Genomes and Genes
Summary: Veins which carry oxygenated, nutrient-rich blood from the placenta and which are obliterated in the first few days after birth.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications242 found, 100 shown here
- VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor bindingShay Soker
Department of Urology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Cell Biochem 85:357-68. 2002..These complexes are formed on the surface of EC and in a juxtacrine manner via association of tumor cell NRP1 and EC KDR...
- Heterogeneity of microvascular endothelial cells isolated from human term placenta and macrovascular umbilical vein endothelial cellsIngrid Lang
Institute of Histology and Embryology, University of Graz, Graz, Austria
Eur J Cell Biol 82:163-73. 2003..These data support evidence for (1) the microvascular identity of the isolated PLEC described in this study, and (2) the phenotypic and physiologic heterogeneity of micro- and macrovascular endothelial cells within one human organ...
- Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitusJian Xu
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Circulation 116:944-53. 2007....
- Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide productionLisa Quagliaro
Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
Atherosclerosis 183:259-67. 2005....
- Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymeraseL Piconi
Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
J Thromb Haemost 2:1453-9. 2004..Thus, PARP activation appears to be involved in both promoting nitrosative stress and upregulating adhesion molecules and inflammation in endothelial cells exposed to oscillating high glucose conditions...
- Integrin-mediated signaling events in human endothelial cellsS M Short
Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mol Biol Cell 9:1969-80. 1998..Together, these data suggest a cooperation between integrins and soluble mitogens in efficient propagation of signals to downstream kinases. This cooperation may contribute to anchorage dependence of mitogenic cell cycle progression...
- Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1Martin N Nakatsu
Department of Molecular Biology and Biochemistry, 3219 McGaugh Hall, University of California, Irvine, Irvine, CA 92697, USA
Microvasc Res 66:102-12. 2003..This improved model recapitulates all the major steps of angiogenesis seen in vivo and provides a powerful model for analysis of this complex phenomenon...
- Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65Hideaki Shimada
Inflammation Research Unit, Pfizer Global Research and Development, Chesterfield, Missouri 63017, USA
J Biol Chem 285:12536-42. 2010..This study also provides the first evidence of the critical involvement of ROCK2 in LPA-induced CAM expression through activation of the NF-kappaB pathway in human endothelial cells...
- Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cellsHui Xu
Department of Pharmacology, Johannes Gutenberg University, D 55131 Mainz, Germany
Free Radic Biol Med 44:1656-67. 2008..Both effects could be reduced by inhibition of NADPH oxidase. Thus, a selective inhibition/knockdown of PKCalpha may represent a novel therapeutic strategy for vascular disease...
- Heme oxygenase-1 induction may explain the antioxidant profile of aspirinNina Grosser
Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, Wolfgang Langenbeck Str 4, Halle Saale 06099, Germany
Biochem Biophys Res Commun 308:956-60. 2003..Induction of HO-1 expression and activity may be a novel mechanism by which aspirin prevents cellular injury under inflammatory conditions and in cardiovascular disease...
- Development and characterization of a spheroidal coculture model of endothelial cells and fibroblasts for improving angiogenesis in tissue engineeringAndreas Wenger
Department of Plastic, University of Freiburg Medical Center, Freiburg, Germany
Cells Tissues Organs 181:80-8. 2005..The model system introduced in this study is suitable for the development of a preformed lumenized capillary-like network ex vivo and may therefore be useful for improving angiogenesis in in vivo tissue engineering applications...
- The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodiesUlrike Fiedler
Department of Vascular Biology and Angiogenesis Research Tumor Biology Center, Breisacher Str 117, 79106 Freiburg, Germany
Blood 103:4150-6. 2004....
- Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylationNan Lan Huang
Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
Int J Cardiol 134:169-75. 2009..The purpose of the present study was to investigate the anti-inflammatory effects of metformin on endothelial cells and the related molecular mechanisms...
- Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproductionLudovica Piconi
Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
Diabetes Metab Res Rev 22:198-203. 2006..But the possible involvement of this pathway in the hyperglycemia-induced apoptosis of endothelial cells has not yet been reported...
- Tissue engineering: creation of long-lasting blood vesselsNaoto Koike
Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 428:138-9. 2004..These networks are stable and functional for one year in vivo...
- Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPaseXavier Cullere
Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Blood 105:1950-5. 2005..Thus, Epac/Rap activation represents a new pathway for regulating endothelial cell barrier function...
- Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsiaTakeshi Nagamatsu
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Endocrinology 145:4838-45. 2004..The presented findings might provide a framework with which to understand the mechanism of uterine vascular remodeling and its perturbations as exemplified in preeclampsia...
- Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2Matilde Murga
Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
Blood 105:1992-9. 2005..Based on its dual role as an enhancer of VEGF activity and a mediator of endothelial cell adhesiveness described here, NRP-1 emerges as a promising molecular target for the development of antiangiogenic drugs...
- A protocol for isolation and culture of human umbilical vein endothelial cellsBruno Baudin
Laboratoire de Biochimie et Biologie Cellulaire UPRES JE 2493, UFR de Pharmacie, Universite Paris Sud 11, 3 rue Jean Baptiste Clément, 92290 Chatenay Malabry, France
Nat Protoc 2:481-5. 2007..Various protocols can be applied to HUVECs, from simple harvesting to a particular solubilization of proteins for proteomic analysis...
- AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cellsJose M Cacicedo
Diabetes and Metabolism Research Unit, Department of Medicine and Section of Endocrinology, Boston University School of Medicine, 650 Albany St, 8th Floor, Room 820, Boston, MA 02118, USA
Biochem Biophys Res Commun 324:1204-9. 2004....
- Effect of Buddleja officinalis on high-glucose-induced vascular inflammation in human umbilical vein endothelial cellsYun Jung Lee
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570 749, Republic of Korea
Exp Biol Med (Maywood) 233:694-700. 2008..The present data suggest that ABO could suppress high-glucose-induced vascular inflammatory processes, and ABO may be closely related with the inhibition of ROS and NF-kappaB activation in HUVEC...
- Induction of oxidative stress and human leukocyte/endothelial cell interactions in polycystic ovary syndrome patients with insulin resistanceVictor M Victor
Endocrinology Service, University Hospital Doctor Peset, and University Hospital Doctor Peset Foundation, 46017 Valencia, Spain
J Clin Endocrinol Metab 96:3115-22. 2011..Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial and endothelial function...
- Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495Helena Lenasi
Institut für Kardiovaskuläre Physiologie, Klinikum der JWG Universität, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
Cardiovasc Res 59:844-53. 2003..The aim of this investigation was to determine whether or not the activation of the endothelial NO synthase (eNOS) by this Ca2+ antagonist is related to alterations in eNOS phosphorylation...
- Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxationMarcelo Gonzalez
Cellular and Molecular Physiology Laboratory and Perinatology Research Laboratory, Division of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
J Cell Physiol 226:2916-24. 2011..We suggest that insulin induces human umbilical vein relaxation by increasing HUVEC L-arginine transport via hCATs (likely hCAT-1) most likely requiring Sp1-activated SLC7A1 expression...
- Long-term in vivo imaging of human angiogenesis: critical role of bone marrow-derived mesenchymal stem cells for the generation of durable blood vesselsLaura Sanz
Unidad de Inmunología Molecular, Hospital Universitario Puerta de Hierro, 28035 Madrid, Spain
Microvasc Res 75:308-14. 2008..In summary, our study offers an unprecedented opportunity to perform long-term serial analysis of the molecular events involved in the angiogenic process and monitoring responses to anti-angiogenic agents...
- Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activitiesT Florio
Farmacologia e Neuroscienze, Istituto Nazionale per la Ricerca sul Cancro, Universita di Genova, 16132 Genova, Italy
Endocrinology 144:1574-84. 2003..In conclusion, we demonstrate that somatostatin is a powerful antitumor agent in vivo that inhibits tumor angiogenesis through SSTR3-mediated inhibition of both eNOS and MAPK activities...
- Intrauterine growth retardation is associated with reduced activity and expression of the cationic amino acid transport systems y+/hCAT-1 and y+/hCAT-2B and lower activity of nitric oxide synthase in human umbilical vein endothelial cellsPaola Casanello
Department of Physiology, Faculty of Biological Sciences, University of Concepcion, Concepcion, Chile
Circ Res 91:127-34. 2002..Alterations in L-arginine/NO pathway could be critical for the physiological processes involved in the etiology of IUGR in human pregnancies...
- Inhibition of angiogenesis and angiogenesis-dependent tumor growth by the cryptic kringle fragments of human apolipoprotein(a)Jang Seong Kim
Mogam Biotechnology Research Institute, Yongin City, Kyonggi do 449 910, Korea
J Biol Chem 278:29000-8. 2003..Collectively, these results suggest that a truncated apo(a), rhLK68, is a potent anti-angiogenic and anti-tumor molecule...
- Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1-dependent autocrine production of interleukin-8Nelly A Abdel-Malak
Critical Care and Respiratory Divisions and Meakins Christie Laboratories, Department of Medicine, McGill University Health Centre, McGill University, Montreal, QC, Canada
Blood 111:4145-54. 2008....
- Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cellsD D Wagner
J Cell Biol 95:355-60. 1982..These data suggest that the Weibel-Palade bodies of endothelial cells are storage and/or processing organelles for von Willebrand protein...
- Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migrationChristopher D Buckley
The Medical School, The University of Birmingham, UK
J Leukoc Biol 79:303-11. 2006....
- Effect of thrombin and bradykinin on endothelial cell mechanical properties monitored through membrane deformationCharles M Cuerrier
Departement de Pharmacologie, Universite de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada
J Mol Recognit 22:389-96. 2009..These changes in the mechanical properties of endothelial cells provide relevant informations in the biological and pathophysiological behaviors of endothelial cells...
- Inosculation of tissue-engineered capillaries with the host's vasculature in a reconstructed skin transplanted on micePierre Luc Tremblay
Laboratoire d Organogénèse Expérimentale, Centre Hospitalier Affilie Universitaire De Quebec, Hôpital du St Sacrement and Département de Chirurgie, Quebec, Canada
Am J Transplant 5:1002-10. 2005..These results open exciting possibilities for the clinical application of many other tissue-engineered organs requiring a rapid vascularization...
- Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsiaShakil Ahmad
Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TG, UK
Circ Res 95:884-91. 2004..Our finding demonstrates the dysregulation of the VEGF/PlGF axis in preeclampsia and offers an entirely new therapeutic approach to its treatment...
- HYAL1 overexpression is correlated with the malignant behavior of human breast cancerJin xiang Tan
Department of Endocrine Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
Int J Cancer 128:1303-15. 2011..Further studies showed that the HYAL1, HYAL2 and HA were elevated in breast cancer, and HYAL1 could downregulate HA expression. In conclusion, HYAL1 may be a potential prognostic marker and therapeutic target in breast cancer...
- Piper sarmentosum increases nitric oxide production in oxidative stress: a study on human umbilical vein endothelial cellsAzizah Ugusman
Department of Physiology, Universiti Kebangsaan, Malaysia Medical Center, Kuala Lumpur, Malaysia
Clinics (Sao Paulo) 65:709-14. 2010..This study aimed to investigate the effects of Piper sarmentosum on the eNOS and Nitric oxide pathway in cultured human umbilical vein endothelial cells (HUVECs)...
- Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cellsRodrigo A Panepucci
Center for Cell Therapy and Regional Blood Center, Department of Clinical Medicine, Faculty of Medicine, Ribeirao Preto, Brazil
Stem Cells 22:1263-78. 2004....
- Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3AMasashi Narazaki
Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive 12N226, Bethesda, MD 20892 1907
Blood 107:3892-901. 2006..These results demonstrate that preferential receptor binding and internalization by a ligand are mechanisms by which the common receptor Npn-1 can play an essential role in prioritizing conflicting signals...
- Endothelial cell swelling by aldosteroneH Oberleithner
Institute of Physiology I, Nanolab, University of Munster, Robert Koch Str 27a, D 48149 Munster, Germany
J Membr Biol 196:163-72. 2003..ii). Intracellular macromolecule shifts cause the changes in cell volume. (iii). Both amiloride and spironolactone may be useful for medical applications to prevent aldosterone-induced vasculopathies...
- Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetesZhonglin Xie
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Diabetes 57:3222-30. 2008..The present study was conducted to determine how AMPK activation suppressed tyrosine nitration of prostacyclin synthase in diabetes...
- Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1Azucena Salas
Center For Blood Research and Departments of Pathology and Anesthesia, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:50255-62. 2002..An allosteric small molecule antagonist of alpha(L)beta(2) inhibits both rolling adhesion and firm adhesion, which has important implications for its mode of action in vivo...
- Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversityMaria De La Luz Sierra
Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 103:2452-9. 2004..The differential processing of SDF-1alpha and SDF-1beta provides biologic significance to the existence of 2 splice forms of the chemokine and adds a tool to precisely regulate SDF-1's biologic activity by changes in specific activity...
- Induction of pluripotency in human endothelial cells resets epigenetic profile on genome scaleMaria A Lagarkova
Vavilov Institute of General Genetics RAS and LKT Ltd, Moscow, Russia
Cell Cycle 9:937-46. 2010..Our findings demonstrate that iPS cells can be generated from human endothelial cells and reprogramming resets epigenetic status of endothelial cells to pluripotency...
- VEGF-Trap: a VEGF blocker with potent antitumor effectsJocelyn Holash
Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
Proc Natl Acad Sci U S A 99:11393-8. 2002..VEGF-Trap-mediated blockade may be superior to that achieved by other agents, such as monoclonal antibodies targeted against the VEGF receptor...
- Rho protein inactivation induced apoptosis of cultured human endothelial cellsStefan Hippenstiel
Charite, Department of Internal Medicine, Humboldt University, 13353 Berlin, Germany
Am J Physiol Lung Cell Mol Physiol 283:L830-8. 2002..Caspase-3 activity and apoptosis induced by TcdB-10463 were abolished by cAMP elevation. In summary, inhibition of Rho in endothelial cells activates caspase-9- and -3-dependent apoptosis, which can be antagonized by cAMP elevation...
- Interferon-alpha prevents apoptosis of endothelial cells after short-term exposure but induces replicative senescence after continuous stimulationJohannes Pammer
Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria
Lab Invest 86:997-1007. 2006..Furthermore IFN-alpha released in chronic inflammatory conditions might contribute via its prosenescent activity to the pathogenesis of atherosclerosis...
- Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cellsRania Harfouche
Critical Care and Respiratory Divisions, McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada
Microvasc Res 64:135-47. 2002..We conclude that Ang-1 inhibits endothelial cell apoptosis through several pathways, which include PI-3 kinase/AKT activation, inhibition of Smac release from the mitochondria, and upregulation of Survivin protein...
- Interleukin-17 promotes angiogenesis and tumor growthMuneo Numasaki
Department of Surgery, School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
Blood 101:2620-7. 2003..Furthermore, they suggest that inhibition of biologic action of IL-17 may have therapeutic benefits when applied to angiogenesis-related disorders...
- Effect of HUVEC on human osteoprogenitor cell differentiation needs heterotypic gap junction communicationF Villars
INSERM U 443, université Bordeaux 2 Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
Am J Physiol Cell Physiol 282:C775-85. 2002..This stimulation could be mediated by the intercellular diffusion of signaling molecules that permeate the junctional channel...
- Fetal liver-sparing cardiovascular adaptations linked to mother's slimness and dietGuttorm Haugen
Division of Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
Circ Res 96:12-4. 2005..Consequences of such "liver-sparing" may underlie the increased cardiovascular risk of people whose mothers were slimmer and had lower body fat stores in pregnancy...
- Hydrogen peroxide increases human leukocyte adhesion to porcine aortic endothelial cells via NFkappaB-dependent up-regulation of VCAM-1Sukmook Lee
Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
Int Immunol 19:1349-59. 2007..In summary, our results suggest that NFkappaB-dependent porcine VCAM-1 expression by H(2)O(2) may promote interaction of human leukocyte to PAECs, and thus may play an important role on inducing xenogeneic immune responses...
- Ductus venosus shunting in growth-restricted fetuses and the effect of umbilical circulatory compromiseT Kiserud
Department of Clinical Medicine, Section of Obstetrics and Gynaecology, University of Bergen, Norway
Ultrasound Obstet Gynecol 28:143-9. 2006..To determine the degree of ductus venosus (DV) shunting in fetuses with intrauterine growth restriction (IUGR) and the effect of various degrees of umbilical circulatory compromise...
- Sirt1 modulates premature senescence-like phenotype in human endothelial cellsHidetaka Ota
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Mol Cell Cardiol 43:571-9. 2007..Our data suggest that Sirt1 may exert protective effects against endothelial dysfunction by preventing stress-induced premature senescence and deranged expression of PAI-1 and eNOS...
- Transendothelial migration of neutrophils involves integrin-associated protein (CD47)D Cooper
Hanson Centre for Cancer Research, Adelaide, Australia
Proc Natl Acad Sci U S A 92:3978-82. 1995..These data implicate IAP as the third molecule essential for neutrophil migration through endothelium into sites of inflammation...
- The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migrationCary Esselens
Medical Oncology Research Program, Research Institute Foundation and Vall d Hebron Institute of Oncology, Vall d Hebron University Hospital, Psg Vall d Hebron 119 129, 08035 Barcelona, Spain
J Biol Chem 285:2463-73. 2010..Here, we show that the cleavage of semaphorin 3C induced by ADAMTS1 promotes the migration of breast cancer cells, indicating that the co-expression of these molecules in tumors may contribute to the metastatic program...
- Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flowHendra Setiadi
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Blood 111:1989-98. 2008..Distribution in both domains markedly enhances E-selectin's ability to mediate leukocyte rolling under flow...
- Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cellsGuang Fa Wang
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
Acta Pharmacol Sin 30:589-96. 2009..The present study investigates whether genipin, an aglycon of geniposide, inhibits endothelial exocytosis...
- Lipopolysaccharide induces autophagy through BIRC2 in human umbilical vein endothelial cellsNing Meng
Institute of Developmental Biology, School of Life Science, Shandong University, Jinan, China
J Cell Physiol 225:174-9. 2010..Furthermore, knockdown of BIRC2 by RNA interference inhibited the autophagy and the translocation of p53 to nuclei induced by LPS. These data suggest a novel role for BIRC2 in LPS-induced autophagy in VECs...
- Phosphatidylinositol inhibits vascular endothelial growth factor-A--induced migration of human umbilical vein endothelial cellsNozomu Matsunaga
Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
J Pharmacol Sci 106:128-35. 2008..Therefore, PI may be expected to prevent some diseases caused by angiogenesis...
- Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent mannerPing Song
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Circulation 116:1585-95. 2007..Oxidative stress plays a causal role in vascular injury in diabetes mellitus, but the mechanisms and targets remain poorly understood...
- Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stressElisabeth Dernbach
Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Blood 104:3591-7. 2004..Taken together, EPCs reveal a higher expression of antioxidative enzymes and, thus, are exquisitely equipped to be protected against oxidative stress consistent with their progenitor cell character...
- Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivoMaria J Calzada
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
Circ Res 94:462-70. 2004..Therefore, alpha4beta1 is an important endothelial cell receptor for mediating motility and proliferative responses to thrombospondins and for modulation of angiogenesis...
- Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5Joel Abramowitz
Department of Medicine, Section of Cardiovascular Science, Baylor College of Medicine, Houston, Tex 77030, USA
Circulation 108:3048-53. 2003..We studied the growth-promoting effects of 2 sodium pump-selective cardiotonic steroids, ouabain and marinobufagenin, on cultured cells from vascular smooth muscle (VSMCs) from human umbilical vein and a rat VSMC line, A7r5...
- Portal and umbilical venous blood supply to the liver in the human fetus near termG Haugen
Centre for Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
Ultrasound Obstet Gynecol 24:599-605. 2004..To determine the contribution of the umbilical (UV) and portal (PV) veins to blood supply to the human fetal liver in a low-risk population near term, and to assess the distribution between the left and right lobes...
- Longitudinal umbilical vein blood flow changes in normal and growth-retarded fetusesEdoardo Di Naro
Departments of Obstetrics and Gynecology, University of Bari, Italy
Acta Obstet Gynecol Scand 81:527-33. 2002..To explore whether the umbilical vein blood flow of growth-retarded fetuses with normal Doppler parameters changes over time differently to that of normally grown fetuses...
- Venous liver blood flow and regulation of human fetal growth: evidence from macrosomic fetusesJörg Kessler
Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, Norway
Am J Obstet Gynecol 204:429.e1-7. 2011..Experimental studies show that fetal liver venous perfusion is a determinant for growth in utero. Here we explore the relationship between fetal venous blood flow to the liver and macrosomia...
- Withaferin A is a potent inhibitor of angiogenesisRoyce Mohan
Discovery Research, EntreMed, Inc, Rockville, Maryland, USA
Angiogenesis 7:115-22. 2004..In conclusion, our findings identify a novel mode of action of withaferin A, which highlights the potential use of this natural product for cancer treatment or prevention...
- F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial cells: role in inflammatory thrombosisAnna Babinska
Department of Anatomy Cell Biology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Thromb Haemost 88:843-50. 2002..Agents that block the F11R-mediated adhesion of platelets to EC may be of therapeutic value in controlling thrombosis and preventing heart attacks and stroke...
- Fetal hemodynamic development in macrosomic growthC Ebbing
Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway and Department of Clinical Medicine, University of Bergen, Norway
Ultrasound Obstet Gynecol 38:303-8. 2011..To determine the venous and arterial hemodynamics underlying macrosomic fetal growth...
- Quantitative analysis of the microstructure of human umbilical vein for assessing feasibility as vessel substituteWen Chun Li
Institute of Basic Medical Sciences, Yunyang Medical College, Shiyan, People s Republic of China
Ann Vasc Surg 22:417-24. 2008..g., brachial, ulnar, radial, right coronary, anterior tibial, and posterior tibial). HUV is one of several graft materials that may be used when autogenous saphenous vein is absent or inadequate...
- Longitudinal study of umbilical and portal venous blood flow to the fetal liver: low pregnancy weight gain is associated with preferential supply to the fetal left liver lobeJörg Kessler
Department of Clinical Medicine, University of Bergen, N 5020 Bergen, Norway
Pediatr Res 63:315-20. 2008....
- TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotypeRichard C A Sainson
Department of Molecular Biology and Biochemistry, University of California, Irvine, USA
Blood 111:4997-5007. 2008....
- A translocated bacterial protein protects vascular endothelial cells from apoptosisMichael C Schmid
Division of Molecular Microbiology, Biozentrum, University of Basel, Basel, Switzerland
PLoS Pathog 2:e115. 2006....
- Silymarin inhibits TNF-alpha-induced expression of adhesion molecules in human umbilical vein endothelial cellsJong Soon Kang
Biopotency Evaluation Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon 305 333, South Korea
FEBS Lett 550:89-93. 2003..Taken together, these results demonstrate that silymarin exerts an anti-atherosclerotic activity, at least in part, by inhibiting the expression of adhesion molecules...
- Differential effects of orbital and laminar shear stress on endothelial cellsAlan Dardik
Section of Vascular Surery, Yale University School of Medicine, New Haven, CT 06519, USA
J Vasc Surg 41:869-80. 2005..The effects of orbital and laminar shear stress on EC morphology, proliferation, and apoptosis were compared...
- Bartonella-induced endothelial cell proliferation is mediated by release of calcium from intracellular storesAmy M McCord
Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, Florida, USA
DNA Cell Biol 26:657-63. 2007..henselae-induced HUVEC proliferation and CXCL8 production. These results implicate intracellular Ca2+ pools in B. henselae-induced angiogenesis and may lead to increased understanding of the mechanisms of pathogen-induced angiogenesis...
- Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanismHsinyu Lee
Department of Life Science and Institute of Zoology, National Taiwan University, Taipei, Taiwan 106, ROC
Am J Physiol Cell Physiol 287:C1657-66. 2004....
- Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endotheliumGonzalo Munoz
Cellular and Molecular Physiology Laboratory CMPL, Medical Research Centre CIM, Department of Obstetrics and Gynaecology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
J Cell Physiol 209:826-35. 2006..as a mechanism regulating adenosine plasma concentration, and therefore its vascular effects in human umbilical veins. Thus, altered expression and/or activity of hENT1 or hENT2 could lead to abnormal physiological plasma ..
- The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesisC T Kuo
Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
Genes Dev 11:2996-3006. 1997..This bleeding disorder was associated with specific defects in blood vessel morphology. Umbilical veins and arteries in the LKLF-/- embryos displayed an abnormally thin tunica media and aneurysmal dilatation ..
- ZD6126: a novel small molecule vascular targeting agentDavid C Blakey
Department of Cancer and Infection Bioscience, AstraZeneca, Alderley Park, England, Macclesfield, UK
Int J Radiat Oncol Biol Phys 54:1497-502. 2002..The aim of these studies was to evaluate factors that contribute to the selectivity of the novel vascular targeting agent ZD6126...
- Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasisMassimo M Santoro
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94158, USA
Nat Genet 39:1397-402. 2007....
- A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveformsBrett R Blackman
Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Biomech Eng 124:397-407. 2002..These results thus reveal a unique responsiveness of ECs to an arterial waveform and begin to elucidate the complex sensing capabilities of the endothelium to the dynamic characteristics of flows throughout the human vascular tree...
- Extrajunctional distribution of N-cadherin in cultured human endothelial cellsD Salomon
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
J Cell Sci 102:7-17. 1992..Comparison of this pattern with the discrete junctional labeling obtained with the pan-cadherin antibody suggests that different cadherins, co-expressed in the same endothelial cells, may undergo differential surface distribution...
- Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDRJ E Park
Genentech, Inc, South San Francisco, California 94080
J Biol Chem 269:25646-54. 1994..Purified PIGF isoforms had little or no direct mitogenic or permeability-enhancing activity. However, they were able to significantly potentiate the action of low concentrations of VEGF in vitro and, more strikingly, in vivo...
- Shear stress enhances human endothelial cell wound closure in vitroM L Albuquerque
Department of Pediatrics, Northwestern University Medical School, Chicago, Illinois 60611, USA
Am J Physiol Heart Circ Physiol 279:H293-302. 2000..Cell spreading and migration, but not proliferation, were the major mechanisms accounting for the increases in wound closure rate. These results suggest that physiological levels of shear stress enhance endothelial repair...
- Increased expression of extracellular proteins as a hallmark of human endothelial cell in vitro senescenceB Hampel
Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria
Exp Gerontol 41:474-81. 2006..The results described here support a new model, where changes in the secretome of human endothelial cells contribute to vascular aging and vascular pathology...
- p21-activated kinase regulates endothelial permeability through modulation of contractilityRebecca A Stockton
Cardiovascular Research Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Biol Chem 279:46621-30. 2004..PAK may therefore be a suitable drug target for the treatment of pathological conditions where vascular leak is a contributing factor, such as ischemia and inflammation...
- Effect of interleukin-1 blockers, CK112, and CK116 on rat experimental choroidal neovascularization in vivo and endothelial cell cultures in vitroYanhong Zou
Institute of Ocular Pharmacology, Medical Pharmacology and Toxicology, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843, USA
J Ocul Pharmacol Ther 22:19-25. 2006..The aim of this study was to investigate the effect of interleukin-1 blockers, CK112 and CK116, on laser-induced experimental choroidal neovascularization (CNV) in rat models in vivo and endothelial cell proliferation in vitro...
- VEGF profiling and angiogenesis in human microtissuesJens M Kelm
Institute for Chemical and Bio Engineering, Swiss Federal Institute of Technology, ETH Hoenggerberg, HCI F115, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
J Biotechnol 118:213-29. 2005..Precise understanding of vascularization in human microtissues may foster advances in clinical tissue implant engineering, tumor treatment, as well as drug discovery and drug-function analysis...
- CDK2 translational down-regulation during endothelial senescenceDeborah A Freedman
Vascular Biology Program, Department of Surgery, Children s Hospital, 1 Blackfan Circle, Harvard University Medical School, Karp Family Research Laboratories, Floor 12, Boston, MA 02115, USA
Exp Cell Res 307:118-30. 2005..Understanding the mechanisms regulating endothelial senescence will be critical in determining the role of endothelial senescence in tumor growth...
- Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cellYouichiro Wada
The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215, USA
FASEB J 19:1914-6. 2005..Taken together, these data suggest that inflammatory mediators prime endothelial cells to modulate subsequent thrombin response...
- Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black AmericansR Preston Mason
Elucida Research, Beverly, Massachusetts, USA
Circulation 112:3795-801. 2005..The ability to pharmacologically reverse endothelial dysfunction in blacks was tested with nebivolol, a beta1-selective agent with vasodilating and antioxidant properties...
- Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesisXiping Xin
Department of Pathology, University of Western Ontario, London, Ontario, Canada
Lab Invest 84:1451-9. 2004..These results suggested that glucose-induced, ET- and PKC-dependent, upregulation of FN is, in part, mediated via MAPK/ERK activation...
- Anthrax lethal toxin induces human endothelial cell apoptosisJames E Kirby
Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Infect Immun 72:430-9. 2004..I also hypothesize that the observed endothelial toxicity contributes to vascular pathology and hemorrhage during systemic anthrax...
- In vitro model of a vascular stroma for the engineering of vascularized tissuesB Frerich
Department of Oral and Maxillofacial Surgery and Plastic Facial Surgery, University of Leipzig, Germany
Int J Oral Maxillofac Surg 30:414-20. 2001....
- Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinasesRory R Koenen
MedicalFaculty, Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
Blood 113:4799-809. 2009....
- Use of a phage display library to identify oligopeptides binding to the lumenal surface of polarized endothelium by ex vivo perfusion of human umbilical veinsFukuto Maruta
Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
J Drug Target 11:53-9. 2003..b>Umbilical veins were cleaned in situ and M13 phage display libraries were passed through the cords...
- Accuracy of Doppler echocardiography for the diagnosis of thrombosis associated with umbilical venous cathetersMadan Roy
Departments of Pediatrics, Radiology, and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
J Pediatr 140:131-4. 2002..Corresponding specificities were 91%, 76%, and 94%. We conclude that asymptomatic thrombosis is common in sick newborn infants with UVCs. Contrast venography is required to accurately diagnose such thrombi in affected patients...
- Insulin resistance affects gene expression in endotheliumClaudia Consoli
Arterioscler Thromb Vasc Biol 28:e7-9. 2008
- CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cellsHiroshi Kojima
Division of Hematology, Institute of Clinical Medicine and Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
J Biol Chem 278:36748-53. 2003..Anti-CD226 monoclonal antibody inhibited binding of megakaryocytic cell lines to HUVEC. Taken together, these results reveal a novel mechanism for adhesion of platelets and megakaryocytic cells to vascular endothelial cells...
- Changes of vasodilator-stimulated phosphoprotein (VASP) and its phosphorylation in endothelial cells exposed to laminar flowLei Wei
Group Mechanics and Cell and Tissue Engineering, LEMTA UMR 7563 CNRS INPL UHP and IFR 111 Bioengineering, 54500 Vandoeuvre les Nancy, France
Clin Hemorheol Microcirc 28:113-20. 2003..These results suggest that a laminar shear stress can induce VASP translocation and phosphorylation that proceed actin filaments rearrangement along with the flow direction in HUVECs...
- VON WILLEBRAND FACTOR, FIBRINOLYSIS, & THE ENDOTHELIUMKaren Hamilton; Fiscal Year: 1991..Experiments will be performed on cultured human endothelial cells obtained from umbilical veins, adult arteries and veins, and adipose tissue microvasculature. Intracellular vWF Structure and Release...
- Development and assessment of a natural bio scafold for vascular reconstructionPETER STUART MCFETRIDGE; Fiscal Year: 2012..A unique approach is taken using a bioscaffold derived from the human umbilical veins that have been [unreadable]machined[unreadable] from umbilical cords to yield a mechanically uniform, ..
- Estrogen enhancement of endothelial vasodilatory factorsRoshanak Rahimian; Fiscal Year: 2003..and aortic rings taken from different groups of rats as well as in endothelial cells derived from human umbilical veins (HUVECs). EDRF release will be measured using Bioassay...
- ASSESSMENT OF INTRAPORTAL HEPATOCYTE TRANSPLANTATIONGEOFFREY BUDD; Fiscal Year: 1980..Isolated, labeled, rabbit hepatocytes will be transplanted via mesenteric or umbilical veins into recipient new born and developing rabbits to investigate the potentialities of these routes as ..
- ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIAYuping Wang; Fiscal Year: 2010..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..
- PLACENTAL FUNCTION IN PREECLAMPSIAYuping Wang; Fiscal Year: 2009..Results obtained from the proposed work should enhance our knowledge and establish a direct link of placental TC activity and EC dysfunction in PE. ..
- Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancerShaker Mousa; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Modulation of integrin function by cytoplasmic signalsUlhas Naik; Fiscal Year: 2007..Further, characterization of CIB and its interactions with integrin alphaIIb-beta3 and Plk3 may help in delineating the mechanisms by which cytoplasmic signals modulate integrin function. ..
- Role of JAM Family in AngiogenesisUlhas P Naik; Fiscal Year: 2010..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a mew line of investigation that is important in tumerigenesis and vascular biology. ..
- Adrenomedullin and Human Trophoblast InvasionYuan Lin Dong; Fiscal Year: 2006..Knowledge gained from these studies may assist in designing appropriate therapeutic strategies to prevent preeclampsia in the human. ..
- Fetal Velocimetry & Amino Acid Transport in PregnancyFREDERICK BATTAGLIA; Fiscal Year: 2007..These studies will establish important links between blood flow changes in the fetus and nutrient delivery to the fetus. ..
- Endocytosis in cardiac myocytesIon Jovin; Fiscal Year: 2005..The discoverry of polypeptides that guide macromolecules to specific cellular organelles or compartments can have profound implications for understanding microbial invasion and for refining gene therapy. ..
- Micro-Thickness Collagen Membranes in Tissue EngineeringRobert Vernon; Fiscal Year: 2007..Moreover, data from this work will serve as a foundation for further development of TEBVs. Accordingly, this application is well suited to the purpose of the R21 mechanism. [unreadable] [unreadable] [unreadable]..
- A transmembrane collagen induced in prostate cancerBruce Zetter; Fiscal Year: 2007..Correlation with patient data will enable us to determine whether collagen XXIII has use as a diagnostic or predictive marker in prostate cancer. ..
- Novel High Content Vascular Patterning Assay(RMI)Royce Mohan; Fiscal Year: 2007..We beleve that this HC-HTS platform will offer unique opportunities to screen vast numbers of small molecule inhibitors of angiogenesis and assist in drug discovery. ..
- Ras-PI3K Pathway in Nf1-/-Hematopoiesis and LeukemiaDavid Ingram; Fiscal Year: 2007..abstract_text> ..
- Molecular Target Focused Discovery of Anticancer DrugsGEORGE PETTIT; Fiscal Year: 2007..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
- RICKETTSIA-INDUCED TRANSCRIPTIONAL ACTIVATIONSANJEEV SAHNI; Fiscal Year: 2007..These studies will offer important perspectives in our understanding of rickettsial pathogenesis and may lead to the identification of novel targets for supplemental chemotherapy. ..
- Modulation of Host Cell Apoptosis By Pathogenic RickettsiaeSANJEEV SAHNI; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Targeted enzyme delivery systems for treatment of orphan niemann-pick diseaseSILVIA MURO GALINDO; Fiscal Year: 2007..The clinical benefits of this strategy may be extended to other LSDs. [unreadable] [unreadable] [unreadable] [unreadable]..
- FASL IN PREECLAMPSIA AND IMMUNOTOLERANCE TO THE FETUSScott Kauma; Fiscal Year: 2002..These studies will significantly advance our understanding of the mechanisms involved in the pathogenesis of preeclampsia and provide new rationales for the treatment of this disease. ..
- Selective subplate vulnerability and cortical plasticityPatrick McQuillen; Fiscal Year: 2008..Finally, we hypothesize that treatments that protect sub-plate neurons in vitro will also prevent sub-plate neuron cell death following early hypoxia ischemia. [unreadable] [unreadable]..
- ENDOTHELIAL-DEPENDENT VASODILATATION IN PREECLAMPSIAScott Kauma; Fiscal Year: 2003..The K24 award will protect this candidates time and help him to mature into a senior investigator in OB/GYN. ..
- INITIATION AND REGULATION OF BLOOD COAGULATIONVIJAYA MOHAN RAO LELLA; Fiscal Year: 2010..abstract_text> ..
- EICOSANOIDS AND PULMONARY VASCULAR TONESANDRA PFISTER; Fiscal Year: 2002....
- Molecular Biology of Erythrocyte AnkyrinPatrick G Gallagher; Fiscal Year: 2010..These studies may provide important information to be used for diagnosis and treatment of patients with this disorder. ..
- SHIFTS IN ACTIN-MICROTUBULE FORCES IN THE ENDOTHELIUMALAN MOY; Fiscal Year: 2004..We will utilize molecular approaches and quantitative dynamic imaging approaches in living cells to further validate our hypothesis. We believe that the results of these studies will greatly advance vascular and cell biology. ..
- THE ROLE OF MEN IN FAMILY FORMATION AND PARENTINGRenata Forste; Fiscal Year: 2001..Overall, the primary aim of the study is to heighten understanding of the mechanisms underlying the role of men in nonmarital childbearing, as well as the early involvement of men with their children. ..
- Cord Blood Cells in ALS: Replacement of Protection?Svitlana Garbuzova Davis; Fiscal Year: 2004..The results of this study may provide the basis for developing a novel, non-invasive therapy, easily accessed by ALS patients. ..
- White Matter Injury in Critical Ill Newborns With Congenital Heart DiseasePatrick Sean McQuillen; Fiscal Year: 2010..Page McQuillen, Patrick S. ..
- PREVENTION OF VASCULOPATHY AND NEPHROPATHY IN METABOLIC SYNDROMEMichael S Goligorsky; Fiscal Year: 2010..abstract_text> ..
- Regulatory Oxygenases in Vasculopathic RickettsiosesSANJEEV SAHNI; Fiscal Year: 2010....
- Injury - Induced Endothelial DysfunctionFiemu Nwariaku; Fiscal Year: 2008..The overall objectives are to determine the role of intracellular oxidants, rho and MAPK pathways on junctional phosphorylation and endothelial dysfunction. [unreadable] [unreadable]..
- Genotypic Determinants of Aspirin Response in High Risk FamiliesLewis Becker; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Molecular Target Focused Discovery of Anticancer DrugsGeorge R Pettit; Fiscal Year: 2010....
- Genome-Wide Association of Platelet PhenotypesLewis Becker; Fiscal Year: 2009..This study represents the first genome -wide SNP association study of comprehensive platelet function and should lead to novel tailored anti-platelet therapy for the prevention of vascular thromboses. (End of Abstract) ..
- Receptor Tyrosine Kinases in MechanotransductionZheng Gen Jin; Fiscal Year: 2009..In this pathway, VEGFR2 may emerge as a central mediator for laminar flow atheroprotective effects, which will provide new insight into the prevention of atherosclerotic vascular disease. ..
- PKD Family Kinases and Idiopathic Pulmonary FibrosisHua Tang; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- INTEGRINS IN ACUTE RENAL FAILUREMICHAEL GOLIGORSKY; Fiscal Year: 2002....
- Hematopoietic Precursor Development from Human Embryonic Stem (ES) CellsDan S Kaufman; Fiscal Year: 2010..These cells may also be used as a new source for transfusion medicine. ..
- Single-Molecule Immunoassay and DNA ScreeningEdward Yeung; Fiscal Year: 2005..The first two goals will be the focus of the R21 Phase and the last two goals will be the focus of the R33 Phase of this application. ..
- Purinergic signaling in endothelial cells.Elzbieta Kaczmarek; Fiscal Year: 2005..abstract_text> ..
- Mechanism of anti-phagocytosis by Yersinia pestisKristiina Vuori; Fiscal Year: 2005..We further expect that the inhibitors to be identified will be a valuable starting point for the further development of novel drugs that can be used to combat plague mortality. ..
- In Vivo Potential of Human ES Cell-Derived Blood CellsDAN KAUFMAN; Fiscal Year: 2004..abstract_text> ..
- TARGETED ULTRASOUND IMAGING OF TUMORSPaul Dayton; Fiscal Year: 2004..Finally, the effect of contrast agent localization due to acoustic radiation force will be studied on targeting efficiency. ..
- SIGNAL TRANSDUCTION BY P130CAS AND C CRKKristiina Vuori; Fiscal Year: 2004..Once completed, these studies are expected to yield significant new information on the role of the Cas-Crk signaling complex in intracellular signaling events. ..
- Retrotransposons as site-specific gene delivery vectorsJOHN GOODIER; Fiscal Year: 2003..In addition, I will assay in cell culture the efficiency of the L1 at integrating increasing lengths of exogenous DNA. ..
- SUBPLATE NEURONS AND EARLY HYPOXIC ISCHEMIC BRAIN INJURYPatrick McQuillen; Fiscal Year: 2002....
- Bartonella Inhibitory Factor for Endothelial Cell GrowthMICHAEL MINNICK; Fiscal Year: 2002..abstract_text> ..
- DETERMINANTS OF CORONARY DISEASE IN HIGH RISK FAMILIESLewis Becker; Fiscal Year: 2001..This study will provide important insights into the phenotypic and genetic determinants of clinical and occult CHD in families with premature CHD. ..
- CONFERENCE/WORKSHOP ON EPR SPECTROSCOPY AND IMAGINGPeriannan Kuppusamy; Fiscal Year: 2005..S. members of the International Advisory Committee for this meeting. Particular emphasis will be given to the minority and women scientists, encouraging their active participation. ..
- ENDOTHELIAL DYSFUNCTION: FORMATION OF MICROPARTICLESSergey Brodsky; Fiscal Year: 2005..The proposed studies may provide novel information on the contribution of microparticles to the pathophysiology of endothelial cell dysfunction and coagulation abnormalities. ..
- In Vivo EPR Imaging of Redox Status and Thiols in TumorPeriannan Kuppusamy; Fiscal Year: 2007..The results will enable a better understanding of the development of drug resistance in ovarian cancer and offer efficient diagnosis for effective treatment of ovarian cancer patients. ..
- Endothelial dysfunction in acute renal ischemiaMICHAEL GOLIGORSKY; Fiscal Year: 2007..Number of publicationsand manuscriptsacceptedfor publication (not to exceed 10) 10 Other items (list): 1. Color illustrations from the grant application 2. Movies - intravital videomicroscopy supplement ..
- Junction Adhesion Molecule CAR and the Immune SystemSteven Carson; Fiscal Year: 2007..This work will advance knowledge of cells that form tight _junctions and their interactions with cells and molecules that must cross those barriers. ..
- SIGNAL TRANSDUCTION THOUGH THE C-CBL PROTOONCOGENEKristiina Vuori; Fiscal Year: 2001..In each case, the effects on various biochemical and biological signaling events will be studied. ..
- Biosensor to measure microscopic cell functionALAN MOY; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Coronary Disease Detection by Thalluim SPECT and Fast CTLewis Becker; Fiscal Year: 2006..unreadable] [unreadable]..
- Hemin Receptor Gene Family of Bartonella quintanaMICHAEL MINNICK; Fiscal Year: 2006..abstract_text> ..
- Oral infection and inflammation in transplant patientsAnna Dongari Bagtzoglou; Fiscal Year: 2005....
- Iron and O2 in the Regulation of P. aeruginosa VirulenceMichael Vasil; Fiscal Year: 2003..This project will investigate the role of PA-Fur and PA-Fur regulated genes in the pathogenesis of P. aeruginosa infections for the ultimate goal or developing novel antimicrobial agents against this formidable opportunist. ..
- Novel Class of Phospholipases-Molecular PathogenesisMichael Vasil; Fiscal Year: 2007..Furthermore, it is likely that information we derive from our efforts will also provide additional insights about the biochemistry and biology of PLCs in general. ..
- Fetal and Neonatal Hemodynamics in IUGR PregnanciesHenry Galan; Fiscal Year: 2006..abstract_text> ..