umbilical veins

Summary

Summary: Veins which carry oxygenated, nutrient-rich blood from the placenta and which are obliterated in the first few days after birth.

Top Publications

  1. ncbi VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding
    Shay Soker
    Department of Urology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biochem 85:357-68. 2002
  2. ncbi Heterogeneity of microvascular endothelial cells isolated from human term placenta and macrovascular umbilical vein endothelial cells
    Ingrid Lang
    Institute of Histology and Embryology, University of Graz, Graz, Austria
    Eur J Cell Biol 82:163-73. 2003
  3. ncbi Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus
    Jian Xu
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 116:944-53. 2007
  4. ncbi Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production
    Lisa Quagliaro
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    Atherosclerosis 183:259-67. 2005
  5. ncbi Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase
    L Piconi
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    J Thromb Haemost 2:1453-9. 2004
  6. pmc Integrin-mediated signaling events in human endothelial cells
    S M Short
    Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Biol Cell 9:1969-80. 1998
  7. ncbi Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1
    Martin N Nakatsu
    Department of Molecular Biology and Biochemistry, 3219 McGaugh Hall, University of California, Irvine, Irvine, CA 92697, USA
    Microvasc Res 66:102-12. 2003
  8. pmc Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65
    Hideaki Shimada
    Inflammation Research Unit, Pfizer Global Research and Development, Chesterfield, Missouri 63017, USA
    J Biol Chem 285:12536-42. 2010
  9. ncbi Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cells
    Hui Xu
    Department of Pharmacology, Johannes Gutenberg University, D 55131 Mainz, Germany
    Free Radic Biol Med 44:1656-67. 2008
  10. ncbi Heme oxygenase-1 induction may explain the antioxidant profile of aspirin
    Nina Grosser
    Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, Wolfgang Langenbeck Str 4, Halle Saale 06099, Germany
    Biochem Biophys Res Commun 308:956-60. 2003

Detail Information

Publications242 found, 100 shown here

  1. ncbi VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding
    Shay Soker
    Department of Urology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biochem 85:357-68. 2002
    ..These complexes are formed on the surface of EC and in a juxtacrine manner via association of tumor cell NRP1 and EC KDR...
  2. ncbi Heterogeneity of microvascular endothelial cells isolated from human term placenta and macrovascular umbilical vein endothelial cells
    Ingrid Lang
    Institute of Histology and Embryology, University of Graz, Graz, Austria
    Eur J Cell Biol 82:163-73. 2003
    ..These data support evidence for (1) the microvascular identity of the isolated PLEC described in this study, and (2) the phenotypic and physiologic heterogeneity of micro- and macrovascular endothelial cells within one human organ...
  3. ncbi Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus
    Jian Xu
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 116:944-53. 2007
    ....
  4. ncbi Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production
    Lisa Quagliaro
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    Atherosclerosis 183:259-67. 2005
    ....
  5. ncbi Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase
    L Piconi
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    J Thromb Haemost 2:1453-9. 2004
    ..Thus, PARP activation appears to be involved in both promoting nitrosative stress and upregulating adhesion molecules and inflammation in endothelial cells exposed to oscillating high glucose conditions...
  6. pmc Integrin-mediated signaling events in human endothelial cells
    S M Short
    Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Biol Cell 9:1969-80. 1998
    ..Together, these data suggest a cooperation between integrins and soluble mitogens in efficient propagation of signals to downstream kinases. This cooperation may contribute to anchorage dependence of mitogenic cell cycle progression...
  7. ncbi Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1
    Martin N Nakatsu
    Department of Molecular Biology and Biochemistry, 3219 McGaugh Hall, University of California, Irvine, Irvine, CA 92697, USA
    Microvasc Res 66:102-12. 2003
    ..This improved model recapitulates all the major steps of angiogenesis seen in vivo and provides a powerful model for analysis of this complex phenomenon...
  8. pmc Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65
    Hideaki Shimada
    Inflammation Research Unit, Pfizer Global Research and Development, Chesterfield, Missouri 63017, USA
    J Biol Chem 285:12536-42. 2010
    ..This study also provides the first evidence of the critical involvement of ROCK2 in LPA-induced CAM expression through activation of the NF-kappaB pathway in human endothelial cells...
  9. ncbi Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cells
    Hui Xu
    Department of Pharmacology, Johannes Gutenberg University, D 55131 Mainz, Germany
    Free Radic Biol Med 44:1656-67. 2008
    ..Both effects could be reduced by inhibition of NADPH oxidase. Thus, a selective inhibition/knockdown of PKCalpha may represent a novel therapeutic strategy for vascular disease...
  10. ncbi Heme oxygenase-1 induction may explain the antioxidant profile of aspirin
    Nina Grosser
    Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, Wolfgang Langenbeck Str 4, Halle Saale 06099, Germany
    Biochem Biophys Res Commun 308:956-60. 2003
    ..Induction of HO-1 expression and activity may be a novel mechanism by which aspirin prevents cellular injury under inflammatory conditions and in cardiovascular disease...
  11. ncbi Development and characterization of a spheroidal coculture model of endothelial cells and fibroblasts for improving angiogenesis in tissue engineering
    Andreas Wenger
    Department of Plastic, University of Freiburg Medical Center, Freiburg, Germany
    Cells Tissues Organs 181:80-8. 2005
    ..The model system introduced in this study is suitable for the development of a preformed lumenized capillary-like network ex vivo and may therefore be useful for improving angiogenesis in in vivo tissue engineering applications...
  12. ncbi The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research Tumor Biology Center, Breisacher Str 117, 79106 Freiburg, Germany
    Blood 103:4150-6. 2004
    ....
  13. ncbi Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation
    Nan Lan Huang
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Int J Cardiol 134:169-75. 2009
    ..The purpose of the present study was to investigate the anti-inflammatory effects of metformin on endothelial cells and the related molecular mechanisms...
  14. ncbi Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction
    Ludovica Piconi
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    Diabetes Metab Res Rev 22:198-203. 2006
    ..But the possible involvement of this pathway in the hyperglycemia-induced apoptosis of endothelial cells has not yet been reported...
  15. ncbi Tissue engineering: creation of long-lasting blood vessels
    Naoto Koike
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 428:138-9. 2004
    ..These networks are stable and functional for one year in vivo...
  16. ncbi Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase
    Xavier Cullere
    Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Blood 105:1950-5. 2005
    ..Thus, Epac/Rap activation represents a new pathway for regulating endothelial cell barrier function...
  17. ncbi Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia
    Takeshi Nagamatsu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 145:4838-45. 2004
    ..The presented findings might provide a framework with which to understand the mechanism of uterine vascular remodeling and its perturbations as exemplified in preeclampsia...
  18. ncbi Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2
    Matilde Murga
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 105:1992-9. 2005
    ..Based on its dual role as an enhancer of VEGF activity and a mediator of endothelial cell adhesiveness described here, NRP-1 emerges as a promising molecular target for the development of antiangiogenic drugs...
  19. ncbi A protocol for isolation and culture of human umbilical vein endothelial cells
    Bruno Baudin
    Laboratoire de Biochimie et Biologie Cellulaire UPRES JE 2493, UFR de Pharmacie, Universite Paris Sud 11, 3 rue Jean Baptiste Clément, 92290 Chatenay Malabry, France
    Nat Protoc 2:481-5. 2007
    ..Various protocols can be applied to HUVECs, from simple harvesting to a particular solubilization of proteins for proteomic analysis...
  20. ncbi AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells
    Jose M Cacicedo
    Diabetes and Metabolism Research Unit, Department of Medicine and Section of Endocrinology, Boston University School of Medicine, 650 Albany St, 8th Floor, Room 820, Boston, MA 02118, USA
    Biochem Biophys Res Commun 324:1204-9. 2004
    ....
  21. ncbi Effect of Buddleja officinalis on high-glucose-induced vascular inflammation in human umbilical vein endothelial cells
    Yun Jung Lee
    Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570 749, Republic of Korea
    Exp Biol Med (Maywood) 233:694-700. 2008
    ..The present data suggest that ABO could suppress high-glucose-induced vascular inflammatory processes, and ABO may be closely related with the inhibition of ROS and NF-kappaB activation in HUVEC...
  22. ncbi Induction of oxidative stress and human leukocyte/endothelial cell interactions in polycystic ovary syndrome patients with insulin resistance
    Victor M Victor
    Endocrinology Service, University Hospital Doctor Peset, and University Hospital Doctor Peset Foundation, 46017 Valencia, Spain
    J Clin Endocrinol Metab 96:3115-22. 2011
    ..Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial and endothelial function...
  23. ncbi Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495
    Helena Lenasi
    Institut für Kardiovaskuläre Physiologie, Klinikum der JWG Universität, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Cardiovasc Res 59:844-53. 2003
    ..The aim of this investigation was to determine whether or not the activation of the endothelial NO synthase (eNOS) by this Ca2+ antagonist is related to alterations in eNOS phosphorylation...
  24. ncbi Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation
    Marcelo Gonzalez
    Cellular and Molecular Physiology Laboratory and Perinatology Research Laboratory, Division of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 226:2916-24. 2011
    ..We suggest that insulin induces human umbilical vein relaxation by increasing HUVEC L-arginine transport via hCATs (likely hCAT-1) most likely requiring Sp1-activated SLC7A1 expression...
  25. ncbi Long-term in vivo imaging of human angiogenesis: critical role of bone marrow-derived mesenchymal stem cells for the generation of durable blood vessels
    Laura Sanz
    Unidad de Inmunología Molecular, Hospital Universitario Puerta de Hierro, 28035 Madrid, Spain
    Microvasc Res 75:308-14. 2008
    ..In summary, our study offers an unprecedented opportunity to perform long-term serial analysis of the molecular events involved in the angiogenic process and monitoring responses to anti-angiogenic agents...
  26. ncbi Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities
    T Florio
    Farmacologia e Neuroscienze, Istituto Nazionale per la Ricerca sul Cancro, Universita di Genova, 16132 Genova, Italy
    Endocrinology 144:1574-84. 2003
    ..In conclusion, we demonstrate that somatostatin is a powerful antitumor agent in vivo that inhibits tumor angiogenesis through SSTR3-mediated inhibition of both eNOS and MAPK activities...
  27. ncbi Intrauterine growth retardation is associated with reduced activity and expression of the cationic amino acid transport systems y+/hCAT-1 and y+/hCAT-2B and lower activity of nitric oxide synthase in human umbilical vein endothelial cells
    Paola Casanello
    Department of Physiology, Faculty of Biological Sciences, University of Concepcion, Concepcion, Chile
    Circ Res 91:127-34. 2002
    ..Alterations in L-arginine/NO pathway could be critical for the physiological processes involved in the etiology of IUGR in human pregnancies...
  28. ncbi Inhibition of angiogenesis and angiogenesis-dependent tumor growth by the cryptic kringle fragments of human apolipoprotein(a)
    Jang Seong Kim
    Mogam Biotechnology Research Institute, Yongin City, Kyonggi do 449 910, Korea
    J Biol Chem 278:29000-8. 2003
    ..Collectively, these results suggest that a truncated apo(a), rhLK68, is a potent anti-angiogenic and anti-tumor molecule...
  29. ncbi Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1-dependent autocrine production of interleukin-8
    Nelly A Abdel-Malak
    Critical Care and Respiratory Divisions and Meakins Christie Laboratories, Department of Medicine, McGill University Health Centre, McGill University, Montreal, QC, Canada
    Blood 111:4145-54. 2008
    ....
  30. pmc Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells
    D D Wagner
    J Cell Biol 95:355-60. 1982
    ..These data suggest that the Weibel-Palade bodies of endothelial cells are storage and/or processing organelles for von Willebrand protein...
  31. ncbi Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration
    Christopher D Buckley
    The Medical School, The University of Birmingham, UK
    J Leukoc Biol 79:303-11. 2006
    ....
  32. ncbi Effect of thrombin and bradykinin on endothelial cell mechanical properties monitored through membrane deformation
    Charles M Cuerrier
    Departement de Pharmacologie, Universite de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada
    J Mol Recognit 22:389-96. 2009
    ..These changes in the mechanical properties of endothelial cells provide relevant informations in the biological and pathophysiological behaviors of endothelial cells...
  33. ncbi Inosculation of tissue-engineered capillaries with the host's vasculature in a reconstructed skin transplanted on mice
    Pierre Luc Tremblay
    Laboratoire d Organogénèse Expérimentale, Centre Hospitalier Affilie Universitaire De Quebec, Hôpital du St Sacrement and Département de Chirurgie, Quebec, Canada
    Am J Transplant 5:1002-10. 2005
    ..These results open exciting possibilities for the clinical application of many other tissue-engineered organs requiring a rapid vascularization...
  34. ncbi Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TG, UK
    Circ Res 95:884-91. 2004
    ..Our finding demonstrates the dysregulation of the VEGF/PlGF axis in preeclampsia and offers an entirely new therapeutic approach to its treatment...
  35. ncbi HYAL1 overexpression is correlated with the malignant behavior of human breast cancer
    Jin xiang Tan
    Department of Endocrine Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Int J Cancer 128:1303-15. 2011
    ..Further studies showed that the HYAL1, HYAL2 and HA were elevated in breast cancer, and HYAL1 could downregulate HA expression. In conclusion, HYAL1 may be a potential prognostic marker and therapeutic target in breast cancer...
  36. pmc Piper sarmentosum increases nitric oxide production in oxidative stress: a study on human umbilical vein endothelial cells
    Azizah Ugusman
    Department of Physiology, Universiti Kebangsaan, Malaysia Medical Center, Kuala Lumpur, Malaysia
    Clinics (Sao Paulo) 65:709-14. 2010
    ..This study aimed to investigate the effects of Piper sarmentosum on the eNOS and Nitric oxide pathway in cultured human umbilical vein endothelial cells (HUVECs)...
  37. ncbi Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells
    Rodrigo A Panepucci
    Center for Cell Therapy and Regional Blood Center, Department of Clinical Medicine, Faculty of Medicine, Ribeirao Preto, Brazil
    Stem Cells 22:1263-78. 2004
    ....
  38. pmc Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A
    Masashi Narazaki
    Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive 12N226, Bethesda, MD 20892 1907
    Blood 107:3892-901. 2006
    ..These results demonstrate that preferential receptor binding and internalization by a ligand are mechanisms by which the common receptor Npn-1 can play an essential role in prioritizing conflicting signals...
  39. ncbi Endothelial cell swelling by aldosterone
    H Oberleithner
    Institute of Physiology I, Nanolab, University of Munster, Robert Koch Str 27a, D 48149 Munster, Germany
    J Membr Biol 196:163-72. 2003
    ..ii). Intracellular macromolecule shifts cause the changes in cell volume. (iii). Both amiloride and spironolactone may be useful for medical applications to prevent aldosterone-induced vasculopathies...
  40. pmc Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes
    Zhonglin Xie
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Diabetes 57:3222-30. 2008
    ..The present study was conducted to determine how AMPK activation suppressed tyrosine nitration of prostacyclin synthase in diabetes...
  41. ncbi Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1
    Azucena Salas
    Center For Blood Research and Departments of Pathology and Anesthesia, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:50255-62. 2002
    ..An allosteric small molecule antagonist of alpha(L)beta(2) inhibits both rolling adhesion and firm adhesion, which has important implications for its mode of action in vivo...
  42. ncbi Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity
    Maria De La Luz Sierra
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 103:2452-9. 2004
    ..The differential processing of SDF-1alpha and SDF-1beta provides biologic significance to the existence of 2 splice forms of the chemokine and adds a tool to precisely regulate SDF-1's biologic activity by changes in specific activity...
  43. ncbi Induction of pluripotency in human endothelial cells resets epigenetic profile on genome scale
    Maria A Lagarkova
    Vavilov Institute of General Genetics RAS and LKT Ltd, Moscow, Russia
    Cell Cycle 9:937-46. 2010
    ..Our findings demonstrate that iPS cells can be generated from human endothelial cells and reprogramming resets epigenetic status of endothelial cells to pluripotency...
  44. pmc VEGF-Trap: a VEGF blocker with potent antitumor effects
    Jocelyn Holash
    Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 99:11393-8. 2002
    ..VEGF-Trap-mediated blockade may be superior to that achieved by other agents, such as monoclonal antibodies targeted against the VEGF receptor...
  45. ncbi Rho protein inactivation induced apoptosis of cultured human endothelial cells
    Stefan Hippenstiel
    Charite, Department of Internal Medicine, Humboldt University, 13353 Berlin, Germany
    Am J Physiol Lung Cell Mol Physiol 283:L830-8. 2002
    ..Caspase-3 activity and apoptosis induced by TcdB-10463 were abolished by cAMP elevation. In summary, inhibition of Rho in endothelial cells activates caspase-9- and -3-dependent apoptosis, which can be antagonized by cAMP elevation...
  46. ncbi Interferon-alpha prevents apoptosis of endothelial cells after short-term exposure but induces replicative senescence after continuous stimulation
    Johannes Pammer
    Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria
    Lab Invest 86:997-1007. 2006
    ..Furthermore IFN-alpha released in chronic inflammatory conditions might contribute via its prosenescent activity to the pathogenesis of atherosclerosis...
  47. ncbi Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells
    Rania Harfouche
    Critical Care and Respiratory Divisions, McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada
    Microvasc Res 64:135-47. 2002
    ..We conclude that Ang-1 inhibits endothelial cell apoptosis through several pathways, which include PI-3 kinase/AKT activation, inhibition of Smac release from the mitochondria, and upregulation of Survivin protein...
  48. ncbi Interleukin-17 promotes angiogenesis and tumor growth
    Muneo Numasaki
    Department of Surgery, School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Blood 101:2620-7. 2003
    ..Furthermore, they suggest that inhibition of biologic action of IL-17 may have therapeutic benefits when applied to angiogenesis-related disorders...
  49. ncbi Effect of HUVEC on human osteoprogenitor cell differentiation needs heterotypic gap junction communication
    F Villars
    INSERM U 443, université Bordeaux 2 Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Am J Physiol Cell Physiol 282:C775-85. 2002
    ..This stimulation could be mediated by the intercellular diffusion of signaling molecules that permeate the junctional channel...
  50. ncbi Fetal liver-sparing cardiovascular adaptations linked to mother's slimness and diet
    Guttorm Haugen
    Division of Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
    Circ Res 96:12-4. 2005
    ..Consequences of such "liver-sparing" may underlie the increased cardiovascular risk of people whose mothers were slimmer and had lower body fat stores in pregnancy...
  51. ncbi Hydrogen peroxide increases human leukocyte adhesion to porcine aortic endothelial cells via NFkappaB-dependent up-regulation of VCAM-1
    Sukmook Lee
    Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Int Immunol 19:1349-59. 2007
    ..In summary, our results suggest that NFkappaB-dependent porcine VCAM-1 expression by H(2)O(2) may promote interaction of human leukocyte to PAECs, and thus may play an important role on inducing xenogeneic immune responses...
  52. ncbi Ductus venosus shunting in growth-restricted fetuses and the effect of umbilical circulatory compromise
    T Kiserud
    Department of Clinical Medicine, Section of Obstetrics and Gynaecology, University of Bergen, Norway
    Ultrasound Obstet Gynecol 28:143-9. 2006
    ..To determine the degree of ductus venosus (DV) shunting in fetuses with intrauterine growth restriction (IUGR) and the effect of various degrees of umbilical circulatory compromise...
  53. ncbi Sirt1 modulates premature senescence-like phenotype in human endothelial cells
    Hidetaka Ota
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Mol Cell Cardiol 43:571-9. 2007
    ..Our data suggest that Sirt1 may exert protective effects against endothelial dysfunction by preventing stress-induced premature senescence and deranged expression of PAI-1 and eNOS...
  54. pmc Transendothelial migration of neutrophils involves integrin-associated protein (CD47)
    D Cooper
    Hanson Centre for Cancer Research, Adelaide, Australia
    Proc Natl Acad Sci U S A 92:3978-82. 1995
    ..These data implicate IAP as the third molecule essential for neutrophil migration through endothelium into sites of inflammation...
  55. pmc The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration
    Cary Esselens
    Medical Oncology Research Program, Research Institute Foundation and Vall d Hebron Institute of Oncology, Vall d Hebron University Hospital, Psg Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Biol Chem 285:2463-73. 2010
    ..Here, we show that the cleavage of semaphorin 3C induced by ADAMTS1 promotes the migration of breast cancer cells, indicating that the co-expression of these molecules in tumors may contribute to the metastatic program...
  56. pmc Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow
    Hendra Setiadi
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 111:1989-98. 2008
    ..Distribution in both domains markedly enhances E-selectin's ability to mediate leukocyte rolling under flow...
  57. pmc Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells
    Guang Fa Wang
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    Acta Pharmacol Sin 30:589-96. 2009
    ..The present study investigates whether genipin, an aglycon of geniposide, inhibits endothelial exocytosis...
  58. ncbi Lipopolysaccharide induces autophagy through BIRC2 in human umbilical vein endothelial cells
    Ning Meng
    Institute of Developmental Biology, School of Life Science, Shandong University, Jinan, China
    J Cell Physiol 225:174-9. 2010
    ..Furthermore, knockdown of BIRC2 by RNA interference inhibited the autophagy and the translocation of p53 to nuclei induced by LPS. These data suggest a novel role for BIRC2 in LPS-induced autophagy in VECs...
  59. ncbi Phosphatidylinositol inhibits vascular endothelial growth factor-A--induced migration of human umbilical vein endothelial cells
    Nozomu Matsunaga
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    J Pharmacol Sci 106:128-35. 2008
    ..Therefore, PI may be expected to prevent some diseases caused by angiogenesis...
  60. ncbi Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner
    Ping Song
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Circulation 116:1585-95. 2007
    ..Oxidative stress plays a causal role in vascular injury in diabetes mellitus, but the mechanisms and targets remain poorly understood...
  61. ncbi Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress
    Elisabeth Dernbach
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Blood 104:3591-7. 2004
    ..Taken together, EPCs reveal a higher expression of antioxidative enzymes and, thus, are exquisitely equipped to be protected against oxidative stress consistent with their progenitor cell character...
  62. ncbi Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo
    Maria J Calzada
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Circ Res 94:462-70. 2004
    ..Therefore, alpha4beta1 is an important endothelial cell receptor for mediating motility and proliferative responses to thrombospondins and for modulation of angiogenesis...
  63. ncbi Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5
    Joel Abramowitz
    Department of Medicine, Section of Cardiovascular Science, Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 108:3048-53. 2003
    ..We studied the growth-promoting effects of 2 sodium pump-selective cardiotonic steroids, ouabain and marinobufagenin, on cultured cells from vascular smooth muscle (VSMCs) from human umbilical vein and a rat VSMC line, A7r5...
  64. ncbi Portal and umbilical venous blood supply to the liver in the human fetus near term
    G Haugen
    Centre for Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
    Ultrasound Obstet Gynecol 24:599-605. 2004
    ..To determine the contribution of the umbilical (UV) and portal (PV) veins to blood supply to the human fetal liver in a low-risk population near term, and to assess the distribution between the left and right lobes...
  65. ncbi Longitudinal umbilical vein blood flow changes in normal and growth-retarded fetuses
    Edoardo Di Naro
    Departments of Obstetrics and Gynecology, University of Bari, Italy
    Acta Obstet Gynecol Scand 81:527-33. 2002
    ..To explore whether the umbilical vein blood flow of growth-retarded fetuses with normal Doppler parameters changes over time differently to that of normally grown fetuses...
  66. ncbi Venous liver blood flow and regulation of human fetal growth: evidence from macrosomic fetuses
    Jörg Kessler
    Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, Norway
    Am J Obstet Gynecol 204:429.e1-7. 2011
    ..Experimental studies show that fetal liver venous perfusion is a determinant for growth in utero. Here we explore the relationship between fetal venous blood flow to the liver and macrosomia...
  67. ncbi Withaferin A is a potent inhibitor of angiogenesis
    Royce Mohan
    Discovery Research, EntreMed, Inc, Rockville, Maryland, USA
    Angiogenesis 7:115-22. 2004
    ..In conclusion, our findings identify a novel mode of action of withaferin A, which highlights the potential use of this natural product for cancer treatment or prevention...
  68. ncbi F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial cells: role in inflammatory thrombosis
    Anna Babinska
    Department of Anatomy Cell Biology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Thromb Haemost 88:843-50. 2002
    ..Agents that block the F11R-mediated adhesion of platelets to EC may be of therapeutic value in controlling thrombosis and preventing heart attacks and stroke...
  69. ncbi Fetal hemodynamic development in macrosomic growth
    C Ebbing
    Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway and Department of Clinical Medicine, University of Bergen, Norway
    Ultrasound Obstet Gynecol 38:303-8. 2011
    ..To determine the venous and arterial hemodynamics underlying macrosomic fetal growth...
  70. ncbi Quantitative analysis of the microstructure of human umbilical vein for assessing feasibility as vessel substitute
    Wen Chun Li
    Institute of Basic Medical Sciences, Yunyang Medical College, Shiyan, People s Republic of China
    Ann Vasc Surg 22:417-24. 2008
    ..g., brachial, ulnar, radial, right coronary, anterior tibial, and posterior tibial). HUV is one of several graft materials that may be used when autogenous saphenous vein is absent or inadequate...
  71. ncbi Longitudinal study of umbilical and portal venous blood flow to the fetal liver: low pregnancy weight gain is associated with preferential supply to the fetal left liver lobe
    Jörg Kessler
    Department of Clinical Medicine, University of Bergen, N 5020 Bergen, Norway
    Pediatr Res 63:315-20. 2008
    ....
  72. pmc TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype
    Richard C A Sainson
    Department of Molecular Biology and Biochemistry, University of California, Irvine, USA
    Blood 111:4997-5007. 2008
    ....
  73. pmc A translocated bacterial protein protects vascular endothelial cells from apoptosis
    Michael C Schmid
    Division of Molecular Microbiology, Biozentrum, University of Basel, Basel, Switzerland
    PLoS Pathog 2:e115. 2006
    ....
  74. ncbi Silymarin inhibits TNF-alpha-induced expression of adhesion molecules in human umbilical vein endothelial cells
    Jong Soon Kang
    Biopotency Evaluation Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon 305 333, South Korea
    FEBS Lett 550:89-93. 2003
    ..Taken together, these results demonstrate that silymarin exerts an anti-atherosclerotic activity, at least in part, by inhibiting the expression of adhesion molecules...
  75. ncbi Differential effects of orbital and laminar shear stress on endothelial cells
    Alan Dardik
    Section of Vascular Surery, Yale University School of Medicine, New Haven, CT 06519, USA
    J Vasc Surg 41:869-80. 2005
    ..The effects of orbital and laminar shear stress on EC morphology, proliferation, and apoptosis were compared...
  76. ncbi Bartonella-induced endothelial cell proliferation is mediated by release of calcium from intracellular stores
    Amy M McCord
    Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, Florida, USA
    DNA Cell Biol 26:657-63. 2007
    ..henselae-induced HUVEC proliferation and CXCL8 production. These results implicate intracellular Ca2+ pools in B. henselae-induced angiogenesis and may lead to increased understanding of the mechanisms of pathogen-induced angiogenesis...
  77. ncbi Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism
    Hsinyu Lee
    Department of Life Science and Institute of Zoology, National Taiwan University, Taipei, Taiwan 106, ROC
    Am J Physiol Cell Physiol 287:C1657-66. 2004
    ....
  78. ncbi Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium
    Gonzalo Munoz
    Cellular and Molecular Physiology Laboratory CMPL, Medical Research Centre CIM, Department of Obstetrics and Gynaecology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 209:826-35. 2006
    ..as a mechanism regulating adenosine plasma concentration, and therefore its vascular effects in human umbilical veins. Thus, altered expression and/or activity of hENT1 or hENT2 could lead to abnormal physiological plasma ..
  79. pmc The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis
    C T Kuo
    Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 11:2996-3006. 1997
    ..This bleeding disorder was associated with specific defects in blood vessel morphology. Umbilical veins and arteries in the LKLF-/- embryos displayed an abnormally thin tunica media and aneurysmal dilatation ..
  80. ncbi ZD6126: a novel small molecule vascular targeting agent
    David C Blakey
    Department of Cancer and Infection Bioscience, AstraZeneca, Alderley Park, England, Macclesfield, UK
    Int J Radiat Oncol Biol Phys 54:1497-502. 2002
    ..The aim of these studies was to evaluate factors that contribute to the selectivity of the novel vascular targeting agent ZD6126...
  81. ncbi Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis
    Massimo M Santoro
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94158, USA
    Nat Genet 39:1397-402. 2007
    ....
  82. ncbi A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms
    Brett R Blackman
    Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biomech Eng 124:397-407. 2002
    ..These results thus reveal a unique responsiveness of ECs to an arterial waveform and begin to elucidate the complex sensing capabilities of the endothelium to the dynamic characteristics of flows throughout the human vascular tree...
  83. ncbi Extrajunctional distribution of N-cadherin in cultured human endothelial cells
    D Salomon
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Cell Sci 102:7-17. 1992
    ..Comparison of this pattern with the discrete junctional labeling obtained with the pan-cadherin antibody suggests that different cadherins, co-expressed in the same endothelial cells, may undergo differential surface distribution...
  84. ncbi Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    J E Park
    Genentech, Inc, South San Francisco, California 94080
    J Biol Chem 269:25646-54. 1994
    ..Purified PIGF isoforms had little or no direct mitogenic or permeability-enhancing activity. However, they were able to significantly potentiate the action of low concentrations of VEGF in vitro and, more strikingly, in vivo...
  85. ncbi Shear stress enhances human endothelial cell wound closure in vitro
    M L Albuquerque
    Department of Pediatrics, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Am J Physiol Heart Circ Physiol 279:H293-302. 2000
    ..Cell spreading and migration, but not proliferation, were the major mechanisms accounting for the increases in wound closure rate. These results suggest that physiological levels of shear stress enhance endothelial repair...
  86. ncbi Increased expression of extracellular proteins as a hallmark of human endothelial cell in vitro senescence
    B Hampel
    Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria
    Exp Gerontol 41:474-81. 2006
    ..The results described here support a new model, where changes in the secretome of human endothelial cells contribute to vascular aging and vascular pathology...
  87. ncbi p21-activated kinase regulates endothelial permeability through modulation of contractility
    Rebecca A Stockton
    Cardiovascular Research Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Biol Chem 279:46621-30. 2004
    ..PAK may therefore be a suitable drug target for the treatment of pathological conditions where vascular leak is a contributing factor, such as ischemia and inflammation...
  88. ncbi Effect of interleukin-1 blockers, CK112, and CK116 on rat experimental choroidal neovascularization in vivo and endothelial cell cultures in vitro
    Yanhong Zou
    Institute of Ocular Pharmacology, Medical Pharmacology and Toxicology, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843, USA
    J Ocul Pharmacol Ther 22:19-25. 2006
    ..The aim of this study was to investigate the effect of interleukin-1 blockers, CK112 and CK116, on laser-induced experimental choroidal neovascularization (CNV) in rat models in vivo and endothelial cell proliferation in vitro...
  89. ncbi VEGF profiling and angiogenesis in human microtissues
    Jens M Kelm
    Institute for Chemical and Bio Engineering, Swiss Federal Institute of Technology, ETH Hoenggerberg, HCI F115, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    J Biotechnol 118:213-29. 2005
    ..Precise understanding of vascularization in human microtissues may foster advances in clinical tissue implant engineering, tumor treatment, as well as drug discovery and drug-function analysis...
  90. ncbi CDK2 translational down-regulation during endothelial senescence
    Deborah A Freedman
    Vascular Biology Program, Department of Surgery, Children s Hospital, 1 Blackfan Circle, Harvard University Medical School, Karp Family Research Laboratories, Floor 12, Boston, MA 02115, USA
    Exp Cell Res 307:118-30. 2005
    ..Understanding the mechanisms regulating endothelial senescence will be critical in determining the role of endothelial senescence in tumor growth...
  91. ncbi Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell
    Youichiro Wada
    The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215, USA
    FASEB J 19:1914-6. 2005
    ..Taken together, these data suggest that inflammatory mediators prime endothelial cells to modulate subsequent thrombin response...
  92. ncbi Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black Americans
    R Preston Mason
    Elucida Research, Beverly, Massachusetts, USA
    Circulation 112:3795-801. 2005
    ..The ability to pharmacologically reverse endothelial dysfunction in blacks was tested with nebivolol, a beta1-selective agent with vasodilating and antioxidant properties...
  93. ncbi Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesis
    Xiping Xin
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Lab Invest 84:1451-9. 2004
    ..These results suggested that glucose-induced, ET- and PKC-dependent, upregulation of FN is, in part, mediated via MAPK/ERK activation...
  94. pmc Anthrax lethal toxin induces human endothelial cell apoptosis
    James E Kirby
    Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Infect Immun 72:430-9. 2004
    ..I also hypothesize that the observed endothelial toxicity contributes to vascular pathology and hemorrhage during systemic anthrax...
  95. ncbi In vitro model of a vascular stroma for the engineering of vascularized tissues
    B Frerich
    Department of Oral and Maxillofacial Surgery and Plastic Facial Surgery, University of Leipzig, Germany
    Int J Oral Maxillofac Surg 30:414-20. 2001
    ....
  96. ncbi Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases
    Rory R Koenen
    MedicalFaculty, Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    Blood 113:4799-809. 2009
    ....
  97. ncbi Use of a phage display library to identify oligopeptides binding to the lumenal surface of polarized endothelium by ex vivo perfusion of human umbilical veins
    Fukuto Maruta
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Drug Target 11:53-9. 2003
    ..b>Umbilical veins were cleaned in situ and M13 phage display libraries were passed through the cords...
  98. ncbi Accuracy of Doppler echocardiography for the diagnosis of thrombosis associated with umbilical venous catheters
    Madan Roy
    Departments of Pediatrics, Radiology, and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Pediatr 140:131-4. 2002
    ..Corresponding specificities were 91%, 76%, and 94%. We conclude that asymptomatic thrombosis is common in sick newborn infants with UVCs. Contrast venography is required to accurately diagnose such thrombi in affected patients...
  99. doi Insulin resistance affects gene expression in endothelium
    Claudia Consoli
    Arterioscler Thromb Vasc Biol 28:e7-9. 2008
  100. ncbi CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells
    Hiroshi Kojima
    Division of Hematology, Institute of Clinical Medicine and Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Biol Chem 278:36748-53. 2003
    ..Anti-CD226 monoclonal antibody inhibited binding of megakaryocytic cell lines to HUVEC. Taken together, these results reveal a novel mechanism for adhesion of platelets and megakaryocytic cells to vascular endothelial cells...
  101. ncbi Changes of vasodilator-stimulated phosphoprotein (VASP) and its phosphorylation in endothelial cells exposed to laminar flow
    Lei Wei
    Group Mechanics and Cell and Tissue Engineering, LEMTA UMR 7563 CNRS INPL UHP and IFR 111 Bioengineering, 54500 Vandoeuvre les Nancy, France
    Clin Hemorheol Microcirc 28:113-20. 2003
    ..These results suggest that a laminar shear stress can induce VASP translocation and phosphorylation that proceed actin filaments rearrangement along with the flow direction in HUVECs...

Research Grants63

  1. VON WILLEBRAND FACTOR, FIBRINOLYSIS, & THE ENDOTHELIUM
    Karen Hamilton; Fiscal Year: 1991
    ..Experiments will be performed on cultured human endothelial cells obtained from umbilical veins, adult arteries and veins, and adipose tissue microvasculature. Intracellular vWF Structure and Release...
  2. Development and assessment of a natural bio scafold for vascular reconstruction
    PETER STUART MCFETRIDGE; Fiscal Year: 2012
    ..A unique approach is taken using a bioscaffold derived from the human umbilical veins that have been [unreadable]machined[unreadable] from umbilical cords to yield a mechanically uniform, ..
  3. Estrogen enhancement of endothelial vasodilatory factors
    Roshanak Rahimian; Fiscal Year: 2003
    ..and aortic rings taken from different groups of rats as well as in endothelial cells derived from human umbilical veins (HUVECs). EDRF release will be measured using Bioassay...
  4. ASSESSMENT OF INTRAPORTAL HEPATOCYTE TRANSPLANTATION
    GEOFFREY BUDD; Fiscal Year: 1980
    ..Isolated, labeled, rabbit hepatocytes will be transplanted via mesenteric or umbilical veins into recipient new born and developing rabbits to investigate the potentialities of these routes as ..
  5. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2010
    ..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..
  6. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
    ..Results obtained from the proposed work should enhance our knowledge and establish a direct link of placental TC activity and EC dysfunction in PE. ..
  7. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  8. Modulation of integrin function by cytoplasmic signals
    Ulhas Naik; Fiscal Year: 2007
    ..Further, characterization of CIB and its interactions with integrin alphaIIb-beta3 and Plk3 may help in delineating the mechanisms by which cytoplasmic signals modulate integrin function. ..
  9. Role of JAM Family in Angiogenesis
    Ulhas P Naik; Fiscal Year: 2010
    ..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a mew line of investigation that is important in tumerigenesis and vascular biology. ..
  10. Adrenomedullin and Human Trophoblast Invasion
    Yuan Lin Dong; Fiscal Year: 2006
    ..Knowledge gained from these studies may assist in designing appropriate therapeutic strategies to prevent preeclampsia in the human. ..
  11. Fetal Velocimetry & Amino Acid Transport in Pregnancy
    FREDERICK BATTAGLIA; Fiscal Year: 2007
    ..These studies will establish important links between blood flow changes in the fetus and nutrient delivery to the fetus. ..
  12. Endocytosis in cardiac myocytes
    Ion Jovin; Fiscal Year: 2005
    ..The discoverry of polypeptides that guide macromolecules to specific cellular organelles or compartments can have profound implications for understanding microbial invasion and for refining gene therapy. ..
  13. Micro-Thickness Collagen Membranes in Tissue Engineering
    Robert Vernon; Fiscal Year: 2007
    ..Moreover, data from this work will serve as a foundation for further development of TEBVs. Accordingly, this application is well suited to the purpose of the R21 mechanism. [unreadable] [unreadable] [unreadable]..
  14. A transmembrane collagen induced in prostate cancer
    Bruce Zetter; Fiscal Year: 2007
    ..Correlation with patient data will enable us to determine whether collagen XXIII has use as a diagnostic or predictive marker in prostate cancer. ..
  15. Novel High Content Vascular Patterning Assay(RMI)
    Royce Mohan; Fiscal Year: 2007
    ..We beleve that this HC-HTS platform will offer unique opportunities to screen vast numbers of small molecule inhibitors of angiogenesis and assist in drug discovery. ..
  16. Ras-PI3K Pathway in Nf1-/-Hematopoiesis and Leukemia
    David Ingram; Fiscal Year: 2007
    ..abstract_text> ..
  17. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2007
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
  18. RICKETTSIA-INDUCED TRANSCRIPTIONAL ACTIVATION
    SANJEEV SAHNI; Fiscal Year: 2007
    ..These studies will offer important perspectives in our understanding of rickettsial pathogenesis and may lead to the identification of novel targets for supplemental chemotherapy. ..
  19. Modulation of Host Cell Apoptosis By Pathogenic Rickettsiae
    SANJEEV SAHNI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  20. Targeted enzyme delivery systems for treatment of orphan niemann-pick disease
    SILVIA MURO GALINDO; Fiscal Year: 2007
    ..The clinical benefits of this strategy may be extended to other LSDs. [unreadable] [unreadable] [unreadable] [unreadable]..
  21. FASL IN PREECLAMPSIA AND IMMUNOTOLERANCE TO THE FETUS
    Scott Kauma; Fiscal Year: 2002
    ..These studies will significantly advance our understanding of the mechanisms involved in the pathogenesis of preeclampsia and provide new rationales for the treatment of this disease. ..
  22. Selective subplate vulnerability and cortical plasticity
    Patrick McQuillen; Fiscal Year: 2008
    ..Finally, we hypothesize that treatments that protect sub-plate neurons in vitro will also prevent sub-plate neuron cell death following early hypoxia ischemia. [unreadable] [unreadable]..
  23. ENDOTHELIAL-DEPENDENT VASODILATATION IN PREECLAMPSIA
    Scott Kauma; Fiscal Year: 2003
    ..The K24 award will protect this candidates time and help him to mature into a senior investigator in OB/GYN. ..
  24. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA MOHAN RAO LELLA; Fiscal Year: 2010
    ..abstract_text> ..
  25. EICOSANOIDS AND PULMONARY VASCULAR TONE
    SANDRA PFISTER; Fiscal Year: 2002
    ....
  26. Molecular Biology of Erythrocyte Ankyrin
    Patrick G Gallagher; Fiscal Year: 2010
    ..These studies may provide important information to be used for diagnosis and treatment of patients with this disorder. ..
  27. SHIFTS IN ACTIN-MICROTUBULE FORCES IN THE ENDOTHELIUM
    ALAN MOY; Fiscal Year: 2004
    ..We will utilize molecular approaches and quantitative dynamic imaging approaches in living cells to further validate our hypothesis. We believe that the results of these studies will greatly advance vascular and cell biology. ..
  28. THE ROLE OF MEN IN FAMILY FORMATION AND PARENTING
    Renata Forste; Fiscal Year: 2001
    ..Overall, the primary aim of the study is to heighten understanding of the mechanisms underlying the role of men in nonmarital childbearing, as well as the early involvement of men with their children. ..
  29. Cord Blood Cells in ALS: Replacement of Protection?
    Svitlana Garbuzova Davis; Fiscal Year: 2004
    ..The results of this study may provide the basis for developing a novel, non-invasive therapy, easily accessed by ALS patients. ..
  30. White Matter Injury in Critical Ill Newborns With Congenital Heart Disease
    Patrick Sean McQuillen; Fiscal Year: 2010
    ..Page McQuillen, Patrick S. ..
  31. PREVENTION OF VASCULOPATHY AND NEPHROPATHY IN METABOLIC SYNDROME
    Michael S Goligorsky; Fiscal Year: 2010
    ..abstract_text> ..
  32. Regulatory Oxygenases in Vasculopathic Rickettsioses
    SANJEEV SAHNI; Fiscal Year: 2010
    ....
  33. Injury - Induced Endothelial Dysfunction
    Fiemu Nwariaku; Fiscal Year: 2008
    ..The overall objectives are to determine the role of intracellular oxidants, rho and MAPK pathways on junctional phosphorylation and endothelial dysfunction. [unreadable] [unreadable]..
  34. Genotypic Determinants of Aspirin Response in High Risk Families
    Lewis Becker; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
    ....
  36. Genome-Wide Association of Platelet Phenotypes
    Lewis Becker; Fiscal Year: 2009
    ..This study represents the first genome -wide SNP association study of comprehensive platelet function and should lead to novel tailored anti-platelet therapy for the prevention of vascular thromboses. (End of Abstract) ..
  37. Receptor Tyrosine Kinases in Mechanotransduction
    Zheng Gen Jin; Fiscal Year: 2009
    ..In this pathway, VEGFR2 may emerge as a central mediator for laminar flow atheroprotective effects, which will provide new insight into the prevention of atherosclerotic vascular disease. ..
  38. PKD Family Kinases and Idiopathic Pulmonary Fibrosis
    Hua Tang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  39. INTEGRINS IN ACUTE RENAL FAILURE
    MICHAEL GOLIGORSKY; Fiscal Year: 2002
    ....
  40. Hematopoietic Precursor Development from Human Embryonic Stem (ES) Cells
    Dan S Kaufman; Fiscal Year: 2010
    ..These cells may also be used as a new source for transfusion medicine. ..
  41. Single-Molecule Immunoassay and DNA Screening
    Edward Yeung; Fiscal Year: 2005
    ..The first two goals will be the focus of the R21 Phase and the last two goals will be the focus of the R33 Phase of this application. ..
  42. Purinergic signaling in endothelial cells.
    Elzbieta Kaczmarek; Fiscal Year: 2005
    ..abstract_text> ..
  43. Mechanism of anti-phagocytosis by Yersinia pestis
    Kristiina Vuori; Fiscal Year: 2005
    ..We further expect that the inhibitors to be identified will be a valuable starting point for the further development of novel drugs that can be used to combat plague mortality. ..
  44. In Vivo Potential of Human ES Cell-Derived Blood Cells
    DAN KAUFMAN; Fiscal Year: 2004
    ..abstract_text> ..
  45. TARGETED ULTRASOUND IMAGING OF TUMORS
    Paul Dayton; Fiscal Year: 2004
    ..Finally, the effect of contrast agent localization due to acoustic radiation force will be studied on targeting efficiency. ..
  46. SIGNAL TRANSDUCTION BY P130CAS AND C CRK
    Kristiina Vuori; Fiscal Year: 2004
    ..Once completed, these studies are expected to yield significant new information on the role of the Cas-Crk signaling complex in intracellular signaling events. ..
  47. Retrotransposons as site-specific gene delivery vectors
    JOHN GOODIER; Fiscal Year: 2003
    ..In addition, I will assay in cell culture the efficiency of the L1 at integrating increasing lengths of exogenous DNA. ..
  48. SUBPLATE NEURONS AND EARLY HYPOXIC ISCHEMIC BRAIN INJURY
    Patrick McQuillen; Fiscal Year: 2002
    ....
  49. Bartonella Inhibitory Factor for Endothelial Cell Growth
    MICHAEL MINNICK; Fiscal Year: 2002
    ..abstract_text> ..
  50. DETERMINANTS OF CORONARY DISEASE IN HIGH RISK FAMILIES
    Lewis Becker; Fiscal Year: 2001
    ..This study will provide important insights into the phenotypic and genetic determinants of clinical and occult CHD in families with premature CHD. ..
  51. CONFERENCE/WORKSHOP ON EPR SPECTROSCOPY AND IMAGING
    Periannan Kuppusamy; Fiscal Year: 2005
    ..S. members of the International Advisory Committee for this meeting. Particular emphasis will be given to the minority and women scientists, encouraging their active participation. ..
  52. ENDOTHELIAL DYSFUNCTION: FORMATION OF MICROPARTICLES
    Sergey Brodsky; Fiscal Year: 2005
    ..The proposed studies may provide novel information on the contribution of microparticles to the pathophysiology of endothelial cell dysfunction and coagulation abnormalities. ..
  53. In Vivo EPR Imaging of Redox Status and Thiols in Tumor
    Periannan Kuppusamy; Fiscal Year: 2007
    ..The results will enable a better understanding of the development of drug resistance in ovarian cancer and offer efficient diagnosis for effective treatment of ovarian cancer patients. ..
  54. Endothelial dysfunction in acute renal ischemia
    MICHAEL GOLIGORSKY; Fiscal Year: 2007
    ..Number of publicationsand manuscriptsacceptedfor publication (not to exceed 10) 10 Other items (list): 1. Color illustrations from the grant application 2. Movies - intravital videomicroscopy supplement ..
  55. Junction Adhesion Molecule CAR and the Immune System
    Steven Carson; Fiscal Year: 2007
    ..This work will advance knowledge of cells that form tight _junctions and their interactions with cells and molecules that must cross those barriers. ..
  56. SIGNAL TRANSDUCTION THOUGH THE C-CBL PROTOONCOGENE
    Kristiina Vuori; Fiscal Year: 2001
    ..In each case, the effects on various biochemical and biological signaling events will be studied. ..
  57. Biosensor to measure microscopic cell function
    ALAN MOY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  58. Coronary Disease Detection by Thalluim SPECT and Fast CT
    Lewis Becker; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  59. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2006
    ..abstract_text> ..
  60. Oral infection and inflammation in transplant patients
    Anna Dongari Bagtzoglou; Fiscal Year: 2005
    ....
  61. Iron and O2 in the Regulation of P. aeruginosa Virulence
    Michael Vasil; Fiscal Year: 2003
    ..This project will investigate the role of PA-Fur and PA-Fur regulated genes in the pathogenesis of P. aeruginosa infections for the ultimate goal or developing novel antimicrobial agents against this formidable opportunist. ..
  62. Novel Class of Phospholipases-Molecular Pathogenesis
    Michael Vasil; Fiscal Year: 2007
    ..Furthermore, it is likely that information we derive from our efforts will also provide additional insights about the biochemistry and biology of PLCs in general. ..
  63. Fetal and Neonatal Hemodynamics in IUGR Pregnancies
    Henry Galan; Fiscal Year: 2006
    ..abstract_text> ..