid synthesis from cholesterol De novo ..
  47. Mucosal Therapy for Autoimmunity
    David W Pascual; Fiscal Year: 2013
    ..Thus, once we are able to establish the ps1 delivery technology, we will move forward to use current models for Sj"gren's Syndrome to test if disease progression can be reduced. ..
  48. Immunomodulation of Vagal Innervation in the Respiratory Tract
    LETITIA ALEXIS WEIGAND; Fiscal Year: 2012
    ....
  49. Kupffer Cells in Liver Immunopathology
    Ian Nicholas Crispe; Fiscal Year: 2010
    ..These experiments will shed light on how KCs affect CTL-dependent immune responses in the liver and may clarify the mechanism through which hepatotrophic pathogens such as HCV evade immune clearance and establish chronic infections. ..
  50. Neisserial Porins and Antigen Presenting Cells
    LEE MARK WETZLER; Fiscal Year: 2013
    ..Moreover, we shall further examine the mechanism of PorB adjuvant activity via the use of MyD88 floxed mice bred with mice expressing cell specific cre recombinase. ..
  51. Immunomodulation of Relapsing Remitting Multiple Sclerosis by Gut Parasites
    Zsuzsanna Fabry; Fiscal Year: 2010
    ..This knowledge will lead to a better understanding of the mechanisms of HINT immunomodulatory intervention in RRMS, and open up the possibility of expanding this approach to other autoimmune diseases. ..
  52. Validation in Transgenic Animal Models of Clinical Correlates of IC/PBS
    Yi Luo; Fiscal Year: 2013
    ..A valid animal model is critical for better understanding of the mechanisms behind IC/PBS and for developing effective interventions for this refractory human disease. ..
  53. Novel Mechanisms of Smooth Muscle Beta2-receptor Regulation Relevant to Asthma
    Deepak A Deshpande; Fiscal Year: 2013
    ..Taken together, these proposed studies will combine molecular, cellular and transgenic approaches to define mechanisms of [unreadable]2AR function and regulation relevant to asthma. ..
  54. The Effect of Bromelain on CD4+ T Cell Function in Asthma
    ERIC RICHARD SECOR; Fiscal Year: 2012
    ..These studies will help elucidate the anti-inflammatory mechanism(s) of action of Br and provide rigorous advanced training to a CAM clinician, all of which are directly relevant to the mission of NCCAM. ..
  55. PlexinD1-regulated intrathymic movement
    Young Il Choi; Fiscal Year: 2012
    ..T cells emanate from the thymus. Hence, understanding of the processes required for normal thymic architecture, differentiation and maturation will contribute to generation of more effective immunity. ..
  56. Prenatal Programming of Neonatal Asthma Susceptibility
    Lester Kobzik; Fiscal Year: 2013
    ..abstract_text> ..
  57. Impact of Highly Active T Lymphocytes from Induced Pluripotent Stem Cells
    Jianxun Song; Fiscal Year: 2012
    ....
  58. IL-13 Associated Eosinophil Lung Responses
    Marc E Rothenberg; Fiscal Year: 2013
    ..g. anti-cytokines agents) that are currently being developed for the treatment of asthma;thus, helping to clarify the unique and comparative effects of interrupting IL-4, IL-13 and/or their receptors in asthma. ..
  59. Engineered lipid vesicles as potent vaccine vectors for HIV
    Darrell J Irvine; Fiscal Year: 2013
    ....
  60. Entry of antigen-presenting B cells into the follicle directed by IFNa and IL-17
    Hui Chen Hsu; Fiscal Year: 2013
    ....
  61. Design and Development of Pharmacotherapies for Treating Stimulant Abuse
    Frank Ivy Carroll; Fiscal Year: 2010
    ..3) To continue on a limited basis our development of selected 3-phenyltropane analogs as second-generation pharmacotherapies to treat cocaine addiction. ..
  62. The Role of DC's Tolerance
    Shoshana Katzman; Fiscal Year: 2010
    ..immunity. How this balance is maintained and what causes disregulation, resulting in autoimmunity, is a vital question in immunology today, and integral for the design of therapies in the future. ..
  63. NEUROCHEMICALS IN HYPOTHALAMIC SIGNALING AFTER COITUS
    K Y Pau; Fiscal Year: 2000
    ..Aim 3b will determine if electrical lesions of the nPGi and/or nPH prevent either the postcoital expression of LC cFos protein, TH/NET mRNAs or the LH surge. These studies may provide information on neurologically related infertility. ..
  64. ACROSOMAL ENZYMES AND THEIR ROLE IN FERTILIZATION
    PRAKASH SRIVASTAVA; Fiscal Year: 1993
    The ovum is surrounded by the cumulus, the corona, the zona and vitelline membrane. Capacitated rabbit sperm undergo the acrosome reaction during the passage through the cumulus...
  65. CELLULAR AND MOLECULAR MECHANISMS FOR MUCOSAL IMMUNITY
    Kohtaro Fujihashi; Fiscal Year: 2005
    ..The seminal findings which have emanated from this grant effort since 1982 will again remain focused on the cellular and molecular events required for induction of mucosal immunity or oral tolerance in the GI tract. ..
  66. A THECAL ROLE IN OVULATION
    KATHERINE ROBY; Fiscal Year: 1999
    ..The studies outlined in this proposal begin to assess the mechanism whereby TCDD blocks ovulation. ..
  67. PAF AND PRE-IMPLANTATION/IMPLANTATION PHENOMENA
    Michael Harper; Fiscal Year: 1991
    ..PAF and the use of PAF inhibitors to block this response, 5) examine the relevance of embryoderived PAF for the ovum transport and implantation process by means of embryo transfer techniques following treatment of the embryos with ..
  68. REGULATION AND FUNCTION OF HEAT SHOCK FACTORS IN TESTIS
    KEVIN SARGE; Fiscal Year: 1999
    ..of distinct spermatogenic cell types, are transformed into mature spermatozoa capable of fertilizing an ovum. Each spermatogenic cell type displays unique patterns of gene expression which ensure the production of proteins ..
  69. MEMBRANE RECEPTOR TRAFFICKING AND ANTIGEN PROCESSING
    Richard Mitchell; Fiscal Year: 1999
    ....
  70. IMMUNOBIOLOGICAL ROLE OF FERTILIZATION ANTIGEN (FA-1)
    RAJESH NAZ; Fiscal Year: 1993
    ....
  71. Model Vaccines Exploiting Fungal Mannosylation
    STUART LEVITZ; Fiscal Year: 2009
    ....
  72. Immunodeficiency and Autoimmunity
    ABUL ABBAS; Fiscal Year: 2009
    ..This project will provide valuable information about why immune deficiencies are associated with autoimmunity, and may give insights into the general mechanisms of failure of tolerance and development of systemic autoimmunity. ..
  73. Peritumorally transformable nanoparticles for intraperitoneal chemotherapy of ova
    Yoon Yeo; Fiscal Year: 2010
    ....
  74. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  75. HORMONAL CONTROL OF OVIDUCTAL SECRETORY PROTEINS
    WILLIAM BUHI; Fiscal Year: 1991
    ..These studies may identify and define mechanisms and controls for fertilization and embryonic development...
  76. Triggering intestinal inflammation
    Hai Shi; Fiscal Year: 2005
    ....
  77. Mechanism of basophil mediated immune modulation
    Booki Min; Fiscal Year: 2010
    ..The results may allow us to better understand in vivo roles of these rare yet potent cells and to develop novel strategies to prevent basophil mediated pathology often found in allergic inflammations such as asthma. ..
  78. ANTIGEN IMMUNOSUPPRESSION BY KILLER LANGERHANS CELLS
    Akira Takashima; Fiscal Year: 2004
    ..g., haptens, allergens, autoantigens, and alloantigens). ..