neural crest

Summary

Summary: A strip of specialized ectoderm flanking each side of the embryonal neural plate, which after the closure of the neural tube, forms a column of isolated cells along the dorsal aspect of the neural tube. Most of the cranial and all of the spinal sensory ganglion cells arise by differentiation of neural crest cells.

Top Publications

  1. doi A gene regulatory network orchestrates neural crest formation
    Tatjana Sauka-Spengler
    Division of Biology 13974, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Mol Cell Biol 9:557-68. 2008
  2. ncbi Sox10 overexpression induces neural crest-like cells from all dorsoventral levels of the neural tube but inhibits differentiation
    Sonja J McKeown
    Embryology Laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, and Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
    Dev Dyn 233:430-44. 2005
  3. ncbi Neuropilin 2/semaphorin 3F signaling is essential for cranial neural crest migration and trigeminal ganglion condensation
    Laura S Gammill
    Division of Biology 139 74, California Institute of Technology, Pasadena, California 91125, USA
    Dev Neurobiol 67:47-56. 2007
  4. ncbi Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates
    K A Dutton
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Development 128:4113-25. 2001
  5. ncbi nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate
    J A Lister
    Department of Biological Structure, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
    Development 126:3757-67. 1999
  6. pmc Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
    Alexander D Boiko
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304 5542, USA
    Nature 466:133-7. 2010
  7. pmc Contact inhibition of locomotion in vivo controls neural crest directional migration
    Carlos Carmona-Fontaine
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Nature 456:957-61. 2008
  8. pmc Collective chemotaxis requires contact-dependent cell polarity
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Dev Cell 19:39-53. 2010
  9. ncbi Fate of the mammalian cardiac neural crest
    X Jiang
    Departments of Biological Sciences and Cell and Neurobiology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, IGM 240, Los Angeles, CA 90033, USA
    Development 127:1607-16. 2000
  10. ncbi Tissue origins and interactions in the mammalian skull vault
    Xiaobing Jiang
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Dev Biol 241:106-16. 2002

Detail Information

Publications386 found, 100 shown here

  1. doi A gene regulatory network orchestrates neural crest formation
    Tatjana Sauka-Spengler
    Division of Biology 13974, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Mol Cell Biol 9:557-68. 2008
    The neural crest is a multipotent, migratory cell population that is unique to vertebrate embryos and gives rise to many derivatives, ranging from the peripheral nervous system to the craniofacial skeleton and pigment cells...
  2. ncbi Sox10 overexpression induces neural crest-like cells from all dorsoventral levels of the neural tube but inhibits differentiation
    Sonja J McKeown
    Embryology Laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, and Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
    Dev Dyn 233:430-44. 2005
    SoxE genes (Sox8, Sox9, and Sox10) are early response genes to neural crest induction...
  3. ncbi Neuropilin 2/semaphorin 3F signaling is essential for cranial neural crest migration and trigeminal ganglion condensation
    Laura S Gammill
    Division of Biology 139 74, California Institute of Technology, Pasadena, California 91125, USA
    Dev Neurobiol 67:47-56. 2007
    In the head of vertebrate embryos, neural crest cells migrate from the neural tube into the presumptive facial region and condense to form cranial ganglia and skeletal elements in the branchial arches...
  4. ncbi Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates
    K A Dutton
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Development 128:4113-25. 2001
    ..Using iontophoretic labelling of neural crest cells, we demonstrate that colourless mutant neural crest cells form ectomesenchymal fates...
  5. ncbi nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate
    J A Lister
    Department of Biological Structure, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
    Development 126:3757-67. 1999
    We report the isolation and identification of a new mutation affecting pigment cell fate in the zebrafish neural crest. Homozygous nacre (nac(w2)) mutants lack melanophores throughout development but have increased numbers of iridophores...
  6. pmc Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
    Alexander D Boiko
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304 5542, USA
    Nature 466:133-7. 2010
    ....
  7. pmc Contact inhibition of locomotion in vivo controls neural crest directional migration
    Carlos Carmona-Fontaine
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Nature 456:957-61. 2008
    ..Here we show that neural crest cells, a highly migratory and multipotent embryonic cell population, whose behaviour has been likened to ..
  8. pmc Collective chemotaxis requires contact-dependent cell polarity
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Dev Cell 19:39-53. 2010
    ..However, how a cluster of cells responds to chemoattractants is not fully understood. Neural crest cells are among the most motile cells in the embryo, and their behavior has been likened to malignant invasion...
  9. ncbi Fate of the mammalian cardiac neural crest
    X Jiang
    Departments of Biological Sciences and Cell and Neurobiology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, IGM 240, Los Angeles, CA 90033, USA
    Development 127:1607-16. 2000
    A subpopulation of neural crest termed the cardiac neural crest is required in avian embryos to initiate reorganization of the outflow tract of the developing cardiovascular system...
  10. ncbi Tissue origins and interactions in the mammalian skull vault
    Xiaobing Jiang
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Dev Biol 241:106-16. 2002
    ..Using a transgenic mouse with a permanent neural crest cell lineage marker, Wnt1-Cre/R26R, we show that both sutures are formed at a neural crest-mesoderm interface: ..
  11. pmc Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness
    Genevieve M Kruger
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Neuron 35:657-69. 2002
    We found neural crest stem cells (NCSCs) in the adult gut. Postnatal gut NCSCs were isolated by flow-cytometry and compared to fetal gut NCSCs. They self-renewed extensively in culture but less than fetal gut NCSCs...
  12. pmc Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton
    Courtney Alexander
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 138:5135-46. 2011
    ..With a BMP-responsive transgene, Tg(Bre:GFP), we show active BMP signaling in neural crest (NC)-derived skeletal precursors of the ventral arches, and in surrounding epithelia...
  13. ncbi Control of cell behavior during vertebrate development by Slug, a zinc finger gene
    M A Nieto
    Instituto Cajal, Madrid, Spain
    Science 264:835-9. 1994
    Slug, a vertebrate gene encoding a zinc finger protein of the Snail family, is expressed in the neural crest and in mesodermal cells emigrating from the primitive streak...
  14. pmc DHODH modulates transcriptional elongation in the neural crest and melanoma
    Richard Mark White
    Stem Cell Program and Hematology Oncology, Children s Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:518-22. 2011
    Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, ..
  15. pmc The transcription factor Sox10 is a key regulator of peripheral glial development
    S Britsch
    Max Delbruck Center for Molecular Medicine, D 13122 Berlin, Germany
    Genes Dev 15:66-78. 2001
    ..Peripheral glial cells differentiate from pluripotent neural crest cells...
  16. doi Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad
    Narihito Nagoshi
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 2:392-403. 2008
    Although recent reports have described multipotent, self-renewing, neural crest-derived stem cells (NCSCs), the NCSCs in various adult rodent tissues have not been well characterized or compared...
  17. ncbi Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis
    Fabio Santagati
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104, BP 10142, CU de Strasbourg, 67404 Illkirch Cedex, France
    Development 132:4927-36. 2005
    ..Here, we show that Hoxa2 is selectively required in cranial neural crest cells (NCCs)...
  18. doi Derivation of neural crest cells from human pluripotent stem cells
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Nat Protoc 5:688-701. 2010
    Human pluripotent stem cell (hPSC)-derived neural crest (NC) cells present a valuable tool for modeling aspects of human NC development, including cell fate specification, multipotency and cell migration...
  19. ncbi Zebrafish pigmentation mutations and the processes of neural crest development
    R N Kelsh
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:369-89. 1996
    b>Neural crest development involves cell-fate specification, proliferation, patterned cell migration, survival and differentiation...
  20. ncbi Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, New York 10021, USA
    Nat Biotechnol 25:1468-75. 2007
    Vertebrate neural crest development depends on pluripotent, migratory precursor cells. Although avian and murine neural crest stem (NCS) cells have been identified, the isolation of human NCS cells has remained elusive...
  21. pmc The neural crest in cardiac congenital anomalies
    Anna Keyte
    Department of Pediatrics Neonatology, Neonatal Perinatal Research Institute, Box 103105, Duke University Medical Center, Durham, NC 27710, USA
    Differentiation 84:25-40. 2012
    This review discusses the function of neural crest as they relate to cardiovascular defects...
  22. doi Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, UK
    Dev Biol 366:34-54. 2012
    After induction and specification in the ectoderm, at the border of the neural plate, the neural crest (NC) population leaves its original territory through a delamination process...
  23. pmc Current perspectives of the signaling pathways directing neural crest induction
    Timothy J Stuhlmiller
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Cell Mol Life Sci 69:3715-37. 2012
    The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body...
  24. doi Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/β-catenin signaling
    Shin Hatou
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Stem Cells Dev 22:828-39. 2013
    ..Both corneal endothelial cells and stromal cells originate from the neural crest, but have distinct phenotypes and function in the adult cornea...
  25. pmc MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
    Johann K Eberhart
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Nat Genet 40:290-8. 2008
    ..Mirn140 modulated Pdgf-mediated attraction of cranial neural crest cells to the oral ectoderm, where crest-derived signals were necessary for oral ectodermal gene expression...
  26. pmc Concise review: adult mesenchymal stem cells, adult neural crest stem cells, and therapy of neurological pathologies: a state of play
    Virginie Neirinckx
    University of Liege, Belgium
    Stem Cells Transl Med 2:284-96. 2013
    ..With regard to lately published results, the ability of adult mesenchymal stem cells (MSCs) and neural crest stem cells (NCSCs) to integrate and differentiate into neurons once inside the central nervous system (CNS) is ..
  27. ncbi PlexinA2 and semaphorin signaling during cardiac neural crest development
    C B Brown
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Development 128:3071-80. 2001
    Classic studies using avian model systems have demonstrated that cardiac neural crest cells are required for proper development of the cardiovascular system...
  28. pmc CHD7 cooperates with PBAF to control multipotent neural crest formation
    Ruchi Bajpai
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 463:958-62. 2010
    ..Although it was postulated 25 years ago that CHARGE syndrome results from the abnormal development of the neural crest, this hypothesis remained untested...
  29. ncbi Gene-regulatory interactions in neural crest evolution and development
    Daniel Meulemans
    California Institute of Technology, 1200 East California Boulevard, Pasadena 91125, USA
    Dev Cell 7:291-9. 2004
    In this review, we outline the gene-regulatory interactions driving neural crest development and compare these to a hypothetical network operating in the embryonic ectoderm of the cephalochordate amphioxus...
  30. pmc Craniofacial birth defects: The role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention
    Paul A Trainor
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Am J Med Genet A 152:2984-94. 2010
    ....
  31. ncbi The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites
    P Soriano
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Development 124:2691-700. 1997
    ..Patch mutant mice harbor a deletion including the PDGF alpha receptor gene and exhibit defects of neural crest origin which affect pigmentation in heterozygotes and cranial bones in homozygotes...
  32. ncbi The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
    A Pattyn
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Université de la Méditterranée AP de Marseille, France
    Nature 399:366-70. 1999
    ..ganglia are the main components of the peripheral autonomic nervous system, and are all derived from the neural crest. The factors needed for these structures to develop include the transcription factor Mash1, the glial-derived ..
  33. ncbi Wnt signalling required for expansion of neural crest and CNS progenitors
    M Ikeya
    Centre for Molecular and Developmental Biology, Faculty of Science, Kyoto University, Japan
    Nature 389:966-70. 1997
    ..Here we demonstrate that in the absence of both Wnt- and Wnt-3a there is a marked deficiency in neural crest derivatives, which originate from the dorsal neural tube, and a pronounced reduction in dorsolateral neural ..
  34. pmc Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin
    Christine E Wong
    Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 175:1005-15. 2006
    ..the isolation of multipotent stem cell-like cells from the adult trunk skin of mice and humans that express the neural crest stem cell markers p75 and Sox10 and display extensive self-renewal capacity in sphere cultures...
  35. pmc Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest
    Alvaro Rada-Iglesias
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 11:633-48. 2012
    b>Neural crest cells (NCC) are a transient, embryonic cell population characterized by unusual migratory ability and developmental plasticity...
  36. pmc Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest
    Kevin Curran
    Department of Biology, University of Washington, Seattle, WA 98195 7420, USA
    Dev Biol 344:107-18. 2010
    ..In the zebrafish, neural crest cells generate three types of pigment cells during embryogenesis: yellow xanthophores, iridescent iridophores ..
  37. ncbi Control of neural crest cell fate by the Wnt signalling pathway
    R I Dorsky
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle 98195, USA
    Nature 396:370-3. 1998
    Environmental signals are important in the development of neural crest, during which process multipotent progenitor must choose from several fates. However, the nature of these environmental signals is unknown...
  38. doi Neural crest progenitors and stem cells: from early development to adulthood
    Elisabeth Dupin
    Inserm U894 Equipe Plasticité gliale, Centre de Psychiatrie et de Neuroscience, 2 ter Rue d Alésia 75014 Paris, France
    Dev Biol 366:83-95. 2012
    In the vertebrate embryo, the neural crest forms transiently in the dorsal neural primordium to yield migratory cells that will invade nearly all tissues and later, will differentiate into bones and cartilages, neurons and glia, endocrine ..
  39. pmc What is bad in cancer is good in the embryo: importance of EMT in neural crest development
    Laura Kerosuo
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, United States
    Semin Cell Dev Biol 23:320-32. 2012
    ..A prime example of EMT during development occurs when neural crest (NC) cells emigrate from the neural tube thus providing an excellent model to study the principles of EMT in a ..
  40. ncbi Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
    F Guillemot
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Cell 75:463-76. 1993
    ..These observations suggest that Mash-1, like its Drosophila homologs of the AS-C, controls a basic operation in development of neuronal progenitors in distinct neural lineages...
  41. ncbi MGF (KIT ligand) is a chemokinetic factor for melanoblast migration into hair follicles
    S A Jordan
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom
    Dev Biol 225:424-36. 2000
    Melanoblasts, the precursors of the pigment-producing cells of the skin and hair, are derived from the neural crest and migrate to the skin around 12 days of gestation in the mouse...
  42. pmc The connections between neural crest development and neuroblastoma
    Manrong Jiang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Curr Top Dev Biol 94:77-127. 2011
    ..Therefore, this review focuses on the development of the peripheral trunk neural crest, the current understanding of how developmental factors may contribute to NB and on recent advances in the ..
  43. ncbi twist is required in head mesenchyme for cranial neural tube morphogenesis
    Z F Chen
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:686-99. 1995
    ..These results suggest that twist regulates the cellular phenotype and behavior of head mesenchyme cells that are essential for the subsequent formation of the cranial neural tube...
  44. ncbi The origin and development of glial cells in peripheral nerves
    Kristjan R Jessen
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:671-82. 2005
    During the development of peripheral nerves, neural crest cells generate myelinating and non-myelinating glial cells in a process that parallels gliogenesis from the germinal layers of the CNS...
  45. pmc Identification of a rudimentary neural crest in a non-vertebrate chordate
    Philip Barron Abitua
    Center for Integrative Genomics, Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nature 492:104-7. 2012
    b>Neural crest arises at the neural plate border, expresses a core set of regulatory genes and produces a diverse array of cell types, including ectomesenchyme derivatives that elaborate the vertebrate head...
  46. ncbi Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells
    S J Morrison
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 20:7370-6. 2000
    Isolated neural crest stem cells (NCSCs) differentiate to autonomic neurons in response to bone morphogenetic protein 2 (BMP2) in clonal cultures, but these neurons do not express sympathoadrenal (SA) lineage markers...
  47. pmc Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest
    Igor Adameyko
    Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden
    Development 139:397-410. 2012
    ..Conditional gain- and loss-of-function experiments show genetically that cell fates in the neural crest involve both the SRY transcription factor Sox2 and Mitf, which consolidate an SCP progenitor or melanocyte fate ..
  48. ncbi Reprogramming metastatic tumour cells with embryonic microenvironments
    Mary J C Hendrix
    Cancer Biology and Epigenomics Program, Children s Memorial Research Centre, Robert H Lurie Comprehensive Cancer Centre, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Nat Rev Cancer 7:246-55. 2007
    ..This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration...
  49. pmc Neuropilin receptors guide distinct phases of sensory and motor neuronal segmentation
    Julaine Roffers-Agarwal
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Development 136:1879-88. 2009
    The segmented trunk peripheral nervous system is generated by ventrally migrating neural crest cells that exclusively invade the anterior sclerotome and differentiate into metameric dorsal root and sympathetic ganglia...
  50. ncbi Transforming growth factor-beta-induced differentiation of smooth muscle from a neural crest stem cell line
    Shiyou Chen
    Department of Cell Biology, Georgetown University Medical School, Washington, DC 20057, USA
    Circ Res 94:1195-202. 2004
    ..In vivo, cells derived from the multipotent neural crest can give rise to vascular smooth muscle in parts of the head and also the cardiac outflow tract...
  51. pmc Melanoma spheroids grown under neural crest cell conditions are highly plastic migratory/invasive tumor cells endowed with immunomodulator function
    Kiran Ramgolam
    Unité Mixte de Recherche Scientifique 940, Institut National de la Sante et de la Recherche Medicale, Universite Paris Diderot Paris 7, Hopital St Louis, Paris, France
    PLoS ONE 6:e18784. 2011
    ....
  52. pmc Modeling initiation of Ewing sarcoma in human neural crest cells
    Cornelia von Levetzow
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e19305. 2011
    ..Although the histogenesis of ESFT is controversial, mesenchymal (MSC) and/or neural crest (NCSC) stem cells have been implicated as cells of origin...
  53. ncbi Cell proliferation drives neural crest cell invasion of the intestine
    Matthew J Simpson
    Department of Mathematics and Statistics, University of Melbourne, and The Murdoch Childrens Research Institute, Victoria 3010, Australia
    Dev Biol 302:553-68. 2007
    ..to experimentally validate these predictions is the directional invasion and colonization of the gut by vagal neural crest cells that establish the enteric nervous system...
  54. ncbi Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Development 121:1321-32. 1995
    We identified two cadherins, c-cad6B and c-cad7, expressed by neural crest cells at their premigratory and migratory stages, respectively, in chicken embryos...
  55. ncbi The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration
    Christine B Gurniak
    European Molecular Biology Laboratory, Mouse Biology Programme, Adriano Buzzati Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy
    Dev Biol 278:231-41. 2005
    ..Here we show that in mouse the non-muscle-specific gene-n-cofilin-is essential for migration of neural crest cells as well as other cell types in the paraxial mesoderm...
  56. pmc Molecular analysis of neural crest migration
    Sei Kuriyama
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Philos Trans R Soc Lond B Biol Sci 363:1349-62. 2008
    The neural crest (NC) cells have been called the 'explorers of the embryos' because they migrate all over the embryo where they differentiate into a variety of diverse kinds of cells...
  57. ncbi Neural crest emigration from the neural tube depends on regulated cadherin expression
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Development 125:2963-71. 1998
    During the emergence of neural crest cells from the neural tube, the expression of cadherins dynamically changes...
  58. ncbi Recent advances in craniofacial morphogenesis
    Yang Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    Dev Dyn 235:2353-75. 2006
    ..in our understanding of evo-devo as it relates to craniofacial morphogenesis, fate determination of cranial neural crest cells, and specific signaling pathways in regulating tissue-tissue interactions during patterning of ..
  59. ncbi DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets
    Martin S Staege
    Children s Cancer Research Center, Division of Pediatric Hematology and Oncology and BioCenter, Martin Luther University Halle Wittenberg, Halle, Germany
    Cancer Res 64:8213-21. 2004
    ..between EFTs and fetal and neuronal as well as endothelial tissues and supports the concept that a primitive neural crest-derived progenitor at the transition to mesenchymal and endothelial differentiation is transformed in EFTs...
  60. ncbi Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
    Yoshihiro Ito
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Development 130:5269-80. 2003
    ..understood, however, what the functional significance of TGFbeta signaling is in regulating the fate of cranial neural crest (CNC) cells during craniofacial development...
  61. pmc Neural crest origins of the neck and shoulder
    Toshiyuki Matsuoka
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Nature 436:347-55. 2005
    ..To identify its underlying mechanisms we map the destinations of embryonic neural crest and mesodermal stem cells using Cre-recombinase-mediated transgenesis...
  62. ncbi Neuroepithelial cells supply an initial transient wave of MSC differentiation
    Yasuhiro Takashima
    Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
    Cell 129:1377-88. 2007
    ..mediated lineage tracing, we provide evidence that Sox1+ neuroepithelium gives rise to MSCs in part through a neural crest intermediate stage...
  63. ncbi Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies
    Tiffany A Heanue
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Rev Neurosci 8:466-79. 2007
    ..been unravelling the molecular mechanisms underlying the migration, proliferation and differentiation of the neural crest derivatives that give rise to the ENS, human geneticists have been uncovering the genetic basis for diseases of ..
  64. ncbi Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    V Brault
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:1253-64. 2001
    ..phenotype, not observed in embryos that lack Wnt1, indicates a role for beta-catenin in the fate of neural crest cells...
  65. pmc Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects
    Zhan Peng Huang
    Department of Cell and Developmental Biology, McAllister Heart Institute, School of Medicine, University of North Carolina, Chapel Hill, USA
    Arterioscler Thromb Vasc Biol 30:2575-86. 2010
    ..Disturbance of neural crest cell (NCC) migration into the derivatives of the pharyngeal arches and pouches can account for many of the ..
  66. doi Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system
    Chihiro Nishiyama
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan
    Nat Neurosci 15:1211-8. 2012
    Cell migration is fundamental to organogenesis. During development, the enteric neural crest cells (ENCCs) that give rise to the enteric nervous system (ENS) migrate and colonize the entire length of the gut, which undergoes substantial ..
  67. doi How to make a heart: the origin and regulation of cardiac progenitor cells
    Stephane D Vincent
    Institut Pasteur, Departement de Biologie du Developpement, CNRS URA 2578, Paris, France
    Curr Top Dev Biol 90:1-41. 2010
    ..mesoderm of the first and second heart field (SHF), with an additional contribution of neurectodermally derived neural crest cells that are critical for the maturation of the arterial pole of the heart...
  68. pmc Postnatal intestinal engraftment of prospectively selected enteric neural crest stem cells in a rat model of Hirschsprung disease
    Y H Tsai
    Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA
    Neurogastroenterol Motil 23:362-9. 2011
    ..We investigated the ability of unselected gut cells vs selected enteric neural crest stem cells (eNCSCs) to engraft and differentiate in the postnatal gut in the Hirschsprung disease (HD, ednrb(sl/..
  69. pmc Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury
    Cátia Laranjeira
    Division of Molecular Neurobiology, Medical Research Council National Institute for Medical Research, London, United Kingdom
    J Clin Invest 121:3412-24. 2011
    The enteric nervous system (ENS) in mammals forms from neural crest cells during embryogenesis and early postnatal life...
  70. doi Antagonistic activities of Rho and Rac GTPases underlie the transition from neural crest delamination to migration
    Irit Shoval
    Department of Medical Neurobiology, Hebrew University Hadassah Medical School, IMRIC and ELSC, Jerusalem, Israel
    Dev Dyn 241:1155-68. 2012
    b>Neural crest progenitors arise as epithelial cells and then undergo a transition into mesenchyme that generates motility...
  71. ncbi The pattern of neural crest advance in the cecum and colon
    Noah R Druckenbrod
    Department of Anatomy, and Neuroscience Training Program, University of Wisconsin Medical School, Madison, WI 53706, USA
    Dev Biol 287:125-33. 2005
    b>Neural crest cells leave the hindbrain, enter the gut mesenchyme at the pharynx, and migrate as strands of cells to the terminal bowel to form the enteric nervous system...
  72. ncbi Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha
    Veerle Compernolle
    Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Res 60:569-79. 2003
    ..We attempted to further characterize the underlying mechanisms resulting in abnormal cardiogenesis and defective angiogenesis in mice deficient for HIF-1alpha (HIF-1alpha(-/-))...
  73. pmc Prospective identification and isolation of enteric nervous system progenitors using Sox2
    Tiffany A Heanue
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Stem Cells 29:128-40. 2011
    ..ENS, is characterized by absence of enteric ganglia from the distal gut due to defects in gut colonization by neural crest progenitor cells and is an excellent candidate for future cell replacement therapies...
  74. ncbi SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells
    Jaesang Kim
    Howard Hughes Medical Institute, Division of Biology 216 76, California Institute of Technology, Pasadena, California 91125, USA
    Neuron 38:17-31. 2003
    The mechanisms that establish and maintain the multipotency of stem cells are poorly understood. In neural crest stem cells (NCSCs), the HMG-box factor SOX10 preserves not only glial, but surprisingly, also neuronal potential from ..
  75. pmc The origin and evolution of the neural crest
    Philip C J Donoghue
    Department of Earth Sciences, University of Bristol, UK
    Bioessays 30:530-41. 2008
    Many of the features that distinguish the vertebrates from other chordates are derived from the neural crest, and it has long been argued that the emergence of this multipotent embryonic population was a key innovation underpinning ..
  76. pmc Cranial neural crest cells on the move: their roles in craniofacial development
    Dwight R Cordero
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet A 155:270-9. 2011
    ..the majority of skeletal and connective tissues in the face is a pluripotent population of cells, the cranial neural crest cells (NCCs)...
  77. pmc Assembling neural crest regulatory circuits into a gene regulatory network
    Paola Betancur
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Annu Rev Cell Dev Biol 26:581-603. 2010
    The neural crest is a multipotent stem cell–like population that gives rise to a wide range of derivatives in the vertebrate embryo including elements of the craniofacial skeleton and peripheral nervous system as well as ..
  78. pmc Wnt signaling and a Smad pathway blockade direct the differentiation of human pluripotent stem cells to multipotent neural crest cells
    Laura Menendez
    Department of Biochemistry and Molecular Biology, Paul D Coverdell Center for Biomedical and Health Sciences, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 108:19240-5. 2011
    b>Neural crest stem cells can be isolated from differentiated cultures of human pluripotent stem cells, but the process is inefficient and requires cell sorting to obtain a highly enriched population...
  79. ncbi Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice
    A Mansouri
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Development 122:831-8. 1996
    ..Pax7 is a member of the paired box containing gene family. Its expression pattern suggests a function in cephalic neural crest derivatives, skeletal muscle and central nervous system development...
  80. doi Cell lineage in mammalian craniofacial mesenchyme
    Toshiyuki Yoshida
    Department of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Mech Dev 125:797-808. 2008
    We have analysed the contributions of neural crest and mesoderm to mammalian craniofacial mesenchyme and its derivatives by cell lineage tracing experiments in mouse embryos, using the permanent genetic markers Wnt1-cre for neural crest ..
  81. pmc Development and evolution of the neural crest: an overview
    Marianne E Bronner
    California Institute of Technology MC 139 74 Pasadena, CA 91125, USA
    Dev Biol 366:2-9. 2012
    The neural crest is a multipotent and migratory cell type that forms transiently in the developing vertebrate embryo...
  82. pmc Transcription factor Sox10 orchestrates activity of a neural crest-specific enhancer in the vicinity of its gene
    Mandy Wahlbuhl
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Nucleic Acids Res 40:88-101. 2012
    The Sox10 transcription factor is a central regulator of vertebrate neural crest and nervous system development. Its expression is likely controlled by multiple enhancer elements, among them U3 (alternatively known as MCS4)...
  83. ncbi Induction of the neural crest and the opportunities of life on the edge
    Xiao Huang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 275:1-11. 2004
    The neural crest is a multipotent population of migratory cells unique to the vertebrate embryo...
  84. pmc Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells
    Paolo Emanuele Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:6915-27. 2011
    ..Genetic Cre-lox lineage tracing of the neural crest (NC) versus ectodermal contribution to the developing nasal placode was performed using two complementary mouse ..
  85. pmc A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration
    Santanu Banerjee
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Development 138:3287-96. 2011
    Trunk neural crest cells delaminate from the dorsal neural tube as an uninterrupted sheet; however, they convert into segmentally organized streams before migrating through the somitic territory...
  86. pmc Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves
    Rajan Jain
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:422-30. 2011
    ..Using mice with primary and secondary cardiac neural crest deficiencies, we have shown that neural crest contribution to the outflow endocardial cushions (the precursors ..
  87. ncbi Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements
    Steven M Sperber
    Department of Cellular and Molecular Medicine, University of Ottawa, and Ottawa Health Research Institute, Canada
    Dev Biol 314:59-70. 2008
    ..In zebrafish, dlx2a is expressed in the migrating cranial neural crest that contributes to the pharyngeal arches...
  88. pmc Early development of the central and peripheral nervous systems is coordinated by Wnt and BMP signals
    Cedric Patthey
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    PLoS ONE 3:e1625. 2008
    ..Neural plate, neural crest and rostral placodal cells are all specified at the late gastrula stage...
  89. ncbi Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells
    Marek Dudas
    Developmental Biology Program, Departments of Pathology and Surgery, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Mech Dev 121:173-82. 2004
    b>Neural crest cells (NCCs) are pluripotent migratory cells that contribute to the development of various craniofacial structures...
  90. doi Development of mesenchymal stem cells partially originate from the neural crest
    Satoru Morikawa
    Department of Physiology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 379:1114-9. 2009
    ..Here, we prospectively identified MSCs in the bone marrow from adult transgenic mice encoding neural crest-specific P0-Cre/Floxed-EGFP and Wnt1-Cre/Floxed-EGFP...
  91. ncbi Ets-1 expression is associated with cranial neural crest migration and vasculogenesis in the chick embryo
    Siroun A Tahtakran
    Department of Cell and Neurobiology, University of Southern California, Keck School of Medicine, 1333 San Pablo Street, BMT 401, Los Angeles, CA 90089, USA
    Gene Expr Patterns 3:455-8. 2003
    ..To determine whether its expression in the neural crest is consistent with such a function, we have performed a detailed analysis of its expression during early chick ..
  92. ncbi Wnt-frizzled signaling in neural crest formation
    Jinling Wu
    Cell and Molecular Biology Graduate Group, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Trends Neurosci 26:40-5. 2003
  93. ncbi Integration between the epibranchial placodes and the hindbrain
    J Begbie
    Medical Research Council (MRC) Centre for Developmental Neurobiology, Fourth Floor, New Hunts House, Guys Campus, Kings College London, London SE1 9RT, UK
    Science 294:595-8. 2001
    ..This work defines a role for the neuroglial hindbrain crest in organizing the afferent innervation of the hindbrain...
  94. ncbi Posteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction
    Sandra Villanueva
    Millennium Nucleus in Developmental Biology, Facultad de Sciencias, Universidad de Chile, Santiago, Chile
    Dev Biol 241:289-301. 2002
    The neural crest is a unique cell population induced at the lateral border of the neural plate. Neural crest is not produced at the anterior border of the neural plate, which is fated to become forebrain...
  95. ncbi Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity
    Suzanne Bixby
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Neuron 35:643-56. 2002
    ..At embryonic day (E)14, neural crest stem cells (NCSCs) undergo primarily neurogenesis in the gut but gliogenesis in nerves...
  96. pmc Endothelin 3 induces the reversion of melanocytes to glia through a neural crest-derived glial-melanocytic progenitor
    E Dupin
    Institut d Embryologie Cellulaire et Moleculaire, Centre National de la Recherche Scientifique FRE 2160, 49 bis Avenue Belle Gabrielle, 94736 Nogent sur Marne Cedex, France
    Proc Natl Acad Sci U S A 97:7882-7. 2000
    ..signaling of endothelin 3 (ET3) and its receptor B (ETRB) has been shown to be required for the development of neural crest (NC)-derived pigment cells in mouse, but the precise role of ET3 is not completely understood...
  97. ncbi Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3
    Rita C Milewski
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Development 131:829-37. 2004
    Pax3 is a transcription factor that is required by pre-migratory neural crest cells, which give rise to the peripheral nervous system, melanocytes, some vascular smooth muscle, and numerous other derivatives [corrected]...
  98. pmc Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis
    Flavio Cimadamore
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 8:538-51. 2011
    ..model in which migratory cells undergo epithelial to mesenchymal transition (EMT) to acquire properties of neural crest (NC) cells...
  99. ncbi Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice
    K Hosoda
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, Dallas 75235 9050
    Cell 79:1267-76. 1994
    ..These findings indicate an essential role for EDNRB in the development of two neural crest-derived cell lineages, myenteric ganglion neurons and epidermal melanocytes...
  100. ncbi The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain
    H C Etchevers
    Institut d Embryologie Cellulaire et Moleculaire du CNRS et du College de France, 94736 Nogent sur Marne Cedex, France
    Development 128:1059-68. 2001
    Most connective tissues in the head develop from neural crest cells (NCCs), an embryonic cell population present only in vertebrates...
  101. ncbi Cranial neural crest and development of the head skeleton
    Robert D Knight
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Sciences, University of Sheffield, South Yorkshire, UK
    Adv Exp Med Biol 589:120-33. 2006
    The skeletal derivatives of the cranial neural crest (CNC) are patterned through a combination of intrinsic differences between crest cells and extrinsic signals from adjacent tissues, including endoderm and ectoderm...

Research Grants71

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..Both the GDNF receptor, Ret, and the EDN3 receptor Endothelin receptor B (EDNRB) are expressed by the neural crest stem cells (NCSCs) that give rise to the ENS ADDIN EN.CITE ADDIN EN.CITE.DATA [3] ...
  2. A Cis-regulatory Model for Neural Border Induction
    Daniel Meulemans Medeiros; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The neural crest is a population of multipotent progenitor cells that forms at the border of the developing central nervous system and epidermis...
  3. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2012
    ..In vertebrate embryos, for example, neural crest cells leave the developing central nervous system and migrate over long distances to give rise to such cell ..
  4. Ribosomal Protein Gene Silencing in Neural Crest Stem Cells
    JOHNSON MING YU LIU; Fiscal Year: 2010
    ..Our goal is to use mouse embryonic stem (ES) cells heterozygous for Rpl5 or Rpl11 to create neural crest cell models of DBA...
  5. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
    ..palate by generating a conditional allele to perform tissue-specific disruption of EphB4 function in the neural crest-derived mesenchyme...
  6. Ibuprofen and enteric neural crest precursor migration
    ELLEN MERRICK; Fiscal Year: 2013
    ..Hirschsprung Disease (HSCR) is a birth defect of the enteric nervous system that occurs when enteric neural crest-derived cells (ENCCs) do not migrate all the way to the end of the bowel...
  7. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2013
    ..palate by generating a conditional allele to perform tissue-specific disruption of EphB4 function in the neural crest-derived mesenchyme...
  8. Differentiation of Cord Blood Mesenchymal Stem Cells to Corneal Endothelium
    Nancy C Joyce; Fiscal Year: 2010
    ..Since HCEC differentiate from neural crest-derived mesenchymal cells during ocular development, it is reasonable to hypothesize that human umbilical cord ..
  9. FIBROBLAST DIFFERENTIATION DURING EYE DEVELOPMENT
    Gary W Conrad; Fiscal Year: 2012
    ..3) Characterize gene expression in trigeminal neural crest-derived nerves and in their non-myelinating Schwann cells following neuronal growth cone contact with keratan ..
  10. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2013
    ..In vertebrate embryos, for example, neural crest cells leave the developing central nervous system and migrate over long distances to give rise to such cell ..
  11. Plexin signalling in melanocyte biology and melanoma progression
    Glynis A Scott; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human melanocytes are neural crest derived cells that perform a unique function in the skin...
  12. Embryonic Gene Expression During Diabetic Embryopathy
    Mary R Loeken; Fiscal Year: 2013
    ..In particular, expression of Pax3, which is required for neural tube and neural crest development, is significantly reduced in embryos of diabetic mice, and antioxidants block the inhibition of ..
  13. Gene Networks in Neural Crest-derived Innervation of the Lower Urinary Tract
    E MICHELLE MICHELLE SOUTHARD SMITH; Fiscal Year: 2010
    ..The association between neural tube defects and bladder dysfunction as well as the neural crest (NC) origin of sympathetic and parasympathetic inputs that innervate the bladder indicates that NC derivatives ..
  14. Function and regulation of Lhx genes in craniofacial development
    Juhee Jeong; Fiscal Year: 2010
    ..I will verify their activity in chick neural crest electroporation system and transgenic mice...
  15. Role of Cofilin and Wnt Signaling in Neural Crest Development
    O apos NEIL WIGGAN; Fiscal Year: 2013
    ..in mice results in several neural developmental anomalies such as impaired neural tube closure and defective neural crest migration. Similar abnormalities are associated with human congenital diseases...
  16. Effect of Smoking on Adult Stem Cell Differentiation
    Herman S Cheung; Fiscal Year: 2013
    ..Pluripotent stem cells reside in adult human tissues derived from neural crest (NC) and may participate in tissue regeneration or repair...
  17. Mechanisms of FGFR2 Signaling in Craniofacial Development
    Veraragavan P Eswarakumar; Fiscal Year: 2013
    ..Our preliminary data show that mutations in FGFR2 preferentially affect cranial and facial bones of neural crest origin...
  18. The Molecular Genetics of Early Neurogenesis
    Ethan Bier; Fiscal Year: 2013
    ..to treat dorsal spinal chord injuries one may wish to direct differentiating stem cells to assume sensory or neural crest fates under the control of local inductive signals such as Bone morphogenetic proteins (BMPs)...
  19. Genetic Regulation of Rhombomere Formation
    CHARLES G SAGERSTROM; Fiscal Year: 2013
    ..The embryonic hindbrain (and associated neural crest cells) gives rise to many essential structures - sensory ganglia and branchiomotor neurons of the nervous ..
  20. Mechanisms of Neural Crest Differentiation during Craniofacial Development
    Vivian M Lee; Fiscal Year: 2010
    ..cell types in the craniofacial skeleton of vertebrates arises from a migratory stem cell population called the neural crest. Shortly after neural crest cells are formed in the neural tube, they migrate extensively and form diverse ..
  21. Genetic Susceptibility Factors in the Etiology of Neuroblastoma
    Andrew Olshan; Fiscal Year: 2012
    DESCRIPTION: Neuroblastoma (NB) is a tumor of the peripheral nervous system. It is a neural crest cell derivative, originating from the sympathoadreanal lineage, and its development is related to that of normal sympathetic neurons...
  22. Sox10 Alleles for Functional Analysis of Glial Lineages
    E Michelle Southard-Smith; Fiscal Year: 2013
    ..for development of multiple glial lineages including oligodendrocytes in the central nervous system as well as neural crest- derived Schwann cells, satellite glia and enteric nervous system neurons and glia in the periphery...
  23. Smooth Muscle Differentiation and Maturation
    Shiyou Chen; Fiscal Year: 2013
    ..gene to complement 32 (RGC-32), a novel TGF-2 downstream target, is essential for SMC differentiation from neural crest progenitor cells...
  24. Integrated imaging of the form and function of the beating embryonic heart
    ANDREW MARTIN ROLLINS; Fiscal Year: 2013
    ..These new tools may be applied to numerous experimental models such as ablation (e.g. neural crest cells, NCCs), environmental perturbation (e.g. hypoxia), or chemical exposure (e.g. alcohol)...
  25. Risk Factors for Craniosynostosis
    Suzan L Carmichael; Fiscal Year: 2010
    ..intake of nutrients involved in methylation, glycemic control and oxidative stress because folate-responsive neural crest cells contribute to the development of the skull and because glycemic control and hypoxia may contribute to CS...
  26. The Role of Ets1 in Melanocyte Development
    Lidia Kos; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Melanocytes are derived from pluripotent neural crest (NC) cells, which arise from the dorsal aspect of the neural tube...
  27. Receptor Tyrosine Kinase Sorting and Transactivation in Endosomes
    MARK LINDSAY GRIMES; Fiscal Year: 2010
    ..This process is particularly complicated in migrating cells such neurons and neural crest cells, and may go awry, resulting in increased cell proliferation or migration in cancer...
  28. Establishment of Marmoset iPS-derived Cranial Neural Crest Cells
    Steven Farnsworth; Fiscal Year: 2013
    ..For regenerative dentistry goals, deriving cranial neural crest (CNC) cells from iPS cells is an important step for future development of iPS-derived cranial-facial structure ..
  29. Analysis of the Role of Sprouty Genes in Tooth Development
    Ophir Klein; Fiscal Year: 2009
    ..Mammalian tooth development is controlled by signaling between the oral epithelium and the neural crest-derived ectomesenchyme...
  30. Role of the Bradykinin Pathway in Craniofacial Development
    LAURA ANNE JACOX; Fiscal Year: 2013
    ..Specific focus is on the jaws, derived from the neural crest, and on the mouth...
  31. Human iPS/ES Cell-Based Models for Predictive Neural Toxicity and Teratogenicity
    JAMES ALEXANDER THOMSON; Fiscal Year: 2013
    ..yolk sac myeloid progenitors (microglia), migratory mesodermal angioblasts (endothelial cells), and neural crest (vascular smooth muscle and pericytes)...
  32. Role of endocytosis by the neural crest in cardio-craniofacial development
    ANNA LUISE KEYTE; Fiscal Year: 2013
    ..a cardiocraniofacial field, but also that the normal development of these structures depends heavily on the neural crest cells (NCCs). The NCCs are a transient, migratory cell population that gives rise to diverse cell types...
  33. Effects of Hypoxia on Craniofacial Morphology and Molecular Signaling
    FRANCIS JOEL SMITH; Fiscal Year: 2011
    ..Hypoxia disrupted cell proliferation. In early stages of development, apoptosis of neural crest progenitor cells was observed in varying degrees...
  34. Development of the renin-expressing cell
    Maria L Sequeira Lopez; Fiscal Year: 2010
    ..To define whether renin-expressing cells derive from neuroectodermal or neural crest cells we will use available mouse models that mark cells derived from the neuroectoderm, the neural crest and ..
  35. Pax genes in cardiac development
    ZACHARY PAUL NEEB; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Paired box 3 (Pax3) is a transcription factor that is vital for cardiac neural crest (NC) specification and morphogenesis...
  36. Regulation and Role of miR-183-96-182 in Melanocyte Differentiation and Melanoma
    Eva Hernando; Fiscal Year: 2013
    ..express developmental genes, have multi-differentiation potential, and seem to evoke the migratory nature of neural crest stem cells from which melanocytes arise...
  37. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    Sean J Morrison; Fiscal Year: 2013
    The neural crest is a heterogeneous collection of progenitors that migrates out of the dorsal neural tube in early to mid-gestation, depending on the species...
  38. Characterization of neural crest stem cells in human hair follicles.
    Xiaowei Xu; Fiscal Year: 2013
    ..is to investigate the molecular mechanisms that control the proliferation and differentiation of human neural crest stem cells (hNCSCs) and use these cells for regenerative medicine...
  39. Gene Regulation of Cranial Sensory Placode Development
    SALLY ANN MOODY; Fiscal Year: 2013
    ..In addition, migrating cranial neural crest require an interaction with placodes in order to form craniofacial cartilages properly...
  40. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael D Gershon; Fiscal Year: 2013
    ..about genes and molecules that act early in development to regulate colonization of the bowel by enteric neural crest-derived cells (ENCDC) and neurogenesis...
  41. Regulation of Eye Growth and Development by the Lens
    William R Jeffery; Fiscal Year: 2012
    ..life or death of the retina, and the role of the lens in the differentiation and patterning of migratory neural crest cells responsible for cornea and sclera development...
  42. Mesenchymal Regulation of Jaw Bone Length
    Erin L Ealba; Fiscal Year: 2013
    ..The objective of the current study is to build toward this goal by understanding how neural crest mesenchyme (NCM), which forms all the elements in the facial and jaw skeletons, regulates jaw size...
  43. DEFECTIVE FOREBRAIN DEVELOPMENT IN MUTANT MICE
    SAMUEL JEREMY PLEASURE; Fiscal Year: 2013
    ..The cortical meninges are formed by a migration of cranial neural crest cells to cover the cortex at about E10...
  44. Treatment of Osteoradionecrosis with Bone Marrow Stromal Cells
    Sunday O Akintoye; Fiscal Year: 2010
    ..They may be related to the different embryological origins of the craniofacial (neural crest origin) and axial (mesodermal origin) bones, but anatomic skeletal site-specific properties of human BMSC have ..
  45. The Roles of Fat3 and Atrophin-2 in Jaw-Joint Development in Zebrafish
    Pierre Le Pabic; Fiscal Year: 2013
    ..Most of the vertebrate head skeleton derives from migratory neural crest (NC) cells in the embryo...
  46. Taste organs: formation and regulation
    Hongxiang Liu; Fiscal Year: 2013
    ..Our preliminary data on neural crest (NC) derived cell distributions in lingual epithelium, and of phenotypic alterations of tongue and taste ..
  47. NFkB Targets and Neural Crest Development
    MICHAEL WILLIAM KLYMKOWSKY; Fiscal Year: 2010
    The neural crest is a vertebrate innovation, sometimes referred to as the fourth germ layer;the neural crest gives rise to migrating cells that differentiate into cartilage, melanocytes, the peripheral nervous system, and the outflow ..
  48. polr1c and polr1d mutant zebrafish as new models for Treacher Collins syndrome
    KRISTIN EMILY NOACK WATT; Fiscal Year: 2013
    ..of TCS through disrupting the development of a migratory stem and progenitor cell population called neural crest (NC) cells1. Recently, mutations in two new genes POLR1Cand POLR1D were also identified in patients with TCS2...
  49. THE ROLE OF AP-2 IN CRANIOFACIAL DEVELOPMENT
    Trevor J Williams; Fiscal Year: 2013
    ..The Tcfap2a null embryos display multiple defects including orofacial clefting and hypoplasia of the neural crest derived facial skeleton and this is mainly due to loss of AP-2a function in the surface ectoderm...
  50. Fibulin-1 Regulation of the DiGeorge Syndrome Pathogenesis Pathway
    WILLIAM SCOTT ARGRAVES; Fiscal Year: 2012
    ..to determine the role of the extracellular matrix protein, fibulin-1, in regulating the behaviors of cells (neural crest cells) that contribute to the formation of tissues affected in DGS...
  51. Targeting RET in Lung Cancer
    Pasi A Janne; Fiscal Year: 2013
    ..RET is transmembrane receptor tyrosine kinase that is normally expressed in cells derived from neural crest and the urogenital tract...
  52. Proteolysis of cadherins in cranial neural crest
    ANDREW THOMAS SCHIFFMACHER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Craniofacial defects can occur as a result of abnormalities in neural crest (NCC) specification, migration and differentiation...
  53. NEUROFIBROMIN, NEURAL CREST AND CARDIAC DEVELOPMENT
    Jonathan A Epstein; Fiscal Year: 2012
    ....
  54. The Lymphangioleiomyomatosis (LAM)Genome Atlas
    DAVID J contact KWIATKOWSKI; Fiscal Year: 2010
    ..similar, expressing multiple melanocytic proteins, leading to the hypothesis that they are derived from a neural crest progenitor cell...
  55. Intracellular trafficking of Bisphosphonates in bone mesenchymal Stem Cells
    Sunday O Akintoye; Fiscal Year: 2013
    ..We have shown that orofacial bone marrow stromal cells or bone mesenchymal stem cells (BMSCs) from neural crest-derived maxilla/mandible (OFMSCs) are highly proliferative with long population doublings relative to those of ..
  56. Genetic Complexity and Modifiers of Hirschsprung Disease
    E Michelle Southard-Smith; Fiscal Year: 2011
    ..Four of the known HSCR susceptibility loci are up-regulated in neural crest stem cells (NCSC) indicating that HSCR is a consequence of defects in NCSC function...
  57. Shaping the craniofacial skeleton in the zebrafish
    APRIL F DELAURIER; Fiscal Year: 2010
    ..in endochondral bone formation (Aim 1), I will study embryos on the mCherry;fli1:EGFP reporter line which marks neural crest cells. Chondrocytes will be distinguished on the basis of morphology...
  58. Enteric nervous system deficits in Hirschsprung ganglionic bowel
    MELISSA MUSSER; Fiscal Year: 2013
    ..defined by aganglionosis of the distal gastrointestinal tract and is in part due to the abnormal migration of neural crest (NC) derived progenitors of the enteric nervous system...
  59. Nicotinic acetylcholine receptors and neuroblastoma
    Rae Nishi; Fiscal Year: 2012
    ..Furthermore, CHRNA5 is 2-10-fold higher in TICs than in normal neurogenic neural crest stem cells, and CHRNA5 is elevated in primary neuroblastoma tumors and cell lines derived from tumors (SH-SY5Y, ..
  60. Regulators of Melanocyte and Melanoma Cell Identity
    CHARLES KORE KAUFMAN; Fiscal Year: 2013
    ..provided by applicant): Melanocytes are pigment-producing cells in the skin that arise from multipotent neural crest cells...
  61. Myocardin Related Transcription Factor Function in the Vasculature
    Michael S Parmacek; Fiscal Year: 2013
    ..myocardin, MRTF-A and MRTF-B are expressed in distinct developmentally-regulated patterns in mesodermally- and neural crest-derived SMCs, ii) forced expression of myocardin, MRTF-A or MRTF-B in embryonic stem (ES) cells activates ..
  62. SEARCH FOR THE MOLECULAR CAUSES OF DIABETIC EMBRYOPATHY
    Mary R Loeken; Fiscal Year: 2013
    ..expression of Pax3, a gene that encodes a transcription factor required for development of neuroepithelium and neural crest. Reduced expression of Pax3 is associated with increased neural tube and cardiac outflow tract defects, two of ..
  63. STEM CELL FACTOR ACTION IN NEURAL CREST DEVELOPMENT
    Maya Sieber Blum; Fiscal Year: 2003
    ..The long-term goal of the proposed work is to elucidate the cellular and molecular mechanisms that control neural crest cell diversification and differentiation...
  64. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2002
    DESCRIPTION: (Adapted from the investigator's abstract) Neural crest stem cells differentiate into multiple tissues, including the peripheral and enteric nervous systems, the adrenal medulla, and melanocytes...
  65. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2003
    DESCRIPTION: (Adapted from the investigator's abstract) Neural crest stem cells differentiate into multiple tissues, including the peripheral and enteric nervous systems, the adrenal medulla, and melanocytes...
  66. DEVELOPMENT OF NEURONS IN GUT--GROWTH FACTORS
    MILES EPSTEIN; Fiscal Year: 2001
    ..The intrinsic or enteric neurons develop from neural crest cells that migrate from the neural tube and enter the gut...
  67. MOLECULAR BASIS FOR HYPOPLASTIC HEART SYNDROMES
    Eric Olson; Fiscal Year: 2003
    ..steps in cardiac development, particularly in the formation and function of the ventricular chambers and in the neural crest-derived components of the heart...
  68. Genetic Hierarchies and Cellular Behaviors during Zebrafish Palatogenesis
    Johann K Eberhart; Fiscal Year: 2010
    ..Additionally, the simplified palatal skeleton, consisting of far fewer neural crest palate progenitors than in mammals, and the optic clarity of the zebrafish embryo makes it ideal for analyzing ..
  69. Neural Crest Contributions to the Bladder
    E MICHELLE MICHELLE SOUTHARD SMITH; Fiscal Year: 2010
    ..The association between neural tube defects and bladder dysfunction as well as the neural crest (NC) origin of sympathetic and parasympathetic inputs that innervate the bladder implies that NC derivatives ..
  70. TGFb and Cardiac Neural Crest Cell Fate and Function
    Henry Sucov; Fiscal Year: 2009
    ..We have undertaken neural crest-specific disruption of the type II TGFb receptor gene (Tgfbr2) in mice, to address the role of TGFb signaling ..
  71. The Role of PINCH-1 in Regulating Cardiac Neural Crest Behavior
    Jamie Lohr; Fiscal Year: 2007
    ..The normal formation of these structures is dependent on the presence and migration of cardiac neural crest (CMC) cells during development...