fetus

Summary

Summary: The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO.

Top Publications

  1. pmc Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis
    Y M Lo
    Department of Chemical Pathology, The University of Hong Kong, Prince Wales Hospital, Shatin, New Territories, Hong Kong
    Am J Hum Genet 62:768-75. 1998
  2. ncbi Innate immunity of the newborn: basic mechanisms and clinical correlates
    Ofer Levy
    Department of Medicine, Division of Infectious Diseases, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Nat Rev Immunol 7:379-90. 2007
  3. pmc Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
    Carrie E McCurdy
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Invest 119:323-35. 2009
  4. pmc Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing
    Eric Z Chen
    Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e21791. 2011
  5. ncbi Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review
    Bea R H Van den Bergh
    Department of Developmental Psychology, Catholic University of Leuven KULeuven, Tiensestraat 102, 3000 Leuven, Belgium
    Neurosci Biobehav Rev 29:237-58. 2005
  6. ncbi Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity
    Jerrold J Heindel
    Division of Extramural Research and Training, National Institute of Environmental Health Sciences, NIH DHHS, Cellular, Organs and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA
    Mol Cell Endocrinol 304:90-6. 2009
  7. pmc Tracheal dimensions in human fetuses: an anatomical, digital and statistical study
    Michał Szpinda
    Department of Normal Anatomy, The Ludwik Rydygier Collegium Medicum, Karłowicza 24 Street, 85 092 Bydgoszcz, Poland
    Surg Radiol Anat 34:317-23. 2012
  8. ncbi A balancing act: mechanisms by which the fetus avoids rejection by the maternal immune system
    J C Warning
    Department of Perinatal Research, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, Sydney, New South Wales 2065, Australia
    Reproduction 141:715-24. 2011
  9. pmc Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus
    Ute M Schaefer-Graf
    Department of Obstetrics, Vivantes Medical Center Berlin Neukoelln, Berlin, Germany
    Diabetes Care 31:1858-63. 2008
  10. ncbi Compensatory renal growth after unilateral nephrectomy in the ovine fetus
    Rebecca Douglas-Denton
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia
    J Am Soc Nephrol 13:406-10. 2002

Detail Information

Publications349 found, 100 shown here

  1. pmc Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis
    Y M Lo
    Department of Chemical Pathology, The University of Hong Kong, Prince Wales Hospital, Shatin, New Territories, Hong Kong
    Am J Hum Genet 62:768-75. 1998
    ..These data suggest that fetal DNA can be readily detected in maternal plasma and serum and may be a valuable source of material for noninvasive prenatal diagnosis...
  2. ncbi Innate immunity of the newborn: basic mechanisms and clinical correlates
    Ofer Levy
    Department of Medicine, Division of Infectious Diseases, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Nat Rev Immunol 7:379-90. 2007
    The fetus and newborn face a complex set of immunological demands, including protection against infection, avoidance of harmful inflammatory immune responses that can lead to pre-term delivery, and balancing the transition from a sterile ..
  3. pmc Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
    Carrie E McCurdy
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Invest 119:323-35. 2009
    ..These results suggest that a developing fetus is highly vulnerable to excess lipids, independent of maternal diabetes and/or obesity, and that exposure to this ..
  4. pmc Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing
    Eric Z Chen
    Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e21791. 2011
    ..We studied 392 pregnancies, among which 25 involved a trisomy 13 fetus and 37 involved a trisomy 18 fetus, by massively parallel sequencing...
  5. ncbi Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review
    Bea R H Van den Bergh
    Department of Developmental Psychology, Catholic University of Leuven KULeuven, Tiensestraat 102, 3000 Leuven, Belgium
    Neurosci Biobehav Rev 29:237-58. 2005
    ..Cortisol appears to cross the placenta and thus may affect the fetus and disturb ongoing developmental processes...
  6. ncbi Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity
    Jerrold J Heindel
    Division of Extramural Research and Training, National Institute of Environmental Health Sciences, NIH DHHS, Cellular, Organs and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA
    Mol Cell Endocrinol 304:90-6. 2009
    ..Eliminating exposures to these chemicals and improving nutrition during development offer the potential for reducing obesity and associated diseases...
  7. pmc Tracheal dimensions in human fetuses: an anatomical, digital and statistical study
    Michał Szpinda
    Department of Normal Anatomy, The Ludwik Rydygier Collegium Medicum, Karłowicza 24 Street, 85 092 Bydgoszcz, Poland
    Surg Radiol Anat 34:317-23. 2012
    ..The present study was performed to compile normative data for external dimensions of the trachea at varying gestational age...
  8. ncbi A balancing act: mechanisms by which the fetus avoids rejection by the maternal immune system
    J C Warning
    Department of Perinatal Research, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, Sydney, New South Wales 2065, Australia
    Reproduction 141:715-24. 2011
    Successful pregnancy requires strict temporal regulation of maternal immune function to accommodate the growing fetus. Early implantation is facilitated by inflammatory processes that ensure adequate vascular remodeling and placental ..
  9. pmc Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus
    Ute M Schaefer-Graf
    Department of Obstetrics, Vivantes Medical Center Berlin Neukoelln, Berlin, Germany
    Diabetes Care 31:1858-63. 2008
    ..To determine the contribution of maternal glucose and lipids to intrauterine metabolic environment and fetal growth in pregnancies with gestational diabetes mellitus (GDM)...
  10. ncbi Compensatory renal growth after unilateral nephrectomy in the ovine fetus
    Rebecca Douglas-Denton
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia
    J Am Soc Nephrol 13:406-10. 2002
    ..After 27 to 34 d, ewes and fetuses were killed and the right kidney of each fetus was removed and weighed...
  11. ncbi Optimal detection of fetal chromosomal abnormalities by massively parallel DNA sequencing of cell-free fetal DNA from maternal blood
    Amy J Sehnert
    Verinata Health, Inc, San Carlos, CA, USA
    Clin Chem 57:1042-9. 2011
    ..Although existing algorithms focus on the detection of fetal trisomy 21 (T21), these same algorithms have difficulty detecting trisomy 18 (T18)...
  12. pmc Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma
    Rossa W K Chiu
    Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Proc Natl Acad Sci U S A 105:20458-63. 2008
    ..Massively parallel plasma DNA sequencing represents a new approach that is potentially applicable to all pregnancies for the noninvasive prenatal diagnosis of fetal chromosomal aneuploidies...
  13. ncbi Early fetal development of the human cerebellum
    Kwang Ho Cho
    Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, 344 2 Sinyong dong, Iksan, Jeonbuk, Korea
    Surg Radiol Anat 33:523-30. 2011
    ..Consequently, in the early stages, it appears that the cerebellar hemisphere and vermis develop independently of each other...
  14. ncbi FGF9 suppresses meiosis and promotes male germ cell fate in mice
    Josephine Bowles
    Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Dev Cell 19:440-9. 2010
    ....
  15. ncbi CD34-positive developing vessels and other structures in human fetuses: an immunohistochemical study
    Shin Ichi Abe
    Oral Health Science Center hrc8, Tokyo Dental College, Chiba, Japan
    Surg Radiol Anat 33:919-27. 2011
    ..However, to our knowledge, the in situ distribution of CD34-positive cells has not yet been described in the human fetus, with the exception of a few organs...
  16. pmc Implementing prenatal diagnosis based on cell-free fetal DNA: accurate identification of factors affecting fetal DNA yield
    Angela N Barrett
    NE Thames Regional Molecular Genetics Laboratories, Great Ormond Street Hospital for Children, London, United Kingdom
    PLoS ONE 6:e25202. 2011
    ....
  17. ncbi In utero surgery - current state of the art: part I
    Piotr Wojcicki
    Department of Plastic Surgery, Wroclaw Medical University, Polanica Zdrój, Poland
    Med Sci Monit 16:RA237-44. 2010
    ..in the course of intrauterine life dates back to 1963, when Lilly performed first blood transfusion in the fetus. Ever since then, it has been introduced as treatment option in series of lethal malformations...
  18. pmc B-1 B cell development in the fetus and adult
    Encarnacion Montecino-Rodriguez
    Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Immunity 36:13-21. 2012
    ..these schemes are too simplistic and that the lymphoid potential of HSCs and precursors arising in the embryo, fetus, neonate, and adult is remarkably distinct...
  19. ncbi Accumulation of cadmium in human placenta interacts with the transport of micronutrients to the fetus
    Maria Kippler
    Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden
    Toxicol Lett 192:162-8. 2010
    ..to what extent the accumulation of Cd in human placenta interacts with the transport of micronutrients to the fetus. Cd and micronutrients were measured in placenta and umbilical cord blood from 44 non-smoking, rural Bangladeshi ..
  20. ncbi Regulatory T cells mediate maternal tolerance to the fetus
    Varuna R Aluvihare
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Nat Immunol 5:266-71. 2004
    ..function in suppressing autoimmune responses, maternal regulatory T cells suppressed an aggressive allogeneic response directed against the fetus. Their absence led to a failure of gestation due to immunological rejection of the fetus.
  21. pmc Selective analysis of cell-free DNA in maternal blood for evaluation of fetal trisomy
    Andrew B Sparks
    Aria Diagnostics Inc, 5945 Optical Court, San Jose, CA 95138, USA
    Prenat Diagn 32:3-9. 2012
    ..To develop a novel prenatal assay based on selective analysis of cell-free DNA in maternal blood for evaluation of fetal Trisomy 21 (T21) and Trisomy 18 (T18)...
  22. pmc Fetal-specific DNA methylation ratio permits noninvasive prenatal diagnosis of trisomy 21
    Elisavet A Papageorgiou
    Cytogenetics and Genomics Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Nat Med 17:510-3. 2011
    ..Extensive investigation of methylation differences between the mother and the fetus has led to the identification of differentially methylated regions (DMRs)...
  23. ncbi Axonal development in the cerebral white matter of the human fetus and infant
    Robin L Haynes
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 484:156-67. 2005
    ..These data suggest that immature axons are susceptible to damage in PVL and that the timing of axonal maturation must be considered toward establishing its pathology relative to the oligodendrocyte/myelin/axonal unit...
  24. pmc Endochondral ossification is required for haematopoietic stem-cell niche formation
    Charles K F Chan
    Department of Pathology, Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA
    Nature 457:490-4. 2009
    ..Collectively, our data implicate endochondral ossification, bone formation that proceeds through a cartilage intermediate, as a requirement for adult HSC niche formation...
  25. ncbi Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds
    Hayley M Scott
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Endocr Rev 30:883-925. 2009
    ..testis of humans and of rodents and its susceptibility to disruption; where there is limited information for the fetus, evidence from effects on steroidogenesis in the adult testis is considered...
  26. ncbi Role of insulin-like growth factors in embryonic and postnatal growth
    J Baker
    Department of Genetics and Development, Columbia University, New York, New York 10032
    Cell 75:73-82. 1993
    ....
  27. ncbi Maternal nutrition and fetal development
    Guoyao Wu
    Department of Animal Science, Texas A and M University, Health Science Center, College Station, TX 77843, USA
    J Nutr 134:2169-72. 2004
    ..Promoting optimal nutrition will not only ensure optimal fetal development, but will also reduce the risk of chronic diseases in adults...
  28. pmc Quantitative anatomy of the growing abdominal aorta in human fetuses: an anatomical, digital and statistical study
    Michał Szpinda
    Department of Normal Anatomy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland
    Med Sci Monit 18:BR419-26. 2012
    ..Advances in perinatal medicine have required an extensive knowledge of fetal aorto-iliac measurements. The present study was performed to compile reference data for dimensions of the abdominal aorta at varying gestational ages...
  29. ncbi Detection of microdeletion 22q11.2 in a fetus by next-generation sequencing of maternal plasma
    Taylor J Jensen
    Sequenom Center for Molecular Medicine, San Diego, CA, USA
    Clin Chem 58:1148-51. 2012
    ..We examined a clinically relevant genomic region, chromosome 22q11.2, the location of a series of well-characterized deletion anomalies that cause 22q11.2 deletion syndrome...
  30. ncbi Genomic analysis of fetal nucleic acids in maternal blood
    Yuk Ming Dennis Lo
    Li Ka Shing Institute of Health Sciences and Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Annu Rev Genomics Hum Genet 13:285-306. 2012
    ..have detected a chromosomal translocation and a microdeletion and have deduced a genome-wide genetic map of a fetus from maternal plasma...
  31. pmc Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero
    Jeff E Mold
    Division of Experimental Medicine, Department of Medicine, University of California at San Francisco UCSF, San Francisco, CA 94110, USA
    Science 322:1562-5. 2008
    ..These findings reveal a form of antigen-specific tolerance in humans, induced in utero and probably active in regulating immune responses after birth...
  32. pmc Non-invasive prenatal measurement of the fetal genome
    H Christina Fan
    Department of Bioengineering, Stanford University, Clark Center Rm E300, 318 Campus Drive, Stanford, California 94305, USA
    Nature 487:320-4. 2012
    The vast majority of prenatal genetic testing requires invasive sampling. However, this poses a risk to the fetus, so one must make a decision that weighs the desire for genetic information against the risk of an adverse outcome due to ..
  33. ncbi Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus
    Vanessa E Murphy
    Mothers and Babies Research Centre, and Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia
    Endocr Rev 27:141-69. 2006
    The environment in which the fetus develops is critical for its survival and long-term health. The regulation of normal human fetal growth involves many multidirectional interactions between the mother, placenta, and fetus...
  34. ncbi Regulation of the pulmonary circulation in the fetus and newborn
    Yuansheng Gao
    Department of Physiology and Pathophysiology, Peking University, Health Science Center, Beijing, China
    Physiol Rev 90:1291-335. 2010
    During the development of the pulmonary vasculature in the fetus, many structural and functional changes occur to prepare the lung for the transition to air breathing...
  35. ncbi Targeted massively parallel sequencing of maternal plasma DNA permits efficient and unbiased detection of fetal alleles
    Gary J W Liao
    Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Clin Chem 57:92-101. 2011
    ..In this study, we investigated its applicability in enriching selected genomic regions from plasma DNA and the quantitative performance of this approach...
  36. ncbi Fetal tolerance in human pregnancy--a crucial balance between acceptance and limitation of trophoblast invasion
    Ulrike von Rango
    Department of Anatomy und Reproductive Biology, Medical School, RWTH University Aachen, Wendlingweg 2, 52074 Aachen, Germany
    Immunol Lett 115:21-32. 2008
    ..Together these data suggest that the mother extends her "definition of self" for 9 months on the foreign antigens of the fetus.
  37. pmc Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus
    Kathleen E McGrath
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, Rochester, NY 14642, USA
    Blood 111:2409-17. 2008
    ..Continued studies comparing primitive and definitive erythropoiesis will lead to an improved understanding of terminal erythroid maturation...
  38. ncbi Endogenous estrogens inhibit mouse fetal Leydig cell development via estrogen receptor alpha
    Geraldine Delbes
    Unité de Gamétogenèse et Génotoxicité, Institut National de la Sante et de la Recherche Medicale Unite 566, Commissariat a l Energie Atomique, Universite Paris 7, Denis Diderot, Fontenay aux Roses, France
    Endocrinology 146:2454-61. 2005
    ..Thus, this study shows that endogenous estrogens physiologically inhibit steroidogenesis via ER alpha by acting directly on the testis early in fetal and neonatal development...
  39. pmc Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development
    Dana C Dolinoy
    Department of Radiation Oncology and University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:13056-61. 2007
    ..Thus, we present compelling evidence that early developmental exposure to BPA can change offspring phenotype by stably altering the epigenome, an effect that can be counteracted by maternal dietary supplements...
  40. ncbi Fatty acid supply to the human fetus
    Paul Haggarty
    Nutrition and Epigenetics Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, AB21 9SB, Scotland, United Kingdom
    Annu Rev Nutr 30:237-55. 2010
    Deposition of fat in the fetus increases exponentially with gestational age, reaching its maximal rate-around 7 g/day or 90% of energy deposition-at term...
  41. ncbi Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury
    S A Back
    Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 21:1302-12. 2001
    ....
  42. ncbi Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy
    Tamara Tilburgs
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    J Immunol 180:5737-45. 2008
    ..of a destructive immune response mediated by maternal alloreactive lymphocytes directed against the allogeneic fetus. Murine studies suggest that CD4(+)CD25(+) T cells provide mechanisms of specific immune tolerance to fetal ..
  43. ncbi The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids
    Megan C Holmes
    Endocrinology Unit, Centre for Cardiovascular Disease, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 26:3840-4. 2006
    ..It remains uncertain whether such effects are mediated indirectly via altered maternal function or directly on the fetus and its placenta...
  44. pmc Scarless fetal wound healing: a basic science review
    Barrett J Larson
    Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Plast Reconstr Surg 126:1172-80. 2010
    ..These differences may have important implications in scarless wound repair...
  45. ncbi Chorioamnionitis: a multiorgan disease of the fetus?
    M Gantert
    Department of Obstetrics and Gynecology, Klinikum Osnabruck, Osnabruck, Germany
    J Perinatol 30:S21-30. 2010
    ..phenomenon, including umbilical inflammation and increased serum levels of proinflammatory cytokines in the fetus. Ascending maternal infections frequently lead to systemic fetal inflammatory reaction...
  46. ncbi Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition
    Adam Stevens
    Faculties of Life Sciences and Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PT, UK
    Endocrinology 151:3652-64. 2010
    ..These epigenetic changes in GR and POMC in the hypothalamus may also predispose the offspring to altered regulation of food intake, energy expenditure, and glucose homeostasis later in life...
  47. pmc Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat fetal testis in vitro
    François Chauvigné
    INSERM Institut National de la Santé et de la Recherche Médicale, U625, GERHM, Universite Rennes I, Campus de Beaulieu, Rennes, Bretagne, France
    Environ Health Perspect 117:515-21. 2009
    ..Nevertheless, their path of action, dose-response character, and cellular target(s) within the fetal testis are not known...
  48. pmc Sites of differential DNA methylation between placenta and peripheral blood: molecular markers for noninvasive prenatal diagnosis of aneuploidies
    Elisavet A Papageorgiou
    Cytogenetics and Genomics Department, The CyprusInstitute of Neurology and Genetics, Nicosia, Cyprus
    Am J Pathol 174:1609-18. 2009
    ..In addition, we demonstrated the effectiveness of the methylation DNA immunoprecipitation approach in the enrichment of hypermethylated fetal DNA...
  49. pmc Androgen concentrations in umbilical cord blood and their association with maternal, fetal and obstetric factors
    Jeffrey A Keelan
    School of Women s and Infants Health, King Edward Memorial Hospital, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e42827. 2012
    ..Caution should be exercised when interpreting previously-published data that have not taken all of these factors into account...
  50. pmc Fetal cells in the pregnant mouse are diverse and express a variety of progenitor and differentiated cell markers
    Yutaka Fujiki
    Division of Genetics, Department of Pediatrics, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts 02111, USA
    Biol Reprod 81:26-32. 2009
    ..Future studies will address whether fetal cells cross the placental barrier in a differentiated state or as a homogenous population and subsequently differentiate in target maternal organs...
  51. pmc Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability
    Mark J Nijland
    Center for Pregnancy and Newborn Research, University of Texas Health Science Center, San Antonio, TX, USA
    J Physiol 588:1349-59. 2010
    ..In conclusion, these are the first data from a fetal non-human primate indicating hypomethylation of the PCK1 promoter in the liver following moderate maternal nutrient reduction...
  52. ncbi HLA-G and immune tolerance in pregnancy
    Joan S Hunt
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7400, USA
    FASEB J 19:681-93. 2005
    ....
  53. ncbi Rosiglitazone increases the expression of peroxisome proliferator-activated receptor-gamma target genes in adipose tissue, liver, and skeletal muscle in the sheep fetus in late gestation
    B S Muhlhausler
    Sansom Research Institute, University of South Australia, Adelaide 5000, Australia
    Endocrinology 150:4287-94. 2009
    ....
  54. pmc Fetal inflammatory response and brain injury in the preterm newborn
    Shadi Malaeb
    Division of Newborn Medicine, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Child Neurol 24:1119-26. 2009
    ..Neuroinflammatory injury not only destroys what exists but also changes what develops...
  55. pmc Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice
    Dhivya Haridass
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School and Twincore Centre for Experimental and Clinical Infection Research, Hannover 30625, Germany
    Am J Pathol 175:1483-92. 2009
    ..These results have important implications in the context of selecting the optimal strategy for human liver cell therapies...
  56. pmc High resolution size analysis of fetal DNA in the urine of pregnant women by paired-end massively parallel sequencing
    Nancy B Y Tsui
    Centre for Research into Circulating Fetal Nucleic Acids, Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    PLoS ONE 7:e48319. 2012
    ..However, the existence of fetal DNA in maternal urine has remained controversial. The issue is due to the lack of appropriate technology to robustly detect the potentially highly degraded fetal DNA in maternal urine...
  57. ncbi Mechanisms of T cell tolerance towards the allogeneic fetus
    Adrian Erlebacher
    Department of Pathology and NYU Cancer Institute, NYU School of Medicine, Langone Medical Center, 550 First Avenue, New York, New York 10016, USA
    Nat Rev Immunol 13:23-33. 2013
    ..fetal or placental specificity, or minimize the possibility that such T cells, if activated, are able to harm the fetus. The T cell response to antigens expressed by the conceptus serves as a paradigm for the study of tissue-specific ..
  58. ncbi Differential maturation of the innate immune response in human fetuses
    Tobias Strunk
    Department of Pediatrics, University of Lubeck, Medical School, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Pediatr Res 56:219-26. 2004
    ..The results of our study add significantly to our understanding of the maturation and impairment of the innate immune response...
  59. ncbi Maternal lipid metabolism and placental lipid transfer
    E Herrera
    Department of Biochemistry, Molecular and Cellular Biology, University San Pablo CEU, Madrid, Spain
    Horm Res 65:59-64. 2006
    ..present in smaller proportions, maternal plasma non-esterified fatty acids are also a source of LC-PUFA for the fetus, their placental transfer being facilitated by the presence of a membrane fatty acid-binding protein...
  60. pmc Fetal liver blood flow distribution: role in human developmental strategy to prioritize fat deposition versus brain development
    Keith M Godfrey
    Institute of Developmental Sciences, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
    PLoS ONE 7:e41759. 2012
    ..If placental nutrient supply is limited, the fetus faces a dilemma: should resources be allocated to brain growth, or to fat deposition for use as a potential ..
  61. ncbi Gluconeogenesis in the fetus and neonate
    S Kalhan
    Department of Pediatrics, Robert Schwartz M D Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    Semin Perinatol 24:94-106. 2000
    ..The developmental expression of GNG in the fetus and newborn and the quantitative contribution of GNG to glucose has been extensively investigated in humans and ..
  62. ncbi Gestational age and maternal weight effects on fetal cell-free DNA in maternal plasma
    Eric Wang
    Ariosa Diagnostics, San Jose, CA, USA
    Prenat Diagn 33:662-6. 2013
    ..To determine the effects of gestational age and maternal weight on percent fetal cell-free DNA (cfDNA) in maternal plasma and the change in fetal cfDNA amounts within the same patient over time...
  63. ncbi Nicotine replacement therapy effect on pregnancy outcomes
    Alicia B Forinash
    Department of Pharmacy Practice, St Louis College of Pharmacy, MO, USA
    Ann Pharmacother 44:1817-21. 2010
    ..To review data assessing the effects of nicotine replacement therapy (NRT) during pregnancy on fetal, neonatal, and maternal outcomes...
  64. pmc Insufficient maintenance DNA methylation is associated with abnormal embryonic development
    Li jun Yin
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang 310006, China
    BMC Med 10:26. 2012
    ..Abnormal function of these DNMTs may have serious consequences for embryonic development...
  65. pmc Pulmonary and systemic inflammatory responses to intra-amniotic IL-1α in fetal sheep
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Univ of Cincinnati, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 301:L285-95. 2011
    ..IL-1α is a potent mediator of the fetal inflammatory response syndrome...
  66. ncbi Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy
    Graham J Burton
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    J Clin Endocrinol Metab 87:2954-9. 2002
    Providing adequate nutrition to the fetus is key to a successful pregnancy...
  67. pmc Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate
    B Orr
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh, UK
    Oncogene 31:1130-42. 2012
    ..Additionally, two molecules (ASPN and STC1) marked overlapping and distinct subregions of stroma associated with tumour epithelia and may represent new CAF markers...
  68. ncbi Role of the placenta in regulation of fetal iron status
    Harry J McArdle
    Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen, United Kingdom
    Nutr Rev 69:S17-22. 2011
    During pregnancy, the developing fetus is entirely dependent on its mother for nutrition and waste disposal, which take place almost exclusively across the placenta...
  69. ncbi Review: Transport of maternal cholesterol to the fetal circulation
    L A Woollett
    University of Cincinnati, Metabolic Diseases Institute, Department of Pathology, Cincinnati, OH 45236 507, USA
    Placenta 32:S218-21. 2011
    ..in humans, rodents, and cell culture demonstrate that circulating maternal cholesterol can be transported to the fetus. The two major cell types responsible for the transport are trophoblasts and endothelial cells of the ..
  70. ncbi Effect of cerebral hypothermia and asphyxia on the subventricular zone and white matter tracts in preterm fetal sheep
    Robert Daniel Barrett
    Department of Physiology, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Brain Res 1469:35-42. 2012
    ..Although white matter protection with cerebral hypothermia was associated with reduced proliferation in the white matter tracts, it did not impair proliferation in the SVZ...
  71. ncbi MeDIP real-time qPCR of maternal peripheral blood reliably identifies trisomy 21
    Evdokia Tsaliki
    NIPD Genetics Ltd, Nicosia, Cyprus
    Prenat Diagn 32:996-1001. 2012
    ....
  72. pmc Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
    David V Hansen
    1 Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, USA 2 Department of Neurology, University of California, San Francisco, San Francisco, California, USA 3
    Nat Neurosci 16:1576-87. 2013
    ....
  73. ncbi A method for noninvasive detection of fetal large deletions/duplications by low coverage massively parallel sequencing
    Shengpei Chen
    BGI Shenzhen, Shenzhen, China
    Prenat Diagn 33:584-90. 2013
    ..To report the feasibility of fetal chromosomal deletion/duplication detection using a novel bioinformatic method of low coverage whole genome sequencing of maternal plasma...
  74. pmc Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response
    Devon B Oskvig
    Section on Functional Neuroanatomy, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Brain Behav Immun 26:623-34. 2012
    ..Our results provide a novel mechanism by which MIA induces the widespread down-regulation of critical neurodevelopmental genes, including those previously associated with autism...
  75. pmc Dorsal radial glial cells have the potential to generate cortical interneurons in human but not in mouse brain
    Xiaojing Yu
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 31:2413-20. 2011
    ..Multiple progenitors and sites of cortical interneuron origin in human might be an evolutionary adaptation underlying brain expansion and the increased complexity of cortical circuitry in humans...
  76. pmc Noninvasive detection of fetal subchromosome abnormalities via deep sequencing of maternal plasma
    Anupama Srinivasan
    Verinata Health, Inc, Redwood City, CA 94063, USA
    Am J Hum Genet 92:167-76. 2013
    ..This approach combines the advantage of enhanced fetal genomic resolution with the improved safety of a noninvasive maternal blood test...
  77. ncbi Intergender differences in histological architecture of the fascia pelvis parietalis: a cadaveric study
    Eiji Hirata
    Department of Obstetrics and Gynecology, Hiroshima University, Hiroshima, Japan
    Clin Anat 24:469-77. 2011
    ....
  78. ncbi Placental immunology and maternal alloimmune responses
    B M Kumpel
    Bristol Institute for Transfusion Sciences, NHS Blood and Transplant, Northway, Filton, Bristol, UK
    Vox Sang 102:2-12. 2012
    During pregnancy, women are tolerant of their semi-allogeneic fetus whilst not being immunosuppressed and indeed readily form alloantibodies...
  79. ncbi Gestational atrazine exposure: effects on male reproductive development and metabolite distribution in the dam, fetus, and neonate
    Melanie J P Fraites
    Endocrine Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 32:52-63. 2011
    ..We conclude that, although levels of chlorotriazines within the fetus were considerable, gestational exposures of 1-20mg/kg-d do not lead to alterations in the measures of male ..
  80. ncbi Intrauterine effects of maternal smoking on sensitization, asthma, and chronic obstructive pulmonary disease
    Machteld N Hylkema
    Department of Pathology, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Proc Am Thorac Soc 6:660-2. 2009
    ..Future experimental studies may reveal whether lung developmental changes may additionally underlie susceptibility to the apparent adult-onset disease chronic obstructive pulmonary disease...
  81. ncbi Effects of repeated maternal betamethasone administration on growth and hypothalamic-pituitary-adrenal function of the ovine fetus at term
    D M Sloboda
    Departments of Physiology and Obstetrics and Gynecology, University of Toronto, Toronto M5S 1A8, Canada
    J Endocrinol 165:79-91. 2000
    ....
  82. pmc Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses
    Donna K Slonim
    Department of Computer Science, Tufts University, Medford, MA 02155, USA
    Proc Natl Acad Sci U S A 106:9425-9. 2009
    ..Our results suggest that there are secondary adverse consequences of DS evident in the second trimester, leading to testable hypotheses about possible antenatal therapy for DS...
  83. ncbi Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide
    Maria Laura Zenclussen
    Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto von Guericke University, Gerhart Hauptmann Strasse 35, Magdeburg, Germany
    J Pathol 225:293-304. 2011
    ..the existence of a highly vascularized and transient organ, the placenta, which ensures oxygen supply to the fetus via haemoproteins...
  84. ncbi Circadian rhythms in the fetus
    Maria Seron-Ferre
    Programa de Fisiopatología, Instituto de Ciencias Biomedicas, Universidad de Chile, Chile
    Mol Cell Endocrinol 349:68-75. 2012
    ..By living inside the maternal compartment, the fetus is inevitably exposed to rhythms of the maternal internal milieu such as temperature; rhythms originated by ..
  85. ncbi Do phthalates affect steroidogenesis by the human fetal testis? Exposure of human fetal testis xenografts to di-n-butyl phthalate
    R T Mitchell
    Medical Research Council University of Edinburgh Centre for Reproductive Health, The Queen s Medical Research Institute, Edinburgh Royal Hospital for Sick Children, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    J Clin Endocrinol Metab 97:E341-8. 2012
    ..g. di-n-butyl phthalate (DBP)] causes masculinization disorders in rats, raising concern for similar effects in humans. We investigated whether DBP exposure impairs steroidogenesis by the human fetal testis...
  86. ncbi Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy
    A L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Nat Immunol 2:64-8. 2001
    ..These data show that IDO activity protects the fetus by suppressing T cell-driven local inflammatory responses to fetal alloantigens.
  87. pmc Timed maternal melatonin treatment reverses circadian disruption of the fetal adrenal clock imposed by exposure to constant light
    Natalia Méndez
    Instituto de Anatomia, Histologia y Patologia, Universidad Austral de Chile, Valdivia, Chile
    PLoS ONE 7:e42713. 2012
    ..circadian systems; for instance, the suprachiasmatic nucleus is the master clock in the mother but not in the fetus. Despite this, several tissues/organs display circadian oscillations in the fetus...
  88. pmc Human cytomegalovirus elicits fetal gammadelta T cell responses in utero
    David Vermijlen
    Institute for Medical Immunology, Universite Libre de Bruxelles, 6041 Gosselies, Belgium
    J Exp Med 207:807-21. 2010
    The fetus and infant are highly susceptible to viral infections. Several viruses, including human cytomegalovirus (CMV), cause more severe disease in early life compared with later life...
  89. ncbi Anatomical dimensions of trachea, main bronchi, subcarinal and bronchial angles in fetuses measured ex vivo
    - Harjeet
    Department of Anatomy Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Paediatr Anaesth 18:1029-34. 2008
    ..This study is aimed to determine the anatomical dimensions of trachea, main bronchi, subcarinal and bronchial angles and their correlation to age and crown rump length (CRL) in fetuses...
  90. ncbi Lipid metabolism in the fetus and the newborn
    E Herrera
    Facultad de Ciencias Experimentales y Técnicas, Universidad San Pablo CEU, E 28668 Madrid, Spain
    Diabetes Metab Res Rev 16:202-10. 2000
    ..FFA) are used for ketogenesis by the mother, and ketone bodies are used as fuels and lipogenic substrates by the fetus. Maternal glycerol is preferentially used for glucose synthesis, saving other gluconeogenic substrates, like amino ..
  91. pmc Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents
    Sander van den Driesche
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e37064. 2012
    ....
  92. pmc In utero surgery--current state of the art--part II
    Piotr Wojcicki
    Department of Plastic Surgery, Wrocław Medical University, Polanica Zdrój, Poland
    Med Sci Monit 17:RA262-70. 2011
    ..in the course of intrauterine life dates back to 1963, when Lilly performed the first blood transfusion in a fetus. Since then it has been introduced as a treatment option in a series of lethal malformations...
  93. ncbi Development of microglia in the cerebral white matter of the human fetus and infant
    Saraid S Billiards
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, MA 02115, USA
    J Comp Neurol 497:199-208. 2006
    ..transient overexpression in activated microglial density occurs normally in the cerebral white matter of the human fetus during the peak window of vulnerability for PVL...
  94. ncbi Single molecule sequencing of free DNA from maternal plasma for noninvasive trisomy 21 detection
    Jessica M E van den Oever
    Center for Human and Clinical Genetics, Laboratory for Diagnostic Genome Analysis, Leiden University Medical Center, Leiden, The Netherlands
    Clin Chem 58:699-706. 2012
    ..To eliminate this bias, and thereby experimental noise, we have used single molecule sequencing as an alternative method...
  95. ncbi First- and second-trimester fetal size and asthma outcomes at age 10 years
    Steve Turner
    Academic Child Health, Obstetrics and Gynaecology, University of Aberdeen, Royal Aberdeen Children s Hospital, Foresterhill, Aberdeen, UK
    Am J Respir Crit Care Med 184:407-13. 2011
    ..Greater early fetal size is associated with reduced asthma risk and improved lung function in early childhood...
  96. ncbi The developing intestinal microbiome and its relationship to health and disease in the neonate
    R Murgas Torrazza
    Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    J Perinatol 31:S29-34. 2011
    ....
  97. ncbi Size distributions of maternal and fetal DNA in maternal plasma
    K C Allen Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Clin Chem 50:88-92. 2004
    ..The discovery of fetal DNA in maternal plasma has opened up an approach for noninvasive prenatal diagnosis. Despite the rapid expansion in clinical applications, the molecular characteristics of plasma DNA in pregnant women remain unclear...
  98. ncbi Fetomaternal immunotolerance
    Antonis Makrigiannakis
    Laboratory of Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Crete, Heraklion, Greece
    Am J Reprod Immunol 60:482-96. 2008
    ....
  99. pmc Placental transfer of conjugated bisphenol A and subsequent reactivation in the rat fetus
    Miyu Nishikawa
    Laboratory of Veterinary Biochemistry, Department of Bioscience, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan
    Environ Health Perspect 118:1196-203. 2010
    ..However, in rodents, prenatal exposure to low doses of BPA can adversely affect the fetus, despite the efficient drug-metabolizing systems of the dams...
  100. ncbi PrPSc accumulation in fetal cotyledons of scrapie-resistant lambs is influenced by fetus location in the uterus
    Janet Alverson
    USDA, ARS, Animal Disease Research Unit, 3003 ADBF, Washington State University, Pullman, WA 99164, USA
    J Gen Virol 87:1035-41. 2006
    Placentae from scrapie-infected ewes have been shown to accumulate PrPSc when the genotype of the fetus is of a susceptible genotype (VRQ/VRQ, ARQ/VRQ or ARQ/ARQ)...
  101. pmc Interferon gamma in successful pregnancies
    Shawn P Murphy
    Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA
    Biol Reprod 80:848-59. 2009
    ..This review describes the dynamic roles of IFNG in successful pregnancy and briefly summarizes data on IFNG in gestational pathologies...

Research Grants69

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..These studies will test whether NCSCs with specific regional characteristics can be derived from hES cells and whether these cells engraft in the gut of an animal model of Hirschsprung disease. ..
  2. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    Carole R Mendelson; Fiscal Year: 2013
    ..intriguing evidence that augmented SP-A production by the maturing fetal lung may provide a hormonal signal from fetus to mother leading to the initiation of labor...
  3. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    ..swine bone marrow hematopoietic stem cells (HSC) to repopulate the immune system by injecting into a developing fetus prior to immune maturation...
  4. SPEAKER TRAVEL AND SCIENTIFIC SESSION SUPPORT FOR THE TERATOLOGY SOCIETY 50TH
    Christina Chambers; Fiscal Year: 2011
    ..Add Optional Project Narrative File Delete Optional Project Narrative File View Optional Project Narrative File !"#! ..
  5. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2012
    ..All of the essential LC-PUFA that are acquired by the fetus are actively transported across the placental barrier...
  6. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..These studies will identify an important new source of oxidative stress in PPHN. These observation may lead to new targeted therapies to improve vasodilation and oxygenation in PPHN. ..
  7. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2013
    ..All of the essential LC-PUFA that are acquired by the fetus are actively transported across the placental barrier...
  8. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..Our studies focus on the key periods of development of LCNN from the completion of neurogenesis in the fetus through postnatal maturation and the establishment of functional synaptic connections, and conclude with adulthood ..
  9. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
    ..abstract_text> ..
  10. Transplacental Arsenic Induced Hepatic Dysfunction and Vascular Disease
    J Christopher States; Fiscal Year: 2010
    ..This project uses a mouse model of fetal arsenic exposure induced vascular disease to investigate effects of fetal arsenic exposure on liver development that likely cause vascular disease by young adulthood. ..
  11. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Identification of isolated congenital heart block (CHB) in a fetus predicts with near certainty that the mother, who may have a rheumatic disease or be asymptomatic, will have autoantibodies (Ab) to ..
  12. Maternal One Carbon Metabolism and Low Birth Weight Infant
    Satish C Kalhan; Fiscal Year: 2013
    ..animals have shown that perturbation in the methionine and one carbon metabolism in the mother and possibly in the fetus, impacts fetal growth and "programming" of the metabolism of the infant and ultimately causes the observed ..
  13. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2011
    ..It may also help understanding why in some very poor regions of South Africa the prevalence of FAS is much higher than in Western countries as these populations also experience severe malnutrition. ..
  14. The Impact of Sleep-Disordered Breathing on Adverse Pregnancy Outcomes
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    ..pregnancy affects 5-8% of pregnancies in the United States and contributes to serious complications for both the fetus and mother. Hypertension may lead to pre-eclampsia, which can restrict fetal growth or trigger premature birth...
  15. Adiponectin and fetal programming
    Jianhua Shao; Fiscal Year: 2013
    ..These studies will reveal new pathways of fetal programming that will lead to new therapeutic approaches to stop the vicious cycle of maternal-offspring obesity. ..
  16. Predictors of Dietary Quality in Low-Income Pregnant Women
    Eileen R Fowles; Fiscal Year: 2010
    ..Inadequate placental development can result in a diminished supply of nutrients to the fetus, thus inhibiting proper growth and leading to intrauterine growth restriction...
  17. Human developmental toxicity of metal mixture exposure from e-waste recycling
    Aimin Chen; Fiscal Year: 2010
    ..This study will address the developmental effects of metal mixtures from primitive e-waste recycling activities. It will inform environmental health policy making to manage the e-waste and protect human health. ..
  18. DHA attenuates Inflammatory Responses Through Altering RAGE Signaling
    LYNETTE KAY ROGERS; Fiscal Year: 2013
    ..DHA is preferentially accreted by the third trimester human fetus to aid the maturation of neurological tissues...
  19. Maternal Obesity affects AMP-Kinase in Muscle Cell Differentiation
    Min Du; Fiscal Year: 2013
    ....
  20. Graves'Disease Therapy Risks to Mother and Fetus
    Scott A Rivkees; Fiscal Year: 2013
    ..two specific aims are proposed: Specific Aim 1: Assess the risks of ATD treatment during pregnancy on mother and fetus. Cohort studies will be performed using large clinical databases, including those of Marketscan (>1...
  21. Maternal Obesity and Gestational Diabetes: Impact on Metabolome
    William L Lowe; Fiscal Year: 2013
    ..risks are not known, but the mother's metabolic profile impacts the intrauterine milieu of the developing fetus as glucose and other molecules cross the placenta and impact fetal growth and development...
  22. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    ..Second, these metabolites are able to transmit across the placental barrier and be transferred to the human fetus. Third, with few exceptions, most adverse effects of background levels of PCBs were primarily related to prenatal ..
  23. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ....
  24. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ..When the fetus fails to induce maternal tolerance, the outcome is either immune-mediated abortion or the development of abnormal ..
  25. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..The fetus in utero bears paternal antigens and should be rejected as a foreign graft by the maternal immune system...
  26. Model of the Human Testis for Reproductive Toxicology
    PAUL JACOB TUREK; Fiscal Year: 2011
    ....
  27. Hypoplastic Left Heart Syndrome: Expression of RHD in the Fetus?
    Pirooz Eghtesady; Fiscal Year: 2013
    ..proposal is to test a novel hypothesis that states HLHS is an expression of rheumatic heart disease (RHD) in the fetus. In RHD, among other immunologic processes, anti-streptococcal antibodies are generated in response to strep ..
  28. The role of NLRP7 and related genes in hydatidiform moles and reproductive failur
    Ignatia Van den Veyver; Fiscal Year: 2009
    Hydatidiform moles (HM) are abnormally developing pregnancies with hyperproliferative trophoblast and absence of a fetus. The more common sporadic complete hydatidiform moles are 46,XX or 46,XY androgenetic conceptions, in which all the ..
  29. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
    ..We propose that improved maternal metabolic status and reduced nutrient delivery to the fetus will result in a significant improvement in the long term health of women and their children...
  30. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2011
    ..The TCblR gene knockout is not lethal to the fetus and the homozygous mice appear to develop and breed normally...
  31. NFAT Signaling and Down Syndrome
    Gerald R Crabtree; Fiscal Year: 2012
    ..We will test this hypothesis and if correct find molecule that correct the balance and thereby develop new treatments for some of the disabling characteristics of Down Syndrome. ..
  32. Epigenetics and choline: mediation of fetal alcohol effects in a rat model
    Carol L Cheatham; Fiscal Year: 2013
    ..As a result of being able to move between the clinic and the bench, the candidate will build a strong, independent research program. ..
  33. Interaction of fetal growth and bisphenol A in obesity
    Frederick S vom Saal; Fiscal Year: 2013
    ..Perinatal exposure to BPA is predicted to interact synergistically with IUGR via additional epigenetic changes in adipocytes that alter the expression of estrogen-responsive genes and further accelerate postnatal growth. ..
  34. Feto-maternal DNA/RNA Trafficking: Biology and Application
    Diana W Bianchi; Fiscal Year: 2013
    ..Genomic analysis in the proposed aims will lead to novel insights regarding fetal biological processes, which will result in entirely new approaches to fetal therapy. ..
  35. Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth
    Eugene D Albrecht; Fiscal Year: 2013
    ..e. skeletal muscle, of the fetus leadin to insulin sensitivity/glucose homeostasis after birth...
  36. Ligands and cofactors required for RORgt function in the immune system
    Dan Littman; Fiscal Year: 2013
    ..for the differentiation of Lti cells that induce formation of lymph nodes and Peyer's patches in the fetus and of cryptopatches and isolated lymphoid follicles in the post-natal intestine;and it is required for the ..
  37. Autoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targets
    Yang Xia; Fiscal Year: 2010
    ..PE is also associated with intrauterine growth restriction, a life-threatening condition that puts the fetus at risk for many long term cardiovascular disorders...
  38. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    Hannah C Kinney; Fiscal Year: 2010
    ..abstract_text> ..
  39. Perinatal Assessment of At-Risk Populations
    William P Fifer; Fiscal Year: 2013
    ..team of perinatal researchers in order to develop new risk indices as early as possible In the life of the fetus and young infant...
  40. Regulation and Function of the HCMV pp71 Tegument Protein
    Julie Kerry; Fiscal Year: 2009
    ..In addition, HCMV can cross the placenta and infect the fetus resulting in a high incidence of birth defects such as blindness and deafness...
  41. DAMP-RAGE Signaling and Fetal Injury in Inflammation-Induced Preterm Birth
    Irina A Buhimschi; Fiscal Year: 2013
    ..observational evidence that intra-uterine inflammation induces an imbalance in the redox homeostasis of the human fetus, causing release of DAMP proteins and antenatal fetal cellular damage via RAGE activation;2) In Specific Aim 2 we ..
  42. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    ..e., BBN x @BN, BBN x @L, L mother with BN fetus and BN mother with L fetus at various developmental stages...
  43. Epigenetic programming of brain development by choline nutrition
    Jan Krzysztof Blusztajn; Fiscal Year: 2011
    ....
  44. Prenatal stress and epigenetic programming of the HPA axis and autonomic balance
    Rosalind J Wright; Fiscal Year: 2013
    ..During pregnancy, maternal experiences and conditions, including stress, expose the fetus to hormonal and metabolic cues that may induce 'fetal programming'...
  45. Molecular Basis of Nuchal Edema
    Young Kwon Hong; Fiscal Year: 2013
    Nuchal edema (NE) is a tissue swelling on the back of the neck of fetus due to an abnormal fluid accumulation during human pregnancy and has been associated with fetuses having chromosomal aneuploidy...
  46. Weight management for improved pregnancy outcomes
    Victor J Stevens; Fiscal Year: 2012
    ..These complications include increased risk of miscarriage, stillbirth, having a fetus that is too large leading to cesarean section or birth injuries for mom and baby from vaginal delivery, and death ..
  47. (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION: FETUS AND ADULT
    Lawrence D Longo; Fiscal Year: 2013
    ..provided by applicant): The overall theme of this application is to explore fundamental mechanisms whereby the fetus and adult acclimatize to high altitude, long-term hypoxia (LTH)...
  48. The Effects of Ethanol on Microtubules during Mouse Pre-implantation Development
    Yixian Zheng; Fiscal Year: 2012
    ..Numerous studies have been published characterizing the effect of ethanol on a developing fetus. However, the specific mechanisms have been proven more difficult to establish...
  49. Prenatal stress biology, infant body composition and obesity risk
    Sonja Entringer; Fiscal Year: 2013
    ..sensors" of the quality of the intrauterine environment as well as "transducers" of its effects on the developing fetus and subsequent childhood and adult obesity risk...
  50. Novel vaccine to CMV based on a disc virus
    Alistair McGregor; Fiscal Year: 2010
    ..age, is considered to be a major public health priority because of the risk of congenital infection to the fetus. This application proposes the use of a replication-impaired live CMV vaccine lacking an essential gene...
  51. Maternal Dietary Patterns and Child Weight Status
    Chantel L Martin; Fiscal Year: 2013
    ..be as early as during fetal development and maternal nutrition during pregnancy may play a role in programming the fetus for later development of obesity...
  52. Epigenetic Effects of Prenatal Ethanol Exposure
    Thomas P Yang; Fiscal Year: 2010
    ..ethanol during gestation via maternal intake during pregnancy causes specific epigenetic changes in the developing fetus, particularly in the nervous system...
  53. Pregnancy, Pre-eclampsia, Anti-oxidants and Endothelial Cell Function
    Gautam Chaudhuri; Fiscal Year: 2010
    ..This condition can adversely affect both the mother and the fetus. Pre-eclampsia is more prevalent in Afro-Americans and is also seen in the lower socio-economic groups...
  54. GWA Mapping: Maternal Metabolism-Birth Weight Interactions
    WILLIAM LOWE; Fiscal Year: 2009
    ..New emerging data suggest that genetic variation in the fetus can impact maternal metabolism...
  55. Adipose Stem Cell Therapy for Krabbe Disease
    Bruce Bunnell; Fiscal Year: 2009
    ....
  56. Effects of Maternal Influenza Immunization: A Field Trial in Guatemala'
    Saad B Omer; Fiscal Year: 2010
    ..The secondary infant/fetus outcomes include clinical influenza-like illness, prematurity, birth weight, delivery complications, pneumonia and ..
  57. Causes of rotavirus vaccine failure in Zambian children
    Roma Chilengi; Fiscal Year: 2013
    ..but may relate to continued maternal antigen exposure and high level maternal immunity that is passed to the fetus/newborn transplacentally and/or through breast milk...
  58. Cerebral Artery Alpha1 Adrenergic and PKC Regulatory Mechanisms
    Lawrence D Longo; Fiscal Year: 2013
    ..maturational development alters fundamental signal transduction mechanisms in the cerebrovasculature of the fetus/premature newborn and the adult...
  59. Development of an Inhibitor of Toxoplasma gondii
    Richard D Wood; Fiscal Year: 2010
    ..gondii infection for the first time and transmits the infection to the fetus. Incidence in the U.S. is 1 per 5000 live births...
  60. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2013
    ..is of particular concern in relation to SIDS due to its ability to cross the placenta and concentrate in the fetus, and prenatal nicotine exposure impairs the ability of newborn animals to resuscitate from cardiorespiratory ..
  61. Impact of Catecholamines to Insulin-Glucose Homeostasis in IUGR Fetuses
    Sean W Limesand; Fiscal Year: 2013
    ..the hypothesis that chronic exposure to elevated catecholamine concentrations lowers insulin secretion in the IUGR fetus, but also leads to adrenergic desensitization in 2-cells that enhances glucose stimulated insulin secretion after ..
  62. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    GREGORY TODD PHARR; Fiscal Year: 2010
    ..of pregnancy because their immunosuppressive function allows maternal immune tolerance to the semi-allogeneic fetus. Depletion of Tregs is associated with reproductive failure...
  63. Effects of Methylmercury on Neuronal Cell Migration
    Hitoshi Komuro; Fiscal Year: 2010
    Methylmercury (MeHg) is a well-recognized neurotoxic agent that can affect the fetus. In the tragic disasters that took place at Minamata, Japan, and subsequently in Iraq, many infants were exposed transplacentally to MeHg...
  64. CONFERENCE--ISOLATED FETAL CELLS IN MATERNAL BLOOD
    Joe Simpson; Fiscal Year: 1993
    ..Immunologic signals between mother and fetus will be considered as a clue for explaining the phenomena of fetal cells in maternal blood...
  65. PREVENTION OF X-RAY INDUCED MALFORMATIONS
    MARVIN SODICOFF; Fiscal Year: 1990
    ..The subject of chemical radiation protection of the fetus has been virtually ignored for almost 20 years and certainly since the development of the more potent and less ..
  66. FETAL TRACHEAL OCCLUSION FOR SEVERE DIAPHAGMATIC HERNIA
    Craig Albanese; Fiscal Year: 2000
    ..Although a controlled randomized trial of any fetal treatment poses great difficulties, it is time to establish whether this innovative therapeutic modality should be pursued or abandoned. ..
  67. ONTOGENY OF FETAL HEPATIC SERINE AND GLYCINE METABOLISM
    Michael Narkewicz; Fiscal Year: 1999
    ..Thus, amino acid metabolism is a key element that determines the well- being of the human fetus and newborn. We have focused our studies on serine and glycine, two amino acids with unique fetal characteristics...
  68. FETAL OXYGENATION AND GROWTH DURING MATERNAL ANEMIA
    DANIEL EDELSTONE; Fiscal Year: 1990
    ..The reasons for these poor outcomes are currently unknown, although insufficient availability of oxygen to the fetus, resulting from the mother's anemic state, may be an important factor...
  69. DEVELOPMENT OF THE SECRETORY IMMUNE SYSTEM
    Albert Jones; Fiscal Year: 1991
    ....